LOCUS       NZ_BMVR01000001        25556 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000001
VERSION     NZ_BMVR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 923124)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 25556
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25556
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..25556
                     /SMILES="N"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25556
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1737:5556](-)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(1738..5556)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     gene            complement(<1..1525)
                     /locus_tag="IE274_RS00005"
     CDS             complement(<1..1525)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (1-301). E-value:
                     1.2e-108. Score: 354.6. Matches aSDomain:
                     nrpspksdomains_IE274_RS00005_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE274_RS00005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_229909047.1"
                     /sec_met_domain="Condensation (E-value: 4.6e-67, bitscore:
                     221.7, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPLSFAQRRLWFLDRFEGPSAIYNIPFLVRLTGKLDVLALSSAL
                     RDVVVRHESLRTVFVEDADGTPAQRPVPSDELRWEVPVAEVAAGAVPAAVAEAASYVFD
                     LRAEIPVRARLLRCGPQEHVLVLIVHHTAADGESMVPLARDLAAAYTARLDGGDPDWPE
                     LEVQYGDYALWQREFLGDENDPESVLSTQLNYWQGELAGAPQQTQLPLDRPRPAVASHR
                     GGMVEFEVDPALTAAVEKLAGDHGVTTPMVMQSALAVLLHHLGAGDDVAMGSTIAGRND
                     EALADLVGFFVNTWVLRTDLSGNPSLAQVLDRVRDKALGAYDNQDAPFERLVELLNPER
                     STAYHPLFQVMFTWQDDDTVHLGLPGLDARLEAVETQFAKFDLEFGFAADTAGQRMRCV
                     LEYAADLFDRSTIESMGKRFLSILRQFTADPGLLVGSVDVLVADEVVALAGFNETAVVG
                     PELTVPELFGRQVELSPDAVAVVCGGVELTFAELDVRVRGLAGELVRRGV"
     CDS_motif       complement(464..583)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00005_0006"
                     /evalue="3.60E-24"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE274_RS00005"
                     /protein_end="354"
                     /protein_start="314"
                     /score="77.3"
                     /tool="antismash"
                     /translation="RDKALGAYDNQDAPFERLVELLNPERSTAYHPLFQVMFTW"
     aSDomain        complement(623..1522)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS00005_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.20E-108"
                     /label="IE274_RS00005_Condensation_LCL.1"
                     /locus_tag="IE274_RS00005"
                     /protein_end="301"
                     /protein_start="1"
                     /score="354.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHTAADG"
                     /tool="antismash"
                     /translation="IPLSFAQRRLWFLDRFEGPSAIYNIPFLVRLTGKLDVLALSSALR
                     DVVVRHESLRTVFVEDADGTPAQRPVPSDELRWEVPVAEVAAGAVPAAVAEAASYVFDL
                     RAEIPVRARLLRCGPQEHVLVLIVHHTAADGESMVPLARDLAAAYTARLDGGDPDWPEL
                     EVQYGDYALWQREFLGDENDPESVLSTQLNYWQGELAGAPQQTQLPLDRPRPAVASHRG
                     GMVEFEVDPALTAAVEKLAGDHGVTTPMVMQSALAVLLHHLGAGDDVAMGSTIAGRNDE
                     ALADLVGFFVNTWVLRTDL"
     CDS_motif       complement(632..721)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00005_0005"
                     /evalue="3.20E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE274_RS00005"
                     /protein_end="298"
                     /protein_start="268"
                     /score="42.0"
                     /tool="antismash"
                     /translation="DVAMGSTIAGRNDEALADLVGFFVNTWVLR"
     CDS_motif       complement(989..1027)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00005_0004"
                     /evalue="3.60E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE274_RS00005"
                     /protein_end="179"
                     /protein_start="166"
                     /score="19.4"
                     /tool="antismash"
                     /translation="QYGDYALWQREFL"
     CDS_motif       complement(1076..1141)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00005_0003"
                     /evalue="1.90E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE274_RS00005"
                     /protein_end="150"
                     /protein_start="128"
                     /score="23.6"
                     /tool="antismash"
                     /translation="VHHTAADGESMVPLARDLAAAY"
     CDS_motif       complement(1346..1462)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00005_0002"
                     /evalue="6.80E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE274_RS00005"
                     /protein_end="60"
                     /protein_start="21"
                     /score="57.1"
                     /tool="antismash"
                     /translation="AIYNIPFLVRLTGKLDVLALSSALRDVVVRHESLRTVFV"
     CDS_motif       complement(1481..1513)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00005_0001"
                     /evalue="1.40E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE274_RS00005"
                     /protein_end="15"
                     /protein_start="4"
                     /score="11.1"
                     /tool="antismash"
                     /translation="SFAQRRLWFLD"
     misc_feature    1629..1645
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.82"
                     /tool="antismash"
     gene            complement(1738..5556)
                     /locus_tag="IE274_RS00010"
                     /old_locus_tag="GCM10010349_00010"
     CDS             complement(1738..5556)
                     /NRPS_PKS="Domain: CAL_domain (112-552). E-value: 2.1e-66.
                     Score: 215.6. Matches aSDomain:
                     nrpspksdomains_IE274_RS00010_CAL_domain.1"
                     /NRPS_PKS="Domain: PKS_KR (876-1063). E-value: 1.9e-31.
                     Score: 101.4. Matches aSDomain:
                     nrpspksdomains_IE274_RS00010_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (1199-1267). E-value: 5e-22. Score:
                     69.9. Matches aSDomain: nrpspksdomains_IE274_RS00010_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="IE274_RS00010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00010"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_190113436.1"
                     /sec_met_domain="AMP-binding (E-value: 3.9e-78, bitscore:
                     258.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-14, bitscore:
                     50.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAADLLGSAVLDEITAAAKGVPGVGDAIAVARKGVRAVTPTAPA
                     SAPAAPQATGPVEADATDRPLADLDGGPLHIPDGAPATLQEALRAAAELATDKGTIYVT
                     RGNEDVLQTYPELLAEAERVLAGLRAAGLRPGDPALFVFDDNRGYLTTFWACVLGGFVP
                     TPVAVATTYATPNEVNRKLRNAWDLLGRPVLVTDAATAAPLAGVRELWDEPDVRILTVE
                     ELATCPPDSDWFPAKRDSPVLNLLTSGSTGVPKCVQHTNASVVDRSLSAIQYLGLTGDD
                     VSLIWMPFDHVTVVHYNVRDMFLRCMHVNAKISHFLTDPLLWLDWVDRYRVTTTWAPNF
                     AFAMVNELADQHAERSWDLSSLREIINGAEPVIAGTSHRFLELLAPYGLPADAMVPAFG
                     MSETCTAVTYSRQSRDDRAAGTVAIDPASLNTTIRYVDPAADGAVVLSKVGEPIPGVQI
                     RVVDEDGSVLPEGSMGEMRIRGRTMMHGYFANDEANRESFDEDGWFRTGDSAFVTDGEV
                     VIAGRIKDQIIVRGINYMAHELENVVEQIDNVRVTFVGAVGVREPGADSDQLVIFFVPQ
                     NWDPDRLAKTTEEMRAVLVRESGLAPDLLIPVTEAEFPKTGSGKVQRAALANELRAGSF
                     ADRVAGSGAEEQQPEGWFVRRQWAQLPYAGSADDGAGVRLVFGEDEELAHLPLDGQVVT
                     VREGEEYGEDEAGRFRVPSADRAELHRLFKAVTAEHGPLATVVFARPLTRGGDPAARLT
                     DATAELSALLGVLADGAYGQPSVLVLTSGAVHVLDGDRVDLGTCALLGLVRTAVSEAAK
                     LTIRQVDLPADRPGWGDALRAELADRGHSGIVAVRQGKRWQPRLLPTDADDADPGMTGP
                     PVIAGGLYLVTGGLGGIAHDVAAYLVAGYGARLLLVGRSAADGEKADRLSELTGLGEVV
                     YEQLDVADAQALAAAVTSAEERWGRPLDGVLHLAGSDPTAQWAESDAHTVVNETMATYA
                     EQYSAKVDGTLAIATVLETRQDASLVLFGSVTAEFGGHSFGAYAAANSFLSGFADYWHH
                     ERRRTVRYLAWSMWTGIGMNRGQSTAAARSRGFRIIEPAGGLQLFLDTLTMPHHSLIIG
                     LDLANPAMVEELMPDQLRVSEVVLAYTGDGVDQAAVREAVAASVRDCPVPVRLIETPLI
                     PRDATGAADVAQLLLEAVPGRVKRAVEAPATDLERQLAAIWSEALNRPVLGRDESFFEL
                     GGNSLRATRLLAMVDQDLAVRVTTQELFENPTVAGMAESVLRHGPGT"
     aSDomain        complement(1756..1959)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS00010_PCP.1"
                     /evalue="5.00E-22"
                     /label="IE274_RS00010_PCP.1"
                     /locus_tag="IE274_RS00010"
                     /protein_end="1267"
                     /protein_start="1199"
                     /score="69.9"
                     /tool="antismash"
                     /translation="ERQLAAIWSEALNRPVLGRDESFFELGGNSLRATRLLAMVDQDLA
                     VRVTTQELFENPTVAGMAESVLR"
     aSModule        complement(1756..5220)
                     /complete
                     /domains="nrpspksdomains_IE274_RS00010_CAL_domain.1"
                     /domains="nrpspksdomains_IE274_RS00010_PKS_KR.1"
                     /domains="nrpspksdomains_IE274_RS00010_PCP.1"
                     /locus_tags="IE274_RS00010"
                     /monomer_pairings="NH2 -> NH2"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(2368..2928)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS00010_PKS_KR.1"
                     /evalue="1.90E-31"
                     /label="IE274_RS00010_PKS_KR.1"
                     /locus_tag="IE274_RS00010"
                     /protein_end="1063"
                     /protein_start="876"
                     /score="101.4"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GLYLVTGGLGGIAHDVAAYLVAGYGARLLLVGRSAADGEKADRLS
                     ELTGLGEVVYEQLDVADAQALAAAVTSAEERWGRPLDGVLHLAGSDPTAQWAESDAHTV
                     VNETMATYAEQYSAKVDGTLAIATVLETRQDASLVLFGSVTAEFGGHSFGAYAAANSFL
                     SGFADYWHHERRRTVRYLAWSMWT"
     CDS_motif       complement(2416..2514)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00010_0005"
                     /evalue="3.60E-09"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE274_RS00010"
                     /protein_end="1047"
                     /protein_start="1014"
                     /score="29.1"
                     /tool="antismash"
                     /translation="VLFGSVTAEFGGHSFGAYAAANSFLSGFADYWH"
     CDS_motif       complement(2827..2922)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00010_0004"
                     /evalue="1.70E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE274_RS00010"
                     /protein_end="910"
                     /protein_start="878"
                     /score="23.9"
                     /tool="antismash"
                     /translation="YLVTGGLGGIAHDVAAYLVAGYGARLLLVGRS"
     aSDomain        complement(3901..5220)
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS00010_CAL_domain.1"
                     /evalue="2.10E-66"
                     /label="IE274_RS00010_CAL_domain.1"
                     /locus_tag="IE274_RS00010"
                     /protein_end="552"
                     /protein_start="112"
                     /score="215.6"
                     /specificity="Minowa: NH2"
                     /tool="antismash"
                     /translation="TYPELLAEAERVLAGLRAAGLRPGDPALFVFDDNRGYLTTFWACV
                     LGGFVPTPVAVATTYATPNEVNRKLRNAWDLLGRPVLVTDAATAAPLAGVRELWDEPDV
                     RILTVEELATCPPDSDWFPAKRDSPVLNLLTSGSTGVPKCVQHTNASVVDRSLSAIQYL
                     GLTGDDVSLIWMPFDHVTVVHYNVRDMFLRCMHVNAKISHFLTDPLLWLDWVDRYRVTT
                     TWAPNFAFAMVNELADQHAERSWDLSSLREIINGAEPVIAGTSHRFLELLAPYGLPADA
                     MVPAFGMSETCTAVTYSRQSRDDRAAGTVAIDPASLNTTIRYVDPAADGAVVLSKVGEP
                     IPGVQIRVVDEDGSVLPEGSMGEMRIRGRTMMHGYFANDEANRESFDEDGWFRTGDSAF
                     VTDGEVVIAGRIKDQIIVRGINYMAHELENVVEQIDNVRVT"
     CDS_motif       complement(3937..3999)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00010_0003"
                     /evalue="1.70E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="IE274_RS00010"
                     /protein_end="540"
                     /protein_start="519"
                     /score="11.2"
                     /tool="antismash"
                     /translation="AGRIKDQIIVRGINYMAHELE"
     CDS_motif       complement(4063..4152)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00010_0002"
                     /evalue="9.30E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS00010"
                     /protein_end="498"
                     /protein_start="468"
                     /score="11.7"
                     /tool="antismash"
                     /translation="PEGSMGEMRIRGRTMMHGYFANDEANRESF"
     CDS_motif       complement(4777..4824)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00010_0001"
                     /evalue="3.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS00010"
                     /protein_end="260"
                     /protein_start="244"
                     /score="13.8"
                     /tool="antismash"
                     /translation="LLTSGSTGVPKCVQHT"
     gene            complement(5553..6335)
                     /locus_tag="IE274_RS00015"
                     /old_locus_tag="GCM10010349_00020"
     CDS             complement(5553..6335)
                     /NRPS_PKS="Domain: Thioesterase (25-248). E-value: 3.5e-44.
