LOCUS       NZ_BMVR01000001        10429 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000001
VERSION     NZ_BMVR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 923124)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 786301
            Orig. end                         :: 796730
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10429
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="5"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10429
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10429
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5429](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5429
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    1079..1094
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     gene            complement(1210..2676)
                     /locus_tag="IE274_RS03340"
                     /old_locus_tag="GCM10010349_06650"
     CDS             complement(1210..2676)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644283.1"
                     /locus_tag="IE274_RS03340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06650"
                     /product="MFS transporter"
                     /protein_id="WP_190113971.1"
                     /transl_table=11
                     /translation="MTTLDPSDTDVAQALSVETGSPEPQGGVLGKPHRALSIGIVSVVF
                     LIAFEATAVGTAMPVAARELDGIPLYAFAFSAYFTTSLFGMVLAGQWADRRGPLGALAG
                     GIGAFAAGLLLAGTAGAMWQFILGRAVQGLGGGLVIVALYVVVSRAYPEALRPSILAAF
                     AASWVIPSVIGPLIAGTVTEHAGWRWVFLGIPALVAVPLALALPAIRRTASGPVDPDAP
                     VEAFDRRRVRLALGISLGAALLQYAGQELRWLSLLPAVLGAAVLVPAVLGLLPRGTYRA
                     ARGLPSVVLLRGVAAGSFIAAESFVPLMLVTERGLSPTLAGLSLAAGGATWALGSYVQS
                     RPAMEAHREKLVVTGMVLVAAAIATAPSVLIDAVPVWTIAVAWAFGCLGMGMVIASTSV
                     LLLRLSAPEEAGSNSAALQISDGLSNALLLAAGGAAFAALGGGLTGGAHAAEATGSHPA
                     AFTAVFLPMAVVALAGAWLGTRLRSPRSVH"
     gene            complement(2792..3763)
                     /locus_tag="IE274_RS03345"
                     /old_locus_tag="GCM10010349_06660"
     CDS             complement(2792..3763)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS03345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_06660"
                     /product="hypothetical protein"
                     /protein_id="WP_190113972.1"
                     /transl_table=11
                     /translation="MTQPPGQQPGQPQSWQGGGFGPPPAAQGPYAPPRLRPYGAQQPSA
                     DNPYAQPGSQPNAQPGGQPNAQPYAEPGAQPYAHPNPQPPYGGYPPQFPTLGDGGPKPK
                     RWLAVTAAVAALAVIGGGVWFAVGKGDDGESKKPAAKAGGTADAEPRPSGTPSAEESDG
                     AGESDDPYADPDSGESEDEPGGGPTGTTLVGFWRSEKPGGGILGLRDSPDTTKPKKASV
                     SLLDDGRCTGLRRVIEAGRSYRIGLLCERDKKEIYGNLVFSGGDTLTVTWDQGRTGKET
                     YKRFLDWSEDGAGGGDAGSGGSGSGGSGTGGSGSGDPGSQGI"
