LOCUS       NZ_BMVR01000002        21116 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000002
VERSION     NZ_BMVR01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 777077)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 366173
            Orig. end                         :: 387289
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21116
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21116
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21116
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11116](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11116)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            273..473
                     /locus_tag="IE274_RS05445"
                     /old_locus_tag="GCM10010349_10960"
     CDS             273..473
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058292.1"
                     /locus_tag="IE274_RS05445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_10960"
                     /product="YbdD/YjiX family protein"
                     /protein_id="WP_190114416.1"
                     /transl_table=11
                     /translation="MSGPLRRAVRGLRWYVRELTDESAYERYVAHLRKGHPDAVVPSRR
                     AFERMRTDRQESDPRQGFRCC"
     gene            596..877
                     /locus_tag="IE274_RS05450"
                     /old_locus_tag="GCM10010349_10980"
     CDS             596..877
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992859.1"
                     /locus_tag="IE274_RS05450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_10980"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_190114417.1"
                     /transl_table=11
                     /translation="MSDAPEAPVAPEVRQPVVTPVRVIIALCLVAPFVAMLWVSSYAKA
                     DPDFIGIPFFYWYQMLWVLISTALTLIAYQLWQRDQRGRKALKDGASR"
     gene            874..2496
                     /gene="mctP"
                     /locus_tag="IE274_RS05455"
                     /old_locus_tag="GCM10010349_10990"
     CDS             874..2496
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006848 - pyruvate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mctP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130767.1"
                     /locus_tag="IE274_RS05455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_10990"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_190114418.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFIFFFLAVTVMGFLASRWRRAENEQSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     EDTNWFIKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIVVAIIYIPIKLGG
                     FDDIFSAAGEKFSATNEATGKPVGSLVPGDAGTWTYATLALGSALALFMYPHSITATLS
                     SRSRDVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVENGQLAIPQLFEDMFPDWFTG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIRPDATPAQETKVSKLVSLLVKVGAL
                     AFVLTMDKTVAINFQLLGGIWILQTMPALVGGLFTRWFHRWALLAGWAVGMVYGTVAAY
                     GVASPTQKHFGGSSKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLKAVGAPDGIDETSP
                     EDYTADAGDKGVAVELPKVGAGH"
     misc_feature    2657..2671
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.28"
                     /tool="antismash"
     gene            2671..3387
                     /locus_tag="IE274_RS05460"
                     /old_locus_tag="GCM10010349_11000"
     CDS             2671..3387
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972796.1"
                     /locus_tag="IE274_RS05460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11000"
                     /product="hypothetical protein"
                     /protein_id="WP_190114419.1"
                     /transl_table=11
                     /translation="MPRPRLLLPTALLLLAPLALTGCGSEHAGSENPDSGNAGSEHAGS
                     GAGPTPSRADLEDRARAAQTRTAHVYVTEADGFTLAEQSVGVLGDDGFQAVYVAKEGGA
                     QIKVGVERGTVDGKTCRSVHPPAGRCEKDGKGWYRTPGSADSSGSAGSSGASGSTGSWH
                     AYARSEHGLRVQLSADPRLVDRDTLRAAAEQAHRADAAELDAVLPKKTSPATPVERGDI
                     PRDGDGAPQDPPGAGG"
     misc_feature    3534..3548
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 24.51"
                     /tool="antismash"
     misc_feature    3565..3579
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     regulatory      3601..3696
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    3712..3727
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.79"
                     /tool="antismash"
     gene            3847..6285
                     /locus_tag="IE274_RS05465"
                     /old_locus_tag="GCM10010349_11010"
     CDS             3847..6285
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="IE274_RS05465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11010"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_190114420.1"
                     /transl_table=11
                     /translation="MTIAPAEPASAQAQKSAQAGPQAEAEQAAQTTDGPGTALLRTLTD
                     LTADLPDADPGRVAAAALRGRSAKADAVELRELATEAAAGLISEDPAYSRLAARLLTIG
                     IREEAASQGVTSFSQSVAVGHREGLIADRTAEFTTLHADRLDGLVDAALADGADRRFGY
                     FGLRTLHSRYLLRHPITRKVVETPQHFMLRVAAGLAEDASERALDEVAALYRLMSRLDY
                     LPSSPTLFNSGTRHPQMSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRS
                     RGSLIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDN
                     TGEDARRTHNLNLAHWIPDEFMRRVAADQPWSLFSPADVPELVDLWGEQFDAAYKKAEA
                     AGLAQKTIPARDLYGRMMRTLAQTGNGWMTFKDTANRTANQTAEPGHTVHSSNLCTEIL
                     EVTDDGETAVCNLGSVNLGAFVDTERGDIDWERLDATVRTAVTFLDRVVDINFYPTEQA
                     GRSNAKWRPVGLGAMGLQDVFFQLKLPFDSPEARALSTRIAERIMLASYEASADLAERN
