LOCUS       NZ_BMVL01000013        26245 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence13, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000013
VERSION     NZ_BMVL01000013.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 234149)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 45625
            Orig. end                         :: 71870
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26245
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..26245
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26245
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16245](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16245)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    434..448
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            2220..2636
                     /locus_tag="IE257_RS38605"
                     /old_locus_tag="GCM10010343_58670"
     CDS             2220..2636
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS38605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_58670"
                     /product="hypothetical protein"
                     /protein_id="WP_229920714.1"
                     /transl_table=11
                     /translation="MATLGIHKDFLLEFAKLEKPVQKRVHEVFDKFREHRHAGLHLEKL
                     ENPRDSRIRTIRISKFMRGVLLAPDSGDSFLLLKVMAHDDAIAWALSHRATVNSATQGI
                     DCATTSPWSKQPPTCTTPRPRRKAGSSPMSRTRN"
     gene            2552..4357
                     /locus_tag="IE257_RS28605"
                     /old_locus_tag="GCM10010343_58680"
     CDS             2552..4357
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012789.5"
                     /locus_tag="IE257_RS28605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58680"
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="WP_229920715.1"
                     /transl_table=11
                     /translation="MEQATADVHHAPTEAESRLFTDVADKELTRLGIDPDLLPLVRNLS
                     TEAHLDALRKILPEQQYDVLAGLAAGLTPEDVWRESVAVHAERTAATEARQTPAEDELA
                     ASMARSQGRIALLSGPEELLDVLSRPFDAWRIFLHPSQRRIAYHPSYNGPARVTGGPGT
                     GKTVVALHRALHLARQLPDDAPDESVLLTTYTRNLAADLRHGLELLIPDQALRAKIRVV
                     NIDALANQLVREDRGGPLTMLTSQKEINSRWNALARRLGLDYSDVFLDQEWRQVVLAQD
                     LRSPEAYLKASRSGRGTALSPLRRAQVWRAVEGFTRDLRQAGEWTFLQVCAEAARLLEP
                     RTDRPFRHVVIDEAQDLHPAQWRLLRAAVAPGPDDLFIAGDTHQRIYGNKVSLRSLGVN
                     VSGRSHRLRINYRTTHEILQWSASLLSGQSLDDMDGGTDSLTGYRSVLNGGNPELRASA
                     DKAEEIADLTSRVAQWVNDGVEPGEIGVAVRYMQLGKEIAQALERAELPVRLLGTAQAS
                     GDGTGVCIGTMHRMKGLEFRFVAVAGVSDSVVPLASTLTPAEVDAQQHREDLLGELSLL
                     FVACTRAREVLRVSWHGAPSPFLAA"
     gene            complement(4387..5976)
                     /locus_tag="IE257_RS28610"
                     /old_locus_tag="GCM10010343_58690"
     CDS             complement(4387..5976)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (110-483). E-value:
                     6.1e-22. Score: 70.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS28610_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044571.1"
                     /locus_tag="IE257_RS28610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58690"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_189972772.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-30, bitscore: 99.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSAALRAAGGLVVGALVAGVVTAAPATARDARPAHVSAVDQGT
                     RIAAERAAAAGIDWRDCPTDTGLTAPIRCGRVTVPLDYAQPDGRAITLTVDRIANTGGP
                     AERQGALLHNPGGPGVSGLLFPTQVTNGNPIWARTARAYDFVGFDPRGVGHSGLFSCQD
                     PREFADTPKPDPLPHSEADKTAQRKLTRSYAEGCRVRGGELMPFLTTENTARDLEVIRA
                     ALGEKQLNYVGVSYGGYLGAVYATLFPRHVRRMIADSSIDPSRAKLGYRANLEQNLGFQ
                     RRWQDWTAWVARHDATYHLGGTAAAVQAGWEELHAEVKAHPLGGTVGPAELTTLFQNAL
                     YYDMVWAPLASIWSSHRVGDDTLLIAAATQSTNAVAAENANAVYTAVGCNDNAWPTDWK
                     TWDRDATRLHRRAPFMTWANTWKNLPCATWPIRPNTPVDVRSGSGLPPVLIVHSTRDAA
