LOCUS       NZ_BMVQ01000001        24559 bp    DNA     linear   CON 11-FEB-2024
DEFINITION  Streptomyces anthocyanicus strain JCM 4739 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVQ01000001
VERSION     NZ_BMVQ01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces anthocyanicus
  ORGANISM  Streptomyces anthocyanicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceoruber group.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1401614)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:14:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,934
            CDSs (total)                      :: 7,858
            Genes (coding)                    :: 7,681
            CDSs (with protein)               :: 7,681
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 177
            CDSs (without protein)            :: 177
            Pseudo Genes (ambiguous residues) :: 0 of 177
            Pseudo Genes (frameshifted)       :: 73 of 177
            Pseudo Genes (incomplete)         :: 130 of 177
            Pseudo Genes (internal stop)      :: 16 of 177
            Pseudo Genes (multiple problems)  :: 37 of 177
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:48:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 185911
            Orig. end                         :: 210470
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVQ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24559
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24559
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24559
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14559](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14559
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    262..276
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     gene            343..1344
                     /locus_tag="IE283_RS00835"
                     /old_locus_tag="GCM10010348_01800"
     CDS             343..1344
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026966.1"
                     /locus_tag="IE283_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01800"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_011026966.1"
                     /transl_table=11
                     /translation="MYSKDGENYFIVDAHVALWDARRENQRNIHGKQFIDCFYDYHRNL
                     SPASELWPYEDFLYQGGERLMKDLFTDGYVDHAIFQPAHLGAFYNTGFGQTEEAFALTR
                     KHPGMLTYNHCFDPRFEEAGLKQLREDAARFGLKGVKLYTAEWKGDSRGYKLSDPWTYR
                     YLDACRELGIKNIHVHKGPTIRPLDRDAFDVADVDAAASDFTDLNFVVEHCGLPRLEDF
                     CWIATQEPNVHAGLAVAIPFMHTRPRYFAQIIGELLYWLDEDRIQFSSDYALWTPRWIV
                     EQFVDFRIPDDMTGEYPQLTVAQKKKILGLNAAAMYDIEVPAGLGLAEPAVV"
     misc_feature    complement(361..372)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.32"
                     /tool="antismash"
     gene            1346..2155
                     /locus_tag="IE283_RS00840"
                     /old_locus_tag="GCM10010348_01810"
     CDS             1346..2155
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026967.1"
                     /locus_tag="IE283_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01810"
                     /product="iron-sulfur cluster assembly protein"
                     /protein_id="WP_011026967.1"
                     /transl_table=11
                     /translation="MWAAQLEVAARAALDTVYDPELDEPVTDLGFVRSLTAEDGRVTVH
                     LRLPTSFCSPNFAYLMASDAKDALSALPGAREVTVLLDDHHDSDLINRGLAADAGYRGT
                     FGHEAEQDLEELRGIFRRKAHTAAMERALTALLRARPDLAEEQLGDVVLGDLPDTSATR
                     ALLRRRAALGLGTAPADPALVDDDGRPCPRGEVPLRLRFARSVRISIDGNAHFCRGLLR
                     TRYPQSAADQSARPEEFPAGGEPVGAGETVPAGELFRLSAPAKENVS"
     gene            2152..3177
                     /locus_tag="IE283_RS00845"
                     /old_locus_tag="GCM10010348_01820"
     CDS             2152..3177
                     /NRPS_PKS="Domain: PKS_ER (119-244). E-value: 4.6e-09.
                     Score: 27.7. Matches aSDomain:
                     nrpspksdomains_IE283_RS00845_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978606.1"
                     /locus_tag="IE283_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01820"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_003978606.1"
                     /sec_met_domain="ADH_N (E-value: 1.2e-33, bitscore: 111.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7.4e-19, bitscore:
                     64.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVQVVGYGKNLEMAEVPAPEVTGPYDVIVRIGGAGVCRTDLHI
                     LEGQWAEKSGVELPYTIGHENAGWVHAVGSAVTNVSEGDKVIVHPLITCGLCRACRAGD
                     DVHCENNRFPGIDTAGGYAEYLKTSARSVVRLDDSLEPADVAALADAGLTAYHAAAKAA
                     RRLRPGDRCVVIGAGGLGHIGIQVLGALTAAEIVVVDRNPDAVDLAVSVGADHGVLADG
                     GHVDRVRELTGGHGAEAVIDFVGEGGSTGDGIGMLRRAGDYHVVGYGENIDVPTIDVIS
                     AEINFIGNLVGSYNDLCELMVLAARGRVRLHTAKYSLDRFQDALDDLDGGRIRGRAILV
                     P"
     aSDomain        2509..2883
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS00845_PKS_ER.1"
                     /evalue="4.60E-09"
                     /label="IE283_RS00845_PKS_ER.1"
                     /locus_tag="IE283_RS00845"
                     /protein_end="244"
                     /protein_start="119"
                     /score="27.7"
                     /tool="antismash"
                     /translation="GGYAEYLKTSARSVVRLDDSLEPADVAALADAGLTAYHAAAKAAR
                     RLRPGDRCVVIGAGGLGHIGIQVLGALTAAEIVVVDRNPDAVDLAVSVGADHGVLADGG
                     HVDRVRELTGGHGAEAVIDFV"
     misc_feature    complement(3230..3243)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            3230..3559
                     /locus_tag="IE283_RS00850"
                     /old_locus_tag="GCM10010348_01830"
     CDS             3230..3559
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978605.1"
                     /locus_tag="IE283_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01830"
                     /product="putative quinol monooxygenase"
                     /protein_id="WP_003978605.1"
                     /transl_table=11
                     /translation="MIFITAKFRVLPEHADQWPQVVEDFTRATRAEPGCLWFDWSRSLD
                     DPTEYVLVEAFRDDEAGAAHVGSAHFKAAQQTLPPHLATTPRIVNANVPQDDWSLLGEM
                     AVDAG"
     gene            complement(3639..4166)
                     /locus_tag="IE283_RS00855"
                     /old_locus_tag="GCM10010348_01840"
     CDS             complement(3639..4166)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449887.1"
                     /locus_tag="IE283_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01840"
                     /product="sugar O-acetyltransferase"
                     /protein_id="WP_011026968.1"
                     /transl_table=11
                     /translation="MYVHTPEFARHAERIVEVTDATSRLNVLPFSDSAGRSELLSVVFG
                     GPLPESVTIYPPFFTEYGLNTTFGENVFVNQGCTFMDKGGIRIGNRVMIAPKASLVTGG
                     HPLPLAERRAHLSFAPIVVEDDVWIGTAAVITQGVTIGAGAVVAAGAVVTRDVPAGTVV
                     AGVPARVIKQIG"
     misc_feature    complement(4155..4169)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            4280..5215
                     /locus_tag="IE283_RS00860"
                     /old_locus_tag="GCM10010348_01850"
     CDS             4280..5215
