LOCUS       NZ_BMVL01000021        25179 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence21, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000021
VERSION     NZ_BMVL01000021.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 107518)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 82339
            Orig. end                         :: 107518
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25179
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..25179
                     /SMILES="NC([*])C(=O)NCC(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25179
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:25169](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..25169)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(385..1215)
                     /locus_tag="IE257_RS35460"
                     /old_locus_tag="GCM10010343_72530"
     CDS             complement(385..1215)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951370.1"
                     /locus_tag="IE257_RS35460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72530"
                     /product="FkbM family methyltransferase"
                     /protein_id="WP_189973960.1"
                     /transl_table=11
                     /translation="MATNRVSATGRLPRPPYPSEPVRPAPARAGVRVSAVAGGLSWASS
                     RFSFVEDEVAGLRPFVRPGAVCLDIGAEYGLYTWALSALSGPEGSVHSIEPLPGPAAWL
                     RTAASAFGCDNVTVHRVALAARAQPGTMSLPRRRLLPVHGRAYLTEGANGPGPNTEFAR
                     SRSVATAVRTVDGLCHHLGLDRVDFIKADVEGAEAAVLAGARRTLLRHRPSLLLEIEDR
                     HLAKYDARPAGLVAGLRGLGYSMYRWREGGWHPEAAVTDDFRNYLFTTRPPTHD"
     misc_feature    complement(1180..1182)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    1588..1599
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            complement(1895..2836)
                     /locus_tag="IE257_RS35465"
                     /old_locus_tag="GCM10010343_72540"
     CDS             complement(1895..2836)
                     /codon_start=1
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146498.1"
                     /locus_tag="IE257_RS35465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72540"
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="WP_229920853.1"
                     /transl_table=11
                     /translation="MTVPIGLILSGDSPRSQGKDADHAARLAELDAPLPPILVDRRTMR
                     VIDGTHRLMAATLKGQESIDVEFFDGTAEEAFLRAVEANVAHGLPLPHADRRRAAERII
                     RSHPRSSDRAIARSAGLGARTVAKIRREMTGPGQQPVARVGLDGKVRPLNSAEGRRRAA
                     EIITEDPMTSLREVARRAGISPATVSDVRKRLASGQPPAAAEATGMSGAARADRPRTVR
                     GMPPVPSPPAAVVERLLRDPSLRHKQEGRQLLRLLQQNAIGTREWSELTTVVPSHCGAL
                     VVDLARQVAETWMEFARELDEGAQPEGHRAAC"
     misc_feature    3141..3157
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.94"
                     /tool="antismash"
     misc_feature    complement(3141..3157)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 21.91"
                     /tool="antismash"
     gene            complement(3187..4254)
                     /locus_tag="IE257_RS35470"
                     /old_locus_tag="GCM10010343_72550"
     CDS             complement(3187..4254)
                     /codon_start=1
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238102.1"
                     /locus_tag="IE257_RS35470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72550"
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="WP_229920854.1"
                     /transl_table=11
                     /translation="MGPGSATDSGRTAAGADARGREIVSLPIALLVPGESPRLDGQDAE
                     HVTRLAELDVPLPPILVDRRTMRVIDGMHRLLAACLRGQESIDAELFEGTPEEAFLRAV
                     EANVTHGLPLSQKDRRAAATRIIEAHPQMSDRAIARASGLGAKSVAAIRRASAGEAGQL
                     AVRIGQDGRVRPLSSAEGRRKAAELIAENPEASLREVARRAGISPATVSDVRRRLLAGQ
                     QPVAERRPVALAPDVDGTLPSIPRQMSRARPVRKARPVQLDPVQLMEKLVRDPSLRHKE
                     GGRQLLRLLQQGALGDRAWAQLAAVVPSHARDSVVGLARQYAETWMEFAQELDENMRPV
                     GAEAGLPRQRFGMRA"
     misc_feature    complement(4084..4086)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4165..4167)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4439..4457
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 25.71"
                     /tool="antismash"
     misc_feature    4470..4484
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.73"
                     /tool="antismash"
     misc_feature    complement(4603..4620)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.94"
                     /tool="antismash"
     misc_feature    4734..4748
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(4757..4771)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(4782..4997)
                     /locus_tag="IE257_RS35475"
                     /old_locus_tag="GCM10010343_72560"
     CDS             complement(4782..4997)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1009: mbtH-like protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004923629.1"
                     /locus_tag="IE257_RS35475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72560"
                     /product="MbtH family protein"
                     /protein_id="WP_308279507.1"
                     /transl_table=11
                     /translation="MTNPFEDPDAEYLVLVNDEGQHSLWPVFVDVPEGWESVFGKAGRQ
                     ECLDHIEKSWTDMRPKSLIEAMAAQK"
     gene            5471..6268
                     /locus_tag="IE257_RS35480"
                     /old_locus_tag="GCM10010343_72580"
     CDS             5471..6268
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-251). E-value:
                     1.3e-21. Score: 69.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS35480_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006351006.1"
                     /locus_tag="IE257_RS35480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72580"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_189973962.1"
                     /sec_met_domain="PF00561 (E-value: 1e-16, bitscore: 53.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-21, bitscore:
                     70.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFVSTNGIRLSYQRSGRGEPVLLIMGSGAAGRVWTMHQTPALHR
                     AGYETIVFDNRGIAPSSTPPGDYSLADMTADTIGLIEALDIGPCRIVGTSMGAMIAQEL
                     ALARPELVRCAVLMATRARSDAARRMMREADRELRASGITLPPKYEAVRTVLEMLSPTT
                     LNDEAAASGWLEIFELTSGSSAPGQDSVDTFGDRREALRELTVPCRAIAFSDDLICPPH
                     LVAEVADAIPDCDYVEIPGCGHLGNLENPDEVNTAVIEFLGKY"
     aSDomain        5531..6223
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35480_Abhydrolase_1.1"
                     /evalue="1.30E-21"
                     /label="IE257_RS35480_Abhydrolase_1.1"
                     /locus_tag="IE257_RS35480"
                     /protein_end="251"
                     /protein_start="20"
                     /score="69.3"
                     /tool="antismash"
                     /translation="PVLLIMGSGAAGRVWTMHQTPALHRAGYETIVFDNRGIAPSSTPP
                     GDYSLADMTADTIGLIEALDIGPCRIVGTSMGAMIAQELALARPELVRCAVLMATRARS
                     DAARRMMREADRELRASGITLPPKYEAVRTVLEMLSPTTLNDEAAASGWLEIFELTSGS
                     SAPGQDSVDTFGDRREALRELTVPCRAIAFSDDLICPPHLVAEVADAIPDCDYVEIPGC
                     GHLGNLENP"
     CDS_motif       5729..5785
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35480_0001"
                     /evalue="2.10E-05"
                     /label="NRPS-te1"
                     /locus_tag="IE257_RS35480"
                     /protein_end="105"
                     /protein_start="86"
                     /score="17.1"
                     /tool="antismash"
                     /translation="GPCRIVGTSMGAMIAQELA"
     gene            6298..8232
                     /locus_tag="IE257_RS35485"
                     /old_locus_tag="GCM10010343_72590"
     CDS             6298..8232
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019549248.1"
                     /locus_tag="IE257_RS35485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72590"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189973963.1"
                     /transl_table=11
                     /translation="MARKKSAAEDKARLRFDDGSITRRRIKQGTFRRILPYALTYPWPM
                     TLLVISTVVDAAATAAGPLLLKMVIDDGILPGRTDTVIWLCLGVTGLALVEGAAMYVQA
                     WASGRIGEGVVYDLRNRVFTHIQKQSLTFFTRAQTGALVSRLNTDVVGARQAVTVLLSQ
                     TLSVLLSLALVLAAMFYLSWQITLAALAMIPLFLLPARLVSGRLQRLTRERMELDGDMS
                     SLMSERFNVSGAMLAKLYGRVEDESGLFARKAGRVRDIAVLGILYGRTLSIVGTVLTAI
                     TTALVYGLGGVLTIDGTLALGTLVAMVALLMRLYGPINQLSSMQATVMTALVSFDRVFE
                     VLDLEPNIAERPGARDLADARPAAGSGEAPDITFEGVSFRYPSGDEAALASLGPAGGDR
                     PGGADEAWTLQNLDFHAPAGKLTALVGPSGAGKTTITQLVPRLYDPDRGTVRIAGQDVR
                     DLTLQSLRDTIGVVTQDAHLFHDTLRANLEYARPGASEQELIDACEAALIWDTVRALPD
                     GLDTLVGDRGYRLSGGEKQRIALARLLLKAPSVVVLDEATAHLDSDSEAAIQRALKTAL
                     AGRTSLVIAHRLSTIREADRILVVEAGQIREQGTHKELLAADGLYAALYRTQFAQDEPL
                     EEAAVLDPA"
     assembly_gap    8272..8307
                     /estimated_length=36
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(8484..9956)
                     /locus_tag="IE257_RS35490"
                     /old_locus_tag="GCM10010343_72600"
     CDS             complement(8484..9956)
                     /NRPS_PKS="Domain: AMP-binding (51-456). E-value: 1.5e-85.