     misc_feature    complement(3416..3418)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3875..4591)
                     /locus_tag="IE274_RS03350"
                     /old_locus_tag="GCM10010349_06670"
     CDS             complement(3875..4591)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS03350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_06670"
                     /product="hypothetical protein"
                     /protein_id="WP_190113973.1"
                     /transl_table=11
                     /translation="MTTTPPVPPTPPQPHAQYPQPPRPVSGHRGRTALVVVVVVLAVVA
                     AGLGAWWWTRDGDEGPLAGRPRVTDARAGVSYGIPGGWERNNKEGDLIGAFTSSIASKG
                     RGLGDSAEEGNKEERGGLALAGRSGAVPESALQSETERAARSNAEFFYPDGSSEVKESE
                     ATTVGGRPAHTVALAVRDGEGGTAHLRMTLVSLDGGRSAFLLGIATPGLGTGPNADRGP
                     LDEDTVDDVLASVALT"
     misc_feature    complement(4746..4761)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     misc_feature    4767..4782
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     misc_feature    4853..4869
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
     gene            5001..5429
                     /locus_tag="IE274_RS03355"
                     /old_locus_tag="GCM10010349_06680"
     CDS             5001..5429
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644282.1"
                     /locus_tag="IE274_RS03355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06680"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_190113974.1"
                     /sec_met_domain="melC (E-value: 3.7e-45, bitscore: 149.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGITRRRAIGAAASAAAGLAVVGATRAAATAAEPHAQAHPGAEP
                     DAFDEVYLGRRIQGGPSHGGGHHAAGHGGHGTGYSVRIDGDELHLMRNADGTWISVINH
                     YEPQASPRTLARAAVVELQGASLVPLAPPAPSSSPSAA"
     gene            5447..6274
                     /locus_tag="IE274_RS03360"
                     /old_locus_tag="GCM10010349_06690"
     CDS             5447..6274
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="IE274_RS03360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06690"
                     /product="tyrosinase family protein"
                     /protein_id="WP_190113975.1"
                     /transl_table=11
                     /translation="MTVRKNQSQLTADEKRRFIGALLALKRDGRYDSFVSTHNDFIMSD
                     TDNGDRVGHRSPSFLPWHRRFLIQFEQALQSVDPSVALPYWDWTTDRTPAASLWAPDFL
                     GGTGRSRDSQVTDGAFASSGSGWRINVRVDGRDFLRRSLGGGGRQLPTKAEVDSVLAMS
                     TYDMPPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGHMATGASPNDPVFWLHHAYVDKL
                     WTQWQSRHPNSPYLPASGTRDVVDLNDTMRPWGDVTPADMLDHTRYYTYDVAA"
     gene            complement(6256..6525)
                     /locus_tag="IE274_RS03365"
                     /old_locus_tag="GCM10010349_06700"