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026969.1"
                     /locus_tag="IE283_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01850"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_011026969.1"
                     /transl_table=11
                     /translation="MDVEALRTFVVVAGVGQFQAAADELGISQQAVSKRIAALERHVAV
                     TLVVRSSRGSRLSLDGQVFLPHAKKVLTAVEQAERAVNPGSRPLRVDVLNRRISPAQAV
                     YRFYRSRPETDLDAVTLDKENAAQAAQAVLEGVVDASFRALPADRVPTGITAERLLDEP
                     LELLVGPGHPLADAPRISPVDLAGHRIWIPGIRPGTEWAAFYQALSEAFGLSIDALGPN
                     FGDEALMDALADSASLATLVGRGDRYLWPRTHDLRRIPLHDPTPFYPHLLLFRTGDRHP
                     VLTALRDHLRTTAPRTPHDAWTPDWTVTVH"
     gene            complement(5239..6354)
                     /locus_tag="IE283_RS00865"
                     /old_locus_tag="GCM10010348_01860"
     CDS             complement(5239..6354)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026970.1"
                     /locus_tag="IE283_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01860"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_011026970.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.2e-17, bitscore:
                     61.0, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 6.8e-11,
                     bitscore: 38.5, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTPGSALADLARSGRPIGVGVIGLGAHGSWAERSHLPALRAVGG
                     FELRALSTSSKQSAERSGHKHGVRRAFGTAAELAACDEVDLVVVAVKVPHHRELVRTVL
                     NAGKSVLCEWPLGNGLAEAEDMARLARAHAVPTVVGLQARSHPAFAYTRHLVADGYVGE
                     VLSTTVVGSGGAWGATVGPADHHVLDAANGATLLTVPFGHALDGVASVLGEPEELRIQA
                     ASRRTSAVDTETGRPVPMTAADQVVASGRLPGGAVATFHYRGGMSRGTNFRWEINGTEG
                     DLVLTAPVGHPQLSPLTLEGGRGTSTALAPLTVPEAYARVARLEPRADAPAYAVAHAYQ
                     RFLDDLREGTAHVPDFAHGVVRHRSIEQYLP"
     misc_feature    complement(6415..6430)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            6421..6873
                     /locus_tag="IE283_RS00870"
                     /old_locus_tag="GCM10010348_01870"
     CDS             6421..6873
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978601.1"
                     /locus_tag="IE283_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01870"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_030862236.1"
                     /transl_table=11
                     /translation="MSTRGRAPDPQEGTSEAALDPVGLWSAFKRAHEVVRTRVIADAAE
                     AAGLSEPDLTILADLNKAGGALRQSELAASLGWDRTRVSHQLTRMSKRELVTRRRANGV
                     IVALTDAGHQAITAVYPGLDAAVRRHFTDKLSTQEVETLAAVLGRL"
     gene            6974..7765
                     /locus_tag="IE283_RS00875"
                     /old_locus_tag="GCM10010348_01880"
     CDS             6974..7765
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978600.1"
                     /locus_tag="IE283_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01880"
                     /product="VOC family protein"
                     /protein_id="WP_030862240.1"
                     /transl_table=11
                     /translation="MITNDFAPGSPCWLDLGSPDVAGTVAFYGGVFGWTYEAMGEDAEG
                     GMFRKDGKIVAGLGRLTEEGARSAWMIYYSVTDADATTQAVQRAGGTVRVAPTDLDDWG
                     RMAQYSDPSGGQFAVWQPGRTRGVELVDQPGTLCWTELYTSDAAAAKEFYGGVLGWRFG
                     DMAVPGGEGTYSLITPSGLSEDRMHGGLMQLDERDLTLTGGRAYWHPVFAVTDCDAAVS
                     AVTAHGGSVQMGPADAEGVGRLAVCLDPSKADFVVLAPASG"
     gene            complement(7807..8673)
                     /locus_tag="IE283_RS00880"
                     /old_locus_tag="GCM10010348_01890"
     CDS             complement(7807..8673)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325042.1"
                     /locus_tag="IE283_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01890"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_051815035.1"
                     /transl_table=11
                     /translation="MSEIRQMTYQPPGRGAASVETMTFGRLRELNDGGTQRADFHVLAV
                     VDAGRGSVTVDFRLHPLQDRSAVWIPPGAVHRWDDVAEVEGDLVLFVPTAPVTHATREL
                     VASPDPAAHWIVPAADWPFVDAARGHLRLEASAPPSDSSTELPAILLSALIARLHPPHA
                     EARLAHPVFRLFRSSVEANFRQHHDAGYYARTLGYAPRTLSRAVRQATGRTAKAYVVER
                     LVLEAKRLLAHERLTAARCAGVLGFPDASNFSVFFHKATGERPGAWQAAATGPGVPTAS
                     TPPEPVT"
     gene            8786..9562
                     /locus_tag="IE283_RS00885"
                     /old_locus_tag="GCM10010348_01900"
     CDS             8786..9562
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (19-244). E-value:
                     7.8e-21. Score: 66.7. Matches aSDomain:
                     nrpspksdomains_IE283_RS00885_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026973.1"
                     /locus_tag="IE283_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01900"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_030862246.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-14, bitscore: 50.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 5.6e-07, bitscore:
                     26.3, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.2e-18, bitscore:
                     64.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTQHTLVPVYDHRTGTGPTLVFLHYWGGSARTWDLVVDRLPGR
                     AVAAVDFRGWGRSRALPGPYTLGRFADDTLAVLADAGITDYVLVGHSMGGKVAQLVAAT
                     RPAGLRAIVLVGSGPAKPAARVTPEYREALSHAYDSAESVAGARDHVLTATELPAALKA
                     RIVTDSRNVTDAARIEWPLRGIAQDITEHTRRIDVPALVVAGEHDQVEPAGVLRDNLVP
                     YLARADFVVVPRTGHLIPLEAPADLADAVTAFATAV"
     aSDomain        8843..9517
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE283_RS00885_Abhydrolase_1.1"
                     /evalue="7.80E-21"
                     /label="IE283_RS00885_Abhydrolase_1.1"
                     /locus_tag="IE283_RS00885"
                     /protein_end="244"
                     /protein_start="19"
                     /score="66.7"
                     /tool="antismash"
                     /translation="PTLVFLHYWGGSARTWDLVVDRLPGRAVAAVDFRGWGRSRALPGP
                     YTLGRFADDTLAVLADAGITDYVLVGHSMGGKVAQLVAATRPAGLRAIVLVGSGPAKPA
                     ARVTPEYREALSHAYDSAESVAGARDHVLTATELPAALKARIVTDSRNVTDAARIEWPL
                     RGIAQDITEHTRRIDVPALVVAGEHDQVEPAGVLRDNLVPYLARADFVVVPRTGHLIPL
                     EAP"
     CDS_motif       9041..9094
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE283_RS00885_0001"
                     /evalue="4.90E-07"
                     /label="NRPS-te1"
                     /locus_tag="IE283_RS00885"
                     /protein_end="103"
                     /protein_start="85"
                     /score="22.3"
                     /tool="antismash"
                     /translation="YVLVGHSMGGKVAQLVAA"
     gene            9756..9917
                     /gene="lanA"
                     /locus_tag="IE283_RS00890"
                     /old_locus_tag="GCM10010348_01910"
     CDS             9756..9917
                     /codon_start=1
                     /gene="lanA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) strep_PEQAXS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978597.1"
                     /locus_tag="IE283_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01910"
                     /product="SCO0268 family class II lanthipeptide"
                     /protein_id="WP_003978597.1"
