LOCUS       NZ_BMVR01000003        23730 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000003
VERSION     NZ_BMVR01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 754944)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 731214
            Orig. end                         :: 754944
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23730
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="6"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..23730
                     /SMILES="C(CC)C(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23730
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[20000:>23730](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..>23730
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     misc_feature    complement(575..591)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            745..1869
                     /locus_tag="IE274_RS10335"
                     /old_locus_tag="GCM10010349_20990"
     CDS             745..1869
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991032.1"
                     /locus_tag="IE274_RS10335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_20990"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_229909418.1"
                     /transl_table=11
                     /translation="MTAIHPAVERADALIDLERYDEAGALLAQRIAEDPADVRAWAKLS
                     RCHLDAGRPDEALAAADEALELDPQDVGGLLMRSYALRRVGGARMPEVETVLREVVRLA
                     PEYWLGHALLADVVFITNVVSRGQANGGQVTPQDMDVSARLAEAHVKEALRLGPEEVYG
                     HEVAYKIASLAGNETVADQLDLAILRLDPHHPQALERQTRKAADTPGVKAVEAADLYAA
                     GLAAAPDSEELRRGLDHATYRMLRGVRWLALLCLGLGASMIDLFAVDGETQRELPVELG
                     QRLWCLVPMSAIWAVGALLRYRRRRTGVQLNVQSLLRRGRWARIVVAQAAWAMLCTLVI
                     TQVPWTDRAVPMVVFWAGLAPTFATVWFDRRKTG"
     gene            1949..>2086
                     /locus_tag="IE274_RS40350"
                     /pseudo=""
     CDS             1949..>2086
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.5"
                     /locus_tag="IE274_RS40350"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSEFEAIDALLAAAPDANPLPPAERRRLLRDELGRSRAQVARALG
                     V"
     gene            2577..3581
                     /locus_tag="IE274_RS40355"
                     /old_locus_tag="GCM10010349_21000"
     CDS             2577..3581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192852.1"
                     /locus_tag="IE274_RS40355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21000"
                     /product="hypothetical protein"
                     /protein_id="WP_373305723.1"
                     /transl_table=11
                     /translation="MKVVPVGRRAQAASDVPDLIGDAVAAALAECAGDVEAATAALVKR
                     AIPDAMALLDETRKGARYDVVAHPWVPDILRKQTARGADQIWEGRPKWTRAELPPGAHE
                     VTALDINGACLSALKTHLPIGQLEHSTGFDHDHRRAGVHLITPPDWHHDDVLPNPLGNR
                     DEPGPLWVTEPTLRLLLRLSGPKYGMCDAPEIHESFTSGATENLLEKFRIALKDARDGA
                     IAGDEEVTLEYVKAMYSKFVSTMGESHYNRELYRPDWMHLIRSQAFSNLWTKAYKAHRE
                     GLGVVRAMGTDELHVIGDWRSVFPEGRGVTEVKVKDTYTVGTAAEQAPDAQSD"
     gene            complement(3625..3795)
                     /locus_tag="IE274_RS10345"
                     /old_locus_tag="GCM10010349_21010"
     CDS             complement(3625..3795)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047552.1"
                     /locus_tag="IE274_RS10345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21010"
                     /product="hydrophobic protein"
                     /protein_id="WP_190115311.1"
                     /transl_table=11
                     /translation="MVPLLLVLLIALVLFGAGFALKFLWLVAAVVIVAWLVGFIVRPAG
                     AGGRRGRWYRW"
     gene            complement(3867..4157)
                     /locus_tag="IE274_RS10350"
                     /old_locus_tag="GCM10010349_21020"
     CDS             complement(3867..4157)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS10350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_21020"
                     /product="hypothetical protein"
                     /protein_id="WP_198897866.1"
                     /transl_table=11
                     /translation="MHSFLRVFLLGATRVLLIAFLLGGLVVVAGQIVALAAGDPHLMTL
                     FGTDVTEVVCVIAGAAGACSFLLLYVRERGPADGAAGGDDGAADERKSVWD"
     gene            complement(4210..5559)
                     /locus_tag="IE274_RS10355"
                     /old_locus_tag="GCM10010349_21030"
     CDS             complement(4210..5559)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643906.1"
                     /locus_tag="IE274_RS10355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21030"
                     /product="TRAP transporter large permease subunit"
                     /protein_id="WP_190115312.1"
                     /transl_table=11
                     /translation="MNAILALVAFIGVIVIWNVGFRRNIGEAMVLGFLASATFGGTDAP
                     RVAWESLVEGLKSEITFAALAFVFVSELLTRTGLVHRMIDILSSLLGRRKGGSAYAATV
                     ASGLFGAVAHNGAAIVATVGSLAIPWMKRSRASGETAALVLSGNAGVGATFPFSGAFFV
                     LLAAPTVVPVLSSHDVVATLFVTGAWMVGMRLVIAYAIVRWRGVGTMTAADIRPLRQSF
                     GSGWTSLLVLAAVAVPVLLTAGPGSDWATDRLDGLDATDAVPLLMWLPVVMLVAGLLVE
                     RRALPHGGADWWRTLGEIGAKLGLVGVTMVSAFAASEVLARLGLGEQLAPYLKDLQDVP
                     PLVAALVVGLVLVVVAGPLNTTSTLAAVGPVAFAALTAAGIPAHVAFASVIVWASSEGC
                     SPPGAAPLYVAAGIADINPARIFLPVALYYLVPTYLFGVLMAVGVLWVPG"
     gene            complement(5556..6974)
                     /locus_tag="IE274_RS40190"
                     /old_locus_tag="GCM10010349_21040"
     CDS             complement(5556..6974)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024921.5"
                     /locus_tag="IE274_RS40190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21040"
                     /product="class II aldolase/adducin family protein"
                     /protein_id="WP_307822163.1"
                     /transl_table=11
                     /translation="MTTTPRRTPVPGTAPDHPQHPPATAPSHPSPALPHSSARAALVTT
                     AHALAARGLVHGRTGNVSLRTTDGSILITPTGTELGAVAPEDLSVIDADGAHLDGPPPS
                     KEAFLHAAMLRARPDARAVVHTHSPHAAAVSCLDGLDPDDALPPLTAYYAMRVGRLPLL
                     PYFAPGDVRLAGPAEEQARTHAALLLRHHGPVVAAPGLDAALEAVEELEQTARIFLLLR
                     GTEHARLSAEQRAALAPRLPSPVALFSALAIKKALDDVVLEAFTSATGIDVDGVYEPTN
                     VLLEQIAGGARPDVMVGVTSGLAKLADAGVLDRASLRPLARVGIGVAVPPGAPAVDISS
                     TGALVRALTSARSVAYSRTGASGVAFAALLDRLGIAAEVNSRATVVDKGFTALAVTDGR
                     ADLAVQQVSELRFVPDARVVGAFPEEVQHYTDLSIALGAHARDHPGAHALLRHLTAAPA
                     HAAYRAAGLEDPSR"
     gene            complement(6971..8413)
                     /gene="otnK"
                     /locus_tag="IE274_RS10370"
                     /old_locus_tag="GCM10010349_21050"
     CDS             complement(6971..8413)
                     /EC_number="2.7.1.217"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otnK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152064.1"
                     /locus_tag="IE274_RS10370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21050"
                     /product="3-oxo-tetronate kinase"
                     /protein_id="WP_198897865.1"
                     /transl_table=11
                     /translation="MLGVIADDVTGAGDVALALRESGLRTVLYFGVPGADVAPPDGHEA
                     VVVALKSRMAAPAHAVAESLAALEHLREHGVRQVYFKFCSTFDSTPDGNIGPVLDALAD
                     ALDAPAVLLTPSSPQHGRTQYEGRLFVNGVPLAESPMRHHPVTPMTDSSLPRLLRAQTD
                     QPVEVVRWGTVRAGVEAVRAALTDATARGVRYLLADALDEDDLRTLGLATADAPLTAGA
                     AGLAGGLAHAVPGGAPAPYDEVEPLATWPAAVLAGSCSARTLQQLDALRAQGRPLHRLD
                     PVAEPDPATLAGHALDWYDALPPGSPHGAPVLHSSVEPDELRAVQRALGAERAAAVLEE
                     ATGRIAAGLASRGVRRIIAAGGETSGSVVTALGITGAWIGRAGAPGVPWIHPTSGPDIT
                     LLLKSGNFGAPDFLVRASAAPRDHPLPQGHSPSRPPDLSAPTHHSSPPHHAPAPAAPAP
                     PGRSAPPPHTPSPPSRPQGARP"
     gene            complement(8401..9102)
                     /locus_tag="IE274_RS10375"
                     /old_locus_tag="GCM10010349_21060"
     CDS             complement(8401..9102)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643908.1"
                     /locus_tag="IE274_RS10375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21060"
                     /product="hypothetical protein"
                     /protein_id="WP_229909419.1"
                     /transl_table=11
                     /translation="MNTSARPAPPPGRPRIALISATPAAIGPAVAGLADAFPEAEPWNL
                     LDDALLTDAEAQGGLAPALADRMRRLIAYAVAGGARGVLLTCSLYGPVAERAEAAVPVL
                     AADSAAFAAALARGHRRVLVLASFAGALDDSLERFRAAARAAGSPVRAVGQVIAPGERP
                     DPGDADGVLLAQYSLAPHADDLVAALGLPVHTGPHTAARALRSAVGRAAEATSAAGTAT
                     AGTERSTSCSE"
     gene            complement(9099..9986)
                     /locus_tag="IE274_RS10380"
                     /old_locus_tag="GCM10010349_21070"
