LOCUS       NZ_BMVQ01000007        21128 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces anthocyanicus strain JCM 4739 sequence07, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVQ01000007
VERSION     NZ_BMVQ01000007.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces anthocyanicus
  ORGANISM  Streptomyces anthocyanicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceoruber group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 428136)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:14:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,934
            CDSs (total)                      :: 7,858
            Genes (coding)                    :: 7,681
            CDSs (with protein)               :: 7,681
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 73 of 177
            Pseudo Genes (incomplete)         :: 130 of 177
            Pseudo Genes (internal stop)      :: 16 of 177
            Pseudo Genes (multiple problems)  :: 37 of 177
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:48:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 117992
            Orig. end                         :: 139120
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVQ01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            823..1359
                     /locus_tag="IE283_RS19910"
                     /old_locus_tag="GCM10010348_40260"
     CDS             823..1359
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971687.1"
                     /locus_tag="IE283_RS19910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40260"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_003971687.1"
                     /transl_table=11
                     /translation="MGKTALIVIDMINTYDHQDAESLIPAVESVLPNVTGLLDRARRQG
                     VPVIYVNDNFGEWRSHHGEILDKALSGPHSRLVEPLKPDESSLFVVKARHSVFFETPLT
                     YLLHQQGIDRLVLCGQVTEQCVLYSALDAHIRHLQVIVPRDAVAHIHADLADAALRMME
                     RNMGARVCDSGELWT"
     misc_feature    839..859
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     misc_feature    complement(856..870)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            complement(1401..1892)
                     /locus_tag="IE283_RS19915"
                     /old_locus_tag="GCM10010348_40270"
     CDS             complement(1401..1892)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971686.1"
                     /locus_tag="IE283_RS19915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40270"
                     /product="DUF5949 family protein"
                     /protein_id="WP_189284010.1"
                     /transl_table=11
                     /translation="MTSISTDPRPLRTADLGTLVIMSWSRETPDGDVPFLLACSLGDGE
                     GGPEAVPAAVEGLLSRSGLAVGGDTVLDATALPGLPIGLLVVPGAAALTMPGVNAQFVP
                     TPEWRAAADRRGYACLIFATRPWPGGEPGDGEAVAAFANDADTLSSAAQVVLSVRSLRG
                     "
     gene            complement(1935..2333)
                     /locus_tag="IE283_RS19920"
                     /old_locus_tag="GCM10010348_40280"
     CDS             complement(1935..2333)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971685.1"
                     /locus_tag="IE283_RS19920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40280"
                     /product="hypothetical protein"
                     /protein_id="WP_193485945.1"
                     /transl_table=11
                     /translation="MDRLLVDEPVEPARDVEAPAEGPAEPDALVETMDTEVRETGGIAA
                     RTGRAFHRVHTQVRGIGAAADGEEPARMHAGTVEAVRAGGAKAAEAAEAAVRRHFDDIR
                     GRLSRHGRPRAPVAPRSCEEGPGCPPVG"
     gene            2492..2857
                     /gene="rpfE"
                     /locus_tag="IE283_RS19925"
                     /old_locus_tag="GCM10010348_40300"
     CDS             2492..2857
                     /codon_start=1
                     /gene="rpfE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971684.1"
                     /locus_tag="IE283_RS19925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40300"
                     /product="resuscitation-promoting factor protein RpfE"
                     /protein_id="WP_193485947.1"
                     /transl_table=11
                     /translation="MICRRNDRQSDVRGSRGRRIRTAAVTLVAATALGAAGEAVAAPSA
                     PLRTDWDAIAACESSGNWQANTGNGYYGGLQFARSSWIAAGGLKYAPRADLATRGEQIA
                     VAERLARLQGMSAWGCA"
     misc_feature    complement(2503..2517)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.48"
                     /tool="antismash"
     misc_feature    complement(2509..2529)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.43"
                     /tool="antismash"
     gene            complement(3054..3893)
                     /locus_tag="IE283_RS19930"
                     /old_locus_tag="GCM10010348_40310"
     CDS             complement(3054..3893)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971683.1"
                     /locus_tag="IE283_RS19930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40310"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_106518338.1"
                     /transl_table=11
                     /translation="MTAQTARSQADEDEAAVLRLQDVSVRRFTPDQLILDGVNWTVRPG
                     EHWALLGANGAGKTTLLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVNSAQRV
                     PQDLTAHAVVLTGHSGTVQPLWRTYGEEVRLRARDLLLELGVKELADRPYGVCSGGQRA
                     RVLIARALMADPALLLLDEPFNALDLPSREDLVEAMHQLAEGRPRLATVTVTHHLEELS
                     PAVSHALLLREGRILSRGAVDEVLTGSLLTSCFGRDITVARRDGRWSAYSGRRVAGG"
     misc_feature    3916..3931
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            4100..5170
                     /locus_tag="IE283_RS19935"
                     /old_locus_tag="GCM10010348_40320"
     CDS             4100..5170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971682.1"
                     /locus_tag="IE283_RS19935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40320"
                     /product="lipoprotein"
                     /protein_id="WP_003971682.1"
                     /transl_table=11
                     /translation="MGRRCTARGSGRRRAGRVGGGLAALLAGLLVTGCAAFDTDDDVRR