                     /sec_met_domain="strep_PEQAXS (E-value: 2.1e-41, bitscore:
                     136.0, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTEIVLSHEAPELDLDLDLRVSDLPEQAASFGEGTFTSPSSYAI
                     GTRCPICC"
     CDS_motif       9756..9842
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRTEIVLSHEAPELDLDLDLRVSDLPEQA"
                     /locus_tag="IE283_RS00890_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9843..9917
                     /prepeptide="core"
                     /locus_tag="IE283_RS00890_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.70"
                     /molecular_weight="2329.6"
                     /monoisotopic_mass="2328.1"
                     /core_sequence="ASFGEGTFTSPSSYAIGTRCPICC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRTEIVLSHEAPELDLDLDLRVSDLPEQA"
                     /leader_location="[9755:9842](+)"
                     /alternative_weights="2347.6"
                     /alternative_weights="2365.6"
                     /alternative_weights="2383.7"
                     /alternative_weights="2401.7"
     gene            10001..13162
                     /locus_tag="IE283_RS00895"
                     /old_locus_tag="GCM10010348_01920"
     CDS             10001..13162
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978596.1"
                     /locus_tag="IE283_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01920"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_193484230.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.1e-172,
                     bitscore: 569.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2e-21,
                     bitscore: 72.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.5e-34, bitscore:
                     113.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAESEAHRAAAVFEVREPVLVRMASRPRGAAPATVDAAEPVSGA
                     RQLAADPLLGQAVRVASGSLAHSLARLTTDEGASALGRKRTLSAARTLTRYARRAGARP
                     TPFGLFAGVGAARFGSVAKAGPGTGEVAVRLDGAWLRRRVLAWLEEPSVRRRVDVVLND
                     LCFVRDGRLYLRTGAQEQSVRDNALVGAVRERARNPVPYADLLVSLAERFPALDAERLD
                     GQLAGLLQHGFLLTSITPHRIDVALLDGIEAVLDGALPDDARALRDVRAACARHQQDPP
                     GMGGDSWQDALDAVRRLDVPGTGDDAHARPPLHVDLHVPGAFVVPEAVGREVCRYAAAI
                     WAITPQWTTLAYMRDYRERFIERYGTACAVPLGELVDPHRGLGLPSEYGAEPVYAHGGP
                     GDEADGPRRAMIGELLQEAVLSGGDLVLTDEVVGRLGEVAGHDPAAAPPRSLELCFQVL
                     SESTAALDRGEFRLLGSPHIGAWTAGATAGRFAAAAGLTDELARLAAESTDDTVITAQV
                     ELMPHEPRGLNIVQVPRLLPYRIPVGVPDDRRDPRCLDWRSLLVAAGSDGLRLLDPRSG
                     RPVRPVLPHMLALDTQAPPVARFLMDLATARPRVWSGWNWAGHDALPYLPRVRYGRVVA
                     VPGRWLPGRRLRDAARAQGAGAWEQGLDAWRRRLAVPDRLQIARNDQMYPVDLRERWDR
                     DLLRAELTAAQPRFVLYEDLTADGAGLGWNGGHSTEIVVPLAAARRAAGRTAPGRAEPA
                     RGRTVPPGRPVPVRPAPVRIHLPGEDWLLVKWYAEPSAHDALLTEHLPALLSEVEDEVD
                     RWFFLRYQDPEPHLRLRFHGDPGALNGRVLPAISRVTRALVESGALRTMALDTYRPESD
                     RYGGEAVQEAAERFFRTDSLSALVQLRALRGPARALPGAVLAGLGHAVLLESLGDWDWC
                     GWVDRMFTKTVEHEVYQRHRAVADRLIGPGRAVSSAAAALGAPSLGALWSESPEPRAYG
                     ELILSAPEADRDEALLSLLHMRHNRLFGIDRAAEARGYAVLRGAVRTHAGRRRHESGSG
                     IGSGR"
     aSDomain        10475..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE283_RS00895_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.40E-23"
                     /identifier="RREFam001.1"
                     /label="IE283_RS00895"
                     /locus_tag="IE283_RS00895"
                     /protein_end="241"
                     /protein_start="158"
                     /score="72.8"
                     /tool="antismash"
                     /translation="VVLNDLCFVRDGRLYLRTGAQEQSVRDNALVGAVRERARNPVPYA
                     DLLVSLAERFPALDAERLDGQLAGLLQHGFLLTSITPH"
     gene            13159..14559
                     /locus_tag="IE283_RS00900"
                     /old_locus_tag="GCM10010348_01930"
     CDS             13159..14559
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026975.1"
                     /locus_tag="IE283_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01930"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_011026975.1"
                     /sec_met_domain="LANC_like (E-value: 3.4e-63, bitscore:
                     209.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTTEGGSPEHTMDGFSGSGTREAPAGESPRALRERAGAVSAEI
                     LDRLADPAATVAATRIPAQAADDGVAEPIWAELTLGSGSPGLALAFAGASRDAARQVPR
                     AHAYLTAGTRAVSGRPGTAGGVFKGPGALAFAVLLAHRTTGGYVSALQRFDAYQRDLVR
                     TVLPPVEDRPLPTIGHYEVVRGLTGVGRYLLARAESCEEPLTAVLDYLVRLSLGTVEHQ
                     GADVPRWWALDAPRIGSEAAFPGGHLNLGLSHGVAGPLALLALAWEQGVRVPRQREAME
                     ATAALLRTWAVADRYGLFWPGYLSFAQWQRGPAAYDGTAKWPAWCYGAPGVSRALQLAG
                     RALGRADFSDLARASVERLLVLPRPAWGIDDHALCHGWAGALHQLGRLNEGWQDSRLAE
                     LRDGIAADLVSAFDPELPFGLRFTMTKVPFGSDVSGYLDGAAGVALALDSYAAAGTPAD
                     WDMPLLLA"
     misc_feature    complement(14572..14587)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     misc_feature    14736..14752
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            14841..15794
                     /locus_tag="IE283_RS00905"
                     /old_locus_tag="GCM10010348_01940"
     CDS             14841..15794
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325044.1"
                     /locus_tag="IE283_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01940"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_016325044.1"
                     /transl_table=11
                     /translation="MGAHTAVAPPHPGAGTSPGGASAPRRTRRPRDDRKAAWLFLAPAL
                     LGFALFYAYPTVRGIYYSLTDYSLIATPDFVGGDNYSRLIGDEQFWNALQVTGYYVLVN
                     IVSQTLLALVLATLMHRLTRSVALRAMLLVPWLVPNVTVGLLWMWLLDTNLGLVNHVLN
                     AMGMGTTGFFTSPDWAMPSVAAVNTWAYTGYTALLLYAGMLQVPQYLYESASLDGAGEW
                     RMFTRITLPLLRPVLSLVLVVSLIGSFQIFDTIAVTTKGGPVSATRVIYYYIYEQAFTN
                     FHMGYASAVAVVLALILGVLTAVQMRLLRASRSDLA"
     gene            15805..16695
                     /locus_tag="IE283_RS00910"
                     /old_locus_tag="GCM10010348_01950"
     CDS             15805..16695
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978593.1"
                     /locus_tag="IE283_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01950"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_003978593.1"
                     /transl_table=11
                     /translation="MTRIRTRVSPGRIAAWALLVVALFATVFPFYWMVRTALTPAADLY
                     TDSTGLVPDHPTMINFLRVLGLTSQEEAVAAGGSGAQVDFLRYLLNSVVYSGLIAVLQT
                     LFCAMAGYAFARLRFPGRDLVFGVLIAALMVPPIFTVLPNFVLVKDLGWLNTFVGMVAP
                     SVLMTPFAVFFLRQFFLSVPREVEEAAILDGVGPWGIFWRVVMPMTRGPLLTVGLTTTV
                     WAWKDYLWPLLSGRDEETRVLTVALGIFQQQSPNTQPDWTGLMAGSALSVLPVLVLLIL
                     LGRRLVESLNFTGMK"
     gene            16760..18109
                     /locus_tag="IE283_RS00915"
                     /old_locus_tag="GCM10010348_01960"
     CDS             16760..18109
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978592.1"
                     /locus_tag="IE283_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01960"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_030862253.1"