                     Score: 143.9. Matches aSDomain:
                     nrpspksdomains_IE274_RS00015_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719712.1"
                     /locus_tag="IE274_RS00015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00020"
                     /product="thioesterase II family protein"
                     /protein_id="WP_190113437.1"
                     /sec_met_domain="Thioesterase (E-value: 7.5e-43, bitscore:
                     142.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQTRELVPETPYIWRAKQPGHTHRLICFPHAGAGAAAYADWVR
                     WLPPEIELVAVQLPGRQNRIAEQPFTEVGPLVNALTHALRPVMDGSFSFFGHSCGAALA
                     YELTTALRARGRRGPEQLFLSGRAAPDVTGIRQLHELSDEEFSNAVLELGGIDPEIAAD
                     EFVMSVLLEVLRADFGLWERHQVKSEEPLDCLITALGSDADPQAPLHSVRRWRQHTNAQ
                     FSERIYAGGHFYFLEKAAEVVSFIGSKMLESARSGSAA"
     aSDomain        complement(5592..6260)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS00015_Thioesterase.1"
                     /evalue="3.50E-44"
                     /label="IE274_RS00015_Thioesterase.1"
                     /locus_tag="IE274_RS00015"
                     /protein_end="248"
                     /protein_start="25"
                     /score="143.9"
                     /tool="antismash"
                     /translation="RLICFPHAGAGAAAYADWVRWLPPEIELVAVQLPGRQNRIAEQPF
                     TEVGPLVNALTHALRPVMDGSFSFFGHSCGAALAYELTTALRARGRRGPEQLFLSGRAA
                     PDVTGIRQLHELSDEEFSNAVLELGGIDPEIAADEFVMSVLLEVLRADFGLWERHQVKS
                     EEPLDCLITALGSDADPQAPLHSVRRWRQHTNAQFSERIYAGGHFYFLEKAAEVVSFIG
                     S"
     CDS_motif       complement(6003..6071)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS00015_0001"
                     /evalue="6.80E-05"
                     /label="NRPS-te1"
                     /locus_tag="IE274_RS00015"
                     /protein_end="111"
                     /protein_start="88"
                     /score="15.4"
                     /tool="antismash"
                     /translation="DGSFSFFGHSCGAALAYELTTAL"
     misc_feature    6361..6378
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    6414..6426
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(6463..6478)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.79"
                     /tool="antismash"
     gene            6784..7527
                     /locus_tag="IE274_RS00020"
                     /old_locus_tag="GCM10010349_00040"
     CDS             6784..7527
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="IE274_RS00020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00040"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_198898057.1"
                     /transl_table=11
                     /translation="MDIQDGGLAVPLDGAKQRTVLAALLIAEGSLVSDTELSRLLWGEQ
                     PPATHGAQIYNHVSRLRKTLGSEVSITRCSPGYLMEIGDDSFDLREFENLAMRGQSALL
                     AGRFEEASQPLHLALSLWRGPALADVSEALALTEGPRIEERRISVVESRIEADLAIGKH
                     AEVLPELTRLVEQYPLRERFRAQLMTTLYRCDRQAEALVLYDWSRKMLVEELGVEPGAL
                     LRQVHHAILTADPSLHSPFGLQLAR"
     gene            complement(7532..8074)
                     /locus_tag="IE274_RS00025"
                     /old_locus_tag="GCM10010349_00050"
     CDS             complement(7532..8074)
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004001188.1"
                     /locus_tag="IE274_RS00025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00050"
                     /product="flavin reductase family protein"
                     /protein_id="WP_190113439.1"
                     /transl_table=11
                     /translation="MTDLSITRPVEASASEGLRAMMRGFPTGVAVVTGVDLDGQPWGLT
                     CSSVCSVSLDPPTLLVCLRAGSPTLAAIEARGAFSVNLLHEDARATAELFASGDPDRFE
                     RVRWEQDVDAAGPHLPDDAHAIADCRVAMTQSVGDHVVVFGEATRVHGQDACRPLLYGL
                     RSYGRWSPADVSAGQRA"
     gene            complement(8071..9342)
                     /locus_tag="IE274_RS00030"
                     /old_locus_tag="GCM10010349_00060"
     CDS             complement(8071..9342)
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013188.5"
                     /locus_tag="IE274_RS00030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00060"
                     /product="cation:proton antiporter"
                     /protein_id="WP_190113440.1"
                     /transl_table=11
                     /translation="MTDFLLTGVHVAAALAVVLVIGYAGRSAARLLRQPETVGEIVAGL
                     LAGPAAVALLGRSKFDAVLPGDVLDIMKLVAEVGLVLFLVGLAHKLRLGAHRSSLRTSA
                     WLVAGGLVPAMFSGVLFAGWILLSDDPDVRGSAPLPAFVLMCAVALSITAVPVLARILA
                     ERNATDTLEGRLSMTAAVVIDTVGWLLLSVAVGLSTGELNGFVQSVVVLGGGAAAALGV
                     RSALRTRAAHNLCEQRPLVTAVLLGAIALTMALTVERLGLTAIFGAVLVGLALPPDGPW
                     QQVANRVTNLGRGMIPFFFVVTGVTVFAGGIGPLPWALTAGAILLAVLGKGMGSYFGTR
                     MAGQPKQTAVTVGILMNTRGLTELIVLKVGYNADILTRPVFVALIVMAVATTVMTGPLL
                     LLTKWSPGQPVRTSVGSKSQDDSP"
     gene            complement(9339..10910)
                     /locus_tag="IE274_RS00035"
                     /old_locus_tag="GCM10010349_00070"
     CDS             complement(9339..10910)
                     /EC_number="1.14.19.-"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (halogenases)
                     flavin-dependent trp 6 7 halogenase"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000030: Halogenation (74% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119: halogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004259.1"
                     /locus_tag="IE274_RS00035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00070"
                     /product="tryptophan halogenase family protein"
                     /protein_id="WP_190113441.1"
                     /sec_met_domain="Trp_halogenase (E-value: 7.1e-145,
                     bitscore: 478.8, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.2e-09, bitscore: 33.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTKNPDRVVIVGGGTAGWMTASYLKKAFGDKISVTLVESGKIGT
                     IGVGEATFSDIRHFFEFLDLKEEEWMPACNATYKLAVRFQDWRRKGHHFYHPFEQMPTV
                     NGFPLTDWWLQDGPTDRFDTDCFVMANLCDAGRSPRFLDGSLIDQGFAEGAKELSGLTM
                     SEHQGKTQFPYAYHFEAALLAKYLTKYSTDRGVHHIIDEVQDVRLDERGWIDHIVTKDH
                     GSLEGDLFVDCTGFRGVLLNKALEVPFISYQDTLPNDSAVALQVPLDMEKRGINPYTQA
                     TAQDAGWIWTIPLFGRIGTGYVYAKDYLSPEEAERTLREFVGPEAAEVEANHIRMRIGR
                     SEQSWKNNCVAIGLASGFVEPLESTGIFFIHHAIEQMVKHFPAADWSPELRKSYNSSIA
                     NVMDGVREFLVLHYQGAGRDDTQYWKDTKTRAVPDGLAERLERWKVQLPDSENVFPYYH
                     GLPPYSYMCILLGTGAIPARATPSLGMSDTAAAHKEFAAIRDKSRHLIETLPSTYEYFA
                     SMRERS"
     misc_feature    complement(10964..10978)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(11143..13482)
                     /locus_tag="IE274_RS00040"
                     /old_locus_tag="GCM10010349_00080"
     CDS             complement(11143..13482)
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740895.1"
                     /locus_tag="IE274_RS00040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00080"
                     /product="DPP IV N-terminal domain-containing protein"