     CDS             complement(6256..6525)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541994.1"
                     /locus_tag="IE274_RS03365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06700"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_190113976.1"
                     /transl_table=11
                     /translation="MTLKPTARDARELNWFKSSYSSSNEPGDCVEVALEWTKSSYSSSG
                     DGNDCVEVASTPTTIHVRDSKNRQGPHLAFAAGAWRDFVQAATS"
     gene            complement(6522..7376)
                     /locus_tag="IE274_RS03370"
                     /old_locus_tag="GCM10010349_06710"
     CDS             complement(6522..7376)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527980.1"
                     /locus_tag="IE274_RS03370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06710"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190114134.1"
                     /transl_table=11
                     /translation="MSADGEGVDEAGWDVEPEDEIASVVEALGHQQKRWREAAGLTAGD
                     FGQAIGYGEDLVRKVERGARIPRPEYLDAADRVLGAGGFISAMKEEMTKARYPKKVREL
                     AKMEERAVELLLYCNHNLHGLLQTEEYMRALYDMRQPALTEDVVDREVEARLSRQSIYE
                     RSPAPAFGFVLEEAALRRPLGGETVWRRQLEHLLEVGRLRNVALQVMPTDREEHAGMGG
                     LIEVLKFEDGSAIGRSEGAFNSRPVSDPKQLRILELRYGMIRAQALTPPESLAFIEEVL
                     GET"
     gene            7536..7955
                     /locus_tag="IE274_RS03375"
                     /old_locus_tag="GCM10010349_06720"
     CDS             7536..7955
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327093.1"
                     /locus_tag="IE274_RS03375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06720"
                     /product="ATP-binding protein"
                     /protein_id="WP_190113977.1"
                     /transl_table=11
                     /translation="MDTETTQAPAAVRTFSIRLSSTPRGARLARRAAVGQLHAWGVPFE
                     PAQHIVAELASNAVRHGHVPGRDFRLTLRLTAGGVLRVEVTDTCTERLPRPPGPVAPDA
                     ESGRGLLLVEALATRWGTEVGPAPGKTVWAEVGDG"
     gene            complement(7966..8517)
                     /locus_tag="IE274_RS03380"
                     /old_locus_tag="GCM10010349_06730"
     CDS             complement(7966..8517)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562509.1"
                     /locus_tag="IE274_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06730"
                     /product="isochorismatase family protein"
                     /protein_id="WP_190113978.1"
                     /transl_table=11
                     /translation="MTTLPDRTRTAVLVIDMQNGVVAEAHERDAVIANIATVVDKARAA
                     DVPVIWVQHSDDELPRDSESWAYVPELVRRDGEPLVHKLYGDSFEATDLESVLAEHAVG
                     HLVVTGAQTDVCIRSTLHGALTRGYDATLVADAHTTEDLSGYGAPSPDLVIAHTNLYWH
                     RQEAPGRRGGTLRTQELSFS"
     tRNA            8685..8759
