LOCUS       NZ_BMVL01000034        13949 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence34, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000034
VERSION     NZ_BMVL01000034.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 13949)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 13949
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..13949
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     gene            complement(<1..1903)
                     /locus_tag="IE257_RS37385"
     CDS             complement(<1..1903)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (1-300). E-value:
                     1.4e-115. Score: 377.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS37385_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE257_RS37385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_189974524.1"
                     /sec_met_domain="Condensation (E-value: 3.4e-68, bitscore:
                     217.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.7e-39, bitscore:
                     121.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFPLSFAQRRLWFLSQLEGPSATYNIPIARRLAGRIDGDALNTAL
                     RDVLGRHEVLRTVYPTVAGEPLQDILKLEDLDWSLTVTDVNPAELDVTVAELEAHTFDL
                     ATEVPIRASLLRTGPEEQVLVLVVHHIATDGWSMGPLLRDVTSAYTARAEGRAPEWEPL
                     PVQYADYTLWQRELLGDEQDPDSLMARQIAYWRANLTGAPEELSLPFDHTRPAIASHRG
                     HGVPLEIPAAVHARLAEVARAEDATVFMVLQAALAVVLSRLGAGTDIPIGTAVAGRTDV
                     ALDDVIGFFVNTLVLRADLSGDPTFKELLARVRQTGWAALAQQDVPFEKLVEELAPTRS
                     LARHPLVQVMLTVHNNERIVLERSGAESEGSAADAVVDVRAAKFDLELDFVELFDQGGA
                     PAGLQGSVTASVDLFGRDTVARLATQVRRALELLVAEPETRLSGVDLLDAAERRQVLVD
                     WNDTAVEVGSSSLPGLFEAQVGRTPGAVAVVFEGVEHSYAELDGRANRLARLLVSRGVG
                     AESVVGVALERGVDMVVALLAVVKAGGAYLPIDPEYPSERVAFVLEDAAPVVVVTSQAV
                     AGVVPSGVPVVVVDEPAVVDELAGVADGPLGVRVLPSHPAYVIFTSGSTGRPKGVVVP"
     source          1..13949
                     /culture_collection="JCM:4726"
                     /db_xref="taxon:1895"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces avidinii"
                     /strain="JCM 4726"
                     /submitter_seqid="sequence34"
                     /type_material="type strain of Streptomyces avidinii"
     cand_cluster    1..13949
                     /SMILES="NC(C(O)C)C(=O)NCC(=O)NC(CO)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13949
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:>13949](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..>13949)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS_motif       complement(5..58)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0008"
                     /evalue="6.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE257_RS37385"
                     /protein_end="633"
                     /protein_start="615"
                     /score="31.0"
                     /tool="antismash"
                     /translation="AYVIFTSGSTGRPKGVVV"
     CDS_motif       complement(254..295)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0007"
                     /evalue="2.40E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE257_RS37385"
                     /protein_end="550"
                     /protein_start="536"
                     /score="17.5"
                     /tool="antismash"
                     /translation="LAVVKAGGAYLPID"
     CDS_motif       complement(848..964)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0006"
                     /evalue="1.70E-18"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE257_RS37385"
                     /protein_end="352"
                     /protein_start="313"
                     /score="59.0"
                     /tool="antismash"
                     /translation="RQTGWAALAQQDVPFEKLVEELAPTRSLARHPLVQVMLT"
     aSDomain        complement(1004..1900)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37385_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.40E-115"
                     /label="IE257_RS37385_Condensation_LCL.1"
                     /locus_tag="IE257_RS37385"
                     /protein_end="300"
                     /protein_start="1"
                     /score="377.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIATDG"
                     /tool="antismash"
                     /translation="FPLSFAQRRLWFLSQLEGPSATYNIPIARRLAGRIDGDALNTALR
                     DVLGRHEVLRTVYPTVAGEPLQDILKLEDLDWSLTVTDVNPAELDVTVAELEAHTFDLA
                     TEVPIRASLLRTGPEEQVLVLVVHHIATDGWSMGPLLRDVTSAYTARAEGRAPEWEPLP
                     VQYADYTLWQRELLGDEQDPDSLMARQIAYWRANLTGAPEELSLPFDHTRPAIASHRGH
                     GVPLEIPAAVHARLAEVARAEDATVFMVLQAALAVVLSRLGAGTDIPIGTAVAGRTDVA
                     LDDVIGFFVNTLVLRADL"
     CDS_motif       complement(1013..1102)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0005"
                     /evalue="5.90E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE257_RS37385"
                     /protein_end="297"
                     /protein_start="267"
                     /score="44.4"
                     /tool="antismash"
                     /translation="DIPIGTAVAGRTDVALDDVIGFFVNTLVLR"
     CDS_motif       complement(1370..1408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0004"
                     /evalue="6.50E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE257_RS37385"
                     /protein_end="178"
                     /protein_start="165"
                     /score="18.6"
                     /tool="antismash"
                     /translation="QYADYTLWQRELL"
     CDS_motif       complement(1457..1522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0003"
                     /evalue="1.50E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE257_RS37385"
                     /protein_end="149"
                     /protein_start="127"
                     /score="36.6"
                     /tool="antismash"
                     /translation="VHHIATDGWSMGPLLRDVTSAY"
     CDS_motif       complement(1724..1840)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0002"
                     /evalue="1.70E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE257_RS37385"
                     /protein_end="60"
                     /protein_start="21"
                     /score="46.1"
                     /tool="antismash"
                     /translation="ATYNIPIARRLAGRIDGDALNTALRDVLGRHEVLRTVYP"
     CDS_motif       complement(1862..1891)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37385_0001"
                     /evalue="2.70E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE257_RS37385"
                     /protein_end="14"
                     /protein_start="4"
                     /score="10.3"
                     /tool="antismash"
                     /translation="SFAQRRLWFL"
     gene            complement(1903..10332)
                     /locus_tag="IE257_RS37390"
                     /old_locus_tag="GCM10010343_76350"
     CDS             complement(1903..10332)
                     /NRPS_PKS="Domain: Condensation_LCL (1-300). E-value:
                     6.4e-114. Score: 371.9. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_Condensation_LCL.1"
                     /NRPS_PKS="Domain: PCP (546-612). E-value: 7.8e-25. Score:
                     78.9. Matches aSDomain: nrpspksdomains_IE257_RS37390_PCP.1"
                     /NRPS_PKS="Domain: Condensation_Dual (660-951). E-value:
                     2.3e-106. Score: 347.4. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_Condensation_Dual.1"
                     /NRPS_PKS="Domain: AMP-binding (1128-1524). E-value:
                     3.5e-109. Score: 357.1. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1632-1694). E-value: 7.8e-26.
                     Score: 82.1. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_PCP.2"
                     /NRPS_PKS="Domain: Condensation_Dual (1746-2036). E-value:
                     3.3e-114. Score: 373.1. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_Condensation_Dual.2"
                     /NRPS_PKS="Domain: AMP-binding (2214-2615). E-value:
                     2.1e-110. Score: 361.1. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2724-2792). E-value: 7.4e-28.