                     /protein_id="WP_372447297.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 5.1e-41, bitscore:
                     136.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPGPDCTATTSKEGQPMHATRLDGRVYETAERLLRHNRRDLVLG
                     TNIRPRWIEDGSRFWYTVGTPEGKRFIQVDTKAGVRDVAFDHKRLAGALAKESGQEVDA
                     AALPFFAVELTTGAVEFDAFGEHWRVSLDDYACRKTEGAPPGNPLEVPSPDRKFAVYRA
                     GHDLRARSLDGSRDWALTSDGTEDVDYGASPDYLMYSTLLAKVGLPHLPPCVAWSPDGT
                     RLLTHRTDNRGVRRTHLVDSAPAAGGEPRLLSQRYPHPGDDSSTVAEFVVIDIENGTVV
                     TAQADPVGMSVMSPIFRRWAWWAEDGSAVYYLGWGQEGVHTLSLYRLDPESGEVRTVVS
                     ETGETRVEPAQRELQQPMVRLLSGGRELLWYSQRDGWGHLYLYGTDSGELRGQVTSGPW
                     AVQEILRVDEERRVVHFIASGLVEEDPYRRTVCRVNLDGTGFAKVTDDAFDHVVTVAEN
                     GEFFIDSASTTDTPPTATVRDWDGKALVELERADITRLTACGWSAPERFRATGADGETE
                     IYGLLYRPHGFDPSRRYPVIDHPHALPMDNRVSPSFDPGWYGYEAEALAALGFVVIAVD
                     GAGTPGRGKEFHDATYGKLAAGLADHVSAVRELAATRPWMDLDRVGATGTSAGGFAALR
                     ALLDFPELFKVGVAESGMHDFRYLDKEHAEAYHGPFDEAAYAATSNVDIADRLEGKLLL
                     LHGGLDDRVSPDLTLRLADALIAADKDFDLVIVPGADHMYFGYEHYVNRRKWDFLVRHL
                     LGVEPPADYRLSPVPMDMEALAELFG"
     gene            complement(13723..14520)
                     /locus_tag="IE274_RS00045"
                     /old_locus_tag="GCM10010349_00090"
     CDS             complement(13723..14520)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645013.1"
                     /locus_tag="IE274_RS00045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00090"
                     /product="ABC transporter permease"
                     /protein_id="WP_190113443.1"
                     /transl_table=11
                     /translation="MSTSAYAVRDSMTMLRRNLKHMYRYPTITLSVAAMPVVMLLLFVY
                     VFGGAIGNGLGLPGASNDRGEYTNFVVPGIILMAVTSGGVTTAVSVCTDMTEGIINRFR
                     TMAISRASVLVGHVVGSVIQTMISLVFVLGLAFVVGFRPDASPIEWLAAIGLLVLLAFA
                     VTWLSAAMGMGAKTIETASNAPTPLTFLPFLGSAVVTPDSMPVGLRWFAEYQPFTPINE
                     TLRGLMLGTEIGNDGLKAIAWCLGLIVVGYLWARAVFNRETTR"
     gene            complement(14517..15515)
                     /locus_tag="IE274_RS00050"
                     /old_locus_tag="GCM10010349_00100"
     CDS             complement(14517..15515)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645012.1"
                     /locus_tag="IE274_RS00050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00100"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_190113444.1"
                     /transl_table=11
                     /translation="MTATAHMAGQPKGISALGLRKAYGEKVVLDGVDLEVPAGTVFSLL
                     GPNGAGKTTTVQILSTLISADAGQAQVAGHVLDREPDAVRAEIGVTGQFSAVDNLLTAR
                     ENIILMADLHHLPRNEGKQRAAALLERFDLTEVADKPAITFSGGMRRKLDLAMTLVGRP
                     SIIFLDEPTTGLDPRSRRNLWQIIHDLVAEGTTIFLTTQYLEEADQLADRIAVLDGGKI
                     VAEGTAAELKRRIPGGHIRLQFADVHRLDVAARALGQALRDDEALTLQVPNDGSIPALR
                     TVLDRLDAAQIEAEALTVHTPDLDDVFLALTGNQVPGQVSDNTELAKESLR"
     ncRNA           complement(16316..16727)
                     /db_xref="RFAM:RF00010"
                     /gene="rnpB"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00010"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="IE274_RS00055"
                     /ncRNA_class="RNase_P_RNA"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="RNase P RNA component class A"
     gene            complement(16316..16727)
                     /gene="rnpB"
                     /locus_tag="IE274_RS00055"
     misc_feature    16611..16623
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(<16798..17628)
                     /locus_tag="IE274_RS40275"
                     /old_locus_tag="GCM10010349_00110"
                     /pseudo=""
     CDS             complement(<16798..17628)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013088.5"
                     /locus_tag="IE274_RS40275"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00110"
                     /product="DMT family transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTARGWLLFSFMGVLWGIPYLMIKVAVDSDLTPSMVVFTRCALGA
                     ALLLPFAMRQGGMPAVLRTHWRPMLAFAAVEILGPWWTLTDAERHLSSSTAGLLIAAVP
                     IIGALLARFFGDTERLGPRRVTGLALGFAGVAVLTVPHLTGGDAWSLTEVLLTALGYAI
                     APLIVARHLKDVPTLQLIAPCLTLAALVYAPAAAATWPDTLPDGKTLAALAGLGVICTA
                     LAFIVFLELIREAGPTRAVVFTYINPAVAAAAGFAFLDESLTAAFAAAFTLILAG"
     gene            complement(17656..18624)
                     /locus_tag="IE274_RS00065"
                     /old_locus_tag="GCM10010349_00120"
     CDS             complement(17656..18624)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642888.1"
                     /locus_tag="IE274_RS00065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00120"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_190113445.1"
                     /transl_table=11
                     /translation="MAHTKQAFTPADRAIWTRAPLGTDTTLDLLTARFDRHRYAPHYHE
                     EFTVGVCVGGSEIIDYRGGRLDVGPGAVVVLAPGETHTGRPGPGGGYAYRAMYPAVHLF
                     ADGARALPHFRQAVLDDPQLAAALRAAHTGLSRAPARGAEILDPAADVPDLLTALAAET
                     RLTELFAALARRHAEARPLRAGDRGREGTAVPGTTAIARTVRDRLADSVLAPPTLTELA
                     TELGLSRYQLLRAFRTTTGMPPYAWLAQYRVGRARGLLERGLRPAAVAGLVGFADQAHL
                     TRWFRRVVGVTPAAYRDSVRAATAPTRRDEAGPATATTFKT"
     gene            18872..19681
                     /locus_tag="IE274_RS00070"
                     /old_locus_tag="GCM10010349_00130"
     CDS             18872..19681
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642890.1"
                     /locus_tag="IE274_RS00070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00130"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_190113446.1"
                     /transl_table=11
                     /translation="MRIGEIAAAVGLTTRAIRHYHHLGLLPEPARRPNGYREYGLREAI
                     LLARVRRLTELGLGLDEVRDVLADDVGRELTEVLAELDDDLARQEADIRARRERLAELL
                     QMSREGLLPGEGPVSPGLAELFGRFSPAESATAAKDLEHLALFDATADPDRRDRIYQAL
                     SELADDPELAARLRELYARMDDIADASPDDPRVEPLGKDLAAIVPDDLLAALVHGGEGR
                     EDGSPARTDPGPGSAFGEAFLDDFAPAQAAAVREMLTVLTGRTGWTP"
     gene            19678..20382
                     /locus_tag="IE274_RS00075"
                     /old_locus_tag="GCM10010349_00140"
     CDS             19678..20382
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010057609.1"
                     /locus_tag="IE274_RS00075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00140"
                     /product="hypothetical protein"
                     /protein_id="WP_190113447.1"
                     /transl_table=11
                     /translation="MTRLVRVVRRLAAHELRGFHSLALWVARRRHGVGAGARPAAYTGP
                     QTALLFGFAFVAVVETVVLALIVPWPLVHAALLFVDVYTVLQIVALHAASVTRPHVVGV
                     DGSLRVRYGQFVDLRIPAADMARVRVERRYPEGRTVQIHADGVVDIAVGSQTTVTVELA
                     RPVAFVRPLGLPARARVVRLHADDPRALVDALARTRTEEAGRTRPGDRTPTASHPLTPE
                     RTAPSPVPDQPA"
     gene            complement(20333..21793)
                     /locus_tag="IE274_RS00080"
                     /old_locus_tag="GCM10010349_00150"
     CDS             complement(20333..21793)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239016.1"
