LOCUS       NZ_BMVQ01000046         6474 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces anthocyanicus strain JCM 4739 sequence46, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVQ01000046
VERSION     NZ_BMVQ01000046.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces anthocyanicus
  ORGANISM  Streptomyces anthocyanicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceoruber group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 6474)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:14:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,934
            CDSs (total)                      :: 7,858
            Genes (coding)                    :: 7,681
            CDSs (with protein)               :: 7,681
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 73 of 177
            Pseudo Genes (incomplete)         :: 130 of 177
            Pseudo Genes (internal stop)      :: 16 of 177
            Pseudo Genes (multiple problems)  :: 37 of 177
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:48:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 6474
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVQ01000046.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..6474
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     protocluster    1..6474
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[833:>6472](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(834..>6472)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     aSDomain        complement(<1..804)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39065_Cglyc.1"
                     /domain_subtypes="Cglyc"
                     /evalue="1.40E-102"
                     /label="IE283_RS39065_Cglyc.1"
                     /locus_tag="IE283_RS39065"
                     /protein_end="279"
                     /protein_start="11"
                     /score="334.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVLDG"
                     /tool="antismash"
                     /translation="IEDILPLSPLQEGFVFLGLLHTEGPDLYIGQVAFDLEGPFDGARM
                     REAARALLRRHANLRAGFRQRKNGAWAQLVLREVDLPWQDADLSTLSEEERRAEADRLA
                     AADRARRFDLGRPPLLRFTAIRLSADRVRLVMTNHHIVLDGWSMPVLLRELMALYAAEG
                     DPSALPRVRPYRDYLAWLDARDRDAARDAWRRSLSGLDEATLLAPDAGPASTAPSQVSF
                     TVDSEVSGALSAWARGQGVTMNTVVQGAWALALAQATGRDDVVFGA"
     gene            complement(<1..837)
                     /locus_tag="IE283_RS39065"
     CDS             complement(<1..837)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (7-34). E-value: 3.6e-08.
                     Score: 24.5. Matches aSDomain:
                     nrpspksdomains_IE283_RS39065_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Cglyc (11-279). E-value: 1.4e-102.
                     Score: 334.9. Matches aSDomain:
                     nrpspksdomains_IE283_RS39065_Cglyc.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="IE283_RS39065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_246551193.1"
                     /sec_met_domain="Condensation (E-value: 6.4e-58, bitscore:
                     183.2, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQQPTRARGKIEDILPLSPLQEGFVFLGLLHTEGPDLYIGQVAF
                     DLEGPFDGARMREAARALLRRHANLRAGFRQRKNGAWAQLVLREVDLPWQDADLSTLSE
                     EERRAEADRLAAADRARRFDLGRPPLLRFTAIRLSADRVRLVMTNHHIVLDGWSMPVLL
                     RELMALYAAEGDPSALPRVRPYRDYLAWLDARDRDAARDAWRRSLSGLDEATLLAPDAG
                     PASTAPSQVSFTVDSEVSGALSAWARGQGVTMNTVVQGAWALALAQATGRDDVVFGA"
     source          1..6474
                     /culture_collection="JCM:4739"
                     /db_xref="taxon:68174"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces anthocyanicus"
                     /strain="JCM 4739"
                     /submitter_seqid="sequence46"
                     /type_material="type strain of Streptomyces coelescens"
     cand_cluster    1..6474
                     /SMILES="NC(c1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     CDS_motif       complement(250..288)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39065_0003"
                     /evalue="8.30E-04"
                     /label="C4_DCL_171-183"
                     /locus_tag="IE283_RS39065"
                     /protein_end="196"
                     /protein_start="183"
                     /score="11.9"
                     /tool="antismash"
                     /translation="PYRDYLAWLDARD"
     CDS_motif       complement(328..393)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39065_0002"
                     /evalue="1.80E-14"
                     /label="C3_DCL_135-156"
                     /locus_tag="IE283_RS39065"
                     /protein_end="170"
                     /protein_start="148"
                     /score="45.9"
                     /tool="antismash"
                     /translation="NHHIVLDGWSMPVLLRELMALY"
     CDS_motif       complement(610..729)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39065_0001"
                     /evalue="3.40E-17"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE283_RS39065"
                     /protein_end="76"
                     /protein_start="36"
                     /score="54.7"
                     /tool="antismash"
                     /translation="DLYIGQVAFDLEGPFDGARMREAARALLRRHANLRAGFRQ"
     aSDomain        complement(736..816)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39065_NRPS-COM_Nterm.1"
                     /evalue="3.60E-08"
                     /label="IE283_RS39065_NRPS-COM_Nterm.1"
                     /locus_tag="IE283_RS39065"
                     /protein_end="34"
                     /protein_start="7"
                     /score="24.5"
                     /tool="antismash"
                     /translation="ARGKIEDILPLSPLQEGFVFLGLLHTE"
     CDS             complement(834..>6472)
                     /NRPS_PKS="Domain: PCP (204-271). E-value: 2.4e-27. Score:
                     86.9. Matches aSDomain: nrpspksdomains_IE283_RS39070_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (286-587). E-value:
                     5.5e-121. Score: 395.1. Matches aSDomain:
                     nrpspksdomains_IE283_RS39070_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (760-1193). E-value: 4e-105.