                     GPLPAWEKTRTARGVLHPDHYGVELTWPERWAALRERIAVTGMRNSLLLAIAPTATIAS
                     IAGVYECIEPQVSNLFKRETLSGEFLQVNSYLVQELKRLGVWDAQTREALRESNGSVQG
                     FTWVPQDVRDLYRTAWELPQRGLIDMAADRTPFLDQAQSLNLFLETPTIGKLSSMYAYA
                     WQRGLKTTYYLRSRPATRIARAAGGSAAAAAPTPVPQQVSDPDAIACSLENPESCEACQ
                     "
     gene            6276..7295
                     /locus_tag="IE274_RS05470"
                     /old_locus_tag="GCM10010349_11020"
     CDS             6276..7295
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005312161.1"
                     /locus_tag="IE274_RS05470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11020"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_372447265.1"
                     /transl_table=11
                     /translation="MPVIMSDKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVD
                     LHSDVADLAKLTPGEQHMIGRLVAFFATGDSIVSNNLVLTLYKHINSPEARLYLSRQLF
                     EEAVHVQFYLTLLDTYLPDPDDRAAAFDAVEEIPSIREKAQFCFKWINEVEKIERLETK
                     ADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMNFA
                     FEVVDTVRKEEPDLFDDELKEQVTDMLREAVDAELQFGRDLCGEGLPGMNTESMRQYLE
                     CVADQRLVRLGFPALYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGSVSFDDEF"
     gene            complement(7208..7489)
                     /locus_tag="IE274_RS05475"
                     /old_locus_tag="GCM10010349_11030"
     CDS             complement(7208..7489)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047586.1"
                     /locus_tag="IE274_RS05475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11030"
                     /product="hypothetical protein"
                     /protein_id="WP_190114422.1"
                     /transl_table=11
                     /translation="MNAHDALNTLAVLGVFLLMALPSLIGHAHDRRIDRQLRAAERGDG
                     PHLGQVPEPGRNPAPAPDRTQNSSSKETEPSTATWYADGRRSKKLVSS"
     gene            7583..8554
                     /locus_tag="IE274_RS05480"
                     /old_locus_tag="GCM10010349_11040"
     CDS             7583..8554
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326964.1"
                     /locus_tag="IE274_RS05480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11040"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_190114423.1"
                     /transl_table=11
                     /translation="MLNNVAAVVLDGVHPFELGVVCEVFGLDRSDEGLPVYDFAVASAE
                     GPVLSTHAGYTITAAHGLDRLEEADLITVPAGDSYVTRDFPPDLLAALRRAADRGTRVL
                     SVCTGVFVLAAAGLLDGRRCAVHWRHAEELKRRHPRAIVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRRENGTEVANAIARRMIVPPHRDGGQAQYIERPLPRTACDTVGGVLAWME
                     RHLDREQTVDQLAARAHMSPRTFARRFQQETGTTPYRWLLRQRLLRAQELLEATDETVD
                     AIAGRAGFGNAAALRHQFVRALGTTPNAYRRTFRGPEADSAA"
     gene            complement(8625..10004)
                     /locus_tag="IE274_RS05485"
                     /old_locus_tag="GCM10010349_11050"
     CDS             complement(8625..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644064.1"
                     /locus_tag="IE274_RS05485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11050"
                     /product="cytochrome P450"
                     /protein_id="WP_190114424.1"
                     /sec_met_domain="p450 (E-value: 1.4e-73, bitscore: 243.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVEFTASAIPATTPTAQLRTPPVVQGGAPVLGHAWNLVRDPLGF
                     LADLRDHGDLVRIRLGPKTAYAVCDPELVGRMLKSPEYIVGGPLWDTLEVLLGKGVATS
                     NGPLHRRQRRMMQPAFRPERIADYARVMAEEAQATAARWGHGGTVDVSAEMFRTAVRIV
                     SRSLLEVDSIGEKADRISDSLHTVFEGLYRRMVLSVGPLYRVPTPANRRFERALADLHA
                     LVDEIIAERRALGTGQEQDLLADLLRARDETGEPIADQEIHDHVVSLVVAGAENVASTL
                     AWTFHLLTEHPEQERRLVEEVNSVTSGRPVAFADLKELPHTRNVVTEAMRIRPAAWIFT
                     RRSVAETSLGGYRIPADADIVYSVYAMQRDPRSFDRHLEFDPDRWNPERAASVPEFAMM
                     PFSVGNRKCPGDHFSLAELTLILATVLPKWRLSPVAATDTGTKVGITLHPKKLVLRAER
                     R"
     gene            complement(10001..11116)
                     /locus_tag="IE274_RS05490"
                     /old_locus_tag="GCM10010349_11060"
     CDS             complement(10001..11116)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644065.1"
                     /locus_tag="IE274_RS05490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11060"
                     /product="multidrug MFS transporter"
                     /protein_id="WP_229909240.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-63, bitscore: 210.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPAVRTRAVSVPPPLALPVVESEFPRHLHPYWPKLQENSRAWLL
                     EKRLMSPDKVAAYADSLCYTDLVAGYYIGAPDELLAAIADLSSWFFGWDDRHDRDAVHG
                     RTAQWRRLCQGLHTTLEHPRRQLGHPDPLVAGFADCVLRLYSHLGPRWNARFARHFHPV
                     IDAYDHEFGNRRTGTVPGVEAYVELRRLTFAHWVWIDLLEPTARYELPDAVRKHPAYRA
                     AALATQDFSAWYNDLCSLPKELAGDEVHNLGISLMQHEGLSLQETVAEVHRRVRDCVSD
                     FLAVEPELLLLADEMKADGKQGKRTGAALQSCVFNMRNWFSSVYWFHHESGRYRVDSWD
                     DRALPPYVSDAGAPEFPSTDLAEIDPSGGEE"
     gene            complement(11544..12197)
                     /gene="def"
                     /locus_tag="IE274_RS05495"
                     /old_locus_tag="GCM10010349_11070"
     CDS             complement(11544..12197)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644066.1"
                     /locus_tag="IE274_RS05495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11070"
                     /product="peptide deformylase"
