LOCUS       NZ_BMVQ01000004         7948 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces anthocyanicus strain JCM 4739 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVQ01000004
VERSION     NZ_BMVQ01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces anthocyanicus
  ORGANISM  Streptomyces anthocyanicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceoruber group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 618389)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:14:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,934
            CDSs (total)                      :: 7,858
            Genes (coding)                    :: 7,681
            CDSs (with protein)               :: 7,681
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 73 of 177
            Pseudo Genes (incomplete)         :: 130 of 177
            Pseudo Genes (internal stop)      :: 16 of 177
            Pseudo Genes (multiple problems)  :: 37 of 177
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:48:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7948
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVQ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..7948
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..7948
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7948
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2003:2948](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(2004..2948)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    complement(82..96)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    110..127
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.92"
                     /tool="antismash"
     gene            162..983
                     /locus_tag="IE283_RS12850"
                     /old_locus_tag="GCM10010348_26060"
     CDS             162..983
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="IE283_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_26060"
                     /product="ATP-binding protein"
                     /protein_id="WP_016327671.1"
                     /transl_table=11
                     /translation="MSATSAPAPQHGMTWLGAIVEDGFTETLQDGLSRSRFGRARQTTG
                     TAHPGLPADGRDPAAGPVRTDRDGRDDHVWAERRRLAREVHDELGTALSTAAHHIELHA
                     AETGGTPHLDAARHSLREAMAVARRLTGELQAQTVLPPLAQAVGEFAATTRPPGTEVRI
                     RTTGDERLLSDVCRRELFLAVREALHNAFHHAHADRVTVTLRFTRRWAHAGIVDDGVGF
                     DADAVLVPGHRAPGLRSMTDRIEDVGGRLLIVSGPAGGTHIDVHLPLRPRK"
     gene            complement(1034..1888)
                     /gene="scbC"
                     /locus_tag="IE283_RS12855"
                     /old_locus_tag="GCM10010348_26070"
     CDS             complement(1034..1888)
                     /codon_start=1
                     /gene="scbC"
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030780.1"
                     /locus_tag="IE283_RS12855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_26070"
                     /product="butenolide phosphate reductase ScbC"
                     /protein_id="WP_011030780.1"
                     /transl_table=11
                     /translation="MILVTGVTGVVGRQVAHLLARTGPVRVLARRPERVTVTGPNVEVC
                     AGEYADRPGLDRALNGVRAAFLVTNSATEPDDERFAAAAREAGVRHLVKLSMLAVGEPG
                     ADDFITRRQRENERAVRESGLDWTFLRARTFMSNTLSWAPAIRSDGVVRALYGTSPVAC
                     VDPRDIAEVAVRALTRPGHEGRAYALSGPEAITARQQTARLSEVLGRSLRFEELGLEAA
                     REQLLRKYPRPVADAFLESAERQRAGAKAQVVPTVREVTGRPARPFRIWAADHAEAFGR
                     SQG"
     misc_feature    complement(1925..1940)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            complement(2004..2948)
                     /gene="scbA"
                     /locus_tag="IE283_RS12860"
                     /old_locus_tag="GCM10010348_26080"
     CDS             complement(2004..2948)
                     /codon_start=1
                     /gene="scbA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972659.1"
                     /locus_tag="IE283_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_26080"
                     /product="gamma-butyrolactone biosynthesis protein ScbA"
                     /protein_id="WP_003972659.1"
                     /sec_met_domain="AfsA (E-value: 1.3e-26, bitscore: 87.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEAVVLINSASDANSIEQTALPVPMALVHRTRVQDAFPVSWIPK
                     GGDRFSVTAVLPHDHPFFAPVHGDRHDPLLIAETLRQAAMLVFHAGYGVPVGYHFLMAT
                     LDYTCHLDHLGVSGEVAELEVEVACSQLKFRGGQPVQGQVDWAVRRAGRLAATGTATTR
                     FTSPQVYRRMRGDFATPTASVPGTAPVPAARAGRTRDEDVVLSASSQQDTWRLRVDTSH
                     PTLFQRPNDHVPGMLLLEAARQAACLVTGPAPFVPSIGGTRFVRYAEFDSPCWIQATVR
                     PGPAAGLTTVRVTGHQDGSLVFLTTLSGPAFSG"
     misc_feature    complement(3004..3024)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    complement(3021..3034)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.2"
                     /tool="antismash"
     gene            3066..3713
                     /locus_tag="IE283_RS12865"
                     /old_locus_tag="GCM10010348_26090"
     CDS             3066..3713
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972660.1"
                     /locus_tag="IE283_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_26090"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_003972660.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQTILDAAAQVFEKQGYQAATITEILKVAGVTKGA
                     LYFHFQSKEELALGVFDAQEPPQAVPEQPLRLQELIDMGMLFCHRLRTNVVARAGVRLS
                     MDQQAHGLDRRGPFRRWHETLLKLLNQAKENGELLPHVVTTDSADLYVGTFAGIQVVSQ
                     TVSDYQDLEHRYALLQKHILPAIAVPSVLAALDLSEERGARLAAELAPTGKD"
     gene            complement(3829..4617)
                     /gene="scbB"
                     /locus_tag="IE283_RS12870"
                     /old_locus_tag="GCM10010348_26100"
     CDS             complement(3829..4617)
                     /NRPS_PKS="Domain: PKS_KR (15-194). E-value: 3.1e-11.