                     Score: 343.7. Matches aSDomain:
                     nrpspksdomains_IE283_RS39070_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1302-1369). E-value: 2.1e-24.
                     Score: 77.5. Matches aSDomain:
                     nrpspksdomains_IE283_RS39070_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (1385-1695). E-value:
                     1.4e-112. Score: 368.8. Matches aSDomain:
                     nrpspksdomains_IE283_RS39070_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1710-1866). E-value: 2.7e-36.
                     Score: 116.7. Matches aSDomain:
                     nrpspksdomains_IE283_RS39070_TIGR01720.1"
                     /codon_start=2
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028842.1"
                     /locus_tag="IE283_RS39070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_193487654.1"
                     /sec_met_domain="PP-binding (E-value: 7.2e-19, bitscore:
                     55.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.5e-73, bitscore:
                     234.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 5.1e-118, bitscore:
                     381.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PDGPVPIGRPFANTQVYVLDSALRPVAPGVTGELYLAGEQLARGY
                     LGRPALTAERFTANPHSSVPGARMYRTGDLAHWNHHGHLTYDGRADHQIKLRGHRIEPG
                     EIEATLTAQTGIAQATVQLREDTRGDQRLVAYLVVNDSTEYDEPTLRDALASALPDYMR
                     PSAYVTLDALPLTPNGKLDRTALPAPAYSASTTGRTPRTPREEILCTLFAEVLGVDLVT
                     IDDNFFDLGGHSLLATRLVSRARTALGVELSVRQFFETPTIAGLSGAFDRAGRARAALT
                     ARPRPERIPLSYAQQRLWFLHQLEGPSATYNIPTTLRLTGTLDTGALHAALNDLLARHE
                     SLRTTYTEDDEGPRQVIHAWEPGMLPLGVVDTGEGELDAMLSAGVHHAFDLTAGIPVRA
                     TLFRISEQEHVLLLLIHHIATDAWSRTPLAHDLAAAYSARCAGDAPAWEPLPVQYADYA
                     LWQREVLGDEGDADAPAGRQLAYWTRQLADLPEQLDLPTDRPRPAVASQDGDRVAFSLD
                     ADLYVRLTELARATHSSTFMVVQAALAVLLSRLGAGEDIPIGTPVAGRTDDATENLVGF
                     FVNTLVLRNDTSGNPTFRELLEETRRTDLAAYAHQDLPFERLVEALNPARTLAHHPLFQ
                     VMLILSTAETDPDASLALPGLRVGAERSRLGAAKVDLAFALAEVRDGEGRSTGLTGALD
                     FRTDLFDRSTARSLVERFVRTLEAVVADPGVRLSRVPVLTGSERRSLLDRGTGPLLEGL
                     DATLPELFAEQALRTPGAPALVRGGTTVSYAELDLRTNRLARLLRQQGVRPGTPVVMLM
                     ERSPAHVVATLAIAKAGGAYVPLHDTYPLDRMRHVVADTAATLILTDRAEAARAGQLGA
                     RVMVVDEFGAAPSGSEADAAPGTGTSTSTSTSTSTSTGSGSGSGSGSRSGYVDDAPEVG
                     LRPQDLAYVMYTSGSTGVPKGVAVTHRGVVDLVRDHCWRPGVHERVLLHAPHAFDVSCY
                     EMWVPLVSGGTVVVAPPGHLDPAAITDLITAHDITAIHLTAGFFRVVAEEAPECFAGVR
                     EVLTGGDVVSPAAVARVLAHHPRIVLRHLYGPTETTLCVTQHEVTAPYEARGSLPVGRA
                     TGNTRAYVLDRYLQPVPAGVPGELFISGSGLARGYLDRPDLTCERFVADPYGGSGERMY
                     RTGDLVRYNAAGELEYLARADDQVKIRGFRVELGEIEAVLATRPELAQAAVVVREDRPG
                     DRRLVGYVVAAAGRDGEVDPDALRAFSRQALPDYMVPSAFVVLGTLPLTANGKLDRKAL
                     PAPDYGAASTGRAARTPAEELLCTLFAEVLGLSAVGVDDGFFDLGGDSILSIQLVSRAR
                     AAGLALAVRDVFEHQSTARLAAALTDRDDAASVPEAEAVPPYGPAPLTPVMARIAELGL
                     GGDDFNQSVVVSLPPAVDRDRLVPALQRVLDHHDALRLRVLPDGSTEVRAPGSVPAADV
                     LSVVTRAPGATGAARDALLVEAACAARDRLAPAEGRMLQAVLVDGTDDTDGTGGTSGAD
                     GVLILVAHHLVVDSVTWSIVVPDLAAAYRGEEPAPVGTSWRQWATSLARLATDPRVEAE
                     TAHWEHTLTGAGTLRLDRGRDLQGDAGRIGLDLAPHTTEALLTRLPGGVNASVHDVLLT
                     AFAFAVAGWRRGRGEDPDAPVVLDLESHGRHEEAVPGAELSRTAGWFTALHPVRLAPDV
                     TDWARLHQDGDALRDGLKQVKEQLRAVPGDGLGYGLLRHLNPTAGPRLARLPEPDFGFN
                     YLGRRVTPATGTPEPWTVTGGGLAASRPTAPMAHAVELSAVVHEGADGPRLRAEWTYAR