                     Score: 279.2. Matches aSDomain:
                     nrpspksdomains_IE257_RS35490_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="IE257_RS35490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72600"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_189973964.1"
                     /sec_met_domain="AMP-binding (E-value: 5.7e-92, bitscore:
                     300.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIVDGLLGPTELPELAISPGEIRHARALAVTRDHPVDLTDAVIT
                     RVERFALDGDRPAVRDAHRRLGYAELAVEARRLATLMEREGVTPGTVVAVGGERGSTVV
                     AAFLATELLGALYLPADGNWPARRVADVIGQAGAVMLLDTDREAVSASLAEGAREAGVR
                     VVRAADAASCEPCRGPARLESPDQPRYVLFTSGSTGRPKGAVVEHQGMLNHLFAKVVDL
                     GLTERDVVAQTAPLGFDISIWQMLCPLVVGGEVAVVDDATAHDSVAFARLIGEQGVSVV
                     ELVPTMVRLLLDDLAAAPAAGRLEGLRWMLATGEELPTEVARRWLQEMPQAGLVNAYGP
                     TECSDDVTHHTVLPADLGLLRLPIGTPVVNCQLYVLRREDDGWHACAPGETGELFVGGV
                     CVGRGYVHDHDRTRDAFFRDPFADTPTGRLYRTGDAVTVLPQGALQYLGRVDRQVKIAG
                     VRMELGEIEAVLQRHPAVGAAAVVVHDFARRR"
     CDS_motif       complement(8556..8621)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35490_0003"
                     /evalue="4.90E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IE257_RS35490"
                     /protein_end="467"
                     /protein_start="445"
                     /score="31.5"
                     /tool="antismash"
                     /translation="YLGRVDRQVKIAGVRMELGEIE"
     aSDomain        complement(8589..9803)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35490_AMP-binding.1"
                     /evalue="1.50E-85"
                     /label="IE257_RS35490_AMP-binding.1"
                     /locus_tag="IE257_RS35490"
                     /protein_end="456"
                     /protein_start="51"
                     /score="279.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LDGDRPAVRDAHRRLGYAELAVEARRLATLMEREGVTPGTVVAVG
                     GERGSTVVAAFLATELLGALYLPADGNWPARRVADVIGQAGAVMLLDTDREAVSASLAE
                     GAREAGVRVVRAADAASCEPCRGPARLESPDQPRYVLFTSGSTGRPKGAVVEHQGMLNH
                     LFAKVVDLGLTERDVVAQTAPLGFDISIWQMLCPLVVGGEVAVVDDATAHDSVAFARLI
                     GEQGVSVVELVPTMVRLLLDDLAAAPAAGRLEGLRWMLATGEELPTEVARRWLQEMPQA
                     GLVNAYGPTECSDDVTHHTVLPADLGLLRLPIGTPVVNCQLYVLRREDDGWHACAPGET
                     GELFVGGVCVGRGYVHDHDRTRDAFFRDPFADTPTGRLYRTGDAVTVLPQGALQYLGRV
                     DRQVKI"
     CDS_motif       complement(8709..8795)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35490_0002"
                     /evalue="1.00E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="IE257_RS35490"
                     /protein_end="416"
                     /protein_start="387"
                     /score="33.9"
                     /tool="antismash"
                     /translation="PGETGELFVGGVCVGRGYVHDHDRTRDAF"
     CDS_motif       complement(9333..9389)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35490_0001"
                     /evalue="1.40E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IE257_RS35490"
                     /protein_end="208"
                     /protein_start="189"
                     /score="29.9"
                     /tool="antismash"
                     /translation="YVLFTSGSTGRPKGAVVEH"
     gene            10230..11213
                     /gene="sbnA"
                     /locus_tag="IE257_RS35495"
                     /old_locus_tag="GCM10010343_72610"
     CDS             10230..11213
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="sbnA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948371.1"
                     /locus_tag="IE257_RS35495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72610"
                     /product="2,3-diaminopropionate biosynthesis protein SbnA"
                     /protein_id="WP_189973965.1"
                     /sec_met_domain="PALP (E-value: 2.4e-52, bitscore: 170.7,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIISSPHEFNVEDLYIDLRRLNGTPLYLKCEGFNFAGSIKLKAA
                     AEMLDAAELEGLIRPGSVLVESSSGNLGVALAIIAADRGYRFVCVTDPRCNPTTVRLMR
                     SLGADVRVISKQDANLGYLHSRIQYVRDLCASDDRYVWLNQYANPNNWRAHYEQTAPEI
                     ERSFPDLEVLFVGAGTTGTLMGCARYFKERRRPVTIVAVDAVGSVTFGGVPERRVVPGL
                     GTSTRPALLDEAWVDDVVHVLETDTIRACHSLAARGFVLGGSTGTVVSGATRWLGEKYP
                     GEDPVAVAISPDLGERYLTSVYDETWLRTHFGQADLFTDTDWSPYP"
     misc_feature    10284..10286
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11210..12235
                     /gene="sbnB"
                     /locus_tag="IE257_RS35500"
                     /old_locus_tag="GCM10010343_72620"
     CDS             11210..12235
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sbnB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482025.1"
                     /locus_tag="IE257_RS35500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72620"
                     /product="2,3-diaminopropionate biosynthesis protein SbnB"
                     /protein_id="WP_189973966.1"
                     /transl_table=11
                     /translation="MTQPPSFSVISGAQVADVLTGHEKQVTAMVEQAYRLHGEGLTVNP
                     DSYFLRFPERPSSRIIALPASVGGDVDVHGIKWISSFPENVAAGIPRASAVVVLNDTTT
                     GYPLACLESSVISASRTAASAALAAVTLADRRGVTPRRVGFIGVGLIARYLHTYLVANG
                     LSFDEVGVFDLDRGHAEGFEGYLTRSGEGRVTIHESAESLIAGSDLIVLATVAGEPHIL
                     DPELFSHNPLVLHVSLRDLSPEIILSSYNLVDDVDHCLKANTSPHLAEQRTGNRDFVDG
                     TLYDLLEGRTTPPADRPVVFSPFGLGVLDLAVAKYVYDEVDAAGALLTVPDFFHEMKRY
                     G"
     gene            complement(12317..13759)
                     /locus_tag="IE257_RS39565"
     CDS             complement(12317..13759)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (122-468). E-value:
                     3.8e-34. Score: 110.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS39565_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838206.1"
                     /locus_tag="IE257_RS39565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_229920857.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.8e-34, bitscore:
                     110.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTGTAALADAGPDLLRLPGLPDTPPATPRRPTRTRRPGGGGDE
                     RPTGDLRRDDLHGSVSDPVLDTMNFLNEITHRYPGAISFAPGRPYAGFFETEQIFTHLR
                     RYLDHLAEGGASPDEIRSALFQYGPTAGQIRELIADSLRADEGTDVPAESVVVTVGAQE
                     AMLLAVRALIAGPEDVLLVSSPCYVGITGAARLFDIVPTAVEETAGGFRCADLEAAILA
                     ERARGRRPRAFYVVPDHSNPSGTTMPLEQRKELLDLAARHGILILEDSPYRAVSPGRQL
                     PTLKSLDRGRHVVHLGSLSKTLFPGARVGYVVADQVVVGADGSTGLLADELTRIKSMVT
                     VNTSPLSQAVVAGMLLAAGGRTSEFNAGTAAYYGDAMRATLRELDRCFPPKEREALGIR
                     WNEPSGGFFLAVDVPFVADNAALEACAEEYGVIWTPMSYFYPQGGGERSLRLSVSYLTH
                     SSIAEGVERLADFIRSRADGRP"
     aSDomain        complement(12356..13393)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS39565_Aminotran_1_2.1"
                     /evalue="3.80E-34"
                     /label="IE257_RS39565_Aminotran_1_2.1"
                     /locus_tag="IE257_RS39565"
                     /protein_end="468"
                     /protein_start="122"
                     /score="110.3"
                     /tool="antismash"
                     /translation="ALFQYGPTAGQIRELIADSLRADEGTDVPAESVVVTVGAQEAMLL
                     AVRALIAGPEDVLLVSSPCYVGITGAARLFDIVPTAVEETAGGFRCADLEAAILAERAR
                     GRRPRAFYVVPDHSNPSGTTMPLEQRKELLDLAARHGILILEDSPYRAVSPGRQLPTLK
                     SLDRGRHVVHLGSLSKTLFPGARVGYVVADQVVVGADGSTGLLADELTRIKSMVTVNTS
                     PLSQAVVAGMLLAAGGRTSEFNAGTAAYYGDAMRATLRELDRCFPPKEREALGIRWNEP
                     SGGFFLAVDVPFVADNAALEACAEEYGVIWTPMSYFYPQGGGERSLRLSVSYLTHSSIA
                     EGVERL"
     misc_feature    complement(13753..13763)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(<13766..14752)
                     /locus_tag="IE257_RS39570"
                     /pseudo=""
     CDS             complement(<13766..14752)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013253.5"
                     /locus_tag="IE257_RS39570"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="alpha-hydroxy acid oxidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGAAGPLTSADYEALARRRLEPAVWDFIAGGAGDERTLAANPAVF
                     DQVRLRPRVLTGMGAPATGTEILGRTWPVPLGVAPMAYHTLAHPDGEVATARGAGRAGA
                     LVVSSFASRTFADIAAAASGPLWLQVYCFRDRDTTRGLVEHAERAGFEALVLTVDAPHL
                     GRRLRDLRNDFRLPTGVVPANLVGGGFSSPSGHARTEFDPSLDWSVVDWLRSISSLPVL
                     VKGILTASDARSALAAGVDGILVSNHGGRQLDRAPATLEVLPEIAHAVAGAVPLLLDGG
                     VRRGTDVLAALALGADAVLLGRPVLHGLAVSGEHGVQHVLGLVAEELA"
     gene            complement(14752..15771)
                     /gene="hppD"
                     /locus_tag="IE257_RS35510"
                     /old_locus_tag="GCM10010343_72640"
     CDS             complement(14752..15771)
                     /EC_number="1.13.11.27"
                     /GO_function="GO:0003868 - 4-hydroxyphenylpyruvate
                     dioxygenase activity [Evidence IEA]"
                     /GO_process="GO:0006559 - L-phenylalanine catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006572 - tyrosine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hppD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337595.1"
                     /locus_tag="IE257_RS35510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72640"
                     /product="4-hydroxyphenylpyruvate dioxygenase"
                     /protein_id="WP_189973968.1"
                     /transl_table=11
                     /translation="MAVQDISYVELFASDKVAAVDYFVSALGFTRVADSVEVDRSSILL
                     QQGDVRLVVTSGRGIWKFLDSHGDGIADIAMTCDDPAAAEAKAVAAGAVPLASPRGNVV
                     VAGFGSVTHTLLPAPARPGGPLADGRRWTPSPEITSTEPSRIRLLDHIAVCLAGGTLEE
                     YADFYRDAFGFSRYSSEYVAVGGQAMDSIVVRSASGRVTFTLVAPDPGKEPGQLDAFLE
                     RNGGPGAQHLAFLVDDIIPSVGEARDRGVEFLNTPDTYYDMLAERFEGMAEQIAELRKA
                     QVLADRDEWGHLLQLFTRSPYERNTLFFELIQRQGSRGFGSANIRALYEAVERDRLSS"
     misc_feature    15731..15749
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.78"
                     /tool="antismash"
     misc_feature    complement(15742..15756)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(15933..17516)
                     /locus_tag="IE257_RS35515"
                     /old_locus_tag="GCM10010343_72650"
     CDS             complement(15933..17516)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006351005.1"
                     /locus_tag="IE257_RS35515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72650"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_189973969.1"
                     /transl_table=11
                     /translation="MSDELLYLKSKVIIEPLVDRFFAWPYTVAPVQAAMNLAFLQLPLL
                     ESYLQSPQVHVAASNNPELRGGYFINIPEERADEVRELVESIKKERAPMLRFAEAIAAG
                     QEILRANATGFDLTPLYPKMPAELGGLIELAYDTDNQAQMRFMEPVVYKSEVYDQGRQS
                     VQLSFETGIERPFILSTPRLPSPDVLELDIPFNHPGLTELFKARVQGTTLAHLSEALEL
                     DEAQTAHLATMLSDTPSGAADRHIEAGGRIRYFGHACLVLQTPEAAIVTDPFISADSTA
                     GDRYTLDDLPDYIDLVLITHGHQDHIVLETLLQLRGRLGAIVVPRSSRGNLADPSMAHM
                     LRNQGFNVIEVDDFDEVEFPGGKITATPFLGEHCDLDIRAKSTYWAELAGKKVFIGADS
                     SGIEPALYRYIKSHLGTADIAFLGMECDGAPLTWLYQALLTIPVTKKMSNSRKLSGSNA
                     EQAAAIMTELGATEAYVYAMGEEDWLGHVMATTYTEDTYQIKQIEEFLTWCKDRDITAG
                     HLFKQQEWVW"
     gene            complement(17908..18396)
                     /locus_tag="IE257_RS35520"
                     /old_locus_tag="GCM10010343_72660"
     CDS             complement(17908..18396)
                     /GO_function="GO:0002161 - aminoacyl-tRNA editing activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092593.1"
                     /locus_tag="IE257_RS35520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72660"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_189973970.1"
                     /transl_table=11
                     /translation="MPEDRDAFQHLIDLLASGDASYRTIPHEPEGRTEEASELRRHPLE
                     QAAKSIVIRVATGKRSRRYVLAVVPGDRRVDLPALALRYGGREASFATQEVAERLAGSV
                     SGSITPFAFSTELDLLVDEGLLVHDEIYFNAGRLDLSVALSVADYQRLARPAVAAIAV"
     gene            complement(18661..19521)
                     /locus_tag="IE257_RS35525"
                     /old_locus_tag="GCM10010343_72670"
     CDS             complement(18661..19521)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="IE257_RS35525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_72670"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189973971.1"
                     /transl_table=11
                     /translation="MIEIRELTKRYGNVTAVDGLSFTVGAGRVTGLLGPSGAGKSTTLR
                     LLLGLSAPTSGSASIGGREFRDRPPGAREVGVLLGTSGVYCPHGGNTAREYLTGVARRH
                     GIPLGRLDDVLDIAGLTSAEHRRVATFSLGMRQRLGIACALLADPPVLVLDEPLNGLDQ
                     RGLRWARTLFHRLAAEGRTVLVSGQLPMELADMADELVIIARGELVAGQRAARLAVRGR
                     RLPVSVRTPDVAVLSSLLADEGAAVELNEDQSLTVTGLSARRIGDVAFLNVVPLHELAP
                     EIPER"
     misc_feature    complement(18850..18852)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19516..19531)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    19720..19734
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.5"
                     /tool="antismash"
     gene            complement(20001..25169)
                     /locus_tag="IE257_RS35530"
     CDS             complement(20001..25169)
                     /NRPS_PKS="Domain: AMP-binding (7-217). E-value: 5.2e-49.