     CDS             complement(9099..9986)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643909.1"
                     /locus_tag="IE274_RS10380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21070"
                     /product="hydroxypyruvate isomerase family protein"
                     /protein_id="WP_190115313.1"
                     /transl_table=11
                     /translation="MGVAGETAGARPEESSPPPAPRAAPLGPSGLRVPGGPPLAANLKW
                     LFTELSFERRFDAAAEAGFAGVEYADPYPYPPARLRGLLRDAGLRQVLINSPAGEAGSV
                     ERAGLACHPGRVADFRAGVERGLAYATELGAGLLHVLAGVVPPDVSAERAFATYVTNIA
                     WAADRAHGTGVRVVVEAQNRRDAPGYFLRTQARATAVVEAVGRDRAGLLLDLYHAQVTE
                     GDLVRTLDACLPYALHLQIADPPDRTEPGTGEIRWPRVFEALRAAGYDGWIGCEYRPAH
                     GTVAGLGWITEVTA"
     gene            complement(9986..10975)
                     /locus_tag="IE274_RS10385"
                     /old_locus_tag="GCM10010349_21080"
     CDS             complement(9986..10975)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152068.1"
                     /locus_tag="IE274_RS10385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21080"
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="WP_198897864.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 9.2e-58, bitscore:
                     189.8, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLVTTAYLEPGGEVDRLLREAGLRTVFARPADRRAAGRSLASAV
                     AEAGAAGVVAGTDPFPAAVLDAAPGLRVVARCGAGYDNVDVAAATRRGVAVTRTPGANR
                     RSVAEHVLGLMVSCARGIPQNVAEVRAGGWSQPSGRELAGATLGVVGLGSIGRTVARLG
                     LALGMRVVGHDPRLDPAFHAETGVAALSLEEVLGEADFVTLHLALDASTRHLIDGAALR
                     RMRPGAYLINTARGGIVDEEALADVIGEGRLAGAALDVTEREPLPPDSRLRAFGNVLVT
                     GHIAGATAEARSRSSLTAARQVIDVLSGRDAEHVVNPEWAAARAAAAR"
     misc_feature    11066..11081
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    11088..11104
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.01"
                     /tool="antismash"
     gene            11180..11866
                     /locus_tag="IE274_RS10390"
                     /old_locus_tag="GCM10010349_21090"
     CDS             11180..11866
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014626699.1"
                     /locus_tag="IE274_RS10390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21090"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_190115315.1"
                     /transl_table=11
                     /translation="MMATTRPPARQPLADQMYEVLLGQFMDGLWSPGQSLNIGALTREL
                     NVSQTPLREALARLEHTGLVRREALKGYRVAPLFTERELIKLMDARLLLEPAMVQEAAR
                     RTTPEFLDELKESIEELKRCAAAPRSASVRPYWAADERFHLRIAAQCDNPFLETAYRSL
                     GGHVQRFRLFTELGSSEAESPAREHTAVYEAMAAGDADGAAKKMRRHIENAKARALTDR
                     QAVAEA"
     gene            complement(11988..12644)
                     /locus_tag="IE274_RS10395"
                     /old_locus_tag="GCM10010349_21100"
     CDS             complement(11988..12644)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004955182.1"
                     /locus_tag="IE274_RS10395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21100"
                     /product="hypothetical protein"
                     /protein_id="WP_229909420.1"
                     /transl_table=11
                     /translation="MSPREHVKSQPYAGSAPLGAAAARRTRRLSASAVVAGAAVVVCLA
                     GTASAHAAEGAGPVARGGAATATVHSPAAATTVVTEGQVKEAAPGGTLLYPSVTSCLTV
                     TVHLRSGGAVGAHASLFQVPGELRSDQVLERVKALVGTREVASVDVRGAVGAWHPTYFT
                     KAIESYGEGEEVPVPQGQDFAGLTAAVARGLGVPTDAVTVTDVPDGDQVVEVRRY"
     misc_feature    complement(12707..12727)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.91"
                     /tool="antismash"
     gene            complement(12720..14663)
                     /locus_tag="IE274_RS10400"
                     /old_locus_tag="GCM10010349_21110"
     CDS             complement(12720..14663)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004668 - protein-arginine deiminase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015055.5"
                     /locus_tag="IE274_RS10400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21110"
                     /product="protein-arginine deiminase family protein"
                     /protein_id="WP_190115316.1"
                     /transl_table=11
                     /translation="MPKTSSMPQRSSAPQASSVPQATRSRTQATTTAVAVALLAATALA
                     GPPAAAADRPPRADLRADVNQDGRVDVTGGSDEAGEDTWQPGRGAVFLANVDDDSRRCR
                     TRPGDLDRIDPAVDTRLAACNDAADEQVNGVRDRADLAPLRIPPTAVGADATGHVDVPA
                     AQRPYVRLFVRRDGHLRVLRGPLTAAELRAGVEMALEGRDIVRDPRRWNGQVDVTLSVR
                     GQGRESADRVRLKVAPVLFQNDLQRAESVFAAKPGPGSGAIPGSGGIGNGYRPREWQPF
                     ASSLRRAARAAGLADRDVTFTAGTRQWWRDIWRQDMVEPTVASVPAPGGRVHTMRVLLR
                     SPMKWLAPTGGKTTLSRSGRLLFRDFRGPDVGVVQQFTPGREPDGLDLQNATGNFESLP
                     PSPGYPQGRVLYGTDPLRQPDASYVRMIEAQAQQPSLTIDTSWLLVGHVDETVHVVRAD
                     NARGWTLAVADPRQALDLLRRTQRGGEGGQRMFAATTMPDKPTVDGLLADDEFLADNAK
                     AAGHIDGQIRVLLKQTGLTQRDLVRLPVLYTMSTVHPDIPEGAVALSPSIANGLSLTGR
                     DYAAPDPHGPRLQGRDLFRAAAERALATGGVRVHWVENFAWAHLAGGEVHCATNALRDT
                     SGAARWWTRRTT"
     misc_feature    14895..14908
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            14963..16402
                     /locus_tag="IE274_RS10405"
                     /old_locus_tag="GCM10010349_21120"
     CDS             14963..16402
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024907.5"
                     /locus_tag="IE274_RS10405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21120"
                     /product="FG-GAP and VCBS repeat-containing protein"
                     /protein_id="WP_190115317.1"
                     /transl_table=11
                     /translation="MRSHIRRAVVIAAAATTLTGGLPGFTGTQAAQAATTGPAPTRYAD
                     DFNGDGYHDLAIGAPDGAVNVPGADGAPTRALSAGYVTVSYGSKNGAQRTGLKAVTQSS
                     PGVPGGARQNQRFGRTLAGGDFNADGYADLAVASRDEVTLVWGGPTGLKGGTTMSGSAA
                     GPGFGAVLKAGDFTGDGRTDLVVGYSTAIRLHQGPFKADGSPAAVKPVDVGAMFGYADA
                     QKRLAVGRVNKGAIDDLVVLGEERRRGRVLLGGASGLRKTAATVRGGNSVAVADFDKDG
                     YGDIAVGDSAYAIDSERHAGRVQINYGSAGGVDENRGAKTFTEDSPGVPGGVEAGDSFG
                     SDVAAADLNRDGYADLVVGAPGERHATCEHCYISGGGMYVLKGAKRGVTGTGAAFSPYN
                     APGLPRPEGVYRIPQLLKITDLNGDKQPEIALPVRANTSEVWSVGTKDGKIAGAAPTRV
                     VKAPVAAQVPWAGDEFGVLAR"
     gene            complement(16574..17149)
                     /locus_tag="IE274_RS10410"
                     /old_locus_tag="GCM10010349_21130"
     CDS             complement(16574..17149)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717085.1"
                     /locus_tag="IE274_RS10410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21130"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190115318.1"
                     /transl_table=11
                     /translation="MTSTTSARPPGRPRSGVNAAVFAATLSTVEELGYARATVDRIAAA
                     AGIAKSTVYRRWPSKGELIVDCLLDAFGPAPLTGSSRAELMTSTIRWVAAKIGEPGVGD
                     AFAGVFSDAVSDPALREILSTRLQDPYRLALQEALDEPENRVLFFIDVVVGVLLHRMGM
                     TGEPMVEADVDALVDMVLPHFTDGRGKM"
     gene            17330..18298
                     /locus_tag="IE274_RS10415"
                     /old_locus_tag="GCM10010349_21150"
     CDS             17330..18298
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010470712.1"
                     /locus_tag="IE274_RS10415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21150"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190115319.1"
                     /transl_table=11
                     /translation="MSESTTAERPPEPDWLAMTTEELVAYRDAENRFRASSAIRAMTGE
                     PDPGATIRWEKVALPGRELPVRVHRPVTGRDGEGVRRGGLPLVIHVHGGGFVGTAVQCD
                     WVTSHVAARLPAVVVSVEHRLVDPDHPLSAAVDDGWDVLQHVVRHAAQWGVDPERTAVF
                     GESCGALISALAALRAREAGLGLRAQVLVNPAVDVTGSMLDHASAAEHAHTPTLAVPQL
                     RLFQRLAAPPGSDPRALSPLYADDLTGLAPALVVVPTHDPLADHGRRYAERLRAAGTPV
                     RLTEHAEAPHAFLSLPGVVPQAAAARAEIFDFLRASLADLG"
     misc_feature    complement(18797..18807)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    19029..19044
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    19074..19083
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     misc_feature    complement(19134..19151)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.48"
                     /tool="antismash"
     misc_feature    19141..19154
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.2"
                     /tool="antismash"
     misc_feature    complement(19146..19159)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.65"
                     /tool="antismash"
     gene            20001..>23730
                     /locus_tag="IE274_RS10420"
     CDS             20001..>23730
                     /NRPS_PKS="Domain: PKS_AT (262-558). E-value: 4.7e-88.
