LOCUS       NZ_BMVR01000001        22826 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000001
VERSION     NZ_BMVR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 923124)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 45059
            Orig. end                         :: 67885
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22826
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22826
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22826
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12826](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12826)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            467..760
                     /locus_tag="IE274_RS00185"
                     /old_locus_tag="GCM10010349_00360"
     CDS             467..760
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048443.1"
                     /locus_tag="IE274_RS00185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00360"
                     /product="hypothetical protein"
                     /protein_id="WP_190113467.1"
                     /transl_table=11
                     /translation="MSPVHKQRTTEAAKVVVVIADVMAFILALWVLMDLLDANRANDLV
                     QVVHDSARWLASWSHDLFTFDERWARVVAGYGLAAVVYLVAGHFLAGRLRRH"
     gene            complement(804..1877)
                     /locus_tag="IE274_RS00190"
                     /old_locus_tag="GCM10010349_00370"
     CDS             complement(804..1877)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641460.1"
                     /locus_tag="IE274_RS00190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00370"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_190113468.1"
                     /transl_table=11
                     /translation="MTIPERTEHLVLPGVLTADQATATVRGILAVQRADGAIPWFRGHH
                     LDPWDHTEAAMALDAAGEHAAAARAYEWLARHQNPDGSWYAAYADGDPDDVTDRGRETN
                     FCAYVAVGVWHHYLSTGDEAFLDRMWPVVVAAVEFVLALQQPGGQIGWKRDPDGTPVPD
                     ALLTGCSSVYQALRCALALADLRDDPQPDWELATGALGHAIRHHPERFLDKDRYSMDWY
                     YPVLGGAVTGPEAKSRIEEGWDRFVVPGLGVRCVHPNPWVTGGESAELALALWALGESD
                     RALDILKSIQHLRDPESGLYWTGYVFEDAAIWPVELTTWTAGSLLLAVAALGGDEATCG
                     VFSGAGLPVGLEPDCCG"
     gene            complement(1874..2647)
                     /locus_tag="IE274_RS00195"
                     /old_locus_tag="GCM10010349_00380"
     CDS             complement(1874..2647)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641459.1"
                     /locus_tag="IE274_RS00195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00380"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_190113469.1"
                     /transl_table=11
                     /translation="MLTVDFTRFPLAAGDRVLDLGCGAGRHAFECYRRGARVVALDQNA
                     DEIREVAKWFAAMKEAGEAPAGATATAMEGDALNLPFPDESFDVVIISEVMEHIPDDKG
                     VLAEMVRVLKPGGRIAVTVPRYGPEKVCWALSDAYHEVEGGHIRIYKADELLARMRESG
                     LKPYGTHHAHALHSPYWWLKCAFGVGKDGKDAALPVRAYHKLLVWDIMKKPRATRVAEQ
                     LLNPVVGKSFVAYATKPHLPRTATTDPAADTKAGA"
     gene            complement(2641..4140)
                     /locus_tag="IE274_RS00200"
                     /old_locus_tag="GCM10010349_00390"
     CDS             complement(2641..4140)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672414.1"
                     /locus_tag="IE274_RS00200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00390"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_229909054.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.3e-31,
                     bitscore: 104.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEAMEAGPLPGPVPGATPGTTPDVPPGTAADGGRRLRIALLTY
                     KGNPFCGGQGVYVRHLSRELVRLGHRVEVIGAQPYPVLDEGEDLRGLSLTELPSLDLYR
                     SPDPFRTPKRDEYRDWIDALEVGTMWTGGFPEPVTFSLRARRHLRARRGEFDVVHDNQT
                     LGYGLLGDLGAPLVTTVHHPITVDRRLELDAAPDWKRRASVRRWYAFTRMQKRVARRLP
                     SILTVSGTSRQEIVDHLGVRRDRVNVVHIGADTTLFSPDPAVPEVPGRIVTTSSADVPL
                     KGLIHLVEALAKVRTENPAAHLVVVGKRAEDGPVAQAIEKYGLQGAVEFVKGITDEELV
                     DLVRSAQIACVPSLYEGFSLPAAEAMATGTPLLATTGGAIPEVAGRDGDTCLAVPPGDA
                     GALAAGLTRLLGDPALRARLGAAGRARVLDRFTWARAAQGTAELYREAIDRSASRGAAR
                     AVARGQALPTAGATGAPALPTAATAVSGEVAGPQPESRATC"
     misc_feature    complement(4185..4201)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.82"
                     /tool="antismash"
     misc_feature    4194..4207
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     misc_feature    4200..4214
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.58"
                     /tool="antismash"
     gene            4430..5068
                     /locus_tag="IE274_RS00205"
                     /old_locus_tag="GCM10010349_00400"
     CDS             4430..5068
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641457.1"
                     /locus_tag="IE274_RS00205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00400"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_190113470.1"
                     /transl_table=11
                     /translation="MTADAKTAAGAGAAHPASPPLTERQEARRRRILHASAQLASRGGF
                     DAVQMREVAESSSVALGTLYRYFPSKVHLLVATMQDQLQHMHTTLRKHPPAGRTPAERV
                     AETLMRAFRALQREPHLADAMVRALTFADRSVSPEVDTVSRLTTAIVLDAMGLDGQPTA
                     AQLSAVRVIEHTWHSALITWLSGRASIAQVKIDIEMVCRLIDLTVPESA"
     gene            5515..6126
                     /locus_tag="IE274_RS00210"
                     /old_locus_tag="GCM10010349_00410"
     CDS             5515..6126
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386627.1"
                     /locus_tag="IE274_RS00210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00410"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190113471.1"
                     /transl_table=11
                     /translation="MIRVLLVHDACLLRSALAERLAREPDLEVFHTPWGAARRRLGSVR
                     PDLCVADLDCETGYALAPLGELKTTATGTGTRCPLLVLASAHRPGLLRRALDAGAVGFV
                     DKASVPEQLLTAIRQVAAGVRYVDDSLGFGFLKAAQMPLTQRELSVLTLAAGGASVAEI
                     AHRLHLSNGTVRNYMAAITRKTGARNKVDAIRISLGEGWV"
     misc_feature    6106..6108
