LOCUS       NZ_BMVQ01000028        26751 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces anthocyanicus strain JCM 4739 sequence28, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVQ01000028
VERSION     NZ_BMVQ01000028.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces anthocyanicus
  ORGANISM  Streptomyces anthocyanicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceoruber group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 54784)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:14:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,934
            CDSs (total)                      :: 7,858
            Genes (coding)                    :: 7,681
            CDSs (with protein)               :: 7,681
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 73 of 177
            Pseudo Genes (incomplete)         :: 130 of 177
            Pseudo Genes (internal stop)      :: 16 of 177
            Pseudo Genes (multiple problems)  :: 37 of 177
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:48:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 14487
            Orig. end                         :: 41238
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVQ01000028.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26751
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26751
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26751
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16751](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16751
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(293..886)
                     /gene="idi"
                     /locus_tag="IE283_RS36980"
                     /old_locus_tag="GCM10010348_74680"
     CDS             complement(293..886)
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129457.1"
                     /locus_tag="IE283_RS36980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74680"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_003972247.1"
                     /transl_table=11
                     /translation="MPITPATATPSSSNGTAEAILLELVDENGVTIGTAEKLSAHQPPG
                     RLHRAFSVFLFDERGRLLIQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEEL
                     GVSPSLLAEAGTVRYNHPDPASGLVEQEYNHLFVGLVQAELRPDPEEVAGTAFVSPAEL
                     TERHAQDTFSAWFMTVLDAARPAVRELTGTSAGW"
     gene            complement(1163..2101)
                     /locus_tag="IE283_RS36985"
                     /old_locus_tag="GCM10010348_74690"
     CDS             complement(1163..2101)
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972246.1"
                     /locus_tag="IE283_RS36985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74690"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_003972246.1"
                     /transl_table=11
                     /translation="MGAGHDHGHAHGGHAGGTATAAYRGRLRVALSITLTVMVVEIVGG
                     LVADSLALIADAAHMATDALGLGMALLAVHFASRPPSDRRTFGYARAEILAALANCLLL
                     LGVGGYVLYEAIDRFVTPADTAAGPTVVFGAIGLVANMVSLSLLMRGQKESLNVRGAFL
                     EVAADALGSLAVIVSALVILATGWQPADPIASLLIGLMIVPRTLRLLRETLDVLLEAAP
                     KGVDIAEVRAHILALDGVEDVHDLHAWTITSGMPVLSAHVVVDGEALSAIGHEKMLHEL
                     QGCLGDHFDVEHCTFQLEPSGHAEHEARLCR"
     misc_feature    2163..2179
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.55"
                     /tool="antismash"
     misc_feature    2195..2209
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     misc_feature    complement(2393..2407)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            2579..4396
                     /locus_tag="IE283_RS36990"
                     /old_locus_tag="GCM10010348_74700"
     CDS             2579..4396
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996269.1"
                     /locus_tag="IE283_RS36990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74700"
                     /product="DUF5941 domain-containing protein"
                     /protein_id="WP_003972244.1"
                     /transl_table=11
                     /translation="MPTAILTGQPVPGSSIESELRSLGFDVHLAAGAAETETLLARVPG
                     EERVAVVDARFVGHPHALRLGLTDPRFPLAAIPGAVTAQPAARQTLTRAMARENSTGGG
                     TAVDVDSLADRITAALDADGAGVHRPELGSLVAAVPADPQARNEARQAVAAVDDEAVRL
                     KSAVKARDGFVTTHFISPYSRYIARWCARRGLTPNQVTTASLITALIAAGCAATGTRGG
                     FVAAGVLLIASFVLDCTDGQLARYSLQYSTLGAWLDATFDRAKEYAYYAGLALGAARGG
                     DDVWALALGAMVLQTCRHVVDFSFNEANHDASANTSPTAALSDKLDSVGWTVWLRRMIV
                     LPIGERWAMIAVLTALTTPRITFYALLIGCAFAATYTTAGRVLRSLTRKATRTDRAAKA
                     LADLADSGPLAEAGAKGLRTAARRLPGFATPAVALLGGAAVVATAALTDFGGPWPLVAA
                     LGYVLTSALAVARPLKGALDWLVPPFFRAAEYLTVLFLAAKADVNGALPAAFGLVAAVA
                     YHHYDTVYRIRGDAGAPPQWLVRTVGGHEGRTLVITLLAVLLTAAQFKVALTVLAVVVA
                     LVVLVESIRFWVAAHQVGAPAVHDEGEPA"
     gene            4393..5145
                     /locus_tag="IE283_RS36995"
                     /old_locus_tag="GCM10010348_74710"
     CDS             4393..5145
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="IE283_RS36995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74710"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_011031156.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.6e-12, bitscore:
                     38.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGAEDSITVLDLTLA
                     NFAEVGLTEVGIIVGYRKEAVYDRQAELEQKYGVKLTLIDNDKAEEWNNAYSLWCGRDA
                     LKDGVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKNLADEEMKVVVDPDKGVQR
                     ITKLMDPADATGEYIGVTLIEGEAAAELADALKTTFERDPQLYYEDGYQELVNRGFKVD
                     VAPIGDVKWVEIDNHDDLAKGREIACQY"
     gene            5133..6194
                     /locus_tag="IE283_RS37000"
                     /old_locus_tag="GCM10010348_74720"
     CDS             5133..6194
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007494151.1"
                     /locus_tag="IE283_RS37000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74720"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_003972242.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.9e-26, bitscore: 84.4,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 7.9e-11, bitscore:
                     33.3, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDIRAGALDDLGCVLADERISHSGKLAVAVSG
                     GSGARLRDRVAPSLPGADWFEVGGGTLDDAIKLAGAMKGGHYDAVVGLGGGKIIDCAKF
                     AAARIGLPLVAVPTNLAHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIRAAPARF
                     VRAGIGDAVSNVSAIADWELANRVKGEKIDGLAAAMARQAGEAVLRHPGGIGDNDFLQV
                     LAEALVLSGIAMSVSGDSRPSSGACHEINHAFDLLFPERAAAHGEQCGLGAAFAMYLRG
                     AHEESANMARVLRRHGLPVLPEEIGFTPEEFFRAVEFAPQTRPGRYTILEHLDLTTDQI
                     KDLYADYVKAIGS"
     gene            6172..6951
                     /locus_tag="IE283_RS37005"
                     /old_locus_tag="GCM10010348_74730"
     CDS             6172..6951
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049651.1"
                     /locus_tag="IE283_RS37005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74730"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_161270333.1"
                     /transl_table=11
                     /translation="MSRPSVAELRPVVHPAGVKDRRSGEHWAGRLYMREVSLRIDRYLV
                     NTRITPNQLTYLMTVCGVLAAPALLVPGIWGAVLGVVAVQLYLLLDCVDGEIARWRKQY
                     SLGGVYLDRVGAYLTDAAVLVGLGLRAADIWGTGRIDWLWAFLGTLAALGAILIKAETD
                     LVGVARHQNGMPPVKEAASEIRSSGMALARRAAGALKFHRLILGIEATLLILVLAIVDQ
                     ARGDLFFTRLGTAVLAGIALLQTLLHLVSILASSRLK"
     gene            6960..7832
                     /locus_tag="IE283_RS37010"
                     /old_locus_tag="GCM10010348_74740"
     CDS             6960..7832
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031159.1"
                     /locus_tag="IE283_RS37010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74740"
                     /product="glycosyltransferase"
                     /protein_id="WP_106518481.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2e-13, bitscore:
                     42.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGAVVITMGNRPEELRALLDSVAKQDGDPVQVVVVGNGSPVPE
                     VPEGVRTVEMPENLGIPGGRNVGIEAFGPGGSDVDILLFLDDDGLLARTDTAELCREAF
                     AADDELGIISFRIADPDTGETQRRHVPRLRASDPMRSSRVTTFLGGANAVRTRVLTQVG
                     GLPDAFFYAHEETDLAWRALDAGWMIDYRSDMVLNHPTTAPSRHAVYHRMVARNRVWLA
                     RRNLPALLVPVYLGVWMALTLLRRPSRPALKAWFGGFREGWATPCGPRRPMRWRTVWRL
                     TRLGRPPVI"
     gene            7931..8860
                     /locus_tag="IE283_RS37015"
                     /old_locus_tag="GCM10010348_74750"
     CDS             7931..8860
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994380.1"
                     /locus_tag="IE283_RS37015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74750"
                     /product="ABC transporter permease"
                     /protein_id="WP_003972239.1"
                     /transl_table=11
                     /translation="MSETTHDGTVAMTKPVSPDEGLTPARLAAKYGLSVSGARPSLKEY
                     VRQLWGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNALVYFLIFGLILDAGRGME
                     KDVYIPFLVTGVFVFTFTQSSAMAGVRAIAGNLGLVRALHFPRASLPVSFALQQLQQLL
                     ASMIVLFLVVVGFGSYPSLSWLLVLPVLVLQFLFNTGLALVVARMGAKTPDLAQLMPFI
                     MRTWMYASGVMFSIPIMLKDKPDWIADVLQWNPAAVYMDLMRFALIDGYGSENLPPHVW
                     AVALGWAVVLAVGGFVYFWKAEERYGRG"
     gene            8853..9641
                     /locus_tag="IE283_RS37020"
                     /old_locus_tag="GCM10010348_74760"
     CDS             8853..9641
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330378.1"
                     /locus_tag="IE283_RS37020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74760"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_003972238.1"
                     /transl_table=11
                     /translation="MAEQQQDQRVPTVIADEVHIVYRVNGAKTGKGSATAALSRILKKG
                     SDDAKRGVRKVHAVRGVSFTAYRGEAIGLIGSNGSGKSTLLRAIAGLLPAERGKVYTDG
                     QPSLLGVNAALMNDLTGERNVILGGLAMGMSREQIKERYQEIVDFSGINEKGDFITLPM
                     RTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQTRSEERIRELKKQAGTIFLVS
                     HNNKSIRDTCNRVLWLERGELRMDGPTDEVLKEYEKFTGK"
     gene            10001..10921
                     /gene="hpnC"
                     /locus_tag="IE283_RS37025"
                     /old_locus_tag="GCM10010348_74770"
     CDS             10001..10921
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042802.1"