                     Score: 88.6. Matches aSDomain:
                     nrpspksdomains_IE257_RS37390_PCP.3"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF003417.0"
                     /locus_tag="IE257_RS37390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_76350"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_189974535.1"
                     /sec_met_domain="Condensation (E-value: 4.3e-69, bitscore:
                     220.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 7.8e-119, bitscore:
                     384.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.3e-19, bitscore:
                     56.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIALSFAQRRLWFISQLEGPSATYNVPMVLPLGAQIDRAALNTAL
                     RDVIGRHEVLRTVFVTVDGEPYQDVRKIDDLAWELSVTEVAPAELSAAIAAAEGYAFDL
                     AAEVPVRAELLVASPDEQVLVVVLHHIASDGWSMGPLTRDLMTAYQARSEGREPQWEPL
                     PVQYADYALWQRDLMGDADDPTSLMHRQLGYWRDALAGLPDGIALPFDRPRPAAASYRG
                     HRVRLELAAPTHARLLQLAQDEGVTVFMTLQAVLAVLLSRLGAGTDIAVGTDVAGRSDE
                     ALDDLVGFFVNTLVLRTDLSGDPTFRETLGRVRATTLGAFGHQDLPFDRLVEDLAPARS
                     LSRHPLFQVMLTLQNAARTVRDEESVAVSAVTPDGATQAKFDLELSFTEVYGPDGLPSG
                     IQGSVTAAADLFDEGTALLFADCLTRALDTLTGAPELPLSGVRIVDGSGAEAVFPGRVS
                     TGAAAAGPAAEAVDRRLVAYVVPAPGMEIDPSELRAFVREQLPDSMVPAAVVLLDELPL
                     TANGKVDTGKLPAPPTYPVAAGRGPANAREEVLCAAFAEVLELDRVGAEDDFFALGGHS
                     LLAIRLVERLRAQGVTVPVRALFETPTPAGLALTAGARRPDAPENLIPAGATEITPEML
                     PLVTLTAEELARVVATVDGGAPNIADVYPLGPLQEGLLFHHLMAEGGDDAYVMPAVMEF
                     ASRTGLDTFLAAFQNVLDRHDIFRTSFVWEGLPDPVQVVWRRAAMPVTDVTLPADAEDP
                     VTDLIAAVGLSMDLGRAPLITVHRAAVPGADRWMALVRVHHLVQDHMALELLLSEVRAF
                     LTGRGADLPEPMPFRNFVAQARQEAEGSGQREYFAELLGDFDEPSAPYGVTDVHGDGTA
                     VSRGVVPFAPESERRLREVARRLRVSAATVLHVAWARTVGAMSGRDDVVFGTVLFGRMS
                     GGAEAGQVPGPFINTLPVRVRTSDTGVLTAVSDMRTQLARLLEHEHASLATAQQASGLQ
                     GEAPLFTAFLNYRHNAGRGEEQAEREPAADEHPDDLDARLLYARERTNYPLGVAVDDDG
                     EGVGLALTVDAVGPIDPEAVGLLVRTATEELVQALETALDGGPEAPLGAVRVLDEAGLH
                     RVVEEWNDTEAETGAATLPGLFEAQAARTPDAIALVQGDVELGYAELDARVSRLARLLR
                     GRGVGPESVVGVVMDRGVDLVVALLAVMKAGGAYLPVDPEYPAERIAYVLADAGVPLVL
                     SHTAVADVVPAGVPVVVVDDPSVVAELAVLSDVPDVPVRGGVELESCNAAYVIYTSGST
                     GRPKGVVIPHGALVNHLFAAGERVGVAAGDRLVAVTTVSFDIAALELFLPLVSGASVVL
                     ASRETVRDPAALAELVCSSGANVLQAVPSLWRALLEEEGWPVGVRALVGGEALPRELAQ
                     RFTDLGVRAVNLYGPTEATVWATSAEVASDVVSVGRPFANVRAYVLDRSMRPAPVGVAG
                     ELYLAGAQLARGYVGRSGLTAERFVASPYGFGERLYRTGDLARWRADGELECLGRADDQ
                     VKVRGFRIELGEVEAVLERHEGVARAVAAVRRDTSGDALLAAYVVADGGLAPDVAALRV
                     HLLQDLPAYMVPSAFVVLDELPLTANGKVDRKALPAPDVTAGSGGGRGPSNSREEILCA
                     AFAEVLGLESVGVDDDFFALGGHSLLAVRLIGRVQAQGVALSVRALFDSPTPAGLALSE
                     GLRPAHVPDNLIPADATAITPEMLTLVELSGEEIDRVAATVAGGAANIADIYPLAPLQE
                     GLLFHHLLADGGDDVYVQPNVLEFGSRELLDRFAEALQLVLDRHDILRTGIVWDGLREP
                     VQVVWRKAELPVREVTLDPRGTDLATELAEAVGLSMDLSRAPLVELHTTEGPEGRWLGL
                     VRIHHMVQDHTALEVLLGEIAAFLTGHGDELPQPLPFRDFVAQARGGVPREEHERYFAA
                     LLGDVTEPTAPYGLTDVRGAGTGTERATGELDPALNERLRVVSRRLGASVATVMHVAWA
                     RVLGAISGRDDVVFGTVLFGRMNAGAGGDRVPGPFINTLPLRVRTDGPDVVDAVSTMRS
                     QLARLLEHEHASLALAQQSSGITAGSPLFTSFLNYRHTQDPSDGPSMTAAPADNGHGEA
                     EPPAIQTLLSKETTNYPLAVAVNDSGRSIRMAVEAVAPADPAEVQALLCTAVDGLVSAL
                     ERALDGGAQTPLRSVPVLDEAGLDRVVRDWNDTAVEVGSSSLSGLFEAQVGRTPGAVAV
                     VFEGVEVSYAELDGRANRLARLLVARGVGAESVVGVALERGVDMVVALLAVVKAGGAYL
                     PIEPGLPADRTAYMVETAGAGVVVSSSAVAGGLAVDVPLVILDEPAVVRELAGLSGEQL
                     GVEVASEGAAYVIFTSGSTGRPKGVVVSHEGIVNRLAWMQARFGIGGADRVLQKTPFGF
                     DVSVWEFFWPLSVGAALVVARPGGHKDPAYLAGVVCGQRVTVAHFVPSMLEAFLADESA
                     MDTAGVLRYVVCSGEALSASVRDRFFGVLAGVELHNLYGPTEASVDVTAWECEPGADGA
                     VVPIGAPVANTRVYVLDARLAPVPVGVAGELYLAGVQLARGYANRPGLTAERFVASPYG
                     TGERLYRTGDIARWTADGQVEYLGRADEQVKVRGFRIEPGEVQAVIAAHPQVAQAAVIA
                     REDVPGDKRLVAYVVPIPGGIEADELAFTVVDVASDHLPAHMVPSAVVVLDALPLSVNG
                     KLDRKALPAPEYTAGAGRGPADAREEILCTLFAEVLGLESVGVDDDFFELGGHSLLAVR
                     LTSRIRAALGIEAPLQALLQAPTVAGLAQQLGNEKSARPSLRSMRNQEES"
     aSDomain        complement(1957..2160)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_PCP.3"
                     /evalue="7.40E-28"
                     /label="IE257_RS37390_PCP.3"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2792"
                     /protein_start="2724"
                     /score="88.6"
                     /tool="antismash"
                     /translation="EEILCTLFAEVLGLESVGVDDDFFELGGHSLLAVRLTSRIRAALG
                     IEAPLQALLQAPTVAGLAQQLGN"
     aSModule        complement(1957..5094)
                     /complete
                     /domains="nrpspksdomains_IE257_RS37390_Condensation_Dual.2"
                     /domains="nrpspksdomains_IE257_RS37390_AMP-binding.2"
                     /domains="nrpspksdomains_IE257_RS37390_PCP.3"
                     /locus_tags="IE257_RS37390"
                     /monomer_pairings="Ser -> Ser"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2122..2154)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0032"
                     /evalue="5.00E-02"
                     /label="Cy4"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2737"
                     /protein_start="2726"
                     /score="6.9"
                     /tool="antismash"
                     /translation="ILCTLFAEVLG"
     CDS_motif       complement(2209..2235)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0031"
                     /evalue="2.40E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2708"
                     /protein_start="2699"
                     /score="4.7"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     CDS_motif       complement(2461..2523)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0030"
                     /evalue="4.30E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2624"
                     /protein_start="2603"
                     /score="34.8"
                     /tool="antismash"
                     /translation="YLGRADEQVKVRGFRIEPGEV"
     aSDomain        complement(2488..3690)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_AMP-binding.2"
                     /evalue="2.10E-110"
                     /label="IE257_RS37390_AMP-binding.2"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2615"
                     /protein_start="2214"
                     /score="361.1"
                     /specificity="substrate consensus: Ser"
                     /tool="antismash"
                     /translation="FEAQVGRTPGAVAVVFEGVEVSYAELDGRANRLARLLVARGVGAE
                     SVVGVALERGVDMVVALLAVVKAGGAYLPIEPGLPADRTAYMVETAGAGVVVSSSAVAG
                     GLAVDVPLVILDEPAVVRELAGLSGEQLGVEVASEGAAYVIFTSGSTGRPKGVVVSHEG
                     IVNRLAWMQARFGIGGADRVLQKTPFGFDVSVWEFFWPLSVGAALVVARPGGHKDPAYL
                     AGVVCGQRVTVAHFVPSMLEAFLADESAMDTAGVLRYVVCSGEALSASVRDRFFGVLAG
                     VELHNLYGPTEASVDVTAWECEPGADGAVVPIGAPVANTRVYVLDARLAPVPVGVAGEL
                     YLAGVQLARGYANRPGLTAERFVASPYGTGERLYRTGDIARWTADGQVEYLGRADEQVK
                     VR"
     CDS_motif       complement(2605..2694)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0029"
                     /evalue="3.40E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2576"
                     /protein_start="2546"
                     /score="51.3"
                     /tool="antismash"
                     /translation="PVGVAGELYLAGVQLARGYANRPGLTAERF"
     CDS_motif       complement(2806..2829)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0028"
                     /evalue="5.20E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2509"
                     /protein_start="2501"
                     /score="3.9"
                     /tool="antismash"
                     /translation="YGPTEASV"
     CDS_motif       complement(3208..3267)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0027"
                     /evalue="1.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2375"
                     /protein_start="2355"
                     /score="33.3"
                     /tool="antismash"
                     /translation="AYVIFTSGSTGRPKGVVVSH"
     CDS_motif       complement(3466..3504)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0026"
                     /evalue="7.30E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2289"
                     /protein_start="2276"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LAVVKAGGAYLPI"
     CDS_motif       complement(4108..4176)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0025"
                     /evalue="2.60E-06"
                     /label="C67_dual_14fromHMM"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2075"
                     /protein_start="2052"
                     /score="20.1"
                     /tool="antismash"
                     /translation="LARLLEHEHASLALAQQSSGITA"
     aSDomain        complement(4225..5094)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_Condensation_Dual.