                     APYSGAVELHKRLEGSRLITDSGAGSHGVTDLVNACVNQRVDAYLLTGRLDSRNVVCAL
                     RAQEPTAVSTDR"
     aSDomain        complement(4528..5646)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS28610_Abhydrolase_1.1"
                     /evalue="6.10E-22"
                     /label="IE257_RS28610_Abhydrolase_1.1"
                     /locus_tag="IE257_RS28610"
                     /protein_end="483"
                     /protein_start="110"
                     /score="70.3"
                     /tool="antismash"
                     /translation="LLHNPGGPGVSGLLFPTQVTNGNPIWARTARAYDFVGFDPRGVGH
                     SGLFSCQDPREFADTPKPDPLPHSEADKTAQRKLTRSYAEGCRVRGGELMPFLTTENTA
                     RDLEVIRAALGEKQLNYVGVSYGGYLGAVYATLFPRHVRRMIADSSIDPSRAKLGYRAN
                     LEQNLGFQRRWQDWTAWVARHDATYHLGGTAAAVQAGWEELHAEVKAHPLGGTVGPAEL
                     TTLFQNALYYDMVWAPLASIWSSHRVGDDTLLIAAATQSTNAVAAENANAVYTAVGCND
                     NAWPTDWKTWDRDATRLHRRAPFMTWANTWKNLPCATWPIRPNTPVDVRSGSGLPPVLI
                     VHSTRDAAAPYSGAVELHKRLEGSRLITDSGAG"
     gene            complement(6038..6229)
                     /locus_tag="IE257_RS28615"
                     /old_locus_tag="GCM10010343_58700"
     CDS             complement(6038..6229)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS28615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_58700"
                     /product="hypothetical protein"
                     /protein_id="WP_189972773.1"
                     /transl_table=11
                     /translation="MTKSRIQMKARGEGLMWAAAAACLLAAVVAPLFGDSLTAIVIPCA
                     GAMSIVGGIAWLRSNQAS"
     gene            complement(6269..7054)
                     /locus_tag="IE257_RS28620"
                     /old_locus_tag="GCM10010343_58710"
     CDS             complement(6269..7054)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS28620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_58710"
                     /product="ABC transporter permease"
                     /protein_id="WP_189972774.1"
                     /transl_table=11
                     /translation="MKIQLGSELTKITSTRLWWFLLLAMVALTTGFGTFLVYAALHAPA
                     SPLRLDSPGKIVLLYNLPVAIAYVFPLAFGVVLVTQEYNSRTIVHTLLGEPRKHLVYGA
                     KLLTGLGVAFVYGVVSVGLSAAVTAVMLSAQGADPHLADSQVISALLGSLAVLTLWGPI
                     GVAIGALVRNQVVAIVGILLVTRFIEPMVRMGAARVGYAQLGAYLPGGAGDTASGGTVI
                     DAAAGMSPPSPLLGFLVLGAYTVILAALGQIRFTRYEAS"
     gene            complement(7051..7809)
                     /locus_tag="IE257_RS28625"
                     /old_locus_tag="GCM10010343_58720"
     CDS             complement(7051..7809)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980797.1"
                     /locus_tag="IE257_RS28625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58720"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_229920716.1"
                     /transl_table=11
                     /translation="MKQDGNAPEDPVISVRELTRDFGGVRAVDSLSFDVHKGRITGFLG
                     PNGAGKTTTLRMLLGLTRPTTGHAHVFGRPYGSHRRPARRIGAALEGTAFVAGRSGRDH
                     LRCYSGPAGCPRRRVDELLELVGLAEAARRPVSGYSTGMKQRLSLATALLGEPDLLVLD
                     EPANGLDPEGILWLRHFLREFVEQGRSVLLSSHLLREMEQTVDDVLLLHRGRLLYTGSL
                     DQLLQRAGGERRDLESAFMALTGADNGARL"
     gene            complement(7854..10001)
                     /locus_tag="IE257_RS28630"
                     /old_locus_tag="GCM10010343_58730"
     CDS             complement(7854..10001)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="IE257_RS28630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58730"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_209468407.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.2e-31, bitscore:
                     101.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRRVKEVHQFAPAECALCCIAMILSAHGSRNSVTRLRREYETG
                     RDGLTIKETADILRGHGMEVRTFRASTGSLRKLAFPLIAYWNDSHLVVLEKLTERRATV
                     VDPSGGRRTHPVEEFEKHYSGLVMEATPTDAYTPVRHHEPSVWWEFLRAMRGAKWPLIH
