LOCUS       NZ_BMVL01000032        18572 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence32, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000032
VERSION     NZ_BMVL01000032.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 18572)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 18572
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000032.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18572
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     gene            <1..3659
                     /locus_tag="IE257_RS37290"
     source          1..18572
                     /culture_collection="JCM:4726"
                     /db_xref="taxon:1895"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces avidinii"
                     /strain="JCM 4726"
                     /submitter_seqid="sequence32"
                     /type_material="type strain of Streptomyces avidinii"
     cand_cluster    1..18572
                     /SMILES="C(CC)=CC([*])C(-O)C=CC(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18572
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[5445:>16296](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5446..>16296)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     CDS_motif       <7..77
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0001"
                     /evalue="1.80E-07"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="IE257_RS37290"
                     /protein_end="24"
                     /protein_start="0"
                     /score="23.8"
                     /tool="antismash"
                     /translation="EVAAACVAGGLSLEDGARVAAVRS"
     aSDomain        <7..620
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: False, scaffold matched
                     GHGE: False"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37290_PKS_AT.1"
                     /evalue="1.00E-65"
                     /label="IE257_RS37290_PKS_AT.1"
                     /locus_tag="IE257_RS37290"
                     /protein_end="205"
                     /protein_start="0"
                     /score="214.0"
                     /specificity="substrate consensus: emal"
                     /specificity="PKS signature: (unknown)"
                     /specificity="Minowa: emal"
                     /tool="antismash"
                     /translation="EVAAACVAGGLSLEDGARVAAVRSRLVLEKLSGKGGMVSVSLPVT
                     EVEERIASFDGRIGVAAVNGPASVVVSGEPDALDELLASCEAEGVRARRIAVDYASHSA
                     QVDALNEDLLRELADISPRSSSVAFHSTVSGEQMDTAGLDARYWLRNMRETVAFEGAVR
                     AALGEGHRTLLEISPHPVLTMAVQEAIDSAGVTAHSSGSLRR"
     aSModule        <7..3389
                     /complete
                     /domains="nrpspksdomains_IE257_RS37290_PKS_AT.1"
                     /domains="nrpspksdomains_IE257_RS37290_PKS_DH.1"
                     /domains="nrpspksdomains_IE257_RS37290_PKS_KR.1"
                     /domains="nrpspksdomains_IE257_RS37290_PKS_PP.1"
                     /locus_tags="IE257_RS37290"
                     /monomer_pairings="emal -> ccemal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS             <5..3659
                     /NRPS_PKS="Domain: PKS_AT (0-205). E-value: 1e-65. Score:
                     214.0. Matches aSDomain:
                     nrpspksdomains_IE257_RS37290_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (274-438). E-value: 1.7e-57.
                     Score: 186.4. Matches aSDomain:
                     nrpspksdomains_IE257_RS37290_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (770-949). E-value: 1.7e-56.
                     Score: 183.0. Matches aSDomain:
                     nrpspksdomains_IE257_RS37290_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1043-1128). E-value: 6.6e-30.
                     Score: 95.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS37290_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (1142-1202). E-value:
                     3.3e-09. Score: 29.5. Matches aSDomain:
                     nrpspksdomains_IE257_RS37290_PKS_Docking_Cterm.1"
                     /codon_start=3
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984325.1"
                     /locus_tag="IE257_RS37290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_229920903.1"
                     /sec_met_domain="PKS_AT (E-value: 6.7e-67, bitscore: 214.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.3e-60, bitscore:
                     191.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.1e-16, bitscore:
                     49.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="EVAAACVAGGLSLEDGARVAAVRSRLVLEKLSGKGGMVSVSLPVT
                     EVEERIASFDGRIGVAAVNGPASVVVSGEPDALDELLASCEAEGVRARRIAVDYASHSA
                     QVDALNEDLLRELADISPRSSSVAFHSTVSGEQMDTAGLDARYWLRNMRETVAFEGAVR
                     AALGEGHRTLLEISPHPVLTMAVQEAIDSAGVTAHSSGSLRREDGGTGRLLNSLAEAYV
                     AGAPVDWTKAFAGAGARRVDLPTYAFQRQRYWLRLAASGSGDVTAAGLGNPGHPLLGAS
                     VEPAETDGLVLTGRISLRDHPWLADHRVMGAVPLPGTAFVELAVVAGDLVECPGIEELT
                     MEAALLLPESGALDLQLTVSAPDGTGRREIGFFARTDDDITAAGWTRHGSGVLCPAAPV
                     PDAEPAAWPPPGAEPVELAGLYEQSPDSPFAYGPAFHGLRAAWSRGREVFAEVQLPQEL
                     HEQASEYLLHPALLDAALHAVGLGELLDSGGQPLRPFAWNAVSLHASGATTLRVTLSPA
                     GANAVSLRAADGTGAPVVTVGSLMLRPVDVTEPAAGRSAVHPSLLSLAWTPLPLPAADA
                     APWAVLGAAPAGRPSWTGSDVPPQQHADVAALAASVAGGGPVPQFAVLDLTVGEPSGPE
                     LLTATRDRAQRVLDAARAWVAEDLDERLAPVTLVVATRDAVGTSAQDRTAGLGSAPLWG
                     LVRSVQSENPGRFVLLDTDGLPASWQALPAALATGEAEIALRSGTALVPRLDRMPAAEA
                     TDTELLPGTALDELDPAGTVLVTGATGGLGSLVATHLAERHGVRNLLLLSRRGPEAEGA
                     TELVRQLEKHGATATLAACDAADRDALAAVLAAIPAEQPLIAVVHCAGTAENALLATLD
                     PGMIDRVFRAKVDAAVHLHELTEGMDLSAFVLFSSIAGTLGGTGQGNYAAANTFLDSLA
                     RHRRARGLAATSLAWGLWATERGMGGGLTEAASAGTPMRGVRALPTEEGLALFDLGWRS
                     AEPVLFPARLGGAALRAQASAGTLPPVLRGLFRTSSRRTAGTETQDAGTQLRRRLAEMM
                     PVERQETLLALVRGRIAAVLGHGSPDQIEADRPFRDLGFTSLTAVELRNRLNAATGLRL
                     PVSLVFDYPTLDALVPLLLGKLVPDGGPAAGQEKDDEEAEVRRVLACIPLSRLRETGLL
                     SSLLELTGDRGETKQEASDRSDEIKSMDVAALLAMARTTSAADDASPSAHEA"
     CDS_motif       186..224
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0002"
                     /evalue="5.60E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE257_RS37290"
                     /protein_end="73"
                     /protein_start="60"
                     /score="13.2"
                     /tool="antismash"
                     /translation="AAVNGPASVVVSG"
     CDS_motif       294..326
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0003"
                     /evalue="4.30E-04"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="IE257_RS37290"
                     /protein_end="107"
                     /protein_start="96"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VDYASHSAQVD"
     CDS_motif       432..479
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0004"
                     /evalue="3.40E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="IE257_RS37290"
                     /protein_end="158"
                     /protein_start="142"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LDARYWLRNMRETVAF"
     aSDomain        828..1319
                     /ASF="catalytic triad H,G,P found: False"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37290_PKS_DH.1"
                     /evalue="1.70E-57"
                     /label="IE257_RS37290_PKS_DH.1"
                     /locus_tag="IE257_RS37290"
                     /protein_end="438"
                     /protein_start="274"
                     /score="186.4"
                     /tool="antismash"
                     /translation="HPLLGASVEPAETDGLVLTGRISLRDHPWLADHRVMGAVPLPGTA
                     FVELAVVAGDLVECPGIEELTMEAALLLPESGALDLQLTVSAPDGTGRREIGFFARTDD
                     DITAAGWTRHGSGVLCPAAPVPDAEPAAWPPPGAEPVELAGLYEQSPDSPFAYGPAFHG
                     L"
     CDS_motif       912..986
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0005"
                     /evalue="2.80E-08"
                     /label="PKSI-DH_m2"
                     /locus_tag="IE257_RS37290"
                     /protein_end="327"
                     /protein_start="302"
                     /score="26.3"
                     /tool="antismash"
                     /translation="WLADHRVMGAVPLPGTAFVELAVVA"
     aSDomain        2316..2852
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37290_PKS_KR.1"
                     /evalue="1.70E-56"
                     /label="IE257_RS37290_PKS_KR.1"
                     /locus_tag="IE257_RS37290"
                     /protein_end="949"
                     /protein_start="770"
                     /score="183.0"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GTVLVTGATGGLGSLVATHLAERHGVRNLLLLSRRGPEAEGATEL
                     VRQLEKHGATATLAACDAADRDALAAVLAAIPAEQPLIAVVHCAGTAENALLATLDPGM
                     IDRVFRAKVDAAVHLHELTEGMDLSAFVLFSSIAGTLGGTGQGNYAAANTFLDSLARHR
                     RARGLAATSLAWGLWA"
     CDS_motif       2319..2420
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0006"
                     /evalue="3.80E-09"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE257_RS37290"
                     /protein_end="805"
                     /protein_start="771"
                     /score="29.2"
                     /tool="antismash"
                     /translation="TVLVTGATGGLGSLVATHLAERHGVRNLLLLSRR"
     CDS_motif       2703..2807
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37290_0007"
                     /evalue="5.30E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE257_RS37290"
                     /protein_end="934"
                     /protein_start="899"
                     /score="67.2"
                     /tool="antismash"
                     /translation="AFVLFSSIAGTLGGTGQGNYAAANTFLDSLARHRR"
     aSDomain        3135..3389
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37290_PKS_PP.1"
                     /evalue="6.60E-30"
                     /label="IE257_RS37290_PKS_PP.1"
                     /locus_tag="IE257_RS37290"
                     /protein_end="1128"
                     /protein_start="1043"
                     /score="95.3"
                     /tool="antismash"
                     /translation="LAEMMPVERQETLLALVRGRIAAVLGHGSPDQIEADRPFRDLGFT
                     SLTAVELRNRLNAATGLRLPVSLVFDYPTLDALVPLLLGK"
     aSDomain        3432..3611
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37290_PKS_Docking_Cterm.