                     /anticodon=(pos:795019..795021,aa:Cys,seq:gca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IE274_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="GCM10010349_t00150"
                     /product="tRNA-Cys"
     gene            8685..8759
                     /locus_tag="IE274_RS03385"
                     /old_locus_tag="GCM10010349_t00150"
     gene            complement(8775..9719)
                     /locus_tag="IE274_RS03390"
                     /old_locus_tag="GCM10010349_06740"
     CDS             complement(8775..9719)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483197.1"
                     /locus_tag="IE274_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_06740"
                     /product="L,D-transpeptidase"
                     /protein_id="WP_190113979.1"
                     /transl_table=11
                     /translation="MARRTRIRHVVRGAAAAVLCAGVLAGCSVGGESGSAAPTEDDRKP
                     ASAGTPSPRAKPVVEPAALRRGGVRVNVADGQRVGVGMPVSVTFDRPVPKAERAAVERR
                     LKVRASTPTTGSWSWVKDRNLHEGQRVDYRPKAYWKPGTKVTVRVGSGIDRGFTVARSL
                     VATVDVRSHTMTVVKDGVTRRVPITAGAPGMDTWNGTMVVSDKQRRVFMDSRTVGYADA
                     YAGYYSYAVHLTTSGTYLHENPKANTYAGNSNVTHGCIGLATDGTARRFYEEVIPGDVI
                     RVTGSKETVAPGNGYGDWNVSWDEWRAGSALNA"
ORIGIN
        1 accggcgtcg tcggagagca cgagggtggc cttggtgccg gtgatctcgc ggatgagctt
       61 ggcgtaggcg cgggcggagt cctggtcgga ggcgatgacg aggccaccgg cgtccgggat
      121 ggccttgcgc acctcgccga ggcgccggtc ggcggccttc aggacgttcg gcatccagtc
      181 gccgcgcggg tcgagggcgg tgcgccaggc ctgcgagacg gcgtccttgg tcatgggctc
      241 gccgagccgg gcggcgatct cgtccccggc cttcgtgcgc caccgcatgt tgccgctgta
      301 cgacaggaag atcacgggcc gcacgacgcc gtcgccgagg gcgctgccgt agccgtacgt
      361 gtagtcggcg gaggaccgcc ggatgccgtc gttcccctcc tcgtacacga cgaaggggat
      421 ggggttggtg tcggaccgga agggcgtacc ggtgagggcg agccgccggg tggcgggctc
      481 gaaggcctca aggcacgcct cgccccagga cttgctgtcc ccggcgtggt ggatctcgtc
      541 caggatcacc agcgtcttgc gctgctccac ccggttccgg tgcagcatgg gccgcacgcc
      601 gacaccggcg tacgtgatcg cgacgccctg gtactccttg ctgagcggcc ccgcgctgta
      661 ctcgggatcc agcttgatcc ctatccgcgc ggccgcctcg gcccactgct tcttcagatg
      721 ctccgtgggc gcgaccacgg tcacctgctg caccacgtgg tggtgcagca gccaggacgc
      781 gagcgtcagc gcgaacgtcg tcttgccggc accgggcgtg gccacggcga ggaagtcgcg
      841 cggctgctcc tggaggtact tctccatcgc accctgctgc caggcgcgca gcttgctggc
      901 ggtgccccag ggggcgcggc ccgggaaggc gggggaaagg tggtgtgacg aggaggcggc
      961 ggtagtagtc acggtctccg gttcgttcgg gctcggcggc acggctacgt atgacaaccg
     1021 ggccacctta ccggtgcgac cccggggcac cgggttgacg accccgggga cggacaggtg
     1081 ggacacgtct cacacccgag taccgattca gcccgtccgg cgcttgagga cgaggcgcga
     1141 agcgccgata cgggggtccg ggggcggagc cccccggtta cgtgaagggg cgcccgcgcg
     1201 cgaagcgcgc taatggacac tgcgggggct gcgcagccgc gtccccagcc acgcccccgc