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6127..7986)
                     /locus_tag="IE274_RS00215"
                     /old_locus_tag="GCM10010349_00420"
     CDS             complement(6127..7986)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827682.1"
                     /locus_tag="IE274_RS00215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00420"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_229909057.1"
                     /transl_table=11
                     /translation="MSRKGGSGAASGGGTGTYARGARFLRERRWVVAQIAFWSVLETGQ
                     TFLTGYALAHALDDGFLAGDGAVGLGWLLAAAGGVLVAAYGTGQVFRAVARLVEPMRDV
                     LVRHVVARGIEEADSAAVSRLTQQVETARDTFAGLVMVSRSFVFTAVGALIGLCTLAPL
                     LVLVVAPPLVAGVGLFVLTLRPLARRQEDYLAADEGIATELGAVCPGLRDVTAAGAEEP
                     TAAAVEDRLSTEYETSRTLARWSVVRIGSLALGGQLPLVLLLATGPWLLSHDVTPGELV
                     GALTYVTQALLPALHNLVHGLGSAGTRLVVILRRLVPEETGEVRGAEGASGAAALPETG
                     GSVPVTGAGAGSEAGTTAPALTKTPAEPEPSPTTAPPALHLTSVTFAYGPHAEPVIRDL
                     DLVLPRGGHLAVVGPSGVGKSTLAGLVAGMLAPGSGSVLVAGRDARDEGAVARRVLIPQ
                     EAYVFGGTLGENLRYLRSDPVPDAELLDAAHAVGLGPLAERLGGLGARLEPAALSAGER
                     QLIALTRAYVAYAELAVLDEATCHLDPEAESRAERAFAARPGGTLIVVAHRISSARRAD
                     RVLVLDGPRTDCGRHGELLKRSELYRDLAGNWNPTAVAHPVLP"
     gene            complement(7983..9722)
                     /locus_tag="IE274_RS00220"
                     /old_locus_tag="GCM10010349_00430"
     CDS             complement(7983..9722)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569990.1"
                     /locus_tag="IE274_RS00220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190113472.1"
                     /transl_table=11
                     /translation="MPTTEQAAQRRLLTESTRYNTGRCLVLCLLSLAGTGAGLLLPLAI
                     GRALDAVLAGNDATGWVLWCAALVGLMAALDAGEEVLSATTAARTTLWLRGRLVRHVLA
                     VGPRATARFPAGDLVARLVGNAAQAGTAPAVLAGLFAAVAAPVGAVVALGLIDFWLAAV
                     FLGGAPVLVLLLRAFTRASSDCVAQYQTIQGDIAGRLTEAIGGARTIAAAHTERKEAAR
                     VLAPLPELARQGVRMWHVQARSQAQAVALAPLLQIGVVAMACYLILQHRLSVGELLAAI
                     RYAALATGVGVLVGQLGGLVRAKASAGRLAEVQEIPATRHGDARLPAGKGALELRGVTA
                     RRGGRTVLDGVDLTVPGGRTVAVVGRSGAGKSLLAALAGRLADPDQGTVLLDGVPLGNL
                     TRAELRRHIGYAFERPALLGATIEDTIGFGEPRPTRDSVRRAADAACADGFVRSLPEGY
                     ATTCTAAPLSGGEAQRLGLARAFARGGRLMILDDALSSLDTVTEHRVAEALLRTGPSRT
                     RLIVAHRAATAARADAVAWLEGGRIRAFDAHERLWQLPDYRGAFEQQEDGDGDGAEEGE
                     GGE"
     misc_feature    complement(9673..9686)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.48"
                     /tool="antismash"
     gene            complement(9805..9933)
                     /locus_tag="IE274_RS00225"
                     /old_locus_tag="GCM10010349_00440"
     CDS             complement(9805..9933)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983510.1"
                     /locus_tag="IE274_RS00225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00440"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_190113473.1"
                     /transl_table=11
                     /translation="MALLDLQNMESDEMTGGGGGHGGGSQVSLLLCASQASFLLCL"
     CDS_motif       complement(9871..9933)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQNMESDEMTGGGGGH"
                     /locus_tag="IE274_RS00225_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9805..9870)
                     /prepeptide="core"
                     /locus_tag="IE274_RS00225_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="18.80"
                     /molecular_weight="1995.3"
                     /monoisotopic_mass="1994.1"
                     /core_sequence="GGGSQVSLLLCASQASFLLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQNMESDEMTGGGGGH"
                     /leader_location="[9870:9933](-)"
                     /alternative_weights="2013.4"
                     /alternative_weights="2031.4"
     misc_feature    complement(9912..9926)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            complement(10001..12826)
                     /gene="lanKC"
                     /locus_tag="IE274_RS00230"
                     /old_locus_tag="GCM10010349_00450"
     CDS             complement(10001..12826)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040503.1"
                     /locus_tag="IE274_RS00230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00450"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_190113474.1"
                     /sec_met_domain="micKC (E-value: 3.1e-228, bitscore: 755.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-09, bitscore: 33.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.6e-10, bitscore:
                     35.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRYEVYCLADRHFYETPDRLSALAQAGTVYATARRAVPAGWRS
                     ERAGDWLTLVPVDDEGTALPSPQQGWKIHVSATRANADEIAAAVWDYCVPRRVPFKFVP
                     GPPLLLLRNSKYAGRDKSGKFVTVYPADEQQLHTVLRELGEILDGREGPYILTDLRWGE
                     GPLYVRYGAFTRRVCDDGRGRMVSAIEDGEGRLVPDSREPAFKVPSWVTLPDFLKPHLD
                     ARDATNVKDLPYRLEKALHFSNGGGVYVGTDTRDGRKVVLKEGRPHAGLAADGADAVTR
                     LEREKDALEKLSGLGIAPEVRDWFELGGHRFLVMDFLAGRTLNSFFADRHPLCVHEPSA
                     EDISAYTRWALRIHALVEEAVAAVHERGVVFNDLHLFNIMVAPDEQSVSLLDFEAAAGV
                     DQPGRQAVAHPGFVAPADRSGTGIDRYALACLRLALFLPVTTLLVIDREKAAHLAEVIA
                     GEFPEVPREFLDQAVAEITGAVEPEVVEAEAAEPEAAWSGTGRSEAVGSEAIPGSRTAS
                     ACRVRDFVVDPSDWPRSRDSMTAALLTSATPERDDRLFPGDVGQFAEGGGLGLAYGAAG
                     VLYALAETGAQRYEDGEHWLLKHTDPVPKGTPLGLHDGIAGIAHVLDRLGHRTRALDLV
                     GLVLEENWERLSSDLYGGLAGLGLALDGLARSTGERDLDEHALRAARILASRMVAAEAA
                     SEGAPGASGGASREGAAAAGSAQGSGSPAGSRRAGLLHGAAGPALLFLRLYDRHGAPGF
                     LDLAAQALRADLARCVPQRDGGLAVDEGWRTMPYLGDGSVGIGMVLDDYLTYRDDEQFA
                     AARTGILTAASSRFCAHPGLVQGRAGMILHLSRTQYAPGATEPSAETAARLDGQIDGLG
                     WFAMPYERHLAFPGNQLLRLSMDLHTGTAGCLLALGAALDTERPPGARAHLPFLPPLRR
                     PTDRPHREAGP"
     misc_feature    complement(12407..12409)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13040..13273)