                     Score: 35.4. Matches aSDomain:
                     nrpspksdomains_IE283_RS12870_PKS_KR.1"
                     /codon_start=1
                     /gene="scbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030779.1"
                     /locus_tag="IE283_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_26100"
                     /product="A-factor type gamma-butyrolactone 6-reductase
                     ScbB"
                     /protein_id="WP_011030779.1"
                     /sec_met_domain="adh_short (E-value: 3.1e-30, bitscore:
                     100.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAHGTRYGRPLEGKTALVTGGSRGIGRGIALRLAADGALVAVHY
                     GSSEAAARETVETIRSSGGQALAIRAELGVVGDAAALYAAFDAGMGEFGVPPEFDILVN
                     NAGVSGSGRITEVTEEVFDRLVAVNVRAPLFLVQHGLKRLRDGGRIINISSAATRRAFP
                     ESIGYAMTKGAVDTLTLALARQLGERGITVNAVAPGFVETDMNARRRQTPEAAAALAAY
                     SVFNRIGRPDDIADVVAFLASDDSRWITGQYVDATGGTIL"
     aSDomain        complement(4036..4572)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS12870_PKS_KR.1"
                     /evalue="3.10E-11"
                     /label="IE283_RS12870_PKS_KR.1"
                     /locus_tag="IE283_RS12870"
                     /protein_end="194"
                     /protein_start="15"
                     /score="35.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGGSRGIGRGIALRLAADGALVAVHYGSSEAAARETVETIR
                     SSGGQALAIRAELGVVGDAAALYAAFDAGMGEFGVPPEFDILVNNAGVSGSGRITEVTE
                     EVFDRLVAVNVRAPLFLVQHGLKRLRDGGRIINISSAATRRAFPESIGYAMTKGAVDTL
                     TLALARQLGERGITVN"
     CDS_motif       complement(4501..4566)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS12870_0001"
                     /evalue="4.70E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE283_RS12870"
                     /protein_end="39"
                     /protein_start="17"
                     /score="12.9"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRGIALRLAADGA"
     gene            complement(4780..7155)
                     /locus_tag="IE283_RS39705"
                     /old_locus_tag="GCM10010348_26110"
     CDS             complement(4780..7155)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994025.1"
                     /locus_tag="IE283_RS39705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_26110"
                     /product="SWIM zinc finger family protein"
                     /protein_id="WP_246549973.1"
                     /transl_table=11
                     /translation="MTPRPADEARRALREARERGEGTGADAHRGPTPTPMSPPPPPPPS
                     PAPSEAESARGQDGRQEGDQDGMPPEHDRPRPGDVARAALRSALTARRTGAHSPADLPD
