LOCUS       NZ_BMVQ01000009        21086 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces anthocyanicus strain JCM 4739 sequence09, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVQ01000009
VERSION     NZ_BMVQ01000009.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces anthocyanicus
  ORGANISM  Streptomyces anthocyanicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceoruber group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 388943)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:14:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,934
            CDSs (total)                      :: 7,858
            Genes (coding)                    :: 7,681
            CDSs (with protein)               :: 7,681
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 73 of 177
            Pseudo Genes (incomplete)         :: 130 of 177
            Pseudo Genes (internal stop)      :: 16 of 177
            Pseudo Genes (multiple problems)  :: 37 of 177
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:48:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 207152
            Orig. end                         :: 228238
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVQ01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11086)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(117..132)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.22"
                     /tool="antismash"
     gene            266..1030
                     /locus_tag="IE283_RS24235"
                     /old_locus_tag="GCM10010348_49030"
     CDS             266..1030
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="IE283_RS24235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49030"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_003973740.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEGGATVRTARVPKYYRLKKHLLDMTRTQTPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SQDRTGQPVEWVRSVYRGDRYKFVARLKRPQD"
     misc_feature    1080..1094
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(1100..1112)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            1165..1422
                     /locus_tag="IE283_RS24240"
                     /old_locus_tag="GCM10010348_49050"
     CDS             1165..1422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973741.1"
                     /locus_tag="IE283_RS24240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49050"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_003973741.1"
                     /transl_table=11
                     /translation="MPEDTEVSREPVVTPVRVVIGFCLVAPFVAMLWVGSYAKTDPAFI
                     GIPFFYWYQMAWVLISTLLTVTAYKLWQRDQRGRREGGTK"
     gene            1419..3029
                     /locus_tag="IE283_RS24245"
                     /old_locus_tag="GCM10010348_49060"
     CDS             1419..3029
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444565.1"
                     /locus_tag="IE283_RS24245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49060"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_003973742.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFIFFFVLVTAMGFLAARWRRAENEHSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     EDTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDDIFASASDKFTAAGKGGVVPDAGGQWTYATLALGSALALFMYPHSITATLSSRSREV
                     IRRNTTILPLYSLMLGLLALLGFMAIAAGVKVDNGQLAIPQLFENMFPDWFAGVAFAAI
                     GIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPQQETKVSKLVSLLVKVGALIFVLGM
                     DKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLGGWAVGMVYGTVAAYGVASPT
                     QKHFGGSSDEIPGIGEIGYIGLTAFVLNVLVTVVLTFVLRAVKAPDGVDETRPSDYTAD
                     AGDPGVQVELPPATAGSSH"
     gene            3102..3608
                     /locus_tag="IE283_RS24250"
                     /old_locus_tag="GCM10010348_49070"
     CDS             3102..3608
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="IE283_RS24250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49070"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_003973743.1"
                     /transl_table=11
                     /translation="MDFVIRRATAEEYDTLGEITAQAYLRDGLLDFGESDSYLDELRDV
                     AKRAAAAEVLVAVADGAVLGGVTFVPSGGPMADIARPGEAEIRMLAVAREARGRGAGEA
                     LVRACADRARAVPGCTGVVLSTQAAMRTAHRLYERLGFVRTPDRDWNPLPELDDIMLLT
                     YELTL"
     misc_feature    3645..3659
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     misc_feature    3676..3690
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    3684..3697
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     regulatory      3712..3809
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            3959..6334
                     /locus_tag="IE283_RS24255"
                     /old_locus_tag="GCM10010348_49080"
     CDS             3959..6334
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444560.1"
                     /locus_tag="IE283_RS24255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49080"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_193486335.1"
                     /transl_table=11
                     /translation="MTIAPADPASATPVTATGESDGPGAALLRTLTGLTADLPGADPGR
                     VAAAALRGRSARADEAELRELATEAAAGLISEDPVYSRLAARLLTMGIRAEAASQGVVT
                     FTDSVATGHREGLIADRTAAFVRLHADRLDALIDQDADDRFGYFGLRTLYSRYLLRHPI
                     TRKAVETPQHFLLRVAAGLAEDDTVRAADEVAALYGLMSRLDYLPSSPTLFNSGTRHAQ
                     MSSCYLLDSPKDELDSLYDRLHQVARLSKHAGGIGIAYSRVRARGSLIRGTNGHSNGIV
                     PFLKTLDASVAAVNQGGRRKGAAAVYLETWHADVEEFLELRDNTGEDARRTHNLNLAHW
                     IPDEFMRRVDADGTWSLFSPADVPELTDLWGEEFDAAYRRAEEAGLARRTLPARELYGR
                     MMRTLAQTGNGWMTFKDTANRTANQTATPGHVVHSSNLCTEILEVTDDGETAVCNLGSV
                     NLGAFVDPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMG
                     LQDVFFRLRLPFDSPEAKVLSTRIAERIMLAAYETSADLAERNGPLPAWEKTRTARGVL
                     HPDHYGVEPAWPERWAALRARMATTGLRNSLLLAIAPTATIASIAGVYECIEPQVSNLF
                     KRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFTWIPEDVRALYRTAW
                     EIPQRGLIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPA
                     TRIARAAARATTVPVQAAPDPEAVACSLENPESCEACQ"
     gene            6334..7365
                     /locus_tag="IE283_RS24260"
                     /old_locus_tag="GCM10010348_49090"
     CDS             6334..7365
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973746.1"
                     /locus_tag="IE283_RS24260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49090"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_003973746.1"
                     /transl_table=11
                     /translation="MTTETPVHPTTKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWHV
                     EEVDLHSDVADLAKLSPMEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLS
                     RQLFEEAVHVQFYLTLLDTYLPDPEDRAAAFAAVENIPSIREKAEFCFRWMDSVESIDR
                     LETKADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMH
                     MSFAFDVVDTVRKEEPELFDDQLREQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMR
                     QYLECVADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLS
                     EDF"
     gene            complement(7278..7544)
                     /locus_tag="IE283_RS24265"
                     /old_locus_tag="GCM10010348_49100"
     CDS             complement(7278..7544)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047586.1"
                     /locus_tag="IE283_RS24265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49100"
                     /product="hypothetical protein"
                     /protein_id="WP_003973747.1"
                     /transl_table=11
                     /translation="MTGNQIEALVGMLATFGLLVLMILPSVIGIVRDRRIDRRIREARE
                     DGETRTRYGKETRSTQKSSDRSTVPSTATWYAEGRRSKKLVNS"
     gene            7637..8605
                     /locus_tag="IE283_RS24270"
                     /old_locus_tag="GCM10010348_49110"
     CDS             7637..8605
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030121.1"
                     /locus_tag="IE283_RS24270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49110"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_193486338.1"
                     /transl_table=11
                     /translation="MLRNVAAVLLDGAHPFELGVVCEVFGIDRSDEGLPVYDFAVVSAE
                     GPTLGTHVGGLTVSTPYGLERLEEADLIAVPAGSDFVRREYPPDLLDALRRATDRGTRV
                     LSVCSGVFVLGAAGLLDGRRCAVHWHHAAELARQHPRARVAPDVLYVDEDPVITSAGTA
                     AGIDACLHIVRKEQGQEVANRIARRMVVPPHRDGGQAQYIERPLPHSSCDTVGEVLAWM
                     EQHLDEEVTVEQLAVRAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETM
                     DTIAWRAGFGTAAALRHQFTRALGTTPHAYRRTFRGPEAAA"
     gene            complement(8619..10004)
                     /locus_tag="IE283_RS24275"
                     /old_locus_tag="GCM10010348_49120"
     CDS             complement(8619..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326965.1"
                     /locus_tag="IE283_RS24275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49120"
                     /product="cytochrome P450"
                     /protein_id="WP_011030120.1"
                     /sec_met_domain="p450 (E-value: 1.2e-71, bitscore: 236.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPL
                     AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGV
                     ATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAV
                     RVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD
                     LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS
                     TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV
                     LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA
                     MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRP
                     VAR"
     gene            complement(10001..11086)
                     /gene="cyc1"
                     /locus_tag="IE283_RS24280"
                     /old_locus_tag="GCM10010348_49130"
     CDS             complement(10001..11086)
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="IE283_RS24280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49130"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_193486400.1"
                     /sec_met_domain="T1TS (E-value: 3.7e-63, bitscore: 208.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFPHGTTATPTAIAVPPSLRLPVIEAAFPRQLHPYWPKLQETT
                     RTWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGAPDEVLQAIADYSAWFFVWDDRHDR
                     DIVHGRAGAWRRLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFAR
                     HFHTVIEAYDREFHNRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKH
                     PAYCRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVRRRVE
                     ECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFSSVYWFHHESGRYM
                     VDSWDDRSTPPYVNNEAAGEK"
     misc_feature    complement(10202..10204)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11345..11995)
                     /gene="def"
                     /locus_tag="IE283_RS24285"
                     /old_locus_tag="GCM10010348_49140"
     CDS             complement(11345..11995)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="IE283_RS24285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49140"
                     /product="peptide deformylase"
                     /protein_id="WP_193486340.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHPGVLPVDDEGFVVDSQDCEEREADWRGRGTSRPIT