                     2"
                     /domain_subtypes="Condensation_Dual"
                     /evalue="3.30E-114"
                     /label="IE257_RS37390_Condensation_Dual.2"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2036"
                     /protein_start="1746"
                     /score="373.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHMVQDH"
                     /tool="antismash"
                     /translation="DIYPLAPLQEGLLFHHLLADGGDDVYVQPNVLEFGSRELLDRFAE
                     ALQLVLDRHDILRTGIVWDGLREPVQVVWRKAELPVREVTLDPRGTDLATELAEAVGLS
                     MDLSRAPLVELHTTEGPEGRWLGLVRIHHMVQDHTALEVLLGEIAAFLTGHGDELPQPL
                     PFRDFVAQARGGVPREEHERYFAALLGDVTEPTAPYGLTDVRGAGTGTERATGELDPAL
                     NERLRVVSRRLGASVATVMHVAWARVLGAISGRDDVVFGTVLFGRMNAGAGGDRVPGPF
                     INTLPLRVR"
     CDS_motif       complement(4231..4326)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0024"
                     /evalue="2.10E-13"
                     /label="C5_dual_260-291"
                     /locus_tag="IE257_RS37390"
                     /protein_end="2034"
                     /protein_start="2002"
                     /score="42.6"
                     /tool="antismash"
                     /translation="DVVFGTVLFGRMNAGAGGDRVPGPFINTLPLR"
     CDS_motif       complement(4336..4383)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0023"
                     /evalue="2.90E+01"
                     /label="Cy4"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1999"
                     /protein_start="1983"
                     /score="-1.8"
                     /tool="antismash"
                     /translation="ATVMHVAWARVLGAIS"
     CDS_motif       complement(4567..4605)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0022"
                     /evalue="2.00E-04"
                     /label="C4_dual_169-182"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1922"
                     /protein_start="1909"
                     /score="14.2"
                     /tool="antismash"
                     /translation="PFRDFVAQARGGV"
     CDS_motif       complement(4639..4701)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0021"
                     /evalue="1.60E-06"
                     /label="C3_dual_135-156"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1898"
                     /protein_start="1877"
                     /score="21.0"
                     /tool="antismash"
                     /translation="HHMVQDHTALEVLLGEIAAFL"
     CDS_motif       complement(4906..5019)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0020"
                     /evalue="1.50E-16"
                     /label="C2_dual_024-063"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1809"
                     /protein_start="1771"
                     /score="52.9"
                     /tool="antismash"
                     /translation="YVQPNVLEFGSRELLDRFAEALQLVLDRHDILRTGIVW"
     CDS_motif       complement(5047..5088)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0019"
                     /evalue="1.80E-06"
                     /label="C1_dual_004-017"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1762"
                     /protein_start="1748"
                     /score="20.3"
                     /tool="antismash"
                     /translation="YPLAPLQEGLLFHH"
     aSDomain        complement(5251..5436)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_PCP.2"
                     /evalue="7.80E-26"
                     /label="IE257_RS37390_PCP.2"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1694"
                     /protein_start="1632"
                     /score="82.1"
                     /tool="antismash"
                     /translation="EEILCAAFAEVLGLESVGVDDDFFALGGHSLLAVRLIGRVQAQGV
                     ALSVRALFDSPTPAGLA"
     aSModule        complement(5251..8352)
                     /complete
                     /domains="nrpspksdomains_IE257_RS37390_Condensation_Dual.1"
                     /domains="nrpspksdomains_IE257_RS37390_AMP-binding.1"
                     /domains="nrpspksdomains_IE257_RS37390_PCP.2"
                     /locus_tags="IE257_RS37390"
                     /monomer_pairings="Gly -> Gly"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(5398..5430)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0018"
                     /evalue="7.20E-03"
                     /label="Cy4"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1645"
                     /protein_start="1634"
                     /score="9.5"
                     /tool="antismash"
                     /translation="ILCAAFAEVLG"
     CDS_motif       complement(5491..5517)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0017"
                     /evalue="1.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1614"
                     /protein_start="1605"
                     /score="5.0"
                     /tool="antismash"
                     /translation="GKVDRKALP"
     CDS_motif       complement(5731..5796)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0016"
                     /evalue="4.80E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1534"
                     /protein_start="1512"
                     /score="37.8"
                     /tool="antismash"
                     /translation="CLGRADDQVKVRGFRIELGEVE"
     aSDomain        complement(5761..6948)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_AMP-binding.1"
                     /evalue="3.50E-109"
                     /label="IE257_RS37390_AMP-binding.1"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1524"
                     /protein_start="1128"
                     /score="357.1"
                     /specificity="substrate consensus: Gly"
                     /tool="antismash"
                     /translation="FEAQAARTPDAIALVQGDVELGYAELDARVSRLARLLRGRGVGPE
                     SVVGVVMDRGVDLVVALLAVMKAGGAYLPVDPEYPAERIAYVLADAGVPLVLSHTAVAD
                     VVPAGVPVVVVDDPSVVAELAVLSDVPDVPVRGGVELESCNAAYVIYTSGSTGRPKGVV
                     IPHGALVNHLFAAGERVGVAAGDRLVAVTTVSFDIAALELFLPLVSGASVVLASRETVR
                     DPAALAELVCSSGANVLQAVPSLWRALLEEEGWPVGVRALVGGEALPRELAQRFTDLGV
                     RAVNLYGPTEATVWATSAEVASDVVSVGRPFANVRAYVLDRSMRPAPVGVAGELYLAGA
                     QLARGYVGRSGLTAERFVASPYGFGERLYRTGDLARWRADGELECLGRADDQVKVR"
     CDS_motif       complement(5878..5967)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0015"
                     /evalue="3.70E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1485"
                     /protein_start="1455"
                     /score="48.0"
                     /tool="antismash"
                     /translation="PVGVAGELYLAGAQLARGYVGRSGLTAERF"
     CDS_motif       complement(6067..6090)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0014"
                     /evalue="1.50E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1422"
                     /protein_start="1414"
                     /score="5.4"
                     /tool="antismash"
                     /translation="YGPTEATV"
     CDS_motif       complement(6451..6510)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0013"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1294"
                     /protein_start="1274"
                     /score="32.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVIPH"
     CDS_motif       complement(6721..6762)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0012"
                     /evalue="5.00E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE257_RS37390"
                     /protein_end="1204"
                     /protein_start="1190"
                     /score="16.5"
                     /tool="antismash"
                     /translation="LAVMKAGGAYLPVD"
     CDS_motif       complement(7348..7437)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0011"
                     /evalue="3.20E-05"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IE257_RS37390"
                     /protein_end="995"
                     /protein_start="965"
                     /score="16.2"
                     /tool="antismash"
                     /translation="TQLARLLEHEHASLATAQQASGLQGEAPLF"
     aSDomain        complement(7480..8352)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_Condensation_Dual.