                     APDAPGAADTLETGPGDSRKPGGRGEAADPGETAFRPDAMTGWTGSTDPTASTDPTAST
                     DPAVPTGPVAPVDPTGPAAAPADPTGPTDPTGSPVPLGPPVAAVPEEESLPGSGDAGGS
                     RPADVAREALRAARRQAKAEAAAEGVSAQGAAPARWSSRPAARQRPAGGPGTADARARA
                     VRDFAAGAFRLPPEADQAEEPLPAGEQAGTSSAQGGATAHAEPAPSPGTAHAEPASSPG
                     ADTGQSVSAVRGRAVSSAPPAKARAPRSMAAPDRDGDLRRTFPALPPREAAAEGFAATW
                     WGNAWVTALEEGALDAARLERGRGYAEHGHVDAITVTPGLVLAYVRGSRSRPYRVQVRL
                     RTLGDSDWDRFLDAAVERPGHIAALLDGELPHSLADLADRGVPLLPGPGDLAPRCSCPD
                     SGHPCKHAAALCYQTARLLDADPFVLLLLRGRGERALLDALSRRNAAREARAAQDRGPG
                     PLPGVRAGAALTPRALPPLPAPLPAPPHPEQPPAYPAAPGGPDPFALDQLATDAAARAH
                     ALLTTGRDPVGGLTLWQDAVRLAAARPGSGLTAGTRALYASLASAAGRDTAELARAVAA
                     WRQGGLAGLDVLEEPWDPPAGRFDRARPLLLAADLPAFRPWRNRLSHPRGHVQLRLGRT
                     GLWYAYESEPGREDWWPRGTPDLDPVGALTGLGGPGDL"
     misc_feature    7232..7246
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
ORIGIN
        1 ctcatgtccg aacagctcga caccgccgtc gaaacagacg gcaagggcga cctcgccacg
       61 ttgttcaacg gtggggacac cttctcccat tgaaaaccgg cgaggaggtt tgttaatccc
      121 atgttccctg gaccgacctg tttcgagatc gaggaggaca gttgagcgcc acttctgccc
      181 ccgcacccca gcacggcatg acctggctgg gagccatcgt ggaggacggc ttcacggaga
      241 cgttgcagga cgggctcagc cgctcccgct tcggccgcgc ccggcagacc accggcacgg
      301 cacatccagg gctccccgca gacggtcgtg acccagcggc cggccccgtc cggacggacc
      361 gcgacggccg ggacgaccac gtctgggccg agcgccgcag actggcgcgc gaggtccacg
      421 acgaactggg cacggctctg tccacggccg cccaccacat cgagctgcac gccgccgaga
      481 ccggcgggac cccccatctc gacgccgccc ggcactcact gcgtgaggcg atggccgtcg
      541 cccgcaggct gaccggcgag ctccaggcgc agaccgtact gccgccgctg gcccaggcgg
      601 tgggggagtt cgccgccacc acccgtcccc cggggaccga ggtccgcatc aggaccaccg
      661 gagacgaacg gctcctgtcg gacgtctgcc gccgtgaact gttcctcgcc gtacgcgagg
      721 ccctgcacaa cgccttccac cacgcacacg ccgatcgggt gaccgtgacc ctgcgcttca
      781 cccgccgctg ggcacacgcc ggcatcgtcg acgacggcgt cgggttcgac gccgacgcgg
      841 tactcgttcc cggccaccgg gcaccgggtc tgcgctcgat gaccgaccgc atcgaggacg
      901 tcggcgggcg gctcctgata gtgagcggcc ccgccggcgg cacgcacatc gacgtccatc
      961 tcccactgcg cccccggaag tgagcaccgc accgcggacg tgacgccatg ggagggccac
     1021 gtccgcggac ggatcacccc tggcttcggc cgaaggcttc cgcgtggtcc gccgcccaga
     1081 tgcggaacgg cctggcgggc cggcccgtca cttcccgcac ggtcggcacg acctgcgcct
     1141 tggcccccgc ccgctgccgc tcggcgctct ccaggaacgc gtcggcgacg ggcctcggat
     1201 acttccggag cagctgctcg cgcgccgcct ccagccccag ctcctcgaaa cgcagtgacc
     1261 gccccagcac ctcggagagc cgcgccgtct gctgcctggc ggtgatcgcc tcgggcccgg
     1321 acagcgcgta cgcccgtccc tcgtggccgg gccgggtcag tgccctgacc gccacttccg