                     ARELAAELYPGELEVVDARILFPETTGSEVTLSVEDDPDAAVRFRVDAGKDRCDGGPDC
                     TDALREAVDRARREARDLRAMREAFDGCGHPVLAADEKLTAPWIEARVSDGTLDEVLAR
                     AGACAQRWVTARAEQGPKEVPGWVTVNFAAPGTAEDLPAAKKRLPTVLRLTHGPRLAAL
                     AGKAYYVAAYPVGEDAGHTVDAASARLRIVSPLEERQAFSRRIDASVLPALRATYPEAV
                     TSGGAGMGVWRLEPGTVRRMRGYVLFCERPPADGERCPGDLAALVTSDPRGGDAEVVDV
                     LTDIRDERGVLRLPPQ"
     gene            complement(5211..5939)
                     /locus_tag="IE283_RS19940"
                     /old_locus_tag="GCM10010348_40330"
     CDS             complement(5211..5939)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016328090.1"
                     /locus_tag="IE283_RS19940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40330"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_016328090.1"
                     /transl_table=11
                     /translation="MRTTRLVPALLAALMAALLSALALSPTASAVEPRPGDGGPQPIIG
                     GGYAQNAPWAARLFSGGRQTCTSTIISPTWILTAKHCVSGGNLAFRIGSLDQGSGGTVA
                     NGVQTVTSPSADLALVRLDRSVSATYARLGQPGTVRVGQSVQVYGWGATSRCGSEINCQ
                     SQYLKVANVSVTQGCYDAYYGQAICARPVDGITAGGDSGGPMMAGGVQVGVASTSDRQT
                     TTAYTNVTAYRSWIQSVAGV"
     misc_feature    5994..6008
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            complement(6109..6861)
                     /locus_tag="IE283_RS19945"
                     /old_locus_tag="GCM10010348_40340"
     CDS             complement(6109..6861)
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324211.1"
                     /locus_tag="IE283_RS19945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40340"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_173943926.1"
                     /transl_table=11
                     /translation="MAAVFAAGVGAGAINSVVGSGTLITFPVLLATGLPPVTATVSNAL
                     GLIPGSISGAIGYRRELRGQRGRVLKFGSGALLGGLAGATLLLTLPADAFETVVPVLVG
                     LALLLVAFQPQIGRLVQRRRARTGTSPRRDGGPLLLTGLTLASVYGGYFTAAQGIIYLS
                     LMGMLLDEPLQRLNGVKNVLSAVVNTVAALFFLFAADFEWTAVGLLAVGSGLGGYVGAK
                     VGRHFSPTVLRILVVTVGTVALVQLLLR"
     misc_feature    6836..6851
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            7194..8396
                     /locus_tag="IE283_RS19950"
                     /old_locus_tag="GCM10010348_40350"
     CDS             7194..8396
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="IE283_RS19950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40350"
                     /product="ATP-binding protein"
                     /protein_id="WP_011031678.1"
                     /transl_table=11
                     /translation="MTEYTGNPLLWVALVALVAAAVLISRQRKAARALRQQVQGLRDHY
                     TELENDYGKSVQAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLSRLQNKYGDSALLQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGGRRDTASVYDVVRSAQGRIRHFRRVDILSQAD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINIRTVPKGICVVVDDAGVGMSDEER
                     ARADKLLATERASGVAGLGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     ELLTAMPEKKAPAPAPAAAPAARGTARPVPDGGPEAALTSSQTDGDGLPRRRRKRPMAI
                     VPGSASNPRAAGRSDSEQAKVMGAFQRGTQSGRVTEPDSPDNAGRTSDTPGASSEGHEV
                     S"
     gene            8393..8794
                     /locus_tag="IE283_RS19955"
                     /old_locus_tag="GCM10010348_40360"
     CDS             8393..8794
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="IE283_RS19955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40360"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_003971678.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFDKDDADRV
                     AAAMSGVQSLSRTLAFFCEDPSQTWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVAQLGKRLTTPPRENLGARS"
     gene            8791..9168
                     /locus_tag="IE283_RS19960"
                     /old_locus_tag="GCM10010348_40370"
     CDS             8791..9168
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="IE283_RS19960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40370"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_003971677.1"
                     /transl_table=11
                     /translation="MTGHDGWQPEAPELVRPYVITKGRGLPDEDDLSLITLVTAAAGQP
                     QRPARLSPEEQSLLDLCSAGYLSVAEIAGHTHFPLGVVRILLASLMEGGHLVTRPPVAR
                     ARLADKEILEEVLNGLRAKFG"
     misc_feature    8830..8832
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9143..9736
                     /locus_tag="IE283_RS19965"
                     /old_locus_tag="GCM10010348_40380"
     CDS             9143..9736
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="IE283_RS19965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40380"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_003971676.1"
                     /transl_table=11
                     /translation="MGSAPSLDERDYVRDGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAESVDDLKGVQGKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEHYGLDYAIAVNHFDGAPLRDQRALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRYLLDRTR"
     misc_feature    complement(9741..9756)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     misc_feature    9748..9759
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     misc_feature    9864..9878
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    9966..9983
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            10001..11128
                     /locus_tag="IE283_RS19970"
                     /old_locus_tag="GCM10010348_40390"
     CDS             10001..11128
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971675.1"
                     /locus_tag="IE283_RS19970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40390"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_106518341.1"
                     /sec_met_domain="indole_PTase (E-value: 4.6e-147, bitscore:
                     484.2, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAASTGADPQDASTLGSFTGGQLRRLGSVAGLSRADVETYAQVL
                     TDALGPVAQRPLSLAPPTRTFLSDDHTPVEFSLSFRPGAAPAMRVLVEPGCGATSLADN