                     VVGNPVLHKECEDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIGVSKKVFVYDCPDD
                     EGVRHVGVVCNPRLVELPADRRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDERGNPV
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND"
     gene            complement(12075..13055)
                     /locus_tag="IE283_RS24290"
                     /old_locus_tag="GCM10010348_49150"
     CDS             complement(12075..13055)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="IE283_RS24290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49150"
                     /product="hypothetical protein"
                     /protein_id="WP_003973752.1"
                     /transl_table=11
                     /translation="MRIFGKARHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRDIGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRTPGGATDAGEPLGMDLGSAAVRLSPEGEAEVVWGRRLDPARVEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSAGHSYPVFDEIELWAPSPVPTWVVLLEAATESDRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPAGLVKGLLDGWVADSPDSRDWRDLEEVC"
     gene            complement(13170..14435)
                     /locus_tag="IE283_RS24295"
                     /old_locus_tag="GCM10010348_49160"
     CDS             complement(13170..14435)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973753.1"
                     /locus_tag="IE283_RS24295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49160"
                     /product="metal-dependent phosphohydrolase"
                     /protein_id="WP_162495247.1"
                     /transl_table=11
                     /translation="MTPLQPPARSSPPAAVLLVPGCAGLLALGCLASVLGAGPAQRPVA
                     LAFGGLVVLGELTRRTGAEAREAAPLGAAGALAYALLGDVAGQPAHHGVAETVTVVLAA
                     SLLGSVPYVARGSGPVLDHLARRVLTVGFAAVCFRPLSNQGVFDDWSGPAYALLLLGLL
                     ALTTLCDAVLAAAPAHARTGWPFGPLLREELRGMVGITSAVCATGAVMALAVSVAGLWA
                     LPVFSVPLLLAQLSYRRYAAVRATYRQTIASLARATEIAGYTPAGHARRVAGLGVAVGR
                     DLGLSGAELTVLEYAALMHDIGQLSLVDPVPAGATAGLPVTEQRRIALLGGAVVRQTGV
                     DAAVAVVVERQADPCREQPVAARIVRVVNAYDEKARDAGPGGVLTALEELRLATAGDYA
                     PEVVEALARVLSRGSLTEPAAG"
     gene            complement(14432..15757)
                     /locus_tag="IE283_RS24300"
                     /old_locus_tag="GCM10010348_49170"
     CDS             complement(14432..15757)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973754.1"
                     /locus_tag="IE283_RS24300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49170"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_093456974.1"
                     /transl_table=11
                     /translation="MDAVPARARVYVAVVALTALLCLRPLPAVHAPWWAVLLLAGLYAG
                     SELVARSRFVGTCYPVLLAGAFLLPPPAAALVALPGALLAPVPRRPLGLRRVWRAAQLT
                     LAVWAAACVHWRLGGRDAVVEPAFPYALVPAGAAVLAFCLVLTVLDGGILTLADHVPPS
                     RAWRGLLSRSLAPIAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVAWWAFAQYHRERA
                     AHQATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMDDERVETLRFAGILHDVGK
                     LGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIRFLGEARAAVLHHHERLDGSGYP
                     YGLAGDRIPESARVVAVADAFDAMTSTRSYSRARPVATALAELQRCAGGQFDPRMVRAL
                     VRALGRHGWRPSVTADSPLTRTAGPAPDRGEDARDSVGRGAP"
     gene            complement(15886..16203)
                     /gene="rsrA"
                     /locus_tag="IE283_RS24305"
                     /old_locus_tag="GCM10010348_49180"
     CDS             complement(15886..16203)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326971.1"
                     /locus_tag="IE283_RS24305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49180"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_003973755.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPGDLRAKVMGRLDLIRSGQSVPEHDVAAAPSSSAPQE
                     S"
     gene            complement(16200..16883)
                     /gene="sigR"
                     /locus_tag="IE283_RS24310"
                     /old_locus_tag="GCM10010348_49190"
     CDS             complement(16200..16883)
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="IE283_RS24310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49190"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_003973756.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTEHGQAEQPEGRGTGAESTAERSARFERDALEFLD
                     QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK
                     QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKQALQAIPEEFRIAV
                     YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEA
                     KGSGS"
     misc_feature    complement(16846..16861)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     misc_feature    16939..16953
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     gene            complement(17141..17776)
                     /locus_tag="IE283_RS24315"
                     /old_locus_tag="GCM10010348_49200"
     CDS             complement(17141..17776)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973757.1"
                     /locus_tag="IE283_RS24315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49200"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_093456973.1"
                     /transl_table=11
                     /translation="MTEAVETDAGPARITWHRAKQPRLVLAVSHGAGGGIEARDLKALA
                     AALPAHGVSVALVEQPWRVAGRKLAPAPKTLDTGWRGVWPALAAPGLPVISGGRSAGAR
                     VACRTAGELGARAVLALSFPLHPPGRPEKSRADELLGAGVPTLVVQGGNDPFGRPQEFP
                     EAPGGTYELIEVPYGDHGFAVPKRAEISQERALELITDGVAQWAGSLG"
     gene            complement(17799..18614)
                     /locus_tag="IE283_RS24320"