                     RLVPDHDARRLAEQWFRALEALVEQADRAGTGGLTPSDVTLGSLSQSEIEEFESDLESE
                     WEIEQ"
     gene            complement(834..>6474)
                     /locus_tag="IE283_RS39070"
     aSDomain        complement(873..1340)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39070_TIGR01720.1"
                     /evalue="2.70E-36"
                     /label="IE283_RS39070_TIGR01720.1"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1866"
                     /protein_start="1710"
                     /score="116.7"
                     /tool="antismash"
                     /translation="RDGLKQVKEQLRAVPGDGLGYGLLRHLNPTAGPRLARLPEPDFGF
                     NYLGRRVTPATGTPEPWTVTGGGLAASRPTAPMAHAVELSAVVHEGADGPRLRAEWTYA
                     RRLVPDHDARRLAEQWFRALEALVEQADRAGTGGLTPSDVTLGSLSQSEIEE"
     aSModule        complement(873..5612)
                     /complete
                     /domains="nrpspksdomains_IE283_RS39070_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE283_RS39070_AMP-binding.1"
                     /domains="nrpspksdomains_IE283_RS39070_PCP.2"
                     /domains="nrpspksdomains_IE283_RS39070_Epimerization.1"
                     /domains="nrpspksdomains_IE283_RS39070_TIGR01720.1"
                     /locus_tags="IE283_RS39070"
                     /monomer_pairings="Hpg -> D-Hpg"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1260..1322)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0021"
                     /evalue="5.90E-11"
                     /label="NRPS-E6"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1737"
                     /protein_start="1716"
                     /score="34.4"
                     /tool="antismash"
                     /translation="VKEQLRAVPGDGLGYGLLRHL"
     aSDomain        complement(1386..2315)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39070_Epimerization.1"
                     /evalue="1.40E-112"
                     /label="IE283_RS39070_Epimerization.1"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1695"
                     /protein_start="1385"
                     /score="368.8"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDS"
                     /tool="antismash"
                     /translation="GPAPLTPVMARIAELGLGGDDFNQSVVVSLPPAVDRDRLVPALQR
                     VLDHHDALRLRVLPDGSTEVRAPGSVPAADVLSVVTRAPGATGAARDALLVEAACAARD
                     RLAPAEGRMLQAVLVDGTDDTDGTGGTSGADGVLILVAHHLVVDSVTWSIVVPDLAAAY
                     RGEEPAPVGTSWRQWATSLARLATDPRVEAETAHWEHTLTGAGTLRLDRGRDLQGDAGR
                     IGLDLAPHTTEALLTRLPGGVNASVHDVLLTAFAFAVAGWRRGRGEDPDAPVVLDLESH
                     GRHEEAVPGAELSRTAGWFTALHPVRLAP"
     CDS_motif       complement(1392..1439)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0020"
                     /evalue="8.10E-07"
                     /label="NRPS-E5"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1693"
                     /protein_start="1677"
                     /score="21.3"
                     /tool="antismash"
                     /translation="LSRTAGWFTALHPVRL"
     CDS_motif       complement(1530..1568)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0019"
                     /evalue="2.90E+00"
                     /label="Cy4"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1647"
                     /protein_start="1634"
                     /score="1.3"
                     /tool="antismash"
                     /translation="VLLTAFAFAVAGW"
     CDS_motif       complement(1839..1904)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0018"
                     /evalue="1.10E-07"