                     /protein_id="WP_190114426.1"
                     /transl_table=11
                     /translation="MAQDTEQQQPGGGVLPVDDEGFVVDTEDAEERETAFRERGTSRPI
                     TVVGNPVLHKECKDVTAFDDELARLVDDMFASQRTAQGVGLAANQIGVDLKVFVYDCMD
                     DEGVRHVGVVCNPVLQELPADQRHLDESGEGCLSVPTAYADLARPDYAVVTGQDEKGNA
                     IKVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMEEGTPRYPVVPND"
     gene            complement(12430..13410)
                     /locus_tag="IE274_RS05500"
                     /old_locus_tag="GCM10010349_11080"
     CDS             complement(12430..13410)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="IE274_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11080"
                     /product="hypothetical protein"
                     /protein_id="WP_030359852.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRSAGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGVAATGEPMGMELGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTAAGHAYPVFDEIELWAPSPVPTWVVLLEAATEEDRD
                     ALERLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     SPGALWVPERECGLAAPAGLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            complement(13575..14903)
                     /locus_tag="IE274_RS05505"
                     /old_locus_tag="GCM10010349_11090"
     CDS             complement(13575..14903)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845561.1"
                     /locus_tag="IE274_RS05505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11090"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_229909242.1"
                     /transl_table=11
                     /translation="MTPRSGVRLPVVVRGAAVLLAVAALGATLWSGVAEPGIALGFGVL
                     IAVGELARWGSGAEREPAPLGSAGALAYALLGECGGRATHHGVLQVVAVVVAAGLVGAV
                     PQVALGRDPSLDHIARRVLAVAFAALCFQPLYNSGRLEAVAGHGPGYAAVIVILLALTA
                     LCDAVLAAALAHARSGWPFGPLLRDELRGMAGIGSAVCATGAVMALAVAVAGLWALPVF
                     SLPLLLTQLAFRRYVGARTTYRQTIASLARATEIAGYTPPGHARRVADLSRATGRELGL
                     SGADLGVLEHAALMHDIGQLSLVDPVPAGATAALPEAEQRRIALLGGAVVRQTGVAAGV
                     AVVVERQADPYRDQPLTARIVRAANAYDEMAREHGPQGPLSALERLRLATGRDYQPEVV
                     EALARVLARGRGRPGERRQAAEPPGPPQEAPDGLPQGPAGERG"
     gene            complement(14900..16315)
                     /locus_tag="IE274_RS05510"
                     /old_locus_tag="GCM10010349_11100"
     CDS             complement(14900..16315)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061544.1"
                     /locus_tag="IE274_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11100"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_190114427.1"
                     /transl_table=11
                     /translation="MRSVPARARGYVIGVALGGAACVAPALGPGTRWTVVALLAALYAG
                     GERAVRHEVAARTFFPVLLAGVFLLPPAAAALVAVPGALCARVERQPRRLRRAWRAAQL
                     ALAAWAAGQAYAAFDGPAAASAPDFPYVLLPAAAAVLAFAGVLAALDGGILVTAERVPA
                     RTAWRGLLPRSLAPVAVHGLAGLMMAVLWQSPYGPPAALLVLLPMGVSCWVFAQYHRER
                     AAHQATIRALVQAVDLKDRYTRGHSERVGRAAVLIARELGMDDARVEVLRFAGILHDVG
                     KLGVPTRLLRKDGPLTPQERRVIELHPEYGHEMVRGIGFLGDARAAILHHHERIDGSGY
                     PYGLTGTQIPESARVVAVADAFDAMTSSRSYRRARPVPAAVAELERCAGVQFDAEMVGA
                     LVRALARHGWDAEVTAGGGAEEREPGGPEGRGAAGPGGGSVTGAAPAAVVSGSGSAPGG
                     DARRPEAYRPLRR"
     misc_feature    complement(16421..16436)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            complement(16561..16869)
                     /gene="rsrA"
                     /locus_tag="IE274_RS05515"
                     /old_locus_tag="GCM10010349_11110"
     CDS             complement(16561..16869)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061545.1"
                     /locus_tag="IE274_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11110"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_190114428.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDHEMPDSDCTKFETHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPADLRAKVMGRIDLIRSGQAVPDQDLTATPVDGTA"
     gene            complement(16866..17540)
                     /locus_tag="IE274_RS05520"
                     /old_locus_tag="GCM10010349_11120"
     CDS             complement(16866..17540)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="IE274_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11120"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_030359848.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTENGHAEQSGQPEETAAQRTARFERDALTFLDQMY
                     SAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQRE
                     PQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKNALQAIPEEFRIAVYLA
                     DVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEAKGS
                     GS"
     gene            complement(17760..18365)
                     /locus_tag="IE274_RS05525"
                     /old_locus_tag="GCM10010349_11130"
     CDS             complement(17760..18365)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973757.1"
                     /locus_tag="IE274_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11130"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_190114741.1"
                     /transl_table=11
                     /translation="MTWHPAKRARLVLAVGHGAGGGIEARDLRAIAAALPAHGVTVALV
                     EQPWRVAGKKVAPAPKTLDVGWRGVWPALAEPGLPVVAGGRSAGARVACRTATGLGAAA
                     VLALSFPLHPPGKPEKSRADELLGAGVPTLVVQGGNDPFGKPAEFPEATAHDTAYELVE
                     IPFGDHSFAVPKRADIGQDEAVKRITDAVARWAGMLSP"
     gene            complement(18496..19311)