                     /old_locus_tag="GCM10010348_49210"
     CDS             complement(17799..18614)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="IE283_RS24320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49210"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_011030116.1"
                     /transl_table=11
                     /translation="MCGRYAASRRPEDLAGIFEIEKWEPKESLEPDYNVAPTKEVYAVL
                     DRPLKDVEDPEPVRQLRKLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFSTRR
                     CILPADGYYEWVTGKQERDLEVEGRKKRPRKQPYFVTPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAETTPLAVAPADGPHALADIHPRMPLMLTPDRWDDWLDPART
                     DPDELTSLLAPPPTGLMRAFPVSTAVSNVRNNGPELLEELEAPEEGTLF"
     gene            18665..19387
                     /locus_tag="IE283_RS24325"
                     /old_locus_tag="GCM10010348_49220"
     CDS             18665..19387
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973759.1"
                     /locus_tag="IE283_RS24325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49220"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_003973759.1"
                     /transl_table=11
                     /translation="MDHLATASLTSLWDEVSGIQPDPDLWVVVATLVAALAVVATRGSW
                     RIARNAITIAHEGGHGLVALLTGRTLTGITLHSDTSGLTVSRGKPHGVGMILTAVAGYT
                     APPLLGLGGAALLAAGRITLLLWLATALLVALLVMVRNAYGVLTVVVTGGTFVLVSWLA
                     GPQVQAAFAYAVVWFLLLGGVRPAFELQAKRSRGGAGDSDADQLARLTHAPAGVWFFLF
                     HAVSLCSLIGGARWLLEL"
     gene            19511..20827
                     /gene="aroA"
                     /locus_tag="IE283_RS24330"
                     /old_locus_tag="GCM10010348_49230"
     CDS             19511..20827
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824681.1"
                     /locus_tag="IE283_RS24330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_49230"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_093456972.1"
                     /transl_table=11
                     /translation="MTVNPTHTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAEALRMMGVEIEEGVGPEGTGEFWRVIPAGLRGPATVDVGNAG
                     TVMRFLPPVATLADGAVRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGG
                     GALEGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHTGSALPSMPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKVVIPDWPSRT
                     TQPGDRLREIFTDMGGSCELTDFGLVFTGSGAIHGIDVDLSEVGELTPGIAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYDDHRM
                     ATAGAVLGLAVEGVQIENVATTAKTLPDFPDLWTGMLGA"
ORIGIN
        1 ggacctttca ttgcgcaagc gacagttcgg gcggaccggg accgggtgta ccacccccca
       61 tcgaatgacg tgcggggacg cccccgaacg cgcgtaccag cggcgtccga cccacctatg
      121 gactagacca agggtgttcc cccgggtata cagaagggat cacggagcgt gcgggggcca
      181 tcccggcacg aagccgtgcc acgatgtgag ccgtggccga cagggatagc ggtcgcttcg
      241 gcacccggag ccgggaaggc agagcatgag caccgacgtc agcagtgcgg agaacgaggg
      301 tggggcgacc gtccgtaccg cgcgcgtgcc caagtactac cgtctgaaga agcatctgct
      361 cgacatgacc cggacccaga cgccgggcac accggtcccg ccggagcgca ccctggccgc
      421 cgagttcgac acctcgcgca cgacggtgcg ccaggccctg caggagctgg tggtcgaggg
      481 ccgcctggag cgcatccagg gcaagggcac cttcgtcgcc aagcccaagg tgtcgcaggc
      541 gttgcaactc acctcgtaca ccgaggacat gcgggcccag ggcctcgaac cgacctctca
      601 gctgctggac atcggctaca tcaccgccga cgaccggctc gccgggctgc tggacatcac
      661 ggccggcggc cgggtgctgc gcatcgagcg gctgcgcatg gccaacggcg agccgatggc
      721 catcgagacc acccacctca gcgcgaagcg cttccccgcc ctgcgccgct ccctggtgaa
      781 gtacacgtcc ctctacaccg cgctcgccga ggtgtacgac gtccatctcg ccgaggccga
      841 ggagaccatc gagacctccc tggccacccc gcgcgaggcc ggtctgctcg gcaccgacgt
      901 cggcctgccc atgctgatgc tctcccggca ctcccaggac cgcaccggcc agccggtgga
      961 gtgggtccgc tcggtgtacc ggggcgaccg ctacaagttc gtggcccgcc tcaagcggcc
     1021 ccaggactag accagagccc gctcacccgg ccccagattg cggttgagga ccgatatacg
     1081 gacgaggtct tccgctgtct tgacaccgtc acctacattt cgtgcgcact gcacgaggtg
     1141 atcagcgagg ggacggagcc gcgcatgcca gaagacacag aagtgagcag agaaccggtg
     1201 gtgacgccgg tgcgcgtcgt catcgggttc tgtcttgtcg caccgttcgt cgccatgctg
     1261 tgggtcggtt cgtacgccaa gacggacccg gccttcatcg gcatcccgtt cttctactgg
     1321 taccagatgg cctgggtgct gatctccacc ctgctgacgg tgaccgcgta caagctgtgg
     1381 cagcgcgacc agcgcgggcg ccgggaaggc gggaccaagt gaacgacggc gtgaacggcg
     1441 tcgcactcgc cgtcttcatc ttcttcttcg tcctcgtcac cgccatgggc ttcctggccg
     1501 cccgctggcg ccgggccgag aacgagcaca gcctcgacga gtggggcctc ggcggccgct
     1561 cgttcggcac ctgggtcacc tggttcctgc tgggcggcga cctgtacacc gcgtacacct
     1621 tcgtggccgt cccggcggcg atctacgcgg cgggcgcgtc cggcttcttc gcggtgccgt
     1681 acacgatcct ggtctacccg ctgatcttca ccttcctgcc ccgcctgtgg tcggtctcgc
     1741 acaagcacgg gtacgtgacg acctcggact tcgtgcgcgg ccggttcggc tccaagggcc
     1801 tgtcgctggc ggtggccgtc accggcatcc tggcgaccat gccgtacatc gcgctccagc
     1861 tggtcggcat ccaggccgtc ctcgacgtga tgggcgtcgg cggcggcgag gacaccaact
     1921 ggttcgtcaa ggacctgccg ctgctgatcg ccttcggtgt gctggcggcg tacacgtact
     1981 cgtcgggact gcgcgcgccc gcgctgatcg cgttcgtgaa ggacacgctg atctacatcg
     2041 tcatcgcggt ggcgatcatc tacatcccga tcaagctggg cggcttcgac gacatcttcg
     2101 cgtcggcgag cgacaagttc accgcggcgg gcaagggtgg cgtggtgccc gacgcggggg
     2161 gccagtggac ctacgcgacc ctggcgctcg gctcggccct ggcgctcttc atgtacccgc
     2221 actcgatcac cgccacgctg tcctcgcgca gccgtgaggt gatccgccgc aacaccacga
     2281 tcctgccgct gtactcgctg atgctgggcc tgctcgcgct gctcggcttc atggcgatcg
     2341 cggccggggt caaggtggac aacggccagc tggcgatccc gcagctgttc gagaacatgt
     2401 tcccggactg gttcgcgggc gtggcgttcg cggcgatcgg catcggcgcc ctggtcccgg
     2461 cggcgatcat gtcgatcgcg gccgcgaacc tcttcacccg caacatctac aaggacttca
     2521 tcaagccgga cgccacgccg cagcaggaga ccaaggtctc caagctggtg tcgctcctgg