     1261 cagagcgacc accgccatcg gcaggaacac ggcggtgaac gcggccgggt gggaccccgt
     1321 cgcctcggcg gcgtgggcgc cgccggtcag cccgcccccg agggcggcga acgcggcacc
     1381 gcccgcagcg aggagcaggg cgttggacag gccgtcggat atctggaggg cggcggagtt
     1441 ggagcccgct tcctcgggcg ccgagaggcg cagcagcagg acgctggtcg aggcgatcac
     1501 catgcccatg ccgaggcagc cgaaggccca cgcgacggcg atggtccaca ccgggacggc
     1561 gtcgatgagg acgctgggcg cggtggcgat ggcggcggcc acgagcacca tcccggtgac
     1621 caccagcttc tcccggtgcg cctccatggc gggccgcgac tgaacgtacg agccgagcgc
     1681 ccaggtcgca ccgcccgccg ccagcgagag cccggcgagc gtcggcgaga ggccgcgctc
     1741 ggtgacgagc atcagcggta cgaaggactc ggcggcgatg aacgagcccg cggcgacgcc
     1801 gcgaaggagc acgacggacg gaaggccgcg cgccgcccgg taggtgccac gcggcagcag
     1861 cccgagcacg gcgggcacga ggacggcggc gccgagcacg gccgggagca gggacagcca
     1921 acgcagctcc tgccccgcgt actgcagcag cgcggcgccg agcgagatgc cgagtgcgag
     1981 gcggacgcgg cgccggtcga aggcctcgac gggggcgtcc gggtcgaccg gccccgacgc
     2041 cgtccgccga atcgcgggca gggcgagtgc gagcgggacg gcgacgaggg cggggatgcc
     2101 gaggaacacc cagcgccagc ccgcgtgttc ggtgaccgtg cccgcgatca gcgggccgat
     2161 caccgacggt atgacccagc tcgcggcgaa cgccgccagg atggacggcc gcagcgcctc
     2221 cgggtaggcc cggctgacca ccacgtacag cgccacgatg acgagcccgc caccgagccc
     2281 ctgcaccgcg cgccccagaa tgaactgcca catcgctccc gcggtgcccg cgagcagcag
     2341 ccccgccgcg aacgccccga tcccgcccgc cagcgctccc agcggcccgc gccggtcggc
     2401 ccactgcccc gccagcacca tcccgaacag gctcgtcgtg aagtacgccg agaacgcgaa
     2461 ggcgtacagc gggatcccgt cgagctcccg cgccgcgacg ggcatcgccg tcccgacggc
     2521 cgtcgcctcg aaggcgatga ggaagacgac ggacacgatg ccgatgctca gcgcgcggtg
     2581 gggtttgccg aggacaccgc cttgcggctc cggcgatccg gtctccacgg acagggcttg
     2641 ggcgacatcg gtgtcgctgg ggtcgagggt ggtcatgcga gccacggtaa gggccacgac
     2701 cgagtttgac ccctgtccgg aggaggccgc ccgctggtcc cttggtcgta cgacccgggg
     2761 ccggtgacgg gcgggcaccg actccgcgcg ctcagatccc ctgggacccc gggtcgccgg
     2821 aaccggaccc cccggtcccc gaccccccgg acccggagcc gccgctcccc gcgtcgcccc
     2881 cgcccgcgcc gtcctccgac cagtccagga accgcttgta cgtctccttc ccggtcctgc
     2941 cctggtccca ggtgacggtc agggtgtcgc cgccggagaa gacgaggttc ccgtagatct
     3001 ccttcttgtc gcgctcgcac agcagcccga tccggtacga gcggcccgcc tcgatcacgc
     3061 gccgcaggcc cgtgcagcgg ccgtcgtcga gcagcgacac cgacgccttc ttcggcttcg
     3121 tcgtgtccgg gctgtcccgc agcccgagga tcccgccgcc cggcttctcc gaccgccaga
     3181 acccgacgag ggtggtcccg gtgggcccgc cgccgggctc gtcctcgctc tccccggagt
     3241 cggggtcggc gtacgggtcg tcggactccc ccgcgccgtc cgactcctcc gcgctcggcg
     3301 tcccgctggg ccggggctcg gcgtcggcgg tcccgccggc cttggcggcg ggcttcttcg
     3361 actccccgtc gtcccccttg ccaaccgcga accagacccc gccgccgatg acggctaacg
     3421 cggccacggc ggcggtgacg gccagccacc gcttgggctt cggaccgccg tcgccgaggg
     3481 tggggaactg aggcgggtaa ccgccgtagg gcggttgggg gttggggtgg gcgtagggct