                     /locus_tag="IE274_RS00235"
                     /old_locus_tag="GCM10010349_00460"
     CDS             complement(13040..13273)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001638.1"
                     /locus_tag="IE274_RS00235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00460"
                     /product="ferredoxin"
                     /protein_id="WP_190113475.1"
                     /transl_table=11
                     /translation="MGDRWHVEVDRSVCIGSGMCVGTAPDGFTLDTARQSHPTHPETDA
                     AEKILEAAESCPVEAITITLLGSGEVVFPPED"
     gene            complement(13273..14751)
                     /locus_tag="IE274_RS00240"
                     /old_locus_tag="GCM10010349_00470"
     CDS             complement(13273..14751)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641455.1"
                     /locus_tag="IE274_RS00240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00470"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_190113476.1"
                     /sec_met_domain="Aldedh (E-value: 2.8e-149, bitscore:
                     493.1, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELVEHGQLFIGGELVDPLGTDVIEVVSPHSGEVFARVPHAAPA
                     DVDRAVAVAREAFDNGPWPRMTLAERIEVVARIKDGVAARHEDIARVISSENGTPYTAS
                     VMVQALSAMMVWDAAITTARGFTYEEARDGVLGKILVRREPVGVVAAVVPWNVPQFTAA
                     AKLAPALLAGCPVILKTSPEAPLDAYILAEIAAAAGLPDGVLSILSADREVSEYLVGHP
                     GVDKVSFTGSVAAGKRVMEVCARNLTRVTLELGGKSAAVILPDADLAGAVAGIVPFAWM
                     INGQACVAQTRILLPRSRYDEFADAFATAASALKVGDPMDPGTELGPLVAERQQRRSLD
                     YIRIGQEEGAKILAGGGRPAGLDQGWYVEPTLFGGVDNSMRIAREEIFGPVICLLPYGD
                     EDEAVRIANDSEYGLSGSVWTADVERGIDVARRVRTGTYSVNAFSLDMLGPFGGYKNSG
                     LGREFGPEGYGEYFEHKMIHLPTGYQAPGDGGGA"
     misc_feature    complement(14907..14920)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.52"
                     /tool="antismash"
     gene            15008..16105
                     /locus_tag="IE274_RS00245"
                     /old_locus_tag="GCM10010349_00480"
     CDS             15008..16105
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012381133.1"
                     /locus_tag="IE274_RS00245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00480"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_190113477.1"
                     /transl_table=11
                     /translation="MAQASEARVIAHGGGVWSMRVPIPDNPLGYTLVHLMETDRGPVLI
                     DTGWDDPGSWDTLVAGIAACGAEVGDVHGVLITHHHPDHHGLSAKVREASGAWIALHDA
                     DADVVRRTREHAPARWYGYMADKLAAAGAPAEHVAPLLAARDAGRTPRLPGLAPALPDR
                     SIVPGELLPLAGRRLRAIWTPGHTPGHVCLHLEEAHPAGLPGHGRLFSGDHLLPGITPH
                     IGLYEDPDDATAVAPSPSSRPRPSGGDPLGDYLDSLERVGRLGVAEVLPAHQHAFTEAR
                     PRVRELLTHHEERLTQLRTLLTEPRTPWQLAEHMQWNRPWADIPYGSRNIAVSEAEAHL
                     RRLVKLGRAEAVAGSDPVTYVACGA"
     misc_feature    complement(15033..15048)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            complement(16153..16986)
                     /locus_tag="IE274_RS00250"
                     /old_locus_tag="GCM10010349_00490"
     CDS             complement(16153..16986)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641452.1"
                     /locus_tag="IE274_RS00250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00490"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190113478.1"
                     /transl_table=11
                     /translation="MAGTATERDARPGGRDGARVCLVTGAASGIGRAVARRLTGRGHRV
                     IGADLKDTDGVDIQADLATADGRALLADAAAELGGGRLDAVVACAGVGAYDPVTVRVNG
                     FGAIATLAGLRPLLAAGRDPRALAVSSVAAVHETDPAIVAAVLADDEDAAVAAAQAAVD
                     RGEGGLVYASAKRALVRWVRRAAITDAWAGAGIPLNVIAPGIIRTPLSRAIIENPEMRA
                     VADRAVPMPLHGYADPEQVAPLVEHLTAPENTHVTGQVVFIDGGADAVLRGDEVW"
     misc_feature    17167..17182
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     regulatory      17182..17262
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            17400..18641
                     /locus_tag="IE274_RS00255"
                     /old_locus_tag="GCM10010349_00500"
     CDS             17400..18641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103398.1"
                     /locus_tag="IE274_RS00255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00500"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_190113479.1"
                     /transl_table=11
                     /translation="MNVRRSAAALAVAVAALGTAAAPAAFADDDSPSAKATGAPLPSGL
                     YGKKDPQFDGVFRQSYALLAQKTVGVTPAAKAVDWLTGQQCTSGGFAAYRADASEPCGS
                     KTQVDSNSTAAAIQALHAVGNESNTVKKGLGWLKSVQNQDGGWGYNPGLPSDANSTGIV
                     VGALAAVGEKPASVKSQKGKSPLDALTKLAMDCGKDGGAFGLADAKSGKLAPNADATAA
                     GVLGGLGQGLVPAKGKKADAAPKCAKPDTAKQAADNGTGYLLKTLAKTGHLTSAMPGAK
                     DQPDVGNTADAVVALAAAGQQEQAKKSAEWLSENSAAWAKDSGPAAYSQLVFAALAADM
                     DVRDFGGADLVKQLNAQGPTPKAISETTAAAKEKDEKDDDGSGVSVWWIVGVGLVAGAG
                     IGFLLSGRKKKNQL"
     gene            18638..19309
                     /locus_tag="IE274_RS00260"
                     /old_locus_tag="GCM10010349_00510"
     CDS             18638..19309
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511742.1"
                     /locus_tag="IE274_RS00260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00510"
                     /product="SCO2322 family protein"
                     /protein_id="WP_190113480.1"
                     /transl_table=11
                     /translation="MSRRHPGRGRLTVAALLTALLALPAALLAGSPAHAADYRYWSFWQ
                     RGEGGAWVYATQGPSIARPDDGDVEGFRFAVSANSGSAEKPRGAADFDTICADTPARDG
                     QKRVALVIDFGTRDDAPGGEQPPKRRTACARVASDGTSAEALAAVAGQLRYNSSALLCA
                     ISGYPKQGCGEQVSGKKSDDAGSARQDGDDGGPSVGLLAGIAAIVALGAAAVWQARRRR
                     G"
     gene            19269..20486
                     /locus_tag="IE274_RS00265"
                     /old_locus_tag="GCM10010349_00520"
     CDS             19269..20486
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380120.1"