     2581 tgaaggtggg cgcgctgatc ttcgtcctgg gcatggacaa gaccgtcgcg atcaacttcc
     2641 agctgctggg cggcatctgg atcctgcaga ccttcccggc cctggtcggc ggcctgttca
     2701 cccgctggtt ccaccgctgg gcgctgctcg gcggctgggc ggtcggcatg gtctacggca
     2761 cggtcgccgc ctacggtgtc gcctcgccga cgcagaagca cttcggcggc tcctccgacg
     2821 agatccccgg catcggcgag atcggctaca tcggcctcac cgccttcgtg ctgaacgtgc
     2881 tggtcaccgt ggtcctgacc ttcgtcctga gggcggtcaa ggcgcccgac ggcgtcgacg
     2941 agaccaggcc gagcgactac acggcggacg ccggcgaccc gggcgtccag gtggaactgc
     3001 cgccggccac ggcgggcagc tcgcactgat ccctggttcg aggcgggccg ccggagaaat
     3061 ccggcggccc gttgtcgtac ccgtcgggca cactctgcgt catggacttc gtgatccggc
     3121 gggcgacggc cgaggagtac gacaccctcg gcgagatcac cgcgcaggcc tacctgcgcg
     3181 acggcctcct cgacttcggg gagagcgact cgtacctgga cgagctgcgc gacgtggcca
     3241 agcgggcggc ggccgccgag gtgctggtcg ccgtggccga cggcgcggtg ctcggcggcg
     3301 tgaccttcgt gccgtccggc ggccccatgg cggacatagc gcgccccggc gaggccgaga
     3361 tacgcatgct cgccgtcgcc cgggaggcac gcggccgcgg ggcgggcgag gccctcgtgc
     3421 gggcctgcgc cgaccgcgcc cgggccgtgc cggggtgcac gggcgtcgtg ctgtcgacgc
     3481 aggccgccat gcgcaccgcg caccgcctct acgagcgcct gggcttcgtc cgcacgcccg
     3541 accgcgactg gaatcccctg ccggagctgg acgacatcat gctgctcacc tacgaactga
     3601 cgctctgaca cggccgcggc acaccgtcac gacaccgcgc cgggacacaa catctggggg
     3661 tgctcgcgtc ccccggcaca agatgtatgc tcatgctcgc tgtcgccgca ggggaatccg
     3721 gtgcgaatcc ggaactgtcc cgcaacggtg tacttgcgtg catccgtacg tcttcgcacg
     3781 tgcgcgcacg cctgtccagt ccgaggacct gccgacagtg cgcccggccg ccctggcccg
     3841 ggtgccatga cgtccgggcc tcgcggagtg ggccggtgga cgcgacgccg cgtgcgctcg
     3901 tgagctgccc cctgccctcc ctccgccggg ccccgtgccg agcgagggag tgctccacgt
     3961 gaccatcgcg ccagccgatc cggcttcagc gaccccggtg acggcgaccg gggaatccga
     4021 cggacccggt gccgccctgc tgcggaccct gaccgggctg accgccgacc tccccggcgc
     4081 cgaccccggc cgggtggccg ccgccgcact gcgcggccgg tccgcccgcg ccgacgaggc
     4141 cgagctgcgc gagctggcca ccgaggcggc cgccggtctg atctccgagg acccggtcta
     4201 ctcccggctg gccgcccgcc tgctgaccat gggcatccgc gccgaggccg cctcccaggg
     4261 cgtcgtcacc ttcaccgact ccgtcgccac cggccaccgc gagggcctga tcgccgaccg
     4321 caccgccgcc ttcgtacggc tgcacgcgga ccgcctggac gcgctgatcg accaggacgc
     4381 cgacgaccgc ttcggctact tcggcctgcg tacgctctac agccgctacc tgctccgcca
     4441 cccgatcacc cgcaaggcgg tcgagacgcc ccagcacttc ctgctgcggg tcgccgccgg
     4501 actcgccgag gacgacacgg tgcgcgcggc ggacgaggtc gccgcgctgt acggcctgat
     4561 gagccgcctg gactacctgc cctcctcccc caccctcttc aactccggca cccggcacgc
     4621 ccagatgtcg tcctgctacc tcctggactc ccccaaggac gagctggact ccctctacga
     4681 ccgcctccac caggtggccc gcctgtccaa gcacgccggc ggcatcggca tcgcctactc
     4741 ccgcgtccgc gcccggggtt cgctgatccg cggcaccaac gggcactcca acggcatcgt
     4801 cccgttcctg aagacgctgg acgcctcggt ggcggccgtg aaccagggcg gccggcgcaa
     4861 gggcgcggcc gcggtctacc tggagacctg gcacgcggac gtcgaggagt tcctggagct
     4921 gcgggacaac accggcgagg acgcccgccg cacgcacaac ctgaacctcg cgcactggat
     4981 cccggacgag ttcatgcgcc gggtggacgc cgacgggacc tggtcgctgt tctcccccgc
     5041 cgacgtgccg gagctgaccg acctgtgggg cgaggagttc gacgccgcct accgcagggc
     5101 ggaggaggcg gggctcgccc gcaggacgct gcccgcccgt gagctgtacg gccgcatgat
     5161 gcgcaccctc gcgcagaccg gcaacggctg gatgaccttc aaggacaccg ccaaccgcac
     5221 ggccaaccag accgcgaccc ccggccacgt cgtccactcc tccaacctct gcacggagat
     5281 cctggaggtc accgacgacg gggagaccgc ggtctgcaac ctgggctcgg tcaatctcgg
     5341 cgcgttcgtc gacccggcgc acggggacat ggactgggag cgcctggacg ccaccgtccg
     5401 caccgcggtc accttcctgg accgggtcgt cgacatcaac ttctacccga ccgagcaggc
     5461 gggccgctcc aacgcccgct ggcgcccggt cggcctcggc gcgatgggcc tccaggacgt
     5521 cttcttccgg ctgcgcctgc ccttcgactc ccccgaggcg aaggtcctgt ccacccgtat
     5581 cgccgagcgg atcatgctcg ccgcgtacga gacctccgcc gacctcgccg agcgcaacgg
     5641 cccgctgccg gcctgggaga agacccgtac ggcccggggt gtgctgcacc ctgaccacta
     5701 cggcgtcgag cccgcctggc cggagcgctg ggccgcgctg cgcgcgcgca tggcgacgac
     5761 cgggctgcgc aactccctgc tcctggccat cgccccgacc gcgaccatcg cctccatcgc
     5821 cggtgtctac gagtgcatcg agccgcaggt ctccaacctg ttcaagcgcg agacgctgtc
     5881 cggcgagttc ctccaggtca actcgtacct ggtggacgac ctcaagcggc tcggcgtgtg
     5941 ggacgcgcgc acccgtgagg cgctgcgcga ggccaacggc tcggtgcagg gcttcacctg
     6001 gattcccgag gacgtgcgcg cgctgtaccg caccgcctgg gagatcccgc agcgcggcct
     6061 gatcgacatg gccgccgccc gcaccccgta cctcgaccag gcccagtcgc tgaacctgtt
     6121 cctggagacg ccgaccatcg ggaagctctc ctcgatgtac gcgtacgcct ggaagcaggg
     6181 cctgaagacc acgtactacc tgcgctcgcg tccggcgacc cggatcgccc gggccgcggc
     6241 ccgcgccacc accgtccccg tgcaggccgc cccggacccc gaggcggtcg cctgctccct
     6301 ggaaaacccc gagtcctgcg aggcctgcca gtaatgacca ccgagacccc cgtgcacccc
     6361 accaccaaga acctgctcga cccgggcttc gagctgaccc tgcgccccat gcgctacccg
     6421 gacttctacg agcgctaccg ggacgccatc aagaacacct ggcacgtcga ggaggtcgac
     6481 ctccactcgg acgtcgccga cctcgcgaag ctcagcccga tggagcagca cctgatcggc
     6541 cggctcgtgg ccttcttcgc caccggcgac tcgatcgtcg cgaacaacct ggtgctgacc
     6601 ctctacaagc acatcaactc ccccgaggcg cggctgtacc tgtcccgcca gctcttcgag
     6661 gaggccgtcc acgtccagtt ctatctgacg ctcctcgaca cctacctgcc cgacccggag
     6721 gaccgcgccg ccgccttcgc ggccgtggag aacatcccgt ccatccggga gaaggccgag
     6781 ttctgcttca ggtggatgga ctcggtcgag tcgatcgacc ggctggagac caaggccgac
     6841 cggcgccgct tcctgctcaa cctgatctgc ttcgcggcgt gcatcgaggg cctgttcttc
     6901 tacggcgcct tcgcctacgt ctactggttc cgcagccggg gtctgctgca cggcctggcc
     6961 accggcacca actgggtgtt ccgggacgag acgatgcaca tgtccttcgc cttcgacgtc
     7021 gtcgacaccg tgcgcaagga ggagccggag ctgttcgacg accagctccg ggagcaggtc
     7081 accgacatgc tgagggaggc cgtcgaggcc gagctgcagt tcgcgcgcga cctgtgcggc
     7141 gacggcctcc cgggtatgaa caccgactcg atgcggcagt acctggagtg cgtggccgac