                     1"
                     /domain_subtypes="Condensation_Dual"
                     /evalue="2.30E-106"
                     /label="IE257_RS37390_Condensation_Dual.1"
                     /locus_tag="IE257_RS37390"
                     /protein_end="951"
                     /protein_start="660"
                     /score="347.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLVQDH"
                     /tool="antismash"
                     /translation="DVYPLGPLQEGLLFHHLMAEGGDDAYVMPAVMEFASRTGLDTFLA
                     AFQNVLDRHDIFRTSFVWEGLPDPVQVVWRRAAMPVTDVTLPADAEDPVTDLIAAVGLS
                     MDLGRAPLITVHRAAVPGADRWMALVRVHHLVQDHMALELLLSEVRAFLTGRGADLPEP
                     MPFRNFVAQARQEAEGSGQREYFAELLGDFDEPSAPYGVTDVHGDGTAVSRGVVPFAPE
                     SERRLREVARRLRVSAATVLHVAWARTVGAMSGRDDVVFGTVLFGRMSGGAEAGQVPGP
                     FINTLPVRVR"
     CDS_motif       complement(7486..7581)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0010"
                     /evalue="4.50E-12"
                     /label="C5_dual_260-291"
                     /locus_tag="IE257_RS37390"
                     /protein_end="949"
                     /protein_start="917"
                     /score="38.4"
                     /tool="antismash"
                     /translation="DVVFGTVLFGRMSGGAEAGQVPGPFINTLPVR"
     CDS_motif       complement(7828..7860)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0009"
                     /evalue="2.50E-04"
                     /label="C4_dual_169-182"
                     /locus_tag="IE257_RS37390"
                     /protein_end="835"
                     /protein_start="824"
                     /score="13.9"
                     /tool="antismash"
                     /translation="PFRNFVAQARQ"
     CDS_motif       complement(7894..7956)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0008"
                     /evalue="6.70E-06"
                     /label="C3_dual_135-156"
                     /locus_tag="IE257_RS37390"
                     /protein_end="813"
                     /protein_start="792"
                     /score="19.0"
                     /tool="antismash"
                     /translation="HHLVQDHMALELLLSEVRAFL"
     CDS_motif       complement(8164..8277)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0007"
                     /evalue="8.50E-14"
                     /label="C2_dual_024-063"
                     /locus_tag="IE257_RS37390"
                     /protein_end="723"
                     /protein_start="685"
                     /score="44.1"
                     /tool="antismash"
                     /translation="YVMPAVMEFASRTGLDTFLAAFQNVLDRHDIFRTSFVW"
     CDS_motif       complement(8305..8346)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0006"
                     /evalue="2.20E-05"
                     /label="C1_dual_004-017"
                     /locus_tag="IE257_RS37390"
                     /protein_end="676"
                     /protein_start="662"
                     /score="17.0"
                     /tool="antismash"
                     /translation="YPLGPLQEGLLFHH"
     aSDomain        complement(8497..8694)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_PCP.1"
                     /evalue="7.80E-25"
                     /label="IE257_RS37390_PCP.1"
                     /locus_tag="IE257_RS37390"
                     /protein_end="612"
                     /protein_start="546"
                     /score="78.9"
                     /tool="antismash"
                     /translation="EEVLCAAFAEVLELDRVGAEDDFFALGGHSLLAIRLVERLRAQGV
                     TVPVRALFETPTPAGLALTAG"
     aSModule        complement(8497..10329)
                     /domains="nrpspksdomains_IE257_RS37390_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE257_RS37390_PCP.1"
                     /incomplete
                     /locus_tags="IE257_RS37390"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(9274..9393)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0005"
                     /evalue="2.90E-23"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE257_RS37390"
                     /protein_end="353"
                     /protein_start="313"
                     /score="74.3"
                     /tool="antismash"
                     /translation="RATTLGAFGHQDLPFDRLVEDLAPARSLSRHPLFQVMLTL"
     aSDomain        complement(9433..10329)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37390_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="6.40E-114"
                     /label="IE257_RS37390_Condensation_LCL.1"
                     /locus_tag="IE257_RS37390"
                     /protein_end="300"
                     /protein_start="1"
                     /score="371.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIASDG"
                     /tool="antismash"
                     /translation="IALSFAQRRLWFISQLEGPSATYNVPMVLPLGAQIDRAALNTALR
                     DVIGRHEVLRTVFVTVDGEPYQDVRKIDDLAWELSVTEVAPAELSAAIAAAEGYAFDLA
                     AEVPVRAELLVASPDEQVLVVVLHHIASDGWSMGPLTRDLMTAYQARSEGREPQWEPLP
                     VQYADYALWQRDLMGDADDPTSLMHRQLGYWRDALAGLPDGIALPFDRPRPAAASYRGH
                     RVRLELAAPTHARLLQLAQDEGVTVFMTLQAVLAVLLSRLGAGTDIAVGTDVAGRSDEA
                     LDDLVGFFVNTLVLRTDL"
     CDS_motif       complement(9442..9531)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0004"
                     /evalue="2.10E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE257_RS37390"
                     /protein_end="297"
                     /protein_start="267"
                     /score="42.6"
                     /tool="antismash"
                     /translation="DIAVGTDVAGRSDEALDDLVGFFVNTLVLR"
     CDS_motif       complement(9802..9837)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0003"
                     /evalue="2.10E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE257_RS37390"
                     /protein_end="177"
                     /protein_start="165"
                     /score="17.0"
                     /tool="antismash"
                     /translation="QYADYALWQRDL"
     CDS_motif       complement(9886..9951)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0002"
                     /evalue="2.20E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE257_RS37390"
                     /protein_end="149"
                     /protein_start="127"
                     /score="36.1"
                     /tool="antismash"
                     /translation="LHHIASDGWSMGPLTRDLMTAY"
     CDS_motif       complement(10153..10269)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37390_0001"
                     /evalue="6.70E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE257_RS37390"
                     /protein_end="60"
                     /protein_start="21"
                     /score="41.0"
                     /tool="antismash"
                     /translation="ATYNVPMVLPLGAQIDRAALNTALRDVIGRHEVLRTVFV"
     gene            complement(10332..>13949)
                     /locus_tag="IE257_RS37395"
     CDS             complement(10332..>13949)
                     /NRPS_PKS="Domain: PCP (49-117). E-value: 6.2e-27. Score:
                     85.6. Matches aSDomain: nrpspksdomains_IE257_RS37395_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (131-431). E-value:
                     2.6e-106. Score: 346.9. Matches aSDomain:
                     nrpspksdomains_IE257_RS37395_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (600-1003). E-value:
                     1.5e-115. Score: 378.1. Matches aSDomain:
                     nrpspksdomains_IE257_RS37395_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1114-1183). E-value: 2.5e-26.
                     Score: 83.7. Matches aSDomain:
                     nrpspksdomains_IE257_RS37395_PCP.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE257_RS37395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_189974537.1"
                     /sec_met_domain="PP-binding (E-value: 2.4e-17, bitscore:
                     51.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.1e-65, bitscore:
                     209.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 9.5e-125, bitscore:
                     404.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="EGRLPEYMVPSAVVVLEALPLTGNGKLDRKALPAPELTGSADRGP
                     ASPQEALLCAAFEQVLGVEGVGVGDDFFELGGHSLLAVRLVSRIRAVMGVEVPLQAVFE
                     APTVAAMAARLAGAGEARLALEARERPERIPLSFAQQRLWFIDQLEGSTAYHIPILLPL
                     PGDVDREALGEALRDVIGRHEVLRTVFATVDGEPYQRIIDLDDLAWEIDVVEVAPEALD
                     GAIAEAKGRAFDLAAEAPIRAWLFESGPQESTLLIVVHHIAGDGWSDGPLSRDVATAYT
                     ARREGRAPEWVPLPVQYADYALWQRELLGDEQDPESPMARQIAQWRDALAGIPEELELP
                     VDRPRPAVASHRGIDAPVVIPAEVHARLVKVARAEGVTMNMVLQSALAVLLSKLGAGQD
                     IPMGSANAGRTDVALDDLVGFFVNTLVVRADLSGDPEFRNVLGRVREATLSGMANQDVP
                     FERLVEDLAPARSRARHPLFQVMLNVQNGGSATPDLPAAPVGVTAGATAAKFDLTFGLG
                     EVFDEHGAPAGLRGAVTAAADLFDAGSAERIALRFGRVLSAVAADPRVPVSGVDVLDEA
                     ERHQLLVEWQVDPVDAAPATLLELFEAQAARTPDAVAVVAEGAEVTYGQLDARANRLAR
                     LMLDRGVGPESVVGLLHERSADLVVAMVAVVKTGGAYLPLDPAYPDDRVTYTLEDAGAT
                     LVLASPQLTARANGFGVPVVVADGSAAAAADRGPLGPDERTAASPAHPAYVIYTSGSTG
                     RPKGVVVSHEAVTGMLAQTRSLLGFGPGDVWSWFHSFAFDFSVWELWGALLHGGRAVVV
                     PVGVSRSPEAFLDLLERERVTVLSQTPSAFYQLMATEERSPQALASLRAVVFGGEALDP
                     ARLAGWWERHPQGPRLVNMYGITETTVHVTYQELAAEPAAPGSVIGRGLPGLRVYVLDE
                     WLRPVPPGVPGEVYVAGGQLARGYLGRPALTAERFVADPFGTGRLYRTGDRARWSADGC
                     LVFAGRADEQVKVRGFRIEPDEVAAAVAGHPAVAQAVVIAREDVPGDTRLVAYVTAANT
                     EPDLDGPGLRSLVREFAAERLPSFMVPAAVVVVESLPLTVNGKLDRKALPAPEYGTTGG
                     REPSDEREKAVCDAFAAVLGLESVGVDDDFFALGGHSLLAVRLINRIRTVLNAEVEIAA
                     LFDAPTPAGLAERLGQQTEQAQQAPTRPALRPRRNQEES"
     aSDomain        complement(10398..10604)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37395_PCP.2"
                     /evalue="2.50E-26"
                     /label="IE257_RS37395_PCP.2"
                     /locus_tag="IE257_RS37395"
                     /protein_end="1183"
                     /protein_start="1114"
                     /score="83.7"
                     /tool="antismash"
                     /translation="EKAVCDAFAAVLGLESVGVDDDFFALGGHSLLAVRLINRIRTVLN
                     AEVEIAALFDAPTPAGLAERLGQQ"
     aSModule        complement(10398..13553)
                     /complete
                     /domains="nrpspksdomains_IE257_RS37395_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE257_RS37395_AMP-binding.1"
                     /domains="nrpspksdomains_IE257_RS37395_PCP.2"
                     /locus_tags="IE257_RS37395"
                     /monomer_pairings="Thr -> Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(10557..10595)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0014"
                     /evalue="4.30E+01"
                     /label="C3_starter_134-155"
                     /locus_tag="IE257_RS37395"
                     /protein_end="1130"
                     /protein_start="1117"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="VCDAFAAVLGLES"
     CDS_motif       complement(10653..10679)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0013"
                     /evalue="8.20E-02"
                     /label="NRPS-A_a10"
                     /locus_tag="IE257_RS37395"
                     /protein_end="1098"
                     /protein_start="1089"
                     /score="5.9"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     CDS_motif       complement(10749..10793)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0012"
                     /evalue="5.80E+00"
                     /label="C3_DCL_135-156"
                     /locus_tag="IE257_RS37395"
                     /protein_end="1066"
                     /protein_start="1051"
                     /score="-0.1"
                     /tool="antismash"
                     /translation="LDGPGLRSLVREFAA"
     CDS_motif       complement(10911..10973)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0011"
                     /evalue="5.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IE257_RS37395"
                     /protein_end="1012"
                     /protein_start="991"
                     /score="31.4"
                     /tool="antismash"
                     /translation="FAGRADEQVKVRGFRIEPDEV"
     aSDomain        complement(10938..12146)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37395_AMP-binding.1"
                     /evalue="1.50E-115"
                     /label="IE257_RS37395_AMP-binding.1"
                     /locus_tag="IE257_RS37395"
                     /protein_end="1003"
                     /protein_start="600"
                     /score="378.1"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEAQAARTPDAVAVVAEGAEVTYGQLDARANRLARLMLDRGVGPE
                     SVVGLLHERSADLVVAMVAVVKTGGAYLPLDPAYPDDRVTYTLEDAGATLVLASPQLTA
                     RANGFGVPVVVADGSAAAAADRGPLGPDERTAASPAHPAYVIYTSGSTGRPKGVVVSHE
                     AVTGMLAQTRSLLGFGPGDVWSWFHSFAFDFSVWELWGALLHGGRAVVVPVGVSRSPEA
                     FLDLLERERVTVLSQTPSAFYQLMATEERSPQALASLRAVVFGGEALDPARLAGWWERH
                     PQGPRLVNMYGITETTVHVTYQELAAEPAAPGSVIGRGLPGLRVYVLDEWLRPVPPGVP
                     GEVYVAGGQLARGYLGRPALTAERFVADPFGTGRLYRTGDRARWSADGCLVFAGRADEQ
                     VKVR"
     CDS_motif       complement(11052..11141)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0010"
                     /evalue="2.60E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IE257_RS37395"
                     /protein_end="965"
                     /protein_start="935"
                     /score="51.6"
                     /tool="antismash"
                     /translation="PPGVPGEVYVAGGQLARGYLGRPALTAERF"
     CDS_motif       complement(11661..11720)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0009"
                     /evalue="3.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="IE257_RS37395"
                     /protein_end="762"
                     /protein_start="742"
                     /score="34.8"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVVSH"
     CDS_motif       complement(11919..11957)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0008"
                     /evalue="5.00E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="IE257_RS37395"
                     /protein_end="676"
                     /protein_start="663"
                     /score="13.5"
                     /tool="antismash"
