LOCUS       NZ_BMVR01000001        22532 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000001
VERSION     NZ_BMVR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 923124)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 521225
            Orig. end                         :: 543757
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22532
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22532
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22532
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12532](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12532)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(968..983)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            complement(988..2637)
                     /locus_tag="IE274_RS02160"
                     /old_locus_tag="GCM10010349_04360"
     CDS             complement(988..2637)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016435092.1"
                     /locus_tag="IE274_RS02160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04360"
                     /product="dynamin family protein"
                     /protein_id="WP_190113788.1"
                     /transl_table=11
                     /translation="MVTLDVRPQLLDALSALRERVAAARFPLPLAGAPRARANRDELLA
                     QLDDYLVPRLRAPEAPLLAVVGGSTGAGKSTLVNSLVGRQVSEAGVLRPTTRTPVLVCH
                     PDDQHWFAGMRVLPHLTRAWAPRQGREGDDGAAPGPGGDSERLLRVLTADTLPCGLALL
                     DAPDIDSLVADNRVLAAELICAADVWVMVTTASRYADAVPWHLLRTAKEQDATLVTVLD
                     RVPHQVVGEVSRQYGALLAKAGLGDVPRFTVPELPESAGGGGLLPATAVEPLRTWLAHR
                     AQEPSSRRQAIERTAYGVLGSLNSRMPELAGAVAAQYAAALRLTSAVDEAYESEHARVR
                     ARLQAGAALAGDALKRWRAYPLDCGPGELLDAISESLEALLLCAVTAADEHIDDAWRRE
                     PAAQAPALVRRGGRYERAPYEDGDSPEHRIGMAVRRWRRELEEYAEDEVRTLDRADKNS
                     LPDADVVAALLATALLGGRRARTAGETLAERIGAHGALRLRDRGGRLLTDYLDKVLGAE
                     RERRLAPLDALDVNPEPQAELIAALSVLQKER"
     misc_feature    complement(2648..2664)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.17"
                     /tool="antismash"
     misc_feature    2648..2664
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.0"
                     /tool="antismash"
     tRNA            2963..3038
                     /anticodon=(pos:524221..524223,aa:Arg,seq:tct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IE274_RS02165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="GCM10010349_t00090"
                     /product="tRNA-Arg"
     gene            2963..3038
                     /locus_tag="IE274_RS02165"
                     /old_locus_tag="GCM10010349_t00090"
     gene            complement(3112..3906)
                     /locus_tag="IE274_RS02170"
                     /old_locus_tag="GCM10010349_04370"
     CDS             complement(3112..3906)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010351867.1"
                     /locus_tag="IE274_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04370"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_198898045.1"
                     /transl_table=11
                     /translation="MTSAHLPNDLGSRTRALPVAASASDLTKVLGDAAQRVTALADVSV
                     SFYQGQFTAIMGPSGSGKSTLMQCLAGLDSPTSGSVRVGGVELSGLSDRALTRLRRERI
                     GFIFQDFHLLPALTVAENITLPLSIAGRRPEPQWLEQIVTALGLMDRLSHRPPQLSGGQ
                     QQRVACARAMAGRPAIIFADEPTGNLDTRAGAEVLSLLGQLARELGQTIVMVTHDPAAA
                     ARTDRVVFLADGRIVDEVRRPDALQVLERMNRFDGTRHSDMP"
     gene            complement(3916..6081)
                     /locus_tag="IE274_RS02175"
                     /old_locus_tag="GCM10010349_04380"
     CDS             complement(3916..6081)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.5"
                     /locus_tag="IE274_RS02175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04380"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_190113789.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 7.8e-40, bitscore:
                     132.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDAAAVGSSEAPLDDSADPYRWLEEEGSPRTRSWLRLQQGLLER
                     HARHHEERTWGHILKEIDAAAVGRELSPRTEIGDSIFSHQLTADGGELIAVSEPDGRSR
                     VLLDTGDHAAHGRVARWLPDAAGNSVALQLHLDGHENGGLHIVPAAHGREAWYVPDASP
                     HPAVVFVGELLLYSSGSRTEHELRVRRLPGGTPRTVALPVPGPVRLSLHTGPGGHLLLR
                     TRAPASPAARWWCTRWDGSGTPDWQELPLAGLPVTAFAVGPNDMYIGGNGLLGLDLVSV
                     SRGCPVRLLPLVPLGPLVPPPSEGGSEGTIRALRVLDSGSADAAPSLAVLRQLGTTRRL
                     DVQRVIAAHGAVPDEPESDAVASGERGFGEPGSGAVASDAVATADEGNGEPAASGFTWH
                     ARLRIGPTARRADGGPGDGAWVLVDDPRFGAVSHRVTVGAPCVPRARRSVLRAAAATSG
                     DGATVPLTICDPPFVSAGQAAPTLITVYGGFGVSLEPSWDPIVAAWLAAGGRIAWVHAR
                     GGGELGPRWARAGRGPGKSGTVDDLCAAARYLQSGGEAGPGQLAALSASNGGMVVAAAM
                     VRASHLFAATVCVAPLTDMARYHIGGLGNLWHAEYGDPADRDALRALLGYSPYHRVRDG
                     TPYPATLFVTGGNDARVRPWHAWKLCAALQEATSSDAPVLLDHHEDGGHDGRSGSAARA
                     LNARFLALLAGRTGLRAPSTGNRSANR"
     gene            complement(6074..7309)
                     /locus_tag="IE274_RS02180"
                     /old_locus_tag="GCM10010349_04390"
     CDS             complement(6074..7309)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="IE274_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04390"
                     /product="MFS transporter"
                     /protein_id="WP_190113790.1"
                     /transl_table=11
                     /translation="MRPRLGGVFWLLFCGESASAVGTGASAIALPLVSFQDSGDVRAAG
                     LVSTALSVGIVAARLPAGLLADRHERRTILLWCNAVGALVLGALAVLQAAHAAQLAVLL
                     VAAFLLGTVGSTLAPAENVAVRNVVDAALLPRALALLQGRSAFAMIAGPLAGGALLKAD
                     AAWVFGADALTYLTAACCAFLLPSRTGPVSAEKTPLRATAEGLRFLWRSPLLRYGALNA
                     TVLNLVFNGLLIVIIASSQREGTGEVSVGVQTAALGAGALVGALAAAPVARHLPVRHAI
                     VGATAVIAAALTGFAVAQDTWGSALMLALAAAAGPVISVVVSAAQMRITPLSLQGRVHS
                     GSGFLAQAIAPLGPVLAGASSHAFGLTPTVFGAAGLVLLLAAVGAFITTHHARDPDNLP
                     HPEAPRLEAHRG"
     gene            complement(7306..9177)
                     /locus_tag="IE274_RS02185"
                     /old_locus_tag="GCM10010349_04400"
     CDS             complement(7306..9177)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.5"
                     /locus_tag="IE274_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04400"
                     /product="ABC transporter permease"
                     /protein_id="WP_190113791.1"
                     /transl_table=11
                     /translation="MYPGRVAGTALACAVTAAGVGASALLLIGASLPDYAEGSVEAAAA
                     QDAQDVLALLLSLLVMSAVLVVGSTVALWTGQRLHQFAVLRALGVTSGRLRRMVAGDVL
                     MLALVSAAVGAALGMVPLARLGRRLLVDRELFPETASLPSAGHVWSTGAGVCLITGAVA
                     VLAALASVLAAGRVSPGLLLKDPGSATATARSRARLVTGLLMILMLCVPLLCVMAFMDL
                     PVTVRAAMTPGLALTLIPSLAVLAPWIVPPLIRPVSAVLRIVDRRVGRVAAAGLSAAAS
                     RTTAMAVPVMLAVGVAVSLLGAGATIGKAVHHQAEDGLLADGVVTAEPGHRLPAAPRFP
                     GGSATALVHTEVTAAPTSLDDQPEPADTWGVDGPRLVRVLDLGVREGRMSALRGGTFAA
                     GAMQADSHHWRLGQRVRLTMADGSRQTLTLVAVYERDLAFPEYVVPRTTALKHTKAPYA
                     DKILLAGALRSWPADKGQKLETRAHYLDHLTPRNPADDLASRLIVSVISGYALLAAANT
                     CSLAQRDRRAQHAHLRALGLGRVQMLRCVLYESVGAATIGVGLAAITALACLIPLAMVL
                     DVGAAPALDLPWTAGVLVAAVLAVAVPSAMTAHPLHNVQEQFARRRA"
     CDS             complement(9392..9487)
                     /gene="allorf_530617_530712"
                     /locus_tag="allorf_530617_530712"
                     /protein_id="allorf_530617_530712"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MHMQNVLALQELDEETVIDAPISTLSGAACH"
     CDS_motif       complement(9425..9487)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MHMQNVLALQELDEETVIDAP"
                     /locus_tag="allorf_530617_530712_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9392..9424)
                     /prepeptide="core"
                     /locus_tag="allorf_530617_530712_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-3.00"
                     /molecular_weight="905.0"
                     /monoisotopic_mass="904.5"
                     /core_sequence="ISTLSGAACH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MHMQNVLALQELDEETVIDAP"
                     /leader_location="[9424:9487](-)"
                     /alternative_weights="923.0"
                     /alternative_weights="941.1"
     gene            complement(9536..9625)
                     /locus_tag="IE274_RS02190"
     CDS             complement(9536..9625)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="class III lanthipeptide"
                     /protein_id="WP_190113792.1"
                     /transl_table=11
                     /translation="MQNVLALQELDEETVIDAPISTFSAAGCH"
     CDS_motif       complement(9569..9625)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MQNVLALQELDEETVIDAP"
                     /locus_tag="IE274_RS02190_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9536..9568)
                     /prepeptide="core"
                     /locus_tag="IE274_RS02190_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-3.00"
                     /molecular_weight="939.0"
                     /monoisotopic_mass="938.4"
                     /core_sequence="ISTFSAAGCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQNVLALQELDEETVIDAP"
                     /leader_location="[9568:9625](-)"
                     /alternative_weights="957.1"
                     /alternative_weights="975.1"
     gene            complement(9670..9792)
                     /locus_tag="IE274_RS02195"
     CDS             complement(9670..9792)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="IE274_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_190113793.1"
                     /transl_table=11
                     /translation="MLEVLELQELDEETGVDALLSTLSLTGCHPVTTISVGSCH"