                     /locus_tag="IE274_RS05530"
                     /old_locus_tag="GCM10010349_11140"
     CDS             complement(18496..19311)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="IE274_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11140"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_190114429.1"
                     /transl_table=11
                     /translation="MCGRYASSRRPEDLAGIFEIEKWDPEEALEPDYNVAPTKEVYAVL
                     DRPLKDAEERRPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPSYRRAFTTRR
                     CVLPADGYYEWVTGEAERELEVEGKKKRPRKQPYFVTPADGSVFAMAGLYEFWRDKTLP
                     DEHPLAWWVTCSVITTEAETTPLGVAPQEGPKTLADIHPRMPLMLTPDRWDAWLDPSRT
                     DVDDLRSLLEPPPAGLMRAYPVSTAVSSVKNNGPELLTELEGPEEGTLF"
     gene            19417..20139
                     /locus_tag="IE274_RS05535"
                     /old_locus_tag="GCM10010349_11150"
     CDS             19417..20139
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009308536.1"
                     /locus_tag="IE274_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_11150"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_190114430.1"
                     /transl_table=11
                     /translation="MHTTASASLGDLWDRLTGTQAAPEQWLVLVTGAVALAAVLPHAVW
                     RVARNAVTIAHEGGHGLVALLTGRRLDGIRLHSDTSGLTVSRGRPTGLGMILTAAAGYT
                     APPLLGLAGAALLGEGRITALLWVATALLVAMLVMIRNAYGALTVIVSGGVFLAVSWLA
                     DTDVQAAFAYTVVWFLLLGGVRPAFELQAKRRHGGAGDSDADQLSRLTHVPAGMWLFLF
                     HAVSLCSLIGGARWMLTA"
     misc_feature    complement(20269..20283)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
ORIGIN
        1 ccgcccgcca agtcgatgga cgacatgcac accgtcgtca ccaactccac ggtggacggc
       61 gtcctttcgg ccgcgctcgc cctcctcatc gtcatcgtca tcgccgacgc gctccgcatc
      121 tgcgtccgcc acatccgcga tccgctgtcg tcgaagctga gcgaggcgcc gttcgtggag
      181 tccaagacgg ccgcgcccgc cggtcttttc gcgacgaagg aggagaaggc ggaaatcgcg
      241 gcggccgagg agcgcgagcc ggcgggctcg ccatgagcgg gccactgcgg cgcgcggtgc
      301 gcggactccg ttggtacgta agggagttga ccgacgagtc cgcgtacgag cggtacgtgg
      361 cgcacctccg caaaggtcat ccggacgccg tcgtgccgag ccgccgggcg ttcgagcgga
      421 tgcggacgga ccggcaggag tcggacccac ggcagggctt ccgctgctgc tgagcaggca
      481 tgacagcgtt tccggtaccc gtccgttata cggacggggg ttccgtaccg cgagatctct
      541 gacttagatt tcccgaacgt taagaacggg ataagtgagg gaacggagcc gcgggatgtc
      601 agatgcgcct gaagcgccag ttgcgcccga agtgagacaa ccggtggtca cgccggtccg
      661 cgtgatcatc gccctctgcc tcgtggcgcc cttcgtggcg atgctctggg tgagttcgta
      721 cgcgaaggcc gacccggact tcatcgggat cccgttcttc tactggtacc agatgctctg
      781 ggtgctgatc tcgaccgcgc tcacactgat cgcctaccag ctgtggcagc gtgaccagcg
      841 cggccgcaag gccctgaagg acggagcgtc ccggtgaacg acggcgtgaa cggcgtcgcg
      901 ctcgccgtct tcatcttctt cttcctcgcg gtcaccgtga tgggcttcct ggcgtcccgc
      961 tggcgccggg ccgagaacga gcagagcctc gacgaatggg gcctgggcgg ccggtcgttc
     1021 ggcacctggg tgacctggtt cctgctcggc ggcgacctgt acaccgcgta caccttcgtg
     1081 gctgtcccgg cggcgatcta cgcggcgggc gcggccggct tcttcgccgt gccgtacacc
     1141 atcctcgtct acccgctgat cttcaccttc ctgccccgcc tgtggtccgt ctcgcacaag
     1201 cacgggtacg tgacgacgtc ggacttcgtc cggggccggt tcggctccaa ggggctgtcg
     1261 ctggccgtgg cggtcaccgg catcctcgcg acgatgccgt acatcgcgct ccaactggtc
     1321 ggcatccagg ccgtgctcga cgtgatgggc gtcggcggcg gcgaggacac caactggttc
     1381 atcaaggacc tgccgctgct catcgccttc ggcgtgctcg ccgcgtacac ctactcgtcc
     1441 gggctgcggg cgcccgcgct gatcgcgttc gtgaaggaca ccctgatcta catcgtgatc
     1501 gtggtggcca tcatctacat cccgatcaag ctcggcgggt tcgacgacat cttcagcgcg
     1561 gcgggcgaga agttctccgc gaccaacgag gccaccggca aacccgtcgg ctccctcgtc
     1621 ccgggcgacg cgggcacctg gacgtacgcg acgctggccc tcggctccgc gctcgcgctg
     1681 ttcatgtacc cgcactcgat caccgcgacg ctgtcctcgc gcagccgcga cgtgatccgc
     1741 cgcaacacca ccatcctgcc gctgtactcg ctgatgctcg gcctgctcgc gctgctcggg
     1801 ttcatggcga tcgcggccgg agtgaaggtc gagaacgggc agttggcgat cccgcagctg
     1861 ttcgaggaca tgttcccgga ctggttcacg ggcgtggcgt tcgcggcgat cggcatcggc
     1921 gcgctcgtcc cggcggccat catgtcgatc gcggccgcga atctcttcac ccgcaacatc
     1981 tacaaggact tcatcaggcc cgacgcgacc cccgcgcagg agacgaaggt ctccaagctg
     2041 gtctcgctcc tggtgaaggt gggcgcgctc gccttcgtcc tcaccatgga caagaccgtg
     2101 gccatcaact tccagctgct gggcggcatc tggatcctgc agaccatgcc cgccctcgtc
     2161 ggcggcctgt tcacgcgctg gttccaccgg tgggcgctgc tcgccgggtg ggcggtcggc
     2221 atggtctacg ggacggtcgc cgcgtacggg gtcgcctcgc cgacgcagaa gcacttcggc
     2281 ggctcctcca aggagatccc gggcatcggt gagatcggct acatcggcct gacggccttc
     2341 gtcctgaacg tcgtcgtgac cgtcgtcctc accttcgtcc tgaaggccgt gggcgccccc
     2401 gacggcatcg acgagacgtc cccggaggac tacacggcgg acgccggtga caagggcgtg
     2461 gcggtggagc tgccgaaggt cggagccggg cactgaccgc ccggggcatc gccccgccct
     2521 cccaggaggc cgcccgcagg ccgcccgcag cccgccccgc agagggctcc tgaagaggcc
     2581 agtcgaagag gccgccgcgt tccgtccggg acgcggcggc cttcgccgtg ccgcctccgg
     2641 cgccgaaccg gcgtacggaa gaatgggtcc atgccgcgtc ctcgcctcct gctccccacc
     2701 gccctgctgc tgctcgcgcc cctcgccctc accggctgcg gctccgagca cgcgggctct
     2761 gagaacccgg actccgggaa cgcaggctcc gagcacgcgg gctccggcgc cggaccgacg
     2821 ccctcccgcg ccgacctgga ggaccgcgcc cgcgccgccc agacccggac ggcgcacgtg
     2881 tacgtgaccg aggccgacgg gttcacgctg gcggagcagt ccgtgggcgt cctcggggac
     2941 gacggcttcc aggcggtgta cgtggcgaag gagggcggcg cgcagatcaa ggtcggcgtc
     3001 gagcggggca ccgtcgacgg caagacctgc cggagcgtcc atcccccggc cgggcgctgc
     3061 gagaaggacg ggaagggctg gtaccgcacg cccggctccg cggactcgtc gggttccgcg
     3121 ggttcgtcgg gcgcgtcggg ctccaccggc tcctggcacg cgtacgcccg ctccgagcac