                     Score: 158.8. Matches aSDomain:
                     nrpspksdomains_IE257_RS35530_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (329-395). E-value: 4.3e-26. Score:
                     82.9. Matches aSDomain: nrpspksdomains_IE257_RS35530_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (411-713). E-value:
                     9.1e-111. Score: 361.6. Matches aSDomain:
                     nrpspksdomains_IE257_RS35530_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (894-1290). E-value:
                     4.3e-110. Score: 360.0. Matches aSDomain:
                     nrpspksdomains_IE257_RS35530_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1403-1467). E-value: 9.6e-24.
                     Score: 75.4. Matches aSDomain:
                     nrpspksdomains_IE257_RS35530_PCP.2"
                     /NRPS_PKS="Domain: Thioesterase (1489-1711). E-value:
                     7.1e-42. Score: 136.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS35530_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE257_RS35530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_308433300.1"
                     /sec_met_domain="PP-binding (E-value: 6.9e-15, bitscore:
                     48.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 7.6e-63, bitscore:
                     204.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.5e-115, bitscore:
                     376.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 2e-37, bitscore:
                     122.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQAQATDLGNTVVFASLTTGGELHVLEEGAVTDPVAVSSYLVEH
                     GIDFLKAVPSHLAALASVTGVEGVLPGRSLVLGGEAAAPALVRELVEHGGDGVVFNHYG
                     PTETTIGVATTRLEVSDADAGLVPVGAPVANTRFYVLDASLRPVPVGVVGELYVAGVQL
                     ARGYVKRTALTAERFVANPFEPGLRMYRTGDRACWTEDGRVVFQGRADDQVKIRGYRVE
                     LGEVQAGIAAHPLVAQAAVVAREDVPGDVRLIAYVVPMDEDGDLDGLPSAVREFTARRL
                     PEHMVPAAVVVLDALPLTGNGKLDRKALPAPDYAGTSASTGRRPSTLQEELLCLAFADV
                     LGLQSVGVDDDFFTLGGHSLMAVRLVSRIRTLLGIETDIRTLFEEPTVAGLATRLVGAK
                     AARAALVRGTRPERLPLSYGQRRLWIINQMEGPSSTYNIPVSSPMRGEVDTELLNAAFR
                     DVIGRHESLRTVYRVADGEPYQLILDLEELDWTLHVIDVEQEDLAGTVAEAERYAFDLS
                     AAEIPLRASLIRVGPEESVLAVVVHHITADGWSWGPMVNDLKTAYMARAEGRAPDWAPL
                     PVQYADYALWQREVLGDSADPDSVLAEQVAFWREELAGIPEELELPSDRSRPAVASYRG
                     HQTSLETSADVHARLAEMARAEGVTMFMVMHGALAVLLNRLGAGTDIPIGSAAAGRTDE
                     AMHHLIGYFVNTFVVRTDLSDDPTFREVLARVREAALGSLSHTDVPFEKLVEELSPARS
                     MARHPLFQVMFLLENAVGTKPDGPSSWTTGDSFEESVDGGVLVTRSSSVKVDLDFNMVE
                     VHDTDGTPAGLHGGLTASADLFDVESSVRMAERWVRLLASLAANPDVRLSEVDVLGAHE
                     RRRVLTEWNETGAPVQDATVVELFEAQAARTPDAIALVQGDVELGYAELDARVSRLARL
                     LRGRGVGPESVVGVVMDRGVDLVVALLAVMKAGGAYLPVDPEYPAERIAYVLADAGVPL
                     VLSHTAVAEVVPAGVPVVVVDDPSVVAELAVLSDVADVPVCGGVELESRNAAYVIYTSG
                     STGRPKGVVVPHGALVNHLFAAGERVGVAAGDRLVAVTTVSFDIAALELFLPLVSGASV
                     VLASREEVRDPSALTRLVLTSGASVLQAVPSLWRALLEEEGWPAGVRALVGGEALPREL
                     AQRFTDLGVRAVNLYGPTEATVWATSAEVASDVVSVGRPFANTRAYVLDRSMRPAPVGV
                     TGELYLAGAQLARGYVGRSGLTAERFVASPYAFGERLYRTGDLARWRADGELECLGRAD
                     DQVKVRGFRIELGEIEAVVAGHPSVGQAVALVREDVPGDQRLVAYVVPNRALAPEELDG
                     FAQAVGGVAQDRLPAYMVPSAIVVIEQFPLTPNGKLDRKALPVPEAAVREEAHHSVNSF
                     EANIGAAFAEVLGLESVGVDDDFFALGGHSLLAVRLVEALRERGVAMAVRDLFAAPTVG
                     RLMKRMSLSSVQDALDVLLPIREQGERPPFFCFHPAGGVSWCYMPLVRYVPEDVPLYGL
                     QARGLDGTSELAGSIAEMAADYITQMRSVQPSGPYHLLGWSYGGVLAHEIAVQLQAAGE
                     EVGALVLLDQYPWDSEEEAAMAAREKELDPEDEIDQLVDAVRLEAGGALGAVTDEEYRT
                     FARVLHNGRRIRRTHTHGRFDGDALLVVAKNGREEEGPTADRWAEHVTGVVSEAGVPCT
                     HYDLAKPEHLGLVWAEVSAWLGWEG"
     aSDomain        complement(20037..20702)
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35530_Thioesterase.1"
                     /evalue="7.10E-42"
                     /label="IE257_RS35530_Thioesterase.1"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1711"
                     /protein_start="1489"
                     /score="136.3"
                     /tool="antismash"
                     /translation="PFFCFHPAGGVSWCYMPLVRYVPEDVPLYGLQARGLDGTSELAGS
                     IAEMAADYITQMRSVQPSGPYHLLGWSYGGVLAHEIAVQLQAAGEEVGALVLLDQYPWD
                     SEEEAAMAAREKELDPEDEIDQLVDAVRLEAGGALGAVTDEEYRTFARVLHNGRRIRRT
                     HTHGRFDGDALLVVAKNGREEEGPTADRWAEHVTGVVSEAGVPCTHYDLAKPEHLGLVW
                     "
     aSModule        complement(20037..23936)
                     /complete
                     /domains="nrpspksdomains_IE257_RS35530_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE257_RS35530_AMP-binding.2"
                     /domains="nrpspksdomains_IE257_RS35530_PCP.2"
                     /domains="nrpspksdomains_IE257_RS35530_Thioesterase.1"
                     /final_module
                     /locus_tags="IE257_RS35530"
                     /monomer_pairings="Gly -> Gly"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(20448..20522)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0018"
                     /evalue="8.60E-15"
                     /label="NRPS-te1"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1574"
                     /protein_start="1549"
                     /score="46.9"
                     /tool="antismash"
                     /translation="QPSGPYHLLGWSYGGVLAHEIAVQL"
     CDS_motif       complement(20673..20702)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0017"
                     /evalue="1.80E-02"
                     /label="NRPS-beforete1"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1499"
                     /protein_start="1489"
                     /score="8.3"
                     /tool="antismash"
                     /translation="PFFCFHPAGG"
     aSDomain        complement(20769..20960)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35530_PCP.2"
                     /evalue="9.60E-24"
                     /label="IE257_RS35530_PCP.2"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1467"
                     /protein_start="1403"
                     /score="75.4"
                     /tool="antismash"
                     /translation="ANIGAAFAEVLGLESVGVDDDFFALGGHSLLAVRLVEALRERGVA
                     MAVRDLFAAPTVGRLMKRM"
     CDS_motif       complement(21015..21041)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0016"
                     /evalue="1.30E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1385"
                     /protein_start="1376"
                     /score="5.4"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     CDS_motif       complement(21270..21335)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0015"
                     /evalue="1.20E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1300"
                     /protein_start="1278"
                     /score="39.6"
                     /tool="antismash"
                     /translation="CLGRADDQVKVRGFRIELGEIE"
     aSDomain        complement(21300..22487)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35530_AMP-binding.2"
                     /evalue="4.30E-110"
                     /label="IE257_RS35530_AMP-binding.2"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1290"
                     /protein_start="894"
                     /score="360.0"
                     /specificity="substrate consensus: Gly"
                     /tool="antismash"
                     /translation="FEAQAARTPDAIALVQGDVELGYAELDARVSRLARLLRGRGVGPE
                     SVVGVVMDRGVDLVVALLAVMKAGGAYLPVDPEYPAERIAYVLADAGVPLVLSHTAVAE
                     VVPAGVPVVVVDDPSVVAELAVLSDVADVPVCGGVELESRNAAYVIYTSGSTGRPKGVV
                     VPHGALVNHLFAAGERVGVAAGDRLVAVTTVSFDIAALELFLPLVSGASVVLASREEVR
                     DPSALTRLVLTSGASVLQAVPSLWRALLEEEGWPAGVRALVGGEALPRELAQRFTDLGV