     CDS_motif       complement(9742..9792)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLEVLELQELDEETGVD"
                     /locus_tag="IE274_RS02195_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9670..9741)
                     /prepeptide="core"
                     /locus_tag="IE274_RS02195_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.10"
                     /molecular_weight="2153.5"
                     /monoisotopic_mass="2152.2"
                     /core_sequence="ALLSTLSLTGCHPVTTISVGSCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLEVLELQELDEETGVD"
                     /leader_location="[9741:9792](-)"
                     /alternative_weights="2171.5"
                     /alternative_weights="2189.5"
                     /alternative_weights="2207.6"
                     /alternative_weights="2225.6"
                     /alternative_weights="2243.6"
                     /alternative_weights="2261.6"
     gene            complement(9858..9947)
                     /locus_tag="IE274_RS40280"
     CDS             complement(9858..9947)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="IE274_RS40280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_190113794.1"
                     /transl_table=11
                     /translation="MLNVLALQELAAETGADALVSTISIGGCH"
     CDS_motif       complement(9897..9947)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLNVLALQELAAETGAD"
                     /locus_tag="IE274_RS40280_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9858..9896)
                     /prepeptide="core"
                     /locus_tag="IE274_RS40280_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-1.90"
                     /molecular_weight="1103.3"
                     /monoisotopic_mass="1102.6"
                     /core_sequence="ALVSTISIGGCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLNVLALQELAAETGAD"
                     /leader_location="[9896:9947](-)"
                     /alternative_weights="1121.3"
                     /alternative_weights="1139.3"
     gene            complement(10001..12532)
                     /gene="lanKC"
                     /locus_tag="IE274_RS02205"
                     /old_locus_tag="GCM10010349_04410"
     CDS             complement(10001..12532)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="IE274_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04410"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_190113795.1"
                     /sec_met_domain="micKC (E-value: 3.5e-197, bitscore: 652.6,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.8e-12, bitscore: 41.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 3.6e-07, bitscore: 25.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPRYEAYAIADATWYEPLERCKDSDSLFALGAAEPPRGWRREDH
                     GVWRFLAPDGGGELPEQGWKIHVSATPDGAAETIETAWEVCRRLALPWKFLRSRHIVTM
                     MNSKYANRATSGKAITVYPRTAEELHTALEELDTALGGGPGPYVLSDRRWNKGPVSVRY
                     GAFTLMWCELPDGSRVPALRDPQGRLVPDQRRPVFTVPDWADTPRFLAEGLASGESTDN
                     GGPLAAYRVEKALHFSNGGGVYQAQDAQGRQVVLKEARRYAGLDANGVDAVDRLRIEDD
                     MLKRLEQLPFVPRRFDSFTSWEHSFLVMEYVAGETVTSWLGREFPLTRHRPTEAARVEF
                     AALAVDRLEQVEACIEALHDAGVAFGDLHHRNILIRPDNTVALIDFELATPVDAVRKAA
                     LGAPGFTDTTITDPRDADLFALGCCQLAVLAPLTVLTLRNPAVVASLIDMATRSFPTVP
                     TDFVRRMIERLALSPALRPHLPSPGAATAAPLPVPDTADLLRGISRAADTGRTDRLFPG
                     DVHGHQPGASLGLAHGTPGVLLAQRAAGVRPAAEHVEWLVRTARQAPSDGPTGLYDGLA
                     GAAWLLHRLGHPEAPNLIDRLIDGPMPASPGLFGGSTGIAHLFLDVGLKEEALELALRV
                     RERIGTEGLLDRPGLMFGWSGPAVLFARCAESTGDLEWAQAAERAVRCDLRHARELDGM
                     LEMHSSDRLLPYLGEGSAGVALAALALPAAQADSLGVERVVDGAVRAGAVEVVIQGGLF
                     NGRAGLAYLLCHAVARAPQWREALDDHLRALALHLAPFKDAQVLHGDQLIRLSTDLATG
                     SAGAVLTQVAAQSPGSCLLPGAHPVCEVDLG"
     misc_feature    complement(12562..12573)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    complement(12584..12595)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    12746..12761
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.29"
                     /tool="antismash"
     misc_feature    12746..12764
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 26.11"
                     /tool="antismash"
     misc_feature    complement(12747..12763)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.6"
                     /tool="antismash"
     misc_feature    complement(12748..12762)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
     gene            12873..13529
                     /locus_tag="IE274_RS02210"
                     /old_locus_tag="GCM10010349_04420"
     CDS             12873..13529
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092230.1"
                     /locus_tag="IE274_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04420"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190113796.1"
                     /transl_table=11
                     /translation="MNGMKTRVLLADDQVSIRTGFRRILEAQHDLQVVGEAENGVTALA
                     ATRSLVPDVLLADIRMPEMNGLELTREVMQSTPSVHVVIVTTFDLDEYVHAALGAGACG
                     FLLKRSRSAVLIEAVRAAAAGDSMISPEITTRLLSRFRNRPLVVHQSSELLTKREQEVA
                     RLVAEGMTNADIGAELFISAGTVKTHLAHLQKKLKVQNRVGIAAWVWGSGLMEEP"
     gene            complement(13675..14736)
                     /locus_tag="IE274_RS02215"
                     /old_locus_tag="GCM10010349_04430"
     CDS             complement(13675..14736)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013209.5"
                     /locus_tag="IE274_RS02215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04430"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_190113797.1"
                     /transl_table=11
                     /translation="MNQIAADLSRLFVLPVCRLFIHCPQGSFAVYRIILSADDIMRIRV
                     SETNNPSVEAVFALQALHGSGHDGFGEWRLRVARNLMRSGARAQRTANLVRTVSDPEVL
                     LALCTGAGPSESRPRGDISASRAQAMSAIRDFFRLAVAPHWEPLRAHLSLAGDTRRDVM
                     SREGVRVLLDALGPDIRWNAPALEIHNVEAGELELNGTGLVLAPSIFLQSAGHVARFTG
                     GRGRDVPVLFFPDRPAADELARLLSDTTAAGERRGRESDGLAALLGRTRAAALRVLRER
                     EGWKNAELAERLGVSAAAVSQHTTVLRAAGLIATHRNRSHVVHTVTHLGRLLLQVGALE
                     SWPTASAPRPTFA"
     misc_feature    complement(14512..14514)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14733..15173)
                     /locus_tag="IE274_RS02220"
                     /old_locus_tag="GCM10010349_04440"
     CDS             complement(14733..15173)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS02220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_04440"
                     /product="hypothetical protein"
                     /protein_id="WP_190113798.1"
                     /transl_table=11
                     /translation="MSERTGAKIVLALALATLVALTGVSTGALDDLDASPRDGRRQFVF
                     DGTRLSVVVHGDGRARLRYGKKNEVTVTRKLTGAAAKKGNSSWSLEDQVLRLFARCTGI
                     AINCSVEYVVHLPPDVDVFVSASPGVTIMDLNGAQQTCDVEV"
     gene            complement(15237..16478)
                     /locus_tag="IE274_RS02225"
                     /old_locus_tag="GCM10010349_04450"
     CDS             complement(15237..16478)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="IE274_RS02225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04450"
                     /product="sensor histidine kinase"
                     /protein_id="WP_190113799.1"
                     /transl_table=11
                     /translation="MVTLIVATATTPSVGPLISGSGSVTVAAVLMLTAWRSRRSAVLLP
                     TMLIAAGTSLIVTFTYQGPARTAAANWWTAETLALMALVIFSVRRATVSTALGLSTLLA
                     TSIILSPLRITMNVVPRASGAETLQLCLLWAIFAMAAAGIGVYLRSLDTRSLARAAAER
                     RAERISLARDLHDYAAHDISAVVVLVEAAQVLAVEHPQQALELLPEIGAAGVQALQAMD
                     HTVQLLSEAPSGTERDGAAEVASGSVPPREAGGENGVPRPKRGPGARRDLSELPALVAR
                     FNRTGTPEAVLEVADGVLERLPADVSALGYRVVVEALTNVRRHAAAASRVEIVLSGDTW
                     RGDDALRIVVTDDAEHPQPVPGLVDRATGVGGTGISGLADRAAALGGELTAGPHPPHGW
                     SVSILVPLPGETPT"
     gene            complement(16632..17042)
                     /locus_tag="IE274_RS02230"
                     /old_locus_tag="GCM10010349_04460"
     CDS             complement(16632..17042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006376439.1"
                     /locus_tag="IE274_RS02230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04460"
                     /product="DUF3291 domain-containing protein"
                     /protein_id="WP_190113800.1"
                     /transl_table=11
                     /translation="MPIIPWVTPHKAAPDTIAFVMASRLEVKSLKHVPRFFWKSYATWK
                     QVRTAPGALGASLEAQLTKGVFYTLSAWQDRAALYAYARTEPHKSIMTGLRPTMRDSVF
                     TFWEVPAGELPIDWAEAKRRLAEEASTPHGHA"
     gene            17141..17824
                     /locus_tag="IE274_RS02235"
                     /old_locus_tag="GCM10010349_04470"
     CDS             17141..17824
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470066.1"
                     /locus_tag="IE274_RS02235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04470"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_190113801.1"
                     /transl_table=11
                     /translation="MRISELSRRSGVPTATIKFYLREGLMPPGRATSATQAEYDESHLR
                     RLRLVRALIGARGLSVSAAKEIVGSLSEVEGDTYELLGLVFGVWPGAGGGTDTGAGQGA
                     KADGDADSSANAGQDAEVDALIAELGWDVTEFSPARKTVTRTLNTLRGLGIAYDWRALL
                     PYARLAERTAALDLDQIEGPEDPLEKAERAVQLTFLLEPALLALRRLAQESEAAARYRG
                     PSDRP"
     gene            complement(17821..19749)
                     /locus_tag="IE274_RS02240"
                     /old_locus_tag="GCM10010349_04480"
     CDS             complement(17821..19749)
                     /NRPS_PKS="Domain: AMP-binding (55-507). E-value: 4.7e-94.