                     Score: 287.3. Matches aSDomain:
                     nrpspksdomains_IE274_RS10420_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_PP (616-697). E-value: 2.6e-22.
                     Score: 71.0. Matches aSDomain:
                     nrpspksdomains_IE274_RS10420_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (720-1146). E-value:
                     2.4e-183. Score: 601.8. Matches aSDomain:
                     nrpspksdomains_IE274_RS10420_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487282.1"
                     /locus_tag="IE274_RS10420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I polyketide synthase"
                     /protein_id="WP_229909439.1"
                     /sec_met_domain="PKS_AT (E-value: 5.1e-87, bitscore: 287.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-11, bitscore:
                     40.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 8.4e-223, bitscore:
                     735.1, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.6e-90, bitscore:
                     297.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIGTVAVIGVAPAAPVRTEPDPGVWAELTGVTPPADLTAAVESA
                     WTACGDAGIGDDRAGIGVFLAADGAGEGDADELARVLGLLGPCRTAHDPLAEALAAVRS
                     GECGLALVGSDGAHAVLARGDDARTATFAYRLGTDAELPDNVLTLVESALRAGRPAPGR
                     AAAEGPAVPIALTAHSQDALRARAADLCILLDAEPELPLADVALSLATTGPALAERAVF
                     VGADRARLTDELAAFSKGGLPVPGLATGGPAPAAAGGLAFVFPGHGPQWPGMADELMDR
                     FPVFAEQLQACADALTPHVDWPVMDVLRGRTDTPSLDRPDVGQPALWAMMVSLAALWRS
                     WGVVPDAVIGSSAGELPAATVAGALSVEDGARAVAVFGQAQVHLLEHGVMLSVLASADE
                     VRERLTRYDGLDLAAVHAPGSVLVSGVEDQADELLAELAVDGIKARAIDIRIAAHGRQV
                     DAVLDGLRADLAPIEPRPTDVPIYLGTTGERVDPLTLTTDHWCRNLRHTADFESATRAA
                     LAAGHRLLVESSPHPVLTRAVQETAEDVAVDAVVLGTLRRGPGSADHLTAALAVLHAHG
                     VLPDWDAVFAGRDARAVPLPAYPLDAAPAATPAPSLADRLAAAPDRHELLLDLVRAQVA
                     AVAGGDAALSADVDAPLLELGVDSAGAVSLRNLLNAATGLKLPVSAVFDNPTCRGLATH
                     IDRVLLGAPTDDDEAPVAMTGGDDEPIAVVAMSCRLPGGVHSPEDLWELLSAGGDGITA
                     FPADRGWDLDGRYDEDAERVGGYYQREAGFLHEVTEFDPEFFGISPREALAMDPQQRLL
                     LEISWEAIERAGMDPAGLRGSRAGVFVGAMTMDYGPRLHEAPADLEGYLLTGNTASVAS
                     GRLSYTFGFSGPAVTVDTACSSSLAALHLAVQSLRRGECTVALAGGVTVMPSQGMFVEF
                     SRQRALAPDGRSKAFSASADGFGLAEGATMVLLERLSDARRHGHPVLALVKGTAINQDG
                     ASNGLTAPSGPAQRRVIRQALADAGVSAAEVDAVEAHGTGTKLGDPIEADALLATYGQE
                     HPADRPLLLGSVKSNIGHTQAASGVAGLIKMVLALQHGELPKSLHITEPTPHVDWTTGA
                     VSLVTETTPWPEVERPRRAGVSSFGISGTNAHAVLEQAPDEVPADPEPSSASVPLVFSA
                     RSEDALRAHAARLAAVVEQLTPADMAAGLLSRSVFEHRAVVVAGGADALTAVAQGAESA
                     RVAMGVARPAGKVAFVFP"
     misc_feature    20232..20234
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20724..20726
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       20784..20837
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS10420_0001"
                     /evalue="5.50E-07"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE274_RS10420"
                     /protein_end="279"
                     /protein_start="261"
                     /score="21.7"
                     /tool="antismash"
                     /translation="FVFPGHGPQWPGMADELM"
     aSDomain        20787..21674
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: False"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS10420_PKS_AT.1"
                     /evalue="4.70E-88"
                     /label="IE274_RS10420_PKS_AT.1"
                     /locus_tag="IE274_RS10420"
                     /protein_end="558"
                     /protein_start="262"
                     /score="287.3"
                     /specificity="substrate consensus: emal"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: emal"
                     /tool="antismash"
                     /translation="VFPGHGPQWPGMADELMDRFPVFAEQLQACADALTPHVDWPVMDV
                     LRGRTDTPSLDRPDVGQPALWAMMVSLAALWRSWGVVPDAVIGSSAGELPAATVAGALS
                     VEDGARAVAVFGQAQVHLLEHGVMLSVLASADEVRERLTRYDGLDLAAVHAPGSVLVSG
                     VEDQADELLAELAVDGIKARAIDIRIAAHGRQVDAVLDGLRADLAPIEPRPTDVPIYLG
                     TTGERVDPLTLTTDHWCRNLRHTADFESATRAALAAGHRLLVESSPHPVLTRAVQETAE
                     DVAVDAVVLGTLRRG"
     aSModule        20787..22091
                     /complete
                     /domains="nrpspksdomains_IE274_RS10420_PKS_AT.1"
                     /domains="nrpspksdomains_IE274_RS10420_PKS_PP.1"
                     /locus_tags="IE274_RS10420"
                     /monomer_pairings="emal -> emal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS_motif       20949..21020
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS10420_0002"
                     /evalue="4.40E-08"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE274_RS10420"
                     /protein_end="340"
                     /protein_start="316"
                     /score="25.6"
                     /tool="antismash"
                     /translation="LDRPDVGQPALWAMMVSLAALWRS"
     CDS_motif       21024..21125
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS10420_0003"
                     /evalue="6.60E-12"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="IE274_RS10420"
                     /protein_end="375"
                     /protein_start="341"
                     /score="37.7"
                     /tool="antismash"
                     /translation="GVVPDAVIGSSAGELPAATVAGALSVEDGARAVA"
     aSDomain        21849..22091
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS10420_PKS_PP.1"
                     /evalue="2.60E-22"
                     /label="IE274_RS10420_PKS_PP.1"
                     /locus_tag="IE274_RS10420"
                     /protein_end="697"
                     /protein_start="616"
                     /score="71.0"
                     /tool="antismash"
                     /translation="AAAPDRHELLLDLVRAQVAAVAGGDAALSADVDAPLLELGVDSAG
                     AVSLRNLLNAATGLKLPVSAVFDNPTCRGLATHIDR"
     aSDomain        22161..23438
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS10420_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="2.40E-183"
                     /label="IE274_RS10420_PKS_KS.1"
                     /locus_tag="IE274_RS10420"