     3181 ggcctgcgcg tccagctctc cgccgacccc cgcctcgtgg accgcgacac gctgcgcgcc
     3241 gccgccgagc aggcccaccg cgcggacgcc gccgagctgg acgccgtact gccgaagaag
     3301 acctcgcccg ccacgccggt ggagcgcggc gacatccccc gcgacggcga cggcgcgccc
     3361 caggacccgc cgggcgcggg cggctgaacg acgccgcggt gacggccgag tgggccctca
     3421 gcgaccgctg agcgggcccc gggcggcagc cggacgcccc cttggaatgc cacgccccgc
     3481 ccccgagttg aggttcaggg cgccccgtcc cgcgacaacg ccactaccct ccgacacaac
     3541 atctaggggt ggcaccgaaa gccagcacaa gatgtatgct cgtgctcgct gtcgccgcag
     3601 gggaatccgg tgcaagtccg gaactgtccc gcaacggtgt actggtacgc atttgtgtgc
     3661 tcgcgcccgc aacatgcgcc ggtgagtccg acgacctgtc gacagcgcac ctggaccgtc
     3721 cggtcctggt gccgagacgt ccgggcctcg cggaatgggt tggtggacgc ggagtcgccc
     3781 ctgcgcgggc gcagccgcgc cgtgccgccc tccgaaggcc cagagccgag cgagggagag
     3841 caccacgtga ccatcgcgcc cgccgaaccc gcgtcagcgc aggcccagaa gtcggcgcag
     3901 gccggcccgc aggccgaggc cgagcaggcc gcgcagacca ccgacggccc agggaccgcc
     3961 ctgctgcgca ccctgaccga cctcaccgcc gacctccccg acgccgaccc cggccgggtc
     4021 gccgccgccg cgctgcgcgg ccgctcggcc aaggcggacg cggtggagct gcgggagctg
     4081 gcgaccgagg ccgccgccgg gttgatctcg gaggaccccg cgtactcccg gctcgcggcc
     4141 cggctcctga ccatcggtat ccgcgaggaa gccgcctcgc agggcgtcac gtcgttctcc
     4201 cagtccgtcg ccgtcggcca ccgcgagggc ctgatcgcgg accgcaccgc cgagttcacc
     4261 accctgcacg cggaccgcct cgacggcctc gtggacgccg cgctcgccga tggcgccgac
     4321 cgccgcttcg gctacttcgg cctgcgcacc ctgcacagcc gctatctgct ccggcacccg
     4381 atcacccgca aggtcgtcga gaccccgcag cacttcatgc tgcgcgtggc cgccggtctc
     4441 gccgaggacg cctccgagcg cgccctcgac gaagtcgccg cgctctaccg cctgatgagc
     4501 cgtctcgact acctgccgtc ctcgccgacg ctcttcaact ccggcacccg gcacccgcag
     4561 atgtcgtcct gctatctcct cgactcgccg ctcgacgagc tggactccat ctacgaccgc
     4621 taccaccagg tcgcgcgact ctccaagcac gcgggcggca tcggcctctc gtactcccgc
     4681 atccgctcgc gcggctccct gatccgcggc accaacgggc actccaacgg catcgtgccg
     4741 ttcctgaaga cgctcgacgc ctccgtcgcc gccgtgaacc agggcggccg ccgcaagggc
     4801 gccgccgcgg tctacctgga gacctggcac tccgacatcg aggagttcct ggagctgcgg
     4861 gacaacaccg gcgaggacgc ccggcgcacc cacaacctga acctggcgca ctggatcccg
     4921 gacgagttca tgcgccgcgt cgccgccgac cagccgtggt cgctgttctc cccggccgac
     4981 gtgcccgagc tcgtcgacct gtggggcgag cagttcgacg ccgcgtacaa gaaggcggag
     5041 gcggccggtc tcgcgcagaa gaccatcccc gcccgtgacc tgtacggccg catgatgcgc
     5101 accctcgcgc agaccggcaa cggctggatg accttcaagg acaccgccaa ccgcacggcc
     5161 aaccagaccg ccgagcccgg ccacaccgtc cactcctcca acctctgcac ggagatcctg
     5221 gaggtcacgg acgacggcga gacggccgtc tgcaacctcg ggtcggtgaa cctcggcgcg
     5281 ttcgtcgaca ccgagcgcgg cgacatcgac tgggagcggc tcgacgccac cgtgcgcacg
     5341 gccgtcacct tcctcgaccg cgtcgtggac atcaacttct acccgaccga gcaggccggg
     5401 cgctccaacg ccaagtggcg gcccgtgggc ctcggcgcga tgggcctcca ggacgtcttc
     5461 ttccagctga agctgccgtt cgactccccc gaggcacggg cgctctcgac ccgcatcgcc
     5521 gagcgcatca tgctcgcttc gtacgaggcg tccgcggacc tcgccgagcg caacggcccg
     5581 ctcccggcct gggagaagac ccgcaccgcg cgcggcgtcc tgcaccccga ccactacggt
     5641 gtggagctga cctggccgga gcgctgggcg gccctgcggg aacgcatcgc cgtcaccggc
     5701 atgcgcaact cgctgctcct cgccatcgcg ccgaccgcca ccatcgcgtc catcgcgggc
     5761 gtgtacgagt gcatcgagcc gcaggtctcc aacctgttca agcgcgagac cctgtccggc
     5821 gagttcctcc aggtcaactc ctacctggtg caggagctga agcggctcgg cgtgtgggac
     5881 gcgcagaccc gcgaggcact gcgcgagtcc aacggctcgg tgcagggctt cacctgggtc
     5941 ccccaggacg tccgcgacct gtaccgcacg gcctgggagc ttccgcagcg cggcctcatc
     6001 gacatggccg ccgaccgcac gccgttcctg gaccaggcgc agtccctgaa cctgttcctg
     6061 gagacgccga ccatcggcaa gctctcctcg atgtacgcct acgcctggca gcgcggcctg
     6121 aagaccacgt actacctgcg ttcgcgcccg gcgacgcgca tcgcccgcgc ggccggtggt
     6181 tcggccgccg ccgctgcccc cacccccgtc ccccagcagg tgagcgaccc cgacgcgatc
     6241 gcctgctccc tggaaaaccc cgagtcctgc gaggcatgcc agtaatcatg agtgacaaga
     6301 acctgctcga cccgggcttc gaactgaccc tgcggcccat gcgctacccg gacttctacg
     6361 agcgctaccg cgacgcgatc aagaacacct ggacggtgga ggaggtcgac ctccactcgg
     6421 acgtcgccga tctcgccaag ctcacccccg gcgagcagca catgatcggc cgcctggtcg
     6481 cgttcttcgc gaccggcgac tcgatcgtct ccaacaacct ggtgctcacg ctctacaagc
     6541 acatcaactc ccccgaggcg cggctctact tgagccgtca gctcttcgag gaggccgtgc
     6601 acgtccagtt ctacctgacg ctgctcgaca cctacctgcc cgacccggac gaccgcgcgg
     6661 cggcgttcga cgcggtcgag gagatcccct ccatccgcga gaaggcgcag ttctgcttca
     6721 agtggatcaa tgaggtcgag aagatcgagc gcctggagac gaaggccgac cgccgtcgct
     6781 tcctgctcaa cctgatctgc ttcgcggcgt gcatcgaggg gctgttcttc tacggcgcct
     6841 tcgcgtacgt ctactggttc cgctcgcgcg gcctgctgca cggcctggcg accggcacca
     6901 actgggtgtt ccgcgacgag accatgcaca tgaacttcgc gttcgaggtc gtggacaccg
     6961 tccgcaagga ggagccggac ctcttcgacg acgagctcaa ggagcaggtc acggacatgc
     7021 tgcgggaggc cgtcgacgcg gagctgcagt tcggccgcga cctgtgcggc gagggtctgc
     7081 cgggcatgaa caccgagtcg atgcgccagt acctggagtg cgtcgccgac cagcggctcg
     7141 tgcgtctcgg cttccccgcg ctgtacggct ccgagaaccc gttctcgttc atggagctgc
     7201 agggcgttca ggagctgacc aacttcttcg agcggcgccc gtcggcgtac caggtcgccg
     7261 tggagggctc ggtctccttc gacgacgagt tctgagtccg gtccggggcc ggagccgggt
     7321 tccggcccgg ctccgggacc tgcccgaggt ggggtccgtc cccgcgctcg gccgcgcgca
     7381 gctgccggtc gatccggcgg tcgtgggcgt gaccgatcag tgacggcagg gccatgagca
     7441 ggaagactcc gaggacggcc agcgtgttga gtgcgtcgtg tgcgttcatg acatccactc
     7501 tcgcgccggc cgtccttcgc cgtgagtggc aggactgccg cacaccctcg atttcctgcc
     7561 agcgctacgg cacactggca ggatgctgaa caacgtggcc gccgtcgtgc tcgacggcgt