                     Score: 307.2. Matches aSDomain:
                     nrpspksdomains_IE274_RS02240_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976080.1"
                     /locus_tag="IE274_RS02240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_04480"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_190113802.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-88, bitscore:
                     291.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVRKDLKQARRRTDLADRAKVETVRDDQGVVREARTPALAASAT
                     RGSTADIPFTNAAEAPGAVVLRRKEADQWRPVTAAAFAREVTAAAKGLIASGLEPGGRV
                     ALMSRTRYEWAVLDFAIWAAGGQTVPVYPTSSAEQIEWIVRDSGATLLIAETGENAATA
                     RRAVAGHPTPPAVSVLDDGAVLELAERGHGVGDEEVTARRAALTPDSVATVCYTSGTTG
                     RPKGCVLTHGNLHAEAANTVALMHPVFKEVTGQTASTLLFLPLAHILGRSIQIACMLAR
                     IELGHFPSVRPDELRPELRAFRPTFVVGVPYLFERIHDTGRATAERMGRGASFDRADRI
                     AVRFAEAYLNKFQGRGRGPSLGLYAGWALYELLVYRRVRKEVGGRLRYAISGGSPLDKR
                     LNLFFYAAGILIYEGYGLTETTAAATIVPPLGPRAGTVGTPVPGTAIRIADDGEVLIKG
                     GIVFNAYWNNKEATDAVLADDWLATGDLGSLDDDGYLTITGRKKDIIVTSGGKNVSPAV
                     LEDRLRGRPLVGQCLVVGDNRPYVAAVITLDPEAVAHWLTVRKRPKDTPLSELCHDPQL
                     LEDLQKAVDYTNEAVSRAESIRRFVVVEGAFTEENGLLTPSLKLKRGAVVGAYAKEIEG
                     LYDSGGR"
     aSDomain        complement(18229..19584)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS02240_AMP-binding.1"
                     /evalue="4.70E-94"
                     /label="IE274_RS02240_AMP-binding.1"
                     /locus_tag="IE274_RS02240"
                     /protein_end="507"
                     /protein_start="55"
                     /score="307.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="NAAEAPGAVVLRRKEADQWRPVTAAAFAREVTAAAKGLIASGLEP
                     GGRVALMSRTRYEWAVLDFAIWAAGGQTVPVYPTSSAEQIEWIVRDSGATLLIAETGEN
                     AATARRAVAGHPTPPAVSVLDDGAVLELAERGHGVGDEEVTARRAALTPDSVATVCYTS
                     GTTGRPKGCVLTHGNLHAEAANTVALMHPVFKEVTGQTASTLLFLPLAHILGRSIQIAC
                     MLARIELGHFPSVRPDELRPELRAFRPTFVVGVPYLFERIHDTGRATAERMGRGASFDR
                     ADRIAVRFAEAYLNKFQGRGRGPSLGLYAGWALYELLVYRRVRKEVGGRLRYAISGGSP
                     LDKRLNLFFYAAGILIYEGYGLTETTAAATIVPPLGPRAGTVGTPVPGTAIRIADDGEV
                     LIKGGIVFNAYWNNKEATDAVLADDWLATGDLGSLDDDGYLTITGRKKDIIVT"
     CDS_motif       complement(18328..18396)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS02240_0002"
                     /evalue="1.10E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS02240"
                     /protein_end="474"
                     /protein_start="451"
                     /score="11.5"
                     /tool="antismash"
                     /translation="GEVLIKGGIVFNAYWNNKEATDA"
     CDS_motif       complement(19057..19116)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS02240_0001"
                     /evalue="4.10E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS02240"
                     /protein_end="231"
                     /protein_start="211"
                     /score="25.5"
                     /tool="antismash"
                     /translation="ATVCYTSGTTGRPKGCVLTH"
     gene            20252..22102
                     /locus_tag="IE274_RS02245"
                     /old_locus_tag="GCM10010349_04490"
     CDS             20252..22102
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS02245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_04490"
                     /product="hypothetical protein"
                     /protein_id="WP_190113803.1"
                     /transl_table=11
                     /translation="MTSTRTPVRRRGTLGALAALAGTAAARPGGRPGPARPLLRAALCL
                     APALVLLVAGFQRRWMSDDGHIYVRTVRQILAGNGPVFNAGERAESSTGTLWQWLLVLA
                     GLPGADVATAAVYGGLLLTAAGFGLAAWGAVRLHDGDGTRGGADGGRAGARGTRTLLPL
                     GALIPLALPPVWDFATSGLETGLATCWIGGAWLLLVTRPRSLATAFVLGLGPLVRPDLA
                     LVSAVFLGAQWLSARPSRRAALAGAGAAGALPVAYEIFRMGYYGHLVPLPGVTKEASQS
                     LWGRGLGYLGDFAGPYLLWVPALFVVAAVLPSGRTRLSARGEWSVRAGAAAPAAMSGPA
                     HPTVPLVPALAPVLAGLLCWAYVIKVGGDFMHARMFLPGLFLMVLPVFLVPATRAWALA
                     ATGVCGWAVVCAAVLRIGYEGHIGPGGIADERGVYVRQNAAAHPVHHTFGGYRENAAYA
                     REVRAAGHGGASALFVSRTRVDAAAPAVTGFYATLGLNGTVVPLDGAALDPIGLAYPLA
                     AHSQRIAHARVGHDKWLPDEWVVADRGTADLPSGLDPARVAAARRALGCGPLAELRAAT
                     RAPLTPGRFLRNAAGALERTSFRFPNDPVRAERELCGGGR"
ORIGIN
        1 acatgacctc ggcgtgcccc gcgagcggcc gcagatagcg ctcgtgcagc atcgcgtcgg
       61 cgtacttctc ggggtcgacg acccagatga ccgcgtcgac gagcccgagg atccggtcca
      121 cgtgctcgcg gtggtccccc gccgccgagt cgtggtcggg caggtcgacc agaacgagac
      181 cctggaggac ctgcgcgtcg gcccccggga gcggccgtct gcgcagcctt ccggggatgc
      241 cgagccggtc cagcagcccc gcggcgccgt ccgtccagct gcacccgatg ggcgcggcgg
      301 tggtgggtct gcgtacgccc gtctccgaaa tcatcacgcc cgccagggcg ttgaaaaggg
      361 tcgacttgcc actccccgtg gcacccgcga gcgcgacaac ggtgtgccgg tcggacagcc
      421 gtcgccgcgc ggcggcctcg tcgagcaccc gcccggcctc ggcgagcgtc ccggtgtcga
      481 gccgcgtacg ggacagcccg atcaactccc gcagcgcgtc gaggcggccg cgcagggccc
      541 cttcgtagac gacggttgtg tcctgcgtgg cggtgctgtt ctcgtacggg ggccgggtgt
      601 cgtacgcggc ggagtccccg tacgaggacg gcctctccgt agccgtggac acagccgacg
      661 gcgaaccgga cgcgaccgac ccggcaagga cctcggccac cgtcctgggg tccccgttcc
      721 ccggggacga gccgggcacg acgcgccgtg cgatgagccc gtcgtcccag acgccttcgg