                     /label="NRPS-E2"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1544"
                     /protein_start="1522"
                     /score="24.3"
                     /tool="antismash"
                     /translation="LILVAHHLVVDSVTWSIVVPDL"
     CDS_motif       complement(2145..2219)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0017"
                     /evalue="3.40E-05"
                     /label="C2_starter_024-063"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1442"
                     /protein_start="1417"
                     /score="16.5"
                     /tool="antismash"
                     /translation="AVDRDRLVPALQRVLDHHDALRLRV"
     aSDomain        complement(2364..2564)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39070_PCP.2"
                     /evalue="2.10E-24"
                     /label="IE283_RS39070_PCP.2"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1369"
                     /protein_start="1302"
                     /score="77.5"
                     /tool="antismash"
                     /translation="EELLCTLFAEVLGLSAVGVDDGFFDLGGDSILSIQLVSRARAAGL
                     ALAVRDVFEHQSTARLAAALTD"
     CDS_motif       complement(2526..2558)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0016"
                     /evalue="1.90E-02"
                     /label="Cy4"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1315"
                     /protein_start="1304"
                     /score="8.2"
                     /tool="antismash"
                     /translation="LLCTLFAEVLG"
     CDS_motif       complement(2616..2642)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0015"
                     /evalue="1.50E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1285"
                     /protein_start="1276"
                     /score="5.2"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     CDS_motif       complement(2862..2927)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0014"
                     /evalue="6.50E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1203"
                     /protein_start="1181"
                     /score="37.3"
                     /tool="antismash"
                     /translation="YLARADDQVKIRGFRVELGEIE"
     aSDomain        complement(2892..4190)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39070_AMP-binding.1"
                     /evalue="4.00E-105"
                     /label="IE283_RS39070_AMP-binding.1"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1193"
                     /protein_start="760"
                     /score="343.7"
                     /specificity="substrate consensus: Hpg"
                     /tool="antismash"
                     /translation="FAEQALRTPGAPALVRGGTTVSYAELDLRTNRLARLLRQQGVRPG
                     TPVVMLMERSPAHVVATLAIAKAGGAYVPLHDTYPLDRMRHVVADTAATLILTDRAEAA
                     RAGQLGARVMVVDEFGAAPSGSEADAAPGTGTSTSTSTSTSTSTGSGSGSGSGSRSGYV
                     DDAPEVGLRPQDLAYVMYTSGSTGVPKGVAVTHRGVVDLVRDHCWRPGVHERVLLHAPH
                     AFDVSCYEMWVPLVSGGTVVVAPPGHLDPAAITDLITAHDITAIHLTAGFFRVVAEEAP
                     ECFAGVREVLTGGDVVSPAAVARVLAHHPRIVLRHLYGPTETTLCVTQHEVTAPYEARG
                     SLPVGRATGNTRAYVLDRYLQPVPAGVPGELFISGSGLARGYLDRPDLTCERFVADPYG
                     GSGERMYRTGDLVRYNAAGELEYLARADDQVKIR"
     CDS_motif       complement(3012..3101)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0013"
                     /evalue="1.40E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="IE283_RS39070"
                     /protein_end="1153"
                     /protein_start="1123"
                     /score="49.3"