                     /translation="AVVKTGGAYLPLD"
     CDS_motif       complement(12498..12614)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0007"
                     /evalue="4.20E-20"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE257_RS37395"
                     /protein_end="483"
                     /protein_start="444"
                     /score="64.1"
                     /tool="antismash"
                     /translation="REATLSGMANQDVPFERLVEDLAPARSRARHPLFQVMLN"
     aSDomain        complement(12654..13553)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37395_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.60E-106"
                     /label="IE257_RS37395_Condensation_LCL.1"
                     /locus_tag="IE257_RS37395"
                     /protein_end="431"
                     /protein_start="131"
                     /score="346.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAGDG"
                     /tool="antismash"
                     /translation="ERIPLSFAQQRLWFIDQLEGSTAYHIPILLPLPGDVDREALGEAL
                     RDVIGRHEVLRTVFATVDGEPYQRIIDLDDLAWEIDVVEVAPEALDGAIAEAKGRAFDL
                     AAEAPIRAWLFESGPQESTLLIVVHHIAGDGWSDGPLSRDVATAYTARREGRAPEWVPL
                     PVQYADYALWQRELLGDEQDPESPMARQIAQWRDALAGIPEELELPVDRPRPAVASHRG
                     IDAPVVIPAEVHARLVKVARAEGVTMNMVLQSALAVLLSKLGAGQDIPMGSANAGRTDV
                     ALDDLVGFFVNTLVVRADL"
     CDS_motif       complement(12663..12752)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0006"
                     /evalue="1.20E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE257_RS37395"
                     /protein_end="428"
                     /protein_start="398"
                     /score="33.8"
                     /tool="antismash"
                     /translation="DIPMGSANAGRTDVALDDLVGFFVNTLVVR"
     CDS_motif       complement(13020..13058)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0005"
                     /evalue="2.20E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE257_RS37395"
                     /protein_end="309"
                     /protein_start="296"
                     /score="20.1"
                     /tool="antismash"
                     /translation="QYADYALWQRELL"
     CDS_motif       complement(13107..13172)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0004"
                     /evalue="5.90E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE257_RS37395"
                     /protein_end="280"
                     /protein_start="258"
                     /score="28.4"
                     /tool="antismash"
                     /translation="VHHIAGDGWSDGPLSRDVATAY"
     CDS_motif       complement(13374..13490)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0003"
                     /evalue="3.00E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE257_RS37395"
                     /protein_end="191"
                     /protein_start="152"
                     /score="45.3"
                     /tool="antismash"
                     /translation="TAYHIPILLPLPGDVDREALGEALRDVIGRHEVLRTVFA"
     CDS_motif       complement(13509..13538)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0002"
                     /evalue="3.10E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE257_RS37395"
                     /protein_end="146"
                     /protein_start="136"
                     /score="10.1"
                     /tool="antismash"
                     /translation="SFAQQRLWFI"
     aSDomain        complement(13596..13799)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37395_PCP.1"
                     /evalue="6.20E-27"
                     /label="IE257_RS37395_PCP.1"
                     /locus_tag="IE257_RS37395"
                     /protein_end="117"
                     /protein_start="49"
                     /score="85.6"
                     /tool="antismash"
                     /translation="EALLCAAFEQVLGVEGVGVGDDFFELGGHSLLAVRLVSRIRAVMG
                     VEVPLQAVFEAPTVAAMAARLAG"
     CDS_motif       complement(13848..13874)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37395_0001"
                     /evalue="8.20E-02"
                     /label="NRPS-A_a10"
                     /locus_tag="IE257_RS37395"
                     /protein_end="33"
                     /protein_start="24"
                     /score="5.9"
                     /tool="antismash"
                     /translation="GKLDRKALP"
ORIGIN
        1 gcggaaccac cacacccttc ggccgacccg tcgaacccga cgtgaaaatc acatacgccg
       61 gatgcgacgg cagcacccgc acacccagcg gcccgtcagc gacacccgcc aactcatcca
      121 cgacggcggg ctcgtcgacc acgacaaccg gaacaccgga cggcaccaca ccggccaccg
      181 cctgcgaggt caccaccacg accggcgcag catcctccag cacgaacgcg acccgctcgg
      241 acggatactc cggatcgatc ggcagatacg caccacccgc cttcaccacc gccagcagag
      301 cgaccaccat gtcgacacca cgctccaacg cgacaccgac caccgactcc gcacccacac
      361 cacgcgacac caacagacgc gccagacgat tcgcccgccc atccaactcc gcgtacgagt
      421 gctccacacc ctcgaacacc accgcaaccg cacccggagt acgccccacc tgcgcctcga
      481 acaaccccgg cagagaagag gaaccgacct ccacggccgt gtcgttccag tccaccagga
      541 cctgccgacg ctcagccgcg tccagcagat cgactccgct cagtcgtgtc tccggctcgg
      601 ccaccaggag ttccagcgcc cgccggacct gcgtcgcgag ccgcgcgacg gtgtcgcggc
      661 cgaagaggtc cacggaggcg gtcaccgaac cctgcaggcc cgccggagcg ccgccctggt
      721 cgaacagttc gacgaagtcg agttccaggt cgaacttcgc cgcccgtacg tcgaccaccg
      781 cgtccgccgc ggagccttcg gactcggcgc ccgaccgctc cagaacgatc cgctcgttgt
      841 tgtggacggt cagcatcacc tggaccagcg ggtgccgcgc cagggagcgg gtcggggcca
      901 gctcctcgac cagcttctcg aacggcacgt cctgctgcgc gagtgcggcc cacccggtct
      961 gccgcacccg ggcgagcagc tccttgaagg tggggtcgcc ggacaggtcg gcgcgcagca
     1021 cgagcgtgtt gacgaagaag ccgatgacgt cgtccagcgc gacgtcggtg cggccggcga
     1081 ccgctgtgcc gatggggatg tccgtacccg cgcccaggcg ggacagtacg accgcgagtg
     1141 cggcctggag gaccatgaag accgtggcgt cttcggcccg cgccacctcg gccagccggg
     1201 cgtggaccgc tgcggggatc tccagcggca cgccgtggcc gcggtgcgaa gcgatcgcgg
     1261 gacgggtgtg gtcgaagggc agggagagtt cttccggcgc tccggtcagg ttcgcgcgcc
     1321 agtaggcgat ctggcgggcc atcaggctgt cggggtcctg ctcgtcgccc agcagctcgc
     1381 gctgccacag ggtgtagtcg gcgtactgga ccggcagcgg ctcccactcg ggggctcggc
     1441 cttcggcacg cgcggtgtag gccgaggtca cgtctcgcag cagcggtccc atcgaccaac
     1501 cgtcggtcgc gatgtggtgg accacgagga cgaggacctg ctcctccggt ccggttcgga
     1561 gcagcgaagc gcggatgggc acctcggtgg ccaggtcgaa cgtgtgcgcc tccagctccg
     1621 cgaccgtgac gtcgagttcg gcggggttca catcggtgac cgtgaggctc cagtccaggt
     1681 cctccagttt caggatgtcc tggaggggct caccggcaac cgtcgggtag accgtgcgca
     1741 gtacctcgtg gcgtccgagg acgtcccgaa gggccgtgtt gagcgcatcg ccgtcgatcc
     1801 ggcccgccag ccgcctggcg atcgggatgt tgtaagtggc gctcgggcct tcgagctgcg
     1861 agaggaacca caaccgacgc tgcgcgaaag acaacggaaa catcaggact cctcctggtt
     1921 gcgcatcgac cgcaacgacg gcctagctga cttttcattt ccaagctgct gtgccagtcc
     1981 ggcaaccgtc ggcgcctgca gaagcgcctg cagcggcgcc tcgatgccca gcgccgcacg
     2041 gatccggctg gtgagtcgaa cggcgagcaa ggagtgcccg cccaattcga agaagtcgtc
     2101 gtcgacgccc acgctctcga ggccgaggac ttcggcgaag agcgtgcaca ggatctcctc
     2161 ccgtgcgtcg gccggtcctc tgccggctcc ggctgtgtac tcgggggcgg gaagggcctt
     2221 gcggtccagc ttcccgttca cggacagcgg cagcgcgtcc aggacgacga ccgccgacgg