      781 cctcgcgcgc gtggttgccg ttctcctcgc cgtccccggc ctgctgaaca ccccccgcat
      841 cgccgtccat gcccggcgcg ctggcgacac tctcagtgct ctccgcaccg ccggggccgc
      901 ctgccgtgcc gcctgtgcct tccgtgtcgt ctgtacgttc cagatcgccc gtgtgatcgg
      961 tgtggcccgt gacggcggtc accgcggtca cctctccttc tgcagtacgg acagcgcggc
     1021 gatgagttcg gcctggggct ccgggttgac gtcgagtgcg tcgagggggg ccaggcggcg
     1081 ctcccgctcc gcgccgagga ccttgtccag gtagtcggtg agcagtcggc cgccgcggtc
     1141 gcgcagccgc agcgccccgt gggcgccgat gcgctcggcg agggtctctc cggcggtgcg
     1201 tgcccgccgc ccgcctagca gggcggtggc gagcagcgcg gcgacgacgt cggcgtcggg
     1261 aagggagttc ttgtcggcgc ggtcgagggt gcggacctcg tcctcggcgt actcctcgag
     1321 ttcgcgccgc cagcgccgta cagccatgcc gatgcggtgt tcggggctgt cgccgtcttc
     1381 gtagggggct ctttcgtacc gtccgccgcg gcggacgagc gcgggggcct gggcggcggg
     1441 ctcgcgccgc cacgcgtcgt cgatgtgttc gtcggcggcg gtgaccgcgc acagcaggag
     1501 ggcttcgagg ctttcggaga tggcgtcgag gagctctccg gggccgcagt cgagcgggta
     1561 ggcgcgccag cgcttcaggg cgtctccggc gagcgcggcg cctgcctgga ggcgggcgcg
     1621 gacgcgcgcg tgctcgctct cgtaggcctc gtcgacggcg gaggtgaggc ggagggcggc
     1681 ggcgtactgg gcggcgacgg caccggcgag ttccggcatg cgggagttga gtgaaccgag
     1741 gactccgtag gcggtgcgtt cgatggcctg tctacgggag gagggttcct gggcgcggtg
     1801 ggcgagccag gtgcgcaggg gttcgacggc ggtggcgggg aggagtccgc caccgccggc
     1861 ggactcgggg agttcgggga cggtgaagcg cggtacgtcg ccgagtccgg ccttggcgag
     1921 gagggcgccg tactgccggg acacctcgcc gacgacctgg tggggcacgc ggtcgaggac
     1981 ggtgacgagg gtggcgtcct gttccttggc ggtacgcagg aggtgccagg ggacggcgtc
     2041 ggcgtaccgg gaggcggtgg tgaccatgac ccacacgtcc gcggcgcaga tcagctcggc
     2101 ggcgagcacg cggttgtcgg cgacgaggga gtcgatgtcg ggggcgtcga ggagggcgag
     2161 gccgcagggc agggtgtcgg cggtcagcac gcgcagcagg cgctcgctgt cgcccccggg
     2221 gcccggggcc gccccgtcgt caccctcacg gccctggcgg ggtgcccacg cgcgcgtgag
     2281 gtgcggcagg acgcgcatcc cggcgaacca gtgctggtcg tccggatggc acaccaggac
     2341 gggcgtgcgg gtcgtgggcc gcaggacgcc cgcctcgctc acctggcggc ccaccagaga
     2401 gttcacgagc gtggacttgc cggcgccggt ggagccgccg acaacggcca gcaacggcgc
     2461 ttcgggggcc cgtagccggg gcaccagata gtcgtcgagc tgtgcgagga gctcgtcccg
     2521 gttggcccgc gcgcgtggcg cccccgcgag ggggagcgga aagcgtgcgg cggcgacacg
     2581 ctcacgcagg gcggagagtg cgtcaagcag ttgaggccgt acgtccaagg tcaccacatg
     2641 cgaagaatgc ccaattttgg cgcctttctg aagcatatgg gcacccctgc gcgccgatcg
     2701 gacacccgcg acggaaggga cgactggggc gcaggcataa cgagtgcaca acacccgggg
     2761 cgacagacgc caaaagcgat gcgagattcg cacctgcctg cgattatcag gatcgcttca
     2821 ccgaacctcc acatcgcgtg gcggaggtga agcatcaggg acaagccacc aggagcccta
     2881 tccttgtccc cggtccatgg tccacgcccc ccggcaaggc cacggaccac ccaccgggct
     2941 ccaggccacc ggccgccacc cggcccccgt agctcagtgg atagagcagg tgccttctaa
     3001 gcacttggcc gcaggttcga gtcctgccgg gggcgccaca ctgaaggttc gcgcggcacg
     3061 cccgtggcgg ctaccgggcc gtcggcgacc agggcggaca aatcgactgt ttcagggcat
     3121 gtcgctgtgg cgtgttccgt cgaacctgtt catgcgttcc aggacctgga gggcgtccgg
     3181 ccgccggacc tcatcgacga tgcggccgtc cgcgaggaag acgacacggt ccgtgcgggc
     3241 ggctgccgcg gggtcgtgcg tcaccatgac gatcgtctgc cccagctccc gggccaactg
     3301 tccgagcagc gagagaactt ccgccccggc ccgggtgtcc aggtttcccg tcggctcatc
     3361 ggcgaagatg atggcggggc gccccgccat cgcccgcgcg caggccaccc gctgctgctg
     3421 accgccggac aactgcggcg ggcggtggga gagacggtcc atcagaccca gcgccgtgac
     3481 gatctgttcg agccactgcg gctccgggcg ccgcccggcg atgctcaaag ggagcgtgat
     3541 gttctcggcc accgtcagag cgggcaggag atggaaatcc tggaagatga acccgatccg
     3601 ctccctgcgc agtcgggtca gcgccctgtc ggagagtcct gacagctcga cgcctccgac
     3661 ccgcaccgac ccggaggtgg ggctgtcgag ccccgccaaa cactgcatca aggtggactt
     3721 ccccgaaccg gacggcccca tgatggccgt gaattgcccc tggtagaagg agacggagac
     3781 atcggccagg gcggtgactc gctgtgcggc gtcgccgagc accttggtga ggtccgaggc
     3841 ggatgccgcc acagggagtg cccgtgtccg agatcccagg tcgttgggca ggtgggctga
     3901 agtcacgtgg cactcctagc ggttcgcgga tcgattgccg gtggagggcg cgcgcaagcc
     3961 cgtccggccg gccagcagag cgaggaagcg ggcgttcaag gcccgggcgg cgcttccgga
     4021 ccgtccgtcg tgcccgccgt cctcgtgatg gtcgaggaga accggtgcgt cactggaggt
     4081 ggcctcctgc agcgccgcac acagcttcca ggcgtgccac gggcgcaccc gcgcgtcatt
     4141 gcccccggtc acgaagagcg tggcggggta gggcgtgccg tcacggactc ggtggtacgg
     4201 ggagtacccc agcagcgccc gcagcgcgtc ccggtccgcg ggatctccgt attcggcatg
     4261 ccagaggttg cccaggccgc cgatgtgata gcgcgccatg tccgtgagcg gggccacgca
     4321 gaccgtggcg gcgaagaggt gggaggcacg caccatggcc gccgccacga ccatcccccc
     4381 gttgctggcg gagagggcgg cgagctgtcc cggacccgcc tcgcctcccg actggaggta
     4441 ccgggcggcc gcacacaggt cgtcgacggt tccggacttt cctggaccgc gtccggcccg
     4501 ggcccagcgc ggcccgagct caccgccgcc acgggcatga acccaggcga tgcgaccgcc
     4561 cgcggccagc cacgccgcga cgatcggatc ccaggaaggt tcgagtgaga cgccgaagcc
     4621 gccgtagacg gtgatcaggg taggagccgc ctggcccgcg gacacgaacg gcgggtcgca
     4681 gatggtgagg gggacggtgg ccccgtcacc gctcgtggcg gcagccgcgc gcaggaccga
     4741 cctgcgtgcg cgtgggacgc acggcgcccc cacggtgact cgatggctga ccgcgccgaa
     4801 ccgagggtcg tccaccagga cccaggcccc gtcacccggt ccaccgtcgg cgcggcgagc
     4861 ggtcggtccg atccgaagtc gcgcgtgcca ggtgaacccg gatgcggccg gttccccgtt
     4921 tccttcatcc gcggtcgcca ccgcgtcgga cgccaccgca ccggatcccg gctcaccgaa
     4981 tccccgctca ccggatgcca ccgcatcgga ttccggctcg tcgggcaccg cgccatgcgc
     5041 tgcgatcaca cgctggacgt cgagccgccg cgtggtgccc aactgccgca gcaccgcgag