                     /protein_end="1146"
                     /protein_start="720"
                     /score="601.8"
                     /tool="antismash"
                     /translation="IAVVAMSCRLPGGVHSPEDLWELLSAGGDGITAFPADRGWDLDGR
                     YDEDAERVGGYYQREAGFLHEVTEFDPEFFGISPREALAMDPQQRLLLEISWEAIERAG
                     MDPAGLRGSRAGVFVGAMTMDYGPRLHEAPADLEGYLLTGNTASVASGRLSYTFGFSGP
                     AVTVDTACSSSLAALHLAVQSLRRGECTVALAGGVTVMPSQGMFVEFSRQRALAPDGRS
                     KAFSASADGFGLAEGATMVLLERLSDARRHGHPVLALVKGTAINQDGASNGLTAPSGPA
                     QRRVIRQALADAGVSAAEVDAVEAHGTGTKLGDPIEADALLATYGQEHPADRPLLLGSV
                     KSNIGHTQAASGVAGLIKMVLALQHGELPKSLHITEPTPHVDWTTGAVSLVTETTPWPE
                     VERPRRAGVSSFGISGTNAHAVLEQAP"
     CDS_motif       22644..22691
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS10420_0004"
                     /evalue="1.80E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE274_RS10420"
                     /protein_end="897"
                     /protein_start="881"
                     /score="19.9"
                     /tool="antismash"
                     /translation="GPAVTVDTACSSSLAA"
     CDS_motif       23067..23111
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS10420_0005"
                     /evalue="1.70E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE274_RS10420"
                     /protein_end="1037"
                     /protein_start="1022"
                     /score="13.6"
                     /tool="antismash"
                     /translation="VEAHGTGTKLGDPIE"
     CDS_motif       23172..23216
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS10420_0006"
                     /evalue="5.00E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE274_RS10420"
                     /protein_end="1072"
                     /protein_start="1057"
                     /score="12.4"
                     /tool="antismash"
                     /translation="GSVKSNIGHTQAASG"
ORIGIN
        1 gcgcggcggg ctgctcctgt acgggccgcc gggctgcggg aagacgttca tcgcgcgggc
       61 cgtcgccggt gaactcggcg ccgcgttcct gtcggtgtcg gtcaacgacg tgctcgacat
      121 gtggatcggc aactccgaac gcaacatgca cgagatcttc cggacggccc gccgccaggc
      181 cccgtgcgtg gtcttcctcg acgagctgga cgcgctcggc ggcaagcgca gccgcagcca
      241 gagcagcggc atgcgcaaca ccgtcaacca gctcctgacc gagctggacg gcgtcgacgc
      301 gggcgccaac gagggcgtgt tcgtcctcgc cgccaccaac gtgccctggg acgtggacat
      361 cgcgctgcgc cgccccggcc gcctggaccg caccctgctc gtcctgccgc ccgacggccc
      421 cgcccgcgag gcgatcctcc gctaccacct gcgcgaccgg cccatcgaga acgtcgacct
      481 gggcaagctc gtcaaggcca ccgacggcct gtccggcgcc gacctggccc acctgtgcga
      541 ggccgcggcc gagcgcgcgc tgctcgactc ggcgcgcacc ggcaccgtgc gcctcatcgg
      601 catgaaggac ctgctcgccg ccgcgcagca ggtcctgccg tccaccgagc cgtggttcgc
      661 ctccgcccgc aacgtggcga tgtacgccaa cgacggcggc atgtacgacg acctggtcgc
      721 ccacctcaag aagaagcgga agctgtgacc gcgatacacc ccgccgtgga gcgggccgac
      781 gccctgatcg acctggagcg gtacgacgag gcgggcgccc tgctcgccca gcgcatcgcc
      841 gaggacccgg ccgacgtccg cgcctgggcc aaactctccc gctgccacct cgacgcgggc
      901 cgcccggacg aggcgctcgc agcggccgac gaggccctcg agctcgaccc gcaggacgtg
      961 ggcgggctcc tcatgcggtc ctacgcgctg cgccgcgtcg gcggcgcccg catgcccgag
     1021 gtcgagaccg tcctgcgcga ggtggtccgc ctcgccccgg agtactggct cggccacgcc
     1081 ctcctcgccg acgtcgtgtt catcacgaac gtcgtcagcc gcggccaggc caacggcggc
     1141 caggtcacgc cccaggacat ggacgtctcc gcccgcctcg ccgaggcgca cgtcaaggag
     1201 gcgctgcgcc tgggtcccga ggaggtctac ggccacgagg tcgcgtacaa gatcgcctcg
     1261 ctcgcgggca acgagaccgt cgccgaccag ctcgacctcg ccatcctccg gctcgacccg
     1321 caccacccgc aggccctgga gcgtcagacc cgcaaggccg ccgacacccc cggcgtcaag
     1381 gccgtggagg ccgccgacct gtacgccgcc gggctggccg ccgcgccgga ctccgaggag
     1441 ctgcggcgcg gcctcgacca cgccacgtac cgcatgctgc gcggcgtgcg ctggctcgcc
     1501 ctgctgtgcc tcggcctcgg cgcgtcgatg atcgacctgt tcgccgtcga cggggagacg
     1561 cagcgcgagc tgcccgtcga actcggccaa cggctctggt gcctcgtccc gatgagcgcg
     1621 atctgggccg tcggcgccct gctgcgctac cgccgtcggc gcaccggcgt ccagctcaac
     1681 gtccagtcgc tgctccggcg cggtcgctgg gcccggatcg tggtcgccca ggcggcctgg
     1741 gccatgctct gcaccctcgt catcacccaa gtgccgtgga cggaccgggc cgtgccgatg
     1801 gtggtgttct gggccggtct ggcgccgacg ttcgccacgg tgtggttcga ccggaggaag
     1861 acgggctgac cgggccgggg cagcccgcgg tcggccacgg acattgggta ctggctgctg
     1921 acagccccca ccgtccagga gaagcgccgt gagtgaattc gaggcgatcg acgcgctgct
     1981 cgcggccgcg cccgacgcca acccgctgcc gcccgccgag cggcgccggc tgctgcgcga
     2041 cgagctcggc cggtcgcggg cgcaggtcgc ccgcgccctg ggggtgagct cgtcgacgct
     2101 cgcggcgtgg gagacggggc gcgatcccag cggggagctg cgcagccggt acgtgtactt
     2161 cctgcggcag gccgaggagc gggagcggct gcgccagctg gacgaggagc ggcgccgtgg
     2221 cggtacggcg gatgtcgtgg ccctgggcgg tgaggcgtcg ggggagcccg cggcgactgc
     2281 cgcgcggacc gcgcctgccg atgccgcctc tgccgatgcc ggtgccgacg accagggcga
     2341 actcgccgag ccgagcccct gtgtgctgtg cggtcagccc gcccggcacc aggtggaggg
     2401 ctatccgcag cacctcgacc ccgccgagtg cgccgctccc gcgccggagc ccccggtccc
     2461 cgcgacccgg cccgccaccc cggcccgctg ccgctgcccc gcagctcctc aacgcctccg
     2521 ccccgcagcc caacgcctcc ggcccgcagc gcgtcgtccg cagcccgggc cgaggcatga
     2581 aggtcgtgcc cgtgggccgc cgcgcccagg ccgcgtccga cgtccccgac ctgatcggcg
     2641 acgcggtcgc cgctgcgctc gccgagtgcg ccggggatgt ggaggcggcc acggcggcgc
     2701 tggtgaagcg ggcgatcccg gacgcgatgg cgctgctcga cgagacccgc aagggggcca
     2761 ggtacgacgt cgtcgcgcac ccctgggtcc cggacatcct gcgcaagcag acggcgcgcg
     2821 gtgcggacca gatctgggag ggccgcccca agtggacccg cgccgaactg ccgcccggtg
     2881 cccacgaggt gacggcgctc gacatcaacg gcgcctgtct ttccgccctg aagacgcacc
     2941 tcccgatcgg ccagctggag cactccaccg gcttcgacca cgaccaccgc cgcgcgggcg
     3001 tccatctgat caccccgccc gactggcacc acgacgacgt cctgcccaac ccactgggca
     3061 accgcgacga accgggcccc ctgtgggtca ccgagccgac cctccgcctg ctgctgcgcc
     3121 tgtcgggccc gaagtacggg atgtgcgacg cgccggagat ccacgagtcg ttcacgtccg
     3181 gcgccacgga gaacctcctt gagaagttcc gcatcgccct gaaggacgcc cgggacgggg
     3241 cgatcgccgg ggacgaagag gtgacgctgg agtacgtgaa ggcgatgtac tcgaagttcg
     3301 tctccacgat gggcgagtcc cactacaacc gtgagctgta ccgccccgac tggatgcacc
     3361 tcatccgctc ccaggcgttc tccaacctct ggacgaaggc gtacaaggcg caccgcgagg
     3421 gcctgggtgt cgtgcgcgcc atgggcaccg acgaactcca cgtcatcggc gactggcggt