     7201 cagcgtctga cgcggctcgg cttcgccccg gtgtacggct ccgagaaccc cttctccttc
     7261 atggagttgc agggcgttca ggagttgacc aacttcttcg agcggcgccc ctcggcgtac
     7321 caggtggcgg tggagggcac ggtcgacctg tccgaggact tctgagtgct ccgggtctcc
     7381 ttcccgtagc gggtccgggt ctccccgtcc tcccgcgcct ccctgatccg gcggtcgatg
     7441 cgccggtcgc gcacgatgcc gatcaccgag gggaggatca tgaggacgag gagtccgaag
     7501 gtcgcgagca ttccgacaag ggcttcgatc tggtttccgg tcatgacacc actgtcgcgc
     7561 cggagactcc ttaccgggag tggcaggact gccgtaaggc ctcgatttcc tgccaccggc
     7621 gaggcacact ggcggcatgc tgcggaacgt ggcggccgtc ctgctggacg gtgcgcatcc
     7681 cttcgaactg ggcgtggtct gcgaggtctt cggcatcgac cggagcgacg agggcctgcc
     7741 ggtgtacgac ttcgcggtgg tctccgcgga gggccccacg ctgggcactc acgtcggcgg
     7801 gctgaccgtc tccacgccgt acggtctgga gcggctggag gaggccgacc tgatcgcggt
     7861 accggcgggc agcgacttcg tccgccggga gtacccgccc gacctgctgg acgccctgcg
     7921 cagggcgacg gaccggggca cccgcgtgct gagcgtgtgc tccggcgtct tcgtgctggg
     7981 cgccgccggc ctgctggacg ggcggcggtg cgcggtgcac tggcaccacg cggccgagct
     8041 ggcccgccag cacccgcggg cccgggtcgc gccggacgtg ctctacgtcg acgaggaccc
     8101 ggtgatcacc tcggccggga ccgccgccgg catcgacgcc tgcctgcaca tcgtgcgcaa
     8161 ggagcagggg caggaggtcg ccaaccggat cgcccggcgc atggtggtgc ctccgcaccg
     8221 ggacggcggg caggcgcagt acatcgaacg gccgctgccg cactcctcct gcgacaccgt
     8281 cggcgaggtg ctggcctgga tggagcagca cctcgacgag gaggtgacgg tcgagcagct
     8341 ggcggtccgg gcgcacatgt ccccgcgcac cttcgcccgc cgcttccagc aggagaccgg
     8401 gacgaccccc taccgctgga tcctgcgcca gcgcgtactg ctggcccagc ggctgctgga
     8461 agcgacggac gagaccatgg acacgatcgc ctggcgcgcc ggtttcggca cggcggcggc
     8521 cctgaggcac cagttcacca gggccctggg caccaccccg cacgcctacc ggcgcacctt
     8581 ccggggcccg gaggccgccg cctgacccgt ccgggtcgtc accgcgccac gggcctgacc
     8641 agcaggtcgt gcggacgcag cgtgatcccg acccggaccg cgtcgttcga gcccgccacc
     8701 tgttcgaagc ggtacttcgt ggcgagcgcg gccgtgatca gcgtgagctg ggccatcgag
     8761 aagtggtcac tggggcactt ccgcttgccc gcgctgaacg gcttcatggc gtatttcggc
     8821 acattcgccg cgcgttccgg tagccaccgg tcgggatcga actccaggtt gtcgtcgtac
     8881 gacttcggat cgcgttggat tgcgtacgga ctgtagatga tgtccgcacc ggccggaatg
     8941 cgatagccac cgagttcgct ctcggccacc gcgcgccggg tcaataccca tacggcggga
     9001 cgcaaacgca tggcctccac gatgacattg ccggtgtgcc tgagcttccg gacgtcctcg
     9061 aatgccacgg gacgtccgcc ggtgaccgct tcgacttcgt cgcgtatgcg gtcggcatgt
     9121 tccggatggt cggcaagtgc ctggagcaac cacatgatcg tggacgcgat ggtttcactg
     9181 cccggggtga gtatcgcgac cacctggtcg tggatctcct gttccccgat cgggtctcca
     9241 ttgtcgtcct tcgcctccag caatgccgtg agcaaatcgt ccggcttttg accggatgca
     9301 cggcgctcgg cgatgatctc gtcgaccagc aggtgcagat cggccaacgc gtcgttgaat
     9361 cggcggttgg ccggaagcgg cagccggtac agcggcccga gcgggaccac catccgccgg
     9421 tacatgcccc ggaagacggt ggcgagcgcg acgcagagcc gctcggcccg ctcgtccatg
     9481 tactgcccgc gcagcaggca gcgggccgcg acgcgcacgg cgacccggaa ggactccgag
     9541 gtggcgtcga cggtcttccc cggctgccag cgctcggtga gcgcgtgcgc ctcctcctcc
     9601 atgatcggcc cgtaggcggg gatggcgtcg agccggaacg ccggctggat ggtgcgccgc
     9661 tggcggcggt ggagcgggcc gttggcggtc gccacgccct ccttgccgag caggccctcc
     9721 agcgactccc acagcggacc ggcgatgtgg tagtcggggt tcagggcgag ggcgccggtc
     9781 agctcggggt tcgtgacggc gtagacggtc ttcgggccga gcttgatgcg cacgacgtcg
     9841 ccgtggtcgc gcagctggga catgaaggcc agcgggtcgc gggccagccg ccagccgtgg
     9901 ccgagcagcg gaacgccacc gcccgcgacg ggcggctcgc gcagctccgg tgctcccggt
     9961 gccgcgggtg cgcgggtttc ggggttgacg gactcgacgg tcatttctca cctgccgctt
    10021 cgttgttgac gtacgggggc gtggaccggt cgtcccagct gtcgaccatg taccggccgg
    10081 actcgtggtg gaaccagtag acggaactga accagttccg catattgccg acgttggccc
    10141 gcacggcgcc gctcagttcc tttccgcgta cggttccgtc ggcgagttcg tcggcgaacc
    10201 gtaaggcgtc ccgctcgacg gcgagaaatt ccgtgatgca ttcctcgaca cgacgccgga
    10261 cttctccgat ggcttcttcc agggtgagtg aatggtgggt gatgagactg atgccaagat
    10321 tgtggacctc gtctcccgct atttcctttg gcagtgagca gaggtcgttg taccaggcgg
    10381 cgaattcctg actcagcaac gccgcccggc aatatgccgg gtgtttccgt acggcgtcgg
    10441 ggagttcgca gcccgaactc ggctccagca ggtcggtcca gatccagtgc gcgaacgtga
    10501 gccggcgcag ttcgaggtac tcctccacgc cgggcacgat tccgcgcgtg cggttgtgga
    10561 attcacggtc gtacgcctcg atcaccgtgt ggaagtgccg ggcgaaccgg gcgttccagg
    10621 tggccggcag gaaggcgtag agccgccgca cactgtcggc gaacccggcc accagcgtgt
    10681 cctcgtggtg caggtggtcc ccgggtgagt ccagtgccgt gtgcagcagg ccgcgcagtc
    10741 gccgccaggc accggcccgg ccgtggacga tgtcacggtc gtgacggtcg tcccagacga
    10801 agaaccacgc gctgtagtcc gctatcgcct gcaggacctc gtcgggggcg cccaggtagt
    10861 agcccgccat gaggtccgtg tagcacagac cgtcggcata ttcctcgacc ttgtccgccg
    10921 gcatgagccg cttttcgagc agccaggtcc gggttgtctc ctggagcttc ggccaatacg
    10981 ggtgcagttg ccggggaaat gccgcctcga tcaccgggag acggagcgat ggcggtactg
    11041 cgatcgcggt cggtgtcgct gtggtgccgt gtgggaaagc atgcacgaac aaacccctct
    11101 cagccgccgg tggcgcaccc ctctcgctga gcggggcgtg cgccgttgcg tatccccgca
    11161 cttcccattc agcaccacaa ctgaccgttc tgggaacgga tttgcttcat tcactacccc
    11221 tggtgccgga attctcctgt tgtgtggcgg ctttccatgc gcgtgcacag acgaacggcg
    11281 cccgctcggg gaagacccga acaggcgccg tgcgcaaggg agatgtgggg cgggtgaggc
    11341 ggtgtcagtc gttcgcgacc acggggtagc gcggctcgtt ctcggccatc tgccgcagcg
    11401 cgtccttgcg ttcgcgcttg gagagccggt cgatgtacag gtacccgtac aggtggtccg
    11461 tctcgtgctg caaacaccgg gcgaagtacc ccgtgccgcg caccttgacc gggttgcccc
    11521 tctcgtcctg cccggtcacc tcggcgtagt cggggcgggc gagcggcgcg taggcggtgg
    11581 gcacggacag gcagccctcg ttgctgtcgt ccaggcggcg gcggtcggcc ggcagctcga
    11641 cgagcctcgg gttgcagacc acgccgacgt ggcggacgcc ctcgtcgtcg gggcagtcgt
    11701 agacgaagac cttcttggag acgccgatct ggttggcggc caggcccact ccctcggcgg
    11761 tgcgctggct ggcgaacatg tcggccacca gctgctggaa ctcctcgccg aagtcggtga