                     /locus_tag="IE274_RS00080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00150"
                     /product="RNB domain-containing ribonuclease"
                     /protein_id="WP_190113448.1"
                     /transl_table=11
                     /translation="MPRRHLHVTGAAEAPLRAALRALRAELDVPEAFAADVLAEAERAA
                     AAPRLPAEDATGVPFFTVDPPTSVDLDQAMHLSRRAGGGFRVRYAIADVAAYVTPGGPL
                     DATAHRRVTTLYFPDGKVPLHPTPLSEGAASLLPDQTCPAVLWTLDLDAEGRTARTDVR
                     RALVRSRAKLDYEGVQRAIDAGTAEEPVALLADIGRLREQREAERGGISLNVPEQEVTE
                     QDGTYALGFRAPLPADGWNAQISLLTGMAAADLMIASGTGVLRTLPLAPDGAVTRLRHT
                     AKALGIDWPHHVPYAGLVRSLDPRDPHHAAFLQECTTLLRGAGYTAFSGGEVPELTTHA
                     AVAAPYAHCTAPLRRLVDRYAAELCLAACAGAEPPDWVLAALPELPREMADGTRRANAV
                     ERGCVDIVEAALLKDRVGEVFDGVVVDVKEREPGVGTVQLAEPAVVARIEAGPGGAGGS
                     AGLPLGERLRVRLTQADPGRAKVLFAPA"
     gene            21952..22752
                     /gene="yaaA"
                     /locus_tag="IE274_RS00085"
                     /old_locus_tag="GCM10010349_00160"
     CDS             21952..22752
                     /codon_start=1
                     /gene="yaaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969487.1"
                     /locus_tag="IE274_RS00085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00160"
                     /product="peroxide stress protein YaaA"
                     /protein_id="WP_190113449.1"
                     /transl_table=11
                     /translation="MLVLLPPSEGKAPSGRGAPLKPESLSLPGLADARAAVLDELVELC
                     VADEDKACAVLGLSEGLRGEVGKNAELRTAGARPAGEIYTGVLYDALGLASLDAAAKRR
                     AARSLLVFSGLWGAVRVTDRIPSYRCSMGVKLPALGALGAHWRGPMAAVLPEAAGDGLV
                     LDLRSSAYTSAWKPKGEVAGRTATVRVLHSQVVDGVERRSVVSHFNKATKGRLVRGLLT
                     AGISPAGPAELVSALRDLGYVVEAEAPSRAGRAWALDVVVREIH"
     gene            22849..23484
                     /gene="eda"
                     /locus_tag="IE274_RS00090"
                     /old_locus_tag="GCM10010349_00170"
     CDS             22849..23484
                     /EC_number="4.1.2.14"
                     /EC_number="4.1.3.16"
                     /GO_function="GO:0008675 -
                     2-dehydro-3-deoxy-phosphogluconate aldolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008700 - 4-hydroxy-2-oxoglutarate
                     aldolase activity [Evidence IEA]"
                     /GO_process="GO:0009255 - Entner-Doudoroff pathway through
                     6-phosphogluconate [Evidence IEA]"
                     /codon_start=1
                     /gene="eda"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642895.1"
                     /locus_tag="IE274_RS00090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00170"
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="WP_190113450.1"
                     /transl_table=11
                     /translation="MNPAAAAKASVLDLAPVVPVVVIDDPADALPLARALVAGGLPAIE
                     VTLRTPVALDAIRVIADGVPDAVVGAGTVISAGNVEDAVDAGARFLVSPGWTPTLLAAM
                     KASGVPFLPGVSTTSEVVALLEHGVEEMKFFPAQAAGGTPYLKSLAGPLPQARFCPTGG
                     ISAASAPDYLALRNVGCVGGSWMLPADAVAAKDWARVESLARAAAALR"
     gene            complement(23531..24937)
                     /locus_tag="IE274_RS00095"
                     /old_locus_tag="GCM10010349_00180"
     CDS             complement(23531..24937)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478610.1"
                     /locus_tag="IE274_RS00095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_00180"
                     /product="bifunctional RNase H/acid phosphatase"
                     /protein_id="WP_190113451.1"
                     /transl_table=11
                     /translation="MREFIVEADGGSRGNPGPAGYGAVVIDAASGETLAEAAEYIGVAT
                     NNVAEYKGLVAGLKAARALDPAASVHVRMDSKLVVEQMSGRWKIKHPDMKPLAAEAARV
                     LPGTQVTYEWIPREQNKHADRLANEAMDAGKRGEQWSPSASTAELDRPVRTAGAGAPAG
                     PPGDAAAGAAKARAALAGAAAGRGAEAGGGGFTAGSLGDATAGAQGSAGVADVADVRAA
                     RSVAAGSGAGAAASGAGAVAAADVPGTAVPPVGWGAAADLGAPATFVLLRHGETPLTPQ
                     KRFSGSGGSNPSLSDAGREQAVRVAAALAARGTVQAVVSSPLLRCQETARTVAARLGLD
                     VHLEEGLRETDFGDWEGLTFAEVRERQPDELTAWLASPDVAPPGGESFAEVSTRVEAAR
                     EKLLAAYAGRTVLLVTHVTPIKTLVRLALGAPPESLFRMELSAASLSAVAYYTDGNASV
                     RLLNDTAHLR"
ORIGIN
        1 ccacaccacg ccggaccaac tcacccgcca gcccacgcac ccgcacatca agctcagcga
       61 acgtcagctc cacaccacca cacaccaccg ccaccgcatc cggcgacaac tccacctgcc
      121 gcccgaacaa ctccggaacc gtcaactccg gccccaccac agccgtctca ttgaacccag
      181 ccagcgccac cacctcatcc gccaccaaca catccaccga acccaccaac aaccccgggt
      241 cggcggtgaa ctggcgcagg atggagagga aacgcttccc catggactcg atggtggagc
      301 ggtcgaacag gtcggccgcg tactccagga cgcatcgcat ccgctgcccc gcggtatccg
      361 cggcgaagcc gaactcgagg tcgaacttgg cgaactgcgt ctccaccgcc tcaaggcggg
      421 cgtccagccc gggcaggccg aggtgcaccg tgtcgtcgtc ctgccaggtg aacatcacct
      481 ggaacagcgg gtggtacgcc gtggagcgct ccgggttgag cagctcaacc aggcgctcga
      541 acggggcgtc ctggttgtcg taggcaccca gggccttgtc ccgcacccgg tcaaggacct
      601 gcgccagtga cggattgccg gacaggtcgg tccgcagcac ccaggtgttg acgaagaatc
      661 ccaccaggtc cgcgagcgcc tcgtcgttgc gccccgcgat cgtggacccc atggccacgt
      721 cgtcgccggc tcccaggtgg tgcagcagca cggccagcgc cgactgcatg accatcggcg
      781 tggtcacacc gtggtcgccg gccagcttct ccaccgcggc cgtgagggcg gggtcgacct
      841 cgaactcgac catgccgccg cggtggctcg ccacggccgg ccgggggcga tcgaggggca
      901 gctgcgtctg ctgcggcgcc cccgccaact cgccctgcca gtagttcagt tgggtggaca
      961 gcacactttc ggggtcgttc tcgtcgccga ggaactcccg ctgccacagg gcatagtcgc
     1021 cgtactggac ctcgagctcc ggccagtccg ggtccccgcc gtccaggcgc gccgtgtagg
     1081 cggcggccag gtcgcgggcc agcggcacca tcgactcacc gtccgccgcg gtgtgatgca
     1141 cgatcagcac cagcacgtgc tcctgggggc cgcagcgaag cagtcgggcc cgtacgggaa
     1201 tctcggcgcg cagatcgaag acgtaggacg ccgcctcggc caccgcggcg gggacggcgc
     1261 cggcagccac ctcggccacc ggcacctccc accgcagttc gtcggacggc acggggcgct
     1321 gcgcgggcgt gccgtccgcg tcctcgacga agaccgtgcg caggctctcg tgccggacga
     1381 cgacgtcacg cagcgccgag gacagggcga gcacatccag cttccccgtc agccgcacca
     1441 ggaacgggat gttgtagatc gccgacggtc cctcgaaccg gtcgaggaac caaagccgcc
     1501 gctgggcaaa ggacaggggg atcatttcgc gactactcct cgatcagtcg tccggcggaa
     1561 gcggacgaat cacatcgcgc tgcgttcgaa tcttcgtttt atgggggctg aacggaaatc
     1621 ccgttcaccg aagcagaact gggcagcaat atgcccagcg cgacgctctc ccccgaatac
     1681 ttccgatgct tcatccctgc accgcacagc gtcaagctgt ttatgtggcg ccgtggttca
     1741 cgttcccggt ccgtgccgca ggacggattc cgccatcccg gccacggtgg gattctcaaa
     1801 gagttcctgc gtggtgaccc gtacggccag atcctggtcg accatcgcca ggagccgggt
     1861 cgcgcgcaac gaattgccgc cgagttcgaa gaacgactcg tcccggccga ggaccgggcg
     1921 gttgagggcc tccgaccaga tggcggcgag ctgccgctcc aggtccgtgg ccggcgcctc
     1981 cactgcgcgc ttcaccctgc cgggaacggc ttccagcagc aactgggcga cgtcggcggc
     2041 gcccgtggcg tcccgtggga tgagcggcgt ctcgatcagc cgtaccggca ccggacagtc
     2101 gcggacgctc gcggcgacgg cctcccggac agctgcctgg tcgacgccgt cccctgtata
     2161 ggcgaggacg acttcgctga cccggagctg atccggcatc aattcctcga ccatcgccgg
     2221 gttcgcgaga tcgaggccga tgatcagaga gtggtggggc atggtgagcg tgtcaaggaa