     3541 gggcgcccgg ctccgcgtag ggctgcgcgt tcggctgacc cccgggctgc gcattcggct
     3601 ggctccccgg ctgcgcgtac ggattgtcgg ccgacggctg ctgtgcgccg tacggccgca
     3661 gtcgtggcgg cgcgtagggc ccctgtgccg ccggaggcgg cccgaatccc ccgccctgcc
     3721 acgactgcgg ctggccgggc tgctgcccgg gcggctgcgt catctgtggt tcctcccccg
     3781 tcactccgac aacagactgt ccagccaagc ggccggtgta cgtacgttgc aagtgcaatt
     3841 tgagccagcc ggaacgcgcc tgcccgcgcc cggttcaggt cagcgccacg ctcgccagca
     3901 cgtcgtccac cgtgtcctcg tccagcggtc ccctgtccgc gttcggaccg gtgcccaacc
     3961 ccggcgtcgc gatccccagc aggaacgcgg accggccgcc gtccaacgag acgagcgtca
     4021 tccgcagatg ggcggtgccg ccctcgccgt cccgcaccgc gagcgcgacc gtgtgggcgg
     4081 ggcggccacc gaccgtggtc gcctcggact ccttgacctc cgacgatccg tccgggtaga
     4141 agaactccgc gttggagcgc gcggcccgct ccgtctcgct ctgcagcgcg gactcgggca
     4201 ccgcacccga ccgccccgcg agcgcgagac cgccgcgctc ctccttgttg ccttcctccg
     4261 ccgagtcccc gagccccctg cccttcgagg cgatcgacga cgtgaacgcg ccgatcaagt
     4321 ccccctcctt gttgttgcgt tcccaccccc cgggaatccc gtacgacact cccgcccggg
     4381 cgtccgtcac ccgcggcctg cccgcgagcg gcccctcgtc gccgtcccgc gtccaccacc
     4441 aggcgccgag gcccgcggcg accaccgcga ggaccacgac cacgacgacc agggcggtcc
     4501 tgccccggtg gccactgaca ggccgcggcg gctgcgggta ctgcgcgtgc ggctgcgggg
     4561 gcgtcggcgg aaccgggggc gtcgtagtca tgcgccaaga ctcgccgccc ggccccgccc
     4621 cctcctgagt acgcctactc aaggccctac tcactcgcac acatacacca cgcacaccag
     4681 tcccgtgcag ctctcggacg gcaagttttc cggccagctt tcccctgtga ccaggcgcac
     4741 ccgccgtgga gcagacgtga agatctttca cgctatcctc acgtaaggcg caggatttgc
     4801 ggtctgagca ccgccaggac gcatggacag cagaatcctg ctcgtccaac tctgcactat
     4861 ttacccgcag ttgtccgtaa taaggggcaa ctcttcccgc cgattacggc gccgcgcctt
     4921 cccccctgta cgcatggcct gggcagtccg gccgaccacc ggaaccgccc cttcaccacg
     4981 ctcacttggg ggttttacgc atgtccggaa tcacccgccg ccgggccatc ggcgccgcgg
     5041 cgagcgccgc cgccggtctc gccgtcgtcg gcgccacccg tgccgcggcg acggcggccg
     5101 agccgcacgc ccaggcccac ccgggcgccg agcccgacgc cttcgacgag gtgtacctcg
     5161 ggcgccgcat ccagggcggg ccgtcccacg gcggcggcca ccacgcagcc gggcacgggg
     5221 gccacggcac cggctactcc gtccgcatag acggcgacga actccacctc atgcgcaacg
     5281 ccgacggcac ctggatcagc gtcatcaacc actacgagcc gcaggcgtcc ccccgcaccc
     5341 tcgcccgcgc cgccgtggtc gagctccagg gcgcgagtct cgtcccgctc gccccgcccg
     5401 cgccctcgtc gtccccgtcc gccgcctgac ccggagcccc gccgccatga ccgtacgcaa
     5461 gaaccagtcc cagctcaccg ccgacgagaa gcggcgcttc atcggcgccc tgctcgccct
     5521 caagcgcgac gggcgctacg actccttcgt cagcacccac aacgacttca tcatgagcga
     5581 caccgacaac ggcgaccgcg tcggccaccg ttcgccgtcc ttcctgccct ggcaccgccg
     5641 cttcctcatc cagttcgagc aggcgctgca gtccgtggac ccgtccgtcg ccctgcccta
     5701 ctgggactgg accaccgacc gcaccccggc cgcctccctc tgggcccccg acttcctcgg
     5761 cggcaccggg cgcagccgcg acagccaggt caccgacggc gcgttcgcct cgtccggcag
     5821 cggctggcgc atcaacgtac gcgtggacgg ccgcgacttc ctgcgccgca gcctcggcgg