                     ASLMSLLLYVFTVLMPMAIEHVINHFARYFTELSVPVVGALLLLPMAGYFAVSMLRSAC
                     LASVIRGLGELMMGRTFRTLLGLPYKYFANRSQGELMFRLSSIASVRDMLSSQVSAVLL
                     DVGSLVVVFGYIFIKSVPLGLLAVAVFLCMVTVAAVSYRPIRKVTTFEINETTESSSLQ
                     MEALSSIETLKVSGMTDSFFANWQRVYAGAMDRTRRRIVLQGAASSGHAVFQVFGPLLV
                     LAAGLWLVWRGRLDLGTAVAVQAMTATSLGTVTSLSTAFSQFVIANAQVTRVADILHQP
                     PVKPVFGEQEVDIEGAVSLRGVGFSYPGARTPALRDVTFDVRAGQSVAVVGSSGSGKST
                     LGKLLMGLYPVGSGGIDYDGVSIGDIGADSFYRRVAYVPQEIVLSNRTIAENIAFGVPD
                     ADPEAVQRAARQAQIHQDVEAMPLGYATQIREMGGSLSGGQRQRVALARALIRQPRVLV
                     LDEATSALDTVTESRIAEALAGLKCTRIIIAHRLSTIMNADLIVVLQDGRVVQTGRHHE
                     LVALSGPYRDLVHSQVSVQPV"
     gene            complement(10001..12811)
                     /gene="lanM"
                     /locus_tag="IE257_RS28635"
                     /old_locus_tag="GCM10010343_58740"
     CDS             complement(10001..12811)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="IE257_RS28635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58740"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_189972776.1"
                     /sec_met_domain="DUF4135 (E-value: 6e-60, bitscore: 196.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-17, bitscore:
                     57.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDVLQQLLERCVEDRSGEFGGFYRPFLTECARGIRAWDGPGET
                     GRSCFVDLPQVAGTLLRAVMDAYCRTGVRTLISAFRSRESDPVCAAMAYDEFHTWLSGV
                     EGRQRLLGLYPELDRLLRLTAERHLTHAQQVLDAAWQDRAELGAAYGTDGPIISLVPGL
                     GDSHRGGRTVSSLRWQNGVTVIHKPQQESAQPLLEAVRDLADRDGAFFGPLVPRAIVRP
                     AYLWQECVRHGDVDETLGAAGYFRRFGRAAALLTMMGATDLHHENVLATPGGPVVIDTE
                     TLVSLPGHHGTGGAGALGRETEASVLNTMLFSTRFSGAALDVDMSAVGCIRPADSRRLR
                     THRVVDAGTDRIRFDQVAAGAPHGTNMATVAGEPLDPRLWSDQITAGFHEARERLRTHR
                     EAIEDTVERHRGWSVRQVLRPTYVYARFLDASTHPAYLSSTATRTDLLSKMPQRHRGVE
                     GVEAGEALRHAEAAQLVDLDIPFFDVPCDARALRGNGGEPVTTASHRTADVGSTPTEAV
                     QRAVRDFFERPAVRDLTYIGYALGSSVDDVWEERRTPVHGSCCPGLADASGWHAVLAGL
                     VVSQDEQPTWLMPKLDGDGLRLGSVNTPLHEGGGLMLYLAEAARVHGAPVIGADPGAVY
                     AAAMPRELPETTAPTDFSPFTGALSSVVTGLELVRRGVDPSRIPLPDLSVGDLDVRGLT
                     VKDFDYLNGFGGYLLYRAEYADEAGLLATGPDTGLLLDRLVELDGPPDTHQGPLGLAHG
                     RFGRIAAMSALVLRGADPSGRATEHLAAFASSYLRHRWTDEALRDARSTGGWCKGHAGA
                     AFAAAKLLRSVGCSAEQTREAIAPEVEHIITGDLSPDISFCHGVAGRLAMLCWLADHLG
                     WPQLRSEAVALSERFLDRYGQGGWTFGIGSVTDLPSFLYGRSGWHYTQLMLRDESVRLP
                     LCLGGR"
     gene            complement(12904..13107)
                     /locus_tag="IE257_RS28640"
                     /old_locus_tag="GCM10010343_58750"
     CDS             complement(12904..13107)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS28640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_58750"
                     /product="hypothetical protein"
                     /protein_id="WP_189972777.1"
                     /transl_table=11
                     /translation="MSNIVKDATTGFVSEEELVQLAEEPSELAAGAAASGILCGAGITT
                     AITTFSAAMQGGCPTSGCTGRC"
     CDS_motif       complement(12937..13107)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSNIVKDATTGFVSEEELVQLAEEPSELAAGAAASGILCGAGITTAITTFSAAMQGG"
                     /locus_tag="IE257_RS28640_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12904..12936)
                     /prepeptide="core"
                     /locus_tag="IE257_RS28640_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.50"
                     /molecular_weight="930.1"
                     /monoisotopic_mass="929.4"
                     /core_sequence="CPTSGCTGRC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNIVKDATTGFVSEEELVQLAEEPSELAAGAAASGILCGA
                     GITTAITTFSAAMQGG"
                     /leader_location="[12936:13107](-)"
     gene            complement(13243..16245)