                     RAVNLYGPTEATVWATSAEVASDVVSVGRPFANTRAYVLDRSMRPAPVGVTGELYLAGA
                     QLARGYVGRSGLTAERFVASPYAFGERLYRTGDLARWRADGELECLGRADDQVKVR"
     CDS_motif       complement(21417..21506)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0014"
                     /evalue="1.70E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1251"
                     /protein_start="1221"
                     /score="49.1"
                     /tool="antismash"
                     /translation="PVGVTGELYLAGAQLARGYVGRSGLTAERF"
     CDS_motif       complement(21606..21629)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0013"
                     /evalue="8.50E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1188"
                     /protein_start="1180"
                     /score="6.1"
                     /tool="antismash"
                     /translation="YGPTEATV"
     CDS_motif       complement(21990..22049)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0012"
                     /evalue="9.90E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="IE257_RS35530"
                     /protein_end="1060"
                     /protein_start="1040"
                     /score="33.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVVVPH"
     CDS_motif       complement(22260..22301)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0011"
                     /evalue="2.90E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE257_RS35530"
                     /protein_end="970"
                     /protein_start="956"
                     /score="17.2"
                     /tool="antismash"
                     /translation="LAVMKAGGAYLPVD"
     CDS_motif       complement(22875..22991)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0010"
                     /evalue="6.60E-19"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE257_RS35530"
                     /protein_end="765"
                     /protein_start="726"
                     /score="60.3"
                     /tool="antismash"
                     /translation="REAALGSLSHTDVPFEKLVEELSPARSMARHPLFQVMFL"
     aSDomain        complement(23031..23936)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35530_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="9.10E-111"
                     /label="IE257_RS35530_Condensation_LCL.1"
                     /locus_tag="IE257_RS35530"
                     /protein_end="713"
                     /protein_start="411"
                     /score="361.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHITADG"
                     /tool="antismash"
                     /translation="ERLPLSYGQRRLWIINQMEGPSSTYNIPVSSPMRGEVDTELLNAA
                     FRDVIGRHESLRTVYRVADGEPYQLILDLEELDWTLHVIDVEQEDLAGTVAEAERYAFD
                     LSAAEIPLRASLIRVGPEESVLAVVVHHITADGWSWGPMVNDLKTAYMARAEGRAPDWA
                     PLPVQYADYALWQREVLGDSADPDSVLAEQVAFWREELAGIPEELELPSDRSRPAVASY
                     RGHQTSLETSADVHARLAEMARAEGVTMFMVMHGALAVLLNRLGAGTDIPIGSAAAGRT
                     DEAMHHLIGYFVNTFVVRTDL"
     CDS_motif       complement(23040..23129)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0009"
                     /evalue="2.60E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE257_RS35530"
                     /protein_end="710"
                     /protein_start="680"
                     /score="32.7"
                     /tool="antismash"
                     /translation="DIPIGSAAAGRTDEAMHHLIGYFVNTFVVR"
     CDS_motif       complement(23397..23435)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0008"
                     /evalue="3.50E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE257_RS35530"
                     /protein_end="591"
                     /protein_start="578"
                     /score="19.4"
                     /tool="antismash"
                     /translation="QYADYALWQREVL"
     CDS_motif       complement(23484..23549)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0007"
                     /evalue="1.30E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE257_RS35530"
                     /protein_end="562"
                     /protein_start="540"
                     /score="27.4"
                     /tool="antismash"
                     /translation="VHHITADGWSWGPMVNDLKTAY"
     CDS_motif       complement(23754..23867)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0006"
                     /evalue="2.20E-12"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE257_RS35530"
                     /protein_end="472"
                     /protein_start="434"
                     /score="39.3"
                     /tool="antismash"
                     /translation="TYNIPVSSPMRGEVDTELLNAAFRDVIGRHESLRTVYR"
     aSDomain        complement(23985..24182)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35530_PCP.1"
                     /evalue="4.30E-26"
                     /label="IE257_RS35530_PCP.1"
                     /locus_tag="IE257_RS35530"
                     /protein_end="395"
                     /protein_start="329"
                     /score="82.9"
                     /tool="antismash"
                     /translation="EELLCLAFADVLGLQSVGVDDDFFTLGGHSLMAVRLVSRIRTLLG
                     IETDIRTLFEEPTVAGLATRL"
     aSModule        complement(23985..25148)
                     /complete
                     /domains="nrpspksdomains_IE257_RS35530_AMP-binding.1"
                     /domains="nrpspksdomains_IE257_RS35530_PCP.1"
                     /locus_tags="IE257_RS35530"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(24138..24176)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0005"
                     /evalue="1.40E-01"
                     /label="Cy4"
                     /locus_tag="IE257_RS35530"
                     /protein_end="344"
                     /protein_start="331"
                     /score="5.5"
                     /tool="antismash"
                     /translation="LLCLAFADVLGLQ"
     CDS_motif       complement(24240..24266)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0004"
                     /evalue="1.30E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE257_RS35530"
                     /protein_end="310"
                     /protein_start="301"
                     /score="5.4"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     CDS_motif       complement(24492..24554)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0003"
                     /evalue="4.00E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE257_RS35530"
                     /protein_end="226"
                     /protein_start="205"
                     /score="34.9"
                     /tool="antismash"
                     /translation="FQGRADDQVKIRGYRVELGEV"
     aSDomain        complement(24519..25148)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS35530_AMP-binding.1"
                     /evalue="5.20E-49"
                     /label="IE257_RS35530_AMP-binding.1"
                     /locus_tag="IE257_RS35530"
                     /protein_end="217"
                     /protein_start="7"
                     /score="158.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DLGNTVVFASLTTGGELHVLEEGAVTDPVAVSSYLVEHGIDFLKA
                     VPSHLAALASVTGVEGVLPGRSLVLGGEAAAPALVRELVEHGGDGVVFNHYGPTETTIG
                     VATTRLEVSDADAGLVPVGAPVANTRFYVLDASLRPVPVGVVGELYVAGVQLARGYVKR
                     TALTAERFVANPFEPGLRMYRTGDRACWTEDGRVVFQGRADDQVKIR"
     CDS_motif       complement(24636..24725)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0002"
                     /evalue="9.40E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IE257_RS35530"
                     /protein_end="178"
                     /protein_start="148"
                     /score="49.9"
                     /tool="antismash"
                     /translation="PVGVVGELYVAGVQLARGYVKRTALTAERF"
     CDS_motif       complement(24840..24863)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS35530_0001"