                     /locus_tag="IE283_RS37025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74770"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_106518480.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 2e-42,
                     bitscore: 137.1, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 4.3e-41, bitscore:
                     132.6, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTDTAHAVDPERGTLAKAADENFPVAPFFLPRAWRTDLMAVYG
                     FARLVDDIGDGDLAPGGADARLLGVPEDRADDRLLMLDAFEADLHRVFDGSDGSDGAPR
                     HPLLRRLVPTVRRRALTPEPFLGLIAANRQDQLVARYETYDDLLAYCELSANPVGRLVL
                     AVTGTSTPERIRRSDEICTALQIVEHLQDVAEDLGRDRIYLPAEDMKRFHVQEADLAAP
                     SANASVRALIAYEAARARDLLNEGAPLVGSVHGRLRLLLAGFVAGGRAALNAIAAADHD
                     VLPGPPKSGKVHLLREAGVVLRGEG"
     gene            10948..11868
                     /gene="hpnD"
                     /locus_tag="IE283_RS37030"
                     /old_locus_tag="GCM10010348_74780"
     CDS             10948..11868
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996261.1"
                     /locus_tag="IE283_RS37030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74780"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_193487469.1"
                     /sec_met_domain="phytoene_synt (E-value: 1e-58, bitscore:
                     190.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4e-71,
                     bitscore: 231.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPVLAAYSYCEAVTGQQARNFAYGIRLLPTPKRRAMSALYAFS
                     RRVDDIGDGVLADDVKVTRLDETRAVLSRIQDGAVEEDDTDPVAVALADAARRFPIPLG
                     GLDELIDGVQMDLRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYA
                     DTLGLALQLTNILRDVREDAEGGRTYLPADDLAKFGCAAGFNGPTPPEGSDFAGLVHFE
                     VRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREK
                     AYVAVRGLSGLDARHVTRRTVRRRA"
     gene            11868..12026
                     /locus_tag="IE283_RS39530"
                     /old_locus_tag="GCM10010348_74790"
     CDS             11868..12026
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039420.3"
                     /locus_tag="IE283_RS39530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74790"
                     /product="DUF6380 family protein"
                     /protein_id="WP_011031163.1"
                     /transl_table=11
                     /translation="MDTPGTLDTRDPYKTGGGQWRATLRWRSASLTETVSRTPFKHRGG
                     RTGKGAP"
     gene            12023..13459
                     /gene="hpnE"
                     /locus_tag="IE283_RS37035"
                     /old_locus_tag="GCM10010348_74800"
     CDS             12023..13459
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330381.1"
                     /locus_tag="IE283_RS37035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74800"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_193487470.1"
                     /sec_met_domain="DAO (E-value: 2e-09, bitscore: 29.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQGKGTREGGVLADVSALGPGGHAVVVGGGLAGVTTALALADAG
                     VRVTLLEGRPRLGGLAFSFQRGDLTVDNGQHVYLRCCTAYRWFLDRIGGAALAPVQERL
                     DVPVVDLARSEGNRLGRLRRDALPVPLHLGRSLATYPHLSLAERASVGRAALALKGLDL
                     ADPSLDTQDFGSWLTAHGQSARAVEALWDLVGVATLNAVAGDASLGLAAMVFKTGLLSD
                     PGAADIGWARVPLGELHDRLARKALDSAGVRTEVRTRVTSVSVNENGGWSVQVPGETLE
                     ADAVVLAVPQREAHDLLPDGALDAPENLLRIGTAPILNIHVIYDRKVLGTPFLTALGTP
                     VQWVFDRTEASGLKEGQYLALSQSTAQNDIDEPVAVLRERYLPELERLLPRTRGAEVKD
                     FFVTRERTATFAPAPGVGRLRPGARTKAPGLYLAGAWTATGWPATMESAVRSGVGAAAA
                     ALGALGRSRGLLPDFFEEAA"
     gene            13528..14592
                     /locus_tag="IE283_RS37040"
                     /old_locus_tag="GCM10010348_74810"
     CDS             13528..14592
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972234.1"
                     /locus_tag="IE283_RS37040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74810"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_003972234.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.7e-59, bitscore:
                     191.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPAPTADRRTTVDVTALLERGRTLATPVLRAAVDRLAPPMDTVA
                     AYHFGWIDAQGNPADGDGGKAVRPALAVLSAEVTGAAPEVGVPGAVAVELVHNFSLLHD
                     DLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEVLLELGTVEAGRATRRLTKASR
                     SLIDGQAQDISYEHRDRVSVEECLEMEGNKTGALLACASSIGAVLGGADERTADTLEKY
                     GYHLGLAFQAVDDLLGIWGDPDATGKQTWSDLRQRKKSLPVVAALAAGGAASERLGEIL
                     TADAKASDFANFSEEEFAARAALIEEAGGREWTADEARRQHTIAIEALDAVDMPDRVRD
                     RFTALADFVVVRKR"
     gene            14709..16751
                     /gene="shc"
                     /locus_tag="IE283_RS37045"
                     /old_locus_tag="GCM10010348_74820"
     CDS             14709..16751
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031166.1"
                     /locus_tag="IE283_RS37045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74820"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_189285453.1"
                     /sec_met_domain="T2TS (E-value: 3.1e-152, bitscore: 499.5,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSTGASLRPLAASASDTDITIPAAAAGVPEAAARATRRA
                     TDFLLAKQDAEGWWKGDLETNVTMDAEDLLLRQFLGIQDEETTRAAALFIRGEQREDGT
                     WATFYGGPGELSTTIEAYVALRLAGDSPEAPHMARAAEWIRSRGGIASARVFTRIWLAL
                     FGWWKWDDLPELPPELIYFPTWVPLNIYDFGCWARQTIVPLTIVSAKRPVRPAPFPLDE
                     LHTDPARPNPPRPLAPVASWDGAFQRIDKALHAYRKVAPRRLRRAAMNSAARWIIERQE
                     NDGCWGGIQPPAVYSVIALYLLGYDLEHPVMRAGLESLDRFAVWREDGARMIEACQSPV
                     WDTCLATIALADAGVPEDHPQLVKASDWMLGEQIVRPGDWSVKRPGLPPGGWAFEFHND
                     NYPDIDDTAEVVLALRRVRHHDPERVEKAIGRGVRWNLGMQSKNGAWGAFDVDNTSAFP
                     NRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHDPRTRRGIQWLLDAQEADGSWFGRW
                     GVNYVYGTGSVIPALTAAGLPTSHPAIRRAVRWLESVQNEDGGWGEDLRSYRYVREWSG
                     RGASTASQTGWALMALLAAGERDSKAVERGVAWLAATQREDGSWDEPYFTGTGFPWDFS
                     INYNLYRQVFPLTALGRYVHGEPFAKKPRAADAPAEAAPAEVKGS"
     gene            16751..17392
                     /locus_tag="IE283_RS37050"
                     /old_locus_tag="GCM10010348_74830"
     CDS             16751..17392
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431357.1"
                     /locus_tag="IE283_RS37050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74830"
                     /product="lipoprotein"
                     /protein_id="WP_003972232.1"
                     /transl_table=11
                     /translation="MTPQTGPSPLLIACALGIEHLALRTGDRAGAGGPVTVLRTGMGPR
                     AAERSVTRVLADPALEGAAVLATGFCAGLSPGMHPGDLVVAEETRDPRSTVPCVATDRL
                     VKELARAVPGRTVHTGPLTGSDHVVRGPERADLLATGAIAVDMESAATLLSAVRTGPRP
                     VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRSVLPAFFEWHRSLLLPRR"
     gene            17399..18421
                     /gene="hpnH"
                     /locus_tag="IE283_RS37055"
                     /old_locus_tag="GCM10010348_74840"
     CDS             17399..18421
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386169.1"
                     /locus_tag="IE283_RS37055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74840"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_030872948.1"
                     /sec_met_domain="PF04055 (E-value: 3.7e-20, bitscore: 64.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 5.6e-11, bitscore: 34.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVF
                     LCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF
                     RVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEETDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAMRETVSGNRE
                     "
     gene            18426..19580
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="IE283_RS37060"
                     /old_locus_tag="GCM10010348_74850"
     CDS             18426..19580
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031167.1"
                     /locus_tag="IE283_RS37060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74850"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_191851372.1"
                     /transl_table=11
                     /translation="MTAIPLGLPGVPVRPIAERRVSRRIQVGPVAVGGGAPVSVQSMTT
                     TRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYV
                     FAAIEAGCAAVRVNPGNIKQFDDKVKEIAKAAKDHGTPIRIGVNAGSLDRRLLQKYGRA
                     TPEALAESALWEASLFEEHDFRDIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAG
                     PAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPVEEIKVGIQILQSLGLRERRLEIVSC
                     PSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQI
                     FVKGEVVKTVPESKIVETLIEEAMRIAEQMEKDGASGAPAVTVS"
     gene            19606..21576
                     /gene="dxs"
                     /locus_tag="IE283_RS37065"
                     /old_locus_tag="GCM10010348_74860"
     CDS             19606..21576
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972229.1"
                     /locus_tag="IE283_RS37065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74860"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_030873152.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.7e-113,
                     bitscore: 369.3, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.2e-07, bitscore:
                     22.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILENIRGPRDLKALSEAELGELSDEIRDFLVHAVARTGGHLGP
                     NLGVVELTVALHRVFESPDDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREE
                     SAHDVIENSHASTVLGWADGLAKARQVQGERSHVVAVIGDGALTGGMAWEALNNIAAAR
                     DRPLIIVVNDNERSYAPTIGGLANHLATLRTTDGYERALAWGKDVLQRTPVVGHTVYEA
                     LHGAKKGFKDAFAPQGLFEDLGLKYLGPIDGHDIGAVESALRRAKRFHGPVLVHCLTEK
                     GRGYEPALRDEEDHFHTVGVMDPLTCEPLGPAGGPSWTSVFGEEIVRIGEERADVVAIT
                     AAMLHPVGLAPFAERFPDRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQ
                     LLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADQLRAQL
                     REAVAVDDAPTLLRFPKESVGPAVPAVDRIGGLDVLHAANRSEVLLVAVGVMAPVCLGA
                     AELLEARGIGCTVVDPRWVKPVDPALAPLAARHRLVAVVEDNSRAAGVGSAVALALGDA
                     EVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVDVAGRIAASLALAEPAGDRAGGPAVE
                     QPGDGRMSGDGRIVMPAQGEN"
     gene            21577..22962
                     /locus_tag="IE283_RS37070"
                     /old_locus_tag="GCM10010348_74870"
     CDS             21577..22962
                     /NRPS_PKS="Domain: Aminotran_3 (41-363). E-value: 2.9e-91.