     1381 cgatgtcgcg cggatcgacg caggcaaccg gggacgtgcc gtacagcgcg cggaccacgc
     1441 cgtcggaccg gatggcgggc gcccaggaca gcgtgttgga catgaaggtc ctggcccgca
     1501 ggaaggtcca gtcgagcccg gactcgcgta cggcccgctc gttctcgcgc tgccgccgcg
     1561 tgatgaagtc gtccgcgccc ggttccccca ccgcgagcat ggacagcttc accaggtgcc
     1621 ggacgccggc ctcgcgcgcc gccgccgcga aacgctcgtc gtccggctcg gtggcactgt
     1681 tcgtgacgag gaacgccgcc cgcaccccgt tgagggcccg gtccaggccc gggcggtcgg
     1741 cgtactcgcc cgcgcagacc tcgacgttcg ggccggtgac ggtcacccgt tccggccgcc
     1801 gggcgaggac tctgacggga ccggtccggg ccagcaggtg ggcgacctga cggccgacca
     1861 caccggtcac gccggtcaca agaatcactc ggggctcctc tcgggcagcg aggcaggggc
     1921 gcctccgaac atacatatga ggggaagggc aggacctggc cccggggcgc gaaccggcga
     1981 tgttcgcgcc ccggggccgg tgctcagccg gagaacgcgg ggccggacag cgtggtgagg
     2041 aagacgaggc tgccgtcctg atgcccggtg acccgcacgg tggtcagccc cgccgccgga
     2101 cccggccgga ccgtcgcctg gatccagcac gggctgtcga actccgcgta ccggacgaac
     2161 cgggtgccgc cgatcgacgg cacgaagggc gccggaccgg tcacgaggca cgccgcctgc
     2221 cgtgccgcct cgagcagcag catgcccggt acgtggtcgt tggggcgctg gaagagggtc
     2281 gggtgactgg tgtccacccg cagtcgccac gtgtcctgct gcgaactcgc cgacaggacc
     2341 acgtcctcgt cgcgggtgcg accggcgcgc gccgcgggca cgggcgcggt cccgggcacc
     2401 gatgcggtgg gagtcgcgaa gtcgccgcgc atccgccggt agacttgagg actggtgaag
     2461 cgcgtcgtgg cagtccccgt ggcagcgagc cgtccggcgc ggcgcacggc ccagtccacc
     2521 tgtccctgta cgggctgccc gccgcggaac ttcagctggg aacaggccac ttccacctcc
     2581 agctccgcga cctcgcccga cacgccgagg tggtcgaggt ggcaggtgta gtccagcgtg
     2641 gccatcagga agtggtagcc caccggcacg ccgtagccgg cgtggaagac gagcatcgcc
     2701 gcctgacgca gggtctcggc gatcagcagc ggatcgtgtc ggtccccgtg gaccggtgcg
     2761 aagaacgggt ggtcgtgggg caggacggcg gtgaccgaga accggtcacc gcccttcggt
     2821 atccagctga ccgggaacgc gtcctgcacc ctggtccggt ggacaagcgc catcggaacc
     2881 ggcaatgcgg tttgttcgat cgagttggca tcggacgcag aattgatcaa aactactgct
     2941 tcgggcatgg gtccccccca ggaatcatgt gatgccgagc tgttctgtat gcgcgaacgt
     3001 taagatacag actgagcggt tttttttcta tccttcccgg gggagacatg aacaaggagg
     3061 caggcatggc caagcaggac cgggcgatcc gcacgcggca gacgatcctg gacgccgcgg
     3121 cgcaggtctt cgagaagcag ggctaccaag ctgccacgat cacggagatc ctcaaggtgg
     3181 ccggggtgac caagggagcc ctctacttcc acttccagtc caaggaagaa ctggcgctgg
     3241 gcgtcttcga cgcccaggaa ccaccacagg ccgttccgga gcaacccctc cggctgcaag
     3301 aactcatcga catgggcatg ttgttctgtc accgcttgcg cacgaacgtc gtggcccggg
     3361 ccggcgtgcg cctctccatg gaccagcagg cgcacggtct cgatcgccga ggacccttcc
     3421 gtcgctggca cgagacactc ctgaagctgc tgaaccaggc caaggaaaac ggtgagttgc
     3481 tgccccatgt ggtcaccacc gactcggccg atctctacgt gggcacgttc gccgggatac
     3541 aggtcgtgtc ccagacggtc agcgactacc aggacctcga acaccgctac gcgctgctgc