                     1"
                     /evalue="3.30E-09"
                     /label="IE257_RS37290_PKS_Docking_Cterm.1"
                     /locus_tag="IE257_RS37290"
                     /protein_end="1202"
                     /protein_start="1142"
                     /score="29.5"
                     /tool="antismash"
                     /translation="DEEAEVRRVLACIPLSRLRETGLLSSLLELTGDRGETKQEASDRS
                     DEIKSMDVAALLAMA"
     misc_feature    3747..3762
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            3803..5017
                     /locus_tag="IE257_RS37295"
                     /old_locus_tag="GCM10010343_76180"
     CDS             3803..5017
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984326.1"
                     /locus_tag="IE257_RS37295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_76180"
                     /product="cytochrome P450"
                     /protein_id="WP_189974491.1"
                     /sec_met_domain="p450 (E-value: 2.3e-27, bitscore: 83.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESTAEPIPFPFPDPSFIGDLPPELAEIRDGDSVVEVKFPDGMG
                     AWLVTKHADIRKVLVDPRFSSKVMAAAAAAMSETETGKLMNESLVGMDAPEHTRLRKLV
                     SRAFTARRMELMRPRVAQLVAEYLDEMETQPQPVDLVKNFALPLPVRVICELLGVPAGD
                     QDTFHAWSNALLGDWQQVVEKEAATVSLVNYFTELVTAKREQPADDLMSDLIRISEDDE
                     TLTTREIVALSIGILSAGHETTANQIGMFVLTLLHNPDELAKLRANPEAVPQAVEELLR
                     FVPLTTTGGIIPRLTTAPVELSDGRTLPAGVVVMPAVATGNRDPELFEDGERLNLSRQP
                     NPHLAFGAGIHHCLGAQLARIELQEALAALLARFPDLALGVPESELRLKPASIVRGLES
                     LPLTW"
     gene            complement(5446..>16296)
                     /locus_tag="IE257_RS37300"
                     /old_locus_tag="GCM10010343_76200"
                     /pseudo=""
     CDS             complement(5446..>16296)
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (0-25). E-value:
                     3.8e-09. Score: 27.9. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_Docking_Nterm.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (30-454). E-value:
                     1.9e-180. Score: 592.2. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (566-863). E-value: 2e-104.
                     Score: 341.1. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1182-1361). E-value: 7.6e-61.
                     Score: 197.2. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1467-1540). E-value: 1.5e-31.
                     Score: 100.5. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_ACP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (1560-1983). E-value:
                     6.6e-176. Score: 577.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_KS.2"
                     /NRPS_PKS="Domain: PKS_AT (2093-2386). E-value: 1.9e-107.
                     Score: 351.0. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_AT.2"
                     /NRPS_PKS="Domain: PKS_DH (2455-2622). E-value: 6.3e-63.
                     Score: 204.0. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (2947-3126). E-value: 5.7e-62.
                     Score: 200.8. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_PKS_KR.2"
                     /NRPS_PKS="Domain: ACP (3233-3305). E-value: 4.8e-30.
                     Score: 95.7. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_ACP.2"
                     /NRPS_PKS="Domain: Thioesterase (3413-3611). E-value:
                     1.5e-25. Score: 82.9. Matches aSDomain:
                     nrpspksdomains_IE257_RS37300_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984327.1"
                     /locus_tag="IE257_RS37300"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_76200"
                     /product="type I polyketide synthase"
                     /pseudo=""
                     /sec_met_domain="mod_KS (E-value: 4e-226, bitscore: 738.8,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.9e-90, bitscore:
                     289.9, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.3e-09,
                     bitscore: 24.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.1e-17, bitscore:
                     52.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.2e-108, bitscore:
                     351.0, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.9e-67, bitscore:
                     214.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.8e-16, bitscore:
                     49.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRTYLRRVTAELQQTRQQLQDSQDRAREPLAVVGMACRLPGGVDS
                     PEQLWHMVVNGVDAVGGFPDDRGWDLSSLFDSDPDRPGTTYTREGAFLHGAGDFDAGFF
                     GISPREAMTMDPQQRLLLETSWEALERAGIDPVSLRGSRTGVFVGGTAIEHTVKLMNSP
                     TDQGYAITGGSASIMSGRVSYVLGLEGPAVTVDTACSSSLVALHSAAQSLRQGDCSLAL
                     AAGVAVMATSSAFVTFARQRGLAADGRCKAFSDEADGIGWGEGAAVVLLERLSDARRNG
                     HPVLAVIRGSAVNQDGASNGLSAPNGPSQQRVIRQAVANAGLTLADVDMVEAHGTGTTL
                     GDPIEAQALLATYGQDRHDGRPLWLGSLKSNIAHTQAVSGVAGVIKSVLALQHGVLPKT
                     LHAENPSTQIDWTEGEVELLTTTRDWPETGRPRRAGVSSFGISGTNAHVVLEQAPEAEP
                     VEAQPADAAEPPLSTSPAVLPWLISGNTEAALRDQAARLREYLHPKDGLDIADVGFSLL
                     SSRSQLAHRAVLFAEAGGTLPEGLEALAEGRDLPGLVRGTGDVGSGVVFVFPGQGSQWV
                     GMGRELWGSSAVFAESMVACERALSPLVDWSLRDVVFREADDPLWGRVDVVQPVLWAVM
                     VSLAAVWRSFGVEPAAVIGHSQGEVAAACVAGGLSLEDGARVAAVRSRLVLEKLSGKGG
                     MVSVSLPVTEVEERIAPFDGRIGVAAVNGPASVVVSGEPDALDELLASCEVEGVRARRI
                     AVDYASHSAQVDVLNEDLLRELAEIRPQSSSVAFYSTVSGERMDTAGLDAGYWVRNLRE
                     RVQFEPVTRLLAEQEYGVFVESSPHPVLTMAIQETQESVLGAGAAIGSLRREDGGAQRF
                     LASLAEAYVAGAPVDWKQLFTGSEARRVDLPTYAFQHQRYWIADVVAPVAEAAVDPVDA
                     AFWGAVERADVEGVAQLVDGGAVDAWEPVVPALSAWRKGRRERSVLDSWRYRTVWRSVT
                     VPSSGRLDGTWLLVTSGTGAPAEEVRDALVAAGAEVVVLEAEAGLDRAELAARLSATPD
                     VAGVVSLLGWDEESALTATLSLLQGLADVAATGRLWVLTKGAAAVGSADPVSPVQTQLW
                     ALGQVAGLEQPGTWGGLVDVPEVWDERVASGFTGVLAAGEGEDQVAVRSSGAYARRLVR
                     APLGGSPVPVRDWNPRGTVLITGGTGGIGAHLARWLAKDGAEHLLLLSRRGEAAEGAAE
                     LAAELRGLGAEVSVVACDVTDRDALAAIIEAVPAEHPLTAVFHTAGISGYAELALATPE
                     HFEGIFSAKVQGARHLDSLTADLPLDAFVLFSSGAAVWGSAGTGAYAAANAYLDGLAWD
                     RRSRGLTATSVSWGGWQDTGMAVDGTAEQLSRRGVGQMEPSLAIEALRQAIEQDETALT
                     VTDMDWERFTPGYTMARRRPLIEDIPEVSRVLSEDSVVPAEDESSGSALREALVGLTVP
                     EQYDRLLELVRTEAAAVLTHQTTDEITAHRPFRDLGFDSLTAMELRNRLNAATGLRFPA
                     TIVFDYPTPQRIANHLHEQLFDGSAATAALPALRATDDDPIVIVGMACRFPGGVRGPED
                     LWQLLVENRDEMTDFPADRGWQGLAMNDFIAESGSARQGAFLAEAADFDAAFFDISPRE
                     ALSMDPQQRLLLEISWETLERAGYDPSALRGSRTGVFVGGTPQEYTTVLMSSTEAAGGY
                     ALTGASGSVMSGRVAYALGLEGPAVTVDTACSSSLVTLHLAAQALRNGECDLALAGGVT
                     VMATPGAFVEFSRQGGLAADGRAKAFAAAADGTGWGEGVGMLAVQRLSDAVRDGRPVLA
                     VLRGSAVNSDGASNGLTAPNGPSQQRVIRQALASAGLNTADVDMLEAHGTGTALGDPIE
                     AQALLATYGQDRPADRPLLLGSVKSNIGHTQYAAGVAGVIKSVLALKHSVLPKTLHVDE
                     PTPEVDWSTGMVELLTGNREWPQTGRPRRAGVSAFGISGTNAHIILEQAPEETGTEAQE
                     STADAAGSEEVAPVVPWVISARSEDGLRDQARRLADHLREQDVRPLDVGFSLAATRATL
                     EHRAVLVGADRDELLNRLAALAEGGSPAGAPRGVAGDGKTAFLFTGQGAQRQGMGRELY
                     DAHPVFAEAFDAVCAQLDTLLDQPVKDVVFADGTALSRTVFTQAGLFAFEVALYELVSS
                     WGVRPDVLLGHSIGELAAAYVAGVWSLPDACRIVAARGRLMQALPSGGAMLAVQAAPDE
                     LPELPEGVSVAAVNGPRSVVLSGDEEPVRALADVFREQGRRTKELTVSHAFHSARMEPM
                     LAAFGEVLATAEFRAPRIPVVSNLTGEIAGDELTTPDYWVRHVRGTVRFADGVATAMSR
                     GVDTFLELGPGGELTAMAEETLDHHGHAGTRTTCVPALRREQPEAASLALALGRIHVAG
                     TPVDWKALFAGTGARTVGLPTYAFQHKRYWLDSMSTSAGDPASIGLTATGHPLLGAGVA
                     LPESDGFLFTGRLSLAAQPWIAHHAMLGTALLPGTAFVELALRAGSQVGCELIDELTLE
                     APLVLGEQGGRAIQILVGGLDESGRRPISLYSRADGDGDDGQWTRHASGLLADGVAAAE
                     AAPEPVTVWPPAGATEIPVEDFYPNLADAGFAYGPVFQGLRALWDKDGELFAEVRLPEE
                     ADAEGSGYGVHPALLDAALQPLALGILGLAPGREPIKGGMPFAWTGVRLHATHASVVRV
                     HLAPAGRSEVSVLVTDTSGLPVATVDSLTMRDPALEQFIGTGSAPRQDSLFTLTWAPVP
                     LGSRQISGEWAMLGFDPLSLRPRLVEAGLSGTPYLDPQSLLDTVESGAPAPAVVAMTCF
                     GGDQGGVLAATHHAAHRVLETVQHWLSDERLAASKLLLLTRGAVSALDTDRTTDIGASA
                     VWGLVRTAQSEHPDRIVLIDLDDDAASYRALPAALGTGEPQLALRAGAASAPRLARNTA
                     APEGAGSFGPEGTVLITGGTGALGAVVARHLVTEHGVRHLVLASRSGADAPGAADLIAE
                     LGELGAEARLAACDVADRTALEALLADVPAGQPLAGVVHTAGVLDDGTIESLTPERIDT
                     VLRAKADAAWHLHELTRDAELRAFVLFSSAAGMLGSQGQGNYAAANSFLDALAVHRHEA
                     GLAGTSLAWGWWEQPGGMGAELGRAERARMARGGVTAFTAETGMAAFDAALGVADEAVL
                     VPMRLNTTVARPTGEQQVPPLLRGLVRAPQRRAARSDTRAASRLHEQLAAAAGADRVAV
                     LAELVRAEVAQVLGHSGAEAIEDGQGFAELGFDSLTSVELRNRLNELTGLRLASTVVFD
                     HPTPTALAAELSEQLKGSVAPAAASAAPVVAAQQPEQAEAAADTSGIAVINGVEAMYRR
                     AVEIGRLDIGHSVLRNSVDLRENFSDPADVRKGPGLVRLGAGDAFPKIIGFPSQSVWAS
                     NQELVALAEPLRGIRDVWSLMLPGFVTGEPVADSVDAAAAYAVRRIEELTEGTPFVLTG
                     RSSGGRVAHEVTARLEERGIYPQGLVLIDSYLAGYDQTSYIVPVMEGKALELEKDFGRM
                     TGNRLTAMSAYFALFEHWQPKEIKTPTLLVRASECFGVEPGEVGPPPEKWQAVWPLEHD
                     AIDVPGNHYTMLEGNGDVTAAAIHEWLLKQR"
     aSDomain        complement(5461..6054)
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_Thioesterase.1"
                     /evalue="1.50E-25"
                     /label="IE257_RS37300_Thioesterase.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="3611"
                     /protein_start="3413"
                     /score="82.9"
                     /tool="antismash"
                     /translation="ALAEPLRGIRDVWSLMLPGFVTGEPVADSVDAAAAYAVRRIEELT
                     EGTPFVLTGRSSGGRVAHEVTARLEERGIYPQGLVLIDSYLAGYDQTSYIVPVMEGKAL
                     ELEKDFGRMTGNRLTAMSAYFALFEHWQPKEIKTPTLLVRASECFGVEPGEVGPPPEKW
                     QAVWPLEHDAIDVPGNHYTMLEGNGDVTAAAIHEW"
     aSModule        complement(5461..11613)
                     /complete
                     /domains="nrpspksdomains_IE257_RS37300_PKS_KS.2"