    11821 cgtcctcgca ctccttgtgc agcaccgggt tgccgaccac cgtgatcgga cgggaggtgc
    11881 cgcgcccgcg ccagtcggcc tcacgctcct cgcagtcctg gctgtcgacg acgaatccct
    11941 cgtcgtccac ggggagcacg cccgggtgct gctgatcggt gtcctgctgg gccatgaccg
    12001 acgtatgcct tcctcgtaca accaaaggtg atgctgacgc tgctgaagtg tcctgacaaa
    12061 gactacgggg ctgctcagca gacctcttcc aggtcccgcc agtcacggga gtccggactg
    12121 tccgcgaccc acccgtccag caaccccttc accagcccgg ccggcgcggc caccccgcac
    12181 tcccgctccg gcacccacag ctgcccgtcg gtgcggtgcc ccaggggccc ggggtgtccg
    12241 ggttcgctgt ggtcgtgcgg atcgaggtgc tcgccgtcgc cctcgtcgga cggcatccgg
    12301 gactccgagc acatccggca cagcagccgg acggaggacg accagtcctc ggcggcgaac
    12361 ccggcgtcgg cggccagctg ctccagggcg tcacggtcgg actcggtggc ggcctccagg
    12421 aggaccaccc aggtgggcac cggcgagggc gcccacagct cgatctcgtc gaagacgggg
    12481 taggagtgcc cggccgaggt cgtgcgctcc ccgtgcggta cgccgtcgtg caggacgacc
    12541 tcgccccagc gccggccgga ggacggcagc gggatggaca gcacctcgac gcgggcgggg
    12601 tccagccgcc gcccccacac cacctcggcc tcgccctccg gggacagccg tacggcggcg
    12661 ctgccgaggt ccatgccgag cggctcaccc gcgtccgtgg cgcccccggg ggtgcgcagc
    12721 ccgtaggcct gccaggcgcg acgggccagc ggccagtcct gaagggcggt cgcggcgatg
    12781 ccgacgttcc accagtcggg ggcgccgatg tcccggtcga gcagcgcgac ggcccgcaga
    12841 ccggccgccc tcgcctgttc ccagtcgtgc cggaacttgt gcagcagcgc caggttgaac
    12901 caggactccg acagccaggg ctccaggtcg gccgcccgcg tcagcagcgc gcccgcgtcc
    12961 tcgtagcgac cgtcgccgat cagcgtgaac gcgcggtcgg tggcctgccg ccaagaggcg
    13021 gagggccggt gccgtgcctt gccgaagatc ctcacgattc ccgcctgcca gttccgttct
    13081 gtgggctggc tgtgcctttt cgcgcccccg gacaccctct cccgggcatc aaaccacgta
    13141 cggctgcgga ggcgctcatt acccatgggt tacccagccg cgggctcggt aaggctgcct
    13201 cgggaaagga cccgggccag cgcttccacc acttccggag cgtagtcgcc cgcggtggcc
    13261 aggcgcagct cctccagcgc ggtcaggacg ccgccgggac ccgcgtcccg cgccttctcg
    13321 tcgtaggcgt tcacgacgcg tacgatccgc gcggcgaccg gctgctcccg gcaggggtcg
    13381 gcctgccgct ccaccaccac cgcgaccgcc gcgtcgacgc cggtctggcg gacgacggcc
    13441 ccgccgagca gcgcgatccg ccgctgttcg gtgaccggca ggccggccgt ggcacccgcc
    13501 gggaccgggt cgaccaggct cagctggccg atgtcgtgca tgagggccgc gtactccagc
    13561 acggtcagct cggcccccga cagccccagg tcccggccga cggccacccc gagcccggcg
    13621 acgcggcgcg cgtgcccggc cggggtgtat ccggcgatct cggtggcgcg ggccagggag
    13681 gcgatggtct gccggtaggt ggcccggacg gccgcgtacc gccggtagga gagctgggcg
    13741 agcagcaggg gcacggagaa gacggggagc gcccacagtc ccgcgacgct caccgcgagc
    13801 gccatcaccg cgccggtcgc gcacaccgcc gacgtgatcc cgaccatgcc gcgcagctct
    13861 tcgcgcagca ggggcccgaa gggccagccg gtgcgcgcgt gcgcgggtgc cgcggcgagc
    13921 accgcgtcgc acagcgtggt cagggcgagc agcccgagca gcagcagcgc gtaggcgggg
    13981 ccgctccagt cgtcgaagac gccctggttg gacagcggcc ggaagcacac ggcggcgaaa
    14041 ccgacggtga gcacgcgccg cgccaggtgg tcgaggacgg gcccgctgcc gcgcgcgacg
    14101 tagggcacgc tgccgagcag cgaggcggcg agcacgacgg tgacggtctc ggccacaccg
    14161 tggtgcgcgg gctgcccggc gacgtctccg agcagcgcgt acgccagcgc gcccgcggcc
    14221 ccgagcggag ccgcctcccg ggcctcggcg ccggtccgcc gggtcagctc accgaggacg
    14281 accagccctc cgaaggccag cgcgacgggc cgctgggcgg gccccgcccc cagcacggag
    14341 gcgagacatc cgagcgcgag gagtccggca cagccgggta cgaggaggac ggccgccggc
    14401 ggcgaggacc gggccggcgg ctgcaagggc gtcatggcgc tcccctgccg acgctgtccc
    14461 gcgcgtcctc gccccggtcc ggtgccggtc cggcggtgcg ggtgagcggg gagtccgccg
    14521 tgacggacgg gcgccagccg tgccgcccga gggcccggac cagtgcccgc accatccgcg
    14581 ggtcgaactg tccgccggca caccgctgga gctccgccag cgccgtcgcg acgggccggg
    14641 ccctgctgta ggagcgcgtg gacgtcatcg cgtcgaaggc gtcggcgacg gccaccaccc
    14701 gggccgactc ggggatccgg tcgccggcca gcccgtaggg atagccgctg ccgtccagcc
    14761 gttcgtggtg gtgcaggacg gcggcgcggg cctctcccag gaagcggatg ccgcgcacca
    14821 tctcgtgccc gtactcgggg tgcagttcga tcacccggcg ctcctcgggc gtcagcgggc
    14881 cgtccttgcg cagcagccgg gtgggcacgc cgagcttgcc cacgtcgtgc aggatcccgg
    14941 cgaagcgcag ggtctcgacg cgttcgtcgt ccatgcccag ctcgcgggcg atcatcatgg
    15001 aggcctggcc gacgcgttcg ctgtggccgc gcgtgtagcc gtccttgatg tcgacggcct
    15061 gcacgagggc gcggatggtc gcctggtgcg cggcccgctc acggtggtac tgggcgaagg
    15121 cccaccaggc cacgcacatc ggcagcagca cgagcagcgc ggccaccgga ccgtacgggc
    15181 tgcgccacag gacggccatc atgagcccgg cgagcccgtg cacggcgatc ggcgcgagcg
    15241 accgggagag cagtccccgc cacgcccggc tcggcggcac gtggtcggcg agagtcagga
    15301 tgccgccgtc cagcacggtg aggaccaggc agaaggcgag tacggccgcc ccggccggca
    15361 cgagggcgta cgggaaggcg ggctcgacga ccgcgtcccg gcccccgagc cgccagtgga
    15421 cacaggccgc ggcccacacg gcgagggtca gctgcgcggc ccgccacacg cgccgcagac
    15481 cgaggggacg gcgcggcacc ggggccagca gggctcccgg cagtgccacg agcgcggcgg
    15541 cgggcggcgg cagcaggaag gcgccggcga gcaggacggg gtagcaggtc ccgacgaagc
    15601 gggaccgcgc gaccagctcg gaccccgcgt acagccccgc cagcagcagc accgcccacc
    15661 agggcgcgtg caccgcgggc agcggtcgca ggcagagcag ggcggtgagg gcgacgacgg
    15721 ccacgtacac acgtgcccgc gccggtaccg cgtccatcag cccctcccct ggccacgcct
    15781 gtcaggctca ggagcctagg acggcggcgg ggaggccgcg ggcagataac ccgcggatta
    15841 gcacgtacga gtgacttctg gccgagtcgc gacgctcagg gcggctcagg actcctgcgg
    15901 agccgacgac gacggtgcgg ccgcgacgtc gtgttccggc acggactgcc cggaccggat
    15961 caggtccagc cgtcccatca ccttggcccg caggtcaccg ggcacgtcgt cctgcccgca
    16021 gcaccgcttg accagcttct tcacggcctg ctccagcccg tacttctcca ggcagggcga
    16081 gcactcctcg aagtggtgct cgaacttcac gcagtccgag tccggcatct ctttgtcgag
    16141 aaactcgtag agatgatcga ggatttcgct gcaatccgtc tcgtgcggct ctccgcagct
    16201 catgaccccg agcctttcgc ttcgttcgac tctccggcgc cggcggggac cagaccgcgg
    16261 tcgcgggcgt agtcctccag catgccgcgc agctgacggc gtccacggtg cagccgggac
    16321 atcaccgtac cgatgggtgt ccccatgatg tccgcgatct ccttgtaggc aaagccctcg
    16381 acgtccgcca gatacacggc gatacggaat tcctcgggga tcgcctggag cgcctgcttc