                     GRAGLEAVRTMARRWHFTTDALDELLDLFLPPAPQGPLALWCALELRPGGVPGVKVYLN
                     PAVGGEERSAATVREALRRLGHHRAFDSLPQGSGYPFLALDLGNWTEPRAKVYLRHDNL
                     TAGRAARLSRADSGLVPTAVEGFFRTAAGPGSDASGLDGRPAQSCHSFTDPGAERPSGF
                     TLYIPVRDYVRHDGEALARASTVLHHHGMDASVLHRALAALTERRPEDGVGLIAYLALA
                     GQRDQPPRVTAYLSSEAYTVRPPVVETVRQPLSVG"
     gene            complement(11231..12529)
                     /locus_tag="IE283_RS19975"
                     /old_locus_tag="GCM10010348_40400"
     CDS             complement(11231..12529)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="IE283_RS19975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40400"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_003971674.1"
                     /sec_met_domain="FMO-like (E-value: 4.1e-82, bitscore:
                     270.9, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-09, bitscore:
                     31.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAMGHALKERGISFVCLEKAPDVGGIWRQPGAG
                     ERGPGYQSLHLNTARQLTGYADFPMPSDYPLYPRHDQVAAYLRSFAEWAGLLDHVELRT
                     EVLSVRQDSDGSWTVVSRDADGAQSARRFEQVVVASGHHTDPALPDPLPAGADSFAGTI
                     LHSLDYRDGGDFAGRRVVVVGLGASAVDIAADLSRHAERTLLSVRRGLHIVPKQVFGMS
                     LDEIAEAPWWNEMPFAERRRWVEQALLVARGRLSDYGLPEPDHPILSSATTLSDEILSR
                     IRHGAVTPKPAIASFESDRVVFTDGSSEAADTVVYCTGFHMTFPFLPPGCPVAADGAVE
                     LYRRIVPADRPGLYFVGLVRPAGALTRLVEAQAQWVARLVDGAAALPGTEEMREEISTY
                     LAGIVERYGRTRGASIQVDVSPYLAEFREPLPV"
     gene            complement(12641..13987)
                     /gene="paaK"
                     /locus_tag="IE283_RS19980"
                     /old_locus_tag="GCM10010348_40410"
     CDS             complement(12641..13987)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (101-352). E-value: 5.1e-20.
                     Score: 63.3. Matches aSDomain:
                     nrpspksdomains_IE283_RS19980_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971673.1"
                     /locus_tag="IE283_RS19980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40410"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_106518342.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-25, bitscore:
                     84.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTGTAPAPRRGEPLPHDLLDDAERLSREQLRELQLDRLRA
                     TLRHAYDNVELYRKKFDAAGVTPDDCRSLADLSRFPFTTKADLRDTYPFGMFAVPMADV
                     RRVHASSGTTGRATVVGYTENDLSMWADVVARSIRAAGGRPGHKVHISYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFERQGIDPRTS
                     SLQVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECVETKDGLHIWEDH
                     FYPEVVDPLTDAVLPGGEEGEIVFTSLTKEALPVIRYRTRDLTRLLPGTARPAFRRMRK
                     VTGRCDDMIILRGVNVFPTQVEEIVLRTPGVAPHFQMRLTERGRMDHMTVRVEARPDAA
                     PEQRDAAARAIAQGVKDGVGVTVEVEVVEPETLERSLGKIRRVWDQRGA"
     CDS_motif       complement(12902..12964)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS19980_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="IE283_RS19980"
                     /protein_end="362"
                     /protein_start="341"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQVE"
     aSDomain        complement(12932..13684)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS19980_AMP-binding.1"
                     /evalue="5.10E-20"
                     /label="IE283_RS19980_AMP-binding.1"
                     /locus_tag="IE283_RS19980"
                     /protein_end="352"
                     /protein_start="101"
                     /score="63.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ADVRRVHASSGTTGRATVVGYTENDLSMWADVVARSIRAAGGRPG
                     HKVHISYGYGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYM
                     LTLLDEFERQGIDPRTSSLQVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGV
                     AQECVETKDGLHIWEDHFYPEVVDPLTDAVLPGGEEGEIVFTSLTKEALPVIRYRTRDL
                     TRLLPGTARPAFRRMRKVTGRCDDMIILR"
     gene            complement(13984..14484)
                     /gene="paaI"
                     /locus_tag="IE283_RS19985"
                     /old_locus_tag="GCM10010348_40420"
     CDS             complement(13984..14484)
                     /EC_number="3.1.2.-"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971672.1"
                     /locus_tag="IE283_RS19985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40420"
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /protein_id="WP_161270401.1"
                     /transl_table=11
                     /translation="MSQATEQTPTEAMFSADEASRGLGIELVEHGEGTALVRMTVTPAM
                     VNGHRIAHGGFLFLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAEERVR
                     YGRSGIYDVSVRRGDEVVAEFRGRSRSVRDDGRDRSARDDAGSRDARQDTARETPGTTK
                     ESR"
     misc_feature    complement(14509..14524)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(14631..14644)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            14663..15649
                     /gene="paaA"
                     /locus_tag="IE283_RS19990"
                     /old_locus_tag="GCM10010348_40430"
     CDS             14663..15649
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031683.1"
                     /locus_tag="IE283_RS19990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40430"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_011031683.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPDAPDGLQEHFDATIARDQRIEPRDWMPDGYRKT
                     LVRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTERLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTDAQREMVQDAVNRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEESGHHDFGTPDWDELMR
                     VIKGDGPCNDRRMERRRTAHEEGAWVREAATAHAAKQAARAEKGAVA"
     gene            15646..15957
                     /gene="paaB"
                     /locus_tag="IE283_RS19995"
                     /old_locus_tag="GCM10010348_40440"
     CDS             15646..15957
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971670.1"