     3481 cggtgttccc cgagggccgc ggggtgaccg aggtgaaggt caaggacacc tacaccgtcg
     3541 gcaccgccgc agaacaggca ccggacgccc agtccgactg actgggcgtc cggccgagcg
     3601 ggcggcgcgg gcctccgccg ggactcacca gcggtaccag cgccccctgc gtccgccggc
     3661 cccggccggg cggacgatga agcccaccag ccacgccacg atgacgacgg ccgccaccag
     3721 ccacaggaac ttgagggcga agcccgcgcc gaacagcacg agagcgatca gcagaaccag
     3781 cagcaaagga accatgtcta tcgacctccg ccaccccgag tgcccgatgg cgcgggcgtt
     3841 atgcgggcgg tgacggccgg tccggctcag tcccagacgc tcttcctctc gtccgccgcc
     3901 ccgtcgtccc cgcccgcggc gccgtcggcg ggaccccgct cccgtacgta cagaagcagg
     3961 aacgaacagg cgcccgccgc gcccgcgatg acgcacacca cctcggtgac gtcggtgccg
     4021 aacagcgtca tcaggtgcgg gtcgcccgcc gcgagggcca cgatctgacc cgcgaccacg
     4081 acgaggccgc cgagcaggaa ggcgatgagc aggacgcggg tcgcgcccag caggaagaca
     4141 cgcaggaagc tgtgcacggt ggctctccgt ttctccgtgt gcggctcggc cggggacccc
     4201 gtgtgcggct cagccgggta cccacagcac gcccaccgcc atcaggacgc cgaacaggta
     4261 ggtcggcacc aggtagtaca gggccacggg caggaagatg cgggccgggt tgatgtcggc
     4321 gatgcccgcg gccacgtaca ggggcgccgc gcccggcggt gagcagccct cggacgaggc
     4381 ccacacgatc accgacgcga acgcgacgtg ggcggggatg ccggcggcgg tgagcgcggc
     4441 gaaggcgacg gggccgacgg ccgcgagggt ggacgtggtg ttgagggggc ccgcgacgac
     4501 gacgaggacc aggcccacca cgagcgccgc gaccaggggc gggacgtcct ggaggtcctt
     4561 gaggtacggg gcgagttgct cgccgaggcc gagacgggcg aggacctccg aggccgcgaa
     4621 cgccgacacc atcgtcacgc ccacgagccc cagcttcgcg ccgatctcgc ccagcgtccg
     4681 ccaccagtcg gcgccgccgt gcggcagcgc ccgccgctcc accaggagcc ctgcgaccag
     4741 catcaccacc ggcagccaca tgagcagcgg caccgcgtcc gtggcgtcga gcccgtcgag
     4801 gcggtccgtc gcccagtcgc tgccgggccc cgccgtgagg aggaccggca cggcgacggc
     4861 tgcgaggacg aggagcgacg tccagcccga gccgaacgac tggcgcagcg gccggatgtc
     4921 cgccgcggtc atcgtcccca cgccccgcca gcgcacgatc gcgtacgcga tgacgagccg
     4981 catcccgacc atccacgccc cggtgacgaa cagcgtggcc acgacgtcgt gcgaggacag
     5041 caccggcacc accgtcggcg cggcgagcag cacgaagaac gcgccgctga acgggaacgt
     5101 cgcgccgacg cccgcgttgc cggaaagcac cagcgcggct gtctcgccgc tggcccgcga
     5161 ccgcttcatc cacgggatgg ccagcgagcc gacggtggcg acgatcgccg cgccgttgtg
     5221 cgcgacggct ccgaacaggc cggaggccac cgtcgccgcg tacgcggaac cgcccttgcg
     5281 gcggccgagc agtgagctga ggatgtcgat catccggtgc acgaggcccg tacgcgtgag
     5341 cagttcgctg acgaagacga acgcgagcgc cgcgaacgtg atctccgact tgaggccctc
     5401 gacgaggctc tcccacgcca cgcgcggcgc gtcggtcccg ccgaacgtcg cgctcgccag
     5461 gaacccgagg accatcgcct cgccgatgtt ccgccggaat cccacattcc agatgacgat
     5521 gacgccgatg aacgccacca gggcgaggat cgcgttcatc ggcttgggtc ctcgagtccg
     5581 gccgcgcggt acgcggcgtg ggccggggcg gcggtgaggt ggcgcaggag ggcgtgggcc
     5641 ccggggtggt ccctggcgtg tgcgcccagc gcgatcgaca ggtcggtgta gtgctggacc
     5701 tcctcgggga acgcgccgac gacccgcgcg tccggcacga accgcagctc gctcacctgc
     5761 tgcacggcca ggtccgcccg cccgtccgtg accgcgaggg ccgtgaaccc cttgtcgacc
     5821 accgtggccc gggagttgac ctcggccgcg atgccgagcc ggtcgagcag cgcggcgaac
     5881 gcgacaccgc tcgcgccggt acgcgagtac gccaccgacc gggcggacgt cagcgcccgc
     5941 acgagcgccc ccgtgctgga aatatccacg gcgggcgcac ccggcggcac ggccaccccg
     6001 atgcccacgc gcgcgagcgg ccgcagcgag gcccggtcga gcacgcccgc gtcggccagc
     6061 ttcgccaggc cgctcgtcac cccgaccatg acgtcggggc gcgcgccgcc cgcgatctgc
     6121 tcaagcagga cgttcgtggg ctcgtacacc ccgtcgacgt cgatcccggt ggcgctggtg
     6181 aacgcctcca ggacgacgtc gtccagggcc ttcttgatgg cgagcgcgct gaacagggcc
     6241 acgggggagg ggaggcgagg ggcgagggcg gcacgctgct ccgcactgag gcgggcgtgc
     6301 tcggtaccgc gcaggagcag gaagatccgc gctgtctgct ccagttcctc gacggcctcc
     6361 aacgccgcgt cgagcccggg agccgccacc accggaccgt ggtgccgcag cagcagcgcc
     6421 gcgtgggtac gggcctgctc ctcggccggg cccgcgagtc ggacgtcgcc cggcgcgaag
     6481 taggggagca gggggagccg tccgacgcgc atggcgtagt aggcggtgag cggggggagc
     6541 gcgtcgtccg ggtcgaggcc gtcgaggcac gacaccgcgg cggcgtgcgg ggagtgagtg
     6601 tggacgacgg cccgcgcgtc ggggcgtgcg cgcagcatcg cggcgtgcag gaacgcctct
     6661 ttggacggcg gcggtccgtc gaggtgcgcg ccgtcggcgt cgatgacgga caggtcctcg
     6721 ggagccacgg ccccgagctc ggtgccggtc ggggtgatga ggatgctgcc gtcggtggta
     6781 cgcagcgaca cgttgccggt gcgtccgtgc acgagcccgc gggcggccag ggcgtgggcg
     6841 gtggtgacga gggcggcgcg tgcggaggag tgggggagtg cgggcgaggg gtgcgaaggg
     6901 gccgtggcgg gcgggtgttg ggggtggtcg ggcgcggtgc cagggacggg ggtccggcgc
     6961 ggggtggtgg tcatgggcgg gctccttggg ggcggcttgg cggggagggg gtgtgcggtg
     7021 ggggagcgga gcggccagga ggtgcggggg cggccggtgc gggcgcgtgg tgcgggggac
     7081 tggagtggtg tgtgggagcg gagaggtccg ggggccggga gggggagtgg ccctggggca
     7141 gggggtggtc gcggggtgct gccgaggccc tgaccaggaa gtccggggcg ccgaagttgc
     7201 ccgacttgag gaggagcgtg atgtcggggc ccgaggtggg gtggatccac gggacgccgg
     7261 gggccccggc gcggccgatc caggcgccgg tgatgccgag tgcggtgacc acggagcccg
     7321 aggtctcgcc gcccgccgcg atgatgcggc gtacgccccg ggacgcgagc ccggcggcga
     7381 tgcggccggt ggcctcctcc aggacggccg ccgcccgttc ggcgcccaat gcccgttgga
     7441 cggcccggag ttcgtcgggc tcgacggagg agtggagcac gggtgcgccg tggggtgagc
     7501 cgggcggcag ggcgtcgtac cagtcgaggg cgtgtccggc cagcgttgcc gggtcgggct
     7561 cggccacggg gtcgaggcgg tgcagcgggc ggccctgggc gcgcagggcg tcgagttgtt
     7621 ggagggtgcg cgcggagcag cttccggcga ggacggccgc gggccaggtg gccaggggct
     7681 ccacctcgtc gtacggggcg ggggcgccgc ccgggacggc gtgtgccagc ccgcccgcga
     7741 gtccggccgc cccggcggtg agcggcgcgt cggccgtggc gaggccgagg gtgcgcaggt
     7801 cgtcctcgtc gagcgcgtcg gcgagcaggt agcggacgcc gcgcgccgtc gcgtcggtga
     7861 gcgccgcgcg gacggcctcg acgcccgcgc gcacggtgcc ccaccggacc acctccaccg
     7921 gctggtccgt ctgggcccgg agaagccggg gcagcgacga gtcggtcatc ggcgtcaccg
     7981 ggtggtggcg catcggcgac tcggccaacg gcacgccgtt cacgaagagc cggccctcgt
     8041 actgggtgcg gccgtgctgc ggtgagctgg gggtgaggag cacggccggg gcgtccaggg
     8101 cgtcggcgag cgcgtccagg accgggccga tgttgccgtc gggcgtggag tcgaaggtcg
     8161 agcagaactt gaagtagacc tgccgcacgc cgtgttcgcg caggtgctcc agggccgcca
     8221 gcgactccgc gacggcgtgt gcgggggccg ccatccggct cttgagcgcg acgacgaccg
     8281 cctcgtgccc gtccggcggc gccacgtccg cgcccggcac cccgaagtac aggacggtcc
     8341 gcagcccgct ctcccgcagg gccagggcca catcaccggc cccggtcacg tcatcggcga
     8401 tcactccgag cacgacgtgc tcctctctgt tcctgccgtc gctgttcctg ccgccgaggt
     8461 ggcctccgcg gcccggccca ccgcgctgcg cagggcgcgg gccgccgtgt gcggcccggt