     2281 aaccatgtgt gccggcaggt gatccgacgc cacatccacg actgtgaagg caagttcgtc
     2341 cgcctcgatc ccacccggaa tcgggacgac gtaggcgacc aggcgcttgt cgcccggcac
     2401 gtcctcgcgg gcgatcacag cggcctgcgc cacctgcgga tgggccgcga tcacggcctg
     2461 gacctcgccc ggctcgatcc ggaaaccacg gaccttgacc tgctcgtccg cacgccccag
     2521 gtactccacc tgaccgtcgg ccgtccagcg tgcgatgtcg cccgtacggt aaagacgctc
     2581 accggtgccg tacggagaag ccacgaaccg ctccgccgtc agacccggcc ggttcgcata
     2641 accacgagcc agctgcacac ccgcgagata caactcaccc gccacaccga cgggaaccgg
     2701 agccagccgc gcgtccagca cgtacacccg cgtgttcgcc accggagctc cgatcggcac
     2761 cacggcaccg tccgcgcccg gctcgcactc ccacgcggtc acgtcgaccg aggcctccgt
     2821 cggcccgtac aggttgtgca gctccacacc cgccagaacc ccgaagaagc gatcccgtac
     2881 cgaagccgac aacgcctcac ccgagcacac cacataccgc agcaccccgg cggtgtccat
     2941 cgcggactca tccgccagga acgcctcgag catcgacggc acgaagtgcg ccaccgtcac
     3001 ccgctgccca cacaccacac ccgccagata cgccggatcc ttatgacccc ccggacgtgc
     3061 caccaccaga gcagcaccca ccgacagcgg ccagaagaac tcccacaccg acacgtcgaa
     3121 accgaacggc gtcttctgca acacccggtc cgcaccaccg atcccgaacc gcgcctgcat
     3181 ccacgcaaga cggttcacga tcccctcgtg cgaaaccacc acacccttcg gccgacccgt
     3241 cgaacccgac gtgaaaatca cgtacgccgc accctccgac gccacctcca cgcccaactg
     3301 ctcacccgac agacccgcca actcacgcac cacggcgggc tcgtcgagga tcaccagcgg
     3361 cacatcgaca gccagtccgc ccgccaccgc ggacgacgag accaccacgc ccgcgcctgc
     3421 ggtctccacc atgtaggcgg tccggtccgc aggaagcccc ggttcgatcg gcaggtacgc
     3481 accgcccgcc ttcaccaccg ccagcagagc gaccaccatg tcgacaccac gttccaacgc
     3541 gacaccgacc accgactccg cacccacacc acgcgccacc aacagacgcg ccagacgatt
     3601 cgcccgccca tcaagctccg cgtacgaaac ctccacaccc tcgaacacca ccgcaaccgc
     3661 acccggagta cgccccacct gcgcctcgaa caaccccgac agagaagagg aaccgacctc
     3721 caccgccgtg tcgttccagt cgcgcacgac ccggtccagc cctgcttcgt ccagcaccgg
     3781 cacggagcgc agcggcgtct gcgcaccgcc gtcgagcgcc cgctccagcg cggacaccag
     3841 accgtcgacg gccgtgcaca gcagtgcctg cacctccgcc gggtccgcgg gcgccaccgc
     3901 ttccacggcc atccggatcg acctaccgct gtcgttcacg gcgaccgcga gcggatagtt
     3961 ggtcgtctcc ttggagagca gggtctggat cgcgggcggc tccgcctcgc cgtgcccgtt
     4021 gtcggccggt gccgccgtca tcgacggtcc gtccgacggg tcctgtgtat ggcggtagtt
     4081 gaggaaggac gtgaacaacg gcgagcccgc cgtgatgcca ctggactgct gggccagagc
     4141 gagcgaggcg tgctcgtgct caaggagccg ggccagctgg gagcgcatcg tggacaccgc
     4201 gtccacgacg tccggcccgt ccgtccgcac gcgcagcggg agcgtgttga tgaaggggcc
     4261 cggtacgcgg tcgccgcccg ctccggcgtt catccggccg aacagcaccg tcccgaacac
     4321 cacgtcgtcc cggccgctga tcgcgccgag cacgcgtgcc cacgccacgt gcatgaccgt
     4381 ggccacgctg gcacccagtc ggcgcgagac cacccgcagc cgctcgttca gcgccgggtc
     4441 cagctcgccg gtggcgcgtt cggtgccggt gccggccccg cgcacgtcgg tcagtccgta
     4501 cggggccgtc ggctccgtga cgtcaccgag cagcgccgcg aagtaccgct cgtgctcctc
     4561 ccgggggacc ccgccgcggg cctgagccac gaagtcgcgg aacggcagcg gctgcggcag
     4621 ttcgtcgccg tggccggtga ggaacgccgc gatctccccc agcaggacct ccagcgcggt
     4681 gtggtcctgc accatgtggt ggatcctgac cagtccgagc cagcggcctt ccgggccctc
     4741 ggtcgtgtgc agctcgacca ggggtgcccg ggacaggtcc atcgacaggc cgacggcttc
     4801 cgccagttct gtcgcgaggt cggtgccgcg ggggtcgagg gtcacttctc ggaccgggag
     4861 ttcggccttg cgccagacga cctggacggg ctcccgaagc ccgtcccaga cgatgccggt
     4921 ccgcaggatg tcatgccggt ccaggaccag ttggagggcc tcggcgaacc ggtcgagcag
     4981 ctcgcgggag ccgaattcga ggacgttggg ctggacgtag acgtcgtcgc cgccgtcggc
     5041 gagcaggtgg tggaagagca ggccctcctg gaggggggcg agggggtaga tgtcggcgat
     5101 gttggccgcg cctcccgcca cggtcgccgc gacgcggtcg atctcctcgc cgctcagctc
     5161 gacaagggtg agcatctccg gggtgatcgc ggttgcgtcg gccgggatca ggttgtccgg
     5221 cacgtgggcc ggccgtaggc cttccgagag tgcgaggccg gccggtgtgg ggctgtcgaa
     5281 cagcgcccgt accgacagcg ccacgccctg ggcctgtacc cggccgatga gccggacggc
     5341 gagcagcgag tggccgccga gggcgaagaa gtcgtcgtcg acgccgacgc tctccaggcc
     5401 gaggacttcg gcgaacgcgg cgcagaggat ctcctcgcgg gagttcgacg ggccgcggcc
     5461 gccaccgctg ccggcggtga cgtcgggggc gggcagggcc ttgcggtcga ccttgccgtt
     5521 cgcggtcagc ggcagctcgt cgagaacgac gaacgccgag ggcaccatgt aggccggaag
     5581 gtcctggagc aggtgtaccc gcagggccgc cacgtccggg gcgagaccgc cgtcggcgac
     5641 cacgtaggcc gccagcagcg cgtcgccgga ggtgtcgcgg cgtacggccg cgaccgcgcg
     5701 cgccacaccc tcgtggcgct ccagaacagc ttccacctcg cccagttcga tacggaagcc
     5761 gcgcaccttc acctggtcgt ccgcacggcc caggcactcc agctcaccgt ccgcacgcca
     5821 acgagccagg tccccggtcc gatacagccg ctccccgaac ccgtacggcg acgcgacgaa
     5881 ccgctccgcc gtcagacccg aacgacccac ataaccacgg gccaactgag cccccgccaa
     5941 atacagttcg cccgccacac cgaccggagc cggacgcatc gaacgatcca gcacatacgc
     6001 ccgcacattc gcgaacggcc gacccaccga caccacatcc gaagcgacct ccgccgacgt
     6061 ggcccacacc gtcgcctcgg tcggcccgta caggttcacc gcccgcacac ccaggtccgt
     6121 gaaccgctgc gccaactcac gcggcagcgc ctcaccaccc accagcgccc gcaccccgac
     6181 cggccagccc tcctcctcca acaacgcccg ccacaacgac ggcaccgcct gcaacacatt
     6241 cgcaccagac gaacacacca gctccgccag cgccgcgggg tcccgcaccg tctcacgcga
     6301 ggcgagcacc accgacgcac ccgacaccaa cggcaggaac aactccaacg ccgcgatgtc
     6361 gaacgacacc gtggtcaccg ccaccagccg atccccggcc gcgacaccca cccgctcacc
     6421 agcagcgaac aaatggttca ccaacgcacc gtgcggaatc accacaccct tgggacgacc
     6481 cgtcgaaccc gacgtataaa tcacatacgc cgcattgcac gactccagct ccacaccccc
     6541 acgcaccggc acgtccggca cgtccgacag aaccgccaac tccgccacca ccgacggatc
     6601 atcgaccaca accaccggca cacccgccgg cacgacgtcc gcaaccgccg tgtgcgacag
     6661 aaccagcggg acacccgcat cggcgagaac ataagcaatc cgctccgccg gatactccgg
     6721 gtccaccggc agatacgccc cgcccgcctt catcaccgcc aacagcgcaa ccaccagatc
     6781 gaccccacgg tccatcacca cacccacgac cgactccggc ccgacaccac gcccacgcag
     6841 caaccgcgcc aaccggctca cccgcgcatc cagctcggcg tagccgagtt cgacgtcccc
     6901 ctgcaccagc gcgatcgcgt ccggtgtccg ggccgcctgc gcctcgaaca gccccggcag
     6961 agtggctgcg ccggtctcgg cctccgtgtc gttccactcc tccaccaccc ggtggagccc
     7021 ggcctcgtcc agcactcgca ccgcgccgag cggtgcctcg gggccgccgt cgagcgccgt
     7081 ttccagtgcc tggacgagct cctccgtggc cgtccgcacc aggaggccga ccgcctccgg
     7141 gtcgatcggg ccgactgcgt cgaccgtcag cgcgaggccg acgccctcgc cgtcgtcgtc
     7201 caccgcgaca ccgagcgggt agttggtacg ttcgcgggcg tacagcaggc gagcatccag
     7261 gtcgtccggg tgctcgtcgg ccgcgggctc ccgctccgcc tgctcctcgc cccgtcccgc
     7321 gttgtggcgg tagttgagga aggcggtgaa gaggggcgcc tcgccctgga ggccactggc
     7381 ctgctgggcg gtcgccagcg aggcgtgttc gtgctccagc agccgcgcca gctgggtgcg
     7441 catgtccgac accgccgtca ggaccccggt gtcgctcgta cggacgcgca ccgggagcgt
     7501 gttgatgaag ggcccgggca cctgccccgc ttcggcgccg ccgctcatcc ggccgaacag
     7561 caccgtcccg aagacgacat cgtcccgccc ggacatcgca ccgacggtgc gcgcccaggc
     7621 gacgtgcaga acggtcgcgg cgctcacgcg cagccgccgc gccacctcgc gcagccggcg
     7681 ctcggactcc ggggcgaagg gcaccacccc gcggctgacc gccgtgccgt cgccgtgcac
     7741 gtccgtgacc ccgtacgggg ccgacggctc gtcgaagtcg ccgagcagtt cggcgaagta
     7801 ctcccgctgc ccgctgcctt cggcctcctg gcgcgcctgc gccacgaagt tccggaacgg
     7861 catcggctcg gggaggtccg cgccgcgtcc ggtgaggaac gcccggacct ccgagagcag
     7921 cagctccaga gccatgtggt cctgcaccag gtggtgcact cggaccagtg ccatccatcg
     7981 gtcggcaccg gggactgcgg cgcggtgcac cgtgatcagt ggcgcgcgtc cgaggtccat
     8041 cgacaggccc accgccgcga tgaggtcggt gaccgggtcc tcggcgtccg cggggagggt