                     /locus_tag="IE283_RS19995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40440"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_003971670.1"
                     /transl_table=11
                     /translation="MTPETARKPDGRGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALT
                     HARDLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            15967..16794
                     /gene="paaC"
                     /locus_tag="IE283_RS20000"
                     /old_locus_tag="GCM10010348_40450"
     CDS             15967..16794
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="IE283_RS20000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40450"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_003971669.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVETTVPEGVDATA
                     LAAECVALADDALVSAQRLAEWVTRAPELEEEVALANIGLDLLGQARLLYSRAGQADGT
                     GRGEDAYAYFRDAGDFRNVRLTELPGGDFAFAVVRLLVLSSWRLAHFRRLETHPDPVLA
                     AVAAKGVKELTYHRQYAAEWCVRLGDGTDESHRRMRAALDEVAPYLGELHTAYDVRDEV
                     ADDLRQVTEAAGLPLPVYRPLPGSGRAGEHTEHLAPLLTELQGIARAHPEATW"
     gene            16788..17303
                     /gene="paaD"
                     /locus_tag="IE283_RS20005"
                     /old_locus_tag="GCM10010348_40460"
     CDS             16788..17303
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="IE283_RS20005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40460"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_030868899.1"
                     /transl_table=11
                     /translation="MVTRDPALADARRARHVAEQVPDPELPMLTLADLGVLRDVEVDGD
                     GTVVASLTPTYSGCPAMAEMRADVAARLRAAGYPRVEIRTVLDPPWTSDWITESGRGKL
                     AEHGIAPPGAAPRGPVSLVLSPTRPAVPCPRCGSADTEETSRFAATSCKALWRCRACRE
                     PFEYVKEI"
     gene            17303..18409
                     /gene="paaE"
                     /locus_tag="IE283_RS20010"
                     /old_locus_tag="GCM10010348_40470"
     CDS             17303..18409
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="IE283_RS20010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40470"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_003971667.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPVRTRRRPAFHRLRVAAVERLCADAAAVSFEIPDE
                     LAGEFVFAPGQSLTLRREVDGRDERRSYSICAPAGSAPRIGVRVVPGGLFSAWLVDEVR
                     PGDTVEVMAPTGLFTPDLSTPGHHVLVAAGSGITPMVSIAESVLAADDRSTVTLFYGNR
                     RTDTVMFADELADLKDLHPTRFHLAHVLSREPREAEVLSGRLDAGRLAALVGSLVDVER
                     ADHWWLCGPQGMVADAQQVLTGLGVPAGRVHRELFYADDEPVREVRHEESGPEGPVSEV
                     TITLDGRSTTSSLSRERSVLDGAQQTRPDLPFACKGGVCGTCRALVTDGSVDMRRNYAL
                     ETAEVDAGYVLTCQSYPVSEKLTVDYDS"
     gene            complement(18618..19835)
                     /locus_tag="IE283_RS20015"
                     /old_locus_tag="GCM10010348_40480"
     CDS             complement(18618..19835)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971665.1"
                     /locus_tag="IE283_RS20015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_40480"
                     /product="alginate lyase family protein"
                     /protein_id="WP_189284014.1"
                     /transl_table=11
                     /translation="MSSAHPRRHRRSRAVLLATLTAALTGALLTGPGSAIPRADAAPAA
                     FTHPGVTVSQGQLDFARAKVDAGAQPWKGAFDQMMASRYADLNRAPKPRAVVECGSYSN
                     PDYGCTDEREDAIAAYTNALAWYFTRDERYARKSIELMDAWSAVLRDHTNSNAPLQTGW
                     AGSSWPKAAEIIKYTYGGAWANSGRFATMLRDVYLPEIINGSNSNGNWELTMTEAAVGI
                     SVFLEDRASYDKAVARFRTRTAAYVYLNSDGELPKTVPSQHLDTRDKIVKYWQGQSTFV
                     TGLTQETCRDFTHTGYGISSISHIAETSRIQGQDLYGTDVGERLRHALGFQAKYQQGAA
                     VPSWLCGGKADLGLGPVTEVGYNALHNRLGFAMTNTQALTERTRPSGTNNLFVAWETLT
                     HGDNPA"
     misc_feature    complement(19867..19885)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.13"
                     /tool="antismash"
     misc_feature    19905..19920
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.74"
                     /tool="antismash"
ORIGIN
        1 cttcgacctc cgggcgacga ccgtgacgtt cggcctcgcc gccgtcgccc tggtcctgac
       61 gggatgggtc gtgcgcatgg cgttcgacgt ggcgcagcgg cggccggcct gggtcttcgt
      121 cctggtactc ggggcggtcg cggccgccct cctgagccgg cgcgcgcgga gccggggcgc
      181 cgccgcgcgg gcggcccttc gtaccacgga cgtcctggcc gcggccacgg cgacggcgct
      241 ggacgaactg gagcagggcc gcgcggtgga agaggtggag cacgcgtgcc cagaggaggc
      301 caccgcggtg gtccgcaccg agcacgagga gctcagcccc gatgagttcg aggaggcgat
      361 agcggacctg tgccggcgtg acggctgcac cgaggtcgag gtggtgggcg gagcgggcga
      421 tctcggcgcc gacgtgctgg cgacggctcc cgacggccgg cgggtcgtca tccagtgcaa
      481 gcgctacggc gacgacaaca aggtcggctc ccaggacctc cagcgcttcg gcggcacctg
      541 cttcaccgtg cacggggccg acgtggcggt cctcgtcacc agcaacgact tcaccgcacc
      601 ggccgccgag tacgccgcgt ggtgcggcat agtctgcgtg aacgaggagc ggctgcgcga
      661 ctggtgcgag ggcgggggac cggcgccctg ggagcggctc ctgcccgagg gcgacggaac
      721 ggagccgccc gagcaggcca cgtggtgaga gggagggccc accgacccgc ggtaggcggg
      781 tggagagggg tttcaccgcc gtccagtggc aacctgggcg gcatgggcaa gaccgcgctg
      841 atcgtcatcg acatgatcaa cacctacgat caccaggacg ccgagtccct gatccccgcc
      901 gtggaatccg tgctgccgaa cgtgaccggc ctgctggacc gggcgaggcg gcagggcgtc
      961 cccgtgatct acgtcaacga caacttcggg gagtggcgct cgcaccacgg cgagatcctc
     1021 gacaaggccc tctccgggcc gcactcccgg ctcgtcgagc cgctgaagcc cgacgagtcg
     1081 tccctcttcg tggtcaaggc acgccactcg gtgttcttcg agaccccgct cacctatctg
     1141 ctccaccagc aggggatcga ccggctcgtg ctgtgcgggc aggtgaccga gcagtgcgtg
     1201 ctctactcgg cgctggacgc ccacatccgc catctgcagg tcatcgtgcc gcgtgacgcg
     1261 gtggcccaca tccacgccga tctggcggac gcggcgctgc gcatgatgga gcggaacatg
     1321 ggcgcccggg tgtgcgacag cggcgagttg tggacgtgag acggcccgcc gccacccggc
     1381 ggcgggccgt gtgcccgacc tcagccgcgc aggctccgta cggacaggac gacctgcgcc
     1441 gcggaggaga gcgtgtccgc gtcgttggcg aaggcggcga ccgcctcgcc gtcgcccggc
     1501 tcgcccccgg gccaggggcg ggtggcgaag atgagacagg cgtacccccg ccggtcggcc