                     /domains="nrpspksdomains_IE257_RS37300_PKS_AT.2"
                     /domains="nrpspksdomains_IE257_RS37300_PKS_DH.1"
                     /domains="nrpspksdomains_IE257_RS37300_PKS_KR.2"
                     /domains="nrpspksdomains_IE257_RS37300_ACP.2"
                     /domains="nrpspksdomains_IE257_RS37300_Thioesterase.1"
                     /final_module
                     /locus_tags="IE257_RS37300"
                     /monomer_pairings="mal -> ccmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(5848..5910)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0030"
                     /evalue="1.60E-03"
                     /label="NRPS-te1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="3482"
                     /protein_start="3461"
                     /score="11.1"
                     /tool="antismash"
                     /translation="PFVLTGRSSGGRVAHEVTARL"
     aSDomain        complement(6379..6594)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_ACP.2"
                     /evalue="4.80E-30"
                     /label="IE257_RS37300_ACP.2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="3305"
                     /protein_start="3233"
                     /score="95.7"
                     /tool="antismash"
                     /translation="ELVRAEVAQVLGHSGAEAIEDGQGFAELGFDSLTSVELRNRLNEL
                     TGLRLASTVVFDHPTPTALAAELSEQL"
     aSDomain        complement(6916..7452)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N found: True"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_KR.2"
                     /evalue="5.70E-62"
                     /label="IE257_RS37300_PKS_KR.2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="3126"
                     /protein_start="2947"
                     /score="200.8"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLITGGTGALGAVVARHLVTEHGVRHLVLASRSGADAPGAADL
                     IAELGELGAEARLAACDVADRTALEALLADVPAGQPLAGVVHTAGVLDDGTIESLTPER
                     IDTVLRAKADAAWHLHELTRDAELRAFVLFSSAAGMLGSQGQGNYAAANSFLDALAVHR
                     HEAGLAGTSLAWGWWE"
     CDS_motif       complement(6961..7071)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0029"
                     /evalue="5.40E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE257_RS37300"
                     /protein_end="3111"
                     /protein_start="3074"
                     /score="60.8"
                     /tool="antismash"
                     /translation="LRAFVLFSSAAGMLGSQGQGNYAAANSFLDALAVHRH"
     CDS_motif       complement(7093..7122)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0028"
                     /evalue="4.10E-01"
                     /label="PKSI-KR_m3"
                     /locus_tag="IE257_RS37300"
                     /protein_end="3067"
                     /protein_start="3057"
                     /score="4.7"
                     /tool="antismash"
                     /translation="AKADAAWHLH"
     CDS_motif       complement(7348..7449)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0027"
                     /evalue="3.20E-11"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2982"
                     /protein_start="2948"
                     /score="35.8"
                     /tool="antismash"
                     /translation="TVLITGGTGALGAVVARHLVTEHGVRHLVLASRS"
     aSDomain        complement(8428..8928)
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_DH.1"
                     /evalue="6.30E-63"
                     /label="IE257_RS37300_PKS_DH.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2622"
                     /protein_start="2455"
                     /score="204.0"
                     /tool="antismash"
                     /translation="HPLLGAGVALPESDGFLFTGRLSLAAQPWIAHHAMLGTALLPGTA
                     FVELALRAGSQVGCELIDELTLEAPLVLGEQGGRAIQILVGGLDESGRRPISLYSRADG
                     DGDDGQWTRHASGLLADGVAAAEAAPEPVTVWPPAGATEIPVEDFYPNLADAGFAYGPV
                     FQGL"
     CDS_motif       complement(8770..8844)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0026"
                     /evalue="1.10E-05"
                     /label="PKSI-DH_m2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2508"
                     /protein_start="2483"
                     /score="18.0"
                     /tool="antismash"
                     /translation="WIAHHAMLGTALLPGTAFVELALRA"
     aSDomain        complement(9136..10014)
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_AT.2"
                     /evalue="1.90E-107"
                     /label="IE257_RS37300_PKS_AT.2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2386"
                     /protein_start="2093"
                     /score="351.0"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGAQRQGMGRELYDAHPVFAEAFDAVCAQLDTLLDQPVKDV
                     VFADGTALSRTVFTQAGLFAFEVALYELVSSWGVRPDVLLGHSIGELAAAYVAGVWSLP
                     DACRIVAARGRLMQALPSGGAMLAVQAAPDELPELPEGVSVAAVNGPRSVVLSGDEEPV
                     RALADVFREQGRRTKELTVSHAFHSARMEPMLAAFGEVLATAEFRAPRIPVVSNLTGEI
                     AGDELTTPDYWVRHVRGTVRFADGVATAMSRGVDTFLELGPGGELTAMAEETLDHHGHA
                     GTRTTCVPALRR"
     CDS_motif       complement(9286..9321)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0025"
                     /evalue="3.50E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2336"
                     /protein_start="2324"
                     /score="14.0"
                     /tool="antismash"
                     /translation="YWVRHVRGTVRF"
     CDS_motif       complement(9541..9579)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0024"
                     /evalue="7.70E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2251"
                     /protein_start="2238"
                     /score="12.7"
                     /tool="antismash"
                     /translation="AAVNGPRSVVLSG"
     CDS_motif       complement(9661..9783)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0023"
                     /evalue="1.60E-24"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2211"
                     /protein_start="2170"
                     /score="78.3"
                     /tool="antismash"
                     /translation="GVRPDVLLGHSIGELAAAYVAGVWSLPDACRIVAARGRLMQ"
     CDS_motif       complement(9799..9840)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0022"
                     /evalue="1.20E+01"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2165"
                     /protein_start="2151"
                     /score="0.1"
                     /tool="antismash"
                     /translation="TQAGLFAFEVALYE"
     CDS_motif       complement(9964..10017)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0021"
                     /evalue="2.00E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="2110"
                     /protein_start="2092"
                     /score="17.0"
                     /tool="antismash"
                     /translation="FLFTGQGAQRQGMGRELY"
     aSDomain        complement(10345..11613)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_KS.2"
                     /domain_subtypes="Modular-KS"
                     /evalue="6.60E-176"
                     /label="IE257_RS37300_PKS_KS.2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1983"
                     /protein_start="1560"
                     /score="577.3"
                     /tool="antismash"
                     /translation="IVIVGMACRFPGGVRGPEDLWQLLVENRDEMTDFPADRGWQGLAM
                     NDFIAESGSARQGAFLAEAADFDAAFFDISPREALSMDPQQRLLLEISWETLERAGYDP
                     SALRGSRTGVFVGGTPQEYTTVLMSSTEAAGGYALTGASGSVMSGRVAYALGLEGPAVT
                     VDTACSSSLVTLHLAAQALRNGECDLALAGGVTVMATPGAFVEFSRQGGLAADGRAKAF
                     AAAADGTGWGEGVGMLAVQRLSDAVRDGRPVLAVLRGSAVNSDGASNGLTAPNGPSQQR
                     VIRQALASAGLNTADVDMLEAHGTGTALGDPIEAQALLATYGQDRPADRPLLLGSVKSN
                     IGHTQYAAGVAGVIKSVLALKHSVLPKTLHVDEPTPEVDWSTGMVELLTGNREWPQTGR
                     PRRAGVSAFGISGTNAHIILEQAP"
     CDS_motif       complement(10567..10611)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0020"
                     /evalue="6.50E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1909"
                     /protein_start="1894"
                     /score="9.4"
                     /tool="antismash"
                     /translation="GSVKSNIGHTQYAAG"
     CDS_motif       complement(10672..10716)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0019"
                     /evalue="1.80E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1874"
                     /protein_start="1859"
                     /score="10.9"
                     /tool="antismash"
                     /translation="LEAHGTGTALGDPIE"
     CDS_motif       complement(10912..10950)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0018"
                     /evalue="6.80E-01"
                     /label="PKSI-KS_m4"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1794"
                     /protein_start="1781"
                     /score="4.0"
                     /tool="antismash"
                     /translation="FAAAADGTGWGEG"
     CDS_motif       complement(11095..11139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0017"
                     /evalue="7.40E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1733"
                     /protein_start="1718"
                     /score="18.0"
                     /tool="antismash"
                     /translation="GPAVTVDTACSSSLV"
     CDS_motif       complement(11341..11367)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0016"
                     /evalue="6.80E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1651"
                     /protein_start="1642"
                     /score="6.5"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(11674..11892)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_ACP.1"
                     /evalue="1.50E-31"
                     /label="IE257_RS37300_ACP.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1540"
                     /protein_start="1467"
                     /score="100.5"
                     /tool="antismash"