                     /locus_tag="IE274_RS00265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00520"
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /protein_id="WP_190113481.1"
                     /transl_table=11
                     /translation="MPPPSGRPAAAVADAAPDRLLPRRLAPQAHRSNALHPGAWWLWAL
                     GLATAASRTTNPLLIGLLIGVAGYVVAARRTSAPWARSYGAFVKLALVVIGIRLVFAIV
                     LGSPIPGTHLIVTLPEVPLPDWAQGVRIGGRVTAEGVVFALYDGVRLAGLLICVGAANA
                     LASPARLLKSLPGALYEAGVAVVVAMTFAPNLISDVQRLRAARRLRGRPDKGVRGLLQV
                     GLPVLEGALERSVALAAAMDARGFGRTAAVPARVRRTTAVLTLGGLMGVCAGAYGLLTA
                     DGSTYGLPVLGAGLAAALGGLWLGGRRSVRTRYRPDRWGARAWLVAGSGAAVAALMIAA
                     NSAAADALHPGVIPLIAPTLPLLPAAAVLIGLLPAFVAPVPPPAEAPVPARATRTARTA
                     AEEKAS"
     misc_feature    complement(20501..20514)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            20501..22321
                     /locus_tag="IE274_RS00270"
                     /old_locus_tag="GCM10010349_00530"
     CDS             20501..22321
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093335.1"
                     /locus_tag="IE274_RS00270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00530"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190114049.1"
                     /transl_table=11
                     /translation="MIRFEDVSVRYEGTAAPTVQGVDLSVPEGELVLLVGPSGVGKSTL
                     LGTVSGLVPHFTGGTLRGRVTVAGRDTRTHKPRELADVVGTVGQDPLAHFVTDTVEDEL
                     AYGMESLGLAPDVMRRRVEETLDLLGLADLRDRPITTLSGGQQQRVAIGSVLTPHPRVL
                     VLDEPTSALDPAAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADQVLLLPAPGEPP
                     LLGDPAEVMAVSPVYPPVVGLGRLAGVAPLPLTVRDARRRTGGLRERLAGMAPSGVVPP
                     GGEPAGVAPAEVADEGRAVVAPGARAAEVDAPGRVSRWRRHRGKRHEAEATTPGAASPA
                     VARPEGTAPAAGTPAARVAGLAVLRGRVEALRRVDLAVSPGATVALMGRNGAGKSTLLS
                     TLVGLLPPTSGTVRVGGAAPHRMPPRELIRHVGLVPQEPRDLLYADTVTAECAAADRDA
                     DAAPGTCRDLVADLVPGIADDTHPRDLSEGQRLALALAIVLTTRPPLLLLDEPTRGLDY
                     AAKARLVTILRGLAARGHAIVLATHDVELAAELAHRVVILADGEVVADGPTADVVVSSP
                     SFAPQVTKVLAPQRWLTVTQVREALEAADE"
ORIGIN
        1 actggtacgt cgccccggcg gcgagccccg cgttggcgac gaaccgggtc ttcgcgagct
       61 tctggcgttc gaccgtgctc gtgggcgtcg cggcggagtc cttgtcgtcg ccgtcgcacg
      121 ccgccgtcgt gcccgcgagg agggcgcaga ggagcagggg gacgagggcg cggagcaggg
      181 agcggggcac ggtgacctcc gggcgggtgg gggcggccgc cgccagcctc acccggtgcg
      241 gccgggcccg ccaccggggc gcggccagcg gggtggacgg gccacggcac ggctggatcg
      301 acaccccgcg gcccacgtga ccgccacccc acggcccgca tgacggccac cccacggccc
      361 gcatgacggc caccccgcgg cccacgtgac ggccaccccg ccccagccga agcggcaccc
      421 caccgccccc aggtttcggc cacccctccc ccggtacccg ccccccatgt cccccgtaca
      481 caaacaacgc acgacggaag ccgccaaggt cgtcgtcgtc atcgcggacg tgatggcctt
      541 catcctcgcc ctgtgggtcc tgatggacct gctggacgcc aaccgtgcca atgacctcgt
      601 gcaggtcgtg catgattccg cccgctggct cgcgagctgg tcgcacgatc tgttcacgtt
      661 cgacgagcgc tgggcccgcg tggtcgcggg gtacggcctc gcggcggtcg tctacctcgt
      721 cgcggggcac ttcctcgcgg ggcggctgcg gcggcactga gcgccgcgcc gacccggccg
      781 caccgccccc ggggcccggg gcctcagccg cagcagtccg gctccaggcc gaccggaagt
      841 cccgctcccg agaacacccc gcacgtcgcc tcgtccccgc ccagcgccgc caccgcgagc
      901 agcagggagc ccgccgtcca cgtggtcagc tcgacgggcc agatcgcggc gtcctcgaag
      961 acgtagccgg tccagtagag gccggactcg ggatcgcgga ggtgctggat ggacttgagg
     1021 atgtcgaggg cgcggtcgga ctcgccgagg gcccagaggg cgagggcgag ttcggcgctc
     1081 tcgccgccgg tgacccacgg gttggggtgc acgcagcgga cgccgaggcc ggggacgacg
     1141 aagcggtccc agccttcttc tatgcgggac ttggcttccg gcccggtgac cgcgccgccg
     1201 aggaccgggt agtaccagtc catggagtag cggtccttgt cgaggaagcg ctcggggtgg
     1261 tggcggatgg cgtggccgag ggcgcccgtc gccagctccc agtccggctg cgggtcgtcg
     1321 cgcaggtcgg cgagggcgag ggcgcagcgc aaggcctggt agacggagga gcagccggtg
     1381 aggagcgcgt ccgggacggg ggtgccgtcg gggtcgcgct tccagccgat ctggccgccg
     1441 ggctgctgga gtgcgaggac gaactcgacg gccgcgacga cgacgggcca catgcggtcg
     1501 aggaaggcct cgtcgccggt gctgaggtag tggtgccaga cgccgacggc gacgtacgcg
     1561 cagaagttgg tctcgcggcc gcggtcggtg acgtcgtcgg ggtcgccgtc ggcataggcc
     1621 gcgtaccagg agccgtccgg gttctggtgc cgggccagcc actcgtaggc gcgggcggcg
     1681 gccgcgtgct cgccggcggc gtccagggcc atggcggcct cggtgtggtc ccacgggtcg
     1741 aggtggtggc cgcggaacca gggtatggcg ccgtccgcgc gctggacggc gaggatgccg
     1801 cggaccgtgg ccgtcgcctg atcggccgtc agaacgcccg gcaggaccag gtgttcggtg
     1861 cgctcgggaa tcgtcacgcc ccggccttcg tgtcggcggc cgggtcggtg gtggcggtgc
     1921 ggggcaggtg cggcttggtc gcgtacgcca cgaagctctt gccgacgacc gggttgagga
     1981 gctgctcggc gacgcgggtg gcccggggct tcttcatgat gtcccagacc aggagcttgt
     2041 ggtacgcccg caccggcagc gctgcgtctt tgccgtcctt gccgactccg aacgcgcact
     2101 tcagccacca gtacggcgag tgcagcgcgt gcgcgtggtg ggtgccgtac ggcttgaggc
     2161 ccgactcccg catcctggcg aggagttcgt cggccttgta gatgcggatg tggccgccct
     2221 cgacctcgtg gtaggcgtcg ctgagcgccc agcagacctt ctccgggccg tagcgcggca
     2281 cggtcacggc tatccggccg cccggcttga ggacccggac catctcggcg agcacgccct
     2341 tgtcgtcggg gatgtgctcc atcacctcgg agatgatgac gacgtcgaac gactcgtcgg
     2401 ggaacggcag gttgagggcg tcgccctcca tggcggtggc ggtcgcgccc gccggggcct
     2461 cgcccgcctc cttcatcgcc gcgaaccact tggcgacctc gcggatctcg tccgcgttct
     2521 ggtccagggc gaccacccgg gcgccgcgcc ggtagcactc gaaggcgtgc cggcccgccc
     2581 cgcagcccag atcgagcacg cggtcccccg cggcgagcgg gaagcgggtg aagtcgacgg
     2641 tcagcacgtg gccctgcttt cgggttgagg tcctgcaact tcgccggaga ccgcggtggc
     2701 ggccgtcggc agcgcgggtg cgccggtggc cccggccgtc ggcagcgcct gcccgcgggc
     2761 caccgcgcgg gcggcgcccc ggctcgcgga gcggtcgatc gcctcgcggt acaactccgc
     2821 ggtgccctgg gcggcgcggg cccaggtgaa ccggtcgagg acccgcgcgc ggcccgcggc
     2881 gccgagccgc gcccgcagtg ccgggtcgcc gaggagccgg gtgaggcccg cggcgagcgc
     2941 gcccgcgtcg cccggaggca ccgcgaggca ggtgtcgccg tcgcggcccg cgacctccgg
     3001 gatcgccccg ccggtggtgg cgagcagcgg tgtcccggtc gccatggcct cggcggcggg
     3061 cagcgagaag ccctcgtaca gggacggcac gcaggcgatc tgggccgagc ggaccaggtc