                     /evalue="4.30E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="IE257_RS35530"
                     /protein_end="110"
                     /protein_start="102"
                     /score="6.9"
                     /tool="antismash"
                     /translation="YGPTETTI"
ORIGIN
        1 acgcgggacc accagatctc gtgaccgtgc gtggtggcga cgatgcgtcg caccccggcg
       61 tcacgccgaa gggccggtgc catcagcgcg agtggggccg cggccccgaa ccacacccgg
      121 tcgcagccgt gggcgcgggc cacctcgacg gccctgcggg tgacgcggga ggtcggcagg
      181 agcatgcggg tggagtcacg gacgacgggg aaggggagcg tcgcgtcgta ggcggtgtcg
      241 cccgcctcgt gcgaggtgta gacgacgacg tcgtcggcgg gcacccgggt ggccatggca
      301 tgcacgaagg tctctatgcc gccctggcgg ggcgggaagt cgttggtgat gacaagagtg
      361 gaacccatga cagggcaagt tccttcagtc gtgggtgggc ggacgagtcg tgaagaggta
      421 gttacggaag tcgtccgtga ccgcggcctc ggggtgccat cccccttcgc gccagcggta
      481 catggagtag ccgagccctc gcaggcccgc gacgaggccg gccgggcggg cgtcgtactt
      541 ggcgaggtga cggtcctcga tctccagcag cagcgacgga cggtgccgca gcagagtgcg
      601 gcgggcgccc gcgagcacgg cggcctcggc tccctcgacg tcggccttga tgaagtcgac
      661 gcggtcgagg cccaagtggt ggcacaggcc gtccacggtc cggacggccg tggccacgga
      721 gcgggaccgg gcgaactcgg tgttgggccc cgggccgttg gccccctccg tgaggtacgc
      781 ccgcccgtgc accggcagca gacggcgtcg gggcaggctc atcgtgccgg gctgggcgcg
      841 agccgccagg gccacgcggt gcacggtgac gttgtcgcag ccgaaggcgg atgcggcggt
      901 gcgcagccag gccgccggac cgggcagggg ctcgatgctg tggacggagc cttcgggtcc
      961 gctgagtgcg gacagggccc aggtgtagag gccgtactcg gcaccgatgt cgaggcagac
     1021 ggcacccggc cgcacgaagg gccgcagacc cgccacttcg tcctcgacga aggagaagcg
     1081 cgacgaggcc caggagagcc cgcccgccac ggccgatacc cgtacgcccg cacgcgcggg
     1141 ggccggacgt acgggttcgg acggatacgg cggccggggt aaccggccgg tggccgaaac
     1201 cctgttcgtc gccatgtgat cagactccta cgttcatcaa cgcacggggt gcggcgtacc
     1261 gctcggaaag gatctgcgcg ttcgcgctct cgccgatcaa actattgatc acaccctccg
     1321 attgtcatca gtccgcggat gtaaccccgg agaacgacag gccggagcgg atcggtcggc
     1381 cggaattcac gtcgcgcgca tccgaatggg gatttcactc ggccgaggca ccggacgacc
     1441 ggtcgtcgcc gcggtctccc ggaacgggaa accgctcccg gtcgggggtt tgtcgtggcg
     1501 gtgaccggcc gacgagcggg gtgtttcggc ggtgtcggga aatcaggagt ccatcgctcc
     1561 ggaaaggagc ggcggggatg tctgcccgta cgcgaacgca tgccgattcc ggaggccccc
     1621 gtgcgcgcgg cccgtgctct tcgccgaggg ccgcacgtgg aacgggaacc ctcgccgtcg
     1681 aggttccgag cgccgctggg ccgtctcttc cggatcctgc ccggagtcgc agcccggtcc
     1741 ggtaccggcc acgcgcgggc tccgagggcg gtgcaggcgc tcgatcgccg tcgggggtgc
     1801 ggtcggcacg ccggggtgcg ccgtgccggg cacaccggcc ggccctgcgg gcaacgggcc
     1861 cgagggccgg ccggaaccgc tcgggggccg accgtcagca ggccgcccgg tgcccctcgg
     1921 gctgagcccc ttcgtccagc tcccgcgcga actccatcca ggtctcggcg acctggcgcg
     1981 cgaggtcgac caccagggcg ccacagtgcg acggcaccac cgtggtcagt tcggaccact
     2041 ccctggtccc gatggcgttc tgctggagca gcctcagcag ttgccgcccc tcctgcttgt
     2101 gccgcagcga cgggtcccgc agcagcctct ccacgacggc ggccggcgga gacggcaccg
     2161 gaggcatccc acgcacggtt ctcggcctgt cggcccgggc tgctccgctc atgccggtcg
     2221 cttcggccgc agcgggcggc tgtcctgagg cgagccgctt gcggacgtcg ctgacggtgg
     2281 ccggcgagat gcccgcacgc cgcgcgacct cgcgcagcga cgtcatcgga tcctcggtga
     2341 tgatctcggc ggcccgtctg cggccctccg cactgttcaa cgggcgtacc ttgccgtcga
     2401 gtccgacacg ggcgaccggc tgctgccccg gcccggtcat ctcgcgccgg atcttcgcca
     2461 cggtccgcgc cccgaggccc gcggaccgcg cgatcgcccg gtccgaactg cgcgggtggg
     2521 accgtatgat ccgctccgcg gctctgcgcc ggtccgcgtg cggcagcggc aggccgtgcg
     2581 ccacgttcgc ctcgacggcg cgcaggaacg cttcttcagc agtgccgtcg aagaactcga
     2641 cgtcgatcga ctcctggccc ttgagcgtgg cggccatcag gcggtgcgtt ccgtcgatca
     2701 cgcgcatcgt gcggcgatcg accaggatcg gaggcagcgg ggcgtcgagt tccgccagtc
     2761 tggcggcgtg gtcggcgtcc ttcccctgcg accgcgggga gtcccccgag agaatcagac
     2821 cgatcggcac ggtcacgacg tgcgggaggg cagcgccttg cgctgctggg aatgtgggac
     2881 cggtttcggt tgccgcccca tcggatgggc gggcatagga catgctcaag tagttcaccc
     2941 cgttgaatag cctggtacat ctactgctcg cgcagctcac ggccctggag tcgaccgcgg
     3001 gccggcagcg cggttcccct accgcaccac ggtcccgctc gatccggcgc tcgggcagtc
     3061 gtcggacatg gccagtcccc ccgccatccg accgccctct acaccaccac tcccttggtc
     3121 gtcgagagtg ttgctccagg ttgtgatcaa atcacaaccg gtatcccggc ggtacgtcaa
     3181 atccgcctac gcgcgcatgc cgaagcgctg cctgggcagg ccggcttccg cgcccacggg
     3241 gcgcatgttc tcgtcgagct cctgggcgaa ttccatccag gtctccgcgt actggcgcgc
     3301 gaggccgaca acgctgtccc gggcgtgtga gggcacgacg gcggccagtt gggcccacgc
     3361 ccggtcgccg agcgcaccct gctggagcag gcgcagcagc tggcgtcccc cctccttgtg
     3421 tcgcaaggag gggtcgcgca ccagcttctc catcaactgg accgggtcga gctgcaccgg
     3481 tctcgccttg cggacgggcc gcgctctgga catctgcctg gggatggacg gcagggtccc
     3541 gtccacgtcc ggcgcgaggg caacgggcct gcgctccgcg acgggctgct gcccggccag
     3601 caaacgcctg cggacgtcac tcaccgtcgc gggcgagatc cccgcacgcc tcgccacctc
     3661 gcgcagggag gcttccgggt tctcggcgat cagttcggcg gccttccggc ggccctcggc
     3721 gctgctcagc ggccggaccc tgccgtcctg cccgatcctg acggccagtt ggcccgcctc
     3781 gccggcggaa gcccgccgga tggcggccac cgatttggcg cccaggcccg aagcccgggc
     3841 gatggcgcgg tccgacatct gcgggtgggc ctcgatgatg cgcgtggcag cagccctgcg
     3901 gtccttctgg gagagcggga ggccgtgcgt cacgttcgcc tcgaccgcgc gaaggaacgc
     3961 ctcctcgggc gttccttcga agagttccgc gtcgatcgac tcctggcccc tgagacaggc
     4021 ggccagcagc cggtgcattc cgtcgatcac gcgcatcgtg cggcggtcca cgaggatggg
     4081 gggtaacgga acgtcgagct ccgccagccg ggtcacgtgc tccgcgtcct gcccgtccag
     4141 acggggcgac tctccgggaa cgagtaaggc gatgggcagg gagacgatct cccttccgcg
     4201 cgcgtcggcg cctgcggcgg ttctgcccga gtcggtggcc gaaccgggtc ccacggaatc
     4261 catcccactt gggcaggccg gactcattct cgtatccccc attgagtaga caggtccttc
     4321 tctgctacga gcacgccggg cgcctgactg tcaagcggtc agaccttcgg tcaccaacgg
     4381 cgcccgggcg tgcgacagca acgtccatca ctgtcataaa ttcgacaaaa agcgcaggta
     4441 agccaaggct cacctaaccc cggatcgcat aagcaatgtg cgaactccgt catcgtcacc
     4501 cgcgagtcat tgcactgtcg agagctgatc gatcgaaact tgatcgaacg aacagccttc
     4561 acatcgcagc ccggcccccg cgcccaagcc gcgttcgaat gaaattcgcc ataggggata
     4621 catcgcgcca atcaaaggcg cgttcaactg tcgcttcgcg ctggttgaac accgctcgtg
     4681 cccacggcac acggccgtgg gcccgatggc ggtccacccg gcgcccgtag tgccgatgcc
     4741 gtcggccatc cggggatggc cgacggcatc ggcacggcgg gctacttctg cgccgccatc
     4801 gcctcgatca ggctcttggg ccgcatgtcg gtccaggact tctcgatgtg gtcgaggcac
     4861 tcctggcgtc ccgccttccc gaacaccgac tcccagcctt cgggcacgtc gacgaagacg
     4921 ggccacagcg agtgctggcc ctcgtcgttg accaggacca ggtactcggc atcgggatcc
     4981 tcgaacggat ttgtcaccac gccgtccttt cttgggtaca tgggatgcat ggcatcggtg
     5041 gacgcgctcc cgggcacttc tcccggcctc gcccccaccg cggacggccg tccggcgcgg
     5101 tgccgggcca gccgggggcc actatgacct gaagccctgt cggcgcgtca atcaggactg
     5161 cggacgctgc gctccgggct gttcaactgc ccccagcgcg ctggttgaac agggccgagg
     5221 cgccgggcgg ccaggtctca cctgcccttg atcgacgcgt ccgcccggtg ccatcgtgga
     5281 acgctggcat gccacatcac caccgcgccg tgtccccgtc ggcactcacc gccgagcgct
     5341 ggaacgcccg tacaggcatg gccggggcgc atctcgatct ccggctccgg acccttcgcc
     5401 cccgaatcct tctcctcgac ttccaggagg ccgtcttgcc catgcccacc gcccatcagg
     5461 gagcgccgcc atgccgttcg tgagcaccaa cgggatccgg ctctcctacc agcggtcagg
     5521 ccgaggggag ccggtgctcc tcatcatggg ctccggcgcc gcaggccgcg tgtggacgat
     5581 gcaccagaca cccgctctgc accgggcggg ctacgagacg atcgtcttcg acaaccgggg
     5641 catcgcgccg tcctccactc cgcccggcga ctactccctc gcggacatga ccgccgacac
     5701 gatcggactg atcgaggcac tggacatcgg gccgtgccgc atcgtcggca cgtcgatggg
     5761 agccatgatc gcccaggagc tcgcgctcgc ccgccccgaa ctggtgcgct gcgccgtcct
     5821 catggcgacc cgggcccggt ccgacgccgc gcggcgcatg atgcgggagg cggaccgcga
     5881 actgcgggcc tccggtatca ccctcccgcc caagtacgag gccgtccgca ccgtgctgga
     5941 gatgctgtcc ccgaccacgc tgaacgacga agccgcggcc tccggttggc tggagatctt
     6001 cgaactgacc tcgggcagct ccgccccggg ccaggactct gtcgacacgt tcggcgaccg