                     Score: 297.9. Matches aSDomain:
                     nrpspksdomains_IE283_RS37070_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389116.1"
                     /locus_tag="IE283_RS37070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74870"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_011031169.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.5e-91, bitscore:
                     298.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEFDLAALLAERGAERYELHARHLNHQLPRMLHTIGFDKVYER
                     AEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVLDASLADLTRFDCPPLPGL
                     LAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRILYCPHAFHGLTAGSLSVN
                     GEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVEPVQGKGVHEAPPGYLLAA
                     QELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVCVAKALSGGYVPVGATLGK
                     DWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENEEIVANAAAVGERLKSRLA
                     ELVDRYELLADVRGRGLMIGIEFGRPRSLKLRSRWTMLQAARKGLFAQMVVVPLLQRHR
                     ILTQVSGDHLEVIKLIPPLIVDTDDADRFVDAFTEVMEDAHHGGGLMWDFGKTLVKQAV
                     ANR"
     aSDomain        21700..22665
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS37070_Aminotran_3.1"
                     /evalue="2.90E-91"
                     /label="IE283_RS37070_Aminotran_3.1"
                     /locus_tag="IE283_RS37070"
                     /protein_end="363"
                     /protein_start="41"
                     /score="297.9"
                     /tool="antismash"
                     /translation="VYERAEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVL
                     DASLADLTRFDCPPLPGLLAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRI
                     LYCPHAFHGLTAGSLSVNGEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVE
                     PVQGKGVHEAPPGYLLAAQELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVC
                     VAKALSGGYVPVGATLGKDWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENE
                     EIVANAAAVGERLKSRLAELVDRYELLADVRGRGLMIGIEF"
     gene            23036..23650
                     /locus_tag="IE283_RS37075"
                     /old_locus_tag="GCM10010348_74880"
     CDS             23036..23650
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972227.1"
                     /locus_tag="IE283_RS37075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74880"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_011031170.1"
                     /transl_table=11
                     /translation="MSSSETGPAEGAVAAVAPQLRELRRRAALTLEAAARAAGLSPAHL
                     SRLETGQRQPSLPMLLSLARVYGTTVAELLGESAADRDAVVRAADMEPTAAGGWTYWRA
                     GAPGRGMQALRVQVPYGSQGDVVRVHPGEEWLHVLRGRLRLRLGDTEHRLTAGDSAHFD
                     SMTPHRIAAQDPDGVELLFVHTLLQSPTAALCLGPTPGETP"
     gene            23647..23766
                     /locus_tag="IE283_RS37080"
                     /old_locus_tag="GCM10010348_74890"
     CDS             23647..23766
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031171.1"
                     /locus_tag="IE283_RS37080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74890"
                     /product="DUF6126 family protein"
                     /protein_id="WP_011031171.1"
                     /transl_table=11
                     /translation="MSTMQEKFPRALWVRLIVYIALGHVFGGFLYLLFEVGAK"
     gene            complement(23788..24585)
                     /locus_tag="IE283_RS37085"
                     /old_locus_tag="GCM10010348_74900"
     CDS             complement(23788..24585)
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069689.1"
                     /locus_tag="IE283_RS37085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74900"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_016327864.1"
                     /transl_table=11
                     /translation="MTQQVPSTEPELTGVRNFRDVGGLPTVDGRRVRQGVLFRSGHLAH
                     ATGEDAAFLASLGLHTIFDFRNAADQKLEGPDVDLPGVRNVNLPLSDPADGAEFWKMVR
                     DGDLDQLREILADGKAADRMIGSYRAIVTERTAEHSRILHALAEDSVPALMHCAAGKDR
                     AGLSIAVTLLALGVEREAVVEDYLKSNAAHRRYKVRRSGSAASAYSPEVMELLSPLFDA
                     RAEYLAAAFETVEETWGGVDAYLEQGLRLTPATRERLRERMLD"
     misc_feature    24715..24731
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.89"
                     /tool="antismash"
     misc_feature    24798..24812
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.85"
                     /tool="antismash"
     misc_feature    24805..24819
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.23"
                     /tool="antismash"
     regulatory      25010..25167
                     /bound_moiety="cyclic di-AMP"
                     /db_xref="RFAM:RF00379"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00379"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cyclic di-AMP (ydaO/yuaA leader) riboswitch senses
                     the signaling molecule cyclic di-AMP; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            25172..26110
                     /locus_tag="IE283_RS37090"
                     /old_locus_tag="GCM10010348_74910"
     CDS             25172..26110
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972224.1"
                     /locus_tag="IE283_RS37090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_74910"
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_193487471.1"
                     /transl_table=11
                     /translation="MPAKGKHRRTRAMRLTRTIAVAGTGGAALALPLMGAAAANAAPAH
                     SVSEQAVQSVPASAKKAAAEKNSDSRTYTVKSGDYLSKIADEQDVDGGWKKLYADNREA
                     VGSDPSLIHPGLKLSIDGQAAKPSAPSSAQSQKPAQKSAEKPAEKTAAKPAQKSTDAEK
                     ASSSDTGSQSTGTTSGYTSPVAGGTVGTPYHQSGSMWSSGYHTGTDFVVPTGTSLKAVG
                     AGTVVSAGWGGAYGNQVVIQLADGHYAQYAHLSSLSVSTGQSVTAGQQVGLSGATGNVT
                     GPHLHFEIRTTPDYGSDIDPLAFLRSHGVSV"
     misc_feature    complement(26291..26301)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    complement(26379..26391)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    26460..26479
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.46"
                     /tool="antismash"
ORIGIN
        1 gctctccccg gtgctcgccg tggaggtcgc cgtcgggccc gagtgggtgc gggtggccgt
       61 ggaggacgac cacccctacc gcccgaccgc cctggagacc gaccacggcc gcaccggtgg
      121 gcgcggcctg ctcctggtcc gcgagacgac ccgcgaggcg ggcggggcct gcgacgtggc
      181 ccacaccgcg agcggcggca aggtgatctg ggcggccctg ccgctcaagc acgccccgcg
      241 ctagacgcgg cgggtccggc agcaggcggc gggcccggcg ccggaacgtc cctcaccagc