     1561 gccgcccgcc actcgggagt gggtacgaac tgggcgttga cccccggcat ggtgagggcc
     1621 gccgcacccg gtacgacgag caggccgatc ggcaggccgg gcagggcggt ggcgtcgagg
     1681 acggtgtcgc cgcccaccgc gagtccggag cggctcaaca acccctcgac ggcggccggg
     1741 accgcctccg ggccgccctc cccgtcgccc agcgaacagg cgaggaggaa ggggacgtcg
     1801 ccgtcgggcg tctcacgact ccaggacatg atgacgaggg tgccgaggtc ggcggttcgc
     1861 agggggcgcg ggtcagtgga gatcgaggtc accgcgaaac cgtaagcgcg cgcggcgacg
     1921 cgcccgcccg gccgtcaccc gactggagga caccccggcc cttcttcaca cgaacgaggg
     1981 gcgaccgggg ctctcggccg tccgtgccgc gacagccgtc cgcgtatgtc gtcgaagtgc
     2041 cggcgcacag ccgcctccgc cgcctccgcc gccttcgcgc cgcccgcgcg cacggcctcg
     2101 acggtcccgg cgtgcatccg ggccggttcc tcgccgtcgg ccgccgcgcc gatcccccgc
     2161 acctgggtgt gcacccggtg gaaggcgcgg ccggtgcgcg ccgcgatccc gcccgtctcg
     2221 cgcacctccg tgtccatcgt ctccaccagc gcgtccggct cggccgggcc ttcggcgggg
     2281 gcttcgacgt cccgggccgg ctcaaccggc tcgtcgacaa ggaggcggtc cacgactccc
     2341 tcgccgccga ggcggcggtg cccgacggcg cggggcgcgt gcggtcggcg ccgtgaggcg
     2401 gtgacgggcg ggggagggca cgtgctccga ctggcccaag gcgcggtggc cggtggggcg
     2461 accggtggtc acctggtgta acagtcttct tatgatctgt agacgaaatg atcgtcagag
     2521 cgacgtgcgc ggttcgcgtg gccgcaggat ccgcaccgcc gcggtaaccc tggtcgccgc
     2581 gaccgcactc ggggcggccg gcgaagcggt ggccgcgccc tcggcgcccc tgcgcaccga
     2641 ctgggacgcc atcgccgcgt gcgagtccag cggcaactgg caggcgaaca ccggcaacgg
     2701 ctactacggc ggcctgcagt tcgcacggtc cagctggatc gccgccggcg gcctcaagta
     2761 cgccccgcgc gcggacctcg ccacccgcgg cgagcagatc gccgtggcgg aacgcctcgc
     2821 ccgtctgcag gggatgtccg cctggggctg cgcctgacgg tgccaaaccg ggccccggcc
     2881 gcgccgggtt gaccggggta gcccgtgggt gtgcacttgc cgcccctcac caccgcgtcc
     2941 cgtttccgcc gagccgtgca cgggcagtcc ccggcggggg gagccgagcg gcggccccgg
     3001 acgtcacgta cgccgatacg tccggggccg tcctcgcccc cggcaccgtc gtgtcagccg
     3061 ccggcgacgc ggcggcccga gtaggccgac caacggccgt cgcgccgggc caccgtgatg
     3121 tcccggccga agcaggacgt cagcagggag ccggtcagga cctcgtccac cgcaccccgg
     3181 gacaggatcc ggccctcgcg cagcagcagg gcgtggctga cggccgggga cagctcctcc
     3241 agatggtgcg tgaccgtgac ggtggccagc cgcggcctcc cctcggccag ttggtgcatc
     3301 gcctcgacga ggtcctcgcg ggagggcagg tccagggcgt tgaagggttc gtccaggagc
     3361 agcagggccg gatcggccat gagcgcccgg gcgatcagga cccgcgcccg ctgcccgccc
     3421 gagcagaccc cgtacggccg gtcggccagc tccttgacgc cgagttcgag cagcaggtcg
     3481 cgggcccgca gccggacctc ctcgccgtac gtccgccaca ggggctgcac ggtgccgctg
     3541 tggccggtga gcaccaccgc gtgggcggtc aggtcctgcg gcacccgctg ggcggagttg
     3601 acgtggccga tgcgcgcccg cagctcacgg acgtccaccc ggccgagccg gctgccgagg
     3661 acctcgacgg tgcccgtggt ggggtgcatg agcgcgccga gcagccgcag cagggtggtc
     3721 ttcccggccc cgttggcccc cagcagcgcc cagtgctcgc ccggccggac cgtccagttg
     3781 acgccgtcga ggatcaactg gtccggtgtg aagcggcgca cgctcacgtc ctggagccgg
     3841 agcacggccg cctcgtcctc gtcggcctgg gagcgggctg tctgggcggt catgccgtga
     3901 ctccttcacg cgcggggcac ctctcggtca ccgcgaacac tagatgtact caccacgcgc
     3961 ctgccccggc cgtccgctcc ctggacgggg ctgcggcact ggcggcggca ctcaggacgc
     4021 ggatgagttc ccgtactcat ccgcggtgcc gggcacggct cctatcgtgg cgccgtcggt
     4081 gggacacgga gggggagcca tggggcgtcg gtgcactgcg cgggggagcg gacggcggcg
     4141 ggcggggcgc gtcggcgggg ggctcgcggc gctcctggcc gggctgctgg tcaccggctg
     4201 cgcggcgttc gacaccgacg acgacgtccg gcgggcccgg gaactggccg cggagctgta
     4261 ccccggcgaa ctcgaggtcg tggacgcccg gatcctgttc ccggagacca ccggctcgga
     4321 ggtcaccctg tcggtcgagg acgacccgga cgcggccgtc aggttccggg tggacgccgg
     4381 caaggaccgc tgcgacggcg gcccggactg caccgacgcc ctgcgcgagg cggtggaccg
     4441 ggcccggcgg gaggcccggg acctgcgcgc gatgcgcgag gccttcgacg gctgcgggca
     4501 cccggtcctg gccgccgacg agaagctgac ggctccgtgg atcgaggcac gggtgagcga
     4561 cgggacgctg gacgaggtcc tcgcccgcgc cggcgcctgc gcgcaacgct gggtcacggc
     4621 ccgtgcggaa cagggcccga aggaggtgcc cggctgggtg accgtcaatt tcgccgcccc
     4681 cggcacggcc gaggacctcc cggccgcgaa gaagaggctg cccaccgtcc tgcggctcac
     4741 ccacggcccg aggctcgccg ccctggccgg caaggcgtac tacgtggccg cgtacccggt
     4801 cggcgaggac gccggccaca ccgtcgacgc ggcctcggcc cgcctgcgga tcgtgtcgcc
     4861 cctggaggag cggcaggcct tctcccggcg gatcgacgcg tcggtcctgc ccgcgctgcg
     4921 cgcgacgtac ccggaggccg tgaccagcgg cggggccggg atgggggtgt ggcggctgga
     4981 gccggggacc gtccgccgca tgcgcgggta cgtgctgttc tgcgaacggc cgcccgcgga
     5041 cggcgaacgc tgccccgggg acctggccgc cctggtgacc tcggacccgc ggggtggcga
     5101 cgccgaggtc gtcgacgtcc tcacggacat ccgcgacgag cgcggggtcc tgcgcctgcc
     5161 tccgcagtga cggaggcggg cgcaggaccg gcgccggagg acgggagggg tcagacgccc
     5221 gccaccgact ggatccagga acggtaggcg gtcacgttgg tgtacgccgt ggtggtctgc
     5281 cggtcgctgg tcgaggcgac gcccacctgc acaccgccgg ccatcatcgg accgccggag
     5341 tcgccgcccg cggtgatgcc gtcgacggga cgggcgcata tcgcctggcc gtagtaggcg
     5401 tcgtagcagc cctgggtgac gctcacgttg gccaccttga ggtactggga ctggcagttg
     5461 atctccgagc cgcaccggga ggtcgctccc cagccgtaga cctgcacgct ctggccgacc
     5521 cgcaccgtgc ccggctgacc gagccgggca taggtggcgg agacggagcg gtcgagccgg
     5581 accagcgcga ggtccgccga ggggctggtg acggtctgga cgccgttcgc caccgtgccg
     5641 ccggagccct ggtcgaggct gccgatccgg aaggcgaggt tgccgccgct gacgcagtgc
     5701 ttggcggtga ggatccaggt gggggagatg atggtcgagg tgcaggtctg ccggccgccc
     5761 gagaacaacc gggccgccca gggggcgttc tgcgcgtagc cgccgccgat gatcggctgg
     5821 gggccgccgt caccgggccg gggctccacc gccgaggcgg tcggggagag ggcgagggcg
     5881 gacagcagcg cggccatgag ggcggccagc agggcgggga cgagtctcgt tgttcgcaag
     5941 gctcctcgat tccgacgaca cgcgcgtgcg cgcgtgctga tgtgtggggg cgcccacagc
     6001 atgtcgggcc cggaccccgg ccgggcagtc ccggcttcgc ataacgcggc gttatgcccg
     6061 gtggacggga acggccgggg agtgcggcgg cgttcggggc cggagcacct accggagcag
     6121 cagttgcacg agggccaccg tgccgaccgt cacgaccagt atccgcagga ccgtggggct
     6181 gaagtggcgg cccacctttg cgccgacgta accgccgagg cccgagccga ccgcgaggag
     6241 cccgacggcg gtccactcga agtccgcggc gaagaggaag aagagcgcgg ccacggtgtt
     6301 gacgacggcg gacaggacgt tcttgacccc gttgagccgt tgcaggggtt cgtccaggag
     6361 catgcccatc agggagaggt agatgatccc ctgggccgcg gtgaagtagc cgccgtagac
     6421 actggccagc gtcaggccgg tgaggagcag cggaccgccg tcccggcggg gggaggtgcc