     3121 caccagttcc tcgtcggtga tgcccttgac gaactcgacg gcgccctgga ggccgtactt
     3181 ctcgatggcc tgtgccaccg ggccgtcctc ggcgcgcttg ccgacgacga cgaggtgcgc
     3241 cgcggggttc tcggtgcgga ccttggcgag cgcctcgacg aggtggatca ggcccttgag
     3301 gggtacgtcg gcgctggacg tcgtcacgat ccggcccggc acctcgggca ccgccgggtc
     3361 gggcgagaag agggtggtgt cggcgccgat gtggacgacg ttgacgcggt cgcggcggac
     3421 gccgaggtgg tcgacgatct cctggcgcga ggtgccggac acggtgagga tcgacggcag
     3481 gcggcgcgcg acgcgcttct gcatccgcgt gaacgcgtac cagcggcgca cggacgcccg
     3541 gcgcttccag tcgggcgcgg cgtccagctc caggcggcgg tcgacggtga tggggtggtg
     3601 gacggtcgtc accagggggg cgcccaggtc gccgaggagg ccgtagccga gcgtctggtt
     3661 gtcgtgcacg acgtcgaact cgccgcgccg ggcgcgcagg tggcggcggg cgcgcaggct
     3721 gaaggtgacc ggctcgggga agccgccggt ccacatcgtg ccgacttcga gggcgtcgat
     3781 ccagtcgcgg tactcgtcgc gcttcggggt ccggaagggg tccggggagc ggtagaggtc
     3841 caggctcggc agctcggtga ggctgagccc gcgcaggtcc tcgccctcgt cgagcacggg
     3901 gtagggctgc gcgccgatga cctcgacgcg gtgaccgagg cggaccagct cacgggagag
     3961 gtggcgtacg tagacaccct ggccgccgca gaacgggttc cccttgtacg tgaggagcgc
     4021 gatgcgcagc cggcggccgc cgtcggcggc cgtgcccggc ggcacgtccg gcgtcgtccc
     4081 cggggtcgcg cccggcaccg gccccggcag gggacccgcc tccatggcct cagcggtcac
     4141 tctggccccc ttctgccttc agttgtccgc gagattacgc cgggacggta atctagaaca
     4201 agtttcagac ttgttcccgt catgatcgtc cttgatcgcc ggacccgctc gaatctaccg
     4261 gcaggtagcc gggccggaag gtccggatca ggtgattcgc gccacggcgg ccgccctgcc
     4321 atgctgtgcg gtcccgatga acgggcacgg ccgggcacgg ccaggaacgg cacggggacg
     4381 gggcgggact gacggacacc gctgacggga ctgacggggc gacgggacta tgacggctga
     4441 cgcgaagacg gcggcgggag cgggcgcggc acatccggcg tcgccgcccc tcaccgagcg
     4501 ccaggaggcg cgccgccgcc gcatcctgca cgcgagcgcc caactggcga gccgaggcgg
     4561 cttcgacgcc gtccagatgc gggaggtggc ggagtcgtcg agcgtcgcac tcggcacgct
     4621 ctaccgctat ttcccgtcga aggtgcacct gctcgtcgcg acgatgcagg accagttgca
     4681 gcacatgcac accacgctgc gcaaacaccc cccggccgga cggaccccgg cggagcgtgt
     4741 cgccgagacc ctgatgcggg ccttccgcgc cctgcagcgc gagccgcacc tagcggacgc
     4801 gatggtgcgc gccctcacct tcgccgaccg gtcggtgagc ccggaggtcg acacggtctc
     4861 gcggctcacc acggcgatcg tcctggacgc catgggcctg gacgggcagc ccaccgccgc
     4921 acagctctcc gcggtgcggg tcatcgagca cacctggcac tccgcgctga tcacctggct
     4981 gtcggggcgc gcctcgatcg cccaggtcaa gatcgacatc gagatggtgt gccggttgat
     5041 cgacctgacg gtgcccgagt ccgcctgagg gtgcccgagc ctgccggacg gtgccagggt
     5101 ccgccggatg gcacccagtc cgccggatgg tgccgagtcc gccggatggt gcccgattcg
     5161 tcccgatggc acgcccgccg gacggcgccg acgcggcggc cgacgcatcg taggggctca
     5221 gtgacaccac gtaggggcag agtgcgttct tccggccggt gagctgtcgc acggggggcg
     5281 cacttggttc ggacatatgc gccccctggc atcgcgttgg ccagttctca gcgtccatga
     5341 cagccacact tcggctttca atggtctgcg caatgctcgg cacgccggcg aacagccggg
     5401 gccgggacac caggtggggt tcggacggcg ttcgggtggg actcgaagca ggaggggcga
     5461 gtaacgcggc ccggaccgga acctggagga gcacggggct ggaggggcag aaacgtgatc
     5521 cgggtacttc tcgtgcacga cgcctgtctg ctgcgatcgg ctctggcgga acgactcgcc
     5581 cgtgagcccg acttggaggt gttccacacg ccatggggtg ccgcccgacg ccgcctcggc
     5641 tcggtgcggc ccgatctgtg cgtcgccgat ctcgactgcg agaccgggta cgcgctcgcg
     5701 ccgctcggcg agctcaagac caccgcgacc ggcacgggca cccgctgccc gctgctcgtc
     5761 ctcgcctcgg cgcaccggcc ggggctgctg cgccgggccc tggacgcggg cgcggtcggc
     5821 ttcgtcgaca aggcgagcgt gcccgagcag ctgctcaccg cgatcagaca ggtggcggcc
     5881 ggggtgcgct acgtcgacga ctcgctcggc ttcggattcc tgaaggccgc ccagatgccg
     5941 ctgacccagc gggagttgag cgtgttgacg ctggccgccg gaggggcgtc cgtcgcggag
     6001 atagcgcacc ggctacatct gtcgaacggc acggtacgca actacatggc cgcgatcacc
     6061 cggaagaccg gggcccgcaa caaggtcgac gcgatcagga tttccttagg ggagggctgg
     6121 gtgtgatcag ggcaggaccg ggtgcgcgac ggccgtcggg ttccagttgc ccgccaggtc
     6181 gcggtacagc tccgagcgct tgagcagttc gccgtgccgg ccgcagtccg tacggggtcc
     6241 gtcgaggacc aggacgcggt cggcgcggcg ggccgagctg atgcggtgcg cgacgacgat
     6301 gagcgtgccg ccgggccggg cggcgaaggc gcgctcggcg cgggactccg cctccgggtc
     6361 gagatgacag gtcgcctcgt cgagcacggc gagttcggcg tacgcgacat aggcgcgggt
     6421 cagggcgatg agctggcgtt cgcccgccga cagcgccgcc ggttcgagcc gcgccccgag
     6481 cccgccgagg cgctcggcga gcgggccgag gccgacggcg tgggcggcgt cgaggagttc
     6541 ggcgtccggc accgggtcgg agcgcagata gcgcaggttc tcccccaggg tgccgccgaa
     6601 gacgtacgcc tcctgcggga tgaggacgcg gcgcgccacc gccccctcgt cccgcgcgtc
     6661 ccgcccggcc accagcacgc tgccgctccc cggcgccagc atccccgcga cgaggcccgc
     6721 gagcgtcgac ttgccgaccc cgctgggccc gacgacggcc aggtgcccgc cgcgcggcag
     6781 gaccaggtcg aggtcgcgga tgacgggttc ggcgtggggg ccgtaggcga aggtgacgga
     6841 ggtgaggtgg agggcggggg gtgccgtcgt cggggatggt tccggctcgg cgggggtctt
     6901 cgtcaaggcg ggcgcggtgg tcccggcctc ggacccggcc ccggccccgg tcaccggcac
     6961 cgagccgccg gtctccggaa gtgccgccgc cccggaagcc ccctcggccc cccggacctc
     7021 ccccgtctcc tccggcacca gccgccgcag gatcaccacc aggcgtgtgc ccgccgagcc
     7081 caggccgtgg accaggttgt gcagggccgg gaggagggcc tgggtgacgt aggtgagggc
     7141 gccgacgagt tcgcccgggg tgacgtcgtg ggacaggagc caggggccgg tggcgagcag
     7201 cagcacgagg gggagctggc cgcccagcgc gagggagccg atgcggacga cggaccagcg
     7261 ggccagggtg cgtgacgtct cgtactcggt gctgaggcgg tcctcgacgg cggcggccgt
     7321 cggctcctcg gcgcccgcgg cggtgacgtc ccgcaacccg gggcagacgg cgccgagttc
     7381 ggtcgcgatg ccctcgtcgg cggcgaggta gtcctcctgg cggcgggcca gcgggcgcag
     7441 ggtcaggacg aacaggccga cacccgcgac cagcggcggc gccacgacca ggacgagcag
     7501 cggggccagg gtgcacaggc cgatcagcgc acccacggcc gtgaacacga aggaccgcga
     7561 caccatcacc aggcccgcga aggtgtcccg cgcggtctcc acctgctggg tgagccgcga
     7621 cacggcggcg ctgtcggcct cctcgatgcc gcgcgccacg acgtgccgca cgagcacgtc
     7681 ccgcatcggc tcgaccagcc gggccaccgc acggaacacc tgcccggtgc cgtacgccgc
     7741 gaccagcacc ccgcccgcgg cggcgagcag ccagccgaga ccgacggctc cgtctccggc
     7801 gaggaacccg tcgtcgaggg cgtgcgccag ggcgtacccg gtgaggaagg tctggccggt
     7861 ctccaggacg gaccagaagg cgatctgggc gaccacccac cggcgctcgc gcaggaagcg
     7921 ggcgccgcgg gcgtaggtgc ccgtgccgcc gcctgacgct gcgccgctcc cgcccttgcg
     7981 gctcactcgc ctccctcccc ttcctcggct ccgtccccgt ccccgtcctc ctgctgctcg