     5881 gggcggccgc cagctcccca ccaaggccga ggtcgactcc gtcctcgcca tgtccacgta
     5941 cgacatgccg ccgtggaaca gcgcctccga cggcttccgc aaccacctcg aaggctggcg
     6001 cggcgtcaac ctccacaacc gcgtccacgt ctgggtcggc ggccacatgg cgaccggcgc
     6061 ctcccccaac gacccggtct tctggctcca ccacgcgtac gtcgacaagc tgtggaccca
     6121 gtggcagtcc cgccacccga actcgcccta cctgcccgcc tccggtacgc gcgacgtggt
     6181 cgacctgaac gacacgatgc ggccgtgggg cgacgtcacg cccgccgaca tgctggatca
     6241 cacgcggtac tacacctacg acgtggccgc ctgaacgaag tcacgccagg cccccgccgc
     6301 gaacgcgagg tgggggcctt ggcggttttt ggagtcgcgt acgtggatgg tggtgggggt
     6361 ggaggcgact tcgacgcagt cgttgccgtc accgctgctg ctgtagctgc tcttggtcca
     6421 ctccagcgcg acctcgacgc agtcgccggg ttcattgctg ctgctgtagc tgctcttgaa
     6481 ccaattcagc tcgcgggcgt ccctggcagt gggcttgagg gtcatgtttc tcccagcact
     6541 tcctcgatga aggccagcga ctccggtggc gtcagagcct gggcccggat catgccgtac
     6601 cgcagctcaa ggatacggag ttgcttgggg tccgacacag gacggctgtt gaacgcaccc
     6661 tcggagcgtc cgatcgccga gccgtcctcg aacttcagca cttcgatcag gccgcccatc
     6721 ccggcgtgct cctcacggtc cgtaggcatc acctgaaggg ccacgttccg caaccgcccc
     6781 acctccagca gatgttcgag ctgtcggcgc cataccgttt cgccgccgag cgggcgtcgc
     6841 agcgccgcct cttccaggac gaagccgaac gccggggccg gtgaccgctc gtagatggac
     6901 tgtcggctga gtcgcgcttc cacctcacga tccaccacgt cctccgtgag cgcaggctgc
     6961 ctcatgtcgt agagagcccg catgtactcc tccgtctgca acaacccgtg caagttgtgg
     7021 ttgcagtaca ggagcagctc aaccgcccgc tcctccatct tcgccagctc ccggaccttc
     7081 ttcgggtacc gggccttggt catctcctcc ttcatcgccg agatgaaccc gcccgccccg
     7141 aggacgcggt cggccgcgtc caagtactcc gggcgcggga tacgcgcccc gcgctcgacc
     7201 ttgcggacaa ggtcctcccc gtacccgatc gcctggccga aatcccccgc ggtcagcccg
     7261 gccgcctcgc gccaccgctt ctgctggtgg cccagcgcct cgaccaccga ggcgatctcg
     7321 tcctcgggct cgacgtccca gcccgcctcg tccacacctt cgccgtccgc actcatcatg
     7381 cccacctccg aaaagcgccg ccccgctcca acgcgcagcc gtacccgtaa ggcactccgg
     7441 acagccggga cagcaccgga cagcgaccgg acagtcaccg tacgtgcacc gcgcatcacg
     7501 gtgcagggga agcggccggc gtcacgctga ggtgcatgga cacggagacc acgcaagccc
     7561 ccgccgccgt acggacgttc agcatccggc tctcctcgac gccgagaggc gcccgcctgg
     7621 cgcgcagagc ggcggtgggc caactccacg cgtggggtgt gccgttcgag cccgcgcagc
     7681 acatcgtggc ggagctggcg agcaacgcgg tgcggcacgg tcacgtaccg ggccgggact
     7741 tccgcctgac gctgcggctc acggcgggcg gggtgctgcg cgtcgaggtg acggacacgt
     7801 gcacggagcg gctgccccgc ccgccgggcc cggtggcccc ggacgccgag tcgggccggg
     7861 gcctgctcct ggtcgaggca ctcgccacgc gctggggcac cgaggtgggg cccgcgccgg
     7921 gcaagacggt gtgggcggag gtcggcgacg gctgaaccgt gcggctcagg agaaggagag
     7981 ctcctgcgtg cgcagggttc ccccgcgtcg gccgggcgct tcctggcggt gccagtagag
     8041 gttggtgtgc gcgatcacca ggtccgggga cggggcaccg tacccgctca ggtcctccgt
     8101 ggtgtgggcg tcggccacga gggtcgcgtc gtagccacgg gtgagggcgc cgtggagggt