      301 ccgcggacgt gcccgtcagt tcgcggacgg ccggccgggc cgcgtccagc accgtcatga
      361 accacgccga gaaggtgtcc tgcgcgtgcc gctcggtcag ctcggccggg gacacgaagg
      421 ccgtccccgc cacttcctcc gggtccgggc gcagctcggc ctgcaccaga ccgacgaaga
      481 ggtggttgta ctcctgctcg accagcccgg aggccgggtc gggatggttg tagcgcaccg
      541 tgccggcctc ggcgagcagg gagggcgaca cccccagctc ctcgaacgtc cgccgggccg
      601 ccgccgcgaa cggcgcctcg ccggggtagg ggtgaccgca gcaggtgttg gaccacacgc
      661 cgggggagtg gtacttgccc agcgcccgct gctggatcag cagccgcccc cgctcgtcga
      721 agaggaacac ggagaaggcg cggtgcagcc gccccggcgg ctggtgcgcg gagagcttct
      781 ccgcggtgcc gatcgtcacg ccgttctcgt cgaccagttc cagcaaaatg gcttctgcgg
      841 tgccgttcga cgagctgggc gtcgcggtgg caggagtgat cggcataccc atccttcaca
      901 tcggtcctcg cgccccaagt gtgccgtacg aatccggcac tctcggcact tcccggcaca
      961 cccgcatgtc ccgcctgccc gtgcgggcac cgggggcggc cggtcggaca ccgagcaggg
     1021 gtccgagggt gcaccgttcc cgagggcgcg ccccgggaat cgtccggtcc gcgtctcctc
     1081 cagtggtgcg gcggcggaac ggagcgttca gcggcgcgtt ccggtgcgtg cgcgcccccg
     1141 ggccgtccgt cgcgtcacgg gctcagcggc acagtcgcgc ctcgtgctcc gcgtgaccgc
     1201 tgggctccag ctggaacgtg cagtgctcca cgtcgaagtg gtcgcccaga cagccctgca
     1261 actcgtggag catcttctcg tggccgatcg cgctcagcgc ttcgccgtcc accaccacgt
     1321 gcgccgacag cacgggcatg ccggaggtaa tggtccaggc gtgcaggtcg tgcacgtcct
     1381 cgaccccgtc gagggccagt atgtgggcgc gcacctccgc gatgtccacg cccttgggag
     1441 ccgcctcgag cagcacgtcc agggtctcgc gcagcaaccg caaggttcgc ggcacgatca
     1501 tcagaccgat cagcagcgac gcgatcgggt cggcgggctg ccagccggtg gccaggatca
     1561 ccagcgccga gacgatcacc gccagggagc ccagcgcgtc ggccgccacc tccaggaagg
     1621 cgccccgcac gttcaggctc tccttctggc cgcgcatcag cagcgacagc gacaccatgt
     1681 tcgccaccag accgatcgcg ccgaagacga cggtcgggcc ggccgcggtg tcggccggcg
     1741 tgacgaatcg gtcgatcgcc tcgtacagga cgtaaccgcc gaccccgagc agcagcaggc
     1801 agttggccag ggcggcgagg atctcggcgc gggcgtagcc gaaggtgcgc cggtcgctcg
     1861 gcggtcggct cgcgaagtgc acggccagca gggccatgcc gaggcccagg gcatcggtcg
     1921 ccatgtgcgc ggcgtcggcg atcagggcga gggagtcggc gaccagaccg ccgacgatct
     1981 cgacgaccat gacggtgagg gtgatcgaca gcgccacgcg cagcctgccc cggtacgcgg
     2041 cggtcgccgt cccgccggcg tgccccccgt gcgcgtgccc gtgatcgtgc ccagccccca
     2101 tgagaaagcc gcctcctcgt gtgtaccggc gtccggcgac ccggcgcccg gatgccagtc
     2161 aactacgggt agggggtatc gggcaacgcg gcactgaaca ccgttgtcat gtgccctgac
     2221 ctgcggaaac gtttcgcagg tcagagtgtt gcgaggatgc ggagggtgcg gcttccgccg
     2281 tcagggggac cggtccgacg gggctcgtcc tgaccctgtg cgaacaacgg cggacactgt
     2341 gcgatgtccg cgatgcccgg tctgggggcg cggtttgtcg ggcgggcccc gaatccacga
     2401 tgatgatcgc ggcaaaggcg ggagcaagtg gcgtcgaccg accgtcaaac gggcggtgaa
     2461 cacggcgttc ccggcatccg ataccctctg ccgacatgcc gcccgggtgc cccaggcacg
     2521 ggcgtcccac catgcacagg cccggcgtcc aggcgccggc accagggagt gagttcggtt
     2581 gccgaccgcc atcctcaccg gtcagccggt cccgggttcc tcgatcgaga gcgagctgcg
     2641 gtccctgggc ttcgacgtgc acctcgcggc cggggccgcg gagaccgaga ccctcctcgc
     2701 ccgggtcccc ggcgaggagc gggtcgccgt cgtcgacgcc cgtttcgtgg gccacccgca
     2761 cgcgctgcgc ctcggcctca ccgacccccg cttcccgctc gccgcgatcc cgggcgcggt
     2821 gaccgcccag ccggccgccc gccagacgct gacccgcgcg atggcccgcg agaattccac
     2881 gggcggcggc accgccgtgg acgtcgacag cctcgccgac cggatcaccg ccgccctcga
     2941 cgccgacggc gccggggtgc accggcccga actcggcagc ctcgtggccg ccgttcccgc
     3001 cgacccgcag gcccgcaacg aggcgcggca ggccgtcgcc gccgtcgacg acgaggccgt
     3061 acgcctgaag tcggcggtca aggcccgcga cggcttcgtc accacccact tcatcagccc
     3121 ctactcccgc tacatcgccc gctggtgcgc gcgccgcggc ctgaccccca accaggtcac
     3181 caccgcctcg ctgatcaccg cgctcatagc ggccggctgc gcggccaccg gcacccgcgg
     3241 cggcttcgtc gccgccggcg tcctgctcat cgcctccttc gtcctcgact gcaccgacgg
     3301 acagctcgcc cggtactccc tccagtactc cacgctcggt gcctggctcg acgccacctt
     3361 cgaccgggcc aaggagtacg cctactacgc gggcctcgcc ctcggagcgg cccgcggcgg
     3421 cgacgacgtg tgggccctgg ccctcggcgc gatggtgctc cagacctgcc ggcacgtcgt
     3481 cgacttctcc ttcaacgagg ccaatcacga cgcctcggcc aacaccagcc ccaccgccgc
     3541 cctctccgac aagctcgaca gcgtcggctg gacggtgtgg ctgcgccgca tgatcgtgct
     3601 gcccatcggc gaacgctggg ccatgatcgc cgtcctgacc gcgctcacca cgccccggat
     3661 caccttctac gcgctgctga tcggctgcgc gttcgccgcg acgtacacca ccgcgggccg
     3721 tgtcctgcgc tcgctgaccc gcaaggccac ccgcaccgac cgggccgcga aggcgctggc
     3781 cgacctggcc gactccggtc cgctcgccga ggccggcgcc aagggcctgc gcaccgccgc
     3841 ccgccggctg cccggcttcg ccacccccgc cgtcgccctc ctcggcggtg ccgccgtcgt
     3901 cgccaccgcc gcgctcaccg acttcggcgg tccctggccg ctcgtcgccg cgctcgggta
     3961 cgtgctgacc tccgcgctcg ccgtcgcccg ccccctcaag ggcgccctcg actggctggt
     4021 ccccccgttc ttccgggccg ccgagtacct caccgtcctg ttcctggccg cgaaggccga
     4081 cgtgaacggg gcccttccgg cggctttcgg gctggtggcc gcggtcgcct accatcacta
     4141 cgacacggtc taccgcatcc gtggcgacgc gggcgcaccg ccgcagtggc tggtgcggac
     4201 ggtcgggggg cacgagggcc gcacgctggt gatcaccctg ctggccgtgc tcctcaccgc
     4261 cgcacagttc aaggtcgcgc tcacggtcct cgccgtggtt gtggcactcg tggtgctcgt
     4321 cgagagcatc cgcttctggg tcgccgccca ccaggtcggc gcacccgccg tacacgacga
     4381 aggagaaccc gcatgatcgg cctcgtgctg gcggccggcg ccggacgccg tctgcgcccc
     4441 tacaccgaca ccctgcccaa ggcactggtc ccggtcggcc ccgagggcgc ggaggacagc
     4501 atcacggtcc tcgacctgac gctggcgaac ttcgccgagg tcggtctgac ggaggtcggg
     4561 atcatcgtcg gctaccgcaa ggaggccgtg tacgaccgtc aggcggagct ggagcagaag
     4621 tacggcgtca agctcaccct catcgacaac gacaaggccg aggagtggaa caacgcctac
     4681 tccctgtggt gcggccgtga cgccctcaag gacggcgtga tcctcgccaa cggcgacacc
     4741 gtgcacccgg tctccgtcga gaagaccctg ctcgccgccc gtggcgacgg caagaagatc
     4801 atcctcgccc tcgacacggt gaagaacctc gccgacgagg agatgaaggt cgtcgtcgac
     4861 cccgacaagg gcgtgcagcg catcaccaag ctgatggacc cggccgacgc gaccggcgag
     4921 tacatcggcg tcaccctcat cgagggcgag gccgccgcgg agctggccga cgcgctgaag
     4981 accaccttcg agcgcgaccc gcagctctac tacgaggacg gctaccagga gctggtcaac
     5041 cgcggcttca aggtcgacgt ggcgccgatc ggcgacgtca agtgggtcga gatcgacaac
     5101 cacgacgacc tcgccaaggg cagggagatc gcgtgccagt actgacgagg ctcatcccgt
     5161 cgccggtcgt cgtggacatc cgcgcgggtg ccctcgacga cctgggatgc gtactcgccg
     5221 acgagcgcat ctcccactcg ggcaagctcg ccgtcgccgt cagcggcggc tccggcgccc
     5281 ggctgcgcga ccgcgtcgcc ccgtccctgc ccggcgccga ctggttcgag gtcggcggcg
     5341 gcaccctgga cgacgcgatc aagctggccg gcgccatgaa gggcggccac tacgacgcgg
     5401 tcgtcggcct cggcggcggc aagatcatcg actgcgccaa gttcgcggcc gcgcgcatcg
     5461 gccttccgct ggtcgccgtg cccaccaacc tcgcgcacga cgggctgtgc tccccggtcg
     5521 ccaccctcga caacgacgcg ggccgcggct cctacggtgt gccgaacccg atcgccgtcg