     3601 agaagcacat cctgcccgcc atcgcggttc cctccgtgct ggccgctctc gatctctccg
     3661 aggagcgcgg agcacgcctc gcggccgaac tggcaccgac cgggaaggac tgaccgccga
     3721 agcgcccgca ccggataccg acccgccgtg cccgagcggc cgaccggggc cgcccacggg
     3781 cccggcggcg ggcccgtagg tctgccctgc gtaccgaagc gtggcgggtc agagaatcgt
     3841 tccgcctgtg gcgtcgacgt actggccggt gatccaccgt gagtcgtcgg aggccagaaa
     3901 ggccaccacg tcggcgatgt cgtcgggtct gccgatgcgg ttgaacacgg agtaggcggc
     3961 cagtgccgcg gccgcctcgg gggtctgccg ccgccgtgcg ttcatgtccg tctccacgaa
     4021 acccggcgcc accgcgttga ccgtgatccc ccgttccccc agttgcctgg ccagggcgag
     4081 cgtgagcgtg tccaccgcac ccttggtcat cgcgtatccg atggactcgg ggaacgcgcg
     4141 ccgggtcgcg gcagacgaga tgttgatgat ccgcccgccg tcgcgcagtc gtttcagtcc
     4201 gtgctggacc aggaacagcg gtgcccggac gttgacggcg accagtcggt cgaagacctc
     4261 ctcggtgact tccgtgatcc gtcccgagcc gctgacgccc gcgttgttca ccaggatgtc
     4321 gaactcgggc ggcactccga actcgcccat ccccgcgtcg aacgccgcgt agagcgcggc
     4381 cgcgtcaccc acgacgccga gttcggcccg gatggccaac gcctgtccgc cgctgctccg
     4441 gatggtctcg acggtctctc gcgccgccgc ctcgctgctg ccgtagtgga ctgccacgag
     4501 cgccccgtcc gcggccagcc gcagggcgat accgcgtccg atgccccggc ttcccccggt
     4561 caccagggcg gtcttgccct ccagcggtct tccatacctc gtcccatgtg cacgcatatc
     4621 agcccccgcc gtgcgtgagc gacccatggc ggccgctcgg ccgttcgaat cgacggtcac
     4681 agcctacctg tgaccgcgtc agacggggcc ggagtggccc ggttggacgg ctggggccag
     4741 atcgggcggc gcgcacgggg aaccggcgcc ggtcaggggt cagaggtcgc cgggaccgcc
     4801 caggccggtc agggcaccga ccggatcgag gtcgggcgtg ccacgcggcc accagtcctc
     4861 gcggcccggc tccgactcgt acgcgtacca gagcccggtc cggccgagtc tgagctggac
     4921 gtggccgcgc gggtggctga ggcggttgcg ccaggggcgg aaggcgggga ggtcggcggc
     4981 gagcagcagg gggcgggcgc ggtcgaaacg gccggccggc gggtcccagg gctcctccag
     5041 gacgtcgaga cccgccaacc cgccctgccg ccaggcggcg acggcccgcg ccagctccgc
     5101 cgtgtcgcgt ccggcggccg aggcgagcga cgcgtagagc gcgcgggtac ccgcggtgag
     5161 gccggaaccg gggcgcgcgg cggcgagccg gacggcgtcc tgccacagcg tcagtccgcc
     5221 gaccgggtcg cgcccggtgg tgaggagggc gtgggcgcgg gcggccgcgt cggtggccag
     5281 ctggtccagc gcgaaggggt cggggccgcc cggggcggcc gggtaggccg gcggctgttc
     5341 ggggtgcggc ggcgcgggca acggcgccgg gaggggcggc agggcgcgcg gggtcagcgc
     5401 cgcgccggcc cggacgccgg gcagcggtcc ggggccgcgg tcctgggccg cgcgtgcctc
     5461 gcgggccgcg ttccgccggg acagggcgtc aagcagcgcg cgttcgcccc ggccgcggag
     5521 cagcagcagg acgaaggggt cggcgtcgag cagacgtgcc gtctggtagc agagggcggc
     5581 ggcgtgcttg caggggtgcc cggagtcggg gcagctgcac cgcggggcca ggtcgccggg
     5641 tccgggcagc agcgggacgc cgcggtcggc caggtcggcc agggagtggg gaagttcccc
     5701 gtcgagcagc gccgcgatgt gcccggggcg ttcgacggcg gcgtcgagga accggtccca