                     /translation="LELVRTEAAAVLTHQTTDEITAHRPFRDLGFDSLTAMELRNRLNA
                     ATGLRFPATIVFDYPTPQRIANHLHEQL"
     aSModule        complement(11674..16203)
                     /complete
                     /domains="nrpspksdomains_IE257_RS37300_PKS_KS.1"
                     /domains="nrpspksdomains_IE257_RS37300_PKS_AT.1"
                     /domains="nrpspksdomains_IE257_RS37300_PKS_KR.1"
                     /domains="nrpspksdomains_IE257_RS37300_ACP.1"
                     /locus_tags="IE257_RS37300"
                     /monomer_pairings="pk -> pk"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(12211..12747)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_KR.1"
                     /evalue="7.60E-61"
                     /label="IE257_RS37300_PKS_KR.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1361"
                     /protein_start="1182"
                     /score="197.2"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="GTVLITGGTGGIGAHLARWLAKDGAEHLLLLSRRGEAAEGAAELA
                     AELRGLGAEVSVVACDVTDRDALAAIIEAVPAEHPLTAVFHTAGISGYAELALATPEHF
                     EGIFSAKVQGARHLDSLTADLPLDAFVLFSSGAAVWGSAGTGAYAAANAYLDGLAWDRR
                     SRGLTATSVSWGGWQD"
     CDS_motif       complement(12259..12369)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0015"
                     /evalue="4.80E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1345"
                     /protein_start="1308"
                     /score="51.3"
                     /tool="antismash"
                     /translation="LDAFVLFSSGAAVWGSAGTGAYAAANAYLDGLAWDRR"
     CDS_motif       complement(12391..12420)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0014"
                     /evalue="6.00E-01"
                     /label="PKSI-KR_m3"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1301"
                     /protein_start="1291"
                     /score="4.3"
                     /tool="antismash"
                     /translation="AKVQGARHLD"
     CDS_motif       complement(12646..12744)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0013"
                     /evalue="1.70E-14"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1216"
                     /protein_start="1183"
                     /score="46.3"
                     /tool="antismash"
                     /translation="TVLITGGTGGIGAHLARWLAKDGAEHLLLLSRR"
     CDS_motif       complement(13210..13290)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0012"
                     /evalue="2.10E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="1028"
                     /protein_start="1001"
                     /score="-2.0"
                     /tool="antismash"
                     /translation="LVTSGTGAPAEEVRDALVAAGAEVVVL"
     aSDomain        complement(13705..14595)
                     /ASF="Methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_AT.1"
                     /evalue="2.00E-104"
                     /label="IE257_RS37300_PKS_AT.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="863"
                     /protein_start="566"
                     /score="341.1"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: emal"
                     /tool="antismash"
                     /translation="VFPGQGSQWVGMGRELWGSSAVFAESMVACERALSPLVDWSLRDV
                     VFREADDPLWGRVDVVQPVLWAVMVSLAAVWRSFGVEPAAVIGHSQGEVAAACVAGGLS
                     LEDGARVAAVRSRLVLEKLSGKGGMVSVSLPVTEVEERIAPFDGRIGVAAVNGPASVVV
                     SGEPDALDELLASCEVEGVRARRIAVDYASHSAQVDVLNEDLLRELAEIRPQSSSVAFY
                     STVSGERMDTAGLDAGYWVRNLRERVQFEPVTRLLAEQEYGVFVESSPHPVLTMAIQET
                     QESVLGAGAAIGSLRR"
     CDS_motif       complement(13846..13893)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0011"
                     /evalue="1.70E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="IE257_RS37300"
                     /protein_end="816"
                     /protein_start="800"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LDAGYWVRNLRERVQF"
     CDS_motif       complement(13999..14031)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0010"
                     /evalue="1.50E-03"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="IE257_RS37300"
                     /protein_end="765"
                     /protein_start="754"
                     /score="11.4"
                     /tool="antismash"
                     /translation="VDYASHSAQVD"
     CDS_motif       complement(14101..14139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0009"
                     /evalue="1.90E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE257_RS37300"
                     /protein_end="731"
                     /protein_start="718"
                     /score="11.6"
                     /tool="antismash"
                     /translation="AAVNGPASVVVSG"
     CDS_motif       complement(14248..14358)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0008"
                     /evalue="1.20E-16"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="IE257_RS37300"
                     /protein_end="682"
                     /protein_start="645"
                     /score="52.6"
                     /tool="antismash"
                     /translation="GVEPAAVIGHSQGEVAAACVAGGLSLEDGARVAAVRS"
     CDS_motif       complement(14362..14427)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0007"
                     /evalue="3.10E-09"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="644"
                     /protein_start="622"
                     /score="29.1"
                     /tool="antismash"
                     /translation="RVDVVQPVLWAVMVSLAAVWRS"
     CDS_motif       complement(14548..14601)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0006"
                     /evalue="3.90E-09"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="582"
                     /protein_start="564"
                     /score="28.2"
                     /tool="antismash"
                     /translation="VFVFPGQGSQWVGMGREL"
     aSDomain        complement(14932..16203)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="1.90E-180"
                     /label="IE257_RS37300_PKS_KS.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="454"
                     /protein_start="30"
                     /score="592.2"
                     /tool="antismash"
                     /translation="AVVGMACRLPGGVDSPEQLWHMVVNGVDAVGGFPDDRGWDLSSLF
                     DSDPDRPGTTYTREGAFLHGAGDFDAGFFGISPREAMTMDPQQRLLLETSWEALERAGI
                     DPVSLRGSRTGVFVGGTAIEHTVKLMNSPTDQGYAITGGSASIMSGRVSYVLGLEGPAV
                     TVDTACSSSLVALHSAAQSLRQGDCSLALAAGVAVMATSSAFVTFARQRGLAADGRCKA
                     FSDEADGIGWGEGAAVVLLERLSDARRNGHPVLAVIRGSAVNQDGASNGLSAPNGPSQQ
                     RVIRQAVANAGLTLADVDMVEAHGTGTTLGDPIEAQALLATYGQDRHDGRPLWLGSLKS
                     NIAHTQAVSGVAGVIKSVLALQHGVLPKTLHAENPSTQIDWTEGEVELLTTTRDWPETG
                     RPRRAGVSSFGISGTNAHVVLEQAP"
     CDS_motif       complement(15154..15198)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0005"
                     /evalue="4.10E-01"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE257_RS37300"
                     /protein_end="380"
                     /protein_start="365"
                     /score="4.5"
                     /tool="antismash"
                     /translation="GSLKSNIAHTQAVSG"
     CDS_motif       complement(15259..15306)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0004"
                     /evalue="7.80E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE257_RS37300"
                     /protein_end="345"
                     /protein_start="329"
                     /score="11.8"
                     /tool="antismash"
                     /translation="MVEAHGTGTTLGDPIE"
     CDS_motif       complement(15499..15537)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0003"
                     /evalue="3.90E-01"
                     /label="PKSI-KS_m4"
                     /locus_tag="IE257_RS37300"
                     /protein_end="265"
                     /protein_start="252"
                     /score="4.7"
                     /tool="antismash"
                     /translation="FSDEADGIGWGEG"
     CDS_motif       complement(15679..15726)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0002"
                     /evalue="2.00E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE257_RS37300"
                     /protein_end="205"
                     /protein_start="189"
                     /score="19.7"
                     /tool="antismash"
                     /translation="GPAVTVDTACSSSLVA"
     CDS_motif       complement(15925..15951)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37300_0001"
                     /evalue="6.80E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="IE257_RS37300"
                     /protein_end="123"
                     /protein_start="114"
                     /score="6.5"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(16219..16293)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37300_PKS_Docking_Nterm.
                     1"
                     /evalue="3.80E-09"
                     /label="IE257_RS37300_PKS_Docking_Nterm.1"
                     /locus_tag="IE257_RS37300"
                     /protein_end="25"
                     /protein_start="0"
                     /score="27.9"
                     /tool="antismash"
                     /translation="LRTYLRRVTAELQQTRQQLQDSQDR"
     aSDomain        complement(16358..16549)
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37305_PKS_Docking_Cterm.
                     1"
                     /evalue="3.00E-14"
                     /label="IE257_RS37305_PKS_Docking_Cterm.1"
                     /locus_tag="IE257_RS37305"
                     /protein_end="737"
                     /protein_start="673"
                     /score="45.6"
                     /tool="antismash"
                     /translation="RELARIGQALDSVAPDPQAREDIVDHLRDLMAKLGSTERDATTDL
                     EAATDDEIFDFIDRDLGVS"
     CDS             complement(16358..>18570)
                     /NRPS_PKS="Domain: PKS_KR (296-477). E-value: 2.4e-52.