     5581 tcatcgacct ggacgtcatc cgcgcggcac cggcccgctt cgtacgcgcc ggcatcggcg
     5641 acgccgtctc caacgtctcc gcgatcgcgg actgggagct ggccaaccgg gtcaagggcg
     5701 agaagatcga cggcctggcc gccgcgatgg cccgccaggc cggcgaggcc gtcctgcgcc
     5761 accccggcgg catcggcgac aacgacttcc tccaggtgct ggccgaggcg ctggtgctca
     5821 gcggcatcgc catgtcggtc tccggcgact cgcggccctc ctcgggcgcc tgccacgaga
     5881 tcaaccacgc cttcgacctc ctcttccccg agcgcgcggc cgcccacggc gagcagtgcg
     5941 gcctgggcgc ggccttcgcg atgtacctgc gcggggccca cgaggagtcc gccaacatgg
     6001 cccgggtcct gcggcggcac gggctgccgg tgctgcccga ggagatcggg ttcactcccg
     6061 aggagttctt ccgggccgtg gagttcgcac cccagacgcg gcccggccgc tacacgatcc
     6121 tcgagcacct cgacctcacc accgaccaga tcaaggacct gtacgccgac tatgtcaagg
     6181 ccatcggtag ctgaactacg cccggtcgtc catcccgcgg gagtcaagga ccggcgcagc
     6241 ggtgagcact gggcgggacg cctctacatg cgcgaggtct cgctgcggat cgaccgctat
     6301 ctggtgaaca ccaggatcac gcccaaccag ctcacgtacc tgatgaccgt ctgcggcgtg
     6361 ctggcggccc cggcgctgct cgtgccgggc atctggggcg ccgtgctcgg cgtggtcgcg
     6421 gtccagctgt acctgctcct cgactgcgtg gacggcgaga tcgcgcgctg gcgcaagcag
     6481 tactcgctcg gcggggtcta cctggaccgc gtcggcgcct acctgaccga cgccgcggtc
     6541 ctggtcggcc tcggcctgcg cgccgccgac atctggggca ccggccggat cgactggctg
     6601 tgggccttcc tcggcaccct ggccgcgctc ggcgcgatcc tgatcaaggc ggagacggac
     6661 ctggtgggcg tcgcccggca ccagaacggg atgccgccgg tcaaggaggc cgcctccgag
     6721 atccgctcct ccggcatggc gctggcccgc cgggccgccg gcgcgctcaa gttccaccgg
     6781 ctgatcctcg gcatcgaggc gaccctgctg atcctggtcc tcgcgatcgt cgaccaggcg
     6841 cgcggcgacc tgttcttcac ccgcctcggc accgccgtgc tcgccggcat cgcgctgctg
     6901 cagaccctgc tgcacctggt gtccatcctc gcctccagca ggctgaagtg agcgcgcccg
     6961 tgaaggtcgg cgccgtcgtc atcacgatgg gcaaccgccc cgaggagctg cgcgccctgc
     7021 tcgactcggt cgcgaagcag gacggcgacc cggtccaggt ggtcgtggtc ggcaacggct
     7081 cgcccgtccc ggaggtgccc gaaggcgtgc gcaccgtcga gatgcccgag aacctgggca
     7141 tccccggcgg ccgcaacgtc ggcatcgagg ccttcggccc cggcggcagc gacgtcgaca
     7201 tcctgctctt cctcgacgac gacggactgc tcgcccgcac cgacaccgcc gagctgtgcc
     7261 gcgaggcgtt cgcggccgac gacgagctgg gcatcatcag cttccgcatc gccgacccgg
     7321 acaccggcga gacccagcgc cggcacgtcc cgcggctgcg cgcctccgac ccgatgcgct
     7381 cctcccgggt caccaccttc ctcggcggcg ccaacgcggt gcgcacccgc gtcctcaccc
     7441 aggtcggcgg gctgccggac gccttcttct acgcccacga ggagaccgac ctggcctggc
     7501 gggccctcga cgcgggctgg atgatcgact accggtccga catggtgctg aaccacccca
     7561 cgaccgcgcc gtcccggcac gcggtctacc accgcatggt cgcccgcaac cgcgtctggc
     7621 tcgcccgccg caacctcccc gcgctgctgg tcccggtcta cctcggcgtc tggatggccc
     7681 tcacgctgct gcgccggccg tcgcgacccg cgctgaaggc gtggttcggc ggcttccgcg
     7741 agggctgggc caccccgtgc ggtccccgtc ggcccatgcg gtggcgtacg gtgtggcgcc
     7801 tgacccggct gggccggccc ccggtgatct gacaagctcg tacccgagag tgttccggcc
     7861 ccgaacgggg ccaccaggtc catgccaggc ccgcgaggcc gagcattttc gaagacgaaa
     7921 gtttccacca gtgagtgaga caacgcacga cggcacggtc gccatgacca agcccgtgtc
     7981 gcccgacgag ggcctcacac cggcccggct cgccgccaag tacgggctgt ccgtgagcgg
     8041 cgcccgaccg agcctcaagg agtacgtccg ccagctctgg gggcggcggc acttcatcct
     8101 cgccttctcc caggcgaagc tgaccgccca gtacagccag gccaagctcg gccagctgtg
     8161 gcaggtggcc acgccgctgc tgaacgcgct cgtctacttc ctgatcttcg gcctgatcct
     8221 cgacgcgggc cggggcatgg agaaggacgt ctacatcccg ttcctggtga ccggtgtgtt
     8281 cgtcttcacc ttcacccagt cctcggcgat ggcgggcgtg cgcgccatcg ccggcaacct
     8341 cgggctggtg cgggcgctgc acttcccgcg ggcctcgctg cccgtctcct tcgccctcca
     8401 gcagctccag cagctgctgg cctcgatgat cgtgctgttc ctggtggtcg tcggcttcgg
     8461 cagctacccc tcgctgtcct ggctgctggt cctcccggtg ctggtcctgc agttcctgtt
     8521 caacacgggt ctcgcgctgg tcgtcgcccg gatgggggcc aagacgccgg acctggccca
     8581 gctgatgccg ttcatcatgc gcacctggat gtacgcctcg ggcgtgatgt tctccatccc
     8641 gatcatgctg aaggacaagc cggactggat cgccgacgtg ctccagtgga acccggccgc
     8701 cgtctacatg gacctgatgc gcttcgcgct gatcgacggg tacggctccg agaacctgcc
     8761 gccgcacgtg tgggcggtcg cactcggctg ggccgtggtc ctcgccgtgg gcggcttcgt
     8821 gtacttctgg aaggcggagg agaggtacgg ccgtggctga acagcagcag gaccagcggg
     8881 tgccgacggt catcgcggac gaggtgcaca tcgtctaccg cgtcaacggc gccaagaccg
     8941 gcaagggcag cgcgacagcc gccctgagcc gcatactcaa gaagggttcc gacgacgcga
     9001 agcggggcgt gcgcaaggtg cacgccgtgc gcggcgtctc cttcaccgcc taccggggcg
     9061 aggccatcgg cctgatcggc tccaacggct ccgggaagtc gaccctgctg cgcgccatcg
     9121 ccgggctgct gcccgccgag cgcggcaagg tctacacgga cgggcagccc tccctgctcg
     9181 gcgtgaacgc ggccctgatg aacgacctga ccggcgagcg gaacgtcatc ctcggcggcc
     9241 tggccatggg catgtcccgc gagcagatca aggagcgcta ccaggagatc gtcgacttct
     9301 ccgggatcaa cgagaagggc gacttcatca ccctgccgat gcgcacgtac tcctccggca
     9361 tggccgcccg gctgcggttc tccatcgccg ccgccaagga ccacgacgtc ctgatgatcg
     9421 acgaggcgct ggccaccggc gaccgcaagt tccagacccg ctccgaggag cgcatccggg
     9481 agctgaagaa gcaggccggc accatcttcc tggtcagcca caacaacaag tccatccgtg
     9541 acacctgcaa ccgggtcctg tggctggagc gcggcgagct gcgcatggac ggcccgaccg
     9601 acgaggtgct caaggagtac gagaagttca cgggcaagta gcccgacacg ccagggcctc
     9661 gccggaactg ttccggcgag gccccgcgtc tgcaaaggaa gcgtcaactc ctggcgttct
     9721 caggaatctt gaagtcaatc ggtgtgttgt tgtgatgcgc tgtgcacccc gacgcacgcc
     9781 cgtgagttgt acaacgtaag ctgtaccggt cccgaaacgc ggcacatggg gcgataatgc
     9841 ccgacaccct ggagcgggcc tgccgcgcgg gtggcggggc ggcgtgtccg aaatagtgtg
     9901 tattgggtcg gcagtgtaga acgggagatg tgacggcaat ggcgacggaa actccccagc
     9961 tccgcgaagc gtgcgccgtc cccgcccagg gcagcccgcg atgacggtca ccgacacggc
    10021 gcacgccgtc gacccggagc gcggcaccct cgccaaggcc gccgacgaga acttccccgt
    10081 cgcccccttc ttcctgcccc gcgcctggcg caccgacctc atggccgtct acggcttcgc
    10141 ccgtctcgtc gacgacatcg gcgacggcga cctcgccccg ggcggagcgg acgcccgtct
    10201 gctcggcgtc cccgaggacc gcgccgacga ccgactgctg atgctggacg ccttcgaggc
    10261 ggacctgcat cgtgtcttcg acggctccga cggctccgac ggtgcgcccc gccacccgct
    10321 gctgcgccgt ctggtgccca ccgtgcgccg ccgcgcgctg acccccgagc ccttcctcgg
    10381 cctgatcgcc gccaaccggc aggaccagct ggtcgcacgg tacgagacct acgacgacct
    10441 cctcgcctac tgcgagctgt ccgccaaccc cgtcggccgt ctcgtcctcg ccgtcaccgg
    10501 cacctcgacc cccgaacgga tccgccgctc cgacgagatc tgcaccgccc tgcagatcgt
    10561 cgagcacctc caggacgtcg ccgaggacct cggacgggac cggatctacc tgcccgccga
    10621 ggacatgaag cgcttccacg tccaggaggc ggacctcgcc gcgcccagcg cgaacgcctc
    10681 cgtgcgcgcg ctgatcgcct acgaggccgc ccgcgcccgc gacctgctga atgaaggcgc
    10741 ccccctggtg ggtagcgtcc acggcaggct gcgactgctc ctggcaggct tcgtggcggg
    10801 tggcagggcg gcgctgaacg cgatcgccgc ggcggatcac gacgtacttc ccggcccgcc