                     /locus_tag="IE257_RS28645"
                     /old_locus_tag="GCM10010343_58760"
     CDS             complement(13243..16245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="IE257_RS28645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58760"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_189972778.1"
                     /sec_met_domain="DUF4135 (E-value: 4.2e-61, bitscore:
                     200.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.6e-43, bitscore:
                     141.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEVLRTYLPELPAGEMWDRLHRKLLSEAASAEGGGVEGVHAAPP
                     DAYDAALDIEGRFHDYVAHHVRSWTDRLDRAVAASPVVSPQNSLVRDFLTGQTGATAAL
                     MLRTLLDELNRRRAAGLLVGDTPEARYRDFRVWTNSDAGHAELLRRNAGLFRAARARVH
                     AAESYLLHLVGEVEAHRDRLAAEIPGLANRPLISAIHMGEGDTHNGGKSAARIVFADNS
                     RILYKPHPIGAEIGYHAFVRWVNERLGTGLRTITAVSTGEGGFVEYVRTEEFSGDAKEY
                     FAHIGRLAGILYLLKATDIHYENVVTCVDGPVVVDTETLLTPRLSRTVTESESSAAHQA
                     ATFISESVAGIGILPMVVKSSDSDRGMDIGAIGYDPGQKIPYRTFAVHNSGRDDMFVEL
                     AEAETVAVNANLSVFGAAGLAVSVQREIIKTEFRRILEYARTHPGEVLGAIESHLGDAH
                     FRYVNIPTVFYSQLLRMVTHPTALRDPVVRSALLHRVVLRTGDAHELVDDEARQLAAWD
                     VPYFEYTARSTTLFSRSDSQVGSIAVCADAFDEPPMDAVRARITGLGPEVIDRELHMVD
                     LAFVNKLPEEGETTGFTPVRTVGSPHVDVSRQRMLDEALRIGDEFVATMVASRHEGFPA
                     TWIAPQVMTAEQSQWSPGTLGYDLYGGSPGLALVLAGLARETGDSGYAEAALRVLDPLE
                     DQLRRGALEGPKISVGGMTGLAGTVYAISTVRRLLGTGGAMTAGELAGELARRAAPDVG
                     CDFVSGMAGTLAVCLVLHRSAQDDGDRQLVEAAARSIAGTEAAILNGLRSQYGRVTPYT
                     GYAHGAMGIAPVLLEYGTLLGDPEARDLGLGILSDVLDAYDVRDGDWPRGWGGTDRSYG
                     WCHGAPGMLLGALAAVRHAPDAVPRARMERLAELTLQRGFGNNPTYCHGDLASAEIVAM
                     AEREQPGLFGGCLDEDLYPRLFTDVVERYPERADTKYAYSSSLLVGRAGFAWSILRHIA
                     PDSYPCVLNLG"
     gene            complement(16335..16559)
                     /locus_tag="IE257_RS28650"
                     /old_locus_tag="GCM10010343_58770"
     CDS             complement(16335..16559)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="IE257_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58770"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_268251443.1"
                     /sec_met_domain="mature_ha (E-value: 4.3e-12, bitscore:
                     39.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGGKRPRESKKRSSLMHNRNVDILEEINEQNLDGLSAGTIFET
                     VTYTVASWALGNNGHLCTVTVECQKNCQR"
     CDS_motif       complement(16440..16559)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAAGGKRPRESKKRSSLMHNRNVDILEEINEQNLDGLSAG"
                     /locus_tag="IE257_RS28650_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16335..16439)
                     /prepeptide="core"
                     /locus_tag="IE257_RS28650_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.90"
                     /molecular_weight="3662.1"
                     /monoisotopic_mass="3659.8"
                     /core_sequence="TIFETVTYTVASWALGNNGHLCTVTVECQKNCQR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAAGGKRPRESKKRSSLMHNRNVDILEEINEQNLDGLSAG"
                     /leader_location="[16439:16559](-)"
                     /alternative_weights="3680.1"
                     /alternative_weights="3698.1"
                     /alternative_weights="3716.2"
                     /alternative_weights="3734.2"
     misc_feature    complement(16565..16578)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            complement(16575..16877)
                     /locus_tag="IE257_RS28655"
                     /old_locus_tag="GCM10010343_58780"
     CDS             complement(16575..16877)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980832.1"
                     /locus_tag="IE257_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58780"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_189972780.1"
                     /transl_table=11