                     /transl_table=11
                     /translation="MRPRHLRAGAALLCLTALTTLVSCGSSDEAGDGRTTVDYWLWDDL
                     QLPAYQECATAFEKANPDIAVRITQTAWNQYWQNLTTQLVSGEAPDVWTNQATYYPQFA
                     AGNQLLDLQPYVERDGLDVSAYQAGLADTWVKDDKRYGLPKDWDTMAVVYNTDMLKRQG
                     VDLAALNDLTWNPADGGTLEQVIARATVDSEGRNGLDPAFDKDHVEVYGFLPEWADGAQ
                     GQNGWGNFAAANGFEYLDKNPWGTHYKFDDPRLAETVSWFRHLIDKGYAPRLDQQSSVA
                     RTELLIAGKGAMSLAGSFTVSSFTGPKVKQDFGFAAMPVGPAGRKSALNGLADSVWAGT
                     DHKEEAWKWVKYLASADCQDRVAAHGVVFPALKSSTEKALAAHEADGDDVRAFTDAVGT
                     KGVTFQLPVTEHGTEISPLVQDAIQSAILGQEDAADALESVNGKVNGLFD"
     gene            18236..19735
                     /locus_tag="IE283_RS00920"
                     /old_locus_tag="GCM10010348_01970"
     CDS             18236..19735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026979.1"
                     /locus_tag="IE283_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01970"
                     /product="glycoside hydrolase family 36 protein"
                     /protein_id="WP_193484232.1"
                     /transl_table=11
                     /translation="MAQLVELGGRTLAVELAGDAPPRAVEGGLLLPPGRTAVLHGLRDA
                     LFYRHGHNSWSPCGWRRLSEAPLRIESAERRLTADDTVWDDPARHHSSAVAALEGPDGR
                     VLLLGALGLDVPRLTADRDTLTGWCERDGAPWFLALGSEEEVFAAYARHLGDRLGRSDK
                     RAGNVWCSWYAYYESITEEQLTKDVTALRGLPFDVVQVDDGWERAVGDWEANDKFPSGM
                     RALADRITDAGLRPGLWIAPFIVLPGSRTARQRPELLLRDGRGEPVVAGHNWGVGYWTL
                     DLTLPAAQEHLRETIRRVVREWGFTYLKLDFVGAGAVPGVRFADVGREEAYRTGLSIVR
                     EAAGPDAYLLGSGAPLLPSLGLVDAIRSGPDVAPMWEHYATQDPSDALARNAVVNTVHR
                     LWQSPLLEVDPDVVYFRSRLNLLTEQQQGLLRDLADVCGFRAVSDPPGWLLPEELKAME
                     AYLTGRPEVRRLGRYRFALDGREVDFGAAVTPGDEQRYPLA"
     gene            19828..20985
                     /locus_tag="IE283_RS00925"
                     /old_locus_tag="GCM10010348_01980"
     CDS             19828..20985
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026980.1"
                     /locus_tag="IE283_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01980"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_011026980.1"
                     /transl_table=11
                     /translation="MATTGTDMSRMREMNQLSIVGALRGNPPSTVTELASRSGLSRPAV
                     DVLVQSLVADGWAEVEEPGASSVVGRPARRYRFRATAGHVLGIDIGVHKILVILSDLEG
                     NLVRTVRHPAAPEAAPAERLAAVDRVVDEVLASAGMAAGDIWAVTVGVTGPVDRSGRTS
                     LSSPLPGWSEADPAAHLGTRFSCPVQVENDCKLAAVAERWRGVAQDADDIVYLLAGLRT
                     GAGLILDGTLRRGHGGAAGEIGALKAVRWLTAPDHLQSCPGMPATAAEGEAAAWVFQAA
                     RDGDRDARTAVRRYTRDLAVGVAALVLALDPQVVVYGGGFSRSADVVLGPLHRELTKHC
                     LRMPELRASTLGDESVALGAVRLALDEVDSRLLSDGLAAPTAPRR"
     gene            21057..22310
                     /locus_tag="IE283_RS00930"
                     /old_locus_tag="GCM10010348_01990"
     CDS             21057..22310
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026981.1"
                     /locus_tag="IE283_RS00930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_01990"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_011026981.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.9e-21, bitscore:
                     73.3, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.6e-20,
                     bitscore: 69.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRDQIPDRHLRVGVVGVGQRADMAALVNRSGAARIVSCADPDP
                     RGREDARRLFGADVVVHDRYERMLDDELDAVFVLTPDHLHTEPALCFLAAGVAVFVEKP
                     LTITVADCDALLMAAFRSRTRLYVGHNLRHLPVLRRMRELIDDGAVGRVRAVWCRHFVG
                     HGGDFYFKDWHAQRANTTGLLLQKGAHDLDVVHWLAGGFSRNVVAQGALAVYGDNPRRA
                     TQETVPPGQRMPDWFDPEVWPPSALRDLNPVVDVEDISMMLARLDNGVLASYQQCHFTP
                     DYWRNYTVIGDEGRLENFGDGIDGDAARVDVWNRRRSGYRADADLSVPVVASDEETHGG
                     ADRALVEEFLRFAAAGGPTETSPVAAREAVAAAVAATTSLRSGSTPVDVPPLDPAIVRH
                     FAEHQPAEGADGSGPQPR"
     gene            complement(22492..23160)
                     /locus_tag="IE283_RS00935"
                     /old_locus_tag="GCM10010348_02000"
     CDS             complement(22492..23160)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026982.1"
                     /locus_tag="IE283_RS00935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_02000"
                     /product="peptidase E"
                     /protein_id="WP_030862270.1"
                     /transl_table=11
                     /translation="MNFLLTASGLRNETLRDALRDMLGKPFGSANVVFVPTASVADPGD
                     HGWVVADMNRLHGLGWREFDILELNGLPQQMVLDRLLHADVVYVEGGNHYHLARSITGN
                     GLADGFLEALQSRVYVGVSAGSMIFSRNLTGHSADVIGDATDLHVLGATSVEPPFGLFD
                     WYLKPHLYSPDFPERDDAWADRITARADFPIYFIDDETAVRVRDGKADVVSEGRWRFHP
                     "
     gene            23255..23869
                     /locus_tag="IE283_RS40170"
                     /old_locus_tag="GCM10010348_02010"
     CDS             23255..23869
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026983.1"
                     /locus_tag="IE283_RS40170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010348_02010"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_193484234.1"
                     /transl_table=11
                     /translation="MTSSDHPLRASLDEPRAHLLDLIGAVEPWDDLEHTHLESARHWIA
                     GGAPLYRVRKPDVPPMHLVSYFAVLDDTRGQLLLVAHRKAGLWLPAGGHVESGEDPWAA
                     VVRECREELGIEAVASPVAGELPFFLTVTGTRGQGPHTDVSLWYLLDADAHTVTDYDRG
                     EFSAVRWLTHEQVLAASAELLDPHMHRFARKLAWARAGRGG"
     misc_feature    complement(24434..24448)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     misc_feature    24435..24449
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
ORIGIN
        1 cgccacggca tcaccgtcaa cgcgtactgc ccgggcatcg tcggcaccga catgtgggac
       61 ctgatcgacg agcggctggc cgaggaggcg ggcatcgaga agggccaggc catcaagaag
      121 cacgcggagt cgatcgccct cggccgggtc gaggaacccg ccgacgtagc ggccttcgtc
      181 tcctacctgg cctcacggga ctcggactac atgaccggcc agtcggtgat gatcgacggc
      241 ggtatccagt tcgcctgacc cgcgccgtcc ggcccttctg ccccgcaccg ccgaacaccg
      301 gcccgttcgg cccaccgtcc accgcgaacc gaggagtgac cgatgtattc caaggacggc
      361 gagaactatt tcatcgtgga cgcgcacgtc gccctctggg acgcgcgccg cgagaaccag
      421 cgcaacatcc acggcaagca gttcatcgac tgcttctacg actaccaccg caacctgagc
      481 ccggcgtcgg agctctggcc gtacgaggac ttcctgtacc agggcggcga gcggctgatg
      541 aaggacctgt tcaccgacgg gtacgtggac cacgcgatct tccagccggc gcatctcggg
      601 gcgttctaca acaccggctt cgggcagacc gaggaggcct tcgcgctcac gcgcaagcat
      661 cccggcatgc tcacctacaa ccactgcttc gacccgcgct tcgaggaggc gggcctgaag
      721 caactgcgcg aggacgccgc ccgcttcggc ctgaagggcg tcaagctcta caccgccgag
      781 tggaagggcg actcccgcgg ctacaagctc agcgacccgt ggacctaccg ctacctggac
      841 gcctgccggg agctgggcat caagaacatc cacgtccaca agggccccac catccggccg
      901 ctggaccggg acgccttcga cgtggccgac gtcgacgcgg cagccagcga cttcaccgac
      961 ctgaacttcg tggtcgagca ctgcggtctg ccccgcctcg aggacttctg ctggatcgcc
     1021 acccaggagc ccaacgtgca cgcggggctc gccgtcgcga tcccgttcat gcacacccgg
     1081 ccccgctact tcgcgcagat catcggcgag ctgctgtact ggctggacga ggaccgcatc