                     Score: 169.5. Matches aSDomain:
                     nrpspksdomains_IE257_RS37305_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (585-658). E-value: 1.5e-31. Score:
                     100.5. Matches aSDomain:
                     nrpspksdomains_IE257_RS37305_ACP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (673-737). E-value:
                     3e-14. Score: 45.6. Matches aSDomain:
                     nrpspksdomains_IE257_RS37305_PKS_Docking_Cterm.1"
                     /codon_start=2
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020243.5"
                     /locus_tag="IE257_RS37305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189974493.1"
                     /sec_met_domain="adh_short (E-value: 3.4e-57, bitscore:
                     181.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 9e-11, bitscore:
                     29.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.6e-17, bitscore:
                     52.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TAGNRVSLPTYAFQHQRYWLEGVTIGAQVVETTDVAESEFWDAVE
                     RQDLAGLTAVLDGAGGAGPDPAAGAEAWLPVLSAWRKGRREQSVLDSWRYRTEWRATGL
                     PSGTRLSGTWLLVTPGAGAPVEEVRDALVAAGAEVVVLEAEAGLDRAELAARLSVTPDV
                     AGVVSLLGWDEESGSERTVALVQAHVDSTVVVPLWVLTRGAAAVGSGDVVRPAQTQVWA
                     LGQIVGLEQPGVWGGLVDVPEVWDERVAAGFTGVLAAGEGEDQVAVRSSGAYARRLVRA
                     PLGGSPVPVRDWNPRGTVLVTGGTGGIGAHLARWLAKDGAEHLLLLSRRGEAAEGAAEL
                     AAELRGLGAEVSVVACDVTDRDALAAIIEAVPAEHPLTAVFHTAGVAGHGPVHELEATG
                     FAGQLSARTLGARHLDELTSERGVELDAFVLFSSGAAVWGSASNGANAAAGAFLDGLAR
                     ERRGRGLTATSVSWGGWQGTAMAQGGNAEQLLRRGVRLLDPAQATLALRQALEQDETSL
                     TVTDMDWERFTPGYTMARRRPLIEEIPEVAQVLGDTEDTAETPEDATAGADLKARLAGL
                     TDGEQHAQVLALVRGEAAQVLSHASTADITPNRPFQELGFDSLTAMDLRNRLNRATGLR
                     LPATLVFDHPNPQRLTSHLLAELAKGGEGNLSDVLDIRRELARIGQALDSVAPDPQARE
                     DIVDHLRDLMAKLGSTERDATTDLEAATDDEIFDFIDRDLGVS"
     gene            complement(16358..>18572)
                     /locus_tag="IE257_RS37305"
     aSDomain        complement(16595..16813)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37305_ACP.1"
                     /evalue="1.50E-31"
                     /label="IE257_RS37305_ACP.1"
                     /locus_tag="IE257_RS37305"
                     /protein_end="658"
                     /protein_start="585"
                     /score="100.5"
                     /tool="antismash"
                     /translation="LALVRGEAAQVLSHASTADITPNRPFQELGFDSLTAMDLRNRLNR
                     ATGLRLPATLVFDHPNPQRLTSHLLAEL"
     aSModule        complement(16595..17680)
                     /domains="nrpspksdomains_IE257_RS37305_PKS_KR.1"
                     /domains="nrpspksdomains_IE257_RS37305_ACP.1"
                     /incomplete
                     /locus_tags="IE257_RS37305"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(17138..17680)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS37305_PKS_KR.1"
                     /evalue="2.40E-52"
                     /label="IE257_RS37305_PKS_KR.1"
                     /locus_tag="IE257_RS37305"
                     /protein_end="477"
                     /protein_start="296"
                     /score="169.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="GTVLVTGGTGGIGAHLARWLAKDGAEHLLLLSRRGEAAEGAAELA
                     AELRGLGAEVSVVACDVTDRDALAAIIEAVPAEHPLTAVFHTAGVAGHGPVHELEATGF
                     AGQLSARTLGARHLDELTSERGVELDAFVLFSSGAAVWGSASNGANAAAGAFLDGLARE
                     RRGRGLTATSVSWGGWQG"
     CDS_motif       complement(17186..17296)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37305_0002"
                     /evalue="9.00E-12"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE257_RS37305"
                     /protein_end="461"
                     /protein_start="424"
                     /score="37.5"
                     /tool="antismash"
                     /translation="LDAFVLFSSGAAVWGSASNGANAAAGAFLDGLARERR"
     CDS_motif       complement(17579..17677)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS37305_0001"
                     /evalue="4.10E-15"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE257_RS37305"
                     /protein_end="330"
                     /protein_start="297"
                     /score="48.3"
                     /tool="antismash"
                     /translation="TVLVTGGTGGIGAHLARWLAKDGAEHLLLLSRR"
ORIGIN
        1 gcgaggtcgc ggccgcgtgt gtggcgggtg gcctgtccct ggaggacggt gcccgggtgg
       61 ccgcggtgcg ctcccgtctg gtcctggaga agctgtccgg caagggcggc atggtctccg
      121 tgtccctgcc ggtgaccgag gtcgaggagc ggatcgcttc gttcgacggc cggatcggtg
      181 tggctgccgt gaacgggccc gcctcggtgg tggtctcggg cgagcccgac gcactggatg
      241 agctgctggc ctcctgtgag gcggaaggtg ttcgggcgcg tcgtatcgcg gtggactacg
      301 cctcccactc cgcccaggtc gacgccctca acgaagacct cctgcgtgaa ctggccgaca
      361 tcagcccgcg gtcctcgtcc gtggccttcc actccacggt gagcggcgag cagatggaca
      421 ccgcgggcct ggacgcccgc tactggctgc gcaacatgcg cgagaccgtc gccttcgaag
      481 gagcggtgcg cgccgcgctc ggcgagggtc accggaccct gctggagatc agcccgcacc
      541 ccgtgctgac catggcggtc caggaggcca tcgacagcgc cggagtcacc gcccactcgt
      601 ccggttcgct gcggcgcgag gacggcggca ccggccgcct gctgaactcg ctcgccgagg
      661 cgtacgtcgc cggcgcgccc gtcgactgga ccaaggcgtt cgccggcgcc ggcgcccgcc
      721 gcgtggacct gcccacgtac gccttccagc ggcagcggta ctggctgcgc ctcgcggcct
      781 ccgggtccgg cgacgtgacg gccgcgggcc tcgggaaccc cgggcacccg ctgctcggcg
      841 cgtccgtcga gcccgcggag accgacggcc tcgtcctgac cggccgcatc tcgctgcggg
      901 accacccgtg gctggccgac caccgcgtca tgggtgcggt accgctgccg ggaacggcgt
      961 tcgtcgagct ggcggtggtc gcgggtgacc tcgtcgagtg cccggggatc gaggaactga
     1021 ccatggaggc cgcgctcctg ctccccgaga gcggcgccct cgacctccag ctcaccgtga
     1081 gcgcccccga cgggacgggc cggcgcgaga tcgggttctt cgcccggacg gacgacgaca
     1141 tcacggcggc cggctggacc cggcacggct cgggagtcct gtgcccggcc gcccccgtac
     1201 cggacgcgga gccggccgcc tggccgcctc cgggcgccga acccgtcgaa ctcgccggtc
     1261 tgtacgagca gtcgccggac agccccttcg cctacgggcc cgccttccac ggcctgcgcg
     1321 cggcctggtc gcgcggtcgg gaggtgttcg ccgaggtgca gctcccccag gagctgcacg
     1381 agcaggcgtc cgagtacctg ctgcaccccg cgctgctgga cgcggcgctg cacgcggtgg
     1441 gcttgggcga gctgctggac agcggcgggc agccgctgcg tccgttcgca tggaacgccg
     1501 tgtcgctgca cgccagcggt gcgaccacgc tgcgggtgac cctgtccccc gccggggcga
     1561 acgcggtgtc cctgcgcgcc gccgacggca ccggcgcacc ggtcgtcacg gtcggttcgc
     1621 tgatgctgag gccggtcgac gtcacggaac cggccgccgg acggtccgcc gtgcatccct
     1681 cgctcctgtc cctggcctgg acgccgctcc cgcttccggc ggcggacgcc gctccgtggg
     1741 ccgtgctcgg tgccgcgccg gccggccggc cgtcgtggac gggctcggac gtcccgcccc
     1801 agcagcacgc cgatgtcgcc gcgctggccg cgtcggtggc cggtggagga cccgtaccgc
     1861 agttcgccgt actcgacctg acggtcggtg agccctccgg ccccgagctc ctcacggcca
     1921 ccagggaccg cgcccagcgg gtcctggacg ccgcccgcgc ctgggtcgcg gaggacctcg