     7621 gcatcccttc gaactcggcg tcgtgtgcga ggtgttcggc ctcgaccgca gcgacgaggg
     7681 gctgccggtg tacgacttcg cggtcgcctc cgccgagggc cccgtgctct ccacccacgc
     7741 cgggtacacg atcaccgccg cgcacggcct cgaccgcctc gaagaggccg acctcatcac
     7801 cgtcccggcc ggcgactcct acgtgaccag ggattttccg cccgacctgc tcgccgccct
     7861 gcgccgcgcc gccgaccgcg gcacccgggt gctcagcgtc tgcaccgggg tcttcgtgct
     7921 cgccgccgcc ggactgctcg acgggcggcg gtgcgccgtg cactggcggc acgccgagga
     7981 gctgaagcgg cgccatccgc gcgcgatcgt ggaaccggac gtgctgtacg tcgacgagga
     8041 cccggtgatc acctccgcgg gcaccgccgc gggcatcgac gcctgcctgc acctcgtccg
     8101 cagggagaac ggcacggagg tcgccaacgc catcgcccgc cggatgatcg tcccgccgca
     8161 ccgcgacggc ggccaggccc agtacatcga gcggccgctg ccccgcaccg cctgcgacac
     8221 cgtcggcggc gtgctcgcgt ggatggagcg ccatctcgac cgggagcaga ccgtcgacca
     8281 gctcgccgcc cgcgcccaca tgtcaccgcg gacgttcgcg cgccgcttcc agcaggagac
     8341 cggcaccacg ccctaccgct ggctgctgcg ccaacggctg ctgcgcgcgc aggagttgct
     8401 ggaggcgacg gacgagacgg tggacgcgat cgcgggccgc gccgggttcg ggaacgcggc
     8461 ggcgctgcgg catcagttcg tccgggcgct cggcacgacg cccaacgcgt accggcgtac
     8521 gttccgcggg cccgaggcgg actcggccgc ctgaccacgg gcccggggcc gacccggccg
     8581 cccgcgggcg ggggcgcgtc ggcctcggac cccgtgtcac ccggtcagcg ccgttcggcg
     8641 cgcaggacca gcttcttcgg gtgcagggtg atgccgacct tggtgccggt gtcggtcgcc
     8701 gcgaccggac tgaggcgcca cttcggcagg accgtggcca ggatgagggt gagttccgcc
     8761 agactgaagt gatcgcccgg gcacttacgg ttgccgacgc tgaacggcat catcgcgaac
     8821 tccggtacgc tcgcggcgcg ttccggattc catcggtccg ggtcgaactc cagatgccgg
     8881 tcgaacgaac gcggatcgcg ctgcatcgcg tacacgctgt agacgatgtc cgcgtcggcc
     8941 ggaatgcgat agccgccgag actggtctcg gccaccgagc ggcgcgtgaa aatccacgcg
     9001 gccgggcgta tacgcatcgc ctccgtgacg acattgcggg tgtgcggcag ctccttgaga
     9061 tcggcgaagg cgaccggacg tcccgacgtc acggaattta cctcttcaac caaccgcctt
     9121 tcctgctccg ggtgttcggt gagcagatgg aaggtccacg ccagcgtgga cgcgacattc
     9181 tccgcgcccg cgacgacgag cgagaccaca tggtcgtgga tctcctgatc ggcgatcggc
     9241 tccccggttt cgtcgcgcgc gcggagcaaa tcggccagca ggtcctgttc ctggccggtg
     9301 ccgagggcgc ggcgttcggc gatgatctcg tcgacgagcg cgtgcaggtc cgcgagcgcg
     9361 cgctcgaagc gccggttggc gggggtcggc acgcggtaga gcgggccgac ggagagcacc
     9421 atgcggcggt agagaccttc gaagacggtg tgcagcgagt cgctgatgcg gtccgccttc
     9481 tccccgatcg agtcgacctc caggagcgag cgggacacga tgcgtacggc ggtgcggaac
     9541 atctccgcac tgacgtccac cgtgccgccg tggccccagc gggccgccgt cgcctgtgcc
     9601 tcctcggcca tcacgcgcgc gtagtcggcg atgcgctcgg gccggaacgc gggctgcatc
     9661 atgcggcgct gacggcggtg cagcgggccg ttgctggtgg ccacgccctt gccgagcagg
     9721 acctccaggg tgtcccagag gggcccgccg acgatgtact ccgggctctt gagcatccgg
     9781 ccgaccagtt cgggatcgca caccgcgtac gcggtcttcg gccccagcct gatccggacg
     9841 agatccccat ggtcacgcag gtcggcgagg aagccgagcg ggtcgcgcac caggttccat
     9901 gcgtggccga gaaccggtgc cccgccctgg accaccggtg gggtgcggag ctgtgcggtg
     9961 ggcgtggtcg cgggtatcgc tgaggccgtg aattcaacgg tcattcttca ccaccagagg
    10021 gatcgatttc tgccaggtcg gtgctcggga attcgggggc tccggcgtcg gagacatacg
    10081 ggggaagggc cctgtcgtcc caactgtcga cgcgatacct gccggattcg tgatggaacc
    10141 agtacacgga actgaaccag ttccgcatgt tgaagacaca ggattgcagc gcggcgcccg
    10201 tgcgctttcc ctgcttgcca tcggccttca tctcgtcggc gaggagcagg agttccggct
    10261 ccaccgccaa gaaatcactg acgcagtcac gcacacgccg gtgcacttcc gccacggtct
    10321 cctgcaacga gagtccctcg tgctgcatga gggatattcc aaggttgtgc acctcgtcac
    10381 cggccagctc tttgggaagc gagcagaggt cgttgtacca ggcggagaaa tcctgggtcg
    10441 cgagcgccgc ggcgcgatag gccgggtgtt tacggacggc gtccggcaat tcgtaacgtg
    10501 cggtgggttc gaggagatcg atccacaccc agtgcgcgaa ggtgaggcgc cgcagttcca
    10561 cgtacgcctc gacgcccggg acggtcccgg tgcgccggtt gccgaactcg tggtcgtacg
    10621 cgtcgatcac cgggtggaag tgccgggcga accgcgcgtt ccagcgtggc ccgaggtgcg
    10681 agtagagcct caggacgcag tcagcgaagc ccgcgaccag tgggtccgga tggcccagtt
    10741 gccgccgggg gtgctccagt gtcgtgtgca gcccttggca cagccgccgc cactgcgccg
    10801 ttctgccgtg caccgcgtcg cggtcgtgcc ggtcgtccca gccgaagaac caggagctca
    10861 agtccgcgat ggcggcaagc agttcgtccg gggcgccgat gtagtacccg gcgaccaggt
    10921 cggtgtagca aaggctgtcg gcatatgccg cgaccttgtc cggggacatg agccgctttt
    10981 ccaggagcca tgcccgtgag ttctcctgaa gctttggcca atacggatgc agatgacggg
    11041 gaaactccga ctccaccacc ggaagggcca gtgggggcgg caccgatacc gcccgcgttc
    11101 gaacggccgg acgcatcggc ccggtcggct tgcgtcgctg ccgcgggacg cgttccgccg
    11161 catatgccgg aagccctgtc ggtacccgtg ccgtccggtc cgactgtgaa gtgctgcgtg
    11221 aggaagcagg cacgaacaaa cccctctcga ccgcctgagg acacacgccc ctcccgccgt
    11281 gccgggcgcg cgccgttgcg tatccccgcg ctttccattc agcaccacaa ctgaccgttc
    11341 agggaacaca tttgcgccat tcactacccc ggtgtgccga gaacatcccc ttacgtgact
    11401 gaatctggat caccggcggc cgatcatggg ctagtcctgt cctgttctgc acgggtacgc
    11461 caacggcccc tggtcagtgg ggtgttcccg accaggggcc gctgctgtca cgtacttccc
    11521 gtgcgcctca accggtgcac agttcagtcg ttcggcacca cggggtagcg cggagtgccc
    11581 tcttccatct gccggagcgc gtccttgcga tcccgcttgg agagccggtc gatgtacaga
    11641 tacccgtaca ggtggtccgt ctcgtgctgc aggcagcgcg cgaagtagcc cgttccgcgc
    11701 accttgatgg cgttgccctt ctcgtcctga ccggtcacga ccgcgtagtc cggccgggcc
    11761 aggtccgcgt acgccgtggg cacggacagg cagccctcgc ccgactcgtc caggtggcgc
    11821 tggtcggcgg gcagctcctg gagcacgggg ttgcacacga cgccgacgtg ccggacgccc
    11881 tcgtcgtcca tgcagtcgta gacgaagacc ttcaggtcca cgccgatctg gttggcggcc
    11941 aggcccacgc cctgcgcggt gcgctggctg gcgaacatgt cgtcgaccag ccgcgccagc
    12001 tcgtcgtcga aggcggtgac gtccttgcac tccttgtgca ggaccgggtt cccgacgacc
    12061 gtgatcggcc gcgaggtgcc gcgctcacgg aaggccgtct cgcgctcctc ggcgtcctcc