                     /translation="MDRLIAVKSTEVWVAALPRVDRLTSREREVFALLSQGVSNQALAD
                     SLYVSERTVRAHISNISEKLELDSRLQLCLASHSHNFGCRAALAKTVADDNSGAS"
     CDS             complement(16985..17203)
                     /gene="allorf_062610_062828"
                     /locus_tag="allorf_062610_062828"
                     /protein_id="allorf_062610_062828"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MHRTWPVCTVVDGPLDQRVRSFCGVDHKGGLIAAALLFGSVTLLA
                     DHQLATLGEIHVFHARRAQHRCSGGID"
     CDS_motif       complement(17087..17203)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MHRTWPVCTVVDGPLDQRVRSFCGVDHKGGLIAAALLFG"
                     /locus_tag="allorf_062610_062828_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16985..17086)
                     /prepeptide="core"
                     /locus_tag="allorf_062610_062828_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="3537.9"
                     /monoisotopic_mass="3535.9"
                     /core_sequence="SVTLLADHQLATLGEIHVFHARRAQHRCSGGID"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MHRTWPVCTVVDGPLDQRVRSFCGVDHKGGLIAAALLFG"
                     /leader_location="[17086:17203](-)"
                     /alternative_weights="3556.0"
                     /alternative_weights="3574.0"
                     /alternative_weights="3592.0"
     CDS             17267..17497
                     /gene="allorf_062892_063122"
                     /locus_tag="allorf_062892_063122"
                     /protein_id="allorf_062892_063122"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLSASFWLKNSLRPVRSSSRGSGTQGACRQTGEPQPAGCANAVTG
                     AGTARGNAGCTTVGASAGPIRSIRGSDTSRK"
     CDS_motif       17267..17404
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLSASFWLKNSLRPVRSSSRGSGTQGACRQTGEPQPAGCANAVTGA"
                     /locus_tag="allorf_062892_063122_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       17405..17497
                     /prepeptide="core"
                     /locus_tag="allorf_062892_063122_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.60"
                     /molecular_weight="2761.0"
                     /monoisotopic_mass="2759.5"
                     /core_sequence="GTARGNAGCTTVGASAGPIRSIRGSDTSRK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLSASFWLKNSLRPVRSSSRGSGTQGACRQTGEPQPAGCAN
                     AVTGA"
                     /leader_location="[17266:17404](+)"
                     /alternative_weights="2779.0"
                     /alternative_weights="2797.0"
                     /alternative_weights="2815.1"
                     /alternative_weights="2833.1"
                     /alternative_weights="2851.1"
                     /alternative_weights="2869.1"
                     /alternative_weights="2887.1"
     misc_feature    complement(17282..17295)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.27"
                     /tool="antismash"
     misc_feature    complement(17282..17296)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.87"
                     /tool="antismash"
     misc_feature    complement(17283..17296)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.84"
                     /tool="antismash"
     CDS             complement(17775..17837)
                     /gene="allorf_063400_063462"
                     /locus_tag="allorf_063400_063462"
                     /protein_id="allorf_063400_063462"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPGRSGCAGSGPPRCASRGS"
     CDS_motif       complement(17808..17837)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPGRSGCAGS"
                     /locus_tag="allorf_063400_063462_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17775..17807)
                     /prepeptide="core"
                     /locus_tag="allorf_063400_063462_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.20"
                     /molecular_weight="951.1"
                     /monoisotopic_mass="950.5"
                     /core_sequence="GPPRCASRGS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPGRSGCAGS"