     1981 acgagcggct cgccccggtc acgctggtgg tggccacccg ggacgcggtg ggcacctcgg
     2041 cgcaggaccg gacggcaggg ctgggctccg ccccgctgtg gggtctggtg cgctccgtgc
     2101 agtcggagaa ccccggccgg ttcgtcctgc tggacaccga cggtctgccc gcgtcgtggc
     2161 aggccctgcc cgccgcgctc gcgacgggcg aagccgagat cgccctgcgc tccgggaccg
     2221 cgctggtccc ccggctcgac cggatgccgg cggccgaggc caccgacacg gaactgctgc
     2281 ccggcaccgc gctcgacgag ctcgacccgg cgggcaccgt gctggtgacc ggcgcgaccg
     2341 gcggcctcgg cagcctcgtc gccacccacc tcgccgaacg ccacggcgta cgcaacctcc
     2401 tgctgctcag ccgccggggc ccggaggccg agggcgccac cgagctcgtc cggcagctgg
     2461 agaagcacgg ggcgacggcg acgctggcgg cctgcgacgc ggcggaccgc gacgcgctgg
     2521 cggccgtact cgccgcgatc cccgccgagc agccgctgat cgcggtggtg cactgcgccg
     2581 gaaccgccga gaacgccctg ctggccacgc tcgacccggg catgatcgac cgcgtcttcc
     2641 gcgccaaggt ggatgccgcc gtccatctgc acgagctgac cgagggcatg gacctgtcgg
     2701 ccttcgtgct gttctcgtcc atagcgggca ccctcggcgg caccgggcag ggcaactacg
     2761 cggcggccaa caccttcctg gactccctcg cccggcaccg gcgggcccgc ggcctcgccg
     2821 ccacctcgct ggcctggggc ctgtgggcca ccgaacgcgg catgggaggc ggcctcaccg
     2881 aggccgcctc ggccggcacc ccgatgcgcg gagtgcgcgc cctgcccacc gaagagggcc
     2941 tggccctctt cgacctcggc tggcgctccg ccgaacccgt cctgttcccc gcccgcctgg
     3001 gcggcgccgc gctgcgcgcc caggcctccg ccgggacgct cccgccggtc ctgcgcggcc
     3061 tgttccgcac gtcgtcccgc cgcacggcgg gcaccgagac ccaggacgcg ggcacccagt
     3121 tgcgccgccg gctggcggag atgatgccgg tcgagcgcca ggagaccctg ctcgccctgg
     3181 tgcgcgggcg gatcgccgcg gtgctcgggc acgggtcccc ggaccagatc gaggccgacc
     3241 ggccgttccg cgacctcggc ttcacctcgc tgaccgccgt ggagctgcgc aaccggctga
     3301 acgcggcgac cggtctgcgc cttccggtga gcctcgtctt cgactacccg acgctggacg
     3361 cgctcgtacc gctgctgctg gggaagctgg tcccggacgg cggaccggcg gccgggcagg
     3421 agaaggacga cgaggaggcg gaggtccgcc gcgtgctggc ctgcatcccg ctgtctcgtc
     3481 tgcgcgagac gggtctgctg agctcgttgc tcgaactgac cggggaccgg ggcgagacga
     3541 agcaggaggc ctccgaccgc agtgacgaga tcaagtccat ggacgtggcg gcgctgctcg
     3601 cgatggccag gaccacgagc gccgcggacg acgcgtcacc ctccgcgcac gaagcgtaat
     3661 gggggcgatg taaggggcgg actttagggg ttggcggtcc atagcctgcc caaggcgcca
     3721 ccctcccccg tctctttgcc tttcccctcg cggtctttgc accgttccag cccgaaccca
     3781 caggaaaccg gagttccctt ccatgagcga atcgaccgcc gagcccatcc cgttcccctt
     3841 cccggacccg tccttcatcg gcgacctgcc tcccgagctg gcggagatcc gcgacggcga
     3901 ctccgtggtg gaggtgaagt tcccggacgg catgggcgcc tggctggtga ccaagcacgc
     3961 cgacatccgc aaggtcctcg tcgacccccg gttcagcagc aaggtcatgg ccgccgcggc
     4021 cgccgcgatg tcggagaccg agaccggcaa gctgatgaac gagtccctcg tcggcatgga
     4081 cgccccggag cacacccggc tgcgcaagct ggtctcccgt gccttcacag cccgccgcat
     4141 ggagctgatg cgcccgcgcg tcgcgcagct ggtcgccgag tacctcgacg agatggagac
     4201 ccagccgcag ccggtcgacc tggtcaagaa cttcgcgctg ccgctcccgg tgcgcgtgat
     4261 ctgtgaactc ctcggcgtac cggccgggga ccaggacacc ttccacgcct ggtcgaacgc
     4321 cctgctcggc gactggcagc aggtcgtcga gaaggaagcg gccacggtgt cgctggtgaa
     4381 ctacttcacc gagctggtca cggccaagcg cgagcagccc gccgacgacc tgatgagcga
     4441 cctgatccgc atcagcgagg acgacgagac gctcaccacg cgcgagatcg tcgccctgtc
     4501 catcggcatc ctcagcgccg gtcacgagac cactgccaac cagatcggca tgttcgtcct
     4561 gacgctgctc cacaacccgg acgagctggc gaagctgcgg gccaaccccg aggccgtccc
     4621 gcaggccgtg gaggagctgc tgcgcttcgt gccgctcacc acgaccggcg ggatcatccc
     4681 gcggctcacc accgccccgg tcgagctgag cgacggcagg acgcttccgg ccggcgtcgt
     4741 ggtgatgccc gccgtggcga ccggcaaccg cgaccccgag ctgttcgagg acggcgagcg
     4801 gctgaacctc tcccgccagc ccaacccgca cctcgcgttc ggcgccggca tccaccactg
     4861 cctgggtgcc cagctggccc gcatcgagct gcaggaggcg ctggccgccc tgctggcccg
     4921 cttcccggac ctcgcgctcg gcgtgccgga gtcggagctg cggctcaagc cggcctcgat
     4981 cgtccgcggc ctggagtcgc tgcccctcac ctggtagcac tccgctttcg tacggcgtcg
     5041 gcccccggga ccctgatgtg gtcccggggg ccgacgccgt cgtgtgcggg gtgggccgtg
     5101 accggtcggc cccgtgtccc gacgtgcccc gccggctccc acagccgggc ggggcactgc
     5161 tgttcgggga gtccggccgg gggcaggcgc gggcagcggg gagccgcgtc cgagaacggg
     5221 gcgcgcccgc agctacggga gccgccgtac ggggtggaac gggccgggac ggccgccgcg
     5281 cggccgggac ggccgacctc ctgacggacc gggaccggcc gtccgcgtcg gcggcgcccc
     5341 cgccggacgg gcgtgcgtac atgcgtgcgt acgtgcgtgc ctgcacggtg gcacgcgaag
     5401 gggccgcgct ccttacggaa cgcggcccct ggaaccaccg tgcgattaac gctgcttgag
     5461 cagccactcg tggatggcgg cggcggtcac gtcaccgttg ccctccagca tcgtgtagtg
     5521 gttgcccggc acgtcgatgg cgtcgtgctc cagcggccac acggcctgcc acttctccgg
     5581 cggcgggccg acctcgcccg gctcgacgcc gaagcactcc gaggcccgga cgagcagcgt
     5641 cggggtcttg atctccttcg gctgccagtg ctcgaacagg gcgaagtagg cggacatcgc
     5701 ggtgagacgg tttccggtca tccggccgaa gtccttctcc agctccagcg ccttgccctc
     5761 catcacggga acgatgtagg aggtctggtc gtagccggcc aggtagctgt cgatcaggac
     5821 cagcccctgc gggtagatcc cccgctcctc cagccgcgcg gtgacctcgt gggccacccg
     5881 gccgccggac gaacgcccgg tgaggacgaa cggagtgccc tccgtcagct cctcgatgcg
     5941 ccgtaccgcg tacgcggcgg cggcatcgac actgtccgcg accggctcac cggtcacgaa
     6001 gcccggcagc atcagcgacc acacgtcgcg gatgccgcgc agcggctcgg ccagcgccac
     6061 cagctcctgg ttgctggccc agaccgactg cgacgggaac ccgatgatct tcgggaaggc
     6121 atcgcccgca ccgagccgca cgagccccgg tcccttgcgc acgtcggccg ggtccgagaa
     6181 gttctcgcgc aggtcgaccg aattgcgcag cacgctgtgc ccgatgtcca ggcgcccgat
     6241 ctcgacggcc cgccggtaca tcgcttcgac accgttgatc acggcgatcc cgctggtgtc
     6301 cgcggcggcc tcggcctgct ccggctgctg cgccgccacg accggcgcgg ccgacgcggc
     6361 ggcgggtgcg acggagccct tgagctgctc gctcagttcg gcggcgaggg cggtcggcgt
     6421 ggggtggtcg aagaccacgg tggacgccag gcgcagtccg gtgagctcgt tgagccggtt
     6481 gcgcagctcc acggacgtca gcgagtcgaa gcccagctcg gcgaagccct ggccgtcctc
     6541 gatcgcctcc gccccggagt ggccgagtac ctgtgcgacc tcggcgcgga ccagttcggc
     6601 cagtacggcc acccggtcgg ccccggccgc tgcggccagc tgctcgtgca gccgggaggc
     6661 ggcccgtgtg tcggagcggg cggcccgccg ctgcggagcc ctcaccagcc cgcgcaggag
     6721 cgggggcacc tgctgttcgc cggtgggtcg ggcgaccgtg gtgttcaggc gcatcgggac
     6781 gagtacggcc tcgtcggcga cgcccagtgc ggcgtcgaag gccgccatgc ccgtctcggc
     6841 cgtgaaggcg gtgacgcctc cgcgggccat ccgggcgcgc tcggcccggc cgagctcggc
     6901 tcccatgccg ccgggctgct cccaccagcc ccacgcgagc gaggtaccgg ccagtccggc
     6961 ctcgtggcgg tggaccgcga gggcgtccag gaaggagttc gcggccgcgt agttgccctg
     7021 gccctggctg ccgagcatgc cggcggcgga ggagaagagc acgaacgccc gcagttccgc
     7081 gtcccgggtg agctcgtgca ggtgccaggc ggcatccgcc ttggcccgca ggacggtgtc
     7141 gatgcgctcc ggggtgagcg actcgatcgt gccgtcgtcg agcacacccg cggtgtggac
     7201 gactccggcc agcggctgcc cggccggtac gtcggccagc agggcctcca gtgcggtccg
     7261 gtccgccacg tcgcaggctg ccagccgcgc ttcggcgccc agttcgccca gttcggcgat
     7321 caggtccgcc gctcccggcg catccgcacc gctgcggctg gccagcacca ggtgccgtac
     7381 gccgtgttcg gtcaccaggt gccgcgcgac cacggcgccc agtgcgccgg tgccgcccgt
     7441 gatcaggacc gttccctcgg gcccgaagct gccggcgccc tcgggcgccg cggtgttcct