    12121 gtgtccacga cgaacccctc gtcgtcgacc ggaagcaccc ctccgcccgg ctgctgctgc
    12181 tcagtgtcct gcgccatgtc cgccgtatgc cttcttcctg gaaaccgctg cctgtcgtgc
    12241 ccgtacaggg tacggcgtcc gcaggcgccg gacgggctcg cgctgcttcc cccgccgggc
    12301 cggcagcggc ttcagggacg gccggggcgg aggggttcag cccgtcccgt ccgacgcctg
    12361 cggacgagcc gcgcggcggc gccgcgccgc ccgaagcccc ggggccaggg ccggtccgat
    12421 ggatcggccc tagcaaacct cttcgaggtc ccgccagtcc cgcgaatccg gactgtccgc
    12481 gacccacccg tcgagcaacc cccgcaccag ccccgcgggc gcagccagtc cgcactcccg
    12541 ctccggcacc cacagggccc ccgggctccg atgcccgagc ggccccggat gcccgggctc
    12601 gctgtggtcg tggggatcca ggtgctcccc gtccccctcg tcgctcggca tccgcgactc
    12661 cgaacacatc cggcacagca gccgcaccga ggacgaccag tcctccgcgg cgaacccggc
    12721 gtcggcggcg agccgctcca gcgcgtcccg gtcctcctcg gtggcggctt cgagcagcac
    12781 cacccacgtg ggcaccggcg agggcgccca cagctcgatc tcgtcgaaga cggggtacgc
    12841 gtgccccgcg gccgtggtcc gctcaccgtg cggcaccccg tcgtgcagga cgacctcgcc
    12901 ccagcgccgc ccggaggacg gcagcgggat ggagagcacc tctatccgcg ccgggtcgag
    12961 gcgacggccc cacacgacct ccgcctcgcc ctccggcgag agccgcacgg ccgcgctgcc
    13021 cagctccatg cccatgggtt cacccgtggc ggcgaccccg ccgggcacct tcaggccgta
    13081 cgcctgccag gcgcggcggg cgagcggcca gtcctggaga gcggtcgcgg cgatgccgac
    13141 gttccaccag tcgggggccc cggcggagcg gtcgagcagc gccacggccc tgaggcccgc
    13201 ggcccgcgcc tgctcccagt cgtgccggaa cttgtgcagc agcgcgaggt tgaaccagga
    13261 ctcggacagc cagggttcga gatcggcggc gcgtgtcagg agcgcgcccg cgtcctcgta
    13321 gcggccgtcg ccgatgagcg tgaacgcccg gtcggtggcc tgccgccagg aggcggaggg
    13381 ccggtgccgt cccttgccga agatcctcac gattcccgcc tgccagctct tgtcggggtt
    13441 tccccgctgc cgtgctgtcg cgctttcgcg cttccttcgc atccaaccac gtaccgtcgg
    13501 aaggccgctc attacccatg ggttacccag cggagcacgg ggtcagacgg cccgtggcgc
    13561 acgccaccac ggcgtcaccc gcgctccccc gcgggcccct ggggaagccc gtcgggggcc
    13621 tcctggggcg ggcccggcgg ctcggcggcc tgccgccgtt ccccgggccg cccccgcccc
    13681 cgcgcgagca cccgcgccag ggcctccacg acctccggct ggtagtcccg gccggtggcc
    13741 aggcgaagcc gctccagggc gctgagcggc ccctgcggcc cgtgttcccg agccatctcg
    13801 tcgtatgcgt tcgcggcgcg cacgatgcgc gcggtgagcg gctggtcgcg gtacggatcg
    13861 gcctggcgct ccacgaccac ggcgacgccg gcggcgacac ctgtctggcg tacgacggcg
    13921 ccgccgagca gggcgatgcg gcgctgctcg gcctcgggca gggcggcggt ggcaccggcg
    13981 gggacggggt cgacgaggga gagctggccg atgtcgtgca tcagggcggc gtgctccagg
    14041 acgcccaggt cggcgccgga gaggcccagc tcgcggccgg tggcgcggct gaggtcggcg
    14101 acgcggcggg cgtggccggg cggggtgtac ccggcgatct cggtggcgcg ggcgagggag
    14161 gcgatggtct gccggtaggt ggtccgggcg cccacgtacc ggcggaaggc cagctgggtg
    14221 aggagcagcg gcaggctgaa cacgggcagc gcccacagtc cggccacggc gacggccagc
    14281 gccatcacgg ccccggtcgc gcacacggcg gacccgatcc cggccatgcc ccgcagctcg
    14341 tcccgcagca gcggcccgaa cggccacccc gaccgggcgt gcgccagggc ggccgcgagc
    14401 acggcgtcgc acagcgcggt gagcgcgagc agtatcacga tgacggcggc gtacccgggc
    14461 ccgtgcccgg cgacggcctc caaccgcccg gagttgtaca gcggttggaa gcacagcgcg
    14521 gcgaacgcca cggcgagcac ccggcgggcg atgtggtcga gggacgggtc ccggccgagc
    14581 gccacctgcg gcacggcccc gaccaggccc gccgccacca cgacggcgac gacctgcagc
    14641 accccgtggt gcgtggcccg cccgccgcac tcccccaaca gggcgtacgc gagggccccc
    14701 gcggacccca gcggcgcggg ctcccgctcc gccccgctcc cccaccgcgc cagctccccc
    14761 accgctatga gcaccccgaa ccccaaggcg atccccggct ccgcgacccc gctccacagc
    14821 gtcgcgccca gcgcggcgac ggcgagaagg acggcggcgc cgcgcaccac gacgggcagc
    14881 cgcaccccgc tccgaggggt caccggcgga gggggcggta cgcctcgggg cggcgcgcgt
    14941 cgccgccggg cgcggacccg gacccgctca ccaccgcggc cggagccgcc ccggtcacgg
    15001 agccgccgcc cgggccggcc gccccgcgcc cctccgggcc gcccggctcc cgctcctcgg
    15061 caccgccccc ggcggtcacc tccgcgtccc acccgtgccg cgccagcgcc cgcaccagtg
    15121 cccccaccat ctccgcgtcg aactggaccc cggcgcagcg ctccagttcg gcgacggcgg
    15181 cggggacggg gcgggcgcgg cggtaggagc gggaggaggt catggcgtcg aaggcgtcgg
    15241 cgacggcgac gacgcgggcg gactcgggga tctgggtgcc ggtcaggccg taggggtagc
    15301 cgctgccgtc gatgcgttcg tggtggtgca ggatcgcggc gcgcgcgtcg ccgaggaagc
    15361 cgatgccgcg gaccatctcg tggccgtact cggggtgcag ttcgatcacc cggcgctcct
    15421 gcggggtcag cggtccgtcc ttgcgcaaca gccgcgtggg gacgccgagt ttgccgacgt
    15481 cgtgcaggat cccggcgaag cggaggacct ccacgcgcgc gtcgtccatg ccgagttcgc
    15541 gggcgatcag gacggcggcg cggccgaccc gttcgctgtg tccgcgggtg tagcggtcct
    15601 tgaggtcgac ggcctggacg agcgcgcgga tggtggcctg gtgggcggcg cgttcgcggt
    15661 ggtactgcgc gaacacccag caggagaccc ccatcggcag caggacgagg agggcggcgg
    15721 gcgggccgta ggggctctgc cagaggacgg ccatcatcag cccggcgagc ccgtgcacgg
    15781 cgacgggcgc gagcgagcgg ggcagcagtc cgcgccaggc ggtccgcgcg ggcacccgct
    15841 ccgccgtcac gaggatcccg ccgtcgagcg cggcgagcac cccggcgaag gcgagcacgg
    15901 cggccgcggc gggcagcagg acgtacggga agtcgggcgc cgaagcggcc gcgggcccgt
    15961 cgaacgcggc gtaggcctgc ccggcggccc aggcggccag ggcgagttgg gcggcgcgcc
    16021 aggcccggcg cagtcggcgc ggctgccgtt cgacgcgggc gcacagggcg ccggggacgg
    16081 cgacgagggc ggcggccgcg ggcggcagca ggaagacccc ggcgagcagg acggggaaga
    16141 acgtgcgggc ggcgacctcg tgccgcacgg cgcgctcgcc cccggcgtac agggcggcga
    16201 gcagcgcgac gacggtccag cgggtgccgg gaccgagggc gggcgccacg caggcggcgc
    16261 cgccgagggc gacgccgatg acgtagccgc gggcccgtgc cggaaccgag cgcatggccg
    16321 cctcctcccc gatccaggtc cggagatccg gagactagaa cggggttcgc gcacgccacg
    16381 gctcgcagcc gcgaattagc accttcgagt gagaaagcgc gtcagaaaga agagaaacga
    16441 acgaccggcg gccgaattcc accgcccgcg catctcggcg gatcgaaccg cccgaccgcc
    16501 gcagccgatc aagccgcccg gccgcctcag cggatcaggc cgtgccgcac gcgcagcgga
    16561 tcaggccgtg ccgtccaccg gcgtcgccgt caggtcctgg tcgggcaccg cctggcccga