                     /tool="antismash"
                     /translation="PAGVPGELFISGSGLARGYLDRPDLTCERF"
     CDS_motif       complement(3603..3662)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0012"
                     /evalue="5.90E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE283_RS39070"
                     /protein_end="956"
                     /protein_start="936"
                     /score="31.0"
                     /tool="antismash"
                     /translation="AYVMYTSGSTGVPKGVAVTH"
     CDS_motif       complement(3966..4004)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0011"
                     /evalue="1.60E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="IE283_RS39070"
                     /protein_end="835"
                     /protein_start="822"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LAIAKAGGAYVPL"
     CDS_motif       complement(4554..4670)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0010"
                     /evalue="9.70E-24"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE283_RS39070"
                     /protein_end="639"
                     /protein_start="600"
                     /score="75.9"
                     /tool="antismash"
                     /translation="RRTDLAAYAHQDLPFERLVEALNPARTLAHHPLFQVMLI"
     aSDomain        complement(4710..5612)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39070_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="5.50E-121"
                     /label="IE283_RS39070_Condensation_LCL.1"
                     /locus_tag="IE283_RS39070"
                     /protein_end="587"
                     /protein_start="286"
                     /score="395.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIATDA"
                     /tool="antismash"
                     /translation="ERIPLSYAQQRLWFLHQLEGPSATYNIPTTLRLTGTLDTGALHAA
                     LNDLLARHESLRTTYTEDDEGPRQVIHAWEPGMLPLGVVDTGEGELDAMLSAGVHHAFD
                     LTAGIPVRATLFRISEQEHVLLLLIHHIATDAWSRTPLAHDLAAAYSARCAGDAPAWEP
                     LPVQYADYALWQREVLGDEGDADAPAGRQLAYWTRQLADLPEQLDLPTDRPRPAVASQD
                     GDRVAFSLDADLYVRLTELARATHSSTFMVVQAALAVLLSRLGAGEDIPIGTPVAGRTD
                     DATENLVGFFVNTLVLRNDT"
     CDS_motif       complement(4719..4808)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0009"
                     /evalue="4.50E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE283_RS39070"
                     /protein_end="584"
                     /protein_start="554"
                     /score="51.1"
                     /tool="antismash"
                     /translation="DIPIGTPVAGRTDDATENLVGFFVNTLVLR"
     CDS_motif       complement(5076..5114)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0008"
                     /evalue="3.90E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE283_RS39070"
                     /protein_end="465"
                     /protein_start="452"
                     /score="19.3"
                     /tool="antismash"
                     /translation="QYADYALWQREVL"
     CDS_motif       complement(5163..5228)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0007"
                     /evalue="4.70E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE283_RS39070"
                     /protein_end="436"
                     /protein_start="414"
                     /score="25.6"
                     /tool="antismash"
                     /translation="IHHIATDAWSRTPLAHDLAAAY"
     CDS_motif       complement(5433..5546)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0006"
                     /evalue="3.80E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE283_RS39070"