     6481 ggtgcgggcc cggcggcgct ggaccagcct gccgatctgc ggctggaacg ccaccagcag
     6541 cagcgcgagg cccaccagga ccggcacgac ggtctcgaag gcgtcggcgg gcagggtcag
     6601 caggagagtg gcgcccgcga ggccgcccag cagcgctccg gagccgaact tcaggacgcg
     6661 cccgcgctgg ccgcgcagtt ccctgcggta gccgatggcc ccgctgatgg agccggggat
     6721 caggccgagc gcgttggaga cggtggcggt gaccggcggc aggcccgtgg ccagcagcac
     6781 gggaaaggtg atgagcgttc cggagccgac cacgctgttg atggcgccgg ccccgacgcc
     6841 ggccgcgaac accgcggcca tggcctccgg tgtcaccccg tgccgtcccg agccggaccc
     6901 gtactcggcc ggaaggtgtc ttgtgcatct ttcacggggc cgactgtacc catcactcga
     6961 aaccgggtgt ttgccggtct caaccggtct tgcctgggcg cttcttgacg tcaattcacc
     7021 tgatcatgcg gtgatacgat caccgcgttt gcggagcggg cggacgggtg aaagacggca
     7081 tccccgacat gaggggcagc ccgggcagct acccccggcg cgggcactcc accgggccgc
     7141 ccgcacggac gggaattcag caagccggct gtcagtcgcc tgaagagagt cttatgacgg
     7201 aatacacagg gaaccccttg ctctgggtcg ccctcgtcgc cctcgtcgcc gccgccgtgc
     7261 tcatcagccg ccagcgcaag gcggcccggg cgttgcggca gcaggtccag gggctcaggg
     7321 atcactacac cgagctggag aacgattacg ggaagtccgt acaggcggcc caggagcggg
     7381 ccgaggacga gacgaagacc gtgctgaagt ccgcgatgcg gacgcttcag ggtctcgcgg
     7441 ccgaacagca gctggtgctc tcccggctcc agaacaagta cggcgactcg gccctcctcc
     7501 aggacctgct ggagatcgac cacaccaact cgcagttcgg gcggcgggcg cagtccatcg
     7561 ccgtgctgtg cgacggctgg ctcggcggtc ggcgcgacac cgcctcggtc tacgacgtgg
     7621 tgcgcagcgc ccaggggcgc atccgccact tccgccgggt ggacatcctc tcccaggccg
     7681 acttcggcat caccagccgg gccgtcgaac ccgtggccct ggctctggcc gagctgctcg
     7741 acaacgccac gagctactcc agcccggaca ccgtcgtcga gatcaacatc cggaccgtgc
     7801 ccaagggcat ctgcgtcgtg gtcgacgacg ccggtgtcgg catgagcgac gaggagcggg
     7861 cccgcgccga caagctgctc gccaccgagc gggcctcggg cgtggcgggg ctcggcaacc
     7921 cgccgcagtt cggcttcgcc gtcatcggcc tgctgtgcga acgattcggt ttcgaggtgt
     7981 cggtggactc ctcctctccc tacggaggtg tacgggcggt ggtcctgctg ccgcacgaac
     8041 tgctcaccgc catgccggag aagaaggccc ccgcccccgc tcccgccgcc gcccccgcgg
     8101 cccgcggcac ggcccggccg gtcccggacg gcggaccgga ggccgcgctc acctcctccc
     8161 agaccgacgg cgacggtctg ccccggcgcc gccgcaagcg gccgatggcc atcgtgcccg
     8221 gcagcgcgtc caacccccgc gccgcgggcc gctccgactc cgagcaggcg aaggtcatgg
     8281 gtgccttcca gcgcggaacg cagtccggcc gggtcaccga accggacagc ccggacaacg
     8341 ccggccggac gagcgacaca cctggtgcaa gcagcgaagg acatgaggtc tcgtgaacga
     8401 cgatctgtca tggatgctcg acagcgccct ggagattccg ggcgccctgc acgcggtcct
     8461 gatatccgcc gacggcctct tgatggcccg gacgcaggac ttcgacaagg acgacgcgga
     8521 ccgggtcgcg gccgccatga gcggtgtgca gtcgctcagt cgcaccctgg ccttcttctg
     8581 tgaggacccc agccagacct ggcggcagac cctggtcgag ttcgacggcg gctgggtctt
     8641 cctgatctcc gccggcgagg gcgcctacct cggcgtgtcc gcctccccgg aggtcgacat
     8701 ggcggacatc accttccgga tgcagcagct cgtcgcccag ctcggcaagc ggctgacgac
     8761 accgccgcgc gagaacctgg gcgcccgctc atgaccggcc acgacggctg gcagcccgag
     8821 gcgcccgaat tagtgcggcc gtacgtcatc accaagggcc gcggcctgcc cgacgaggac
     8881 gacctctccc tcatcacgct ggtcaccgcc gccgccgggc agccgcagcg gccggcccgg
     8941 ctgtcccccg aggagcagag cctgctcgac ctctgctccg ccggctacct ctcggtcgcc
     9001 gagatcgccg ggcacaccca cttcccgctg ggcgtcgtaa ggatcctgct ggcctccctg
     9061 atggaaggcg ggcacctcgt gacccgtccg ccggtggccc gcgcccgcct cgcggacaag
     9121 gagatactgg aggaggtgct caatgggctc cgcgccaagt ttggatgagc gggactacgt
     9181 acgcgacgga gcgacccaga cggcggtgaa gatcctcgtc gtcgggcact tcgcggtggg
     9241 caagaccacc ctcatcggct ccatctccga gatcgagccg ctgtccaccg aggagacgat
     9301 gacgcaggcc gccgagtcgg tcgacgacct caagggggtc cagggcaaga ccaccaccac
     9361 ggtcgccatg gacttcgggc gcctgaccat cagcgaccgc gtcgtgctct acctcttcgg
     9421 cacccccggc cagcagcgct tcgtgcagat gtgggaggac atggcccgcg gcgcgctcgg
     9481 cgccctggtg ctggtcgacc cggagcggct ggcggactcc ttcccggtga tcgacctcat
     9541 cgagcactac ggacttgact acgccatcgc cgtcaaccac ttcgacggcg cgccgctgcg
     9601 cgaccaacgg gcactgcgcg aggcgctcga cctgctcgac gacacccccg tcgtcacctg
     9661 cgacgcccgt gacgagaagt cctcggccgc cgcgctgacc acgctcgtcc gctacttgct
     9721 ggaccgcacc cgttaggagt gggaagcaga cgtgaacgcc cacgacaccg ccccggtgct
     9781 ccggccgcgg tgatccgcgc aacacctccc caacccgccc caatcgcatg aagatcgaac
     9841 ggcacgggta gtgagcaacg cggtactcaa gttgcttacg agtcaaagga ggtgtcgtgg
     9901 accacatatc cacgaacgcc gctctcccgg cgccgaaacc cccggtaccc gccccccgag
     9961 gcgggtatcg ctttgtgcgg ctccggccgg aggcggaccg ttgagggccg cgtcgacggg
    10021 cgcggacccg caggacgcat ccacgctcgg ctctttcacc ggcggccagt tgcgaagact
    10081 cggctcggtc gccggtctgt cccgcgccga cgtcgagacc tacgcacagg tcctgaccga
    10141 cgcattgggc ccggtggccc agcggccgct gagcctggcg ccgcccaccc gcaccttcct
    10201 gtcggacgac cacacccccg tggagttctc cctctccttc cggcccgggg cggcgcccgc
    10261 catgcgggtc ctcgtggaac cgggctgcgg tgcgaccagc ctggccgaca acggccgtgc
    10321 cggtcttgag gcggtccgca cgatggcgcg gcgctggcac ttcaccaccg acgccctcga
    10381 cgaactcctg gacctgttcc tgccgcccgc tccgcagggc cccctcgccc tgtggtgcgc
    10441 cctggaactc aggcccgggg gtgtaccggg cgtcaaggtc tatctgaacc cggcggtggg
    10501 cggggaggaa cgttccgccg cgacggtgcg cgaggccctg cgccggctcg ggcaccaccg
    10561 ggccttcgac agcctccccc agggcagtgg atacccgttc ctcgccctgg acctcgggaa
    10621 ctggaccgag ccccgggcga aggtctacct gcgccacgac aacctcacgg ccggtcgggc
    10681 cgcacggctg tcccgcgcgg actcgggcct cgtgccgacc gcggtcgagg gtttcttccg
    10741 caccgccgcg ggtcccgggt ccgacgcgag tgggctcgac gggcggcctg ctcagtcctg
    10801 ccactccttc accgaccccg gcgcggagcg gccgagcggc ttcaccctgt acatcccggt
    10861 tcgtgactac gtccggcatg acggggaggc cctggcgcgg gcgtccaccg tgctgcacca
    10921 ccacggcatg gacgcctccg tgctccaccg cgccctggcc gccctcaccg agcggcggcc
    10981 cgaggacggg gtgggcctga tcgcctacct ggccctcgcc ggccaacggg accagccgcc
    11041 gcgggtgacg gcctacctct cctcggaggc ctacacggtc cggccgccgg tcgtggagac
    11101 cgtccgccaa ccgctgtcgg tcggctgaac ggaacgtccg cccgcgaaac agggcccccg
    11161 gcgcgatccg ccgggagccc tgggcgcggt cacggccggg cgtgaccgcc gaccgcgtcg
    11221 tgcgggacgg tcacacgggc agtggctccc ggaactccgc caggtaggga ctcacgtcga
    11281 cctggatcga ggcgccgcga gtgcggccgt aacgttcgac gatgccggcc aggtacgtac