     1141 cagttctcca gcgactacgc gctgtggacg cccaggtgga tcgtcgagca gttcgtcgac
     1201 ttccggatcc ccgacgacat gacgggcgag tacccgcagc tcaccgtcgc ccagaagaag
     1261 aagatcctcg ggctgaacgc ggccgccatg tacgacatcg aggtcccggc gggcctcggc
     1321 ctcgccgagc cggcggtggt ctgacatgtg ggccgcgcaa ctcgaggtgg cggcgcgcgc
     1381 cgcgctcgac acggtgtacg accccgagct ggacgagccc gtcaccgacc tcggcttcgt
     1441 gcgctcgctg accgccgagg acggccgcgt caccgtgcac ctgcggctgc cgacctcgtt
     1501 ctgctcaccg aacttcgcgt acctcatggc ctccgacgcc aaggacgcgc tcagcgccct
     1561 gcccggtgcc cgggaggtca cggtcctgct cgacgaccac cacgactccg atctcatcaa
     1621 ccgggggctg gccgccgacg ccgggtaccg cggcaccttc ggccacgagg cggagcagga
     1681 cctggaggag ctgcggggca tcttccggcg caaggcgcac accgccgcga tggaacgggc
     1741 gctcaccgcg ctgctgcgcg cccggcccga cctggccgag gaacagctcg gcgacgtcgt
     1801 cctcggcgac ctgccggaca cctctgccac ccgggcactg ctgcgccgcc gcgccgccct
     1861 cgggctcggc accgcccctg ccgacccggc gctcgtggac gacgacggcc ggccctgccc
     1921 gcggggggag gtcccgttgc ggctgcggtt cgcccgctcc gtgcgcatct ccatcgacgg
     1981 caacgcccac ttctgccggg gcctgctgcg cacccggtac ccgcagtccg cggccgacca
     2041 gtccgcgcgc ccggaggagt tccccgcggg cggggaaccc gtaggggccg gggaaaccgt
     2101 acccgcgggt gagctcttcc ggctctccgc tccggcgaag gagaacgtct cgtgaaagca
     2161 gtccaggtgg tgggctacgg caagaacctc gagatggccg aggtcccggc ccccgaggtc
     2221 accggcccgt acgacgtgat cgtcaggatc ggcggcgccg gggtgtgccg taccgacctc
     2281 cacatcctgg aggggcagtg ggccgagaag tcgggggtgg agctgccgta cacgatcggt
     2341 cacgagaacg ccggatgggt gcacgcggtc ggcagcgccg tcaccaacgt gtccgagggc
     2401 gacaaggtca tcgtgcaccc gctgatcacc tgcgggctgt gccgggcgtg ccgggccggt
     2461 gacgatgtgc actgcgagaa caaccggttc ccgggcatcg acaccgcggg cggttacgcc
     2521 gagtatctga agacctccgc gcgcagtgtc gtacggctcg acgactccct cgaaccggcg
     2581 gacgtcgccg ctctcgccga cgcgggcctc acggcgtacc acgcggcggc caaggcggcc
     2641 cggagactga ggccgggcga ccgctgcgtc gtgatcggcg cgggcggtct cgggcacatc
     2701 ggcatccagg tgctgggcgc cctcaccgcc gccgagatcg tcgtcgtcga ccgcaatccc
     2761 gacgcggtcg acctggccgt ctccgtcggg gccgaccacg gtgtcctcgc cgacggcggc
     2821 cacgtggacc gggtgcgcga gctgaccggc gggcacggag cggaagcggt gatcgacttc
     2881 gtcggtgagg gcggctccac cggggacggc atcggcatgc tgcgtcgggc cggcgactac
     2941 cacgtggtcg gttacggcga gaacatcgac gtcccgacca tcgacgtcat ctccgccgag
     3001 atcaacttca tcggcaacct cgtcggttcc tacaacgacc tgtgcgagct gatggtcctc
     3061 gcggcgcggg gccgcgtgcg cctgcacacc gccaagtact ctctcgaccg tttccaggac
     3121 gccctggacg acctggacgg cggccgcatc cggggccgcg cgatccttgt cccgtgaccc
     3181 ggccccgggt gacggagccc cgagcacgca caacgaagga agcaagacct tgatcttcat
     3241 caccgcgaag ttccgtgtcc tccccgagca tgccgaccaa tggccgcagg tcgtggagga
     3301 cttcacccgc gcgacgcggg ccgaaccggg atgtctgtgg ttcgactggt cccgcagcct
     3361 cgacgacccg accgagtacg tcctcgtgga agccttccgg gacgacgagg ccggtgcggc
     3421 ccacgtgggc tcggcgcact tcaaggcggc ccagcagacg ctgccgcccc acctcgcgac
     3481 gacccccagg atcgtcaacg ccaacgtgcc ccaggacgac tggtcgctgc tcggcgagat
     3541 ggcggtcgac gcgggctgac gccggcgagc gtggcagagg ggcgacagcc ggtcgtacgg
     3601 ctgccgcccc ctcggccggt ccggcggccc ggccgaggtc agccgatctg cttgatcacg
     3661 cgggcgggca ctcccgcgac gacggtgccc gcagggacat cacgggtgac caccgcaccg
     3721 gcagccacta ccgcgcccgc accgatggtc accccctgcg tgatcacggc ggccgtgccg
     3781 atccacacgt cgtcctcgac gacgatcggg gcgaaggaga ggtgtgcgcg gcgctcggcc
     3841 aggggcagcg gatggcctcc ggtgacgagg ctggccttcg gggcgatcat gactcggttc
     3901 ccgatgcgga tgcctccctt gtccatgaag gtgcatccct gattgacgaa gacgttctcc
     3961 ccgaacgtcg tgttcagccc gtactcggtg aagaacggcg ggtagatcgt caccgattcc
     4021 ggcagcgggc ctccgaacac aacggaaagt agttccgaac gacctgcact gtcgctgaac
     4081 ggaagcacgt tcagtcgaga cgtcgcatcg gtcacctcca cgatccgctc cgcatgacgt
     4141 gcgaactcgg gcgtatggac atacatgatc tgctctgtgc gggtggacat gcgccgatcc
     4201 catcaccgcg cggaaccttc gatcaaacaa ccctcaccgc atcggacaca acccgcagtt
     4261 gtggaagtag gctgatggcg tggatgtgga agcgctgcga acgttcgtgg tcgtcgccgg
     4321 ggtcggccag ttccaggccg ccgccgacga gctggggatc agccagcagg cggtctccaa
     4381 gcggatcgcg gccctggaga ggcatgtcgc ggtcacgctc gtggtgcgaa gttcccgagg
     4441 ctcccggctg agcctggacg ggcaggtctt cctgccgcac gccaagaagg tcctgaccgc
     4501 cgtcgagcag gccgagcggg ccgtcaaccc cggaagccgc ccgttgcgcg tcgatgtcct
     4561 caatcggcgc atctcccccg cccaggccgt ctaccggttc taccgctccc gccccgagac
     4621 ggacctggac gcggtcacgc tggacaagga gaacgccgca caggccgcac aggcggtgct
     4681 cgaaggggtg gtcgacgcgt ccttccgcgc cttgccggca gaccgggtcc cgaccgggat
     4741 caccgccgaa cgactcctgg acgaacccct ggaactgctc gtcggccccg gccacccgct
     4801 ggccgacgcg ccccggatca gcccggtgga cctggccggc caccgcatct ggatccccgg
     4861 gatcaggccg ggtacggagt gggccgcgtt ctaccaggca ctgtccgagg ccttcggcct
     4921 gagcatcgac gcgctcggcc ccaacttcgg tgacgaggcc ctgatggacg cgctggccga
     4981 ctcggcctca ctggccaccc tcgtcgggcg gggagaccgg tatctgtggc cccgaaccca
     5041 cgatctgcgg cgcatcccgt tgcacgaccc gacgccgttc tacccgcacc tgctgctgtt
     5101 ccgcaccgga gaccggcacc ccgtgctgac cgcgctgcgt gaccacctgc gcaccacggc
     5161 cccgcgcacc ccgcacgacg cgtggacgcc ggactggaca gtgacagtgc actgatcgtg
     5221 cgtctcccgg accggcattc agggcaggta ctgctcaatg ctgcggtggc ggacgacgcc
     5281 gtgcgcgaag tcgggtacgt gtgcggtgcc ctcccgcagg tcgtccagga accgttggta
     5341 ggcgtgggcg accgcatagg ccggcgcgtc ggcccggggt tccagtcgcg cgacacgggc
     5401 gtacgcttcc ggcaccgtca ggggtgcgag ggcggtggac gttccgcggc cgccctccag
     5461 ggtgagcggg ctgagctgcg ggtggccgac cggggcggtg aggacgaggt cgccctcggt
     5521 gccattgatc tcccagcgga aattggttcc ccgggacatt cctccgcggt agtggaatgt
     5581 ggcgaccgct ccgcccggca gccgtcccga ggccaccacc tggtctgcgg cggtcatcgg
     5641 cacgggccgc ccggtctcgg tgtccacggc cgacgtacgc cgggacgccg cctggatccg
     5701 cagttcctcg ggctctccga ggaccgaggc gactccgtcg agggcgtgac cgaagggaac
     5761 ggtcagcagc gtcgcgccgt tcgccgcgtc gagtacatgg tggtcggcgg ggccgacggt
     5821 ggcgccccaa gcgccgccgg agccgacgac cgtcgtggac agcacctccc ccacgtaacc
     5881 gtcggccacg agatgccggg tgtaggcgaa cgccgggtgg gaccgtgcct ggagaccgac
     5941 gacggtcggc acggcgtgag cgcgagccaa ccgcgccatg tcctccgcct cggcgagccc
     6001 gttgcccagc ggccactcgc acagcacgct cttgccggcg ttcagcaccg tccgtacgag
     6061 ttcccggtgg tgcggcacct tcaccgccac gaccacgagg tccacctcgt cgcaggccgc
     6121 cagttcggcg gccgtaccga aggcacggcg cacaccgtgc ttgtgtccgg agcgctccgc
     6181 cgattgcttc gaactcgtgc tcagggcccg cagctcgaat cccccgacgg cacgcagggc
     6241 ggggaggtga gagcgttcgg cccagctccc gtgcgccccg agtcctatga ctcccacgcc
     6301 gatgggcctg ccggagcggg ccaggtcggc aagcgctgac ccgggtgtgt tcatgattcg
     6361 tcaccttttc caacggacct gctagcgttg acatctcaac actaggaagg gtgcgttgac
     6421 atgtcaacac gcggccgggc tcccgatccg caggagggca cgagcgaggc agcactggat
     6481 cccgtcggtc tgtggtccgc cttcaagcgc gcccacgagg tggtccgaac ccgcgtgata
     6541 gccgacgccg cggaggcggc gggcctctcc gagccggacc tgaccatcct cgccgacctc
     6601 aacaaggcgg gaggcgcctt gcgccagagc gaactcgccg cgtcgctcgg ctgggaccgc
     6661 acccgcgtct cccaccagct cacccgcatg agcaagcgcg aactcgtcac ccggcggcgc
     6721 gccaacggcg tgatcgtcgc tctcacggac gccgggcatc aggccatcac cgccgtgtac
     6781 cccggcctgg acgccgcggt acgccgccac ttcaccgaca agctctccac gcaggaggtc
     6841 gaaacactgg ccgccgtcct tggccggctg taaccgtccc ggccccgcca ccacacggtg
     6901 tgccggcgcg acgggcgaga gtcaccacgg agtgtcacgc tggatcacac aggaactgcg
     6961 aaagggaacg tccgtgatca ccaacgactt cgcccccggc tccccctgct ggctcgacct