     6061 ccgcgaggcg ctgcgcgaac tcacggtgcc gtgccgtgcg atcgccttct ccgacgacct
     6121 catctgtcct ccgcacctgg tcgccgaggt ggcggacgcc atcccggact gcgactacgt
     6181 ggagatcccc ggctgcggtc atctcgggaa cctggagaac ccggacgagg tgaacaccgc
     6241 ggtcatcgag ttcctcggaa agtactgacc gcccctcacg agcacgaagg acgttccatg
     6301 gcaaggaaaa agagcgcggc cgaagacaag gcgcgactac ggttcgacga cggctcgatc
     6361 acccgtcggc ggatcaagca ggggacgttc cggcgcatcc tcccctacgc cctgacctac
     6421 ccctggccga tgacactgct ggtgatcagc acggtcgtcg atgccgcggc caccgcagcg
     6481 ggccccctgc tcctgaagat ggtcatcgac gacggcatcc tgcccggccg gaccgacacg
     6541 gtgatctggc tctgcctggg cgtgaccggc ctggcgctgg tcgagggtgc cgccatgtac
     6601 gtacaggcct gggcctcggg ccggatcggc gaaggagtcg tctacgacct gcgcaacagg
     6661 gtgttcacgc acatccagaa gcagtcgctg accttcttca cccgcgcgca gaccggagcc
     6721 ctcgtcagcc ggctgaacac cgacgtcgtc ggggcgcggc aggcggtgac cgtcctgctc
     6781 tcccagaccc tgtccgtgct cctctcgctg gccctggtgc tggccgcgat gttctacctg
     6841 tcgtggcaga tcaccctcgc cgccctggcg atgatcccgc tcttcctgct cccggcgcgt
     6901 ctggtctcgg gccggctcca gcgcctcacg cgggagcgga tggagctcga cggcgacatg
     6961 agctccctga tgagcgagcg tttcaacgtc tcgggcgcca tgctcgccaa gctctacggc
     7021 cgcgtggagg acgagtccgg cctgttcgcc cgcaaggcgg gccgcgtgcg tgacatcgcc
     7081 gtgctgggga tcctctacgg gcgcaccctc agcatcgtcg gcaccgtgct gacggcgatc
     7141 accacggccc tggtctacgg actgggtggc gtcctcacca tcgacggcac cctggccctg
     7201 ggcacgctcg tggccatggt cgccctgctg atgcggctct acgggccgat caaccagctc
     7261 tccagcatgc aggcgaccgt gatgacggcc ctggtcagct tcgaccgggt cttcgaggtc
     7321 ctggacctcg agccgaacat agcggagcgg cccggcgccc gggacctcgc cgacgcccgg
     7381 cccgcggccg ggagcggcga ggcgccggac atcaccttcg agggggtcag cttccgctat
     7441 ccgagcggcg acgaggccgc gctcgcctcg ctcgggccgg ccggcggcga tcgccccggc
     7501 ggggcggacg aggcgtggac cctgcagaac ctcgacttcc acgccccggc cgggaaactg
     7561 accgcgctgg tcggcccctc gggcgccggc aagaccacca tcacccagct cgtgccccgg
     7621 ctctacgacc cggatcgggg caccgtccgc atcgccggcc aggacgtcag ggacctcacc
     7681 ctgcagtcgc tgcgcgacac gatcggcgtg gtcacccagg acgcccacct gttccacgac
     7741 accctgcggg ccaacctgga gtacgcgcgg cccggtgcga gcgagcagga actgatcgac
     7801 gcctgcgagg cggcgctgat ctgggacacc gtccgcgccc tcccggacgg cctcgacacc
     7861 ctggtcggcg accggggcta ccggctctcc ggcggagaga agcagcggat cgcactggcc
     7921 cggctgctgc tcaaggcccc gtcggtcgtc gtcctcgacg aggccaccgc gcacctcgac
     7981 tccgactcgg aagcggcgat ccagcgtgcg ctcaagacgg cgctggccgg acgcacatcg
     8041 ctggtgatcg cccaccgtct gtccacgatc cgcgaggccg accggatcct ggtcgtcgag
     8101 gccggacaga tccgcgaaca gggcacgcac aaggagctgc tggccgccga cggcctctac
     8161 gccgccctgt accgaaccca gttcgcgcag gacgaaccgc tcgaggaggc tgcggtgctc
     8221 gacccggcgt agcactgacg tggctcccgg gcacgacgaa gctgccgtcc gnnnnnnnnn
     8281 nnnnnnnnnn nnnnnnnnnn nnnnnnngct tcgtcgtgcc cgggtgtggc gccgcgcccc
     8341 gggtcggggt gcatgccgcc cggggcagcc ctgccaactg agcaggcgcg ccagttgaac
     8401 agcggacggg cacgcgccac ccgggccgtc tcttccggat cctgccggac ccgcggcgcc
     8461 cggcaggatc cgaaacagac ggcctaacgc cgccgggcga agtcgtgcac caccacggcc
     8521 gccgccccga cggccgggtg acgctgcagg accgcttcga tctcaccgag ctccatccgg
     8581 accccggcga tcttcacctg ccggtccacg cggccgaggt actgcagggc cccctgcggg
     8641 aggaccgtga ccgcgtcacc ggtccggtag agccgcccgg tgggcgtgtc ggcgaacggg
     8701 tcacggaaga aggcgtcccg ggtccggtcg tggtcgtgga cgtagccgcg ccccacgcag
     8761 accccgccga cgaacagttc cccggtctcg cccggcgcgc aggcgtgcca gccgtcgtcc
     8821 tcgcgacgca ggacgtacaa ctggcagttc acgaccgggg tgccgatggg caggcgcagc
     8881 aggccgaggt ctgcggggag caccgtgtgg tgggtgacat cgtcggagca ctccgtcggc
     8941 ccgtaggcgt tcaccagccc ggcctggggc atctcctgga gccagcgccg ggccacctcg
     9001 gtcggcagct cttcgccggt ggccagcatc caccgcaggc cttccagacg gcccgccgcg
     9061 ggggcggccg ccaggtcgtc cagcagcagc cgcaccatcg tcggcaccag ttcgacgacg
     9121 gagacgccct gttcaccgat gagccgcgcg aaggccaccg agtcatgggc cgtggcgtcg
     9181 tcgaccacgg cgacctcgcc gccgacgacc agcgggcaga gcatctgcca gatcgagatg
     9241 tcgaagccga gaggggcggt ctgcgcgacg acgtcgcgct cggtgagtcc gaggtcgacg
     9301 accttggcga agaggtggtt gagcatgccc tggtgctcca cgaccgcgcc cttgggcctg
     9361 ccggtggatc cggaggtgaa cagcacgtac cgaggctggt ccggggactc cagccgggcc
     9421 ggtccccggc acggttcgca cgaggccgcg tcggcagcgc gcacgacccg tacgccggcc
     9481 tcccgcgccc cctcggcgag agaggcggag accgcctccc ggtcggtgtc gagcagcatc
     9541 acggcgccgg cctggccgat gacatcggcc acccgccggg ccggccagtt gccgtccgcg
     9601 ggaaggtaga gcgcccccag aagttcggtg gccaggaagg cggcgacgac cgtgctgccg
     9661 cgttcacctc cgaccgcgac gaccgtgccg ggggtgacgc cctcccgctc catcaaggtg
     9721 gccagacgtc gtgcctccac ggccagttcg gcgtatccga gccgacggtg ggcatccctg
     9781 accgccgggc ggtcaccgtc cagggcgaag cgttcgaccc tggtgatcac ggcgtccgtg
     9841 aggtcgaccg gatggtcgcg ggtcaccgcc agcgcgcggg cgtgccggat ttcacccggg
     9901 gagatcgcca gttccgggag ctcggtcgga ccgagcaggc catccacgat ggtcatgaat
     9961 ccgctccttg agatcggcac caatagccgt tattgactgt tcagggaata gccggatctt
    10021 gcaggccaac tttccctcca gtacggtaat ccatgctagg gcgatcaagt attgctttca
    10081 tcgcccgatg gaagacactg caaaatagca gtggacaacg gcagttgatg gccgatcgag
    10141 gttcccgaat tacctctcga cgccgactgc cgctccgatt tcaaccactt ccatatcccc
    10201 tacccgtcct gcagagggtg tccggcactg tgcccatcat cagctcccct catgaattca
    10261 atgtcgagga cctctacata gatttacgca ggctgaacgg cactccgctg tacctgaagt
    10321 gcgaggggtt caacttcgcg gggtccatca agttgaaggc cgccgctgaa atgctcgacg
    10381 ccgcggagct cgaaggcctc atccgcccgg gctcggtcct ggtggagtcg tcctcgggca
    10441 acctgggcgt cgcgctggcc atcatcgcgg ccgaccgggg ctaccgcttc gtgtgcgtca
    10501 ccgatccccg ctgcaacccc accaccgtgc ggctgatgcg ctcactgggc gcggacgtcc
    10561 gggtgatctc gaagcaggat gccaacctcg gatacctcca cagccggatc cagtacgtcc
    10621 gcgacctgtg cgcctccgac gaccgctacg tgtggctcaa ccagtacgcc aacccgaaca
    10681 actggcgtgc ccactacgag cagacggcgc cggagatcga gcgcagcttc ccggacctgg
    10741 aggtgctgtt cgtcggcgcg ggtaccacgg gcaccctgat ggggtgcgcg cgctacttca
    10801 aggagcgccg caggcccgtc acgatcgtgg ccgtcgacgc cgtcggctcg gtcaccttcg
    10861 gtggcgtccc ggagcgccgg gtggttccgg gcctgggaac cagcacccgc ccggccctgc
    10921 tcgacgaggc gtgggtcgac gacgtcgtgc acgtcctgga gaccgacacc atccgcgcct
    10981 gccacagcct tgccgcccgg gggttcgtcc tcggcgggtc gaccgggacc gtggtcagcg
    11041 gcgccacccg ctggctgggc gagaagtacc cgggggagga cccggtcgcg gtcgcgatct
    11101 cccccgacct gggcgagcgc tacctcacct ctgtctacga cgagacctgg ctgcgcacgc
    11161 acttcggcca ggccgacctg ttcaccgaca ccgactggag cccctatcca tgacccagcc
    11221 cccttcgttc tccgtcatct ccggcgcgca ggtcgccgac gtcctgaccg gccacgagaa
    11281 gcaggtgacc gcgatggtcg agcaggcgta ccgcctgcac ggcgagggcc tgacggtgaa
    11341 cccggattcc tacttcctcc gcttccccga gcggccttcc tcccggatca tcgcgctgcc
    11401 cgcgtcggtc ggcggcgacg tggacgtgca cggcatcaag tggatctcct cgttccccga
    11461 aaacgtcgcc gccggtatcc cgcgggcctc cgccgtggtc gtcctcaacg acaccacgac
    11521 cggctacccg ctggcctgcc tggagagttc cgtcatcagc gcctcgcgga ccgcggcctc
    11581 cgcggccctg gcggcggtga cgctcgccga ccggcgcggt gtgacgccgc gccgcgtcgg
    11641 cttcatcggc gtcgggctga tcgcccgcta cctgcacacc tacctcgtcg ccaacggcct
    11701 gtccttcgac gaggtgggtg tcttcgacct ggaccgggga cacgcggagg gcttcgaggg
    11761 atacctgacc cgctccgggg agggccgggt gacgatccat gagagcgccg agtcgctcat
    11821 cgccggatcg gacctgatcg tgctggccac ggtggcgggc gagccgcaca tcctcgaccc
    11881 ggaactgttc tcccacaacc cgctggtcct gcacgtctcg ctgcgcgacc tctcccccga
    11941 gatcatcctg tcctcctaca acctcgtcga cgacgtcgac cactgcctga aggccaacac
    12001 ctccccccac ctcgcggagc agcggaccgg caaccgggac ttcgtcgacg gcaccctcta
    12061 cgacctgctg gagggccgca ccactccccc ggccgaccgg cccgtcgtgt tctccccgtt
    12121 cggcctggga gtgctcgacc tggccgtggc caagtacgtc tacgacgagg tggacgcggc
    12181 cggagcgctg ctgaccgtcc ccgacttctt ccacgagatg aagcgctacg gctgaacccg
    12241 gtacggcccc cggacaccgc gaagggcccg cctgtccggc gggcccttcg tcgtgtgctg
    12301 gcgagcacgg ccgccgtcag ggccggccgt ctgcccggga cctgatgaag tcggccagcc
    12361 gctccacgcc ctcggcgata ctggaatgcg tcagataact gacggagagc cgcagactgc