     2281 caactgcagt cccccggcgg gctcgatgat acggaatcca cgactgcgcg ccgccgcggt
     2341 cgactgaccg cggttcatcc cgattccggt ccacatgctc caggcgagat accgaaccgt
     2401 gcggcggcgc tcatggtgcc agtaatcggc gaacccggaa aggaaactgt tcgccgcggc
     2461 ataggcgccg aacgaatggc caccgaattc cgccgtgacc gaaccgaaga gcacgagcga
     2521 cgcgtcctgc cgggtttcga gcacggtcgc gatggccagg gtgccgtcga ccttcgcact
     2581 gtactgctcg gcgtaggtcg ccatggtctc gttgaccacg gtgtgcgcat cggactcggc
     2641 ccactgggcg gtcgggtccg agcccgccag atgcagcacg ccgtcgagcg gacggcccca
     2701 gcgctcctcc gccgacgtca ccgccgccgc cagtgcctgc gcgtcggcga cgtcgagctg
     2761 ttcgtagacg acctcgccga gtccggtcag ctcggacagc cggtcggcct tctcgccgtc
     2821 cgcggccgaa cggcccacga gcagcaggcg ggcgccgtac ccggcgacga ggtaggcggc
     2881 cacgtcgtgc gcgatgccgc ccaggccgcc ggtgaccaga tagagaccgc ccgcgatcac
     2941 gggcggaccc gtcatgcccg ggtcggcgtc gtcggcgtcg gtcggcagca gccgcggctg
     3001 ccaccgcttg ccctgccgta cggcgacgat cccgctgtgg ccccggtcgg cgagctcggc
     3061 acggagtgcg tccccccagc cggggcggtc cgcgggcagg tcgacctgcc tgatcgtcag
     3121 cttcgcggcc tcgctgaccg cggtccgcac gaggccgagc agggcgcagg tgccgaggtc
     3181 gacgcggtcg ccgtccagga cgtgcaccgc ccccgaggtc aggacgagca ccgacggctg
     3241 gccgtacgcg ccgtccgcga gcaccccgag cagcgcggac agttccgcgg tcgcgtcggt
     3301 gagccgggcg gcggggtcgc ctccgcgcgt cagcggccgg gcgaacacca ccgtggcgag
     3361 cggaccgtgc tcggcggtga cggccttgaa cagccggtgc agttcggctc ggtcggccga
     3421 cgggacccgg aacctgcccg cctcgtcctc gccgtactcc tcgccctcgc ggacggtgac
     3481 gacctgcccg tcgagcggga ggtgcgccag ctcctcgtcc tcgccgaaga cgaggcgcac
     3541 cccggctccg tcgtcggcgg acccggcgta ggggagctgc gcccactgcc gccggacgaa
     3601 ccagccctcc ggctgctgct cctccgcgcc ggatccggcc acgcggtcgg cgaaggagcc
     3661 cgcacgcagt tcgttggcca gggccgcccg ctggaccttc ccgctgcccg tcttcgggaa
     3721 ctcggcctcg gtgaccggga tgagcaggtc cggagcgagt ccggactcgc gcaccaggac
     3781 ggcgcgcatc tcttccgtgg tcttggccag gcggtccggg tcccagttct gcggtacgaa
     3841 gaagatcacc agctggtcgc tgtcggcacc cggctcccgc acgccgaccg cgccgacgaa
     3901 ggtgacccgt acgttgtcga tctgttcgac gacgttctcc agctcgtgcg ccatgtagtt
     3961 gatgccgcgc acgatgatct ggtccttgat ccgccccgcg atcacgacct cgccgtccgt
     4021 cacgaacgcg gagtcgccgg tgcggaacca gccgtcctcg tcgaacgact cacggttggc
     4081 ctcgtcgttg gcgaagtagc cgtgcatcat cgtgcggccg cggatgcgca tctcccccat
     4141 gctgccttcg ggcagcaccg agccgtcctc gtccacgacg cggatctgga ccccggggat
     4201 cggctctccg accttggaga ggacgacggc cccgtccgcc gccggatcga cgtagcggat
     4261 ggtcgtgttg agcgaggccg ggtcgatggc gacggtgccg gcggcccggt cgtcccggct
     4321 ctgccggctg taggtcacgg cggtgcacgt ctcggacatg ccgaacgccg ggaccatggc
     4381 gtcggcgggc agcccgtagg gagcgagcag ctccaggaag cgatggctcg tgcccgcgat
     4441 caccggctcg gcgccgttga tgatctcgcg caacgaggag aggtcccagg agcgttcggc
     4501 gtgctggtcg gcgagttcgt tgaccatggc gaacgcgaag ttcggggccc aggtggtggt
     4561 cacccggtac cggtcgaccc agtccagcca gagcagcggg tcggtgagga agtgggagat
     4621 cttggcgttg acgtgcatgc agcgcaggaa catgtcacgg acgttgtagt gcacgaccgt
     4681 gacgtggtcg aacggcatcc agatcaggct cacgtcgtca ccggtgaggc cgaggtactg
     4741 gatggcggac agcgaacggt ccaccacgct cgcgttggtg tgctgcacgc acttgggcac
     4801 gccggtgctg ccggaggtga gcaggttgag caccggagag tcccgcttcg ccgggaacca
     4861 gtcgctgtcc ggcgggcacg tggccagctc ctcgacggtg aggatccgta cgtccggctc
     4921 gtcccagagt tcccgcaccc cggcgagcgg tgccgcggtg gcggcgtcgg tgacgagcac
     4981 cgggcggccg agcaggtccc aggcgttgcg cagcttgcgg ttgacctcgt tcggtgtcgc
     5041 gtacgtcgtg gcgacggcca ccggggtcgg cacgaaaccg ccgagcacac aggcccagaa
     5101 cgtcgtgagg tagccccggt tgtcgtcgaa gacgaacagc gcggggtcgc cggggcgcag
     5161 cccggccgcc cgcagccccg ccagcacgcg ctcggcttcg gcgaggagct cggggtaggt
     5221 ctgcagtacg tcctcgttgc cccgggtgac gtagatcgtg cccttgtccg tggccagctc
     5281 ggcggccgcg cgcagcgctt cctggagcgt ggcgggcgcg ccgtccggga tgtgcagggg
     5341 gccgccgtcg aggtcggcca ggggccggtc cgtggcgtcg gcctcgaccg ggccggtcgc
     5401 ctgcggggcg gcgggggcgg aggcgggggc ggtgggggtc acggcgcgta cgcccttgcg
     5461 ggccacggcg atcgcgtcgc cgacgccggg gacgcccttg gccgcggcgg tgatctcgtc
     5521 gagaacggct gagccgagca ggtccgcggc ggtcatgcgg cgctcccgct ccgtgcggat
     5581 tccagcatct tcgagccgat gaacgacacc acttcggcgg ctttctccag gaagtagaaa
     5641 tggccgcccg catatattcg ttcgctgaac tgggcgttcg tgtgctggcg ccagcgccgg
     5701 acggaatgaa gcggtgcctg cgggtccgca tcgctgccga gcgcggtgat caggcagtcg
     5761 agaggctcct ccgacttcac ctggtgtcgc tcccagagcc cgaagtcggc ccggaggact
     5821 tccaggagaa cactcatgac gaattcatcc gcagcgattt cggggtcgat cccgccgagt
     5881 tcgagcaccg cgttgctgaa ttcttcgtcg gagagctcgt gcagctgcct gatcccggtc
     5941 acgtccgggg ccgcgcgtcc ggaaaggaaa agctgttccg ggccgcgccg gccccgcgcg
     6001 cgcagcgcgg tcgtcagttc gtaggcgagt gccgcgccgc aggaatgacc gaagaaggag
     6061 aacgaaccat ccataaccgg gcgaagggca tgggtgagcg cgttgacgag cgggccgacc
     6121 tcggtgaacg gctgctcggc gatgcggttc tgacggcccg gcagctggac tgccaccaac
     6181 tcgatctccg gcggcagcca gcggacccag tcggcgtagg cggccgcgcc ggcgcccgcg
     6241 tgcgggaagc agatcaaccg gtgcgtgtgt cctggttgtt tcgcgcgcca gatgtacggg
     6301 gtctcgggga caagttccct ggtctgtacg gtcatctgca ggcaactcca tgctcgacgt
     6361 tgtcccgtcg acaggacagc ggaatgtctt gtggatcacc ggggcacggg cgcacgacgc
     6421 tgtcactgac cgccgtcggc ttcaccagcc caaccacccg tattggccag gcggtctatt
     6481 aaatccggcc accacataac catcgcactc acatcgagcg caaggtatcc gctgcccccg
     6541 cagagcaacc tgtccggccg acaggacagg aatggattgc ggagagaagc atgacgtaat
     6601 aggaatccgc ttgacggttg gacgtccggc ccctccagtg atccatgagc agccggaccg
     6661 atacggctgc gcgttcccgg actctggaca caagcaaatt ggtggggttg tgtcgggtgc
     6721 acgcgtgttg aatcccaccg agaatctgtg aggctttcga tggaataccg cattctcggc
     6781 cccgtggaca tacaggacgg cggcctcgcg gtgccgctgg atggggcaaa acagcggaca
     6841 gtcctggctg ccctgctcat cgccgagggc tcactcgtgt ccgacacgga actgagcagg
     6901 ctcctgtggg gggaacagcc gccggcgacg catggcgccc agatctacaa tcacgtctcc
     6961 cggttgcgca agacactcgg cagcgaggtc agcatcaccc gctgttcacc cggatacctc
     7021 atggagatcg gcgacgactc cttcgatctc cgcgagttcg agaacctggc gatgcgcggg
     7081 cagtcggcgt tgctcgcggg ccgtttcgag gaggcgagcc agcctctgca cctcgcgctc
     7141 tcgctgtggc gcgggcccgc gctcgccgac gtctcggagg cactggccct caccgaggga
     7201 ccacggatcg aggagcgccg gatctccgtg gtggagagca ggatcgaggc ggacctcgcg
     7261 atcggcaagc acgccgaggt gctccccgaa ctgaccaggc tcgtcgagca gtaccccttg
     7321 cgtgagcggt tccgcgccca gctgatgacc acgctgtacc ggtgcgaccg ccaggccgag
     7381 gcgctggtgc tgtacgactg gagcaggaag atgctcgtcg aggagctcgg cgtcgagccg
     7441 ggagcgctgc tccgccaggt tcatcacgcc atcctcaccg ccgaccccag tctgcacagt
     7501 ccgttcggcc tccagctcgc ccgctgacgc gtcaggcccg ttggccggcc gacacgtcgg
     7561 caggcgacca ccggccgtac gagcgcaggc cgtacagcaa cgggcggcag gcatcctgtc
     7621 cgtgcacgcg cgtcgcctcg ccgaacacca ccacgtggtc gccgaccgat tgcgtcatcg
     7681 cgacccggca atccgcgatc gcgtgcgcgt catcggggag gtgcggcccg gcggcgtcga
     7741 cgtcctgctc ccagcggacg cgctcgaacc ggtccggatc gccggacgcg aacagttccg
     7801 cggtggcccg cgcgtcctcg tggagcaggt tcaccgagaa cgcgccacgt gcctcgatcg
     7861 ccgccagcgt agggctgccc gcgcgcaggc acaccagcag cgtcggcggg tccagcgaga
     7921 cgctgcacac cgacgaacac gtcagtcccc acggctgtcc gtcgaggtcg accccggtga
     7981 cgacggccac gccggtgggg aagccgcgca tcatcgcgcg caacccctcg gacgcggacg
     8041 cctcgaccgg gcgggtgatg ctcaaatcag tcatggagaa tcatcctgtg acttggatcc