     8521 gtggacgggc agcccgagtg cggcaaccag gtcgtcggcg tgcggcgcca acgagtactg
     8581 ggccagcagc accccgtccg catccccggg atccgggcgc tcgcccgggg cgatcacctg
     8641 gccgacggcc cgcacgggcg acccggcagc ccgcgcggcg gcccggaacc gctccagcga
     8701 gtcgtccaac gccccggcga aggacgcgag gacgagcaca cgacggtggc cccgggcgag
     8761 cgccgcggcg aacgcggcgg agtccgccgc gagcaccggg acggccgcct cggcgcgctc
     8821 ggccaccggc ccgtagagcg agcacgtcag gagtacgccc cgggcgccgc ccgccacggc
     8881 gtacgcgatg agccgccgca tccggtcggc gagcgccgga gccagtccgc cctgtgcctc
     8941 ggcgtcggtg agcagcgcgt cgtcgagcag gttccagggc tcggcctcgg ggaaggcgtc
     9001 ggcgagcccg gcgacggcgg ggccgatcgc cgccggggtg gcgctgatga gcgcgatgcg
     9061 cgggcgccca ggtgggggag cggggcgggc ggaggtgttc acgccgtcac ctccgtgatc
     9121 cagccgagcc cggcgaccgt gccgtgggcg ggccggtact cgcagccgat ccagccgtcg
     9181 tacccggccg cgcgcagcgc ctcgaagacc cgcggccagc ggatctcgcc ggtgccgggc
     9241 tcggtgcggt cgggcgggtc ggcgatctgg aggtgcaggg cgtacggcag gcaggcgtcc
     9301 agggtccgta cgagatcgcc ctcggtgacc tgggcgtggt agaggtcgag gagcagcccg
     9361 gcccggtcgc ggccgacggc ttccacgacg gccgtcgccc gggcctgggt gcggaggaag
     9421 tagccgggcg cgtcacgccg gttctgcgcc tcgacgacga cgcgcacccc ggtgccgtgg
     9481 gcgcggtcgg cggcccaggc gatgttcgtg acgtaggtgg cgaaggcgcg ctcggcgctc
     9541 acgtccggcg gtacgacccc ggccaggacg tgcaggagcc cggcgcccag ctcggtggcg
     9601 tacgcaaggc cgcgctcgac cccggcacgg aagtccgcga cgcggcccgg gtggcaggcg
     9661 agccccgccc gctccaccga accggcctcc ccggcgggcg agttgatgag aacctgccgc
     9721 aacccagcgt cccgcagcag cccgcgcagt cgcgccgggg gatatggata cgggtcggcg
     9781 tactcgaccc ccgcgaagcc cgcctcggcc gccgcgtcga agcgccgctc gaaggacagc
     9841 tccgtgaaga gccacttgag gttggcggcg aggggcggac cgccggggac ccggaggccg
     9901 ctcgggccga gcggcgccgc gcgcggcgcc gggggagggg acgattcctc gggccgcgcc
     9961 ccagccgtct caccagcgac ccccatcacc gcgccgccgc cgcgcgcgcc gccgcccact
    10021 ccggattcac gacgtgctcg gcatcccgtc ccgacagcac gtcgatcacc tgccgggccg
    10081 ccgtcaggct ggagcgcgac cgggcctccg ccgtcgcgcc cgcgatgtgt ccggtcacca
    10141 ggacattgcc gaacgcccgc agccgggagt ccggcggcag cggctcacgc tccgtcacat
    10201 ccagggcggc gcccgcgagt cggccctcgc cgatcacgtc ggcgagggcc tcctcgtcga
    10261 cgatgccgcc ccgcgcggtg ttgatgaggt acgcgccggg ccgcatccgg cgcagcgcgg
    10321 ccccgtcgat gaggtgccgg gtcgacgcgt cgagggcgag gtgcagcgtc acgaagtcgg
    10381 cctcgccgag cacctcttca agggacagcg ccgccacccc ggtctccgcg tggaacgccg
    10441 ggtccaggcg cgggtcgtgc cccacgacgc gcatgccgag ggccaggccg aggcgcgcca
    10501 cggtccgccc gatcgagccg agcccgacga cgccgagcgt cgcgcccgcc aactcccgcc
    10561 cgctgggctg cgaccagcca cccgcccgta cctcggcgac gttctgcgga atgccccgcg
    10621 cgcagctcac catcaggccg agcacatgct cggcgacgga ccggcggttg gcgccggggg
    10681 tgcgtgtgac ggcgacgccg cggcgggtgg cggcggccac gtccacgttg tcgtacccgg
    10741 cgccgcagcg ggcgacgacc cgcagcccgg gggcggcatc gagcaccgcc gccgggaacg
    10801 ggtcggtccc cgcgacgacg cccgcggcac ccgcctcggc gacggccgag gccagcgagc
    10861 ggcctgccgc gcgccggtcc gcgggccgcg cgaagaccgt ccgcagaccg gcttcccgca
    10921 gcagccggtc gacctcgccg ccgggttcga gatacgccgt ggtcacgagc accacggccg
    10981 atgagtcatc gggcaagggg tccgggcaat ccggggagtc cggggagcgc agagagtccg
    11041 gggagtgcga ggggcgctgg gcaggcatga ggatcctcct cgatctatcg ctatactata
    11101 gcgcgaagca aaatagtata ggatcgagct gtgatcaaga gggggagcgg ctgcgctagt
    11161 gtcgggcacc gaaggaggca tgatggctac gacgcgcccg cccgcccggc aacccctggc
    11221 cgaccagatg tacgaggtac tgctcgggca gttcatggac ggtctgtggt caccggggca
    11281 gtccctcaac atcggggccc tgacccggga gctgaacgtc agtcagacac cgctccgcga
    11341 ggccctggcc cgcctggagc acacgggtct ggtgcgccgc gaggcgctca agggctaccg
    11401 cgtcgcaccg ctcttcaccg agcgcgagct gatcaagctg atggacgcgc ggctcctcct
    11461 ggaaccggcg atggtccagg aggcggcgcg ccgcaccacg ccggagttcc tggacgaact
    11521 gaaggagagc atcgaggagc tgaagcgctg cgcggcggcg ccgcgttcgg cctcggtgcg
    11581 gccgtactgg gccgccgacg agcgcttcca cctgcgcatc gccgcgcagt gcgacaaccc
    11641 gttcctggag accgcctacc gttccctcgg cggccacgtc cagcgcttcc gcctcttcac
    11701 cgaactcggc tcctccgagg ccgagtcccc ggcgcgcgag cacacggccg tgtacgaggc
    11761 gatggcggcg ggcgacgcgg acggcgccgc gaagaagatg cggcggcaca tcgagaacgc
    11821 gaaggcgcgg gcgctgacgg accgccaggc ggtggcggag gcctgacggc cagagccgtc
    11881 aggcctggca ccggacgggg ggccgtcagg cccggcactg gacggccggg tccgatcccg
    11941 gcgtgtgcgg gcccgatccc ggcgtctgcg gacccgggcc cgcgcggtca gtaccgccgc
    12001 acctccacga cctgatcacc atcgggtacg tccgtgaccg tcaccgcgtc cgtcggcacc
    12061 ccgagccccc gcgccaccgc cgccgtgaga ccggcgaagt cctggccctg gggcacggga
    12121 acctcctcgc cctcgccgta gctctcgatc gccttggtga agtaggtcgg atgccaggcc
    12181 ccgaccgcgc ccctgacgtc caccgatgcc acctcgcggg tgccgaccag ggccttgacg
    12241 cgctccagga cctggtccga gcgcagctcg cccggcacct ggaacaggct cgcgtgcgcg
    12301 cccaccgcgc cgcccgagcg gaggtggacg gtgacggtca gacagctggt gacgctcggg
    12361 tacaggagcg tcccgccggg cgccgcctcc ttgacctggc cctccgtcac cacggtcgtc
    12421 gccgccgcgg ggctgtggac ggtggccgtg gcggcgccgc cacgggcgac cggcccggca
    12481 ccctcggccg cgtgggccga tgcggtgccc gcgaggcaga ccacgaccgc cgcaccggcc
    12541 accacggccg acgccgacag ccgccgcgtg cgccgggccg ccgccgcgcc gaggggcgcc
    12601 gacccggcgt acggctgcga cttcacgtgc tcacgtgggg acaactggaa caactcctct
    12661 gcggcagagc gcccgcggcg cactcggccg cgggctgcga ccgatcactc tatgcggtgc
    12721 tatgtcgtgc gccgcgtcca ccatcgggcc gccccggagg tgtcgcgcag ggcgttcgtc
    12781 gcgcagtgca cctcgccgcc ggccaggtgc gcccaggcga agttctccac ccagtgcacg
    12841 cgcaccccgc ccgtggccag ggccctctcg gccgccgcgc ggaacaggtc gcggccctgc
    12901 agccggggcc cgtgggggtc gggtgcggcg tagtcccggc cggtgaggga caggccgttg
    12961 gcgatgctgg gggagagggc gacggcgccc tcggggatgt cggggtggac ggtggacatg
    13021 gtgtagagga cgggcagccg caccaggtcg cgctgggtca gaccggtctg cttcagcagg
    13081 acgcggatct ggccgtcgat gtgtcccgcg gccttcgcgt tgtcggcgag gaactcgtcg
    13141 tcggccagga gcccgtcgac ggtgggcttg tcgggcatgg tcgtcgcggc gaacatccgc
    13201 tgcccgccct cgcccccgcg ctgggtgcgc cgcagcaggt cgagggcctg gcgggggtcg
    13261 gcgacggcga gcgtccagcc gcgcgcgttg tccgcccgca ccacgtgcac ggtctcgtcc
    13321 acgtgcccca cgagcagcca ggacgtgtcg atcgtgaggg acggctgctg ggcctgcgcc
    13381 tcgatcatcc gcacgtacga ggcgtcgggc tgccggagcg gatcggtgcc gtacaggacc
    13441 cggccctgcg gatatcccgg ggagggcggc agggactcga agttgccggt ggcgttctgc
    13501 aggtcgaggc cgtccggctc gcggccgggc gtgaactgct gcaccacgcc gacgtccggc
    13561 ccccggaagt cacggaacag cagccgcccg gaccggctca gggtcgtctt cccgcccgtg