    16441 acgtccgagt cgggcaggtg gtcgagcgcc tgcgactccg cggagcgcag acccgtcgac
    16501 atgtgcgact cggcacgggc gagctgccag tcctcgatct cctcggccgc gctgcgctgg
    16561 ggttcgcgct gcttcttgcg gtacgagttg atgaaggtgt tggtgaggat gcggtacagc
    16621 cacgccttga ggttggtgcc ctcgcggaac tggtggaagg acgcgtacgc cttggcgtag
    16681 gtctcctgca ccaggtcctc ggcgtcggcc ggattacgcg tcatgcgcag cgcggccgag
    16741 tacatctggt cgaggaactc cagcgcgtcc cgctcgaagc gcgcgctgcg ctccgcggtc
    16801 gactccgcgc ccgtaccccg gccctcgggc tgctccgcct ggccgtgttc ggtccctgcg
    16861 tcggtcccag tgaccggacc cacctcctcc gatgtcgtcg tgaaaccgag accggtctca
    16921 ctcgaatcgg aggatagacg acgatccggt ccgcccgccg cccgaatagg ggcggtcttg
    16981 gcagcgtgca gcacggtcca gtccaggtcg gcgcggctgc tgcgactcgg gcagaaggct
    17041 gaacccatgc ggcggacttc ctctcctacg gcgtcggtgc tgattctcag caacgtacga
    17101 acggcacaac agtggccgtc cgccggtcat tcccaggcgt tcagccgagt gagccggccc
    17161 actgggccac gccgtcggtg atcagctcca gcgccctttc ctggctgatc tccgcccgtt
    17221 tgggcacggc gaagccgtgg tcgccgtacg gcacctcgat cagctcgtag gtccccccgg
    17281 gcgcctcggg gaactcctgc ggcctgccga aggggtcgtt gccgccctgg accacgaggg
    17341 tgggcacgcc ggccccgagc agctcgtcgg cgcgggactt ctccggcctg cccggcgggt
    17401 gcagggggaa gctgagggcg aggacggcgc gggcgcccag ttcgccggcg gtgcggcagg
    17461 cgacacgggc gccggcgctg cggccgcccg agatcaccgg caggccgggg gcggcgagcg
    17521 cgggccagac gccccgccac ccggtgtcga gggtcttcgg cgcgggcgcc agcttcctgc
    17581 ccgccacccg ccagggctgc tcgacgaggg ccacgctcac cccgtgggcg ggcagtgcgg
    17641 ccgccagcgc cttcaggtcg cgcgcctcga tgccgccgcc ggccccgtgg ctcacggcga
    17701 gcaccagccg gggctgcttc gcccggtgcc aggtgatgcg ggcggggccc gcatccgtct
    17761 cgaccgcctc tgtcacaacc tctgtcgcat ccgtcacgtc agaagagtgt gccctcttcc
    17821 ggtgcttcca gctcctcgag cagctccggt ccgttgttgc ggacgttgct cacggccgtc
    17881 gagacgggga aggcccgcat caggccggtg ggcgggggtg ccagcaggga ggtcagctcg
    17941 tcggggtcgg tgcgcgccgg atcgagccag tcgtcccagc ggtccggcgt cagcatcagc
    18001 ggcatccggg ggtggatgtc ggccagggcg tgcggaccgt cggccggggc gacggcgagt
    18061 ggtgtggtct cggcctcggt cgtgatcacc gagcacgtca cccaccaggc ctgcggatgg
    18121 tcgtcgggca gcgtcctgtc ccgccagaac tcgtagagcc cggccatggc gaacacggag
    18181 ccgtcggcgg gggtcacgaa gtacggctgc ttgcgcggcc gcttcttgcg cccttcgacc
    18241 tccaggtccc gctcctgttt gccggtgacc cactcgtagt agccgtcggc gggcaggatg
    18301 cagcgccggg tgctgaaggc gcggcggtag gagggcttct cgtggacggt ctccgcgcgg
    18361 gcgttgatca tccgggcgcc gccctcgggc gtcttggacc aggaggggac gaggccccac
    18421 ttcagcttcc gcagctggcg aaccggctcc gggtcctcga cgtctttcag gggacggtcc
    18481 aggacggcgt agacctcctt ggtgggggcc acgttgtagt cgggttccaa gctctccttg
    18541 ggctcccact tctcgatctc gaagattccc gcgagatcct cgggtcgacg actcgccgca
    18601 taccgtccgc acatacgtgc cacactgcca gaccccgcgc tagtacgagg agccctcccc
    18661 gaacatggac cacctcgcaa cggcctcgct cacctccctg tgggacgagg tctccggcat
    18721 ccagcccgat cccgacctgt gggtggtggt cgcgaccctg gtggcggcgc tcgccgtcgt
    18781 cgcgacgcgc ggatcgtggc ggatagcgcg caacgcgatc accatcgcgc acgagggcgg
    18841 tcacggcctg gtggccctgc tgaccggccg taccctcacc gggatcaccc tgcactcgga
    18901 caccagcggt ctgacggtga gccggggcaa gccgcacggc gtcggcatga tcctcaccgc
    18961 ggtcgccggt tacaccgctc cgccgctgct cggcctcggc ggcgccgcac tgctggcggc
    19021 cgggcgcatc acgctgctgc tgtggctggc gacggcgctg ctggtggccc tgctggtgat
    19081 ggtccgcaac gcgtacgggg tgctgacggt cgtggtcacc ggcggcacgt tcgtcctggt
    19141 gtcgtggctg gccgggccgc aggtgcaggc ggcgttcgcg tacgcggtgg tctggttcct
    19201 tctcctcggc ggagtgcgcc cggccttcga gctgcaggcc aagcggtcgc ggggcggcgc
    19261 cggcgactcg gacgccgacc agttggcgcg gctgacccac gcgccggcgg gagtgtggtt
    19321 cttcctcttc cacgcggtgt cgctgtgctc gctgatcggc ggggcgcgct ggctgctgga
    19381 gctgtgagac gccaggcgcc ctccacccgc tccgcatata tgcacggcaa gtgcactgtt
    19441 gcgctttcgg tcaggtttcg gcgcttttga tcaagatctc cgatcgtcct cagccattaa
    19501 agtgggcccc atgaccgtga accccacgca caccgccctc tggcccgccc cgcacgcgag
    19561 cggagccgtc gacgcgaccg tccacgtgcc cgggtccaag tcggtcacca accgcgccct
    19621 ggtgctggcc gccctcgcct ccgagcccgg ctggctgcgc cgcccgctgc gctcccgcga
    19681 caccctgctg atggccgagg cgctgcgcat gatgggcgtc gagatcgagg agggcgtcgg
    19741 ccccgagggc accggcgagt tctggcgggt catcccggcg gggctgcgcg gcccggccac
    19801 ggtcgacgtc ggcaacgccg gcacggtcat gcgcttcctg ccgccggtcg ccacgctggc
    19861 cgacggcgcc gtccgtttcg acggcgaccc gcggtcgtac gagcgtccgc tgcacggcgt
    19921 gatcgacgcg ctgcgcgtcc tgggcgcccg catcgacgac gacgggcgcg gcgcgctgcc
    19981 gctgaccgtg cacggcggcg gggccctgga gggcggcccg gtcgagatcg acgcgtcctc
    20041 ctcctcccag ttcgtcagcg ccctgctgct gtccgggccg cgcttcaacc agggcgtcga
    20101 ggtgcgccac accggttccg cgctgccctc catgccgcac atccgcatga cggtcgacat
    20161 gctgcgcgcg gtcggcgccc aggtcgacac ccccgagtcc ggcggcgagc cgaacgtgtg
    20221 gcgggtcacg ccgggtgcgc tgctcggccg ggacctgacc gtcgagccgg acctgtcgaa
    20281 cgcgcagccg ttcctggcgg cggcgctggt gaccggcggc aaggtggtga tccccgactg
    20341 gccgtcccgc accacccagc ccggcgaccg gctgcgcgag atcttcaccg acatgggcgg
    20401 ttcctgcgaa ctgacggact tcgggctcgt gttcaccgga tcgggtgcga tccacggcat
    20461 cgacgtcgac ctgagcgagg tcggcgagct gaccccgggg atcgcggccg tcgccgccct
    20521 cgcggactcc ccctcgaccc tgcgcggcgt ggcccatctg cggctgcacg agacggaccg
    20581 gctggccgcg ctcaccaagg agatcaacga actcggcggt gacgtcaccg agaccgccga
    20641 cggtctgcac atccgcccgc gccgtctgca cggcggcgtc ttccacacct acgacgacca
    20701 ccgcatggcc accgccggcg ccgtcctcgg tctcgcggtg gagggcgtgc agatcgagaa
    20761 cgtggcgacg accgccaaga ccctgcccga cttccccgac ctgtggaccg ggatgctcgg
    20821 ggcgtaggga cggatcgcca tgcgccgcta cggcaagcac accgacgagg acgacatccg
    20881 ctcccgcccc aaccgcaagg gcaaccgacc gcgcacccac atccggccca agcacgagga
    20941 cgccgccgag ggcctggtcc tcaccgtgga ccgcggccgg ctgacctgcc tcgtcgacga
    21001 ccgggtcgtc atggcgatga aggcgcgcga gctgggccgc aaggcggcga tcgtgggtga
    21061 ccgggtggcc ctggtcggcg acctca
//