    11341 tgatctcctc gcgcatctcc tcggtgcccg gcagcgcggc ggcgccgtcg acgaggcgcg
    11401 ccacccactg ggcctgggcc tccaccagcc gggtgagggc acccgcgggc cgcaccagtc
    11461 ccacgaagta cagaccgggc cggtcggccg ggacgatccg ccggtagagc tcgaccgcgc
    11521 cgtcggccgc gaccgggcag cccgggggca ggaaggggaa ggtcatgtgg aatccggtgc
    11581 agtagacgac cgtgtcggcg gcctcggagc tgccgtccgt gaacacgacc cggtcgctct
    11641 cgaacgaggc gatcgcgggc ttcggggtca ccgcaccgtg ccggatccgg ctgaggatct
    11701 cgtccgagag ggtcgtcgcg gaggagagga tcgggtggtc gggctcgggc aggccgtagt
    11761 ccgacagcct gccccgggcc accagcaggg cctgctccac ccacctgcgc cgctcggcga
    11821 agggcatctc gttccaccac ggggcttcgg cgatctcgtc gagggacatc ccgaagacct
    11881 gcttgggcac gatgtgcagc ccccggcgca ccgacagcag ggtccgctcc gcgtgccggg
    11941 agaggtccgc cgcgatgtcc accgcggagg ccccgaggcc caccacgacg acgcgccggc
    12001 cggcgaagtc gccgccgtcg cggtagtcga gggagtgaag aatcgttccg gcaaaggagt
    12061 cggcgccggc cggaagggga tcgggcaggg ccgggtcggt gtggtgcccc gaggcgacga
    12121 ccacctgctc gaaccggcgt gcggactgcg cgccgtccgc gtcccggctg acgaccgtcc
    12181 agctgccgtc cgagtcctgg cgcacggaca gcacctcggt ccgcagctcc acgtggtcga
    12241 ggagccccgc ccactcggcg aaggaccgca gataggcggc gacctggtcg tgccggggat
    12301 agagggggta gtcggacggc atcgggaagt ccgcgtaacc ggtcagctgc ctggcggtgt
    12361 tcaggtgcag ggactgatag cccggacccc gctcaccggc ccccggctga cgccagatcc
    12421 cgccgacgtc gggcgccttc tccaggcaga cgaaggagat gccgcgctcc ttgagggcat
    12481 ggcccatcgc cagccccgac aggcctgcac cgatcacaca cacacgcacg ggatgtcccc
    12541 ccaggatgta ctcaacctcc cccgatcatg tctttactgc ccatccgttt cttctcgcac
    12601 accggcacga ccggtgaacg gacgtgtccg tgctcacgtt tcacgcgccc cgttggtccc
    12661 acacccggcg gatcttgccg agcgagcgct ccagggtctc cggctccacg acctccacct
    12721 ccacggtcac gcccacaccg tccttgacgc cctgggcgat cgccctcgcg gcggcatcgc
    12781 gctgctcggg agcggcgtcg ggccgggcct ccacccgcac cgtcatgtgg tccatgcggc
    12841 cgcgttcggt gagccgcatc tggaagtgcg gggcgacgcc cggcgtgcgc agcacgatct
    12901 cctcgacctg ggtggggaag acgttcaccc cgcgcaggat gatcatgtcg tcgcagcggc
    12961 cggtgacctt ccgcatccgg cggaaggcgg ggcgcgcggt gcccggcagc aggcgggtca
    13021 ggtcgcgcgt gcggtagcgg atcaccggga gcgcctcctt ggtgagggag gtgaagacga
    13081 tctcgccctc ctcgcccccg ggcagcacgg cgtccgtgag cgggtccacg acctcggggt
    13141 agaagtggtc ctcccagatg tgcagcccgt ccttggtctc gacgcactcc tgtgccacgc
    13201 cggggccgat cacctcggac aggccgtaga tgtcgacggc gtggatgtcc atgcgctcct
    13261 cgatctcgcg ccgcatctcc tcggtccacg gctcggcgcc gaagatgccg acctggaggg
    13321 agctggtgcg cggatcgatg ccctggcgct cgaactcgtc gagcagggtg agcatgtagg
    13381 acggggtgac catgatgatc tcgggccgga agtcctggat gatctgcacc tggcgcgccg
    13441 tcatgccgcc ggaggccggg atcaccgtgc agccggcgcg ctcggccccg tagtgggcac
    13501 cgagaccgcc ggtgaacagg ccgtagccgt aggagatgtg gaccttgtgg ccggggcggc
    13561 cgcccgcggc gcggatcgaa cgggctacca cgtccgccca catggacagg tcgttctcgg
    13621 tgtacccgac gacggtggcg cggccggtgg tgccgctgga ggcgtgcacg cgccgcacgt
    13681 cggccatcgg gacggcgaac atgccgaagg ggtaggtgtc ccgcaggtcc gccttggtgg
    13741 tgaaggggaa cctggacagg tcggccaggc tgcggcagtc gtcgggggtc accccggcgg
    13801 cgtcgaactt cttgcggtac agctccacgt tgtcgtaggc gtgccgcagg gtcgcgcgca
    13861 ggcggtcgag ctggagctcc cggagctgct cgcgggacag gcgctcggcg tcgtccagca
    13921 ggtcgtgggg gaggggctcg ccccgtcggg gtgccggggc cgtcccggtc gtcggctcgc
    13981 tgctcatcgc gactccttcg tcgtgcccgg cgtctcgcgc gccgtgtcct gccgcgcgtc
    14041 gcggctgcct gcgtcgtccc gcgcactccg gtcgcgcccg tcgtcccgca cgctgcggct
    14101 gcgcccccgg aactccgcga ccacctcgtc gccgcgccgc acgctcacgt cgtagatccc
    14161 gctgcgtccg taccggaccc gctcctcggc gcgggccacg agcacgtcgc cctcgcgggc
    14221 cggggcgacg aagacgatgt cggcgccggc cgccacggtc accggcccgt ggctgttgca
    14281 ggcgcaggcg aaggcggtgt cggccagcag gaaaaggaac cctccgtggg cgatccggtg
    14341 tccgttcacc atcgccgggg tcacggtcat acggaccagc gcggtcccct ccccgtgctc
    14401 caccagctcg atcccgagcc cccgggaggc ctcgtccgcg gagaacatcg cctccgtcgg
    14461 cgtctgctca gtggcctgcg acaccgtatc caccaccctg tctcccgacc gaccattcgg
    14521 ttagcgcgcg gcaaggccaa gtaatccagc cacgcggcgg gactgtcaag agagtgtggc
    14581 cggcgaggtc cggctcttgc ccggcgcacg gaaacacgtc acactgatac cgaacgaatg
    14641 gtcggttggg aagctggtga cgatgaccac gacacacgcc gccgaggcgc cgcccccgga
    14701 cgcgccggac gggctccagg agcacttcga cgcgacgatc gcgcgcgacc agcgcatcga
    14761 gccgcgggac tggatgcccg acgggtaccg caagacgctg gtacggcaga tcgcccagca
    14821 cgcgcactcg gagatcatcg gcatgcagcc cgagggcgag tggatcaccc gggccccgtc
    14881 gctgcgccgc aaggcgatcc tgttcgccaa ggtccaggac gaggccgggc acgggctgta
    14941 cctgtactcg gcggccgaga cgctcggcgc ggaccgcgac gacctcaccg agcggctgat
    15001 cgaggggcgc cagaagtact cgtcgatctt caactacccg accctgagct tcgccgacgt
    15061 cggcgtgatc ggctggttcg tggacggcgc cgcgatctgc aaccaggtgc cgctgtgccg
    15121 cagctcctac gggccctacg cgcgcgcgat ggtgcgcatc tgcaaggagg agtccttcca
    15181 ccagcggcag ggctacgagc tgctgatgac gatgatgcgc ggcaccgacg cccagcgcga
    15241 gatggtccag gacgcggtga accgctggtg gtggccgtcc ctgatgatgt tcggcccgcc
    15301 cgacgacgcc tcgcccaact cggcgcgctc catggcctgg aagatcaagc ggcacagcaa
    15361 cgacgaactg cgccgccgct tcgtcgacat gaccgtcccg caggccgaga agctcggcgt
    15421 caccctgccc gacccggagc tgcgctggaa cgaggagagc ggtcaccacg acttcggcac
    15481 ccccgactgg gacgagctga tgcgcgtcat caagggcgac ggcccctgca acgaccggcg
    15541 gatggagcgg cggcgcaccg cccacgagga gggcgcctgg gtgcgtgagg cggccaccgc
    15601 ccacgccgcc aaacaggccg cccgcgcgga gaagggagcg gtggcatgac ccccgagacg
    15661 gcccggaagc ccgacgggcg gggctggccg ctgtacgagg tgttcgtgcg cggcaagcgc
    15721 ggcctcaacc acgtccacgt cggctcgctg cacgccgccg acgacgccat ggcgctcacc
    15781 cacgcccgcg acctctacac ccggcgcaac gagggcgtga gcatctgggt ggtgcgctcc
    15841 gagcacatcg ccgcctccac ccgggacgag aaggacccct tcttcgcccc cagcgccgac
    15901 aaggtctacc gccacccgac cttctacgac atccccgacg acgtcccgca catctaggag
    15961 cagggtatga gcgacgacca cgtctacctc accctggccg aggggcacga ggacgacacc
    16021 cgctgggcct acggcaccgg cttcgaggac ccgctgcacg gcgtcgagac caccgtgccc
    16081 gagggcgtcg acgccacagc gctggccgcc gagtgcgtcg cgctcgccga cgacgccctg
    16141 gtgagcgccc agcggctggc cgagtgggtc acccgggcgc cggagcttga ggaggaggtg
    16201 gcgctggcca acatcgggct cgacctgctc ggccaggccc gcctgctgta ctcgcgcgcc