     5101 cgacggagcg gcgtcggcgc tgccggagtc gagtacgcga agtgcacgga tcgtcccttc
     5161 gctcccgccc tcggacggag gcgggacgag cgggccgagg ggaacgagag ggaggaggcg
     5221 caccgggcag ccccgggaca cagacaccag gtcgagcccg agcagcccgt tcccgccgat
     5281 gtacatgtcg ttcgggccga cggcgaacgc cgtgacaggg agaccggcca gcggcagctc
     5341 ctgccagtcc ggcgtgcccg agccgtccca ccgcgtgcac caccagcgcg cggccggaga
     5401 agcgggtgcc cgggtccgca ggagcaggtg gccgccagga cctgtgtgca gcgaaagccg
     5461 tacgggtccc ggaacgggca gcgcgacagt ccgaggagtc ccgccgggaa gtcgacggac
     5521 acgcagctcg tgctcggtgc gactcccgga gctgtacagc agcagctcgc cgacgaacac
     5581 gacggcgggg tggggggacg cgtcggggac gtaccacgcc tcgcggccgt gagcggcggg
     5641 gacgatgtgg aggccgccgt tctcgtgacc gtcgaggtgg agttgcagcg cgacggaatt
     5701 cccagcggcg tccgggagcc agcgggccac acgaccgtgc gcggcgtggt cgccggtgtc
     5761 gaggagtacg cggctgcggc catccggttc ggacactgcg atcaactcac cgccatcagc
     5821 ggtgagttga tggctgaaga tgctgtcgcc gatttccgta cgggggctca gctcacgccc
     5881 gacggcagcg gcatcgatct ctttgagtat gtgtccccag gtacgttcct catggtggcg
     5941 tgcatgtcgt tcgagcaggc cttgttgaag acggagccac gagcgcgtgc gcggggaacc
     6001 ctcctcctcc agccaacggt aggggtcggc gctgtcgtcc agcggcgctt cggaagagcc
     6061 gactgctgcg gcgtcatcca cgatgagcct ccaggcgggg tgcttcgggg tgcgggaggt
     6121 tgtcgggatc cctcgcgtgg tgggtggtga tgaaagcgcc gacggcggcg agaaggagca
     6181 ccagaccggc tgccccgaac accgtcggtg tcaggccgaa cgcatgggaa ctggccccgg
     6241 ccagtacggg gccgagcggc gcaatggcct gagcgaggaa gccgctgccg ctgtgaaccc
     6301 tgccctgcag actcagcggg gtgatgcgca tctgcgcggc ggagacgacc acagagatga
     6361 ccggtcccgc ggcggcggcg agcgcgagca tgagcgccga gccccaggtg tcctgtgcca
     6421 ccgcgaaacc cgtcagcgcg gcggcgatca cggcggtggc gccgacaatg gcgtgtcgta
     6481 cgggaaggtg tcgcgccacg ggggccgcgg cgagggcgcc gacgagagct cccgcgccga
     6541 gtgcggcggt ctgcacgccg acgctcactt cgccggtgcc ctcgcgctgg gaggaggcga
     6601 tgatgacgat caggagcccg ttgaagacga ggttgagcac ggtggcgttg agggcgccgt
     6661 agcgcaacag gggagatcgc cacaggaagc gcaggccttc ggcggtggct ctgagcggtg
     6721 tcttctccgc actgacgggg cccgttctcg aagggaggag gaaggcacag caggcggcag
     6781 tgaggtacgt gagggcatcg gcgccgaaca cccaggcggc gtcggccttg aggagcgcgc
     6841 cgcccgccag gggcccggcg atcatggcga aggccgaacg gccctggagc agggccagtg
     6901 ccctcggcag gagcgccgcg tcgacgacgt tgcgcacggc gacgttctcg gcgggagcca
     6961 gggtgctgcc gacggttccc aggaggaagg cggcgacgag gagcacggcc agctgcgccg
     7021 cgtgcgctgc ctgcaggacc gcgagcgcgc ccaggaccag cgcgcccacg gcgttgcacc
     7081 acagcaggat cgtcctgcgc tcgtgccggt cggcgagcag acccgccggc agcctggcgg
     7141 cgacgatgcc gacggacagg gcggtgctga cgagccctgc cgcccggacg tcaccgctgt
     7201 cctggaagga gaccagcggc agcgcgatcg ccgaggcgcc cgttcccacc gcggaggcgg
     7261 actcgccgca gaacagcagc cagaacactc ctcccaaccg cggtctcacg ccctcctcct
     7321 ggcgaactgc tcctggacgt tgtgcagggg atgggccgtc atggcggaag ggaccgcgac
     7381 ggccagcacc gcggcgacca gcacgccggc ggtccagggc aggtcgaggg ccggggccgc
     7441 accgacatcg agcaccatgg ccagcgggat caggcaggcc aacgcggtga tcgccgccag
     7501 gccgacaccg atcgtggcgg cgccgaccga ttcgtagagg acgcagcgca gcatctggac
     7561 gcggcccagt cccagtgcgc ggaggtgggc gtgctgggcg cgccggtcac gttgggcgag
     7621 cgaacacgta ttggcggcgg ccaacagcgc gtaccccgag atgacggaga cgatcaggcg
     7681 ggatgccagg tcgtccgccg ggttcctcgg ggtgaggtgg tcgagatagt gggcgcgcgt
     7741 ctccagcttc tggcccttgt cggcgggcca tgagcgcagg gcgcccgcga gcaggatctt
     7801 gtcggcgtag ggggccttgg tgtgcttgag cgccgtggtg cgcgggacca cgtactccgg
     7861 gaaggccagg tcgcgttcgt agacggccac cagggtcagc gtctgccgtg atccgtccgc
     7921 catggtcagc cggacgcgct gaccgagccg ccagtgatgc gagtcggcct gcatggcgcc
     7981 cgcggcgaag gttcccccgc gcagggcgga catccggcct tcgcgcaccc cgagatcgag
     8041 cacccgcacc agtcgtgggc cgtccacacc ccaggtatcg gcgggttccg gctggtcgtc
     8101 caacgaggtc ggcgcggcgg tcacttcggt gtgtacgagc gctgtcgcgg atccgccggg
     8161 aaagcggggg gcggcgggaa ggcggtgtcc cggctccgcg gtcaccacgc cgtcggcgag
     8221 cagcccgtcc tcggcctggt ggtgcacggc cttcccaatg gtggcaccgg cgccgagcaa
     8281 ggacacggcg accccgaccg ccagcatgac cggtaccgcc atggctgtcg tccgcgaggc
     8341 ggccgcgctg agtccggccg cggccacgcg cccgacgcgg cggtcgacga tccgcaggac
     8401 ggcggacacc ggacggatca ggggcggcac gatccaggga gcgagcacgg cgaggctggg
     8461 aatcagggtc agggcgagac caggggtcat cgcggcccgc acggtcaccg gcagatccat
     8521 gaaagccatg acgcacagca ggggaacgca cagcatcagg atcatgagga gaccggtcac
     8581 caggcgagcc cggctgcggg cggtcgccgt ggccgacccc gggtccttca ggagcagccc
     8641 ggggctgacg cgacccgccg cgagcacact ggccagcgcc gccaggaccg ccacggctcc
     8701 ggtgatcagg cagaccccgg ctcctgtcga ccagacgtgg ccggcggagg gcagcgaagc
     8761 cgtctcgggg aagagttcgc ggtccacgag gagccggcgt ccgagccggg cgaggggcac
     8821 catgcccagc gccgccccca cggcggcgga gacgagggcc agcatcagca cgtcaccggc
     8881 gaccatgcga cgcagccgcc cggacgtgac tccgagggca cgcaacacgg cgaactggtg
     8941 cagccgttgc cccgtccaga gcgcgacggt ggagccgacg accagcaccg cggacatcac
     9001 cagcaaggac aggagcaggg ccagcacgtc ctgggcgtcc tgagcggcgg cggcctcgac
     9061 cgagccctcc gcgtagtccg ggagactcgc gccgatgagc agcagtgcgc tcgcgcccac
     9121 cccggccgcg gtcacggcgc aggccagggc ggtgccggcg acccggccgg ggtacaccct
     9181 ggcttctgaa acgaatagac ggcgcatgct ggtcgagcca gcaagggaac gagaggtgcg
     9241 tgacgccgcg gacatcggct ttctgtcctc caccgggggc acatatgctg ggaggagtac
     9301 ggggggccac ccgaatcgtg gccccccgta ctcattggtg agaacgggac ggtcatgctc
     9361 ccgtttccaa cggggcggtc atgctcccgt ttcagtggca ggcggcgccg ctgagggtac
     9421 tgatcggagc gtcaatgacg gtctcctcgt cgagctcctg aagagccaga acgttctgca