                     /protein_end="346"
                     /protein_start="308"
                     /score="57.9"
                     /tool="antismash"
                     /translation="ATYNIPTTLRLTGTLDTGALHAALNDLLARHESLRTTY"
     CDS_motif       complement(5565..5597)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0005"
                     /evalue="3.10E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE283_RS39070"
                     /protein_end="302"
                     /protein_start="291"
                     /score="10.1"
                     /tool="antismash"
                     /translation="SYAQQRLWFLH"
     aSDomain        complement(5658..5858)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS39070_PCP.1"
                     /evalue="2.40E-27"
                     /label="IE283_RS39070_PCP.1"
                     /locus_tag="IE283_RS39070"
                     /protein_end="271"
                     /protein_start="204"
                     /score="86.9"
                     /tool="antismash"
                     /translation="EEILCTLFAEVLGVDLVTIDDNFFDLGGHSLLATRLVSRARTALG
                     VELSVRQFFETPTIAGLSGAFD"
     CDS_motif       complement(5820..5852)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0004"
                     /evalue="3.80E-02"
                     /label="Cy4"
                     /locus_tag="IE283_RS39070"
                     /protein_end="217"
                     /protein_start="206"
                     /score="7.3"
                     /tool="antismash"
                     /translation="ILCTLFAEVLG"
     CDS_motif       complement(5910..5936)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0003"
                     /evalue="5.20E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE283_RS39070"
                     /protein_end="187"
                     /protein_start="178"
                     /score="3.8"
                     /tool="antismash"
                     /translation="GKLDRTALP"
     CDS_motif       complement(6150..6215)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0002"
                     /evalue="7.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE283_RS39070"
                     /protein_end="107"
                     /protein_start="85"
                     /score="34.1"
                     /tool="antismash"
                     /translation="YDGRADHQIKLRGHRIEPGEIE"
     CDS_motif       complement(6303..6389)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS39070_0001"
                     /evalue="4.10E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IE283_RS39070"
                     /protein_end="56"
                     /protein_start="27"
                     /score="51.0"
                     /tool="antismash"
                     /translation="PGVTGELYLAGEQLARGYLGRPALTAERF"
ORIGIN
        1 ggcgccgaag acgacgtcgt cgcgtccggt ggcctgggcc agcgcgaggg cccaggcacc
       61 ctggaccacc gtgttcatgg tcacgccctg gccccgcgcc caggccgaca gggcgccgct
      121 cacctcggag tccacggtga aggacacctg cgagggagcg gtcgacgccg ggccggcgtc
      181 cggggcgagg agggtggcct cgtcgagccc ggacagggac cgccgccagg cgtcgcgggc
      241 ggcgtcccgg tcgcgggcgt cgagccaggc caggtagtcg cggtagggac ggacccgggg
      301 gagcgcggag gggtcaccct cggcggcgta gagcgccatg agttcgcgca gcaggaccgg
      361 catggaccag ccgtccagca cgatgtggtg gttggtcatc accaggcgga cgcggtcggc
      421 ggacagccgg atggcggtga agcgcagcag cgggggccgg cccaggtcga aacggcgggc
      481 acggtcggcg gccgcgagcc ggtcggcctc cgcccggcgc tcctcctcgg acagcgtgct
      541 caggtcggcg tcctgccacg gcaggtcgac ctcgcgcagg accagttggg cccaggcccc
      601 gttcttgcgc tgccggaacc cggcccgcag gttggcgtgc cggcgcagca gcgcccgggc