    13621 ggcgccagcc acttcatggg actgcgcaag agcacgcgca tggtgtgcac ccggccgccg
    13681 ggcgcgggca cgctcgccac ggtcggctcc accatgtcct gccgccagat gtcgcgccac
    13741 cactgccggg taccggccgt gaacgtgacg tcccggtcgg cgaggcccgc ggcgcgcgcg
    13801 gcccggcgca gggaggaggc gaagggctgc cactcgcgcg gccggtagcc gttgccgatc
    13861 ccgccggagc cggggatggc gccgctgccc gggccgggct tggcggcgaa gacgctctcg
    13921 gcgcgctgga ggtcgttctg gaacagcacg ggcgccacct tcagccgcac gcgatcggcg
    13981 ctctcgcgtc cctggccgcg cacgctgagg gtcacgtcga cctggccgtt ccagcggcgc
    14041 gggtcacgca cgatgtcgcg cccctccagg gccatttcga ccccggcgcg cagctcggcc
    14101 gcggtgagcg gtccccgcag gacgcgcagg tggccgtcgc gccggacgaa gagccggacg
    14161 tacgggcgct gcgccgcggg cacgtcgaca tggccggtcg cgtccgcgcc caccgccgtg
    14221 ggcggaatgc gcagcggcgc cagatcggcc cggtcgcgca ccccgttgac ctgctcgtcg
    14281 gccgcgtcgt tgcaggcggc gaggcgggtg tccacggccg ggtcgatccg gtccaggtcg
    14341 ccggggcgcg tccggcagcg gcgcgagtcg tcgtcgacgt tcgcgaggaa caccgccccg
    14401 cgccccggct gccaggtgtc ctcacccgcc tcgtcggagc cgccggtgac gtcgacgcgg
    14461 ccgtcctggt tcacgtcggc gcgcaggtcc gcgcggggtg ggcggtcggc ggcggcggcc
    14521 ggtggtccgg cgagggcggt ggcggcgagc agggcgacgg cgacggccgt tgtggtggcc
    14581 tgtgtccgtg acctcgtcgc ctggggcacg ctcgatgcct ggggcgcgct cgatctctgg
    14641 ggcatgctcg atgtcttggg cacgacgggg cctcctggag gcggcgggtg cgagcaggtg
    14701 cggagaatgt ccgcattcca tgctcgtccg cgtggagcgg ctgttcatcg tgccgagtgc
    14761 ggagcccgcc actacatcga tgtggctacc gccccgtcgc cccgtcctgc tcggggtgtg
    14821 ctcccggaac ccgtacgtca tcccccgccc gagccaccgg ctccgggtgg gcaaacggaa
    14881 gtaccgcgaa gatccgcaca accgttcgtg cgcggcaggg gtcttggggg tgcaaccaat
    14941 cgagttccta gggggaacgg acgtgcgcag ccacatccgt cgcgcggtcg tgatcgccgc
    15001 ggcggccacg acactcaccg ggggtctgcc gggcttcacc ggtacccagg cggcccaggc
    15061 cgccaccacg ggccccgcgc ccacccggta cgccgacgac ttcaacggcg acgggtacca
    15121 cgacctcgcc atcggcgccc cggacggcgc ggtgaacgtc cccggcgcgg acggcgcgcc
    15181 cacccgggcc ctgagcgcgg gctacgtcac cgtctcgtac ggctcgaaga acggcgccca
    15241 gaggaccggc ctgaaggccg tcacccagag cagccccggc gtgccgggcg gcgcgcggca
    15301 gaaccagcgg ttcggccgga cgctcgcagg cggcgacttc aacgccgacg gctacgcgga
    15361 cctcgccgtc gcgtcccgcg acgaggtcac cctggtctgg ggcggcccca ccggcctcaa
    15421 gggcggcacc acgatgtccg gcagcgcggc cgggcccggc ttcggcgcgg tcctgaaggc
    15481 cggtgacttc accggggacg gcaggaccga cctggtcgtc ggctactcca cggcgatccg
    15541 cctgcaccag ggcccgttca aggccgacgg ctcgcccgcc gcggtcaagc cggtggacgt
    15601 gggcgccatg ttcggctacg ccgacgcaca gaagcggctc gccgtgggac gggtcaacaa
    15661 gggcgccatc gacgacctcg tggtgctcgg cgaggagcgc aggcggggcc gggtgctgct
    15721 cggcggcgcg tccgggctgc gcaagaccgc ggccaccgtc cgcggcggca acagcgtcgc
    15781 ggtcgccgac ttcgacaagg acgggtacgg cgacatcgcg gtcggcgact cggcgtacgc
    15841 gatcgactcc gagcggcacg cgggccgggt ccagatcaac tacggctccg ccggcggcgt
    15901 ggacgagaac cgcggtgcca agacgttcac cgaggacagc cccggcgtcc cgggcggagt
    15961 cgaggcgggg gacagcttcg gcagcgacgt cgccgcggcc gacctcaacc gggacggcta
    16021 cgcggatctg gtcgtcggcg ctcccggcga gcggcacgcc acctgcgagc actgctacat
    16081 cagcggcggc ggcatgtacg tgctcaaggg cgcgaagagg ggcgtgaccg gcaccggcgc
    16141 cgcgttctcc ccctacaacg cgcccggcct gccccgtccc gagggtgtct accgcatccc
    16201 gcagctcctc aagatcacgg atctgaacgg ggacaagcag cccgagatcg ccctcccggt
    16261 ccgggcgaac acgtccgagg tgtggtcggt cggcacgaag gacggcaaga tcgccggggc
    16321 cgcgcccacc cgcgtggtga aggctccggt ggctgctcag gtgccgtggg ccggggacga
    16381 gttcggggtg ttggcgcgct gacggtcccg tagccgctcg tacccgttca tggccccagg
    16441 ggccctgtcg ctcgactcgt cggcgcaggg ctcctggggc atctccatgt ctgggggcgg
    16501 gtgtcgggtg acgggcgccg gatgtctccc gacgtcggat gtccccgccg ggcggacgtg
    16561 gcccgacggg gcatcacatc ttgccgcggc cgtcggtgaa gtgcggcagg accatgtcca
    16621 ccagggcgtc gacatcggcc tcgaccatcg gctcgccggt catgcccatc cggtgcagca
    16681 gcacgccgac cacgacgtcg atgaagaaca ggacccggtt ctccggctcg tccagcgcct
    16741 cctggagcgc cagccggtac gggtcctgca gccgcgtgga caggatctcc cgcagggccg
    16801 ggtcgctgac ggcgtcgctg aacacgccgg cgaacgcgtc gcccaccccc ggctcaccga
    16861 tcttcgccgc gacccagcgg atggtcgagg tcatcagctc ggcgcgactg gagcccgtca
    16921 gcggcgccgg gccgaacgcg tccaggaggc agtccacgat cagctcgccc ttcgacggcc
    16981 agcgccggta gaccgtcgac ttcgcgatcc cggccgcggc ggcgatgcga tcgacggtgg
    17041 cgcgcgcgta gccgagttcc tcgactgtgc tcaacgtggc ggcgaagaca gcggcgttga
    17101 cgccggagcg cggacggccg ggcggcctgg cggatgtggt cgatgtcata gccgcacgat
    17161 acctcttttc gctaccttgg gtatcgatac ctgaagtcgc gaaactctct cgcggcgggc
    17221 tcgcgaacga gccgggcaac gagctggcca acgggctgac gcatgagctg gtcaacgagc
    17281 ccacccacga actcactggc gacgagaccc ctttgagcaa ggagaaggca tgagcgagag
    17341 caccaccgcg gagcggccgc cggagcccga ctggctggcg atgaccaccg aggagctggt
    17401 cgcctaccgc gacgcggaga accgcttccg ggcgtccagc gcgatccggg cgatgaccgg
    17461 ggagccggac cccggcgcca cgatccgatg ggagaaggtg gcactgcccg gccgtgaact
    17521 cccggtccgg gtgcaccgac cggtcaccgg gcgcgacggc gaaggcgtgc ggcggggcgg
    17581 gctgccgctc gtcatccacg tgcacggggg cgggttcgtg ggtacggccg tgcagtgcga
    17641 ctgggtcacc agtcacgtgg ccgcccgact gcccgccgtc gtcgtctcgg tggagcaccg
    17701 cctcgtcgac ccggaccatc cgctgtcggc cgccgtcgac gacggctggg acgtgctcca
    17761 gcacgtggtg cggcacgccg cgcagtgggg cgtggacccg gagcggaccg ccgtcttcgg
    17821 cgagagctgc ggcgcgttga tcagcgccct ggcggcgctc cgggccaggg aggccggcct
    17881 ggggctgcgg gcgcaggtgc tggtgaaccc cgctgtcgac gtgaccgggt cgatgctcga
    17941 ccacgcctcg gccgccgagc acgcgcacac cccgaccctc gccgtgccgc agctgcgact
    18001 cttccaacgg ctcgcggctc ccccgggatc cgaccctcgc gcgctctcgc cgctgtacgc
    18061 cgacgacctc accgggcttg ccccggcgct cgtggtggtg ccgacccacg acccgttggc
    18121 cgaccacggc cgccgctacg ccgaacgact gcgggcggcc gggacgcccg tgcggctcac
    18181 cgaacacgcc gaagcgccgc acgcgttcct cagcctgccg ggcgtggtcc cgcaggccgc
    18241 ggccgcgcgc gcggagatct tcgacttcct ccgggcttcc ctcgccgacc tgggctagcc
    18301 cggaggcccg catccgccgc cccgtgaggt gaccgccaac tcgcggggcg gcggccgttc
    18361 ttgggccgga cgccaccttc ttcacgcctc ttcaccaggg cgtcacctgc gcgacagggt
    18421 gacgccctgt ccgcgcgtgg gcacgttgtg agatgaacca cgatgatcgc gcaggagggc
    18481 tgaaacgggc aagaagcgga gcgctggtgt ggccaaacgg gcacaacctg gtccggatgt
    18541 gcccgtttcg tcgagtgctg cccggtgcgt cgtgtgtgtc cgggtcgggt gtcgcggatg
    18601 cgaactgggt ggagttgatg ccaggtagcg gaggcgttgt ggctcttcgc ttcggcatat