     8041 aacgcccctc tgtagtccgg gagttgccac agccgttcat gcgcgtcgaa ggcacggatc
     8101 cggccgcctt cgagccaggc cacggcgtcc gcgcgggcgg cggtggcggc gcggtgggcg
     8161 acgatcaggc gggtgcggga cggaccggtg cgcaacaggg cctccgcgac gcggtgctcg
     8221 gtgaccgtgt ccaggctgga gagggcgtcg tcgaggatca tgagccgccc gccccgggcg
     8281 aacgcgcggg ccaggccgag gcgttgggcc tcaccaccgg acaggggcgc ggccgtgcag
     8341 gtggtggcgt agccctcggg gaggctgcgg acgaacccgt cggcgcaggc ggcgtcggcg
     8401 gcgcgccgga cgctgtcgcg ggtggggcgg ggttcgccga agccgatggt gtcctcgatg
     8461 gtggcgccga gcagcgcggg ccgctcgaag gcgtagccga tgtggcggcg cagctccgcg
     8521 cgggtgaggt tcccgagcgg tacgccgtcc aggaggaccg tgccctgatc ggggtcggcg
     8581 agacggcccg cgagggcggc gagcagtgac ttgcccgcgc cggagcggcc gacgacggcg
     8641 acggtgcgcc cgccggggac ggtcaggtcg acgccgtcga gaacggtgcg cccgccgcgc
     8701 cgggcggtga cgcctcgtag ctccaaggcg ccttttcctg cggggagtcg ggcgtcgccg
     8761 tgccgggtgg ccggtatctc ctggacctcg gcgagcctgc ccgccgaggc cttggcccgc
     8821 accaggccgc cgagctggcc caccagcacg ccgacgccgg tggcgagggc cgcgtaccgg
     8881 atggccgcga gcaactcccc caccgacaag cggtgctgga ggatcaggta gcacgccatg
     8941 gcgacgacgc cgatctgcag gagcggcgcg agggcgacgg cctgggcctg cgagcgcgcc
     9001 tgcacgtgcc acatccggac gccctgccgg gcgagttcgg gcagcggcgc gagcacccgc
     9061 gccgcctcct tgcgctcggt gtgcgcggcg gcgatggtcc gggccccgcc gatcgcctcg
     9121 gtgagacggc ccgcgatgtc gccctggatg gtctggtact gggccacgca gtccgacgac
     9181 gcccgcgtga acgcccgcag gagcagcacc agaaccgggg ccccgccgag gaagacggcc
     9241 gcgagccaga agtcgatgag gccgagcgcc acgacggcgc cgacgggtgc ggcgacggcc
     9301 gcgaagagcc cggcgagcac ggcgggcgcg gtaccggcct gcgccgcgtt gccgaccagg
     9361 cgggccacca ggtcaccggc cgggaagcgg gcggtggcgc gcgggccgac ggcgagaaca
     9421 tgacgtacga gacggccgcg cagccacagg gtggtgcggg cggccgtggt cgcggagagc
     9481 acttcctcac cggcgtcgag ggcggccatg aggccgacga gggcggcgca ccacagcacc
     9541 cagccggtcg cgtcgttccc ggcgagcacg gcgtcgaggg cgcggccgat ggcgagcgga
     9601 aggagcaggc ccgctcccgt gcccgcgagg ctgagcaggc acaggacgag gcagcgcccc
     9661 gtgttgtacc gggtggactc ggtcaagagg cggcgctgtg cggcctgttc ggtggtcggc
     9721 atggcggggc gggacctctc ggaagccgtc gagcccgggc ggcccaccga ggtggcgccg
     9781 cccgggcccg tcactgactt gagctcacag acaaagcagg aagctcgcct ggctggcgca
     9841 cagcagcagg ctgacctggc tgccgccgcc gtggccgccg ccgccaccgg tcatctcgtc
     9901 ggactccatg ttctgcaggt cgagaagcgc catcgtcgtg cctttcttta tggggacatc
     9961 gtgcgttgtg gtggtactgg ccgtgcgggt ggtgcgtttt tcacggcccc gcctcgcggt
    10021 ggggccggtc ggtgggccgc ctcaggggcg gcaggaacgg caggtgggcg cgggcgccgg
    10081 ggggccgttc ggtgtcgagc gcggcgccga gggcgagcag gcagcccgcg gtgccggtgt
    10141 gcaggtccat ggacaggcgc agcaactggt tgccggggaa ggcgagatgg cgctcgtacg
    10201 gcatggcgaa ccagccgagg ccgtcgatct ggccgtcgag gcgggcggcg gtttccgcgc
    10261 tcggctcggt cgcccccggc gcgtactgcg tgcggctcag gtgcaggatc atccccgcgc
    10321 ggccctggac gagcccgggg tgcgcgcaga agcgggagct cgcggcggtc aggatgccgg
    10381 tgcgggccgc ggcgaactgc tcgtcgtcgc ggtacgtgag gtagtcgtcg aggaccatgc
    10441 cgatgccgac gctgccgtca cccagatagg gcatggtgcg ccagccctcg tccacggcga
    10501 gccccccgtc gcgctgcggc acgcaccggg cgaggtccgc gcgcagggcc tgggcggcca
    10561 ggtccaggaa gcccggggcg ccgtggcggt cgtacaggcg caggaagagc agggcgggtc
    10621 cggcggcgcc gtggaggagc ccggcgcgcc gcgaaccggc cggtgagccc gacccctgtg
    10681 cggaccccgc ggcagccgcg ccctccctgg aagcgccccc ggaagccccg ggcgctccct
    10741 ccgaagccgc ctccgccgcc accatccggc tcgccaggat ccgcgccgcc cgcagcgcgt
    10801 gctcgtccag gtcccgctcc cccgtggaac gggccaggcc gtccagggcg aggccgagac
    10861 cggcgaggcc gccgtacagg tcggacgaca ggcgctccca gttctcctcc aggaccaggc
    10921 cgacgaggtc gagggcgcgg gtgcggtggc cgaggcggtc caggacgtgg gcgatgcccg
    10981 cgatgccgtc gtgcaggccg agcggggtgc ccttgggcac ggggtcggtg tgcttcagga
    11041 gccagtgctc cccgtcctcg taccgctgcg cgccggtctc ggcgagcgcg tacagcactc
    11101 cggccgcgcc gtacgcgagg ccgagcccgc cgccctcggc gaactgcccg acgtcaccgg
    11161 ggaagagccg gtcgtcacgc tccggtgtgg cggaggtgag gagggccgcg gtcatggagt
    11221 cgcggctgcg gggccagtcg gacgggtcga cgacgaagtc ccgtacgcga caggccgagg
    11281 cggtccgact cccggggatc gcctcactcc ccacggcctc gctccggccg gtcccgctcc
    11341 aggcggcctc gggctcggca gcctccgcct cgacgacctc cggctccacg gcccccgtga
    11401 tctcggcgac cgcctggtcc aggaactccc tcggcacctc cgggaattcg cccgcgatca
    11461 cctccgccag atgcgccgcc ttctcgcggt cgatgaccag gagcgtggtg acgggcagga
    11521 acagggccag gcgcaggcag gcgagggcgt agcggtcgat gccggtgccg ctgcggtcgg
    11581 cgggcgccac gaagccgggg tgcgcgacgg cctggcgtcc cggctggtcc actccggcgg
    11641 cggcctcgaa gtcgaggagg gagacggact gttcgtcggg cgcgaccatg atgttgaaca
    11701 ggtgcaggtc gttgaagacg acgccgcgct cgtgcacggc ggcgacggcc tcctccacca
    11761 gggcgtggat ccgcagggcc cagcgcgtgt acgcggagat gtcctcggcg gacggctcgt
    11821 ggacgcacag cggatggcgg tccgcgaaga aggagttgag ggtgcggccc gccaggaagt
    11881 ccatgacgag gaagcggtgg ccgccgagtt cgaaccagtc ccgcacctcg ggggcgatgc
    11941 cgagccccga cagcttctcc agggcgtcct tctcgcgttc caggcgggtg acggcgtcgg
    12001 cgccgtcggc ggcgaggccc gcgtgcggac ggccctcctt caggacgacc ttccggccgt
    12061 cgcgggtgtc cgtaccgacg tacacgccac cgccgttgga gaagtgcagg gccttctcca
    12121 ggcggtacgg gaggtccttg acgttggtcg cgtcgcgggc gtcgaggtgc ggcttcagga
    12181 agtcgggcag cgtcacccag gacggcacct tgaaggccgg ttcgcgcgag tccggcacga
    12241 gccggccctc gccgtcctcg atcgcggaga ccatccggcc gcgcccgtcg tcgcacacgc
    12301 ggcgcgtgaa ggcgccgtag cgtacataca gcgggccctc gccccagcgc agatcggtga
    12361 ggatgtaggg accctcgcgg ccgtcgagta tctcgcccaa ctcacgtaac acagtgtgta
    12421 gttgctgttc gtcggcgggg tacacggtga cgaacttgcc gctcttgtcg cggcccgcgt
    12481 acttgctgtt gcgcagcagg agcagcggcg ggcccggcac gaacttgaac ggcacccggc
    12541 gcggcacgca gtagtcccag acggccgcgg cgatctcgtc ggcgttggcc cgggtggcgg
    12601 agacgtggat cttccagccc tgctggggcg acggcagcgc ggtgccctcg tcgtcgacgg
    12661 ggaccagggt cagccagtca ccggcgcgct cggagcgcca gccggcgggg acggcgcggc
    12721 gggcggtcgc gtacaccgtg ccggcctgtg cgagcgcgga cagccggtcc ggggtctcgt
    12781 agaagtgtct gtcggccaga cagtagacct cgtaccgctt gtccatgggt cccctccccg
    12841 cgctgtgtcg cgatgagact tccaggacac cccgggggcc ggacagtcac gtctgtcatc
    12901 gactcaccgt gcggaactca tgcgtaaagt cacgttcgag cggacttcga gcatgtgatg