     8101 gacagaggtg cggacgggct ggcccgggct ccatttggtc agcagcagca ggggtccggt
     8161 catgacggtc gtcgcgaccg ccatgacgat gagggcgacg aacaccggac gggtcaggat
     8221 gtccgcgttg tagcccacct tgagcacgat cagttcggtg aggccgcggg tgttcatgag
     8281 gatgccgacg gtgaccgcgg tctgcttcgg ctggcccgcc atccgggtac cgaagtagct
     8341 gcccatcccc ttgcccagaa ccgcgagcag gatcgcgccc gccgtgagcg cccagggcag
     8401 cgggccgatg ccgcccgcga acacggtcac tcccgtcacc acgaagaaga acgggatcat
     8461 gcctcggccc aggttcgtca ccctgttggc cacctgctgc cacgggccgt ccggcggcag
     8521 ggcgagaccg acgagcaccg ctccgaagat cgcggtgaga cccagccgtt ccacggtgag
     8581 cgccatggtg agcgcgatcg cgcccaggag caccgcggtg acgaggggcc gctgttcgca
     8641 caggttgtgg gcggcccggg tacgcagagc gctgcgcact cccaacgccg ccgccgcgcc
     8701 cccgccgagc accacgacgg actggacgaa tccgttcaac tcgccggtgc tgagcccgac
     8761 cgccacggac aacagcagcc agccgaccgt gtcgatgacc acggctgcgg tcatcgacag
     8821 gcgtccctcc agggtgtcgg tcgcgttccg ctcggcgagg atcctcgcca gcacgggcac
     8881 cgccgtgatc gacagcgcca cggcgcacat caacacgaag gcgggcagcg gtgcgctgcc
     8941 ccggacatcg gggtcgtccg acaggaggat ccagccggcg aacagcacgc cggagaacat
     9001 ggcgggcacg agtccgcccg ccaccagcca cgcggacgtc cgcaacgaac tccggtgggc
     9061 accgagccgg agcttgtgcg ccagcccgac gaggaacagc accaggccga cttcggccac
     9121 cagcttcatg atgtcgagga cgtcgcccgg cagcaccgcg tcgaacttcg agcggccgag
     9181 gagtgccacc gcggcaggcc cggcgagcag gcctgccacg atctcaccca cggtttccgg
     9241 ttgccgcagc aggcgcgccg cgctccgacc ggcatagccg atcaccagca cgacggccag
     9301 ggccgcggca acatggaccc ccgtcagcag gaagtcagtc acgaccgttc acgcatcgac
     9361 gcgaagtact cgtaggtgct cggcagcgtc tcgatcaggt gccgcgactt gtcacggatg
     9421 gccgcgaact ccttgtgggc cgccgcggtg tcggacatgc ccagggaggg cgtcgccctg
     9481 gccgggatgg cgccggtgcc gagcaggatg cacatgtagg agtacggcgg caggccgtgg
     9541 tagtagggga agacgttctc cgagtcgggc agctgcacct tccagcgctc caggcgctcg
     9601 gcgagcccgt ccgggacggc ccgggtcttg gtgtccttcc agtactgggt gtcgtcgcga
     9661 cccgcgccct ggtagtgcag gaccaggaac tcccgtacgc cgtccatgac gttggcgatg
     9721 gacgagttgt agctcttgcg cagctccggg ctccagtcgg cggccgggaa gtgcttcacc
     9781 atctgctcga tcgcgtggtg gatgaagaag atcccggtcg actccagcgg ctcgacgaag
     9841 ccgctggcca ggccgatggc gacacagttg ttcttccacg actgctcgct gcggccgatc
     9901 cgcatccgga tgtggttggc ctcgacctcg gcggcctccg ggccgacgaa ctcgcgcagc
     9961 gtgcgctcgg cctcctccgg cgagaggtag tccttggcgt agacgtagcc cgtgccgatc
    10021 cgcccgaaca gcgggatcgt ccagatccag cccgcgtcct gcgcggtggc ctgggtgtac
    10081 gggttgatgc cgcgcttctc catgtccagc gggacctgga gggcgaccgc gctgtcgttg
    10141 ggcagcgtgt cctggtagga gatgaacggc acttcgagcg ccttgttcag gagcacgccc
    10201 cggaacccgg tgcagtcgac gaacaggtcg ccctcgaggg acccgtggtc cttggtgacg
    10261 atgtggtcga tccacccgcg ctcgtcgagc cgcacgtcct ggacctcgtc gatgatgtgg
    10321 tgcacaccgc ggtccgtcga gtacttggtg aggtacttgg cgagcagcgc cgcctcgaag
    10381 tggtaggcgt acgggaactg cgtcttgccc tggtgctccg acatggtgag accggagagc
    10441 tccttggcgc cctcggcgaa cccctggtcg atcagcgagc cgtccaggaa gcgcgggctg
    10501 cgtccggcgt cacagaggtt cgccatgacg aagcagtcgg tgtcgaaccg gtcggtgggg
    10561 ccgtcctgca gccaccagtc ggtcagcggg aacccgttga ccgtgggcat ctgctcgaac
    10621 gggtggtaga agtgatgccc cttgcgccgc cagtcctgga accggacggc cagcttgtag
    10681 gtggcgttgc acgccggcat ccactcctct tccttgaggt cgaggaactc gaagaagtgc
    10741 cggatatcgc tgaaggtcgc ttcgccgacc ccgatcgtgc cgatcttgcc ggactcaacg
    10801 agggttaccg aaatcttgtc gccgaatgcc ttcttcaagt aagaggcagt catccacccc
    10861 gccgtaccgc cgcctacgat cacgaccctg tcagggttct tcgtactcat cccagcacct
    10921 ctggtccagt tgtcggcctg aattccaggc gcgtgcgtca cttatcgcca acactgacgc
    10981 cgggatctat caagcttcta ttctcgggcc acttttgagg accgctcggg attccgaggt
    11041 gcttaccgga gctgccgccg tcggcgcgct attcatgagc acacaaaacg gccgccgcag
    11101 gatgttcccg cgacggccgc tttgtgcgat gcgatgtgtt tctcagccga acagttccgc
    11161 aagggcttcc atgtccatcg gcaccggaga gagccggtaa tcggccggag gctccacacc
    11221 gaggagatgg cggacgagga agtcccactt acgccggttc acgtaatgct cgtagccgaa
    11281 gtacatgtga tcggctccgg ggacgatgac cagatcgaaa tccttgtccg cggcgatcag
    11341 ggcatcggcg agccggagcg tcaggtcggg cgagacacgg tcgtccaggc cgccgtggag
    11401 cagcagcagc ttcccttcga ggcggtcggc gatgtccacg ttggacgtcg cggcgtaggc
    11461 ggcctcgtcg aaggggccgt ggtaggcctc ggcgtgctcc ttgtcgaggt agcggaagtc
    11521 gtgcatcccg gactccgcga cgccgacctt gaacagctcg gggaagtcga gcagcgcccg
    11581 cagagcggcg aacccgcccg ccgaggtgcc ggtcgccccc acccggtcca ggtccatcca
    11641 gggccgggtc gcagccagtt cgcgcaccgc cgacacgtgg tcggccaggc cggcggccag
    11701 cttgccgtag gtggcgtcgt ggaactcctt gccgcgcccg ggcgtgcccg ccccgtccac
    11761 cgcaatcacg acgaagccca gcgcggcgag cgcctcggct tcgtacccgt accagccggg
    11821 atcgaacgac gggctgaccc ggttgtccat cgggagggcg tgggggtggt cgatgacggg
    11881 gtaccggcgg ctggggtcga acccgtgcgg ccggtacagc aggccgtata tctccgtctc
    11941 cccgtcggcg ccggtcgccc ggaaccgctc cggcgcgctc cagccgcacg cggtgagccg
    12001 cgtgatgtcg gcacgctcca gttcgacgag cgcctttccg tcccagtcgc ggacggtggc
    12061 ggtcggcggg gtgtccgtcg tggacgcgga gtcgatgaag aactccccgt tctccgccac
    12121 cgtgacgacg tggtcgaacg cgtcgtcagt gaccttggcg aacccggttc cgtccaggtt
    12181 cacacggcac acggtccggc ggtaggggtc ctcctcgacg agcccggacg cgatgaagtg
    12241 gaccacccgc cgctcctcgt cgacgcgcag gatctcctgc accgcccacg ggcccgacgt
    12301 cacctgcccg cgcagctcac cggagtcggt cccgtacagg tagaggtggc cccacccgtc
    12361 ccgctgcgag taccagagca gctcccgccc gcccgagagg agcctgacca tcggctgctg
    12421 cagctcccgc tgcgcgggct ccacccgcgt ctcaccggtc tcgctgacca cggtccgcac
    12481 ctcgccggac tccgggtcga gccggtacag gctcagggtg tggacgcctt cttgtcccca
    12541 gcccaggtag tacaccgcgg acccgtcctc cgcccaccac gcccaccggc ggaagatcgg
    12601 cgacatcacc gacatcccca ccgggtccgc ctgtgcggtg acgaccgtgc cgttctcgat
    12661 gtcgatcacc acgaactcgg cgacggtcga gctgtcgtcc ccggggtggg ggtaccgctg
    12721 gctcagcagc ctcggctcgc cccccgcggc gggggcggag tccaccaggt gcgtgcggcg
    12781 gacaccccgg ttgtcggtgc ggtgggtcag cagccgcgtc ccgtcgggcg accacgcgac
    12841 gcagggcggc aggtggggaa gtccgacctt cgccagcagg gtggagtaca tgaggtagtc
    12901 ggggctcgcg ccgtagtcga cgtcctcggt gccgtcggac gtcagcgccc agtcgcggct
    12961 gccgtccagg gaacgcgcgc ggagatcgtg accggcgcgg tacacggcga atttacggtc
    13021 cggcgaaggg acttcgagag ggtttccggg cggggcaccc tcggtcttcc ggcatgcgta
    13081 gtcgtcgagg gatacccgcc aatgctcgcc gaaagcatcg aattccaccg cacccgtggt
    13141 cagttcgaca gcgaagaacg gcagtgcagc cgcatcgact tcctgtcccg attccttggc
    13201 cagcgcgccc gcgagcctct tgtgatcgaa tgcgacatcc ctgacacccg ctttggtgtc
    13261 gacctgaatg aagcgcttcc cctcgggagt tccgacggtg taccagaagc gagacccgtc
    13321 ctcgatccag cgcggcctga tattggtccc gaggacgagg tcccggcgat tgtgccgcag
    13381 caaccgttct gccgtctcgt agacccgccc gtcgagtcga gtcgcatgca ttggttgacc
    13441 ttctttcgag gtggttgccg tgcaatccgg gccggggcgc attacccgcg gatcaccggc
    13501 cgcgccgatc tgggatgacc tcattgctat cagtcggcat cgatcgcgtc gacgagaagc
    13561 gggacaagag gaggcacgcg gcggggaggc ggcgcggcag gggcagcagg agggggagtt
    13621 gtcccgtcgg caggacagga cacacgagtg ccctgagccg gaggtctccg gctcagggca
    13681 tcagtatgtc ggctctcgga cgcggcccgc ccggcccacg ggctagcgcg tggtctcgcg
    13741 gttgaagacc gcccgcgccc acaggtagcc gaccacgatg aggccgaggc accaggcgat
    13801 ggccttcaga ccgtcgttgc cgatctcggt gcccagcatc agcccgcgga gcgtctcgtt
    13861 gatcggggtg aagggctggt actcggcgaa ccagcggagc ccgaccggca tcgagtcggg