    16621 gcggatcagg tcgatccggc ccatgacctt ggcccgcagg tcggcgggca cgtcgtcctg
    16681 gccgcagcag cgcttcacca gcttcttgac cgcctgctcg aggccgtact tctccaggca
    16741 cggagagcac tcctcgaagt gcgtctcgaa cttggtgcag tcactgtccg gcatctcgtg
    16801 gtccaggaac tcatagagat ggtccaggac ctcactgcag tcagtctcgt gcggctctcc
    16861 gcagctcatg agcctgagcc tttcgcttcg ttcgactccc cggcaccggc cgggaccaga
    16921 ccgcggtcgc gcgcgtagtc ctcgagcatg ccgcggagtt ggcggcggcc gcggtgaaga
    16981 cgggacatca ccgtaccgat gggtgtaccc atgatgtcgg cgatctcctt gtacgcaaag
    17041 ccctctacgt ccgcgagata gacggcgatg cggaattcct ccgggatcgc ctgcagcgcg
    17101 ttcttcacgt ccgagtccgg caagtggtcc agggcctgcg actcggccga gcgcagaccg
    17161 gtggacatgt gcgactcggc acgcgcgagc tgccagtcct cgatctcctc ggcggcgctg
    17221 cgctggggct cgcgctgctt cttgcggtac gagttgatga acgtgttcgt gaggatgcgg
    17281 tacaaccacg ccttgaggtt ggtgccctcg cggaactggt ggaacgacgc gtacgccttc
    17341 gcgtaggtct cctgcaccag gtcctccgcg tccgccgggt tgcgcgtcat gcgcagcgcc
    17401 gccgagtaca tctggtcgag gaacgtgagc gcgtcccgct cgaagcgggc cgtgcgctgc
    17461 gcggccgtct cctcgggctg ccccgactgc tcggcgtggc cgttctcggt ccctgcgtcg
    17521 gtcccagtga ccggacccac ctcctccaac gacgtggcgg gtccgaaagc ggccccactc
    17581 gaatcggagg atagacgacg accccctccg cgcgccgccc gaataggagc ggccttgggc
    17641 gcgctcagca ccgtccactc caggtcagag gcagtggagc ggttcgggca gatggtcgat
    17701 cccatgcggg ggctccctct cgtacgaaca cttgcggggt ctgctcgcca caacagtcgt
    17761 cacgggctca acattcccgc ccaccgggcg acggcgtccg tgatgcgttt cacggcctcg
    17821 tcctgcccga tgtccgcccg tttgggcacg gcgaaggagt gatcgccgaa ggggatctcg
    17881 acgagttcgt acgcggtgtc gtgcgcggtg gcctccggga actccgccgg tttgccgaag
    17941 gggtcgttgc ctccctggac gacgagggtc ggcaccccgg cgcccaggag ttcgtccgcg
    18001 cgggacttct ccggcttgcc cggcgggtgc agcgggaagc tgagcgcgag cacggcggcc
    18061 gcgccgagtc cggtggcggt acggcaggcc acgcgggccc cggcgctgcg gccgcccgcg
    18121 acgacgggca ggcccggctc ggccagcgcg ggccagacgc cgcgccagcc gacgtccagg
    18181 gtcttcggcg cgggcgccac cttcttgccc gcgacccgcc acggctgctc caccagggcg
    18241 acggtcacgc cgtgcgcggg cagggcggcg gcgatggccc gcaggtcccg cgcctcgatc
    18301 ccgccgcccg ccccgtggcc gacggcgagg acgagccgcg cccgcttcgc cgggtgccag
    18361 gtgatccggg ccgtacccgc gtcggtctcg acggtctcgg tggtctcggt ggtctctgcg
    18421 gtctcgctct tggccgcgtc tgcagcgccg gacgccttgc tccgggcggc gctggaagcc
    18481 ttgctcttgg tcacgtcaga agagtgtgcc ctcttccgga ccctccagct ccgtcagcag
    18541 ctccggcccg ttgttcttca cactgctcac ggccgtcgac accgggtagg cccgcatgag
    18601 gcccgccggg ggcggctcca ggagggagcg caggtcgtcc acgtccgtgc gggacgggtc
    18661 gagccaggcg tcccagcggt cgggggtcag catcagcggc atgcgcgggt ggatgtccgc
    18721 cagcgtcttg gggccttcct ggggggccac gcccagcggc gtcgtctccg cctccgtggt
    18781 gatcacggag caggtcaccc accacgccag cgggtgctcg tccggcagcg tcttgtcccg
    18841 ccagaactcg tacagacccg ccatcgcgaa caccgacccg tcggccgggg tcacgaagta
    18901 cggctgcttg cggggccgct tcttcttgcc ctcgacctcc agctcccgct cggcctcgcc
    18961 ggtcacccac tcgtaatagc cgtccgcggg cagcacgcac cggcgcgtgg tgaaggcccg
    19021 ccggtacgac ggcttctcgt gcacggtctc ggcgcgcgcg ttgatcatcc gcgccccgcc
    19081 ctccggcgtc ttcgcccagg acggtacgag tccccacttc agcttgcgga gctggcgaac
    19141 cggacggcgc tcctcggcgt ctttaagggg acggtcgagg acggcgtaga cctctttcgt
    19201 aggagccacg ttgtagtccg gctcaagagc ctcctccgga tcccacttct cgatctcaaa
    19261 gattcctgcg agatcctcgg gcctacgact cgacgcatac cgtccgcaca tgcgtgccac
    19321 actgccatgc ccgcccgtca cccgaccacc accccgcaac gaccgcgcta cgcgcgggca
    19381 cccgctgctc gccgacgaca gggagccaac ccggcaatgc acaccaccgc ttccgccagc
    19441 ctgggcgatc tctgggaccg gctcacgggc acgcaggccg cccccgagca gtggctggtg
    19501 ctcgtcaccg gggccgtcgc gctcgccgcc gtcctgccgc acgccgtctg gcgggtcgcc
    19561 cgcaacgccg tgaccatcgc ccacgagggc ggccacggtc tggtcgccct gctcaccggg
    19621 cgccgcctgg acggcatccg gctgcactcc gacaccagcg gcctgaccgt cagccgcggc
    19681 aggcccaccg gcctcggcat gatcctcacc gccgccgcgg gctacaccgc gcccccgctg
    19741 ctcggcctcg cgggcgccgc gctgctcggc gagggccgca tcacggcgct gctgtgggtc
    19801 gccacggccc tgctcgtcgc catgctggtg atgatccgca acgcctacgg cgcgctgacc
    19861 gtgatcgtct cgggcggcgt cttcctcgct gtgtcctggc tcgccgacac cgatgtgcag
    19921 gcggccttcg cgtacaccgt ggtgtggttc ctgctgctcg gcggcgtacg tcccgccttc
    19981 gagctgcagg ccaagcgcag gcacggcgga gccggggact ccgacgcgga ccagctgtcg
    20041 cggctcacgc acgttccggc ggggatgtgg ctgttcctgt tccacgccgt ttcgctgtgc
    20101 tcgctgatag ggggagcgcg ctggatgctc acggcgtgac gccggggctc ccgctcgtgg
    20161 cgtgacaggc gacggcccgt ggcgtgacgc cggcgggaca gctcgcggcc gccccgccgt
    20221 ggcccggtac tccccgtacg ccctacccgt tctctgtttc gcctgggttt cgccactttt
    20281 gatcaagatc tgcggtcggc gcgagacact aaagtgtggg catgaccgtg aacccgacac
    20341 acaccgccct ctggcccgcc ccgcacgcga gcggagccgt cgccgcgacg gtccacgtgc
    20401 cgggatccaa gtcggtcacc aaccgtgccc tcgtcctcgc cgcgctcgcc gccgagcccg
    20461 gctggctgcg ccgcccgctg cgctcgcgcg acaccctcct gatggcggcc gcgctgcgcg
    20521 cgatggacgt gggcatcgag gaaggcgtgg gccccgacgg ctccggtgag gcctggcgcg
    20581 tgatcccctc gggcctgcgc ggcccggcca cggtcgacgt cggcaacgcg ggcacggtca
    20641 tgcgcttcct gccgccggtc gccgcgctgg ccgacggccc gatccgcttc gacggcgacc
    20701 cccgttcgta cgagcgcccg ctgcacggcg tgatcgacgc gctgcgcgcg ctcggcgccc
    20761 gcatcgacga cgacggccgc ggcgcgctcc ccctgaccgt gcacggcgcc ggcgccgtgg
    20821 agggcggcca ggtcgagatc gacgcctcct cgtcgtccca gttcgtctcc gcgctgctgc
    20881 tctcgggtgc ccgcttcaac cagggcgtgg aggtgcgcca cgtcggcagc gccctgccct
    20941 ccatgccgca catccgcatg accgtcgaca tgctgcgcgc gtgcggcgcc caggtcgaca
    21001 cccccgaggc gggcggcgag ccgaacgtct ggcgggtcgc ccccggcgcc ctgctcggcc
    21061 gcgacctgac cgtcgaaccg gacctgtcca acgcccagcc gttcctggcc gcggcc
//