     8101 gacgtcggtg acgggcatcg ctgcccggcg ccacaccacc tggaccggat ccggcagtcc
     8161 ttcccagacg aaggaggtcc ggaagatgtc gtgccggtcc agcacgttct ggaacgccgc
     8221 caggaaggtg tcgaggccgg tgcgcgaagc gaactccatg accgcgggca tcacgtatgc
     8281 gtcgtcgccg ccctccgcca tcaggtggtg gaagagcagg ccctcctgga ggggcccgag
     8341 cggatagacg tcagcgatgt tcggggctcc gccgtccacg gtcgcgacga cccgtgcgag
     8401 ctcctcggcc gtgagcgtca ccagcggcag catctccggg gtgatctcgg tcgcgcccgc
     8461 cgggatcagg ttctccggcg cgtccggccg ccgggctccg gccgtgagcg cgagcccggc
     8521 cggggtcggc gtctcgaaga gcgcccgtac cggcacggtc accccctgcg cgcggagccg
     8581 ctcgaccagc ctgatcgcca gcagggagtg cccgccgagg gcgaagaagt cgtcctcggc
     8641 gccgacccgg tccagctcga gcacctcggc gaacgcggcg cacagcacct cttcgcgggc
     8701 gttcgcgggt ccgcgcccgg cggcgacggg gtacgtcggc ggggcgggca gcttgcccgt
     8761 gtccaccttc ccgttcgccg tcaggggcag ttcgtcgagg agtaccacag ccgcgggaac
     8821 catcgagtcc ggcagctgtt cccgtacgaa cgcgcgcagc tccgacgggt cgatctccat
     8881 gcccggcgcg ggcacgacgt acgcgaccag cctgcggtcg accgcctcgg cggcggggcc
     8941 ggccgcggcc gctccggtgc tcacgcggcc cgggaagacc gcttcggcac ccgagccgtc
     9001 cacgatccgt acgccgctca gcggcagctc cggcgcgccc gtcagggtgt ccagcgcgcg
     9061 cgtcaggcag tcggcgaaca ggagggccgt tccctcgtcg aacaggtccg cggcggccgt
     9121 caccgatcct tggatcccgg aggggagacc gtccggcccg tagacctcgg tgaaggacag
     9181 ttcaaggtcg aacttggcct gcgtcgcccc gtcgggggtg accgccgaca ccgcgacgga
     9241 ctcttcgtcc cgtacggtcc gcgcggcgtt ctgcagggtc agcatcacct ggaagagcgg
     9301 atgccgggac agcgaccgcg ccggggccag gtcctcgacg agccggtcga acggcaggtc
     9361 ctggtgtccg aaggccccca gggtcgtcgc ccgtacccgg cccagcgtct cgcggaacgt
     9421 cgggtcgccg gacaggtccg tccgcagcac cagggtgttg acgaagaagc cgaccaggtc
     9481 gtccagcgcc tcgtccgacc gacccgcgac gtcggtgccg accgcgatgt ccgtgcccgc
     9541 gccgaggcgg ctcagcagga cggcgagaac cgcctgcagc gtcatgaaca ccgtgacgcc
     9601 ctcatcctgc gccagctgca gcagccgggc gtgggtcggc gcggcgagtt ccagccgtac
     9661 ccggtggccc cggtacgagg ccgcggccgg ccgcggccgg tcgaacggca gcgcgatccc
     9721 gtccgggagt ccggccagcg catcgcgcca gtagccgagc tgccggtgca tgaggctcgt
     9781 cgggtcgtcc gcgtcgccca tcagatcgcg ctgccagagc gcgtagtccg cgtactggac
     9841 cggcagcggc tcccactgcg gctcccggcc ctcgctgcgg gcctgatacg ccgtcatgag
     9901 gtcccgcgtg agcggcccca tcgaccagcc gtcgctggcg atgtggtgga gcaccacgac
     9961 cagcacctgc tcgtccggcg aggcgaccag cagctcggcg cggacgggca cttcggccgc
    10021 caggtcgaag gcgtacccct cggcggccgc gatcgcggcc gacagctccg ccggggccac
    10081 ctcggtgacg gacagttccc acgccaggtc gtcgatcttc cggacgtcct ggtacggctc
    10141 gccgtccacg gtgacgaaca cggtccgcag gacctcgtgg cggccgatga cgtcccgcag
    10201 cgcggtgttc agggccgctc ggtcgatctg cgcgcccagc gggagcacca tcggaacgtt
    10261 gtaggtggcg ctcggccctt ccagctgcga tatgaaccac agccgccgct gcgcgaatga
    10321 caaagcgatc atcaggactc ctcctggttg cgccgcggcc gaagggccgg cctggtcggt
    10381 gcctgctgcg cctgttccgt ctgctgcccc agccgctcgg cgagtcccgc cggggtcggg
    10441 gcgtcgaaca gggccgcgat ctccacctct gcgttcagta ccgtgcggat ccggttgatc
    10501 aggcggacgg cgagcagtga atggccgccg agggcgaaga agtcgtcgtc gacgcccacg
    10561 ctctccagtc cgaggaccgc ggcgaacgcg tcgcagacgg ccttctcgcg ctcgtcggac
    10621 ggctcgcgtc cgccggtcgt gccgtactcg ggcgcgggca gggccttgcg gtcgagcttc
    10681 ccgttgacgg tcagcggcag cgactccacc acgacgacgg ccgcggggac catgaacgac
    10741 ggcagtcgct cggccgcgaa ctcccgtacc agggaccgca ggcccggacc gtcgaggtcc
    10801 ggctccgtgt tcgccgccgt gacgtaggcg acgaggcggg tgtcccccgg cacgtcctca
    10861 cgagcgatga cgacggcctg tgcgacggcc ggatgtccgg ccaccgccgc cgccacctcg
    10921 tccggctcga tgcggaagcc gcgcaccttc acctgctcgt ccgcgcggcc cgcgaacacc
    10981 aggcagccgt ccgcactcca ccgtgcccgg tcgcccgtgc ggtacagccg tccggtgccg
    11041 aaggggtccg ccacgaaccg ctccgccgtc agcgccggcc ggccgaggta cccgcgggcc
    11101 agctgaccgc ccgcgacgta cacctcgccc gggacccccg gagggaccgg tcgcagccac
    11161 tcgtccagca cgtacacgcg cagacccggc agaccgcggc cgatcacgct gcccggagcc
    11221 gccggctcgg cggccagctc ctggtaggtg acgtggaccg tcgtctcggt gatcccgtac
    11281 atgttcacca agcgcggccc ctgcgggtgc cgctcccacc agcctgccag acgggccggg
    11341 tcgagcgcct caccgccgaa caccaccgcg cgcagcgaag ccagcgcctg cggtgaccgt
    11401 tcctcggtcg ccatcagctg gtagaacgcc gacggcgtct ggctgagcac cgtcacccgc
    11461 tcgcgctcca ggaggtccag gaacgcctcc ggcgaacgcg agaccccgac cggtacgacc
    11521 acggcccggc caccgtggag cagggcgccc cacagttccc acaccgagaa gtcgaaggcg
    11581 aacgagtgga accagctcca cacgtctccc ggcccgaaac cgaggaggct gcgggtctgc
    11641 gccagcatcc ccgtcaccgc ctcgtgcgac acgaccacgc ccttggggcg gcccgtcgac
    11701 ccggacgtgt agatcacgta ggccgggtgg gccggggacg cggccgtccg ctcgtccggg
    11761 cccagcggtc cgcggtcggc agccgccgcg gcggaaccgt ccgccacaac caccggcacc
    11821 ccgaacccgt tcgcccgtgc ggtcagctgc ggcgaggcga ggaccagcgt cgcgcccgcg
    11881 tcctcgagcg tgtacgtcac ccggtcatcg gggtaggccg ggtccagcgg caggtacgcg
    11941 ccgcccgtct tcaccaccgc gaccatggcc accaccaggt cggccgaccg ctcgtgcagc
    12001 aggccgacga ccgactccgg accgacaccg cggtccagca tcaggcgtgc cagccggttc
    12061 gcccgggcgt ccagctgccc gtacgtgacc tccgcaccct ccgctacgac cgcaaccgcg
    12121 tccggcgtcc gcgccgcctg tgcctcgaac agctccagca gcgtcgccgg agccgcgtcg
    12181 accgggtcga cctgccactc cacgagcagc tggtggcgct cggcctcgtc cagtacgtcg
    12241 accccgctga ccggcactcg cggatccgcg gccaccgccg acagcacccg gccgaaccgg
    12301 agcgcgatgc gctccgccga gcccgcgtcg aacaggtccg cggccgccgt caccgcaccc
    12361 cgcagacccg cgggggcccc gtgctcgtcg aacacctcgc ccagcccgaa ggtcaggtcg
    12421 aacttggcag ccgtcgcacc cgcggtgacg cccaccggcg cggcgggcag gtccggcgtc
    12481 gcggaaccgc cgttctgcac gttcagcatc acctggaaca gcgggtgcct ggcacgcgac
    12541 cgcgccggag ccaggtcctc gacgagccgc tcgaagggca cgtcctggtt cgccatcccg
    12601 gacagcgtgg cttcacggac ccgtcccagg acgttgcgga actccgggtc gcccgacagg
    12661 tcggcccgca cgaccagcgt gttgacgaag aagccgacca ggtcgtccag cgccacgtcc
    12721 gtgcgcccgg cgttcgccga gcccatcgga atgtcctggc ccgcgcccag cttggacagc
    12781 aggaccgcca gcgcggactg cagcaccatg ttcatcgtca cgccctcggc gcgcgcgacc
    12841 ttcaccaacc gggcgtgcac ctcggccggg atcacgaccg gcgcgtcgat cccgcgatgg
    12901 gaggcgaccg ccggcctcgg gcggtccacg gggagctcca gctcctcggg gatgccggcg
    12961 agcgcgtcac gccactgggc gatctgacgt gccatcgggc tctcggggtc ctgttcgtcg
    13021 ccgagcagtt cacgctgcca gagggcgtag tcggcgtact gcaccggcag cggcacccat
    13081 tccggcgccc ggccctcacg tcgcgccgtg taggcggtcg ccacgtcccg gctcagcggg
    13141 ccgtccgacc agccgtcacc ggcgatgtgg tggacgacga tcagcagggt gctctcctgc
    13201 ggcccggact cgaacaacca tgcccggatc ggcgcctcgg ccgccaggtc gaacgcccgg
    13261 cccttggcct cggcgatcgc cccgtccagc gcctccggcg ccacctcgac gacgtcgatc
    13321 tcccacgcga ggtcatcgag gtcgatgatc cgctggtagg gctcgccgtc caccgtcgcg
    13381 aacaccgtcc gcagcacctc gtggcgcccg atgacgtccc gcagcgcctc ccccagcgcc
    13441 tcccggtcca cgtctcccgg cagcgggagc aggatcggaa tgtgataggc ggtgctgccc
    13501 tccaactggt cgatgaacca cagccgctgc tgggcgaacg agagcgggat ccgctcgggg
    13561 cgctccctcg cctccagcgc gagccgcgcc tcgccggcac cggccaggcg ggccgccatc
    13621 gcggccacgg tgggcgcttc gaagaccgcc tgcagcggca cttcgacccc catgaccgcc
    13681 cggatccggc tgaccagtcg gacggcgagc agggagtgac cgccgagttc gaagaagtcg
    13741 tcaccgactc cgacgccctc cacgcccagc acctgttcga acgctgcaca cagcagggcc
    13801 tcctgggggc tcgcgggccc tcggtcggcg ctgccggtga gttcgggggc gggcagggcc
    13861 ttgcggtcga gcttcccgtt cccggtcagc ggcagcgcct ccagcaccac cacggcggac
    13921 gggaccatgt actccggcag ccgaccttc
//