    10861 caagtcaggc aaggtccact tgctgcgcga ggcgggcgtg gtcctgcgag gagaggggtg
    10921 atcgggtccg tggagtcgtc agcgaacatg ccggcaccgg tgctcgccgc ctacagctac
    10981 tgcgaggccg tcaccggtca gcaggcacgc aacttcgcct acggcatccg gctgctgccc
    11041 acgcccaagc ggcgggcgat gtccgcgctg tacgcgttct cgcgccgggt cgacgacatc
    11101 ggcgacggag tgctggcgga cgacgtcaag gtcacccggc tggacgagac ccgggccgtg
    11161 ctctcccgga tccaggacgg cgcggtcgag gaggacgaca ccgacccggt cgccgtcgcc
    11221 ctcgccgacg cggcccggcg gtttcccatc ccgctcggcg gcctcgacga gctgatcgac
    11281 ggcgtccaga tggacctgcg cggcgagacc tacgagacct gggacgacct gaaggtctac
    11341 tgccgctgcg tggcgggcgc catcggacgc ctctcgctcg gcgtcttcgg caccgaaccg
    11401 ggggcgcgcg gcgccgagcg cgcgcccgag tatgccgaca cgctcgggct cgcgctgcag
    11461 ctcaccaaca tcctgcgcga cgtccgggag gacgccgagg gcgggcgcac ctacctgccc
    11521 gccgacgacc tcgccaagtt cggctgtgcg gccggattca acggcccgac accacccgag
    11581 ggctccgact tcgcgggcct cgtgcacttc gaagtgcgtc gggcccgcgc ccttttcgcc
    11641 gagggctacc ggctgctgcc catgctcgac cggcgcagcg gcgcctgcgt ggccgccatg
    11701 gccggcatct accgccgtct cctggaccgc atcgagcgcg accccgaggc cgtactgcgc
    11761 ggccgggtct ccctgccggg acgcgagaag gcgtacgtcg ccgtgcgcgg cctgtccggc
    11821 ctcgacgccc ggcacgtcac ccggcggacc gtcaggaggc gcgcctgatg gacacaccgg
    11881 gcacactcga cacccgggac ccgtacaaaa ccggcggcgg gcagtggcgg gcaaccctgc
    11941 ggtggcggtc ggcgtccctg actgagacgg tcagccgtac gccgttcaaa caccgcggcg
    12001 gccggacagg gaagggcgca ccatgacgca gggcaagggc acgcgcgagg gcggagtgct
    12061 cgcggacgtc tcggccctcg gccccggcgg gcatgccgtc gtggtcggcg gcggactcgc
    12121 gggggtcacc accgcgctgg cactggcgga cgccggtgtg cgcgtcaccc tgctcgaagg
    12181 acgcccccgg ctcggcgggc tcgccttctc cttccagcgc ggcgacctca ccgtcgacaa
    12241 cggccagcac gtgtacctgc gctgctgcac cgcctaccgg tggttcctcg accggatcgg
    12301 cggagccgcg ctcgcaccgg tgcaggaacg tctcgacgtg cccgtggtcg acctggcgag
    12361 gagcgagggc aaccggctcg gcagactgcg gcgcgacgcg ctgcccgtcc ccctgcatct
    12421 ggggcgcagc ctcgcgacct acccgcacct ctccctcgcc gaacgcgcct cggtgggacg
    12481 cgccgcgctc gcgctcaagg ggctcgacct cgccgatccg agcctggaca cccaggactt
    12541 cggcagctgg ctgaccgcgc acggtcagtc ggcgcgtgcc gtcgaggccc tgtgggacct
    12601 ggtcggggtc gccaccctca acgcggtcgc gggcgacgcc tcgctggggc tcgccgcgat
    12661 ggtgttcaag accggtctgc tgtccgaccc gggagcggcc gacatcgggt gggcccgtgt
    12721 cccgctgggc gaactgcacg accggctggc ccgcaaggcg ctcgactccg cgggcgtccg
    12781 taccgaggtc cgtacacgcg tcacctccgt ctccgtaaac gagaacggcg gctggagcgt
    12841 tcaggttccc ggcgagacgc tcgaagcgga cgccgtcgtc ctcgccgtac cccagcgcga
    12901 ggcccacgac ctgctgccgg acggtgcgct ggacgccccg gaaaatcttc tgcggatcgg
    12961 caccgcgccg atcctcaaca tccacgtgat ctacgaccgc aaggtgctcg gcacgccgtt
    13021 cctcacggcc ctcggcaccc cggtccagtg ggtgttcgac cgcaccgagg cctccgggct
    13081 gaaggagggt cagtacctgg cgctgtccca gtcgaccgcg cagaacgaca tcgacgagcc
    13141 cgtggccgtg ctgcgcgagc ggtacctgcc cgaactggag cggctgctgc cgcgcacccg
    13201 gggtgccgag gtgaaggact tcttcgtgac cagggagcgc accgccacgt tcgcccccgc
    13261 ccccggcgtc gggcgcctca ggcccggcgc ccgcaccaag gcacccggcc tctacctggc
    13321 cggagcgtgg accgccaccg ggtggcccgc gaccatggag agtgcggttc gcagcggtgt
    13381 cggggcggcg gccgccgcgc tcggcgccct gggccggtcc cgcggcctcc ttcccgattt
    13441 cttcgaggag gcggcgtgaa agccgatccg cgcgggaccg gctcccgcac tcccggcacc
    13501 gcaactggag gaaagactgt gcccactgtg cccccggccc cgacggccga tcgacggacc
    13561 acggtggacg tgaccgcgct tctggagcgc ggccggaccc tggccacgcc ggtcctgcgg
    13621 gcggcggtcg accgcctggc ccctcccatg gacaccgtcg ccgcctacca cttcggctgg
    13681 atcgacgccc agggcaaccc cgcggacggc gacggcggca aggccgtccg ccccgcgctc
    13741 gccgtgctct ccgccgaggt caccggcgcc gcccccgagg tcggtgtgcc cggcgcggtg
    13801 gctgtggaac tggtgcacaa cttctccctc ctgcacgacg acctgatgga cggcgacgag
    13861 cagcgccgcc accgcgacac cgtctggaag gtgcacggcc ccgcccaggc catcctggtc
    13921 ggcgacgccc tgttcgccct cgccaacgag gtgctgctcg aactgggcac cgtcgaggcc
    13981 gggcgggcca cccgccgcct gaccaaggcc agccgctccc tgatcgacgg tcaggcccag
    14041 gacatctcct acgagcaccg cgaccgcgtc agcgtcgagg agtgcctgga gatggagggc
    14101 aacaagaccg gtgccctgct cgcctgcgcc agctccatcg gagcggtgct cggcggcgcc
    14161 gacgaacgca ccgccgacac cctcgagaag tacggctacc acctcggtct cgccttccag
    14221 gccgtcgacg acctgctcgg catctggggc gacccggacg ccaccggcaa gcagacctgg
    14281 agcgacctgc gccagcgcaa gaagtcgctg ccggtcgtcg ccgccctcgc ggccggcggg
    14341 gccgcctccg agcggctcgg cgagatcctc acggccgacg ccaaggccag cgacttcgcg
    14401 aacttctccg aggaggagtt cgcggcccgc gccgccctca tcgaggaagc gggcgggcgg
    14461 gagtggaccg ccgacgaggc gcgtcgccag cacaccatcg ccatcgaagc cctcgacgcc
    14521 gtcgacatgc ccgaccgggt gcgggaccgg ttcacggccc tcgcggactt cgtcgtcgta
    14581 cgaaagagat gatcattatc ggtcgaatag ccctcgcgta gtcgccggcc ggtgtcgtgg
    14641 agacacgagc accggccgac ggcggaccca gcagacgcac cacatgcaca ctgcacgaag
    14701 gggaagccat gacagcgacg accgacggaa gcaccggagc ctccctgcgg cccctggcag
    14761 cctcggccag cgacaccgac atcacgatcc ccgccgcggc ggccggggta cccgaagccg
    14821 ccgcccgcgc cacccggcgt gccaccgact tcctgctcgc caagcaggac gccgagggct
    14881 ggtggaaggg cgacctcgag acgaacgtca cgatggacgc cgaggacctg ctcctgcgtc
    14941 agttcctggg catccaggac gaggagacca cccgcgccgc cgcgctgttc attcgcggcg
    15001 agcagcgcga ggacggcacc tgggccacct tctacggcgg ccccggcgaa ctgtccacga
    15061 ccatcgaggc ctacgtcgcc ctccgcctgg ccggcgactc acccgaggcg ccccacatgg
    15121 cgcgggccgc ggagtggatc aggtcccgcg gcggcatcgc ctccgcccgg gtcttcaccc
    15181 ggatctggct ggccctgttc ggctggtgga agtgggacga cctgcccgaa ctcccgccgg
    15241 agctgatcta cttccccacc tgggtcccgc tcaacatcta cgacttcggc tgctgggccc
    15301 ggcagaccat cgtgccgctc accatcgtct ccgcgaagcg gccggtgcgt cccgcgccgt
    15361 tcccgctgga cgaactgcac accgacccgg cccgccccaa cccgccacgc cccctggcac
    15421 ccgtggccag ctgggacggc gccttccagc gcatcgacaa ggccctgcac gcctaccgca
    15481 aggtcgcccc gcgccggctg cgccgggccg cgatgaacag cgccgcccgc tggatcatcg
    15541 agcggcagga gaacgacggc tgctggggcg gcatccagcc gcctgcggtc tactcggtca
    15601 tcgccctcta cctgctcggc tacgacctcg aacaccccgt gatgcgcgcg ggactggagt
    15661 cgctggaccg tttcgccgtc tggcgcgagg acggcgcccg gatgatcgag gcctgccagt
    15721 ccccggtgtg ggacacctgc ctggccacca tcgcgctggc cgacgcgggc gtgcccgagg
    15781 accacccgca gctggtgaag gcctcggact ggatgctcgg cgaacagatc gtgcgccccg
    15841 gcgactggtc ggtgaagcgc cccggactcc cgcccggcgg ctgggcgttc gagttccaca
    15901 acgacaacta ccccgacatc gacgacaccg ccgaggtggt cctcgccctg cgccgggtca
    15961 ggcaccacga cccggaacgg gtggagaagg cgatcgggcg cggggtgcgc tggaacctcg
    16021 gcatgcagtc gaagaacggc gcctggggcg ccttcgacgt cgacaacacc agcgccttcc
    16081 ccaaccggct gccgttctgc gacttcggcg aggtcatcga cccgccgtcc gcggacgtca
    16141 ccgcgcacgt cgtcgagatg ctcgccgtcg agggcctcgc ccacgacccg cgcacccgcc