     7021 cgggtccccg gacgtcgccg ggacggtggc cttctacggc ggcgtgttcg ggtggacgta
     7081 cgaggccatg ggggaagacg cggaaggcgg catgttccgc aaggacggca agatcgtcgc
     7141 cggtctcggc aggctcaccg aagaaggcgc gcgctccgcc tggatgatct actactccgt
     7201 caccgacgcg gacgccacca ctcaggcggt gcagcgcgcc ggcggcacgg tgcgggtggc
     7261 gccgacggac ctggacgact ggggccggat ggctcagtac agtgacccgt ccggcggtca
     7321 gttcgccgta tggcagccgg gccggaccag gggcgtcgag ctcgtggacc agcccgggac
     7381 gctgtgctgg acggagctgt acacgagcga cgccgcggcg gccaaggagt tctacggcgg
     7441 ggtcctgggc tggcggttcg gcgacatggc ggtgccgggc ggcgaaggca cgtactccct
     7501 catcactcct tccggcctgt ccgaggaccg gatgcacggc ggcctgatgc agctcgacga
     7561 gcgggatctc accctgacgg gcggccgggc gtactggcac ccggtgttcg ccgtcaccga
     7621 ctgcgacgcc gcggtctccg cggtcacggc gcatggcggc agcgtgcaga tggggcctgc
     7681 cgacgcggag ggcgtcggac gtctggcggt gtgcctcgat ccgtcgaagg cggacttcgt
     7741 ggtgctggct ccggcctcgg gatgaccacc tgggcgcggg ggccgggcag cccccgccgc
     7801 ggctgatcac gtgacgggct ccggcggcgt cgaggcggtc ggaaccccgg ggccggtggc
     7861 cgccgcctgc cacgcgcccg gacgctcgcc cgtggccttg tggaagaaca ccgagaagtt
     7921 ggacgcgtcg gggaagccca ggacgccggc gcagcgggcg gcggtgagtc gctcgtgcgc
     7981 gaggagccgc ttggcctcca gcacgagccg ttccacgacg tatgccttcg ccgtacggcc
     8041 ggtggcctgc cgcaccgcac gtgagagggt gcggggcgcg tatcccagcg tgcgggcgta
     8101 gtagccggcg tcgtggtgct gccggaagtt cgcctcgacg ctggagcgga acaggcggaa
     8161 caccggatgg gcgagtcgtg cttcggcgtg cggcgggtgc agccgcgcga tgagtgcgga
     8221 gagcaggatc gcgggcagtt ccgtcgagga gtcactcggt ggggcggacg cttcgaggcg
     8281 gagatggccg cgcgccgcgt cgacgaaggg ccagtcggcg gcggggacga tccagtgcgc
     8341 tgccgggtcg ggggaggcga cgagttcgcg ggtggcgtgg gtgacgggag cggtcggcac
     8401 gaacagtacg aggtccccct ccacctcggc gacgtcgtcc caccggtgca ccgcgccggg
     8461 gggaatccac accgcggacc ggtcctggag ggggtggagg cggaagtcga ccgtgacgga
     8521 gccgcgtccg gcgtcgacga cggcaaggac gtggaagtcg gcgcgctgcg tgccgccgtc
     8581 gttcagctcg cggaggcggc cgaacgtcat cgtctcgacc gaggcggcgc cgcggccggg
     8641 gggctggtag gtcatctgcc ggatctcgct cacgtgtcca gttttcacca tcgcgcgacc
     8701 gctcacgccg atgcccggtc cgggtgcgag gggttcgatg gacacacggg gcagccgccc
     8761 cgggcatcga acgagaagag ccatcatgag caccacgcag cacacgcttg tgcccgttta
     8821 cgaccatcgg accgggaccg ggccgaccct tgtgttcctt cactactggg gtggttccgc
     8881 ccgcacctgg gacctcgtcg tcgaccgcct gccgggccgt gccgtggccg cggtcgactt
     8941 ccgcgggtgg ggccggtcga gggcgctccc cggcccctac acgctcggtc ggttcgccga
     9001 cgacacgctc gccgtactcg cggacgcggg catcaccgac tacgtgctgg tgggacattc
     9061 gatggggggt aaggtcgccc agctggtggc ggccacccgg cccgcggggc tgcgcgcaat
     9121 cgttctcgtc ggctccggac ccgcgaagcc cgccgcccgg gtcactcccg agtaccggga
     9181 agccctgtcc cacgcctacg actccgccga gtccgtggcc ggggcacggg accacgtcct
     9241 cacggcgacc gagctgcccg ccgcgctcaa ggcgcggatc gtgaccgatt cacggaacgt
     9301 caccgacgcc gcccgcatcg agtggcccct gcgcggcatc gcgcaggaca tcaccgagca
     9361 cacccgccgg atcgacgtgc ccgctctcgt ggtcgccgga gaacacgacc aggtggaacc
     9421 ggccggtgta ctccgcgaca acctggtgcc ctacctcgcc cgagccgact tcgtggtggt
     9481 cccccgcacc ggacacctga tcccgctgga ggctccggcc gacctggccg acgccgtcac
     9541 cgcgttcgcc acggcggtct gaccgtcccc gcggctccgg gcgggctggg cgcggggccc
     9601 gttgcgcccc atatccccgc gagcggccga cacttgatca atggctcgtt ttcgtctacc
     9661 gactgtcagt ggcgtgggca atggttgcgc atgtccgggc cccgaccggg gccctgcgtt
     9721 tcgagtccgt gcaccccaac acccaaggga gaagcatgcg taccgagatc gttctgtccc
     9781 acgaagcccc cgagctcgac ctcgacctgg acctgcgcgt ctccgatctc ccggagcagg
     9841 ccgcgtcgtt cggcgagggc accttcacgt cgccgagcag ctacgcgatc ggcacgcgct
     9901 gccccatctg ctgctgacgg accgaggccc cctcggggct cttccgagcg gggcggcccg
     9961 agtccgcccc gctttccgta cgacggcgag gagcacacac gtggcggcgg agtccgaagc
    10021 ccaccgggca gcagcggtct tcgaggtacg ggagcccgta ctggtccgga tggcgagccg
    10081 gccgcgggga gccgctccgg ccacggtcga cgcggccgag ccggtctccg gagcgcggca
    10141 gctcgccgcc gatcccctgc tcggccaggc ggtccgggtc gccagcggct cgctggccca
    10201 cagcctggcc cgtctgacca ctgacgaggg cgcctccgcc ctggggcgca agcggaccct
    10261 gagcgccgcg cggaccctga cccggtacgc ccgccgcgcc ggggcgcgcc ccaccccgtt
    10321 cggcctgttc gcgggtgtcg gcgcggcccg gttcggttcc gtggccaagg ccgggccggg
    10381 gaccggtgag gtcgcggtcc ggctcgacgg ggcgtggctg cgccgacggg tactggcctg
    10441 gctcgaggag ccgtccgtcc gccggcgcgt ggacgtcgta ctcaacgacc tgtgtttcgt
    10501 gcgggacggg cggctgtatc tgcgtaccgg tgcgcaggag cagtcggtgc gcgacaacgc
    10561 gctggtcggc gccgtgcgcg agcgggcgcg gaatccggtg ccgtacgcgg acctcctcgt
    10621 gtcgctggcg gaacgcttcc cggcgctgga cgccgagcgg ctcgacggtc agctggccgg
    10681 tctcctgcaa cacggcttcc tgctcacctc gatcaccccg caccgcatcg acgtcgcgct
    10741 gctcgacggc atcgaggcgg tcctggacgg ggcgcttccc gacgacgcgc gggcgctgcg
    10801 ggacgtacgg gcggcctgcg cccggcatca gcaggatcct ccggggatgg gcggcgactc
    10861 ctggcaggac gccctggacg cggtccgccg gctcgatgtc cccggaacgg gcgacgacgc
    10921 gcacgcccgg ccgcctctgc acgtggatct gcacgtgccc ggggcgttcg tcgtccccga
    10981 ggcagtcggc cgggaggtgt gccggtacgc ggccgcgatc tgggcgatca ccccgcagtg
    11041 gacgacgctg gcgtacatgc gggactaccg cgaacgtttc atcgagcgct acggcaccgc
    11101 ctgtgccgtg ccgttgggcg agctggtcga cccgcaccgc ggactcggcc tgccctccga
    11161 gtacggcgcg gagccggtgt acgcgcacgg cggccccggc gacgaggcgg acgggcccag
    11221 gcgcgcgatg atcggcgagc tgttgcagga ggccgtcctg tccggcggtg acctggtgct
    11281 gaccgacgag gtcgtagggc gtctcggcga ggtcgccggg cacgatcccg cagccgcgcc
    11341 gccgcgcagc ctcgaactct gcttccaggt gctctccgag agcaccgcgg cgctggaccg
    11401 cggtgagttc cggctgctcg gcagcccgca catcggcgcc tggaccgcgg gcgccaccgc
    11461 ggggcggttc gcggcggcgg ccggcctcac cgacgaactc gcccggctgg ccgccgagag
    11521 caccgacgac acggtgatca cggcgcaggt cgagctgatg ccccacgagc cgcgcgggct
    11581 caacatcgtc caagtgcccc ggctgctgcc gtaccgcatc cccgtcggcg tacccgacga
    11641 ccggcgcgac ccccgctgtc tggactggcg ctcgctgctc gtcgccgccg gctccgacgg
    11701 actgcggctg ctggatccgc ggagcggccg tccggtccgt cccgtgctgc cgcacatgct
    11761 ggccctggac acgcaggcgc cgccggtggc ccggttcctc atggatctcg cgaccgcccg
    11821 gccccgcgtg tggtcgggct ggaactgggc ggggcacgac gcgctgccgt atctgccgcg
    11881 ggtccggtac gggcgggtgg tggccgtgcc cgggcgctgg ctgccgggcc gacggctgcg
    11941 cgacgcggcc cgggcacagg gcgccggggc atgggagcag ggcctcgacg cctggcgacg
    12001 gcggctggcc gtaccggacc ggctgcagat cgcgcgcaac gaccagatgt accccgtcga
    12061 cctgcgtgag cgttgggacc gggacctgtt gcgtgccgaa ctgacggccg cacagcctcg
    12121 gttcgtcctc tacgaggatc tgacggcgga cggcgccggg ctcggctgga acggcgggca
    12181 cagcacggag atcgtggtgc ccctcgcggc ggcgcgacgg gccgcggggc gcacggcgcc
    12241 ggggcgtgcc gagccggcgc ggggacggac cgtcccgccc gggcggcccg ttcccgtccg
    12301 gcctgctccg gtccggatcc atctgccggg cgaggactgg ctgctcgtca agtggtacgc
    12361 cgaaccgtcg gcccacgacg ctctgctcac cgagcatctg cccgccctgc tctccgaggt
    12421 ggaggacgag gtcgaccgct ggttcttcct gcgctaccag gaccccgaac cgcatctgcg
    12481 actgcggttc cacggcgacc ccggggcgct gaacggtcgg gtgctgcccg cgatcagccg
    12541 ggtgactcgg gccctcgtcg agagcggtgc cctgcggacg atggccctcg acacgtaccg
    12601 gcccgagagc gaccggtacg ggggcgaggc cgtgcaggag gccgccgagc gcttcttccg
    12661 caccgacagc ctgtcggcgc tcgtgcagtt gcgcgcgctg cggggccccg cgcgggcgct
    12721 ccccggtgcc gtgctcgccg ggctcgggca cgcggtgctg ctggaatccc tcggggactg
    12781 ggactggtgc ggctgggtcg accggatgtt cacgaagacc gtggagcacg aggtctacca