    12421 gctcgccgcc accctgcggg tagaagtacg acatgggcgt ccagatgacc ccgtactcct
    12481 ccgcgcaggc ctcgagcgcc gcgttgtccg cgacgaacgg cacgtcgacg gccaggaaga
    12541 agcccccgct cggctcgttc cagcggatgc cgagggcttc gcgctccttc ggcgggaagc
    12601 accggtcgag ttcccggagg gtggcccgca tggcgtcccc gtagtacgcg gccgtgcccg
    12661 cgttgaactc cgaggttcgc ccgcccgcgg cgagcagcat gcccgccacc accgcctggc
    12721 tgagcgggga ggtgttcacc gtcaccatgg acttgatcct ggtgagttcg tccgcgagca
    12781 gtccggtgga tccgtcggcg ccgacgacga cctggtccgc gaccacgtac cccacccggg
    12841 ctcccgggaa gagggtcttg gagagcgatc ccagatggac gacgtgacgc ccgcggtcca
    12901 gcgacttcag cgtcggcagt tgcctgccgg ggctcacggc ccggtacggg ctgtcctcaa
    12961 ggatcaggat gccgtggcgg gccgccaggt cgagcagctc cttgcgctgc tccagcggca
    13021 tcgtcgtccc ggacgggttg gagtggtccg ggaccacgta gaacgcccgg gggcggcgcc
    13081 cccgggcccg ctcggcgagg atcgccgcct ccaggtcggc gcagcggaat cctccggccg
    13141 tctcctcgac cgccgtcggc acgatgtcga acagccgggc cgctcccgtg atgcccacgt
    13201 agcaggggct ggagaccagc agcacgtcct cgggaccggc gatgagcgcc cgcaccgcca
    13261 ggagcatcgc ctcctgggcg ccgacggtca ccacgacgga ctccgcgggc acgtccgtgc
    13321 cctcgtccgc ccgcaggctg tcggcgatca actcacggat ctggccggcc gtcggcccgt
    13381 actggaagag ggccgagcgg atctcgtcgg gcgaggcccc gccctccgcc agatggtcca
    13441 ggtagcggcg caggtgggtg aagatctgct cggtctcgaa gaagccggcg taggggcggc
    13501 ccggcgcgaa ggagatcgcc cccgggtagc ggtgagtgat ctcgttgagg aagttcatcg
    13561 tgtcgagcac cgggtcgctg acactgccgt gcagatcgtc ccgtcgcagg tcgcccgtcg
    13621 gccgctcgtc cccgccgcct ccggggcgcc gggtacgggt gggccgccgc ggtgtcgccg
    13681 gcggcgtgtc cggcagcccc ggaagccgca gcaggtccgg gcccgcgtcg gcgagcgcgg
    13741 cggtgccggt gagtgtcatg gcatcggcaa gttcctcggc gaccagcccc aggacgtgct
    13801 gcacgccgtg ttcaccgctc acggccaggc cgtgcaggac cggccgcccg aggagcaccg
    13861 cgtcggctcc gagtgccagg gcggcgagga cgtcggtacc gcggcgcacc ccgccgtcga
    13921 ggagcagcgg tacggcgccc gcgacggcgt gcgcgatctc ggggagcacc tccagggtcg
    13981 ccggggcccg gtccagctgc cgcccgccgt ggttggacac caggatcccg tcgaccccgg
    14041 cggcgagcgc gctgcgcgcg tcggaggcgg tgaggatgcc cttgaccagt acgggcaggg
    14101 agctgatgga ccgcagccag tcgacgaccg accagtcgag ggacgggtcg aactcggtgc
    14161 gggcgtgacc gctgggcgag gagaagcccc cgccgaccag gttggccggg acgacaccgg
    14221 tgggcagccg gaagtcgttg cgcaggtcgc gcagcctgcg gccgaggtgc ggagcgtcca
    14281 cggtgagcac cagcgcctcg aaaccagccc gctcggcgtg ctcgacgagc ccgcgcgtcg
    14341 tgtcgcggtc acggaagcag tacacctgga gccagagcgg cccggaggcg gccgccgcga
    14401 tgtccgcgaa ggtgcggctc gcgaaggagc tgacgacgag ggcaccggca cgtcccgcac
    14461 ctcgggcggt ggcgacctcg ccgtccgggt gggccagggt gtggtaggcc atcggcgcca
    14521 cgccgagcgg caccggccag gtccgtccga ggatctcggt tccggtggcg ggagcgccca
    14581 tgccggtcag caccctgggg cgcagtcgca cctggtcgaa cacggccggg ttggccgcga
    14641 gcgtacgttc gtcacccgcg ccgcccgcga tgaagtccca tacggcgggt tcgagtcggc
    14701 gccgcgccag ggcctcgtaa tcggcggacg tcagcgggcc ggcggcaccc atcaggagga
    14761 cagccggtca cgctcgacgg cctcgtacag ggcccggatg ttggcgctgc cgaatccgcg
    14821 cgagccctgg cgctggatga gctcgaagaa gagcgtgttg cgctcgtacg gcgagcgggt
    14881 gaacagctgc agcaggtggc cccactcgtc gcggtcggcc agtacctgcg ccttgcgcag
    14941 ctcggctatc tgctccgcca tcccttcgaa ccgctcggcg agcatgtcgt agtaggtgtc
    15001 cggggtgttg aggaactcca cgccccggtc ccgggcctcg ccgaccgagg ggatgatgtc
    15061 gtcgacgagg aaggcgaggt gctgcgctcc cgggccgccg ttgcgctcca ggaaagcgtc
    15121 gagctggccg ggttccttgc ccgggtcggg cgcgacgagg gtgaaggtga cccggccgga
    15181 tgcgctgcgc accacgatgg agtccatcgc ctggccgccg acggccacgt actccgagga
    15241 gtagcgggag aagccgaagg catcgcggta gaagtcggcg tactcctcga gggtgccgcc
    15301 cgcgaggcag accgcgatgt ggtccagcag ccggatgcgg gagggctcgg tggaggtgat
    15361 ctcagggctc ggggtccagc gacggccgtc ggcgagcggg ccgccgggcc gggcgggtgc
    15421 gggcagcagg gtgtgggtga cgctgccgaa gcccgcgacc acgacgttgc cgcggggtga
    15481 ggcgagcggc acggcgcccg ccgcgaccgc cttcgcttcg gccgccgccg ggtcgtcgca
    15541 ggtcatggcg atgtcggcga tgccgtcacc atggctgtcg aggaacttcc agatgccgcg
    15601 gcccgaggtg acgaccaggc ggacgtctcc ctgctgcagc aggatggaac tgcggtccac
    15661 ctccaccgag tccgcgactc tggtgaagcc gagggccgag acgaagtagt cgacggcggc
    15721 gactttgtcg gatgcgaaca attcgacata cgagatgtcc tgcacagcca tggtgctagc
    15781 tacctcctga acggccgacg gccggtggtg tttcgtgggt gacgtggctt tgctgagcca
    15841 ggcaccgggg cgggggcggg cgggaccccc ggggctccgc agatgacgca tcgcgggtgt
    15901 cccgcccgac ggcccctacc gacgccggct gactaccaga cccattcctg ctgcttgaag
    15961 aggtggcccg cggtgatgtc gcggtccttg caccaggtga ggaactcctc gatctgcttg
    16021 atctggtagg tgtcctcggt gtaggtcgtg gccatgacgt ggcccagcca gtcctcttca
    16081 cccatggcgt agacgtacgc ctcggtggcg ccgagctccg tcatgatggc ggcggcctgc
    16141 tccgcgttgg agccggagag cttgcgcgag ttgctcatct tcttggtgac cgggatggtc
    16201 agcagcgcct ggtagagcca ggtgagcggt gcgccgtcgc actccatgcc gaggaaggcg
    16261 atgtcggcgg tgcccaggtg cgacttgatg tagcggtaga gcgcgggctc gatgcccgag
    16321 gagtcggcgc cgatgaagac cttcttgccg gccagttcgg cccagtaggt cgacttggcg
    16381 cggatgtcca ggtcgcagtg ctcaccgagg aacggcgtgg ccgtgatctt gccgccgggg
    16441 aactcgacct cgtcgaagtc gtcgacctcg atgacgttga agccctggtt gcggagcatg
    16501 tgcgccatcg acgggtcggc gaggttgccg cgcgaggagc gcggaacgac gatcgcgccg
    16561 aggcggccgc gcagctggag aagcgtctcc aggacgatgt ggtcctggtg accgtgggtg
    16621 atgagcacca ggtcgatgta gtccggcagg tcgtccaggg tgtagcggtc gcccgcggtg
    16681 ctgtcggcgc tgatgaacgg gtcggtgacg atggcggcct cgggcgtctg gagcaccagg
    16741 caggcgtggc cgaagtagcg gatgcggccg ccggcctcga tgtgacggtc cgcggcaccg
    16801 ctcggggtgt cgctgagcat ggtggccagg tgggcggtct gggcctcgtc gagctccagc
    16861 gcctcgctca ggtgggcgag ggtggtgccc tgcacccggg ccttgaacag ctcggtgaga
    16921 ccggggtggt tgaacgggat gtccagctcg agcacgtccg gcgaggggag gcgcggggtg
    16981 ctgaggatga acgggcgctc gatgccggtc tcgaaggaga gctgcaccga ctggcggccc
    17041 tggtcgtaga cctcgctctt gtagacgacc ggctccatga agcgcatctg cgcctggttg
    17101 tcggtgtcgt acgcgagctc gatcagtccg ccgagctcgg cgggcatctt ggggtagagc
    17161 ggggtgaggt cgaagccggt ggcgttcgcc cggaggatct cctggccggc cgcgatcgcc
    17221 tcggcgaagc ggagcatggg agcccgctcc ttcttgatcg actcgaccag ctcgcggacc
    17281 tcgtcggcgc gctcctccgg aatgttgatg aagtagccgc cgcgcagctc ggggttgttg
    17341 ctggccgcga cgtgtacctg cggggactgc aggtacgact cgagcagcgg cagctgcagg
    17401 aacgcgaggt tcatggcggc ctgtaccggc gccacggtgt acggccaggc gaagaacctg
    17461 tccaccagcg gctcgatgat gaccttcgac ttcagataca acagctcgtc ggacatctgc
    17521 gtccctctct ccagcagaaa gcaaaataaa ttgaccaacc gaccggctat tgctaccgga
    17581 attcggtgcg ccgggccgga cggcgatggg aacaacggcc agagagaatc agctggaacc
    17641 tgaagccagg gagccgaaga agctgcgtcc gctccgccgc acaaagctca ccgcacgcag
    17701 agcgctctcc tgaatcagaa tgacctgagg ccgtacggtg aatcaatact cgacggctgg
    17761 cgacggtcat tgaacagccg cgccgcgcgg ccgggcggca cggcgcaccg cgtataccgc
    17821 ggaacaccgg ccgcctgctg tgcaactgcg tcggggcgcc ggttgaacgg acttcggccg
    17881 gagccttgcc gcttgccggc ggacgggtca gaccgctatg gccgcgacgg ccggccgggc
    17941 gagccgctgg tagtccgcga cggacagggc gacggacagg tccagtcggc ccgcgttgaa
    18001 atagatctcg tcgtggacca gcaggccctc gtcgacgagc aggtccagct cggtggagaa
    18061 ggcgaacggg gtgatggacc cgctgacgct gcccgcgagc cgctcggcga cctcctgggt
    18121 ggcgaaggag gcctcccggc cgccgtagcg cagggccagg gcgggcagat cgacccggcg
    18181 gtcgccgggg accacggcga gcacgtagcg acgcgagcgc ttgccggtcg ccacccggat
    18241 cacgatggac ttggcggcct gctccagcgg gtgcctgcgc agctcgctgg cttcctcggt
    18301 gcggccctcc ggttcgtgcg ggatggtccg gtacgacgcg tcacctgacg cgaggaggtc
    18361 gatcaggtgc tggaaggcgt cgcggtcctc aggcatcccg ggcctccggg ggacgcgcgg
    18421 cggatgcggg gcagtggggg cggtgggaca ccattcctcc gtaggcagat gggcgccgtc
    18481 ggggaagtcc gacggtcgtg acgctcaccc agcgggatcc gaccgcaggc cggggaggcg
    18541 ccgcacgcac ctcgtggggc gtgcggaccc ttgacaagcc gtcacccatg gcaggtgtga
    18601 cggccgcgcg ccgcaacgtt cgctcgcccc tccgcgaccg cggtgcggag gggcggggcc
    18661 tcagcgctcc gggatctccg gggcgagttc gtgcagcggc acgacgttca ggaaggcgac
    18721 gtcgccgatg cgccgggcgc tcaggcccgt caccgtcagc gactggtcct cgttcagctc
    18781 caccgccgcg ccctcgtcgg ccaacaggga gctgagtacg gcgacatcag gggtccggac