    12961 gcggtccggt gtacggggcc cgcgcagggc cgtgagtgcc gggtgccgca cggcgggcgc
    13021 ggggcggtgt cggcgggttc tagtcttccg gcgggaacac cacctccccg ctgccgagca
    13081 gcgtgatggt gatggcctcg accgggcagc tctcggccgc ctccaggatc ttctcggcgg
    13141 cgtccgtctc ggggtgcgtg gggtgcgact ggcgggcggt gtcgagggtg aagccgtccg
    13201 gcgcggtgcc cacgcacatc ccggagccga tgcacaccga ccggtcgacc tcgacgtgcc
    13261 agcggtcgcc catcaggcac cgcccccgtc accgggggcc tggtacccgg tgggcaggtg
    13321 gatcatcttg tgctcgaagt actcgccgta gccctcgggc ccgaactccc gccccagacc
    13381 ggagttcttg tagccgccga acgggccgag catgtcgagg ctgaaggcgt tcacggagta
    13441 cgtgccggtg cgcacccggc gcgccacgtc gatgccgcgc tcgacgtcgg cggtccacac
    13501 gctgccgctg aggccgtact cggagtcgtt ggcgatgcgg acggcctcgt cctcgtcgcc
    13561 gtacggcagc agacagatga cggggccgaa gatctcctcg cgggcgatgc gcatggagtt
    13621 gtcgacaccg ccgaagagcg tcggctccac gtaccagccc tggtcgagcc ccgccggacg
    13681 gccgcccccg gccaggatct tggcgccctc ctcctgcccg atccggatgt agtcgagcga
    13741 gcggcgctgc tgccgttcgg ccaccagcgg gccgagttcg gtcccggggt ccatcgggtc
    13801 accgaccttc agggcggacg cggcggtggc gaaggcgtcg gcgaactcgt cgtagcgcga
    13861 gcgcgggagc aggatgcggg tctgggccac gcacgcctgg ccgttgatca tccacgcgaa
    13921 cggcacgatc ccggcgacgg cgcccgcgag gtcggcgtcg gggaggatca cggcggccga
    13981 cttgccgccg agttccaggg tgacgcgggt gaggttgcgg gcgcagacct ccatcaccct
    14041 cttcccggcg gcgacggagc cggtgaagga caccttgtcg acgcccgggt gcccgaccag
    14101 gtactcactg acctcgcggt cggccgagag gatcgagagc acgccgtccg ggagccccgc
    14161 cgcagcggcg atctcggcga ggatgtacgc gtcgagcggc gcctccggcg aggtcttcag
    14221 gatcaccggg cacccggcga gcagcgcggg cgcgagcttg gcggcggcgg tgaactgcgg
    14281 gacgttccac ggcaccacgg ccgcgacgac gccgacaggc tcgcgccgca ccaggatctt
    14341 cccgagcacc ccgtcccgcg cctcctcgta cgtgaagccg cgcgcggtgg tgatcgccgc
    14401 gtcccacacc atcatcgccg acagcgcctg caccatcacg gacgcggtgt acggggtgcc
    14461 gttctcggag ctgatgacgc gcgcgatgtc ctcgtgccgc gccgcgaccc cgtccttgat
    14521 ccgcgcgacg acctcgatcc gctcggccaa cgtcatgcgc ggccagggcc cgttgtcgaa
    14581 ggcctcgcgc gcgacggcca cggcccggtc gacatcggcg ggcgcggcgt gcggcacccg
    14641 cgcgaacacc tcaccgctgt gcggcgagac cacctcgatg acgtccgtgc cgagcgggtc
    14701 gaccaactcc ccgccgatga acagctgtcc gtgttccacg agctcgctca tgactgcctg
    14761 cctcctgcga atgctgcggc tgctgcttgc ggctgccgag gccgccgcgt gcgactcctg
    14821 cggctgcttg cgactgctgc ggctgcttgc gactgctgct acggctcgga cgccttgccg
    14881 agcagtttct gacgctgttt cagaactgat accagttcta gttatagtgg gcaatggccg
    14941 cgcgcccgcg ccgagtcggg ctcggcggag gcggcggggc gaggcacccg gcggcgaggg
    15001 ggagcggatg gcgcaggcga gcgaggcgcg ggtgatcgcg cacggcggtg gcgtgtggag
    15061 catgcgggtg cccatcccgg acaatccgct cgggtacacc ctcgtgcacc tcatggagac
    15121 cgaccgcggg cccgtcctga tcgacaccgg ctgggacgac ccgggctcgt gggacacgct
    15181 ggtcgcgggg atcgccgcgt gcggggccga ggtcggggac gtgcacgggg tgctgatcac
    15241 gcatcaccac cccgaccacc acgggctttc cgcgaaggtg cgggaggcct cgggagcgtg
    15301 gatcgccctg cacgacgccg acgcggacgt cgtgcggcgc acccgtgagc acgcgcccgc
    15361 gcgctggtac gggtacatgg ccgacaagct cgccgccgcg ggcgcgcccg ccgagcacgt
    15421 ggccccgctg ctcgccgccc gggacgcggg ccgcaccccg cggctccccg gcctcgcccc
    15481 cgccctgccc gaccggtcca tcgtccccgg cgaactcctg cccctggccg ggcgccgcct
    15541 gcgcgccatc tggaccccgg gccacacccc cggccacgtc tgcctgcacc tggaggaggc
    15601 ccacccggcc gggctccccg ggcacggccg cctcttctcc ggcgaccacc tgctgcccgg
    15661 catcactccg cacatcggcc tgtacgagga tcccgacgac gccaccgccg tcgccccttc
    15721 gccgagttcc cgacctcgcc cgagcggagg cgaccccctc ggcgactatc tggactccct
    15781 ggagcgggtc ggacggctcg gcgtcgcgga ggtgctgccc gcccatcagc acgccttcac
    15841 cgaagcccgc ccccgcgtac gggagttgct gacccaccac gaggagcgcc tcacccagct
    15901 ccgcaccctg ctcaccgagc cccgcacccc ctggcagctc gccgagcaca tgcagtggaa
    15961 caggccctgg gccgacatcc cctacggctc acggaacatc gcggtgtcgg aggcggaggc
    16021 gcacctgcgg cgcctggtga agctggggcg ggcggaggcc gtggcgggga gtgatccggt
    16081 gacgtacgtg gcgtgcgggg cgtagcccct gaccgactcg gccaccgtct cagccgggcc
    16141 cggaggacgg ggtcaccaga cctcgtcgcc ccgcagcacc gcgtccgcgc ccccgtcgat
    16201 gaacaccacc tgcccggtga cgtgcgtgtt ctccggtgcg gtcaggtgct cgaccagcgg
    16261 cgcgacctgt tcggggtccg cgtagccgtg caggggcatc ggtacggcgc ggtcggcgac
    16321 ggcgcgcatc tcggggttct cgatgatcgc gcggctgagg ggggtgcgga tgatgccggg
    16381 ggcgatgacg ttgaggggga tcccggcgcc cgcccaggcg tcggtgatcg cggcccggcg
    16441 cacccagcgg accagggcgc gcttcgcgga ggcgtacacg agcccgccct cgccgcggtc
    16501 gacggcggcc tgcgcggcgg ccacggcggc gtcctcgtcg tccgcgagga cggcggcgac
    16561 gatcgccggg tccgtctcgt gcacggcggc caccgacgac acggcgagcg cgcgcgggtc
    16621 gcggcccgcg gcgagcagcg gccgcaggcc cgccagcgtg gcgatggcgc cgaagccgtt
    16681 gacccgcacg gtgacggggt cgtacgcgcc gacccccgcg cacgccacca ccgcgtcgag
    16741 ccgcccgccg cccagctcgg cggcggcgtc ggcgagcagg gcccgcccgt cggcggtcgc
    16801 caggtcggcc tggatgtcga cgccgtcggt gtccttgagg tcggcgccga tgacgcggtg
    16861 gccccggccg gtgaggcggc gggcgacggc ccggccgatg ccggacgcgg cgccggtcac
    16921 gaggcagacc cgggcaccgt cccgcccgcc cggccgtgcg tcacgttccg tcgcagtgcc
    16981 cgccatccgt gctccccctc aactcccgta cccagaggcc cgagccaacg taacgccgcc
    17041 ccggcggccc ctgccagacc gcgccgggag cacgggcccg gctccggcgc gcgccggagc
    17101 gagggcgccg ggaccccgtg ccgggccccg gggcgagggc tacgggccgg tacagtgggc
    17161 gggtcgtctc atgcgtgtac gaggggaagc cggtggaagt ccggcgctga ccccgcagcc
    17221 gtgaagccgc gtggcagtcc gccgcggcaa gccggaacgc ctcgtacgcc gcatgaccgg
    17281 ctcgcgtcat cggaacgtgc cgatggccgg caccgtcgag gtatacggag ccggagccgc
    17341 ccggtgcccc tccgtgccgt gctgcccggc cccccgcagg gagaggcacc cgccgcatca
    17401 tgaacgttcg ccgcagcgca gctgccctgg ccgtggccgt cgccgccctc ggcaccgccg
    17461 ccgccccggc cgccttcgcc gacgacgact cgccgtcggc gaaagccacc ggggcgccgc
    17521 tcccgtccgg cctgtacggc aagaaggacc cgcagttcga cggcgtgttc cggcagtcgt
    17581 acgcgctgct cgcgcagaag acggtgggcg tcaccccggc cgcgaaggcc gtggactggc
    17641 tcaccggcca gcagtgcacg agcggcggct tcgcggcgta ccgcgcggac gcgagcgagc
    17701 cgtgcgggtc caagacgcag gtcgactcga actccaccgc cgccgcgatc caggcgctgc
    17761 acgccgtcgg caacgagtcg aacacggtga agaagggcct gggctggctg aagtcggtcc
    17821 agaaccagga cggcggctgg ggctacaacc cgggcctgcc cagcgacgcc aactccaccg