     9481 tgtgcaatca cctcccttca tcgcacgtca ccgaccgaca acctccgctc atgcctcagt
     9541 ggcagccggc ggcgctgaag gtactgatcg gagcgtcaat gacggtctcc tcgtcgagct
     9601 cctgaagagc cagaacgttc tgcacgtgca atcacctccc ttcatcgatc gacggtccgc
     9661 acccgcgtct cagtggcagc tgcccacgct gatcgtggtc acggggtggc agccggtgag
     9721 gctgagggtg ctgagcaggg cgtcgacgcc tgtctcctcg tcaagctctt ggagctcaag
     9781 gacttcgagc atgcggagtg gccttccctc acgtcgcatt agggtcgatc gagcccggcc
     9841 gtggccagga ccaccgatca gtggcagcca ccgatgctga tggtgctgac cagcgcatcc
     9901 gcgccggtct ccgcagcaag ctcttggagc gcgagaacat tcagcacaag aagtcacctc
     9961 ctctcatggg tcggtacggc agggttccgg agtgtccgct tcaaccgagg tccacctcgc
    10021 agaccgggtg ggcgccgggg agcagacaac tgccggggct ttgggcggcc acctgtgtga
    10081 gcaccgcacc cgcggagccc gtggccagat ccgttgacag ccggatgagc tggtcgccgt
    10141 gcaggacctg ggcgtccttg aacggtgcca ggtgaagcgc gagggcgcga aggtgatcgt
    10201 ccagcgcttc ccgccactgg ggcgctcggg cgacggcgtg gcagagcaag taggcgagcc
    10261 cggctctgcc gttgaagagg ccgccctgga tgacgacttc gacagcgccg gcccggacgg
    10321 ccccgtcgac gacgcgttcg acgccgaggg aatcggcttg ggctgcgggc agcgccaggg
    10381 cggcgagcgc cacgccggcg gagccctcac cgaggtaggg cagcagccga tccgagctgt
    10441 gcatctccag catgccgtcc agttcccggg cgtggcgcag atcgcagcgc accgcacgct
    10501 cggcagcctg agcccactcc aggtccccgg tcgactcggc gcagcgggcg aacaggaccg
    10561 cggggccgga ccagccgaac atcagcccgg gtcggtccaa caggccttcc gtcccgatgc
    10621 gttcgcgtac ccgaagggcc agttcgagcg cttcctcctt gaggccgacg tccaggaaca
    10681 gatgggcgat gccggtgctc ccgccgaaca acccgggcga ggcgggcatg ggaccgtcga
    10741 ttaggcgatc gatgaggttc ggagcttccg ggtggccgag tcgatgcagg agccacgcgg
    10801 cgcccgcaag gccgtcgtag agtccggtcg gcccgtcgga gggagcctgc cgtgcggtgc
    10861 gtaccagcca ttcgacgtgc tcagcggctg gtctcacgcc cgctgcgcgc tgtgccagca
    10921 gcacaccagg agttccatgg gcgagcccga gggacgctcc tggctggtgt ccgtggacgt
    10981 ctccgggaaa cagccggtcc gtacgcccgg tatccgccgc acgagagatt ccgcgcagca
    11041 ggtccgcggt gtccggaacg ggcaaggggg cagccgtcgc ggccccggga gagggcaggt
    11101 gggggcggag cgccggggac agtgccaagc gctcgatcat ccgtcgcacg aaatccgtcg
    11161 gcaccgtcgg aaaggacctg gtcgccatgt cgatcaggga ggcgacgacg gctggattcc
    11221 gcagtgtcag cacggtgagc ggagcgagaa ccgcgagttg gcagcatccc agtgcgaaca
    11281 gatccgcatc gcgtgggtcg gtgatggtcg tatccgtgaa gcccggtgcg cccaacgcgg
    11341 ccttgcggac ggcgtccacg ggtgtcgcga gttcgaagtc gatgagcgcg acggtgttgt
    11401 cggggcggat caggatgttg cggtgatgca ggtctccgaa ggcgactccc gcgtcgtgca
    11461 gtgcctcgat acaggcttcg acctgttcca ggcggtcaac ggcgagtgcg gcgaattcca
    11521 cgcgggcagc ctctgtgggg cggtgccgcg taagggggaa ctcgcgcccc agccaggaag
    11581 tgacggtctc ccctgccacg tactccatga cgagaaagga gtgttcccag gaggtgaagg
    11641 agtcgaatcg ccgggggacg aaaggcagtt gctcaagcct cttgagcatg tcgtcctcga
    11701 tgcgcagccg gtcgaccgcg tcgactccgt tcgcgtcgag acccgcgtac cgccgggcct
    11761 ctttgagtac gacctgtcgg ccttgggcgt cctgagcctg atagacgcca ccgccattgg
    11821 agaagtgcag cgccttctcc acccggtacg ccgccaacgg gccaccgttg tcggtcgatt
    11881 cgccggacgc caacccctcg gccaggaaac gcggggtgtc ggcccagtcc ggcacggtga
    11941 agacggggcg gcgctgatca gggacgagcc gcccctgggg gtcacgcaac gccggcacgc
    12001 gggaaccgtc gggaagttcg caccacatca gcgtgaaggc cccgtaccgc acggacacag
    12061 gccccttgtt ccatcggcgg tcggacagca cgtaggggcc cggtccgccc cccagcgcgg
    12121 tgtccagttc ttcgagtgcg gtgtgcagct cctcggcggt ccgcgggtac accgttatcg
    12181 ccttgccact tgtggcccga ttcgcgtact tggagttcat catcgtgacg atgtgtctgc
    12241 tgcgcagaaa cttccaggga agcgccaggc gacggcacac ctcccaggcc gtctcgatgg
    12301 tttccgcggc gccgtccgga gtcgcactga catgtatctt ccagccctgc tccggcagtt
    12361 caccgccgcc atccggcgcg aggaaccgcc agactccgtg gtcttcccga cgccagcccc
    12421 gcggcggctc cgccgcaccc agggcgaaca gggagtctga atccttgcag cgctccaacg
    12481 gctcgtacca cgtggcgtct gcgattgcgt acgcctcata tctcggattc atgcactccc
    12541 ccaccgggcc aagagttcac agcgttcagt tcttcatgaa acagcgttca gttcttcatg
    12601 aatctgcgac gcgggcaggc gcgtcgggcc gaactcgaac ccaagagcca ggagccatcg
    12661 ctgcccgttg cacctaatct ttcagcgtgg cgctttacgg cagcaacctt cttaaggtca
    12721 cccttaatcg gaagatttcc ctccgattgc gagcgatttt cagcccgccg atcccatggc
    12781 agaaccctcc gcacaacggc cgccgcgctg gccgagattg ctcgatcgtg gcctgaattc
    12841 tccacctgca tgcgatcacc tcgcatggca ccatgaacgg catgaagacg cgcgtgctcc
    12901 tggcggacga ccaagtcagt atccggacag gttttcgcag gatcctggaa gctcagcacg
    12961 acctgcaggt cgtcggcgag gccgagaatg gggtgacggc cctggcggcc acccgttccc
    13021 tcgtacccga tgtgctgctc gcggatatcc gcatgccgga gatgaacggt cttgagctga
    13081 ctcgggaagt catgcaatcc acgccttccg tgcacgtggt gatcgtcacc acgttcgacc
    13141 tcgacgaata cgttcatgcc gcgttgggcg cgggagcctg cgggttcctc ctcaaacgtt
    13201 ccaggtccgc cgtgctcatc gaggcggtcc gggccgcggc ggcaggcgat tccatgatca
    13261 gccccgagat caccacccgg cttctgagcc gctttcggaa taggccgctc gtcgttcatc
    13321 aatccagtga gctcctgacc aagcgtgaac aggaagtcgc caggctggtg gcggaaggaa
    13381 tgaccaacgc cgatatcggt gccgaattgt tcatctccgc gggaacggtc aagacacacc
    13441 tcgcgcacct ccagaagaag ctgaaggtcc agaaccgcgt gggtatcgcc gcatgggtct
    13501 ggggctccgg actgatggaa gaaccgtagc tccgaccccc cgcgcacggc gcaatctgcc
    13561 gaacggccga tagcccggca ccgccgcttt cgacatcatg agcggtgtgc ggaggaattc
    13621 aggtgtgcgg aggaattcaa tggtctgcgt cgccaaggtg ctgcccccaa cacgtcatgc
    13681 gaaggtcggt cgcggtgcgg acgcggtcgg ccacgattca agtgccccca cttgcagcaa
    13741 aaggcggccg aggtgcgtga cggtatggac cacatggctg cgattgcgat gcgtggcgat