    12841 gcggcaccgg gccgtcgccg accggctgat cgggccgggc cgtgcggtgt cgtcggccgc
    12901 ggcggcactc ggggcgccgt ccctcggcgc gctgtggtcc gagtcgcccg agccgcgcgc
    12961 ctacggggag ttgatcctgt ccgccccgga ggccgaccgc gacgaggccc tcctgtcgct
    13021 gctgcacatg cggcacaacc gcctcttcgg catcgaccgg gcggccgagg cgcgggggta
    13081 cgcggtgctg cgtggcgcgg tacgcaccca tgccggccgc cggcggcacg agagcgggag
    13141 cgggatcggg agcggacgat gagcggcacc accgagggcg ggtcaccgga gcacacgatg
    13201 gacgggttca gcgggagcgg gacgcgcgag gccccggccg gcgagtcccc tcgggccctc
    13261 cgggaacggg ccggagccgt ctccgccgag atcctggacc ggctcgccga ccccgccgcc
    13321 acggtggcgg ccacgcgcat ccccgcccag gcggcggacg acggggtggc cgagccgatc
    13381 tgggccgagc tcaccctcgg cagcggcagc cccgggctgg cgctggcgtt cgcgggcgcc
    13441 tcccgggacg cggcgcggca ggtgccgcgc gcccacgcgt atctcacggc gggaacccgc
    13501 gccgtctcgg ggcggcccgg caccgcgggc ggggtcttca aggggccggg ggccctggcg
    13561 ttcgccgtgc tgctcgccca ccgcaccacc gggggctacg tctccgcgct ccagcgcttc
    13621 gacgcctacc agcgcgacct cgtgcggacc gtcctgccgc ccgtggagga ccggccgctg
    13681 cccaccatcg gtcactacga ggtggtccgt ggtctgaccg gcgtgggccg ctatctgctg
    13741 gcccgcgcgg agagctgcga ggagccgctg acggcggtgc tcgactacct cgtgcgcctg
    13801 tcgctcggca ccgtggagca ccaaggcgcg gacgtgccgc gctggtgggc cctggacgcg
    13861 cccaggatcg gctccgaggc ggcgttcccc ggcggccatc tcaacctggg cctctcgcac
    13921 ggcgtcgccg ggccgctcgc cctgctggcc ctggcctggg agcagggtgt gcgggtgccg
    13981 cggcagcggg aggccatgga ggcgacggcc gcgctgctgc ggacctgggc ggtcgcggac
    14041 cggtacggcc tcttctggcc cggctacctc tccttcgcgc agtggcaacg ggggcccgcc
    14101 gcctacgacg gcaccgcgaa gtggccggcc tggtgctacg gggctcccgg agtttcccgc
    14161 gccctgcaac tggccggacg ggcgctcggc cgggcggact tctccgacct cgcccgcgcc
    14221 tcggtggagc ggctgctggt cctcccccgg ccggcctggg gcatcgacga ccacgcactg
    14281 tgccacggtt gggccggggc gctgcaccag ctcggccggc tcaacgaggg gtggcaggac
    14341 tcgcggctgg ccgaactgcg ggacggcatc gccgccgacc tcgtctccgc cttcgaccct
    14401 gaactgccgt tcggactgcg cttcacgatg acgaaggtgc cgttcggctc cgacgtctcc
    14461 ggctacctcg acggggccgc cggtgtcgcg ctcgccctgg actcgtacgc ggcggccggc
    14521 acaccggccg actgggacat gccgttgctg ctggcctgac ccgcggggcc ggagacgatc
    14581 acgtgaccgc ccgttcacgg cgatccgggc tgccctcggc gttgcggaag gcagccgtct
    14641 tccgcgtcgc ggtctgagag tgcgcatggg ctcagcctcc gggaacggat ggggagtcag
    14701 ccgcccgacg gtgcctggcc tgccgacccg cctcgtcgtt atgcgacagc attgacaaag
    14761 tttcgctctt gctcatcaat atgttgtcca cggtgcccca ctggcaagag gtgcggcgcg
    14821 aatcccttcg gaggggaacc atgggcgcac acacggcggt ggcgccaccg catccaggtg
    14881 ccggtacgtc gccgggcggg gcctcggcgc cgcgccggac tcgccggccc cgcgacgacc
    14941 ggaaggcggc gtggctgttc ctggcgccgg ccctgctcgg cttcgcgctc ttctacgcgt
    15001 atccgaccgt gcggggcatc tactactcgc tcaccgacta cagcctcatc gccacgcccg
    15061 acttcgtcgg cggggacaac tacagccggc tgatcggcga cgagcagttc tggaacgcac
    15121 tgcaggtcac cggctactac gtcctggtga acatcgtgtc gcagaccctg ctggcactgg
    15181 tcctggcgac gctgatgcac cgtctgaccc gatcggtggc actgcgggcg atgctgctgg
    15241 tcccctggct ggtacccaac gtgaccgtgg gcctgctgtg gatgtggctg ctcgacacca
    15301 acctcggcct ggtcaaccat gtactgaacg ccatgggcat gggcaccacg ggcttcttca
    15361 cctcccccga ctgggcgatg ccgagcgtgg ccgcggtcaa cacctgggcc tacaccggct
    15421 acacggcgct gctgctctac gccggcatgc ttcaggtccc gcagtacctc tacgagagcg
    15481 cctcgctgga cggggccggt gagtggcgga tgttcacgag gatcacgctg ccgctgctgc
    15541 ggccggtgct ctcgctggtg ctggtggtgt cgctcatcgg ctcgttccag atcttcgaca
    15601 cgatcgccgt gaccaccaag ggcgggccgg tcagcgccac ccgggtcatc tactactaca
    15661 tctacgaaca ggccttcacc aacttccaca tgggctacgc atccgccgtg gccgtggtgc
    15721 tcgcgctcat cctcggcgtg ctgacggccg tacagatgcg cctgctgcgc gcttcccgct
    15781 cggacctggc ctgaggagca gaccatgaca cgcatcagga ccagagtctc ccccggccgg
    15841 atcgccgcgt gggccctgct cgtcgtcgcg ctgttcgcga ccgtcttccc cttctactgg
    15901 atggtccgca ccgcgctgac cccggcggcc gacctgtaca ccgattccac cgggctggtc
    15961 ccggaccacc ccacgatgat caacttcctg cgggtgctgg gactgaccag ccaggaggaa
    16021 gccgtggcgg ccgggggctc cggcgcgcag gtcgacttcc tgcggtacct gctcaactcg
    16081 gtggtctaca gcgggctgat cgccgtgctg cagacgctgt tctgcgcgat ggccggctac
    16141 gccttcgccc ggctgcgctt ccccggccga gacctggtct tcggggtgct gatcgccgcg
    16201 ctgatggtgc ccccgatctt caccgtgctg cccaacttcg tgctggtgaa ggacctgggc
    16261 tggctgaaca ccttcgtcgg catggtcgcg ccgagcgtgc tgatgacgcc gttcgcggtc
    16321 ttcttcctgc ggcagttctt cctgtcggtc ccccgcgagg tggaggaggc cgcgatcctg
    16381 gacggcgtgg gtccctgggg gatcttctgg cgggtggtga tgcccatgac ccggggcccg
    16441 ctgctcaccg tcggactcac caccacggtg tgggcctgga aggactacct gtggccgctg
    16501 ctgtccggcc gggacgagga gacgcgggta ctcaccgtcg ccctcggcat cttccagcag
    16561 cagtcgccca acacccagcc cgactggacc ggactgatgg cggggtccgc cctctccgtg
    16621 ctgcccgtgc tcgtcctcct gatcctcctc ggccgccggc tcgtcgagtc cctgaacttc
    16681 accggcatga agtgacccgc ccccgcggag ccaccgcccg cccccaccga tcccgtacga
    16741 gccaggaagg cccctcgcga tgagaccccg acacctgcgc gccggcgcgg ccctgctgtg
    16801 tctgactgcc ctcaccactc tcgtctcctg cggcagctcc gacgaggcgg gcgacgggcg
    16861 gaccaccgtc gactactggc tgtgggacga cctccagctc cccgcctacc aggagtgcgc
    16921 gaccgccttc gagaaggcca acccggacat cgcggtcagg atcacgcaga ccgcgtggaa
    16981 ccagtactgg cagaacctca ccacgcaact ggtctccggc gaggcgcccg acgtgtggac
    17041 caaccaggcc acctactatc cgcagttcgc cgccggcaac cagctcctgg acctccagcc
    17101 ctacgtggag cgggacgggc tcgacgtctc cgcctaccag gcgggcctcg ccgacacctg
    17161 ggtgaaggac gacaagcgct acggcctgcc caaggactgg gacaccatgg ccgtcgtcta
    17221 caacaccgac atgctgaaga ggcagggcgt ggacctcgcc gccctgaacg acctgacgtg
    17281 gaacccggcg gacggcggca ccctggagca ggtgatcgcc agggccacgg tggacagcga
    17341 gggccgcaac ggtctcgacc ccgccttcga caaggaccac gtggaggtct acggcttcct
    17401 gcccgaatgg gccgacggcg cccagggcca gaacggctgg ggcaacttcg ccgccgccaa
    17461 cgggttcgag tacctcgaca agaacccctg gggcacgcac tacaagttcg acgaccccag
    17521 actcgccgag accgtctcgt ggttccggca cctgatcgac aagggctacg cgccccgcct
    17581 cgaccagcag tcgagcgtgg ccaggaccga actgctcatc gccgggaagg gcgccatgtc
    17641 gctcgcgggc tccttcaccg tctccagctt caccgggccc aaggtcaagc aggacttcgg
    17701 gttcgcggcg atgccggtcg gcccggccgg ccgcaagagc gccctcaacg gcctcgcgga
    17761 ctccgtctgg gccggcacgg accacaagga ggaggcgtgg aagtgggtca agtacctcgc
    17821 gtcggccgac tgccaggacc gggtcgccgc gcacggtgtc gtctttcccg cgctgaagag
    17881 ttccaccgag aaggccctcg ccgcacacga ggccgacggt gacgacgtgc gcgccttcac
    17941 cgacgccgtc gggacgaagg gcgtcacctt ccagcttccc gtcaccgagc acggcaccga
    18001 gatcagtcct ctcgtgcagg acgccatcca gtcggcgatc ctcggccagg aggacgccgc
    18061 cgatgccctg gagtcggtca acggcaaggt gaacggcctc ttcgactagg gggtgcccac
    18121 cgcgtacgcg caggcctccc cgtaccgcac gcacccctgt ccctgtccgc accgcggagt
    18181 ccatccgtac cgcaagcccc acccgtaccg caggtaccgc aacgcaagga gacccatggc
    18241 ccagctcgta gaactcggcg ggcgcaccct cgccgtcgag ctcgcaggcg acgcgccgcc
    18301 ccgagccgtg gaaggcggtc tgctgctgcc acccggccgg acggccgtgc tccacggtct
    18361 cagggacgcg ctcttctacc gccacggcca caactcgtgg agcccgtgcg gctggcgccg
    18421 gctctccgag gcgccgctgc ggatcgagag cgccgaacgc cgtctgaccg ccgacgacac
    18481 cgtgtgggac gatcccgccc gccaccactc gtcggccgtc gccgccctgg aggggccgga
    18541 cgggcgggtg ctgctgctcg gcgcgctcgg cctcgacgtc ccccgcctga ccgccgaccg
    18601 ggacaccctc accgggtggt gcgagcgcga cggagcgccc tggttcctcg ccctcggcag
    18661 cgaggaggag gtgttcgccg cctacgcgcg gcacctcggc gaccggctcg ggcgcagcga