    13921 ggtgaccacg gcgctgccga ggaacggcag gaacgtcagc ggggtgggcg cgttgctcgc
    13981 cgtctcgatg gtcttggctc ccatgcccat cgcggccgac agccaggtga cggcgaaggc
    14041 gagcagcacg agcaggccga tggcggcgag ccactcgatg ggggaggcgt ccggccggaa
    14101 gcccaccacg aacgcgaggc cgaggacgaa gacaaggctg atcatggtct ggatgacgct
    14161 gccgaccaca tgccccacca gcacggaggc acgggagatg gccatggtgc ggaagcggtt
    14221 gatgatgcct tcggtcatgt ccgtgcacac ggacaccgcg gtcgtgacgc cgccggaggt
    14281 gaccgccatc aagatgatgc cgggaacgac gaagttggtg tattcgccac ggtcgttcga
    14341 ggcgcccggc agtccgaggc cgtttccgat cgcaccgccg aagacgtaca cgaagagcag
    14401 cagcatcacg accggcatgg ccgcgacgga gagcgtgatc gtgggatagc ggtacatgtg
    14461 cttcagattg cggcgcaaca tcgtcatcga gtcacgcacg gcgtacgcgg aagtgctcat
    14521 cgcagggact ccttcgcaag ttccgtgttg tcagatacct ggccgggaac ctggttgccg
    14581 gtcagagcga ggaagacatc gtcgagatcg ggtgtgtgca ccgtcagcgc ctcggcctcg
    14641 atctgtgcgg cgtccagccg gtcgagcacg gtgcgcagcg ccgggatgct cccgtcgttg
    14701 gggacctgga gcgtgagcgc ttcgtcgtcg cgcagggcct ggcccagggc gcgggccgcc
    14761 acgtcgaggc ggtgcacatc ggcgaactgg agtcggatgt ggccacccgg gatgcgccgc
    14821 ttgagctcgg ccgccgtgcc ctcggcgacg atcttcccgc cgtcgaggac ggcgatccgg
    14881 tcggcgagct ggtcggcctc ttccaggtac tgcgtggtga ggaagatcgt cgtgccctcg
    14941 gcgacgaggt cgtggatgat ctgccacagg ttgcggcggc tgcgggggtc gaggccggtc
    15001 gtcggctcgt cgaggaagat gatgctcggc ctgccgacca gggtcatggc gaggtcgagc
    15061 ttgcgccgca tgccgccgga gaaggtgatg gcgggcttgt cggcgacctc ggtcaggtcg
    15121 aaccgctcga gcagcgcggc ggcccgctgc ttgccctcgt tgcggggcag gtggtgcagg
    15181 tcggccatca ggatgatgtt ctccctggcg gtcagcaggt tgtccaccgc cgagaactgc
    15241 ccggtcacac cgatctcggc ccggaccgcg tccggctccc ggtccagcac gtgccccgcg
    15301 acctgcgcct gccccgcgtc ggcggagatg agcgtggaca ggatctgcac ggtggtggtc
    15361 tttcccgcac cgttgggacc gagcagggag aagaccgttc ccgccggcac ctccaggtcg
    15421 accccgtcga gtacgacctt ctctccgtat gccttgcgca gtccgagggc tgagatcccc
    15481 ttgggctggc cggccatatg ggcggtcgcg gtcatgatgc ccctcctttt cgtggctgtt
    15541 gcgaaggtcg gtctgtgcgg ttcatggtcg tgtcaccggc ctgggcggtt ggcgaacggc
    15601 ctgctcgtac aacggtgttg tgcgtggtgg acgcggtgcg caaggctggt gcgacgccgg
    15661 ccgcgccccg gcgtcgaccg tcctcggccc ggcttcgcgg gtgagcgcga ccgagacatc
    15721 ccggcggggt gtccgccggg gccggctcag cggccgactc cagcgatccg gcgggagatc
    15781 ctgcgggggc acacaggtcc gcaccgcccg cgacagcgac ggccacgaac gtgcgccggg
    15841 gactgtccac atgcagcgcg aggtccatgc cgccatcatg acacaaatct tggcgccatg
    15901 acgagccatg atggcgccac atacgttcag acgtacggga cgggtcgcca gagtaggcgg
    15961 ttcagccctc caagaaggcc ggacagcacc gggagttaga tgtaacctct ggccatgcca
    16021 caggcgccag gatggcgcag tcgaggcacc cccgcaccca tggcacacgt cggagacgcc
    16081 gccggaggag ggcacggggg tgagttcgtc tcgtcaggac acagtgccac ggccaccggg
    16141 ccatgagctg gcagcatctt ggagccatgc atggcgcgac gcgaaagcgc tccatgtccg
    16201 gcgtgcgcac gagaggcgcc cggcgggcga gcggcccggc agggagagtc cgaggggcga
    16261 cgcggagaat ccgagggttg gcgtggaaaa gccgacgcgg aagaagcgga agaagcagac
    16321 gagccgagct gtacgccggg ttctgttccc cggggcctcg cggccgtcgg ggcgacggcc
    16381 atccatctag ggccggcatt gctgccggcc tcgtgcggtc tacccgcgga ctcgggcggg
    16441 cagccctcgg tcgtccgcgc agaagcgcct ttctcgcgaa gaggcgcttc cttttgacct
    16501 tgctccaggt ggggtttacc tagccgcctg agtcacctca ggcgctggtg gtctcttaca
    16561 ccaccgtttc acccttaccg aggaccgagg tccccggcgg tctgttctct gtggcactgt
    16621 cccgcgggtc accccgggtg gccgttagcc accaccttgc cctgtggagc ccggacgttc
    16681 ctcggggaga tccacaagga cctccacgcg gccgtccgcc cggctcgtct gccgtgtcga
    16741 ccatggtacc cgccggggtg cgggccgggt gccggtggct gccgtggcca ggaaggatcc
    16801 ggcgaggatc agggtgaagg cggcggcgaa ggccgccgtg agggactcgt cgaggaaggc
    16861 gaagcccgcc gctgcggcga cggcggggtt gatgtacgtg aagaccaccg cccgtgtcgg
    16921 gcccgcctcg cggatcagtt cgaggaagac gatgaaggcg agcgccgtgc agatgactcc
    16981 caggcccgcg agcgccgcca gggtcttgcc gtccgggagc gtgtcgggcc aggtcgccgc
    17041 cgccgcgggg gcgtagacca gggcggcgag ggtcaggcag ggcgctatca gttgcagggt
    17101 ggggacgtcc ttgaggtggc gggccacgat caagggggcg atcgcgtagc cgagcgccgt
    17161 gagcaggacc tccgtcaggg accaggcgtc gccgcccgtc aggtgcggga ccgtcagcac
    17221 cgccaccccg gcgaagccga gcgccaggcc cgtcacccgg cgcggtccga ggcgttccgt
    17281 gtctccgaag aagcgggcca ggagggcgcc gatgatcggg acggcggcga tcagcaggcc
    17341 ggcggtggag ctggacaggt ggcgttccgc gtccgtcagg gtccaccacg ggccgaggat
    17401 ctccaccgcc gcgaaggcca gcatcggacg ccagtgcgta cgcagtacgg cgggcatgcc
    17461 gccctggcgc atcgcgaacg ggagcagcag cgcggcgccc agggcgcagc gcgtgaacac
    17521 caccatcgac ggcgtcagat cgctgtccac cgccaccttg atcatgaggt acggaatgcc
    17581 ccacaggaca cccatgaagg agaagagaag ccagccgcgt gcagtcatgc ggcgagtttc
    17641 ggacaggacg gttggttacg tcttgaacgt cgttgcggtc gccgggcccg cctcgtcccg
    17701 gcgcgtcggg gccgtcgcgg cgcgcacgct gtcgcggtac gccgccggtg tcacccccac
    17761 cacccgccgg aaccagcgcg tcagatgcgc ctggtcggcg aagcccacca ggcccgccac
    17821 cgccgccggg cgcagtccgc gttccaggag gccgcgcgcc cgcccgacgc ggtactgcgc
    17881 cagccacgcg tacggcggca tccccgtcgt cgtacggaag gcgcgcagga gttggtagcg
    17941 ggacaggccc agttcggtgg ccagttcggt gagggtgggg ggtgccagga cgctgtcggc
    18001 cagacggtcg cggacggtcc gggcgatggc ggtggtgccc gggacggcgg tgccctcgcg
    18061 gccgcggtct ccggcgcgga gggggcgcgc ctccgcgtgg cgtcgcgcca gggcggcgaa
    18121 cagttcggtc aggcgggtct cggcggccag ggcggtcagg aggtccggga cgtccgccgc
    18181 cgggtccagg atctccgctc cccgggccgg ggccctgctc agccccgtgt gcgccgcccg
    18241 cagcgccgcc gcgagctgcg ggtcgtcgag gaccgcctgc cggaagtgcg gcagggcgcg
    18301 ggcgccgtcg gcgaagaggt gcaccgcggg gtacatcgcg cggtacgcgt agccgccgcc
    18361 ggggccgggg cggccggtgt gggtctcgcc gggggccagg acgacgacgg cgccggggcc
    18421 cacgtcgagg cggccgccac ggtagtcgat gatctcgctg ccgccgacgc agacgcccac
    18481 ggtgaactcc tcgtggtagt gcggggcgta acggtggcgg tcgaagcggg cggtgaggag
    18541 atcgagggtg gtgtcggtgc ccaggggggc acgggtccag attgcgcggt cggcgggggt
    18601 gaaggcctgc ttcgtgtgcg ccatgtgccc tcgtcctctc cgcgtccggt tcaccgttca
    18661 acgcttccac gcccgttttt catgccgctg ccgggtccac gccgttccgg acggaccctg
    18721 cggggctctc cccgatcccg ccccttcccg aaaccggggc tccgccccgg accccgctcc
    18781 tcagacgccg gaggggctgg atggttgccg gaggggccgc gccgcgaagc gtgcttgacc
    18841 ttgccgtagc gtcaacgttt ctactggagg catgcggatc ggagagatcg cggctgccgt
    18901 cgggctcacg acgcgcgcca tcaggcacta tcaccatctc gggctgttgc cggagcccgc
    18961 gcggcggccc aacgggtacc gcgagtacgg gctgcgtgag gccatcctgc tggcgcgcgt
    19021 gcggcggctc accgagctgg gtctcggcct cgacgaggtg cgggacgtgc tcgccgacga
    19081 cgtggggcgt gagctcaccg aggtcctcgc cgagctggac gatgatctgg cccggcagga
    19141 ggcggacatc agggcgcggc gggagcggct cgccgagctg ctgcagatgt cgcgggaggg
    19201 gctgctgccg ggcgaggggc cggtctcgcc ggggctcgcg gagctgttcg ggcggttcag
    19261 cccggccgag tcggcgaccg ccgccaagga cctggaacac ctggcgctgt tcgacgccac
    19321 cgccgacccg gaccgccgcg accgcatcta ccaggccctg agcgagctcg ccgacgaccc
    19381 cgaactcgcg gctcggctac gggagttgta cgcccgcatg gacgacatcg ccgacgcgtc
    19441 gccggacgac ccgcgggtcg agccgctcgg caaggacctc gcggccatcg tccccgacga
    19501 cctcctcgcg gccctcgtac acgggggcga gggccgcgag gacggctccc cggcccggac
    19561 ggaccccggc ccgggcagcg ccttcggcga ggcgttcctc gacgacttcg cgcccgccca
    19621 ggcggcggcc gtccgggaga tgctgacggt gctcaccggg cggacggggt ggacgccgtg
    19681 acgcgcctgg tccgggtcgt gcggcggctc gccgcgcacg agctgcgggg gttccacagt