      661 cgcctcgcgc atccgggcgc cgtcgaaggg gccctccagg tcgaaggcca cctggccgat
      721 gtagaggtcg ggcccctcgg tgtgcagcag cccgaggaac acgaagccct cttgcagcgg
      781 ggagagcgga aggatgtcct cgatcttgcc gcgcgcacgg gtcggttgct ggctcactgc
      841 tcaatctccc actcggactc aaggtcggac tcgaattcct cgatctcgga ctggctgagc
      901 gagccgaggg tcacgtcgga cggggtcagg ccgccggtgc cggcccggtc ggcctgctcc
      961 accagggctt ccagcgcccg gaaccattgc tcggccaggc ggcgggcgtc gtgatcgggg
     1021 accaggcggc gtgcgtaggt ccactccgcg cgcagtcggg ggccgtccgc cccctcgtgg
     1081 acgacggcgc tcagctccac cgcgtgggcc atcggcgctg tgggccgcga ggcggcgagg
     1141 ccgccgcccg tgacggtcca cggttccggg gtgccggtgg ccggggtgac ccggcggccc
     1201 aggtagttga agccgaagtc gggctcggga aggcgtgcga ggcgggggcc cgcggtgggg
     1261 ttgaggtggc gcagcaggcc gtagccgagg ccgtcgcccg gtacggcccg caactgttcc
     1321 ttcacctgct tgaggccgtc ccggagcgcg tcgccgtcct ggtgcagccg cgcccagtcg
     1381 gtgacgtccg gagccagccg caccgggtgg agggccgtga accagcccgc cgtgcggctg
     1441 agttcggcgc ccggcaccgc ctcctcgtgc cggccgtggc tctccaggtc gagtacgacg
     1501 ggcgcgtccg ggtcctcgcc gcgtccgcgc cgccacccgg cgacggcgaa cgcgaaggcg
     1561 gtcagcagga cgtcgtgcac gctcgcgttg acgcccccgg gcaggcgcgt gagcagggcc
     1621 tcggtcgtgt gcggggccag gtcgaggccg atgcgtccgg cgtcgccctg gagatcgcgg
     1681 ccgcggtcca gccgcagggt gcccgccccg gtgagcgtgt gctcccagtg agcggtctcc
     1741 gcctcgacgc gggggtcggt ggccagccgt gccagggacg tggcccactg ccgccacgag
     1801 gtgcccaccg gggcgggctc ctcgccccgg taggccgcgg cgaggtccgg tacgacgatg
     1861 ctccacgtca ccgagtcgac caccaggtgg tgggcgacca ggatcagcac gccgtccgcc
     1921 ccggaggtcc cgcccgtgcc gtccgtgtcg tccgtgccgt cgaccaggac cgcctggagc
     1981 atgcggccct cggccggtgc gagccggtcc cgtgcggcgc acgccgcctc cacgagcagg
     2041 gcgtcgcgcg ccgcgccggt ggcgccgggg gcccgcgtga cgacgctcag gacgtccgcg
     2101 gccggcacac tgcccggggc gcgtacctcc gtgctcccgt cgggcaggac gcgcaggcgc
     2161 agcgcgtcat ggtggtcgag cacacgttgc agggccggga cgagccggtc ccggtccacc
     2221 gcgggcggca gggacaccac gaccgactgg ttgaagtcgt cgccgcccag gcccagttcg
     2281 gcgatgcggg ccatcacggg ggtcagcggg gcgggaccgt acggcggcac cgcttcggcc
     2341 tccggcacgg aggccgcgtc gtcccggtcc gtcagcgcgg cggccagccg ggccgtcgac
     2401 tggtgctcga agacgtcgcg gacggcgagg gcgagtccgg cggcgcgggc ccggctgacg
     2461 agctggatgg acaggatgct gtcgccgccc agatcgaaga acccgtcgtc gacgcccacc
     2521 gcggacaggc cgagcacctc ggcgaagagc gtgcacagca gctcctcggc aggggtgcgg
     2581 gcggcccgcc cggtggacgc cgccccgtag tcgggcgcgg gcagcgcctt gcggtccagt
     2641 ttgccgttgg cggtcagcgg cagggtgccg aggaccacga acgccgacgg caccatgtag
     2701 tccggcagcg cctggcggga gaaggcgcgc agcgcgtccg ggtcgacctc gccgtcccgg
     2761 cccgccgcgg ccaccacgta gccgaccagg cgccggtcgc cgggccggtc ctcgcggacg
     2821 acgacggcgg cctgggccag ctccgggcgc gtggccagga ccgcctcgat ctcgcccagt
     2881 tccacccgga agccgcggat cttgacctgg tcgtcggcgc gggccaggta ctccagttcg
     2941 cccgccgcgt tgtagcggac caggtcgccc gtgcggtaca tccgctcgcc ggacccgccg
     3001 tacggatcgg cgacgaaccg ctcacaggtc aggtcgggac ggtccaggta gccgcgcgcc
     3061 agaccggagc cggagatgaa cagctcgccc ggcacgccgg ccggcaccgg ctggaggtac
     3121 cggtcgagca cgtaggcccg ggtgttcccc gtcgcccgcc cgaccggcag gctgccgcgg
     3181 gcctcgtacg gcgcggtgac ctcgtgctgc gtcacgcaca gcgtcgtctc ggtcggcccg
     3241 tacaggtgac gcagtacgat ccgcgggtgg tgcgcgagga cccgggccac cgcggcgggc
     3301 gagaccacgt cgccgccggt cagcacctcc cgcacaccgg cgaagcactc cggtgcctcc
     3361 tccgcgacga cccggaagaa gcccgcggtg aggtggatcg cggtgatgtc gtgagcggtg
     3421 atcaggtcgg tgatcgcggc cgggtccagg tgtccgggcg gtgccacgac gaccgttccg
     3481 cccgagacca ggggcaccca catctcgtag caggacacgt cgaacgcgtg cggggcgtgc