     7501 ggccagcctc ggtgcactcg cggcgccggc gcgcagcgcg agctgcggct caccggtgcc
     7561 gagtgccgcg ggcagtgccc ggtacgaggc ggcgtcgtcg tccaggtcga tcaggacgat
     7621 ccggtccggg tgttccgact gcgccgttcg cacgaggccc cagacggccg aggccccgat
     7681 gtccgtggtc cggtccgtgt cgagggccga gacggccccc cgggtcagca gcagcagctt
     7741 cgaagccgcg agccgctcgt cggacagcca gtgctggacg gtctccagga cgcggtgtgc
     7801 cgcgtggtgg gtggccgcga ggacacctcc ctggtcaccg ccgaagcagg tcatggccac
     7861 gacggccggc gcgggggcgc ccgactccac ggtgtccagg agggactgcg ggtcgaggta
     7921 cggcgtaccg gagagacccg cttcgaccag gcgcggccgg agcgacagcg ggtcgaagcc
     7981 gagcatcgcc cactcgcccg agatctgccg cgagcccagc ggcaccgggg cccaggtcag
     8041 ggtgaacagc gagtcctggc gcggcgcgga accggtaccg atgaactgct ccagtgcggg
     8101 gtcccgcatc gtcagcgagt cgacggtcgc gaccgggagg ccggaggtgt cggtcaccag
     8161 caccgacacc tcggaacgac cggccggtgc caggtggacc cgtacgaccg atgcgtgggt
     8221 ggcgtgcagc cgtactcccg tccaggcgaa gggcatgcct cccttgatcg gctcgcggcc
     8281 cggagcgagt ccgagaatgc cgagcgcgag cggttggagt gccgcgtcca gcagggccgg
     8341 gtgcaccccg tacccgctgc cctcggcgtc tgcctcctcg ggcagccgga cctcggcgaa
     8401 cagctcgccg tccttgtccc acagcgcccg caggccctgg aacaccggcc cgtaggcgaa
     8461 gccggcgtcg gccaggttgg gatagaagtc ctcgacgggg atctccgtcg ctccggccgg
     8521 gggccacacg gtcaccggct ccggggcggc ttcggccgcc gcaacgccgt cggccagcag
     8581 gccggaggcg tgccgggtcc actgcccgtc gtcgccgtca ccgtccgccc gggagtacag
     8641 gctgatcggg cgccggccgg attcgtcgag tccgccgacc aggatctgga tggcgcgtcc
     8701 cccctgctcg cccagcacca gcggtgcttc cagggtgagt tcgtcgatca gctcgcagcc
     8761 gacctggctg ccggcgcgca gcgcgagttc cacgaaggcg gtacccggca gcagggccgt
     8821 gcccagcatg gcgtggtggg cgatccaggg ctgggcggcc agcgagagcc gtccggtgaa
     8881 caggaacccg tcggactcgg gaagcgcgac cccggcgccg agcagcgggt gcccggtggc
     8941 ggtcaggccg atcgaggcgg gatccccggc ggaggtcgac atggagtcca gccagtagcg
     9001 cttgtgctgg aaggcgtacg tcggcaggcc gaccgtgcgg gcgccggtgc ctgcgaacag
     9061 ggccttccag tcgaccgggg taccggccac gtggatccgg cccagggcca gggccaggga
     9121 ggcggcctcg ggctgctcgc ggcgcagggc ggggacgcac gtggtgcggg tgcccgcgtg
     9181 gccgtggtgg tcgagggtct cctcggccat ggcggtcagc tccccgcccg ggcccagctc
     9241 caggaaggtg tcgacgcccc ggctcatcgc ggtcgcgacg ccgtcggcga agcggaccgt
     9301 gccgcggacg tgacggaccc agtagtccgg tgtggtcagc tcgtcgcccg cgatctcgcc
     9361 ggtcaggttc gagacgaccg ggatgcgcgg agcgcggaac tccgccgtgg ccaggacctc
     9421 gccgaacgcg gcgagcatcg gctccatccg ggccgagtgg aatgcatgac tgaccgtcag
     9481 ctccttggtg cgacggcctt gttcgcggaa gacgtcggca agggcgcgga ccggctcctc
     9541 gtcaccggag aggaccaccg aacgcgggcc gttgaccgcc gccacggaca ccccctccgg
     9601 cagttcgggg agttcgtcgg gcgcggcctg cacggccagc atcgctccgc cggacggcag
     9661 ggcctgcatg agccttccgc gggcggccac gatccggcac gcgtcgggca gggaccacac
     9721 gcctgccacg tacgccgcgg ccagctcacc gatggagtgg cccagcagga catcgggacg
     9781 tacgccccag gagctgacca gttcgtacag cgccacctcg aaggcgaaca gtcctgcctg
     9841 ggtgaacacg gtgcgcgaca gcgcggtgcc gtcggcgaac acgacgtcct tcaccggctg
     9901 gtccagcagg gtgtccagct gtgcgcacac ggcgtcgaag gcctcggcga agacggggtg
     9961 ggcgtcgtac agctcccggc ccatgccctg gcgctgcgcg ccctgaccgg tgaacaggaa
    10021 ggccgtcttg ccgtcgccgg cgacgccccg cggcgcaccg gccggggaac cgccctcggc
    10081 cagcgccgcc agacggttca ggagctcgtc ccggtccgcg ccgacgagca ccgcgcggtg
    10141 ttccagcgtc gctcgggtgg ccgccagcga gaagcccacg tccagcgggc ggacgtcctg
    10201 ctcgcgcagg tggtcggcga gccgccgggc ctggtcccgc aggccgtcct cggaacgggc
    10261 cgagatcacc cacggcacca ccggggcgac ttcctcggag cccgcggcat ccgccgtgga
    10321 ctcctgcgcc tcggtcccgg tttcctcggg tgcctgctcg aggatgatgt gcgcgttggt
    10381 gccgctgatg ccgaaggccg acacgccggc ccggcgcggg cggcccgtct gcggccactc
    10441 ccggttgccg gtcaggagct ccaccatgcc cgtggaccag tccacctcag gggtgggctc
    10501 gtccacgtgc agtgtcttgg gcagcacgct gtgcttcagc gccagcaccg acttgatgac
    10561 gcccgccacg ccggcggcgt actgggtgtg cccgatgttc gacttgacgg aaccgagcag
    10621 cagcggccgg tccgcggggc ggtcctggcc gtaggtggcc agcagggcct gtgcctcgat
    10681 cgggtcgccg agggccgtgc cggtgccgtg tgcctccagc atgtcgacat ccgccgtgtt
    10741 cagaccggcg gaagccagcg cctggcggat cacccgctgc tgcgaggggc cgttgggggc
    10801 ggtcaggccg ttggaagcgc cgtcggagtt cacggcggaa ccacgcagca ccgccagcac
    10861 cggacggccg tcgcgcacgg cgtccgagag gcgctggacg gccagcatgc cgacgccctc
    10921 gccccagccg gtgccgtccg cggccgccgc gaaggccttg gcccgcccgt cagcggcgag
    10981 gccgccctgc cgggagaact ccacgaacgc gccgggcgtg gccatcacgg tcacgcctcc
    11041 cgcgagtgcg aggtcgcact caccgttgcg cagtgcctgg gcagccaggt gcagcgtcac
    11101 cagcgaggac gagcaggcgg tgtccaccgt cacggcgggg ccttcgagac cgagtgcgta
    11161 ggcgacccgg cccgacatca cactgcccga ggcgccggtg agggcgtagc cgcccgcggc
    11221 ctcggtcgag ctcatcagta cggtcgtgta ctcctgcggc gtgcctccga cgaatacacc
    11281 ggtacggctg ccgcgcagcg cggacgggtc gtagccggcg cgttccagcg tctcccacga
    11341 gatctccagc agcagacgct gctgcgggtc catcgacagg gcctcgcggg gcgagatgtc
    11401 gaagaacgcc gcgtcgaagt cggcggcctc ggccaggaag gcaccctggc gcgccgagcc
    11461 cgactccgcg atgaagtcgt tcatggccag accctgccag ccacggtcgg ccgggaagtc
    11521 cgtcatctcg tcgcggttct cgacgaggag ctgccacagg tcctccggac cgcgcacccc
    11581 gccggggaac cggcaggcca tgccgacgat cacgatcggg tcgtcgtccg tcgcccgcag
    11641 ggccggcaga gcggcggtgg cggcgctgcc gtcgaagagc tgctcgtgca ggtggttggc
    11701 gatgcgctgc ggggtggggt agtcgaagac gatggtggcg gggaaacgca gtccggtggc
    11761 cgcgttgagc cggttgcgca gctccatggc ggtcagcgag tcgaagccga ggtcccggaa
    11821 gggccggtgg gccgtgatct cgtccgtcgt ctggtgcgtc agtacggccg cggcctcggt
    11881 gcgcaccagc tccagcaggc ggtcgtactg ttccggaacg gtgagaccga cgagggcctc
    11941 gcgcagtgcg gagccggagg actcgtcctc ggcggggacg acggagtcct cgctcagcac
    12001 acgggagacc tcggggatgt cctcgatgag cgggcgccgg cgggccatgg tgtagcccgg
    12061 ggtgaaacgc tcccagtcca tgtccgtgac ggtcagagcg gtctcgtcct gctcgatggc
    12121 ctgtcgcagt gcctcgatgg cgagggacgg ttccatctgg ccgacgccgc gccgcgacag
    12181 ctgctcggcg gtgccgtcga ccgccatgcc ggtgtcctgc cagccgcccc aggaaacgga
    12241 ggtggcggtg agaccgcggc tgcgccggtc ccaggccaga ccgtccaggt aggcgttggc
    12301 ggcggcgtac gcgccggtcc ccgcgctgcc ccagacggcg gcaccggagg agaacaggac
    12361 gaacgcgtcg aggggcaggt ccgcggtcag ggagtcgagg tgacgtgcgc cctggacctt
    12421 ggcggagaag atgccctcga agtgttcggg ggtggccagg gcgagttcgg cgtagccgga
    12481 tatgccggcg gtgtggaaga cggcggtgag ggggtgttcg gcgggaacgg cctcgatgat
    12541 cgcggcgagc gcgtcgcggt cggtgacgtc acacgccacg accgacacct cggcgcccag
    12601 gccacgcagt tccgccgcca gctcggcggc gccttcggcc gcctcaccac gacggctcag
    12661 cagcaggagg tgctccgcac cgtccttcgc caaccaacgc gccaaatggg caccgatacc
    12721 accggtacca cccgtgatca ggaccgtgcc ccgagggttc cagtcccgga cgggaaccgg
    12781 gctgccgccc agaggcgcac ggaccagacg acgggcgtac gcacccgacg accggaccgc
    12841 gacctggtcc tcaccctcgc ccgcggcaag aacacccgtg aacccggaag ccacccgctc
    12901 gtcccacacc tcgggaacgt cgaccagacc accccacgta cccggctgct ccagaccggc
    12961 cacctggccg agcgcccaca gctgcgtctg cacggggctg accggatcgg ccgagccgac