    19741 ctcgcgctgt gggtggcccg gcggcggcac ggcgtggggg cgggggcgcg cccggcggcg
    19801 tacaccgggc cgcagaccgc cctgctcttc ggcttcgcct tcgtggcggt cgtggagacc
    19861 gtcgtcctcg cgctgatcgt gccgtggccc ctcgtgcacg ccgcgctgct gttcgtggac
    19921 gtctacaccg ttctgcagat cgtggcgctg cacgcggcgt ccgtgacccg gccccatgtg
    19981 gtgggcgtgg acgggtcgtt gcgggtgcgg tacgggcagt tcgtcgatct gcggattccg
    20041 gccgccgaca tggcgcgggt cagggtcgag cggcgttacc ccgaggggcg caccgttcag
    20101 atccatgcgg acggcgtcgt cgacatcgcc gtcggcagcc agaccaccgt caccgtcgaa
    20161 ctcgcccggc ccgtcgcctt cgtacggccg ctgggactgc ccgcgcgggc ccgcgtggtg
    20221 cggctgcacg ccgacgaccc gcgcgccctg gtcgacgcgc tcgcacggac ccgtaccgag
    20281 gaggcgggca ggacccgtcc gggcgaccgc acgccgaccg cctcgcaccc cctcacgccg
    20341 gagcgaacag caccttcgcc cgtcccggat cagcctgcgt gagccgcacc cgcagccgct
    20401 cccccagtgg cagcccggcg gagccgcccg caccgccggg acccgcctcg atgcgggcga
    20461 ccaccgcggg ctccgccaac tgcaccgtcc ccacccccgg ttcgcgttcc ttcacgtcga
    20521 ccaccacccc gtcgaacacc tcccccaccc ggtccttcag gagcgccgcc tcgacgatgt
    20581 cgacgcagcc gcgctccacg gcgttggcgc ggcgggtgcc gtcggccatc tcccggggca
    20641 gctcgggcag ggcggcgagg acccagtccg gcggctcggc gcccgcgcag gcggcgaggc
    20701 agagctcggc ggcgtagcgg tcgacgaggc ggcgcagcgg ggcggtgcag tgggcgtacg
    20761 gggcggccac cgcggcgtgc gtcgtcagtt cggggacctc gccgccgctg aacgccgtgt
    20821 acccggcgcc gcgcagcagc gtcgtgcact cctggaggaa cgccgcgtgg tgcgggtcgc
    20881 gcgggtcgag ggagcggacg aggccggcgt acgggacgtg gtgcggccag tcgatgccga
    20941 gggccttcgc ggtgtggcgc aggcgggtga cggcgccgtc gggggcgagc ggcagggtgc
    21001 gcaggacgcc ggtgccggag gcgatcatga ggtcggcggc ggccatgccg gtcaggaggg
    21061 agatctgggc gttccagccg tcggcgggca gcggggcgcg gaagccgagc gcgtaggtgc
    21121 cgtcctgctc ggtgacctcc tgctcgggca cgttcaggga gatgccgccg cgctcggcct
    21181 cccgttgttc gcgcagccgc ccgatgtcgg cgagcagggc gaccggctcc tcggcggtgc
    21241 ccgcgtcgat ggcgcgctgg acgccctcgt agtcgagttt ggcgcggctg cggaccaggg
    21301 cgcggcgcac gtcggtgcgg gcggtgcggc cctccgcgtc caggtccagg gtccacagga
    21361 cggccgggca ggtctggtcc gggagcaggc tggcggcgcc ctcgctgagc ggggtggggt
    21421 gcagggggac cttgccgtcg gggaagtaga gggtggtgac gcggcggtgc gccgtcgcgt
    21481 ccagcggtcc acccggtgtg acgtacgcgg ccacgtccgc gatcgcgtac cgcacccgga
    21541 agccgccgcc cgcccttcgc gacaggtgca tcgcctggtc caggtcgacg gacgtcggcg
    21601 ggtcgacggt gaagaagggg acgccggtcg cgtcctcggc cgggagccgc ggcgccgccg
    21661 cggcgcgctc ggcctcggcg agcacgtcgg ccgcaaaagc ctccggtacg tccagctcgg
    21721 cgcgcagagc gcgcagcgcg gcccgcagcg gagcctcggc tgcgccggtc acatgcaggt
    21781 ggcggcgggg catgcaccga gcgtatggcg ggggccgggg gtcggcaccc cgtacgcttt
    21841 cgcgggggcc gcaccccccc cgcacgcacc cggctgacag ggcccgtatc cggccgcgag
    21901 gacggccgac gggtcccgtg cccggccaag aaggaaaacg gagaagcgat cgtgctcgtc
    21961 ctgttgccgc cgtccgaagg caaggccccg tccggacgcg gagcgcccct gaagccggag
    22021 tcgctgtccc tgcccgggct cgccgacgcg cgcgccgccg tcctcgacga actcgtcgag
    22081 ctgtgcgtgg ccgacgagga caaggcgtgt gcggtgctcg ggctcagcga ggggctgcgc
    22141 ggggaggtcg gcaagaacgc cgagctgcgg accgccgggg cgcggcccgc cggggagatc
    22201 tacaccggtg tcctctacga cgccctcggc ctcgcctccc tcgacgccgc cgccaagcgg
    22261 cgtgccgccc gctcgctcct cgtcttctcc ggcctctggg gtgccgtccg cgtcaccgac
    22321 cggatcccct cctaccgctg ctccatgggc gtcaagctgc ccgctctggg cgccctcggc
    22381 gcgcactggc gcgggcccat ggcggccgtg ctgcccgagg ccgccggcga cgggctcgtc
    22441 ctcgacctcc gctcctccgc gtacacctcc gcgtggaagc ccaaggggga ggtggccggg
    22501 cggaccgcca ccgtgcgggt gctgcactcc caggtcgtcg acggggtcga gcggcggtcc
    22561 gtcgtgtccc acttcaacaa ggcgaccaag gggcgcctgg tgcggggcct gctgaccgcg
    22621 ggcatctccc ccgcggggcc cgccgagctc gtctccgcgt tgcgggatct ggggtacgtg
    22681 gtggaggcgg aggcgccctc gcgggccggg cgggcgtggg cgttggacgt ggtggtgcgg
    22741 gagatccact gagggtgcgg gggggttcct gccggggcag ccccggtccg cgttgcggag
    22801 aatgcaacga cctttgcgca gggcgcgcgc cgcgggcacg atgaggccat gaaccccgct
    22861 gccgccgcca aggcctccgt gctggacctc gccccggtcg tccccgtcgt cgtcatcgac
    22921 gacccggcgg acgccctccc cctggcgcgc gccctggtcg cgggcggcct cccggcgatc
    22981 gaggtgacgt tgcggacacc cgtggccctg gacgcgatcc gggtcatcgc ggacggggtc
    23041 ccggacgcgg tcgtcggcgc gggcacggtc atctcggcgg ggaacgtcga ggacgccgtc
    23101 gacgcgggcg cccgtttcct ggtcagcccc ggctggacgc cgacgctcct ggcggcgatg
    23161 aaggcgtcgg gcgtaccgtt cctgccgggc gtctcgacga cctcggaggt cgtcgcgctg
    23221 cttgagcacg gtgtcgagga gatgaagttc ttcccggccc aggcggcggg cggtacgccg
    23281 tatctgaagt ccctcgcggg tccgctcccc caggcccgct tctgcccgac gggcggcatc
    23341 tcggcggcct ccgccccgga ctacctcgcc ctgcggaacg tgggctgcgt gggcggcagc
    23401 tggatgctcc cggcggacgc ggtcgcggcc aaggactggg cgcgggtgga gtccctggcc
    23461 cgcgcggcgg cggccctgcg ctgaggaccg ccgcgtacgg ccgacgccgc gtcggccccg
    23521 ccccgcgccc tcagcgcaga tgcgccgtgt cgttcagcag ccgcacgctc gcgttgccgt
    23581 ccgtgtagta cgccaccgcc gacagcgagg ccgccgagag ctccatgcgg aacagggact
    23641 cgggcggggc gccgagggcg aggcggacga gggtcttgat gggggtgacg tgcgtgacga
    23701 gcagcacggt gcggcccgcg taggcggcca ggagcttttc gcgggcggcc tcgacgcggg
    23761 tcgagacctc ggcgaaggac tcgccgccgg gcggcgcgac gtccggcgag gccagccacg
    23821 cggtcagctc gtcgggctgc cgttcgcgca cctccgcgaa ggtgagacct tcccagtccc
    23881 cgaagtccgt ctcgcgcagg ccctcttcga ggtggacgtc gaggccgagc cgggcggcga
    23941 cggtacgggc ggtctcctgg cagcgcagga gcggggagga gacgacggcc tgtacggtgc
    24001 cgcgcgcggc cagcgcggcg gcgacgcgga cggcctgctc ccggccggcg tcggagaggg
    24061 aggggttgct cccgccgctg ccggagaagc gcttctgggg cgtgaggggg gtctcgccgt
    24121 gccggaggag cacgaaggtg gcgggcgcgc ccaggtcggc ggcggcgccc cagccgacgg
    24181 gcggcaccgc cgtaccgggc acgtcggccg cggcgaccgc accggccccg ctcgcggcag
    24241 cacccgcgcc ggacccggcc gccacggacc gcgcggcccg cacgtcggcc acatcggcca
    24301 cgcccgccga gccctgcgcc cccgcggtcg cgtcgccgag ggaaccggcg gtgaacccac
    24361 cgcccccggc ctcggcgccg cgccccgcgg ccgccccggc cagcgcggcc cgcgccttcg
    24421 ccgcccccgc cgccgcgtcc ccgggcggcc cggcgggcgc accggcgccc gccgtgcgca
    24481 cgggccggtc cagctcggcg gtggacgccg acggcgacca ctgctcgccg cgcttgcccg
    24541 cgtccatggc ctcgttggcg agccggtccg cgtgcttgtt ctgctcgcgc gggatccact
    24601 cgtacgtcac ctgggtgccg ggcaggaccc gcgcggcctc ggcggcgagg ggcttcatgt
    24661 cggggtgctt gatcttccag cggcccgaca tctgctcgac gacgagcttg gagtccatgc
    24721 ggacgtgcac gctcgccgcc gggtccagcg cgcgggccgc cttgaggccg gcgaccaggc
    24781 ccttgtactc ggcgacgttg ttcgtcgcga cgccgatgta ctccgcggcc tcggccaggg
    24841 tctccccgga cgccgcgtcg atgacgaccg cgccgtaccc cgcgggcccc gggttgcccc
    24901 gggacccgcc gtcggcctcg acgatgaact cccgcaccgt gcgcgcccct tacagaccgg
    24961 actcggaggt gcgcaccagg atgcggctgc agttctcgca gcgcacgacc ttgtcgggcg
    25021 acgcggcctt gatgtcgttc acctcggtga tgtccagctc caggcggcag ccctcgcagc
    25081 gccgctggtg gagcttggcc gcaccgacgc cgccctgctt cgcgcgcacc ttgtcgtaga
    25141 gggcgagcag gtcggcgggg atcgaaccgg cgacgagcgc gcgctccttg gtgatgttcg
    25201 cggcctcgct gtcgaactcg gaggtcgccg cgtcccggcg gcccgtcgcg tcgtcgatct
    25261 tcgactggac ggagccgacg cgctcggtca gctcggccac ccgctcctgc gcggactcac
    25321 ggcgctccat gacctccagg acgacgtcct ccaggtcgcc ctggcgcttg gcgagggagg
    25381 cgatctcctt ctggaggttc tccaggtcct tcggggagct gaccgcgccg gagtcgaggc
    25441 gcttctggtc gcgggcggcg cgctggcgca cctggtccac gtcctgctcg gccttggtct
    25501 gctcgcgggc gcagtcgctc tcctccgtcg tcgcggcgac gagcaggtcg cgcagt
//