    18661 atagagggcg ctcgcggtgc cgggcagcag ttcttacgcg ccagtaagcg agcgctgccg
    18721 cgccgccgat agccacaaat ggacggggtg gtgcgggcaa aggcaggtcc gatactgttg
    18781 cgccaggcac ggaccagtga catcgcattc acctgaccat gagcgatcca cccgcgtatc
    18841 cgatcgggca cccccggagg agcattcact ttgcctcccc gcatcgagcc cgaagcccat
    18901 atggagtcca cccaaaggga gagcacggcc cagtgacccg cgatgccggt tctggtactt
    18961 ccgagcgagc cttcccggct gccgtgtgga gaccggggcc gggttgctgt ccctactcaa
    19021 aagtaggtag tgactggcgt cacgcggcac ttggcagatg gagtgcgcgc cgccattttt
    19081 tgcttacccc gacgtattga ttgcctctgc ccgaccgctg tcttgtcgag ttcgaaacag
    19141 agttttaaca atacctttcc gcgtgtcccg cgggtaatga actcgcccat ggttgcgctg
    19201 tcctggcgca ccgcttcgtc ggcgactggc agtcggcgcg acacccgtat ccggcccggc
    19261 ggcgcctagg tcgcagcacc cgtgccatgg cccggtcgtg agccgcgggt ggcgccgccg
    19321 gagtctttgt cgtcccagct cacggtggtg cccggacctc gcgccgtggt gtctccgggc
    19381 aggccgctgc cgtgttccag gcccaggtca tcggtgttcc cggcggtaac gtcacgggtg
    19441 tgctcggcgc tttccgctac gcgcgcggtg ggtgtttcga cgcggatgcg gataggtgtc
    19501 cccatgttaa gggatgcgtg cgacccgagg ttgacggtcg cacggcagtc gggcatcgag
    19561 aggggtaccg gatgttcccc ttccgcttat agcggtgtgc cctttcagtt gccccaaagg
    19621 gcagcggagt ggctgcgtcc agcgggtgag agctggggtt ttgcgtaccc tggcagcgcc
    19681 gggggcgggg ttaattcctc aagtcggccc cgtaaatttc gtgagcccgg gcgcgccgac
    19741 tcgcgccaac acggcgccaa cgggtattcc tcgcgcgggc gcgttacgac acgttgtccg
    19801 acacgcggca gactggaaat agccgtcgac cgaccggaaa tatacgccag ttgacaattt
    19861 ctggagcgct ggtcttgact tgcgccagtt gtcggtgcgg tttggctgag aagtgtgcga
    19921 gccaattcgg gccaatgatg cgtgtgttca ttagcggacg attgacgagg gcagaggctg
    19981 ccatgtgcga attggcacga gtggacatcg gcactgtcgc cgtcatcgga gtcgcgcctg
    20041 cggcaccggt gcggaccgag ccggatcccg gagtttgggc cgaactgacc ggtgtgacac
    20101 cgccggcgga cctgaccgcc gcggtggagt cggcgtggac ggcctgtggg gacgcgggca
    20161 tcggtgacga ccgggcgggc atcggcgtct tcctggccgc cgacggcgcc ggcgaaggcg
    20221 acgcggacga gttagcgcgg gtgctcggcc tcctcggccc gtgccggacc gcgcacgacc
    20281 cgctcgccga ggccctcgcc gcggtgcgtt ccggcgaatg cggcctggcc ctcgtcgggt
    20341 cggacggtgc ccacgccgtg ctcgcgaggg gcgacgacgc ccggaccgcg accttcgcct
    20401 accggctcgg caccgacgcc gagttgcctg acaacgttct caccctcgtc gagtccgccc
    20461 tgcgcgcggg ccgccccgcc cccggccgcg ccgccgccga aggccccgcc gtcccgatcg
    20521 cgctgacggc gcacagccag gacgccctgc gggcccgcgc cgccgacctg tgcatactcc
    20581 tcgacgccga gccggaactc ccgctcgccg acgtcgcctt gtccctcgcc acgaccggcc
    20641 ccgcgctcgc cgagcgcgcc gtgttcgtcg gcgccgaccg ggcccgcctc accgacgagc
    20701 tggccgcctt cagcaagggc ggattacccg taccgggact cgccaccggc ggccccgccc
    20761 cggccgcggc gggcggcctc gccttcgtgt tccccgggca cgggccccaa tggccgggca
    20821 tggccgacga gttgatggac cgcttcccgg tgttcgccga gcagctgcag gcctgcgcgg
    20881 acgccctcac accgcacgtg gactggcccg tcatggacgt cctgcgcggc cgcacggaca
    20941 cgccgtcgct cgaccggccg gacgtgggac agcccgcact ctgggcgatg atggtgtccc
    21001 tggccgccct gtggcggtcc tggggcgtgg tgcccgacgc cgtgatcggc tccagcgccg
    21061 gcgagctccc ggccgcgacg gtcgcgggcg cactgtccgt cgaggacggt gcgcgggccg
    21121 tggccgtgtt cggccaggcg caggtgcacc tgctcgaaca cggcgtgatg ctgtccgtcc
    21181 tcgcgtccgc cgacgaggta cgcgaacggc tgacccgcta cgacggcctc gacctcgccg
    21241 ccgtgcacgc ccccggctcg gtcctggtct ccggcgtcga ggaccaggcc gacgaactcc
    21301 tcgccgaact ggccgtggac ggcatcaagg ccagggccat cgacatccgc atcgcggcgc
    21361 acggccgcca ggtcgacgcg gtcctcgacg ggctgcgcgc cgacctcgcc ccgatcgagc
    21421 cccgcccgac ggacgtgccg atctacctgg gcacaacggg cgagcgggtc gacccgctca
    21481 cgctcaccac ggaccactgg tgccgcaacc tgcgccacac cgccgacttc gagagcgcca
    21541 cccgcgccgc acttgccgcg ggccaccgcc tgctcgtcga gtcgagcccg caccccgtcc
    21601 tcaccagggc tgtgcaggag accgccgagg acgtcgccgt ggacgccgtc gtcctcggga
    21661 cgctgcgccg gggcccgggc agcgccgacc acctgaccgc cgcgctggcc gtgctgcacg
    21721 cgcacggcgt actccccgac tgggacgcgg tgttcgcggg ccgggacgcc cgcgcggtgc
    21781 cgctgcccgc ctatccgctg gacgcggcgc ccgcagccac ccccgccccg tccctcgccg
    21841 accggctcgc ggccgccccc gaccgccacg aactgctcct cgacctggtc cgcgcgcagg
    21901 tcgccgccgt cgcgggcggg gacgccgcgc tctccgccga cgtggacgcg ccgctcctgg
    21961 agctgggcgt cgactcggcg ggcgcggtgt ccctgcgcaa cctcctgaac gccgccaccg
    22021 gcctgaagct gcccgtgtcc gcggtgttcg acaacccgac gtgccgaggc ctcgccacgc
    22081 acatcgaccg ggtcctgctc ggcgcgccca ccgacgacga cgaggcgccg gtcgccatga
    22141 cgggcggcga cgacgagccg atcgccgtcg tcgcgatgag ctgccgcctg cccggcggcg
    22201 tacacagccc cgaggacctg tgggagctgc tgtccgcggg cggcgacggc atcaccgcgt
    22261 tccccgccga ccgcggctgg gacctggacg gacgctacga cgaggacgcc gagcgggtgg
    22321 gcggctacta ccagcgcgaa gccggattcc tgcacgaagt caccgagttc gacccggagt
    22381 tcttcgggat atcgccgcgc gaggccctcg ccatggaccc gcagcagcgg ctgctcctgg
    22441 agatctcctg ggaggcgatc gagcgcgcgg gcatggaccc cgcggggctg cggggcagcc
    22501 gcgcgggcgt gttcgtgggc gcgatgacga tggactacgg gccgcgactg cacgaggcgc
    22561 ccgcggacct ggagggctac ctcctcaccg gcaacaccgc gagcgtcgcc tccggcaggc
    22621 tctcctacac gttcggcttc tcagggcccg ccgtcaccgt cgacacggcg tgctcgtcgt
    22681 cgctggccgc cctgcacctg gccgtgcagt cgctgcgccg tggagagtgc accgtcgcgc
    22741 tcgcgggcgg cgtcacggtc atgccgtcgc agggcatgtt cgtggagttc agcaggcagc
    22801 gcgcgctggc ccccgacggc cgcagcaagg cgttctcggc cagcgcggac gggttcggcc
    22861 tcgccgaggg cgccaccatg gtgctcctcg agcggctctc cgacgcccgc cgccacggcc
    22921 accccgtgct cgcgctggtc aagggcaccg ccatcaacca ggacggcgcg tccaacggcc
    22981 tcaccgcccc cagcggcccc gcgcagcgcc gggtgatccg gcaggcgctc gccgacgcgg
    23041 gcgtgtccgc cgccgaggtc gacgccgtcg aggcgcacgg caccggcacg aagctgggcg
    23101 acccgatcga ggcggacgcg ctgctcgcca cctacggcca ggagcacccg gccgaccggc
    23161 cgctgctgct cggctcggtg aagtcgaaca tcggccacac gcaggccgcg tccggcgtcg
    23221 cgggcctgat caagatggtg ctcgcgctgc agcacggcga gctgcccaag agcctgcaca
    23281 tcaccgagcc caccccgcac gtggactgga cgacgggcgc ggtgtcgctc gtcaccgaga
    23341 ccacgccgtg gccggaggtc gagcgccccc ggcgggccgg tgtgtcctcg ttcggcatca
    23401 gcggcaccaa cgcccacgcc gtcctggagc aggcgcccga cgaggttccg gccgacccgg
    23461 agccgtcgtc ggcgtccgtg ccgctggtgt tctccgcgcg ctcggaggac gccctgcgcg
    23521 cccacgccgc ccgactcgcc gctgtcgtgg agcagttgac gcccgccgac atggcggccg
    23581 gtctgctgtc ccgctcggtc ttcgaacacc gggccgtggt ggtcgcgggc ggcgccgacg
    23641 cgctgacggc ggtggcccag ggggccgagt ccgcccgggt ggcgatgggt gtcgcgcggc
    23701 ctgcgggcaa ggtggcgttc gtgttccccg
//