    13021 ggcggcggcg cccttggtca ggacccagag cctgcccgtc gcggcgacat cggccaggcc
    13081 ctgcagcagg gacagcgtcg ccgtcagagc agactcctcg tcccagccga ggagggacac
    13141 cacgcccgcc acgtccggag ttgcggagag ccgtgcggca agctccgcac ggtcgaggcc
    13201 ggcctcggcc tccaggacca cgacctcggc cccggccgcc acgagggcgt cccggacctc
    13261 ttcggcgggc gccccggtac cggacgtgac cagcagccac gtcccgtcca gacgaccgga
    13321 cgagggcacg gtcaccgaac gccacaccgt gcggtatcgc cacgagtcca ggacggaacg
    13381 ctcccgacgg cccttgcgcc acgccgacag cgccggaacc accggctccc acgcgtcgac
    13441 cgcgccaccg tccaccagct gcgccacgcc ttcgacatcc gcgcgctcga cggcgcccca
    13501 gaacgcagcg tcgaccgggt cgaccgcggc ttccgccacc ggtgccacga cgtccgcgat
    13561 ccagtagcgc tggtgctgga aggcgtaggt cggcagatcg acccgacgcg cctcggaccc
    13621 ggtgaacagc tgcttccagt cgaccggagc acccgccaca taggcctcgg ccagcgaggc
    13681 caggaagcgc tgggcgccac cgtcctcacg ccgcagcgaa ccgatggcag ccccggcgcc
    13741 cagcacgctc tcctgcgtct cctggatcgc catggtcagc acggggtgcg ggctcgactc
    13801 gacgaagacc ccgtattcct gttcggccag caggcgggtg accggttcga actgcacccg
    13861 ctcccgcagg ttccgcaccc agtacccggc atccagacca gccgtgtcca tccgctcacc
    13921 cgacaccgtc gaatagaacg ccaccgacga cgactgcggc cgaatctccg ccagctcacg
    13981 cagcagatcc tcattgagga catccacctg cgcggagtgg gaggcgtaat ccaccgcgat
    14041 acgacgcgcc cgaacaccct ccacctcaca cgaggccagc agctcatcca gggcatccgg
    14101 ctcgcccgag accaccaccg aggcgggccc gttcacggcg gcgacaccga tccggccgtc
    14161 gaagggagcg atccgctcct cgacctcggt caccggcagg gacacggaga ccatgccgcc
    14221 cttgccggac agcttctcca gcaccagacg cgaccgcacc gccgccaccc gggcaccgtc
    14281 ctccaacgac agaccgcccg ccacacacgc ggccgcgacc tcgccctggg agtgcccgat
    14341 caccgcggca ggctccacac cgaacgaacg ccacaccgcg gccagcgaca ccatcaccgc
    14401 ccacagcacc ggctggacca catccacccg gccccacagc ggatcatccg cctcacggaa
    14461 caccacatcc cggagcgacc agtccaccaa cggcgacagc gcacgctcac acgccaccat
    14521 cgactccgcg aacaccgcag acgaacccca caactcccgg cccataccga cccactgcga
    14581 accctgaccc gggaacacga acaccacacc actgccgacg tctccggtgc cccggacgag
    14641 cccggggagg tcgcggccct cggccagcgc ctccagccct tccgggagag tgccgcccgc
    14701 ctcggcgaac agcacggcgc gatgggcgag ctgcgaccgc gaactcagca gggagaaccc
    14761 cacgtcggcg atgtcgaggc cgtccttggg gtgcaggtat tcccggaggc gcgcggcctg
    14821 gtcacgcaga gcggcctcgg tattgcccga gatcagccac gggagcactg cgggcgacgt
    14881 ggacaggggc ggctcggccg cgtccgccgg ctgcgcttcc acgggctcgg cctcgggggc
    14941 ctgctcgagg acgacgtgcg cgttggtacc gctgatgccg aacgaggaca cgcccgcacg
    15001 gcgcgggcga cccgtctccg gccagtcccg ggtggtggtg aggagctcca cctcgccctc
    15061 ggtccagtcg atctgggtgc tcgggttctc ggcgtgcagg gtcttgggaa gtaccccgtg
    15121 ctggagggcg agcacgctct tgatgacacc ggcgacaccc gaaacggcct gggtgtgggc
    15181 gatgttggac ttgagggagc cgagccagag cgggcgtccg tcgtgccggt cctggccgta
    15241 ggtggccagc agggcctgcg cctcgatcgg gtcgcccagc gtcgtgcccg taccgtgcgc
    15301 ctccaccatg tccacgtcgg cgagggtcag gccggcgttg gccaccgcct gacggatcac
    15361 gcgctgttgc gaaggaccgt tcggggcgct cagaccgttc gaagcaccgt cctggttgac
    15421 tgccgaaccg cggatcaccg cgaggacggg gtggccgttg cgacgtgcgt ccgacagcct
    15481 ttcgagcagg acgaccgcgg cgccctcgcc ccagccgatg ccgtcggcct cgtcggagaa
    15541 ggccttgcag cggccgtcgg ccgccagacc gcgctgccgg gcgaaggtga cgaacgccga
    15601 ggaggtggcc atcaccgcga caccggcggc gagcgcgagg gaacagtccc cttggcgcag
    15661 cgactgggcc gcggagtgca gggcgaccag cgacgacgag caggccgtgt ccaccgtgac
    15721 ggcgggaccc tccagcccga gcacgtacga gacgcggccg gacatgatgc tcgccgaacc
    15781 gccggtgatc gcgtacccct ggtcggtcgg cgagttcatc agcttgacgg tgtgctcgat
    15841 ggccgtaccg ccgacgaaga caccggtgcg gctgccccgc agcgacaccg ggtcgatccc
    15901 ggcccgctcc agcgcctccc acgaggtctc cagcagcagc cgctgctggg ggtccatggt
    15961 cattgcctca cggggcgaga taccgaagaa ccccgcgtcg aagtcacccg caccgtgcag
    16021 gaacgcaccc tctcgggtgt aggtcgtccc cgggcggtcc gggtcgctgt cgaagagcga
    16081 agagaggtcc cagccgcggt cgtccgggaa tccccccacc gcgtcgacgc cgttgacgac
    16141 catgtgccac agctgctccg gcgaatcgac gccgccgggc agccggcagg ccatgccgac
    16201 gacggccaac ggctcgcggg cgcgatcctg gctgtcctgg agctgctgac gagtctgctg
    16261 tagctcagcc gtgactcggc gcaaataggt acggagtttg tcctcggtca tcgtgaaacc
    16321 ccactctgaa gcaattgaag gcccggcagc tgtgtgttca ggacacgccc aggtcgcggt
    16381 cgatgaagtc gaagatctcg tcgtccgtgg cggcttcgag atctgtggtg gcgtccctct
    16441 cggtggagcc gagcttggcc atgaggtctc gcaggtgatc gacgatgtcc tcacgggcct
    16501 gggggtccgg tgcgacgctg tccagcgcct gtccgatcct ggccagctcc cgcctgatgt
    16561 ccaggacatc ggagaggttg ccctctcccc ccttggcgag ttcggccagg aggtggctgg
    16621 tgagccgctg cgggttcggg tggtcgaaga cgagggtggc gggcagccgc aggccggtgg
    16681 cccggttcag tcggttgcgc aggtccatcg ccgtcagcga gtcgaacccc agctcttgga
    16741 agggccggtt cggagtgatg tcggcggtcg aggcgtgaga cagcacctgg gccgcctcac
    16801 cacgcaccag cgccagtacc tgtgcgtgct gttcgccgtc ggtcaggccg gccaggcggg
    16861 ccttcaggtc ggcgccggcg gtggcgtcct cgggcgtctc cgccgtgtcc tcggtgtcgc
    16921 ccaggacttg ggcgacttcg gggatctcct cgatgagcgg gcgtcggcgg gccatggtgt
    16981 agcccggggt gaaacgctcc cagtccatgt ccgtgacggt cagcgaggtc tcgtcctgct
    17041 ccagcgcctg acgcagggcc agggtcgcct gcgcggggtc gagcagccgc acgccacggc
    17101 gcagcagctg ctcggcgttg ccgccctgag ccatcgcggt gccctgccag ccgccccagg
    17161 agacggaggt cgcggtcaga ccgcggcccc ggcgctcgcg ggccagaccg tccaggaacg
    17221 cacccgcggc ggcattggcg ccgttgctcg cgctgcccca gaccgctgca ccggaggaga
    17281 acagcacgaa cgcgtccagc tcgacgcccc gttcggacgt gagctcgtcc aggtgccgcg
    17341 caccgagcgt cctcgccgac agctggccgg cgaaaccggt cgcttcgagt tcgtgcaccg
    17401 ggccgtgtcc ggcgacgccg gcggtgtgga agacggcggt gagggggtgt tcggcgggaa
    17461 cggcctcgat gatcgcggcg agcgcgtcgc ggtcggtgac gtcacacgcc acgaccgaca
    17521 cctcggcgcc caggccacgc agttccgccg ccagctcggc ggcgccttcg gccgcctcac
    17581 cacgacggct cagcagcagg aggtgctccg caccgtcctt cgccaaccaa cgggccagat
    17641 gggcaccgat gccaccggta ccacccgtga ccaggaccgt gccccgaggg ttccagtccc
    17701 ggacgggaac cgggctgccg cccagggggg cacggaccag acggcgggcg tacgcacccg
    17761 acgaccggac cgcgacctgg tcctcaccct cgcccgcggc aagaacaccc gtgaacccgg
    17821 cggccacccg ctcgtcccac acctcgggaa cgtcgaccag accaccccag acaccgggct
    17881 gctccagacc cacgatctga cccagcgccc acacctgcgt ctgcgccggc cggaccacgt
    17941 cgcccgaacc caccgccgcg gcaccccgcg tcagcaccca caggggcacc accacagtgc
    18001 tgtccacatg cgcctgtacg agggccacgg tccgctcgga gccggactcc tcgtcccagc
    18061 cgaggaggga caccacgccc gccacgtccg gagttacgga gagccgtgcg gcaagctccg
    18121 cacggtcgag gccggcctcg gcctccagga ccacgacctc ggccccggcc gccacgaggg
    18181 cgtcccggac ctcctccacc ggtgccccgg cacccggcgt caccagcagc cacgtccccg
    18241 acaggcgggt tcccgagggg agacccgtcg cgcgccactc ggtgcggtaa cgccacgagt
    18301 ccagcaccga ctgctcccga cggcccttgc gccaggcgga cagaaccggc agccaggctt
    18361 cggcacccgc ggccgggtcc gggccggcgc ctcccgcgcc gtcgaggaca gccgtgaggc
    18421 cggccaggtc ctggcgttcg acggcgtccc agaactcgga ttcggcaacg tcggtcgttt
    18481 ccaccacctg ggcgccgatg gtcacaccct ccagccagta gcgctggtgc tggaaggcgt
    18541 aggtcggaag ggacacccgg ttgcccgcgg tg
//