    16261 ggtcaggccg acggcaccgg ccgcggcgag gacgcgtacg cctacttccg cgatgccggc
    16321 gacttccgca acgtccgcct gaccgaactc ccgggcggcg acttcgcgtt cgccgtcgtg
    16381 cggctgctgg tgctctccag ctggcggctg gcccacttcc ggcggctgga gacacacccc
    16441 gacccggtgc tcgcggcggt cgccgccaag ggcgtcaagg agctgaccta ccaccggcag
    16501 tacgccgccg agtggtgcgt gcgcctgggc gacggcaccg acgagtcgca ccgccggatg
    16561 cgcgccgcac tggacgaggt cgccccgtac ctgggtgagc tgcacacggc gtacgacgtc
    16621 cgggacgagg tcgccgacga cctgcgccag gtcacggagg ccgccgggct gcccctgccc
    16681 gtgtaccggc cgctgcccgg ctcgggccgg gccggcgagc acaccgaaca cctggcgccg
    16741 ctcctgaccg agctgcaggg catcgcccgc gcccacccgg aggcgacatg gtgacccggg
    16801 acccggcgct cgcggacgcg cgccgcgccc ggcacgtcgc cgagcaggtg cccgaccccg
    16861 agctgcccat gctgaccctc gccgacctcg gcgtgctgcg cgacgtcgag gtggacgggg
    16921 acggcaccgt ggtcgccagc ctgaccccca cctactcggg ctgcccggcc atggccgaga
    16981 tgcgggcgga cgtcgccgcg cggctgcgcg cggcgggcta cccgcgtgtg gagatccgca
    17041 ccgtcctgga cccgccctgg accagcgact ggatcaccga gtccggccgc ggcaagctcg
    17101 ccgagcacgg aatcgccccg cccggcgccg caccccgcgg cccggtctcc ctggtgctgt
    17161 cgcccacccg gcccgcggtg ccctgccccc gctgcggctc ggcggacacc gaggagacct
    17221 cccgcttcgc cgccacgtcc tgcaaggcgc tgtggcgctg ccgggcctgc cgcgagccgt
    17281 tcgagtacgt caaggagatc tgatggcccc gaccgcccct gtcccggcgg ccccggtgcg
    17341 cacccgccgc cggcccgcct tccaccgtct gcgcgtcgcg gccgtcgagc ggctgtgcgc
    17401 ggacgcggcg gccgtgagct tcgagatccc cgacgagctg gccggggagt tcgtcttcgc
    17461 gcccggtcag tcgctcaccc tgcggcgcga ggtggacggc cgggacgagc gccgctccta
    17521 ctcgatctgc gcaccggccg gttcggcgcc gcgcatcggg gtccgcgtgg tgccgggcgg
    17581 actgttctcg gcgtggctgg tcgacgaggt gcggccgggc gacaccgtcg aggtgatggc
    17641 gcccaccggc ctgttcacac ccgacctttc cacccccggc caccacgtcc tggtcgcggc
    17701 cggttcgggc atcacgccga tggtgtccat cgccgagtcg gtgctcgccg ccgacgaccg
    17761 ctccaccgtc accctcttct acggcaaccg ccgcacggac accgtgatgt tcgccgacga
    17821 gctggccgac ctgaaggacc tccacccgac ccgcttccac ctcgcccacg tgctctcccg
    17881 tgaaccccgg gaggccgagg tgctctccgg ccgcctggac gcaggacggc tcgcggcgct
    17941 cgtcggctcc ctggtggacg tggagcgggc agatcactgg tggctgtgcg gaccgcaggg
    18001 catggtcgcc gacgcccagc aggtcctgac cggcctcggc gtcccggccg ggcgcgtcca
    18061 ccgggagctg ttctacgccg acgacgagcc cgtgcgggag gtgcgccacg aggagagcgg
    18121 ccccgagggc cccgtcagtg aggtcacgat caccctggac ggccgctcga cgacctcctc
    18181 gctctcccgc gagcggtcgg tgctcgacgg ggcccagcag acccgccccg acctgccctt
    18241 cgcctgcaag ggcggggtct gcgggacctg ccgggcgctc gtcaccgacg gcagtgtcga
    18301 catgcgccgc aactacgcgc tcgaaaccgc cgaggtcgac gcgggctacg tcctgacctg
    18361 ccagtcgtac ccggtctccg agaaactgac cgtggactac gacagctgac cgggtgacac
    18421 cccgcccgag gctagggggt gtcgtttgga tcttgccggg gtcgcggggt ctggcacgcg
    18481 catctgcggc gttgtcgtcg gttgccaggg ctccgccctg tcgccctcct ccgccttgca
    18541 gctgcacgca ccagaccccg ctcgggccgg ccacaaggca ccgtcggccg cggccggcct
    18601 gatccaaacg acacccccta ggcggggttg tcgccgtggg tgagcgtctc ccaggcgacg
    18661 aagaggttgt tcgtgcccga ggggcgggtg cgctcggtca gggcctgggt gttggtcatg
    18721 gcgaacccga ggcggttgtg cagggcgttg tagccgacct cggtcaccgg gcccaggccg
    18781 aggtcggcct tgcccccgca cagccagctc gggacggccg cgccctgctg gtacttggcc
    18841 tggaagccga gcgcgtgccg cagccgctcg ccgacgtcgg tgccgtacag gtcctggccc
    18901 tggatccggc tggtctcggc gatgtgcgag atggacgaga tgccgtaccc ggtgtgggtg
    18961 aagtcccggc aggtctcctg ggtgaggccg gtgacgaagg tggactggcc ctgccagtac
    19021 ttgacgatct tgtcccgggt gtcgaggtgc tggctcggca cggtcttcgg cagctctccg
    19081 tcggagttca ggtacacgta cgcggccgtg cgggtgcgga acctggccac ggccttgtcg
    19141 taggacgccc tgtcctccag gaacacggag atgccgacgg cggcctccgt catcgtcagc
    19201 tcccagttgc cgttggagtt ggagccgttg atgatctcgg gcaggtagac gtcgcggagc
    19261 atggtggcga agcggcccga gttcgcccag gcgccgccgt acgtgtactt gatgatctcg
    19321 gcggccttgg gccaggacga cccggcccat ccggtctgca gtggcgcgtt gctgttggtg
    19381 tggtcccgga gcacggcgga ccaggcgtcc atcagctcga tggacttgcg agcgtacctc
    19441 tcgtcccggg tgaagtacca ggccagcgcg ttggtgtagg ccgcgatcgc gtcctcgcgc
    19501 tcgtcggtgc agccgtagtc ggggttggag tacgaaccgc actcgaccac cgcgcggggc
    19561 ttcggggcgc ggttcaggtc cgcgtaccga cttgccatca tctggtcgaa ggcgcccttc
    19621 cagggctggg ccccggcgtc gaccttggcg cgggcgaagt cgagttggcc ctgggagacg
    19681 gtgacgccgg ggtgcgtgaa cgcggccggt gcggcgtccg cgcgggggat ggccgagccg
    19741 ggcccggtca gcagggcgcc ggtgagtgcg gcggtgaggg tggcgaggag gacggcgcgg
    19801 gaccggcggt gacggcgcgg gtgagcagag gacatgtggg gggtccatcc gttcgggtat
    19861 gtgaacgttg agtgtcgttc tgaacgttcg actgggcggt gacgataggt agagaccaat
    19921 ggggcgtcaa gaggccacgc aggaacacgc ggagttccgg gcgggccggg ctcggcgaac
    19981 actatgaacg caacggccga aggggtggct ccggatccgg gggattccta acatccccgc
    20041 tcgcagcgca acttcgcgcc ggcccgcagc agcacgtaca ggagccgcac cttgaccaca
    20101 ccccccgctc ccgcgcacga cacccggccc acccaccgca gaagccgccc ggcggtggtg
    20161 gccgccgcgc tcgccgccgt cttcctcggc accctcggca acgtctccgc cgcccccgcc
    20221 cgagcggccg gagagccgcc tgccgggcag tcggcggccg gacagccgtc ggtggccgac
    20281 tgcccgcccg ccctcgccgg gaaggccacc tgctacaccg gccgggacgc gggcggcgcc
    20341 tactacacga tggccgtgcc ccaccgctgg aacggatccc tcgtggtgca cgcccacggc
    20401 ggccccgacc tcggcgacgc ctcggacccg gctcgcagca ccgaggacct ggaacgctgg
    20461 gcggtgatgg tcgaccaggg atacgcctgg gccgcctcct cctaccggcg cggcggctac
    20521 ggggcccgca tggcggccgc cgacaccgag aacgtgcgcc gcctgttcac cgaccggttc
    20581 ggccggcccg aacacaccta cctgcacggc cagtcctggg gcgggaacgt cgccgccaag
    20641 gccgccgaga cctacggccg gcgcccgggc gcctatgacg gggtgctgct gaccaacggc
    20701 gtgctcggcg gcggttcgcg cggctacgac taccgcgtgg acctgcgggt ggtctaccag
    20761 tactactgcc acaaccaccc gcgcccgagc gagccgcagt acccgctgtg gcagggcctg
    20821 cgccccggct ccaccatgac caccgcgggc ctgcgcgccc ggctccagga gtgcacgggc
    20881 tacgcctccg aaccggccga ccggacccgg gcgcagcagc gcaacctcga cgacatcctc
    20941 gccgtcaccg gcatccccga acgcaccctg gaatcccatc tgcggttcgc caccttcacg
    21001 ttccgggaca tcgtgaccaa ccggctcggc gggcggaacc cctggagcaa ccggggggtg
    21061 cgctactcgg gttcgcacga cgacaaggcg ctgaacgcgg gcgtcgagcg cttctcggcc
    21121 gaccccac
//