     5761 gtcggagtcg ccgagcgtac gcagccgcac ctgcacgcgg tacggccggg agcggctgcc
     5821 ccgcacgtag gcgaggacca gcccgggcgt cacggtgatg gcgtcgacgt gcccgtgctc
     5881 ggcgtatccg cgcccgcgtt ccagccgggc ggcgtccagg gcgccttcct ccagcgcggt
     5941 cacccacgcg ttcccccacc aggtggcggc gaagccctcc gccgcggcct cccggggcgg
     6001 cagcgcggga aaggtgcgcc ggaggtcgcc atcacggtcc ggggcggcca tcgagcgggg
     6061 cgcgcgggcc ttcgcgggcg gtgcggagga gacggcccgg ccacgcaccg ccgagacgga
     6121 ctgccccgtg tccgcgccgg gcgacgaggc gggctccgcg tgtgccgtgc cgggcgacgg
     6181 ggcgggctcc gcgtgtgccg tcgccccgcc ctgggcggag gacgtaccgg cctgctcccc
     6241 ggcgggcagg ggctcctcgg cctggtccgc ctccgggggc agccggaagg cgccggcggc
     6301 gaagtcccgc acggcgcggg cgcgcgcgtc ggcggtgccc ggaccgcccg ccggccgctg
     6361 acgagcggcc gggcgggacg accaccgcgc gggcgcggcg ccctgggccg agacgccctc
     6421 ggccgccgcc tccgccttcg cctgccgacg agccgcccgc aacgcctcac gcgccacatc
     6481 cgccggtcgg ctgccgcccg cgtcaccgga gccggggagg gactcctcct cgggaacggc
     6541 cgcgacgggc gggccgagcg ggacgggcga gccggtcggg tctgtgggac cggtcgggtc
     6601 agcgggggcg gccgcgggac cggtcgggtc aaccggggcg accgggccgg tggggacggc
     6661 cgggtccgtg gaggcggtcg ggtcggtgga ggcggtcggg tcggtggagc ccgtccaccc
     6721 ggtcatggcg tcgggccgga acgccgtctc gcccggatcc gccgcctctc cacgccctcc
     6781 cggcttccgg gagtcacccg gaccagtctc caaggtgtca gcggcgcccg gggcgtcagg
     6841 tgcgtcggga aggtccgcgg gactgtgcgc ccccgtccgc cgcgcggtca gcgcactgcg
     6901 cagcgcggcc cgggcgacgt ctccggggcg cggacggtcg tgctccggcg gcatcccgtc
     6961 ctggtcccct tcctggcgcc cgtcctggcc ccgtgccgac tccgcctccg acggtgccgg
     7021 agacggtggc ggtggcggtg gcggagacat cggcgtcggc gtcggcccac ggtgcgcgtc
     7081 cgcgcccgta ccctcgccgc gctcgcgtgc ctcccgcagg gcgcggcggg cctcgtccgc
     7141 gggccggggg gtcacgagtg cctccgcagg gacaccaggt cggacagttc acgcgccgtc
     7201 agttcggtga gggccgactc tccggagccg aggatcgcgt cggccagggc ccgcttggac
     7261 tggagcatct cggcgatgcg gtcctcgacc gtgccctcgg tgatgagccg gtggacctgg
     7321 accggctggg tctggccgat gcggtaggcg cggtcggtgg cctgctcctc cacggccggg
     7381 ttccaccagc ggtcgaagtg cacgacgtgg ccggcgcggg tgaggttcag gccggtgccc
     7441 gcggccttca gggacaggac gagcacggga gtcgccccgc tctggaaacg gtccaccatc
     7501 cgctcgcgct ccggcaccgg cgtaccgccg tgcaggaggt cgaccgggac cgcgcgggcg
     7561 gccaggtggg aggtgatgag gcgggccatg ccgacgtact gcgtgaagac cagcaccgag
     7621 ccgtcctccg cgagcaccgt gtccagcagc tcgtccagca gggcgagctt gcccgagcgg
     7681 gcggtcatcc ggtcggtccc gcccggcggg tgctcctcct tcaggaacag cgcggggtgg
     7741 tcgcagatct gcttgagcga ggtcagcagc ttgaggacga ggccgcggcg gccgatgccc
     7801 tcggcctcct cgatggcgag catcgactcg cgcaccaccg cctcgtacag cgcggcctgc
     7861 tcgcgggtga gcgggacggg gtggtccgtc tcggtcttcg gcggcagctc ggggacgatg
     7921 cccgggtcgg acttcctgcg gcgcagga
//