    16201 gcggcatcca gtggctgctc gacgcccagg aggcggacgg ttcgtggttc ggccgctggg
    16261 gcgtcaacta cgtctacggc accggttccg tgatccccgc gctgaccgcg gccggactgc
    16321 ccacctcgca cccggccatc cgccgggctg tgcgctggct ggagtccgtc cagaacgagg
    16381 acggcggctg gggcgaggac ctgcgctcct accgctacgt ccgggagtgg agcggccggg
    16441 gcgcctcgac cgcctcgcag accggctggg cgctgatggc cctgctggcg gcgggggagc
    16501 gggactccaa agccgtggag cgcggcgtcg catggctcgc ggccacccag cgggaggacg
    16561 gctcctggga cgagccctac ttcacgggca ccggcttccc gtgggacttc tccatcaact
    16621 acaacctcta ccgccaggtc ttcccgctca ccgctctcgg ccggtacgtc cacggggagc
    16681 ccttcgccaa gaagccccgc gcggccgacg cccccgccga agccgccccg gccgaggtga
    16741 agggcagctg atgaccccgc agaccggccc gtccccgctg ctgatcgcct gcgcgctcgg
    16801 catcgagcac ctcgccctgc gcaccggcga ccgcgccggc gccggcgggc cggtcaccgt
    16861 cctgcgcacc ggcatgggtc ccagggcggc cgaacgctcg gtcacccggg tcctcgccga
    16921 cccggcactc gagggcgccg ccgtgctcgc cacgggcttc tgcgccggac tctcgcccgg
    16981 catgcacccc ggtgacctgg tcgtcgccga ggagacccgg gacccgcgct ccaccgtccc
    17041 ctgcgtcgcg accgaccggc tcgtcaagga actcgcgcga gccgtccccg ggcgcaccgt
    17101 ccacaccggg ccgctgaccg gctcggacca cgtcgtccgc ggccccgaac gcgccgacct
    17161 gctcgcgacc ggcgcgatcg ccgtggacat ggagtccgcg gccacgctcc tgagcgccgt
    17221 ccgcacgggc ccgcgcccgg ttgcggccgt ccgagtggtc gtggacgctc cagaacacga
    17281 actcgtccgg atcggcaccg tgcgcggtgg aatatcggcc ttccgtgttc ttcgatccgt
    17341 tcttcccgca tttttcgaat ggcaccgttc tttgttgctt ccccggaggt gagcccagat
    17401 ggccatgccg ctgcgccagt ccatcaaggt cgctacatac ctggccgaac agaagattcg
    17461 ccgacgggac aagttcccgc tcatcgtgga gctggaaccg ctcttcgcct gcaacctggc
    17521 gtgcgaggga tgcggcaaga tccagcaccc cgccggtgtg ctcaagcagc gcatgccggt
    17581 cgcacaggcc gtcggggcgg tgctggaatc gggcgcgccg atggtctcca tcgccggcgg
    17641 cgagcccctg atgcacccgc agatcgacga gatcgtccgg cagttggtgg ccaagcggaa
    17701 gtacgtcttc ctctgcacca acgccatgct catgcgcaag aagatggaca agttcaagcc
    17761 ctcgccgtac ttcgccttcg cggtgcacat cgacggactg cgcgagcggc acgacgagtc
    17821 cgtggcgaag gagggcgtgt tcgacgaggc cgtggaggcc atcaaggagg ccaagcggcg
    17881 cggcttccgg gtgaccacca actcgacctt cttcaacacc gacaccccgc agaccatcgt
    17941 cgaggtgctc aacttcctca acgacgacct caaggtcgac gagatgatga tctcgcccgc
    18001 ctacgcctac gagaaggcac ccgaccagga gcacttcctg ggcgtggagc agacccgcga
    18061 gctgttcaag aaggccttct cgggcggcaa ccgggcccgc tggcggctca accactcccc
    18121 gctgttcctc gacttcctcg agggcaaggt cgacttcccg tgcaccgcgt gggcgatccc
    18181 gaactactcc ctcttcggct ggcagcgccc ctgctacctg atgagcgacg gctacgtccc
    18241 gacgtaccgg gagctgatcg aggagaccga ctgggacaag tacggccgcg gcaaggaccc
    18301 gcgctgcgac aactgcatgg cgcactgcgg ctacgagccc accgccgtcc tggccaccat
    18361 gggctcgctc aaggagtccc tgcgcgccat gcgggagacg gtctccggga accgggagtg
    18421 acgtcgtgac cgccatcccc ttggggctcc ccggggtacc ggtccggccg atcgccgagc
    18481 ggcgcgtgtc gcggcggatc caggtcgggc cggtggcggt cgggggcggg gctccggtgt
    18541 cggtgcagtc gatgacgacc acccgtacgt ccgacatcgg ggccacgctc cagcagatcg
    18601 ccgagctgac ggcgtcgggc tgccagatcg tccgggtggc ctgccccacc caggacgacg
    18661 ccgacgcgct gcccgtcatc gcgaggaagt cgcagatccc ggtgatcgcg gacatccact
    18721 tccagcccaa gtacgtcttc gccgcgatcg aggccggctg cgcggcggtc cgggtgaacc
    18781 cgggcaacat caagcagttc gacgacaagg tcaaggagat cgccaaggcg gcgaaggacc
    18841 acggcacgcc catccgcatc ggtgtgaacg ccggctccct cgaccgccgc ctgctccaga
    18901 agtacggcag ggcgaccccc gaggccctcg ccgagtccgc cctctgggag gcgtcgctct
    18961 tcgaggagca cgacttccgc gacatcaaga tctcggtcaa gcacaacgac ccggtcgtca
    19021 tggtcgaggc ctaccgccag ctcgccgccc agtgcgacta cccgctgcac ctgggggtga
    19081 cggaggccgg gcccgcgttc cagggcacca tcaagtccgc cgtcgccttc ggcgcgctgc
    19141 tctcgcaggg catcggcgac accatccggg tgtcgctcag cgccccgccg gtcgaggaga
    19201 tcaaggtcgg catccagatc ctccagtcgc tggggctgag ggaacgccgg ctggagatcg
    19261 tctcctgccc gtcctgcggc cgcgcccagg tcgacgtcta caagctggcc gaggaggtca
    19321 ccgccgggct ggagggcatg gaggtgccgc tgcgcgtggc cgtcatgggc tgcgtcgtca
    19381 acggccccgg tgaggcccgc gaggcggacc tcggcgtcgc ctccggcaac ggcaaggggc
    19441 agatcttcgt caagggcgag gtcgtcaaga ccgtgcccga gtcgaagatc gtggagaccc
    19501 tcatcgagga ggcgatgagg atcgcggagc agatggagaa ggacggcgcc tcgggggcgc
    19561 cggccgtcac cgtgagctga aacgcggacc gaagggggcc cgagcgtgac gattctggag
    19621 aacatccggg gaccacgcga cctgaaggcg ctgtccgagg cggaactcgg tgaactgtcc
    19681 gacgagatac gtgacttcct ggtgcacgcg gtcgcccgca ccggcggtca cctcggaccc
    19741 aacctcggcg tggtggaact caccgtcgcc ctgcaccggg tcttcgagtc gccggacgac
    19801 cgcatcctgt gggacaccgg ccatcagagc tatgtgcaca aactcctgac cggacgtcag
    19861 gacttctcca agctgcggag caagggcggc ctgtccggct acccctcgcg cgaggagtcc
    19921 gcgcacgacg tcatcgagaa cagccacgcc tccaccgtcc tcggctgggc cgacggcctc
    19981 gccaaggccc gccaggtgca gggggagcgc agccacgtcg tcgccgtcat cggtgacggc
    20041 gcgctcaccg gcggcatggc ctgggaggcg ctgaacaaca tcgcggcggc cagggaccgg
    20101 ccactgatca tcgtcgtcaa cgacaacgaa cgctcgtacg cgccgaccat cggcggcctc
    20161 gccaaccacc tggcgaccct gcgcaccacc gacggctacg agcgggccct ggcctggggc
    20221 aaggacgtgc tccagcgcac gcccgtggtg ggccacaccg tctacgaggc cctgcacggc
    20281 gccaagaagg gcttcaagga cgccttcgcc ccgcaggggc tcttcgagga cctgggactg
    20341 aagtacctcg gtccgatcga cgggcacgac atcggcgccg tcgagtcggc gctccgccgc
    20401 gcgaagcgct tccacggccc ggtgctcgtg cactgcctca ccgagaaggg ccgcggctac
    20461 gagcccgccc tgcgcgacga ggaggaccac ttccacacgg tcggcgtgat ggacccgctc
    20521 acctgcgagc cgctcggccc ggcgggcggg ccgtcctgga cctccgtgtt cggtgaggag
    20581 atcgtccgga tcggcgagga gcgcgcggac gtggtggcga tcaccgcggc catgctgcac
    20641 ccggtcggtc tcgccccttt cgccgaacgg ttccccgacc gggtctggga cgtcggcatc
    20701 gccgagcagc acgccgccgt ctccgccgcc ggcctcgcca ccggcggact gcacccggtc
    20761 gtcgccgtct acgccacctt cctcaaccgc gccttcgacc agctcctgat ggacgtggcc
    20821 ctgcaccgct gcggcgtcac cttcgtcctg gaccgggccg gcgtcaccgg cgtcgacggc
    20881 gcctcgcaca acggcatgtg ggacatgtcc gtcctccagg tcgtccccgg actgcggatc
    20941 gccgccccgc gcgacgccga ccagctgcgc gcccagctgc gcgaggcggt cgccgtggac
    21001 gacgcgccga cgctgctgcg cttcccgaag gagtccgtcg gccccgccgt acccgccgtc
    21061 gaccggatcg gcggcctgga cgtcctgcac gccgccaacc ggtccgaggt gctgctcgtg
    21121 gcggtgggcg tgatggcacc cgtctgcctc ggggccgccg aactcctcga ggcccgcggc
    21181 atcggctgca ccgtcgtcga cccgcgctgg gtcaagccgg tcgacccggc gctcgcaccg
    21241 ctcgcggccc ggcaccggct ggtcgccgtg gtcgaggaca acagccgggc cgccggggtc
    21301 ggttccgcgg tggcgctggc gctcggcgac gccgaggtcg acgtccccgt gcgccgcttc
    21361 ggcatccccg agcagttcct cgcgcacgcc aagcgcgccg aggtgctcgc ggacatcggc
    21421 ctcaccccgg tcgacgtcgc cgggcggatc gccgcgagtc tggccctcgc cgagccggcc