     3541 agcagtaccc gctcgtggac gcccggccgc cagcagtggt cgcggaccag gtccacgacc
     3601 ccgcggtggg tgaccgcgac gcccttcggc accccggtgg acccggaggt gtacatcacg
     3661 tacgcgagat cctgcgggcg caggcccacc tccggagcat cgtcgacgta cccggagcgc
     3721 gagccggatc cggatccgga tccggagcct gtgctggtgc tggtgctggt gctggtgctg
     3781 gtgctggtgc cggtgccggg ggccgcgtcg gcctccgagc cggacggggc ggcgccgaac
     3841 tcgtcgacca ccatcacccg cgcgcccagc tgcccggccc gcgccgcctc ggcccggtcg
     3901 gtgaggatca gcgtcgcggc ggtgtccgcc accacgtgcc gcatccggtc gaggggatac
     3961 gtgtcgtgca ggggcacgta ggcgccgccc gccttggcga tggccagcgt cgccacgaca
     4021 tgggcgggcg accgctccat cagcatgacc accggcgtgc ccggccgcac cccctgctgc
     4081 cgcagcagcc gggccagccg gttggtgcgc aggtcgagtt cggcgtacga caccgtcgtc
     4141 ccgccccgca ccagcgccgg tgccccgggc gtccggagcg cctgctccgc gaacagttcc
     4201 ggcagcgtcg cgtccagccc ctccagcagg gggccggtcc cccggtcgag cagcgagcgc
     4261 cgttcggacc cggtcagcac cggcacccgg gacagccgca caccgggatc ggcgacgacc
     4321 gcctccagcg tccgcacgaa ccgttccacc agggaccggg ccgtggaacg gtcgaacagg
     4381 tcggtccgga agtccagcgc gcccgtcagc ccggtgctcc ggccctcacc gtcccggacc
     4441 tcggcgagcg cgaacgccag gtcgaccttg gccgccccga gccggctgcg ctccgcgccg
     4501 acccgcagcc ccggcagcgc cagcgaggcg tccgggtccg tctccgccgt gctcaggatc
     4561 agcatcacct ggaagagcgg atggtgcgcc agagtacggg ccgggttcag cgcctccacc
     4621 agccgctcga aggggaggtc ctggtgcgcg taggcggcca ggtcggtacg gcgcgtctcc
     4681 tccagcagct cccggaaggt ggggttgccg ctggtgtcgt tgcgcaggac gagcgtgttc
     4741 acgaagaagc cgaccaggtt ctccgtcgcg tcgtcggtgc gtccggcgac cggggtgccg
     4801 atcgggatgt cctcgcccgc gcccagccgg gatagcagta cggcgagcgc cgcctgcacc
     4861 accatgaacg tactcgagtg ggtggccctg gccagctcgg tcagccgcac gtacaggtcc
     4921 gcgtcgagcg agaaggcgac gcggtcgccg tcctggctcg ccacggccgg ccggggccgg
     4981 tcggtgggga ggtcgagctg ctcgggcagg tcggcgagct gccgtgtcca gtaggcgagt
     5041 tgcctgcccg cgggggcgtc ggcgtcgccc tcgtcgccga gaacctcccg ctgccagagc
     5101 gcgtagtcgg cgtactgcac gggcagcggc tcccacgccg gcgcgtcgcc cgcacagcgc
     5161 gccgagtagg cggcggcgag gtcgtgagcc agcggggtgc gggaccaggc gtcggtggcg
     5221 atgtggtgga tgaggagcag cagtacgtgc tcctgctccg agatccggaa cagcgtggcc
     5281 cgcaccggga tgcccgccgt gaggtcgaac gcgtgatgca cccccgcgga gagcatcgcg
     5341 tccagctcgc cctccccggt gtcgaccacg ccgagcggca gcattccggg ctcccaggcg
     5401 tggatcacct gacgggggcc ctcgtcgtcc tcggtgtagg tggtgcgcag gctttcgtgg
     5461 cgggcgagga ggtcgttgag cgcggcgtgc agggcgccgg tgtcgagggt cccggtgagg
     5521 cggagggtgg tggggatgtt gtaggtcgcc gatggtcctt cgagctggtg gaggaaccag
     5581 aggcgctgct gggcgtagga gagcgggatg cgctcggggc gcggccttgc cgtgagcgcg
     5641 gcccgcgcac ggccggcccg gtcgaacgcc cccgagagcc cggcgatcgt cggcgtctcg
     5701 aagaactgcc gcacggacag ttcgacgccg agtgcggtgc gggcgcggct gacgaggcgg
     5761 gtggcgagaa gcgagtgtcc gccgaggtcg aagaagttgt cgtcgatggt gacgaggtcg
     5821 acgccgagga cttcggcgaa gagagtgcag aggatctctt cgcggggggt gcggggggtt
     5881 cgtccggtgg tggatgccga gtaggcgggg gcggggaggg cggtgcggtc gagtttgccg
     5941 ttgggggtga gggggagggc gtcgagggtg acgtaggcgg aggggcgcat gtagtcgggg
     6001 agtgcgctgg ccagggcgtc ccgaagggtg ggctcgtcgt attcggtgga gtcgttgacg
     6061 acgagatagg cgacgaggcg ttggtcgccg cgggtgtctt cgcggagttg gaccgtggct
     6121 tgggcgatgc ccgtctgtgc ggtgagggtg gcttcgatct caccgggttc gatgcggtgt
     6181 ccacgcagct tgatctggtg gtcggcgcgt ccgtcgtagg tgaggtggcc gtggtggttc
     6241 cagtgggcga ggtcgccggt gcggtacatg cgggcgccgg gaacgctgct gtgagggttg
     6301 gcggtgaagc gttcggcggt cagcgcgggg cggccgaggt agccgcgggc gagctgttca
     6361 ccggcgaggt acagctctcc ggtgacgccg ggggcgacgg ggcgcagggc cgagtccagg
     6421 acgtagacct gggtgttggc gaagggccgt ccgatgggga cgggaccgtc aggg
//