    18721 caagcgggcg ggcaacgtgt ggtgcagctg gtacgcgtac tacgagagca tcaccgagga
    18781 gcagctcacc aaggacgtca cggcgctgcg cggcctgccc ttcgacgtcg tccaggtcga
    18841 cgacggctgg gagcgggcgg tgggcgactg ggaggccaac gacaagttcc cgtccgggat
    18901 gcgggcgctg gccgaccgga tcacggacgc cgggctgcgg cccggactgt ggatcgcccc
    18961 gttcatcgtc ctgcccggct cccgtaccgc ccggcagcgg ccggagctgc tgctgcgcga
    19021 cgggcgcggc gagccggtgg tcgccgggca caactggggc gtcggctact ggacgctcga
    19081 cctcacgctg cccgcggcgc aggagcacct gcgcgagacg atccgccggg tcgtccggga
    19141 gtgggggttc acctacctca agctcgactt cgtcggcgcc ggcgccgtgc ccggagtgcg
    19201 tttcgccgac gtgggccgcg aggaggccta ccgcaccggc ctctcgatcg tccgggaggc
    19261 ggcgggcccg gacgcctacc tcctcggcag cggcgccccg ctgctgccct cgctggggct
    19321 ggtcgacgcc atccgcagcg gccccgacgt cgcgccgatg tgggagcact acgccaccca
    19381 ggacccgtcc gacgcgctgg cccgcaacgc cgtcgtcaac acggtgcacc ggttgtggca
    19441 gtcaccgctg ctggaggtcg acccggacgt cgtgtacttc cgcagccgcc tgaacctgct
    19501 gaccgagcag cagcaggggc tgctgcgcga cctggccgac gtgtgcggtt tccgggccgt
    19561 atccgacccg ccgggatggc tgctcccgga ggaactgaag gcgatggagg cgtacttgac
    19621 cggccgcccg gaggtgcgcc ggctcgggcg ctaccgcttc gcgctcgacg gccgggaggt
    19681 ggacttcggc gcggccgtga cccccggcga cgagcagcgc tatcccctcg cctgacctcg
    19741 tacccgcacg cggccaccgc cacgaattag taaactcttc agcaatattc ggcggtggcc
    19801 accgcaacgc ctccagggag caccaacatg gcgacgaccg gaacggacat gtcccggatg
    19861 cgtgagatga accagctgtc catcgtggga gcactgcgcg gcaacccgcc ctccacggtc
    19921 accgagctgg cgtcccgctc cggcctgtcc cgtcccgcgg tggacgtgct ggtgcagtcc
    19981 ctggtcgccg acggctgggc ggaggtggag gagccggggg ccagcagtgt ggtggggcgt
    20041 cccgcgcgcc ggtaccggtt cagggccacc gccgggcacg tgctgggcat cgacatcggc
    20101 gtgcacaaga tcctcgtgat cctcagcgat ctggagggga acctggtgcg cacggtgcgc
    20161 cacccggccg ccccggaggc ggcgcccgcc gagcggctgg cggcggtgga ccgggtcgtc
    20221 gacgaggtgc tggcgagcgc gggcatggcc gcgggcgaca tctgggccgt gaccgtcggg
    20281 gtgaccggtc cggtcgaccg cagcggccgg acctcgctgt ccagcccgct gcccggctgg
    20341 agcgaggccg acccggccgc ccacctcggc acccggttct cctgccccgt acaggtggag
    20401 aacgactgca agctggccgc cgtcgccgaa cggtggcggg gcgtcgcgca ggacgccgac
    20461 gacatcgtgt acctcctcgc cggtctgcgc accggcgccg gtctcatcct cgacggcacc
    20521 ctgcgccggg gccacggcgg cgccgcggga gagatcggcg cgctcaaggc cgtacggtgg
    20581 ctcaccgcgc ccgaccacct gcagtcctgc cccgggatgc cggcgaccgc cgcggagggc
    20641 gaggcggcgg cctgggtctt ccaggccgcc cgggacggcg accgggacgc ccggacggcc
    20701 gtccggcgct acacccgcga cctcgcggtg ggggtggccg ccctggtcct cgccctggac
    20761 ccgcaggtcg tcgtctacgg cggcgggttc tcccggtccg ccgacgtggt cctcggtccc
    20821 ctgcaccgcg agctgaccaa gcactgtctg cggatgccgg agctgcgcgc ctccacgctc
    20881 ggcgacgaga gcgtggcgct gggggcggtg cggctggccc tggacgaggt cgacagccgg
    20941 ctgctgagcg acggtctggc ggcgccgacc gcaccccggc ggtaacgaca gggccgggca
    21001 cgcacccggc gctcgtacgc aacaccaaca cccgacagga acgaagggac agcccagtga
    21061 gcacccgtga ccagataccg gaccggcacc tgcgcgtcgg cgtcgtcggc gtcggacagc
    21121 gcgcggacat ggccgcgctg gtgaaccgtt ccggcgctgc ccggatcgtg tcctgcgccg
    21181 acccggaccc gcggggccgg gaggacgcca ggcgtctgtt cggcgcggac gtcgtggtgc
    21241 acgaccggta cgagcggatg ctcgacgacg agctggacgc cgtgttcgtc ctcacccccg
    21301 accacctgca caccgaaccc gcgctgtgct tcctcgcggc gggcgtggcg gtgttcgtgg
    21361 agaagccgct gaccatcacg gtcgccgact gcgacgcgct gctcatggcg gcgttccgct
    21421 cccgcacccg gctctacgtg ggccacaacc tgcgtcacct tcccgtgctg cgccggatgc
    21481 gcgagctgat cgacgacggc gcggtcggcc gcgtccgcgc ggtgtggtgc cgccacttcg
    21541 tcggccacgg cggggacttc tacttcaagg actggcacgc gcagcgggcg aacaccaccg
    21601 gtctgctgct gcagaagggc gcccacgacc tcgacgtcgt ccactggctc gccgggggct
    21661 tctcccgcaa cgtggtcgcc cagggtgcgc tggccgtcta tggcgacaac ccgcgccggg
    21721 ccacgcagga gacggtgccg cccggtcagc gcatgcccga ctggttcgac ccggaggtct
    21781 ggccgccgtc cgccctgcgc gacctcaacc ccgtcgtcga cgtcgaggac atcagcatga
    21841 tgctggcccg cctggacaac ggcgtcctcg ccagctacca gcagtgccac ttcacgcccg
    21901 actactggcg caactacacc gtcatcggcg acgagggccg cctggagaac ttcggcgacg
    21961 gcatcgacgg cgatgccgca cgggtcgacg tgtggaaccg gcgccgctcc ggctaccgtg
    22021 ccgacgccga cctctccgtt ccggtcgtgg cgtccgacga ggagacgcac ggcggcgcgg
    22081 accgggcgct cgtcgaggag ttcctgcgct tcgccgccgc cggaggcccg accgagacct
    22141 cacccgtggc cgcccgcgag gcggtcgccg ccgcggtcgc cgccacgacc tcgctgcgct
    22201 ccggcagtac accggtcgac gttcccccgc tcgacccggc gatcgtccgc cacttcgcgg
    22261 agcaccagcc cgccgagggg gccgacggga gcggtccgca gccccggtga cagtggcggc
    22321 gggatctggc ccaccgaccg ccggtcggtc gcgtccgcgc cgctgcgtcg cctcctggcc
    22381 gaccggccgg ccgagtgctc ggcgcgggac tgcgccgacg gctgaagagc gagctgccgg
    22441 ttcctgccac ggtggtgctt cggccggcgt cagcggctcg ctcgggccgg gtcacgggtg
    22501 gaagcgccac cggccttcgg aaacgacatc cgccttgccg tccctgacac gcaccgccgt
    22561 ctcgtcgtcg atgaagtaga tcgggaagtc cgcccgcgcg gtgatccggt cggcccaggc
    22621 gtcgtcccgc tcggggaagt cgggcgagta gaggtggggc ttgaggtacc agtcgaagag
    22681 accgaacggc ggctccacgc tcgtcgcacc gagcacgtgg aggtccgtgg cgtccccgat
    22741 gacgtcggcg gagtgtccgg tgagattgcg gctgaagatc atcgacccgg cgctgacccc
    22801 cacgtagaca cggctctgca acgcctccag gaagccgtcg gccaggccgt tgccggtgat
    22861 gctgcgcgcg aggtgatagt ggttgccgcc ttcgacgtag acgacgtcgg cgtggagcag
    22921 ccggtcgagc accatctgct ggggcaggcc gttcagctca aggatgtcga actcccgcca
    22981 gccgaggccg tgcaggcggt tcatgtccgc gacgacccac ccgtggtccc cggggtccgc
    23041 gacggatgcc gtgggaacga acacgacgtt cgccgatccg aacggtttgc ccagcatgtc
    23101 ccgcagcgca tcccgcagtg tctcgttgcg caggccgctc gccgtcagca ggaagttcat
    23161 cggacgagcc aagcacggct gacgggcggc acgcaaacca tccccgagcc cgcacgaacg
    23221 cgcggttgtc agtggcccct gccaggatgc gccgatgacc tcaagcgacc acccgctcag
    23281 ggcgtccctc gacgagccgc gggcccacct cctcgatctg atcggtgctg tcgagccgtg
    23341 ggacgacctg gagcacaccc atctggagtc cgccaggcac tggatcgccg gcggcgcccc
    23401 tctctaccgg gtgcgcaagc cggacgttcc gcccatgcac ctggtgagct acttcgccgt
    23461 cctcgacgac acgcgcgggc aactcctgct cgtggcgcac cgcaaggcgg ggctgtggct
    23521 gcctgccgga ggacacgtcg agtcgggtga ggacccgtgg gccgcggtgg tccgcgagtg
    23581 ccgtgaggag ctgggcatcg aggcggtggc gtcgcccgtc gcgggtgagc ttccgttctt
    23641 cctgaccgtc accggaaccc gggggcaggg cccgcacacc gacgtctcgc tgtggtacct
    23701 cctcgatgcc gacgcccaca ccgtcaccga ttacgaccgg ggcgagttca gcgccgtccg
    23761 ctggctgacg cacgagcagg ttctcgccgc gtcggccgaa ctgctcgacc cccacatgca
    23821 ccgcttcgct cggaagctgg cgtgggcgcg ggcgggtcgg ggcgggtgag aattgcggcg
    23881 tcccctgctc gagagcggcg gctgtttgtc ggcacgtgtc caccccgagt ccccgaggac
    23941 ggtccaccat gaccatgcag ccctggttca acgaggcgaa gctgggcata ttcgtgcact
    24001 acggcatcta ctcggtcgac ggagtacccg agtcctgggc ccttttcgac caggtggtgc
    24061 cgcacgagca gtacatgcgc caactcgacg gcttcaccgc cgccgccttc gatccctccg
    24121 cttgggccgg gctcttcgcg cgcgccgggg ccggctacgc cgtgctgacg gcacggcacc
    24181 acgacggagt ggccctgtgg gaaacgcggt tgagcgacct gagcgtggtc gggcgtaccc
    24241 ccgcgggacg cgacctggtt gccgagtacg tgagcgcgat gcgcgaccgg ggcctcaggg
    24301 ccggtctgta ctactcgcac tccgactgga accatccgga ctacgcatcg gtacggcacc
    24361 cccggccacc gcatcccgaa ctggtcgaca gcccctacgt ctcccccgcc ccgggcgccg
    24421 aggacccgcg ggcctgggag cgctacctcg actaccggga cggccaggtg cgcgagctgc
    24481 tcacccggtt cggaccggat ctgctctggt tcgacggcga gtgggagcgc tcggccgagc
    24541 agtggcggat gtccgaact
//