    13801 caggccggcg gcccgcagta cggtcgtgtg ctggctcacc gcggcggcgg acaccccgag
    13861 ccgttcggcg agttcggcgt tcttccagcc ttcgcgctct ctcagcacac ggagcgcggc
    13921 ggctctcgtt ctgccaagga gtgccgcgag gccgtccgat tccctgccgc gccgctcgcc
    13981 cgcagcggtg gtgtcactca gcaggcgcgc gagctcatcc gctgccggac ggtcgggaaa
    14041 gaacaggacc ggaacgtcac gccctctccc gccggtgaac cgggccacgt gcccggcgct
    14101 ctgcaagaaa atcgaaggtg ccaatacgag tccggtcccg ttcagttcca gctcgcccgc
    14161 ttcgacattg tggatctcca acgccggagc gttccagcgg atgtccgggc ccagggcatc
    14221 gagcagcacg cggaccccct cgcgggacat cacgtctctg cgcgtgtccc cggccaggct
    14281 caagtgggcg cgcaaaggct cccagtgcgg cgcgacagcc aggcggaaga agtcccgtat
    14341 cgccgacatc gcctgagccc gcgacgcgct gatgtcaccg cgcggcctgg attccgaggg
    14401 tcccgcgccg gtacacaacg caaggagtac ctccggatcg ctgacggtac ggaccaggtt
    14461 cgcagtacgt tgtgcccgcg cacccgagcg catcaagttc ctcgctacgc gtaaccgcca
    14521 ctcaccgaat ccatcatggc cactgccgtg gagcgcctgc agagcaaaga cggcctccac
    14581 ggacggattg tttgtctcgc ttaccctgat gcgcatgatg tcgtcagcag acagaatgat
    14641 tcgatacaca gcgaagctcc cctgagggca atgtataaac aatctacaaa caggcagcac
    14701 aaacagccga ctcaagtcgg cggcaatctg gttcacacct ccacatcgca cgtctgttgc
    14761 gcaccattca gatccatgat ggtgacacct ggcgacgccg agacgaacac atcgacatcc
    14821 gggggaaggt ggacaacgta ctcaacgctg caatttatcg cgatgccggt gcagcgcgcg
    14881 aagaggcgca ggacctgatc ctccaggctc caggatgaat tccccttctt tgccgccgca
    14941 ccggtcagct tccgggtaac ggtgacctcg ttcttcttcc cgtaccgcag ccttgcgcgg
    15001 ccgtcgccgt gcaccacgac ggaaaggcgc gttccgtcga agacgaactg gcgtcgtccg
    15061 tcacgagggc tggcgtccag gtcgtccagc gcacccgtgc tcaccccggt cagcgcgaca
    15121 agtgtcgcca gcgccaacgc cagaacgatc ttcgcccccg ttcgctcaga catgaggatc
    15181 atgctgccag gacggccctc atcccggtat cggccgtttg gcagatgcaa atcgggtcag
    15241 gtgggcgtct cgcctggcag gggcaccaag atgctcacgc tccacccgtg cggtgggtgc
    15301 gggcccgccg tcaactcgcc ccccagcgcc gctgcccggt cggcgagacc gctgataccg
    15361 gtgccgccca cacctgtcgc acggtccacc aggccgggca cgggctgcgg atgctcggcg
    15421 tcgtccgtga ccacgatgcg cagtgcgtcg tcgccgcgcc aggtgtcgcc gctgagcacg
    15481 atctccaccc gtgaggccgc ggcggcgtgg cgacgcacat tggtgagggc ctccacgacc
    15541 acgcggtatc ccagcgcgct cacgtccgcc ggcaggcgct ccagtactcc atcggccacc
    15601 tcaaggaccg cttcaggggt gccggtgcga ttgaaccggg cgaccagggc gggcagttca
    15661 ctgaggtcac gccgcgctcc cgggcctctc ttcgggcgcg gcaccccgtt ctccccgccc
    15721 gcctcgcgcg gaggcacgct gccgctcgcc acctccgcag cgccgtcccg ctccgtaccc
    15781 gacggggcct cggagagcag ctgaaccgtg tggtccatcg cttgcagggc ctgcaccccg
    15841 gcggcgccga tctcgggaag cagctccaac gcctgttggg ggtgctcgac ggccaggacc
    15901 tgggcggctt cgacaaggac gacgaccgcc gagatgtcgt gggcggcgta gtcgtgcaag
    15961 tcccgtgcca gactgatccg ttcggctcga cgctcggcag ccgccctggc gaggctgcgg
    16021 gtgtccaggc tgcgcagata gacgccgatg cctgcagcgg ccatcgcaaa gatggcccac
    16081 agcaagcaga gctgcagggt ctcggcaccg ctcgctcgag gaacgacgtt catggtgatg
    16141 cgcaggggcg acagaatgat cgaggtggcc agcagggtgc tgagccccaa ggccgtactc
    16201 accgtcgccc ggcggacgct gaagatcacc aacgccatca gcgccagcgt ctcggccgtc
    16261 caccagttcg ccgccgcggt cctggccgga ccctgatagg tgaaggtgac gatcagggat
    16321 gtccccgccg cgatcaacat ggtggggagc agcaccgccg accggcgtga tcgccatgcg
    16381 gtcagcatca gcacggctgc gaccgtcacc gagccggacc cgctgatgag cggcccgact
    16441 gacggagtcg tggcggtggc cacgatcagc gtcaccaccg ccgacagcgc gcagagaagt
    16501 tcgcgtaatc ccgtccgctt ccgtctcgtc acgcaacgaa agcgtagtgg tggccgggcg
    16561 ccgttagttc gtgtccctca gtcgccccag ggccacgcat gacgggcgcg acgtgggcag
    16621 ccttcgcccc gtcacgcgtg gccgtgcggc gtcgacgcct cctccgccaa gcggcgcttc
    16681 gcctccgccc agtcgatcgg cagctccccc gccgggacct cccagaacgt gaacaccgag
    16741 tcccgcatcg tcgggcgcag gcccgtcatg atgctcttgt ggggttccgt gcgggcgtac
    16801 gcgtacaggg cggcgcggtc ctgccaggcg gagagggtgt agaagacgcc cttggtgagc
    16861 tgggcctcca gggaggcacc cagggctccg ggggcggtgc ggacctgttt ccaggtcgcg
    16921 taggacttcc agaagaagcg cgggacgtgc ttcagggact tcacctccag gcgggaggcc
    16981 atcacgaacg cgatcgtgtc gggggccgcc ttgtgcgggg tcacccaggg aatgatcggc
    17041 acggtatcct cgatccctag ttagagagtg gcgctatcca tattaggtag tggcgctctc
    17101 taatgccata gggtcagtca cagggagagg gtcggcggct gtgcgtatct ccgagttgag
    17161 tcggcgcagc ggggtgccca ccgcgacgat caagttctat ctgcgtgagg ggctcatgcc
    17221 gcccgggcgg gccacctccg ccacgcaggc cgagtacgac gagtcgcatc tgcggcggct
    17281 gcggctcgtc cgggcgctga tcggcgcgcg cgggctgagt gtcagtgcgg ccaaggagat
    17341 cgtgggcagc ctgagtgagg tggagggcga tacgtacgag ttgctggggc tcgtcttcgg
    17401 ggtgtggccc ggggcgggcg gcggcacgga caccggcgcc gggcagggcg ccaaggccga
    17461 tggcgacgcc gactccagcg ctaacgccgg tcaggacgcc gaagtcgacg cgctcatcgc
    17521 cgaactcggc tgggacgtca ccgagttcag ccccgcccgc aagaccgtca cgcggaccct
    17581 gaacacgctg cgcggcctcg gcatcgcgta cgactggcgc gccctgctcc cctacgcccg
    17641 cctcgccgag cgcaccgccg ccctcgacct cgaccagatc gagggcccgg aggacccgct
    17701 ggagaaggcc gagcgcgccg tccagctcac cttcctcctg gaaccggccc tgctcgcgct
    17761 ccgccgcctc gcccaggagt cggaggcggc ggcgcgctac cgcggcccat cggacaggcc
    17821 ctagcgccca cccgagtcgt acagtccctc gatctccttc gcgtacgccc ccacgaccgc
    17881 cccgcgcttg agtttcaggg atggtgtgag gaggccgttc tcctcggtga acgcgccctc
    17941 gacgaccacg aagcggcgga tggactccgc gcgggacact gcctcgttgg tgtagtccac
    18001 cgccttctgc aggtcctcaa ggagctgtgg gtcgtggcac agctcggaca ggggggtgtc
    18061 cttggggcgc ttgcgcacgg tcagccagtg ggcgacggct tccggatcga gggtgatgac
    18121 ggcggctacg taggggcggt tgtctccgac gacgaggcac tggccgacga gggggcggcc