     8161 ggagcggatg cagacgtcgg tctgggcgcc ggtgacgacg aggtggccga cggcgtgttc
     8221 ggcgaggacg gactccaggt cggtggcctc gaaggagtcg ccgtagagct tgtggacgag
     8281 gggctcgccg tcccggcgga ccagctcggg gacgtaggcc caactctcgc tgtcgcgcgg
     8341 gagttcgtcg tcggagtgct ggacccagat cacgggcacg tccgccgcgc gcgccttgtc
     8401 cacgacggtg gctatgttcg cgatgacggc gtcacgctcg tgcgcctcgg ccaccacacc
     8461 gttctgcatg tcgatgacca gcacggcggt acgggtgcgg tcgggcaggg ttgtcatggg
     8521 ggtctccagt tccacggtcc ccggtccacg gggtcgctgt cgcggcgttc cctgtttcgt
     8581 gaacgccgca tggcagtcgc gttgcggcgg cggcccggcg cttgaacggc gcgggccgtg
     8641 ccgcctacgg tcgatacgtc acgtacggcg agagcgtacg acgtggccgt gtgcccgagt
     8701 ggcttaggga ttcgcctgca aagcgaagca caccggttcg attccggtca cggcctccaa
     8761 gcccccgtaa gagatcacgc gttcagggcg ctgcccgctc gccactcgtc ccacgagacg
     8821 ttccagtcgc cgtagccgtt gccgggggcc accgtctcct tggagccggt cacgcggatg
     8881 acgtcgccgg ggatcacctc ttcgtagaag cggcgggccg tgccgtccgt ggcgaggcct
     8941 atgcagccgt gcgtgacgtt ggagttgccc gcgtacgtgt tggccttcgg gttctcgtgg
     9001 aggtacgtgc cggacgtggt gaggtggacc gcgtagctgt agtaaccggc gtacgcgtcc
     9061 gcgtagccga ccgtgcggga gtccatgaag acgcggcgct gcttgtcgga gaccaccatc
     9121 gtgccgttcc aggtgtccat gccgggcgcg cccgcggtga tcggcacgcg gcgcgtcacg
     9181 ccgtccttga ccacggtcat cgtgtggctg cgtacgtcga cggtggcgac cagggagcgg
     9241 gccaccgtga agccgcggtc gatgccggag cccacccgga cggtgacctt cgtgccgggc
     9301 ttccaatacg ccttggggcg gtagtcgacg cgctggccct cgtgcaggtt gcggtccttg
     9361 acccagctcc aggagcccgt cgtcggcgtg ctcgcgcgca ccttcaggcg ccgctccacc
     9421 gcggcccgtt cggccttcgg cacagggcgg tcgaaggtca cggacaccgg catgccgacg
     9481 cccacccgct gcccgtccgc cacgttcacc cgcaccccgc cccggcgcag cgccgcgggc
     9541 tccaccaccg gcttcgcccg gggcgagggc gtcccggccg aggcgggctt ccggtcgtcc
     9601 tccgtcggcg ccgccgaccc gctctcacca cccaccgagc agcccgcgag gacacccgcg
     9661 cagagcacgg cggccgccgc cccgcgtacg acgtgacgga ttctggtgcg cctggccatc
     9721 gggtccccct gtgtggtgtt ccggccgggg ccggtgtgtt tccatgtacg ccacccatac
     9781 gcacggcgga gaccgccggg ttgcatgggg cgtgcgggag aaattcgggg ctggttgcga
     9841 cggggcgcgg cgtgggcggc ggacggtcgc ggtcgtggac aggaacggcg ggggcatgac
     9901 ggaggacgag ttcgacgcgt tctacgcgtc cgcgttcccg cgcgtcgtcg gccaggtcta
     9961 cgccttcacc ggcgaccacg gacaggccca ggacgtcgtc caggaggcgt tcgtacgcgc
    10021 ctgggaccgg cggcgcgacc tcgcggccgt gcacgcgccc gaggcctggg tccgcacggt
    10081 ggccgtgcgg ctcgcggtga gccactggcg gcgggcccgg cgctggctgg agctggtccg
    10141 caaggagccg ccgcccgagc acacggcggg gcccggaccc gagcacgtga cgctcgtcgc
    10201 ggcactgcgg aagctgcccg aggcacagcg gctcgcgatc gtgctgcacc acctgtgtga
    10261 cctcagcgtg gagcaggtag cctccgagac cggcgccccc accggcacgg tcaaggcgcg
    10321 gctctcgcgc ggacgcgcgg cgctggccaa gcacctgtcc ggggacgacg gaggcgacgg
    10381 gggcgatggc gtcctcggcg ggacgagcaa cgggaaggag ggggatcgg
//