    18841 cgacacgggt aacctccggc cgcggacggc gaggcgcgcc gcgcgttgcc ccgcgaccag
    18901 ttcgccccga gcgatgatga ccagttcgtc cgccatgtcg gcgagttcca tgggcagctg
    18961 gccggagacg agcaccgtgc ggccctcggc ggccagccgg tggaacaggg tacgggccca
    19021 gcgcagaccg cgctggtcca gtccgttcag tggctcgtcg agcaccagga cgggcggatc
    19081 ggcgagcagc gcgcaggcga tgccgagccg ttgccgcatc ccgagcgaga aggtggcgac
    19141 ccggcggtgt tccgccgagg tcagcccggc gatgtccagt acgtcgtcca gccggccgag
    19201 cgggatgccg tggcgccgag ccaccccggt caggtactcc cgcgcggtgt tccccccgtg
    19261 ggggcagtag accccgctgg tgcccagcag tacgccgacc tcccgcgcgc cgggcgggcg
    19321 gtcccggaac tcccggccgc cgatcgaggc actgccggag gtcggggcgc tcagtcccag
    19381 cagaagtcgc agcgtggtgc tcttgcccgc gccgctcggg ccgaggagac cggtgacgcg
    19441 cccggccccc accgtgaagc tgagtccgtc gacagccgtg acgttcccgt agcgcttcgt
    19501 cagttccctg atctcgatca tcatcaccat cgtggagtgg accggacccg cgtctccgcg
    19561 ggccggggtg gcgatcgcgg acgcacaccg tccccgcggg gtctcacccg cggggacggt
    19621 gcagtccgcg agcggatctg attcttctcg ccgcggccga gggccgtcgg cattgctcac
    19681 ccggcatcct ccggcgagcg atcggactcc cctgtccgat cttttcggac aaaggactcc
    19741 cgctgtaagg gtgacgggca cttctgcact gtccacggac agaatttcaa gggcaccgat
    19801 gggcaatgta tcggcgcggc agagaaaatt tcggtccggg cggccgaaag ggaattgacg
    19861 gcccgcacga attgacgtgc ggaatgtctg agcaccctat ccgacgcgcc tcgggcccga
    19921 cctccgacgc cccgcggggt gcggggtgcg gggtccggtc gtccgcgacc tgaccccgca
    19981 ccccgcacgg ccttcgcgta tcagccctcc cagcccagcc aggcggacac ctcggcccag
    20041 accagcccga ggtgctcggg cttcgcgagg tcgtagtggg tgcagggcac gcccgcttcc
    20101 gacaccacgc cggtcacgtg ctccgcccac cggtcggcgg tcggaccctc ttcctcgcgg
    20161 ccgttcttgg ccacgaccag cagggcgtcg ccgtcgaacc gtccgtgcgt gtgggtgcgc
    20221 cggatccggc ggccgttgtg cagcaccctg gcgaaggtcc ggtactcctc gtcggtgacc
    20281 gcacccagtg cgccgcccgc ctccagccgg acggcgtcga ccagttggtc gatctcgtcc
    20341 tccgggtcga gctccttctc ccgcgccgcc atggcggcct cttcctcgct gtcccacggg
    20401 tactggtcga gcagcaccag cgccccgacc tcctcaccgg cggcctgcag ctggacggcg
    20461 atctcgtggg cgagtacgcc gccgtacgac cagcccagca ggtggtaagg accgctcggc
    20521 tgcaccgacc gcatctgggt gatgtagtcg gcggccatct ccgctatgga accggcgagt
    20581 tcggaggtgc cgtccaggcc ccgggcctgc aggccgtaga gcggcacgtc ctccggcacg
    20641 taccggacca gcggcatgta gcaccagctc acgccgcccg ccgggtggaa gcagaagaac
    20701 ggcggacgtt cgccctgctc gcggatcggc agcagtacat ccagcgcgtc ctgcaccgag
    20761 gacaggctca tcctcttcat cagccggccc acggtcggtg ccgcgaacag gtcgcgcacc
    20821 gccatcgcca cgccacgttc ccgcagcgcc tcgacgaggc ggaccgccag cagcgagtgg
    20881 ccgcctagag cgaagaagtc gtcgtcgacg cccacgctct ccaggccgag gacctcagcg
    20941 aaagccgcac cgatgttcgc ctcgaaggag ttcaccgagt ggtgcgcctc ctcgcgcacc
    21001 gcggcctccg gcaccggcag ggccttacgg tccagcttgc cgttcggggt cagcgggaac
    21061 tgctcgatca ccacgatcgc ggacggcacc atgtacgcgg gcagccggtc ctgggccact
    21121 cccccgaccg cctgggcgaa cccgtccagc tcttccggcg ccagtgcgcg gttgggcacc
    21181 acgtaggcca cgagccgctg gtcgccgggg acgtcctcgc gcacgagggc cacggcctgg
    21241 ccgaccgagg gatgtccggc gaccaccgcc tcgatctccc ccagttcgat acggaagccg
    21301 cgcaccttca cctggtcgtc cgcacggccc aggcactcca gctcaccgtc cgcacgccaa
    21361 cgagccaggt ccccggtccg atacagccgc tccccgaacg catacggcga cgcgacgaac
    21421 cgctccgccg tcagacccga acgacccaca tagccacggg ccaactgagc ccccgccaaa
    21481 tacagttcgc ccgtcacacc gaccggagcc ggacgcatcg aacgatccag cacatacgcc
    21541 cgcgtattgg cgaacggccg acccaccgac accacatccg aagcgacctc cgccgacgtg
    21601 gcccacaccg tcgcctcggt cggaccgtac aggttcaccg cccgcacacc caggtccgtg
    21661 aaccgctgcg ccaactcacg cggcagcgcc tcaccaccca ccagcgcccg caccccggcc
    21721 ggccagccct cctcctccag cagcgcccgc cacaacgacg gcaccgcctg gagcacgctc
    21781 gcgcccgatg tgaggaccag ccgcgtcagc gcggacggat cccgcacctc ctcacgcgac
    21841 gccaacacga ccgacgcacc cgacaccaac ggcaggaaca actccaacgc ggcgatgtcg
    21901 aacgacaccg tggtcaccgc caccagccga tccccggccg cgacacccac ccgctcacca
    21961 gcagcgaaca aatggttcac caacgcaccg tgcgggacca ccacaccctt gggacgaccc
    22021 gtcgaacccg acgtataaat cacatacgcc gcattgcgcg actccagctc cacaccccca
    22081 cacaccggca cgtccgccac gtccgacaga accgccagct ccgccaccac cgacggatca
    22141 tcgaccacaa ccaccggcac acccgccggc acgacctccg caaccgccgt gtgcgacagg
    22201 accagcggga cacccgcatc ggcgagaaca taagcgatcc gctccgccgg atactccggg
    22261 tccaccggca gatacgcccc gcccgccttc atcaccgcca acagcgcaac caccagatcg
    22321 accccacggt ccatcaccac acccacgacc gactccggcc cgacaccacg cccacgcagc
    22381 aaccgcgcca gccggctcac ccgcgcatcc agctcggcgt agccgagttc gacgtccccc
    22441 tgcaccagcg cgatcgcgtc cggtgtccgg gcggcctgcg cctcgaacag ctcgacgacc
    22501 gtcgcgtcct gcaccggggc gccggtttcg ttccattcgg tgaggacacg gcgtcgctcg
    22561 tgcgcgccga gcacgtccac ctcgctgagc cgaacgtcgg ggttcgcggc cagcgaggcc
    22621 agcaaccgga cccaccgttc ggccatgcgc acgctggact cgacgtcgaa caggtcggcc
    22681 gacgccgtga gccctccgtg cagaccggcc ggcgtgccgt ccgtgtcgtg cacctcgacc
    22741 atgttgaagt ccaggtcgac cttgacggac gaggagcggg tgaccagcac gccgccgtcg
    22801 acggactctt cgaaggagtc gccggtggtc caggatgagg gcccgtccgg cttcgtcccc
    22861 acggcgttct ccagcaggaa catcacctgg aagagcgggt gacgggccat cgagcgggcc
    22921 ggtgacagct cctcgaccag tttctcgaac ggcacgtccg tgtgggacag ggaccccagc
    22981 gcggcttccc tgacccgcgc gagcacctcg cggaaggtcg ggtcgtccga gaggtcggta
    23041 cgcaccacga aggtgttgac gaagtagccg atcaagtggt gcatcgcctc gtccgtacgg
    23101 cccgcggcag ccgacccgat cggaatgtcg gtgcccgctc ccaggcggtt caggagcacg
    23161 gccagggcac cgtgcatgac catgaacatg gtgacgccct cggcccgcgc catctcggcg
    23221 agccgcgcgt gcacgtccgc agaggtctcc aggctcgtct ggtggccccg gtaactggcc
    23281 accgccggac gcgaacggtc gctcggcagc tcgagttcct ccgggatacc ggccagttct
    23341 tcccgccaga aggcgacctg ctcggccagc acgctgtccg ggtcggcgga gtcgccgagc
    23401 acctcgcgct gccagagcgc gtagtccgcg tactggaccg gcagcggcgc ccagtcgggc
    23461 gctcgaccct cggcacgtgc catgtaggcg gtcttcaggt cgttgaccat cggcccccac
    23521 gaccaaccgt cggcggtgat gtggtgcacc acgaccgcga gcacgctctc ctccgggccg
    23581 acccggatca gcgacgccct caacgggatc tcggcggcgg acaggtcgaa cgcgtaccgc
    23641 tcggcctcgg ccaccgtgcc ggccaggtcc tcctgctcca cgtcgatcac gtgcagcgtc
    23701 cagtccagct cctcgaggtc gaggatcagc tggtagggct cgccgtcggc gacccggtac
    23761 acggtgcgca gcgactcgtg gcgcccgatg acgtcacgga acgcggcgtt caggagctcg
    23821 gtgtccacct cgccccgcat cggcgagctg acggggatgt tgtaggtgct gctcggcccc
    23881 tccatctggt tgatgatcca caggcggcgc tgtccgtagg agagcggaag gcgctcgggc
    23941 cgggtgcccc gcacgagagc tgcccgggcg gccttggctc ccacgaggcg cgtggcaagt
    24001 ccggcgacgg tcggctcctc gaagagcgta cggatgtcgg tctcgatgcc gagcagggtg
    24061 cggatccggc tgaccaggcg cacggccatc agcgagtgcc cgcccagggt gaagaagtcg
    24121 tcgtccacgc cgacgctctg caggccgagg acatcggcga aggccaggca gagcagctct
    24181 tcctggagcg tcgacggccg gcggccggtg ctggccgagg ttcccgcgta gtccggtgcg
    24241 ggcagggcct tgcggtcgag cttgccgttg ccggtgaggg gcagcgcgtc caggacgacc
    24301 acggccgcgg gcaccatgtg ttcgggcagc cgccgagcgg tgaactcgcg gaccgcggac
    24361 gggagtccgt cgaggtcgcc gtcctcgtcc atcggcacca cgtacgcgat caggcgtaca
    24421 tcgccgggca cgtcctcgcg ggccaccacc gctgcctgcg ccaccagcgg gtgcgcggcg
    24481 ataccggcct gcacctcgcc cagttcgacg cggtagccgc ggatcttgac ctggtcgtcg
    24541 gcgcggccct ggaagaccac tcggccgtcc tcggtccagc aggcccggtc acccgtccga
    24601 tacatccgca ggccgggctc gaacgggttc gcgacgaacc gctcggccgt cagcgcggtc
    24661 cgcttgacat aaccccgcgc cagctgaaca cccgccacat acaactcacc cacaacaccc
    24721 acaggaaccg gccgcagcga agcatccaac acgtagaacc gggtgttcgc caccggagca
    24781 cccaccggca ccagcccggc atccgcgtcg gaaacctcca gtcgggtcgt cgccacaccg
    24841 atcgtggtct cggtcggccc gtagtggttg aacaccaccc cgtcaccgcc gtgctcgacc
    24901 agctcccgca ccaacgccgg agcagccgcc tcaccaccca gaaccagcga acgccccggc
    24961 aggacaccct ccacgccggt gaccgaagcc agcgccgcca ggtgcgaggg aaccgccttc
    25021 aggaaatcga tcccgtgctc gaccagatac gaggacaccg ccaccggatc ggtaaccgca
    25081 ccctcctcca ggacgtgcaa ctcaccaccc gtggtcagac tcgcgaacac caccgtgttc
    25141 cccaggtccg tcgcctgcgc ctgaagcagc gcataccgg
//