    21481 ggggaccggg cgggtggacc ggcagtggaa cagcccggcg acggacggat gtccggcgac
    21541 ggacggatcg tcatgccagc gcaaggagag aactgaatga ccaaggagtt cgacctcgcc
    21601 gcgctcttgg ccgagcgcgg ggccgagcgg tacgagctgc acgccaggca cctcaaccac
    21661 cagctgccgc gcatgctgca caccatcggc ttcgacaagg tctacgagcg ggccgagggc
    21721 gcgcacttct gggacgcgga cggcaacgac tacctggaca tgctcgccgg gttcgcggtg
    21781 atgggcctgg gccgccacca cccggtcgtc cgcaaggcgc tgcacgacgt gctcgacgcc
    21841 tcgctcgccg acctgacccg cttcgactgc ccgccgctgc cgggcctgct ggccgagaag
    21901 ctgctctcct acagcccgca cctggaccgc gtcttcttcg gcaacagcgg caccgaggcc
    21961 gtcgagaccg cgctgaagtt cgcccggtac gcgaccggca gacagcggat cctgtactgc
    22021 ccgcacgcct tccacggact gacggccggc tccctctccg tcaacggaga ggacggcttc
    22081 cgcaagggct tcgcaccgct gctgcccgac accgccgtcc cgctcggcga cctcgacgcc
    22141 ctggcgcggg agctgaagaa gggcgacgtg gccgccctga tcgtggagcc ggtccagggc
    22201 aagggcgtgc acgaggcccc gcccggctac ctgctcgccg cgcaggagct gctgcaccgg
    22261 cacaaggcgc tgctgatcgc cgacgaggtg cagacgggcc tcggccggac cggcaagttc
    22321 tacgcctacc agcactcgga cggggtggag cccgacctgg tctgcgtggc caaggcgctg
    22381 tccggcggat acgtcccggt gggggccacc ctgggcaagg actggatctt ccagaaggtg
    22441 tactcctcga tggaccgcgt gcaggtccac tcggcgagct tcgggtccaa cgcacaggcc
    22501 atggccgccg ggctcgcggt gctgtcggtg atggagaacg aggagatcgt cgcgaacgcc
    22561 gcggcggtgg gggagcggct gaagtcccgg cttgcggagc tggtggaccg ctacgagctg
    22621 ctcgccgacg tccggggccg cggactgatg atcggcatcg agttcggccg gcccaggtcc
    22681 ctgaagctgc gcagccgctg gacgatgcta caggcggcgc ggaagggact gttcgcgcag
    22741 atggtggtcg tgccgctgct gcaacggcac cggatcctga cccaggtgtc cggcgaccac
    22801 ctggaggtga tcaagctgat cccgccgctg atcgtcgaca ccgacgacgc cgaccggttc
    22861 gtcgacgcct tcacggaggt gatggaggac gcgcaccatg gcggtggcct gatgtgggac
    22921 ttcgggaaga ccctggtcaa gcaggcggtg gccaaccgct gagcgcaccc tccgggtctt
    22981 ttgcctctga ggcaaggaat ttgcctggcg ggcaagattc gggctgaatg gaggcatgag
    23041 ctcctccgag accggccccg ccgagggggc ggtcgccgcc gtcgcgcccc agctgcgtga
    23101 gctgcggcgg cgggccgccc tcaccctgga ggccgccgcc cgcgccgcag ggctctcgcc
    23161 cgcccacctc tcccgcctgg agaccgggca gcgccagccc tcgctgccga tgctgctctc
    23221 cctcgcccgg gtctacggta cgaccgtcgc cgagctgctg ggcgagtcgg ccgcggaccg
    23281 ggacgccgtc gtgcgcgccg ccgacatgga acccaccgcc gcgggcggct ggacgtactg
    23341 gcgggccgga gcgccgggcc gcggcatgca ggccctgcgc gtccaggttc cgtacggctc
    23401 ccagggcgac gtcgtgcggg tgcaccccgg cgaggagtgg ctgcacgtcc tgcggggccg
    23461 gctgcgactg cgcctcgggg acaccgagca ccggctcacc gcgggggaca gcgcccactt
    23521 cgactcgatg accccgcacc ggatcgccgc gcaggacccc gacggggtcg agctgctgtt
    23581 cgtccacacc ctgctgcaga gcccgacggc cgccctgtgc ctcggcccga cccctggaga
    23641 gacgccatga gcaccatgca ggagaagttc ccgcgcgccc tgtgggtgcg gctgatcgtc
    23701 tacatcgccc tggggcacgt cttcggcggc ttcctctacc tgctgttcga ggtgggcgcc
    23761 aagtagcgcc gggcgcgggc gggtgggtca gtccagcatc cgctcgcgca gccgctcccg
    23821 ggtcgcggga gtgaggcgca ggccctgctc cagataggcg tcgacgccgc cccacgtctc
    23881 ctcgacggtc tcgaaggccg ccgccaggta ctcggcgcgc gcgtcgaaca gagggctgag
    23941 cagctccatg acctcggggg agtaggccga ggccgcggaa ccgctgcggc gcaccttgta
    24001 gcggcggtgc gcggcgttcg acttcaggta gtcctcgacg acggcctcgc gctcgacacc
    24061 cagggcgagc agcgtgacgg cgatcgacag gcccgcgcgg tcctttccgg cggcgcagtg
    24121 catcagggcc gggacgctgt cctcggcgag cgcgtgcagg atgcgggagt gctccgcggt
    24181 gcgctccgtg acgatcgcgc ggtaggagcc gatcatccgg tccgcggcct tgccgtcggc
    24241 caggatctcg cgcagctggt cgaggtcgcc gtcacggacc atcttccaga actcggcgcc
    24301 gtcggccggg tcgctcagcg gcaggttcac attgcgcacg cccggcaggt cgacgtccgg
    24361 gccctcgagc ttctggtcgg ccgcgttgcg gaagtcgaag atcgtgtgca ggcccagcga
    24421 ggccaggaac gcggcgtcct ccccggtggc gtgagccagg tgaccgctgc ggaacagcac
    24481 cccctgccgc acccgccgcc cgtccacggt cggcagtccg cccacgtccc ggaagttgcg
    24541 cacgccggtc agctcgggtt cggtcgacgg gacctgctgc gtcacggggg ctcctcccac
    24601 tccgccccgc cgccgctgct cgccggcggg ctccacccga cgatacggca tcacccgggc
    24661 gcgaaatgga gccccgaggg atattccggg ccgattagag ccttctgtcc gaattggtgg
    24721 cttaataaca actggccctg aaatggcgga gggtgaaggt gaggcgcgtg agcagcgtca
    24781 tatccgtgac cgtgcgttgc ccgtcatgtt cacgtaattc aactgtttct caaggggctt
    24841 taagcaaaag cgcgcgacgg aaatcgacgc agggttaccg gatattcccg taaaggatca
    24901 atcggaacac ctgccggggg aacccttcgc ttgtccctgt gcgtcttggt cccttacgtt
    24961 caccaccgat ccggacggac gcctaatcct gccgccgacc ggagcccgca ctcatcgacc
    25021 acccgtacac ggcaggagcg ggggacccac aggtagaact gcctgttccg gttcccggaa
    25081 cggcttgggg taaagccgcg ctccggcgcg gccgggcatc tccagcccgc acccgacagc
    25141 tcacctcgca ggcgccggag aggaattcac catgcccgcg aagggtaagc accgccgtac
    25201 cagggccatg cgcctgaccc gcaccatcgc cgtcgccggg accggtggcg ccgcgctcgc
    25261 gctcccgctg atgggtgccg ccgccgccaa cgccgctccc gcgcactccg tttccgagca
    25321 ggccgtgcag tccgttccgg cgtccgccaa gaaggccgcc gccgagaaga actccgactc
    25381 gcgcacctac accgtgaaga gcggcgacta cctctcgaag atcgccgacg agcaggacgt
    25441 cgacggcggc tggaagaagc tctacgcgga caaccgcgag gccgtcggtt ccgacccgtc
    25501 gctgatccac cccggtctca agctctcgat cgacggccag gccgccaagc cgtcggcgcc
    25561 gtcctccgcg cagtcgcaga agcccgcgca gaagtccgcc gagaagcctg cggagaagac
    25621 cgccgcgaag ccggcccaga agtcgacgga cgccgagaag gcctcctcct cggacaccgg
    25681 cagccagtcc acgggcacca ccagcggcta cacctccccc gtcgcgggcg gcaccgtcgg
    25741 caccccgtac caccagtccg gcagcatgtg gtccagcggc taccacaccg gcaccgactt
    25801 cgtcgtcccg accggcacct ccctcaaggc cgtcggcgcg ggcaccgtcg tctccgccgg
    25861 ctggggcggc gcgtacggca accaggtcgt catccagctc gccgacggcc actacgccca
    25921 gtacgcccac ctctcctcgc tctccgtctc caccggtcag tcggtgacgg cgggtcagca
    25981 ggtcggcctc tcgggtgcca ccggcaacgt gaccggcccg cacctgcact tcgagatccg
    26041 caccacgccg gactacggct cggacatcga cccgctggcg ttcctgcgct cgcacggcgt
    26101 ctccgtctga cgaccggttc cgcgcggccc ccgcgcaccg aaggccggac cccgatcccc
    26161 gggtccggcc ttcggcgtgt ccggacccgg tgcgcgcgcc gtacaggccc ctcgccgtat
    26221 tccggaattg acgaatactt taggcgtggc ctttctcacc gcccgtcaat cccttcctac
    26281 ggtcgcgtag gtcacattcc aaggtgaatc atgggccgat gtggcagacg attcgaagag
    26341 tgacagcaga gcagtgatcg ggtcgtacgt ggcggtgggg gacagcttca ccgagggcgt
    26401 cggcgacccc ggccccgacg gggcgttcgt cggctgggcc gaccggctcg ccgtactgct
    26461 cgcggaccgg cgccccgagg gcgacttcac gtacacgaac ctcgccgtgc gcggcaggct
    26521 cctcgaccag atcgtggcgg aacaggtccc gcgggtcgtc ggactcgcgc ccgacctcgt
    26581 ctcgttcgcg gcgggcggca acgacatcat ccggcccggc accgatcccg acgaggtcgc
    26641 cgagcggttc gagctggcgg tggccgcgct gaccgccgcg gccggaaccg tcctggtgac
    26701 caccgggttc gacacccggg gggtacccgt cctcaagcac ctgcgcggca a
//