    17881 gcatcgtcgt cggcgccctc gccgccgtcg gcgagaagcc cgcgtccgtg aagtcccaga
    17941 agggcaagtc gccgctcgac gcgctgacga agctcgccat ggactgcggc aaggacggcg
    18001 gcgcgttcgg cctcgccgac gccaagtcgg gcaagctcgc gccgaacgcc gacgcgaccg
    18061 cggccggagt gctcggcggc ctcggccagg gcctcgtgcc cgcgaagggc aagaaggccg
    18121 acgcggcgcc gaagtgcgca aagccggaca cggccaagca ggccgccgac aacggcaccg
    18181 gctatctgct gaagaccctc gccaagaccg gccacctcac ctccgccatg cccggcgcca
    18241 aggaccagcc ggacgtcggc aacaccgccg acgcggtggt cgcgctcgcc gcggcgggcc
    18301 agcaggagca ggcgaagaag tccgccgagt ggctgtcgga gaactccgcc gcctgggcca
    18361 aggacagcgg ccccgccgcc tactcccagc tcgtcttcgc cgccctcgcc gccgacatgg
    18421 acgtacgcga cttcggcggc gccgacctcg tcaagcagct caacgcgcag ggcccgacgc
    18481 cgaaggcgat ctcggagacg accgccgcgg ccaaggagaa ggacgagaag gacgacgacg
    18541 ggtccggcgt cagcgtctgg tggatcgtcg gcgtcggcct ggtcgcgggc gcgggcatcg
    18601 gcttcctgct ctccggccgc aagaagaaga accagctgtg agccggcgcc acccggggcg
    18661 cggccgcctc acggtggccg ccctgctcac cgcgctcctc gccctgcccg ccgcgctcct
    18721 cgccgggagc cccgcccacg ccgccgacta ccgctactgg tcgttctggc agcggggcga
    18781 gggcggcgcg tgggtgtacg cgacgcaggg gccctccatc gcccggcccg acgacggcga
    18841 cgtggagggc ttccggttcg ccgtgtccgc gaactccggc agcgccgaga agccgcgcgg
    18901 cgccgcggac ttcgacacga tctgcgcgga cacgcccgcg cgggacggcc aaaagcgcgt
    18961 cgcgctcgtc atcgacttcg gcacgcggga cgacgccccg ggtggcgagc agcccccgaa
    19021 gcggcgtacg gcgtgcgcgc gcgtcgcctc cgacgggacc agcgccgagg cgctcgccgc
    19081 cgtcgccggg cagctgcgct acaacagctc cgcgctgctc tgcgccatct ccggctaccc
    19141 gaagcagggg tgcggcgagc aggtctccgg caagaagtcg gacgacgcgg gcagcgcccg
    19201 gcaggacggg gacgacggcg gtccctccgt cgggctgctc gccgggatcg cggcgatcgt
    19261 cgcgctcggt gccgccgccg tctggcaggc ccgccgccgc cgtggctgac gcggcccccg
    19321 accggctcct cccgcgccgc ctggcgcccc aggcgcaccg ctccaacgcg ctgcacccgg
    19381 gcgcctggtg gctgtgggcg ctcggcctcg ccacggccgc gtcccgcacc accaacccgc
    19441 tgctcatcgg gctgctcatc ggcgtcgccg ggtacgtcgt cgcggcccgc cgcacgtccg
    19501 cgccctgggc ccgctcctac ggcgcgttcg tgaaactcgc gctcgtcgtc atcggcatcc
    19561 gcctggtctt cgcgatcgtc ctcggctcgc cgatccccgg cacgcacctc atcgtgaccc
    19621 tgccggaagt cccgctgccc gactgggcgc agggcgtgcg catcggcggc cgggtcaccg
    19681 cggagggcgt ggtgttcgcg ctgtacgacg gggtgcgcct cgcgggcctg ctgatctgcg
    19741 tgggcgcggc caacgccctc gccagcccgg cccgcctcct gaagtccctg ccgggggcgc
    19801 tgtacgaggc cggggtggcc gtcgtcgtcg cgatgacgtt cgccccgaac ctgatctccg
    19861 acgtccaacg cctgcgcgcc gcgcgccgcc tgcgcggccg ccccgacaag ggcgtacggg
    19921 gactgctcca ggtgggcctg cccgtcctcg aaggcgccct cgaacggtcc gtcgccctgg
    19981 ccgccgcgat ggacgcgcgc ggcttcggcc gcaccgccgc cgtgcccgcc cgggtgcgca
    20041 ggaccaccgc cgttctgacg ctcggcggcc tgatgggcgt ctgcgcgggg gcgtacgggc
    20101 tgctcaccgc ggacggctcg acgtacggcc tgccggtgct cggcgccggg ctcgccgccg
    20161 cgctcggggg gctctggctc ggcgggcgcc gctcggtgcg gacccgctac cggccggacc
    20221 ggtggggggc gcgggcctgg ctggtcgccg gttcgggggc cgcggtcgcc gccctgatga
    20281 tcgccgcgaa ctccgccgcc gcggacgccc tgcaccccgg ggtgatcccg ctgatcgccc
    20341 ccaccctgcc cctgctgccc gccgcggcgg tcctcatcgg cctgctcccg gcgttcgtgg
    20401 caccggtccc cccgcccgcc gaggcacccg tgcccgcccg cgccacccgc accgcccgta
    20461 ctgccgccga ggagaaggcc tcatgaccat gacccggtcc atgatccggt tcgaggacgt
    20521 ctccgtacgg tacgagggca ccgccgcgcc caccgtgcag ggcgtcgacc tgagcgtccc
    20581 cgagggcgag ctggtgctgc tcgtcggccc ctccggtgtc ggcaagtcga cactgctcgg
    20641 tacggtcagc gggctcgtgc cgcacttcac cggcggcacc ctgcgcggcc gggtgaccgt
    20701 cgcgggccgc gacacccgca cccacaagcc ccgcgaactg gccgacgtgg tcggcacggt
    20761 gggccaggac ccgctcgccc acttcgtgac cgacaccgtc gaggacgagc tggcgtacgg
    20821 catggagtcc ctcggcctcg cccccgacgt catgcgccgc cgcgtcgagg agaccctcga
    20881 cctgctcggc ctcgccgacc tgcgcgaccg ccccatcacc accctctccg gcggccagca
    20941 gcaacgcgtc gccatcggct ccgtcctcac cccgcacccc cgcgtcctcg tcctcgacga
    21001 acccacgtcg gccctcgacc ccgccgccgc cgaggaggtc ctcgccgtcc tccagcgcct
    21061 cgtccacgac ctcggcacca cggtcctgat ggccgagcac cgcctggaac gggtcgtcca
    21121 gtacgccgac caggtcctcc tcctcccggc gccgggcgag ccaccgctcc tcggcgaccc
    21181 ggcggaggtc atggcggtct ccccggtgta cccgccggtg gtggggctcg ggcggctcgc
    21241 gggggtggcg ccgttgccgc tgacggtgcg ggacgcccgg cggcggacgg gtgggctgcg
    21301 ggagcggttg gcggggatgg cgccttcagg ggtggtgcct ccggggggtg agcctgccgg
    21361 ggtggcgcct gccgaggtgg ccgatgaggg gcgtgccgtc gtggctccgg gggctcgtgc
    21421 ggccgaggtg gacgcgcccg ggcgcgtctc gcgttggcgt cgtcacaggg gtaagcgcca
    21481 tgaggccgag gccacgacgc cgggtgccgc gagcccggcg gtcgcgcggc cggaggggac
    21541 ggcgccggcc gccggtacgc ccgccgcacg cgtcgccggg ctcgccgtgc tgcggggccg
    21601 ggtcgaggcc ctgcgccggg tcgacctcgc cgtctccccc ggtgcgaccg tcgccctgat
    21661 gggccgcaac ggcgcgggca agtccaccct cctgtccacc ctggtcggcc tgctgccgcc
    21721 gacgtccgga accgtgcggg tcgggggtgc cgcgccgcac cgcatgccgc cgcgcgagct
    21781 gatccggcac gtcggcctcg taccgcagga gccgcgcgat ctcctgtacg cggacacggt
    21841 gacggcggag tgcgccgccg ccgaccgcga cgcggacgcg gcgccgggca cctgccggga
    21901 cctggtcgcc gatctggtcc ccggcatcgc ggacgacacg cacccccgcg acctgtccga
    21961 gggccagcgc cttgccctcg ccctcgcgat cgtcctgacc acgcgcccgc ccctgctcct
    22021 cctcgacgag cccacccgcg gcctggacta cgcggccaag gcccgcctgg tcacgatcct
    22081 gcgcggcctc gcggcccggg gccacgcgat cgtcctggcc acccacgacg tggaactcgc
    22141 cgccgagctg gcccaccggg tggtgatcct cgccgacggc gaggtggtgg ccgacggccc
    22201 gacggcggac gtcgtggtgt cgtccccgtc gttcgcccca caggtcacca aggtcctcgc
    22261 tccgcagcgg tggctcacgg tgacgcaggt acgggaggca ctggaggcgg ccgatgagta
    22321 gggccccgaa ggagcacggg gcgggtcgtg acgcggctcc gccgcatggg cgcgcccggc
    22381 caccggcgac ccgcggcgga cagccggtcc ggcaggacgg gcaggtccgc cccgtgcggc
    22441 tggggcgacg gtccatcgcc gcgctggccc tggtgagtgc cgtcggagtc gtcgccttcg
    22501 ggtggcccct gctcgccggg tcggactcgg gcctcagcgc gcacgcgaag gacgcaccgt
    22561 ggctgttcgc ggcgctcctg ccgctcctcc tcggcgtggt cgtggcgacg atcgccgacg
    22621 tcggcctgga cgcgaaggcc atcgcgatgc tcggcgtgct ggccgcggcg ggggcggccc
    22681 tgcggccgct gggcgcgggc acggccggga tcgagccgat gttcttcctg atggtgctga
    22741 gcgggcgggt cctcgggccg gggttcggct tcgtgctcgg ggcggtgtcg atgttcgcgt
    22801 cggcgctgct cacgggcggc gtgggc
//