    18181 gcgcaggcgg tcctccagga cggcgggtga gacgttcttg cctccggagg tgacgatgat
    18241 gtccttcttg cggccggtga tggtgaggta gccgtcgtcg tcgagggagc cgaggtcccc
    18301 ggtcgccagc cagtcgtccg cgaggacggc gtcggtggct tctttgttgt tccagtaggc
    18361 gttgaagacg atgccgccct tgatgagcac ctcgccgtcg tccgcgatgc ggatcgccgt
    18421 gccgggtacg ggcgttccga ccgtacccgc gcgcgggccg agcggcggca cgatggtcgc
    18481 ggccgcggtg gtctccgtca ggccgtaccc ctcgtagatg aggattccgg cggcgtagaa
    18541 gaagaggttg aggcgtttgt cgagcgggga gccgccgctg atcgcgtacc gcaggcggcc
    18601 gccgacctcc ttgcggacgc ggcggtagac gaggagttcg tacagcgccc agccggcgta
    18661 gaggcccagg gacgggccgc ggccgcggcc ctggaacttg ttcaggtacg cctcggcgaa
    18721 gcgcacggcg atgcggtccg cgcggtcgaa ggaggcgccg cggcccatcc gttcggccgt
    18781 cgcgcgcccg gtgtcgtgga tccgctcgaa gaggtacggg acgccgacga cgaacgtcgg
    18841 tctgaaggcg cgcagttcgg ggcggagctc gtccggtctg acgctcggga agtggcccag
    18901 ttcgatgcgg gcgagcatgc aggcgatctg gatggagcgg cccaggatgt gggccagcgg
    18961 caggaacagg agggtcgacg cggtctggcc ggtgacctcc ttgaagaccg ggtgcatcaa
    19021 cgcgacggtg ttcgcggcct cggcgtgcag gttgccgtgc gtgaggacgc agcccttggg
    19081 tctgccggtg gtcccggagg tgtagcagac ggtggctacg gagtcggggg tgagggccgc
    19141 gcggcgcgcg gtgacctcct cgtcgcccac cccgtgcccg cgctccgcga gttcgaggac
    19201 cgcgccgtcg tcgaggaccg acacggccgg gggcgtgggg tgtccggcga ccgcgcggcg
    19261 cgccgtcgcc gcgttctccc cggtctcggc gatgaggagc gtggcgccgg agtcgcggac
    19321 gatccactcg atctgttcgg cggacgacgt cgggtagacg ggcacggtct ggccgcccgc
    19381 cgcccagatc gcgaagtcga ggaccgccca ctcgtagcgg gtacgggaca tcagggcgac
    19441 ccggccgccc ggttcgaggc cggacgcgat caggcccttg gcggccgcgg tgacctcgcg
    19501 ggcgaaggcg gcggccgtga cggggcgcca ctggtccgcc tccttgcggc gcaggacgac
    19561 ggcgccgggg gcctcggcgg cgttggtgaa ggggatgtcg gcggtgctgc cgcgggtggc
    19621 cgacgccgcc agggcggggg tgcgggcctc ccgtacgacg ccctggtcgt ccctgacggt
    19681 ctcgaccttg gctcggtcgg ccagatcggt gcggcggcgc gcctgtttca ggtccttgcg
    19741 tacgcccatg acggctcccg ttcgttcgct cggcgcgggt gcgggggtgc ggtgcatttg
    19801 cggtgcgggg tgtgggggat gcggtgcggg ggtgcggtgt ggtgcagggg gcgcggtgtg
    19861 gcgccggtgc ggcggatccc aacgcttact ttcgagtcaa cttaccgacg cgtaagggaa
    19921 tttcaatggt tcgcgcagaa gaactccggg ccgggcgcgg ggctcgaaac acaccgacca
    19981 caccgagagc atgctggtcc aggcccgcgc gcgggaacat ccaccccacg ctgaggacga
    20041 cgacgtccgg cggcccgacg gggacgtcgt cgcgcaccag cgcggcacgt accgcggcta
    20101 cgcgcgggag cagggcctcg gcctcctcaa gaggtgcgga ttccaggcgg agcacgggag
    20161 tgggaacggt ccgttccccg gctgtacgcg gctgcagccg gctggacagc caccgttcaa
    20221 gacccggctg acctgcgccg aagtacggtg catgacctct acacgcaccc ctgtccggcg
    20281 ccgcggcacg ctgggcgccc tcgccgccct cgccggcacg gccgccgcac ggccgggcgg
    20341 ccgacccggc cccgcccggc cgctcctgcg ggccgccctc tgcctggcgc ccgcgctcgt
    20401 gctcctcgtc gccgggttcc agcggcgctg gatgtccgac gacgggcaca tctacgtccg
    20461 cacggtccgg cagatcctcg ccgggaacgg accggtgttc aacgcgggcg agcgcgccga
    20521 gtcgtccacg gggacgctgt ggcagtggct gctggtgctc gcggggctgc cgggcgccga
    20581 tgtggccacc gccgccgtgt acggcgggct gctgctcacc gcggccgggt tcgggctcgc
    20641 ggcgtggggg gcggtgcggc tgcacgacgg ggacggcaca aggggcggcg cggatggcgg
    20701 ccgcgccggg gcccgcggca cccggacgct gctccccctc ggcgccctga tccccctggc
    20761 cctcccgccc gtctgggact tcgccacgtc cggtctggag accgggctcg ccacctgctg
    20821 gatcggcggc gcctggctgc tgctcgtcac ccggccgcgc tccctcgcca ccgccttcgt
    20881 cctcgggctc ggcccgctcg tacggcccga tctggccctg gtgtccgccg tgttcctggg
    20941 cgcgcagtgg ctgagcgcgc gcccctcccg gcgcgccgcg ctggccggtg cgggcgcggc
    21001 gggggcgctg ccggtcgcgt acgagatctt ccgcatgggc tactacgggc atctggtgcc
    21061 gctgcccggc gtcaccaagg aggcctcgca gagcctgtgg gggcgcggcc tgggctacct
    21121 cggcgacttc gccggaccgt atctgctgtg ggtgcccgcg ctgttcgtgg tggcggcggt
    21181 gctgccgtcg gggcgcaccc ggctgtccgc acgcggcgag tggtccgtgc gcgccggggc
    21241 ggccgcgccc gccgcgatgt ccgggcccgc ccacccgacc gtaccgctcg tcccggcact
    21301 cgcccccgtc ctcgcgggcc tgctctgctg ggcgtacgtc atcaaggtcg gcggtgactt
    21361 catgcacgcc cggatgttcc tgccgggact gttcctgatg gtcctgccgg tcttcctggt
    21421 gcccgccacg cgcgcgtggg cgctggccgc cacgggggtg tgcgggtggg ccgtggtgtg
    21481 cgccgccgtg ctgcggatcg ggtacgaggg gcacatcggg cccggcggca tcgcggacga
    21541 acgcggggtg tacgtacggc agaacgccgc cgcccacccc gtccaccaca ccttcggcgg
    21601 ctaccgcgag aacgcggcct acgcgcgcga ggtgcgcgcg gccgggcacg gcggcgcttc
    21661 cgccctgttc gtctcccgca cccgcgtcga cgccgccgcc cccgccgtga ccggcttcta
    21721 cgccaccctc ggcctcaacg gcaccgtcgt ccccctcgac ggcgccgccc tcgaccccat
    21781 cggcctcgcc taccccctgg ccgcccactc ccagcgcatc gcccacgcgc gcgtgggcca
    21841 cgacaagtgg ctgcccgacg agtgggtcgt cgccgaccgc ggcaccgccg acctgccgtc
    21901 cggactcgac ccggcccggg tggccgccgc ccgccgcgcc ctcggctgcg gcccgctcgc
    21961 cgaactgcgc gccgccacgc gcgcccccct cacaccgggg cgcttcctgc gcaacgccgc
    22021 cggcgccctg gagcggacgt cgttccgctt cccgaacgat ccggtgcggg cggaacggga
    22081 gttgtgcggc ggagggcgct gaggggggcg cgcggcactg cggggcgcgc ggcgctgcgg
    22141 cggcgggtac gaccgaagcc gcagtcgcct ccgtcagcgc ggcgtggacc cgccgtaccc
    22201 cggcgccggt gtccccgtgg cgtacggggc gggcggcgtc gtgtcctgcc gtgtgggcgc
    22261 ccgctcccgc aggtcgttcg ccttgcggat gctctccgcg agatcgcgca cgtcctcgtc
    22321 gtccgtcgtg tacgcgaggc cgcgcgccca ctgctcgagc cggtccggcg acggggcgcc
    22381 cggcagcggt gtcgtcgtgc tgtcctcgcc ctggctgccg tagtcctccc ggccgtcctc
    22441 gccgtatgtc tcgccgccgt cggggcggtc gtacggcgag cgcagcccgt cggcgaagta
    22501 cgcggcggtg gcggccactt ggaagcgcgg gt
//