                     /leader_location="[17807:17837](-)"
                     /alternative_weights="969.1"
     CDS             complement(17809..17979)
                     /gene="allorf_063434_063604"
                     /locus_tag="allorf_063434_063604"
                     /protein_id="allorf_063434_063604"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRARCSSDSWLMWAVGLHGSGPRSSQRFLRIIFARSSCVVNREGG
                     PGHARQERLCR"
     CDS_motif       complement(17920..17979)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRARCSSDSWLMWAVGLHGS"
                     /locus_tag="allorf_063434_063604_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17809..17919)
                     /prepeptide="core"
                     /locus_tag="allorf_063434_063604_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="4025.6"
                     /monoisotopic_mass="4023.1"
                     /core_sequence="GPRSSQRFLRIIFARSSCVVNREGGPGHARQERLCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRARCSSDSWLMWAVGLHGS"
                     /leader_location="[17919:17979](-)"
                     /alternative_weights="4043.6"
                     /alternative_weights="4061.6"
     gene            18141..18509
                     /locus_tag="IE257_RS28660"
                     /old_locus_tag="GCM10010343_58800"
     CDS             18141..18509
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_58800"
                     /product="hypothetical protein"
                     /protein_id="WP_189972781.1"
                     /transl_table=11
                     /translation="MHGRGSGARGGVQSVWDFADPDHAGIGTVPYARTPNLPTSVIRVQ
                     KNHIALQDGNFVLEEGQCSQNGALTRCPEKPYDPENPTDAGYCGGWHRVLVPAHQSSTF
                     TGEGGLTPYPVHPGSCGR"
     gene            complement(19461..20798)
                     /locus_tag="IE257_RS28665"
                     /old_locus_tag="GCM10010343_58830"
     CDS             complement(19461..20798)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0031167 - rRNA methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741341.1"
                     /locus_tag="IE257_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58830"
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="WP_189972782.1"
                     /transl_table=11
                     /translation="MTSVEQNEKQSLVGEEYEVEVGPVAHGGHCIARTEDGRVLFVRHT
                     LPGEKVVAKVTEGDVDSRYLRADAITVLDASKDRVEAPCPYAGPGKCGGCDWQHAKPGA
                     QRRLKGEVVTEQLKRLAGLTPEEAGWDGTVMPAEGDKLPAGQVPQWRTRVQFAIDEDGT
                     VGLRRHRSHEIEAIEHCMIAAPGVSELGIEKQDWPQMATVEAIAATGSQDRQVVLTPRP
                     GGRLPLVELDKPVSVLRVEEKDGGVHRVHGRPFVRERADGRTYRVGMGGFWQVHPQAAD
                     TLIKAVMQGLMPRKGEMALDLYCGVGIFAGALAERLGETGAVLGIESTKRAVEDARHNL
                     ADFPRVRIEQGKVEQILPKTGITECDLVVLDPPRAGAGKQTVRHITGLSARRIAYVACD
                     PAALARDLGYFKENGYKVRTLRVFDLFPMTHHVECVAILEPIAKAA"
     gene            complement(20894..22957)
                     /locus_tag="IE257_RS28670"
                     /old_locus_tag="GCM10010343_58840"
     CDS             complement(20894..22957)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848127.1"
                     /locus_tag="IE257_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58840"
                     /product="APC family permease"
                     /protein_id="WP_189972783.1"
                     /transl_table=11
                     /translation="MSKLTDVPKRILIGRALRSDRLGETLLPKRIALPVFASDPLSSVA
                     YAPGEVLLVLSIAGVSAYQYSPWIALAVVVLMFTVVASYRQNVHAYPSGGGDYEVANTN
                     LGPKAGLTVASALLVDYVLTVAVSISSGVENLGSAVHFVIEHKVLSATVMILLLTLMNL
                     RGVKESGKLFAIPTYVFVAAVFVMIGWGAWKGIVLGETLTAPTADLEIKPEQQGLAGFA
                     MVFLLLRAFSSGCAALTGVEAISNGVPAFRKPKSKNAASTLAYMGGLAVTMFCGIIGLA
                     MASDVRMAENPAEDLLANGVPVGPEYIQNPVISQVAEAVFGDGSFLFILLAAATALVLF
                     LAANTAYNGFPLLGSILAQDRYLPRQLHTRGDRLAFSNGIVLLAGAAILLVWVYDADST
                     KLIQLYIVGVFVSFTLSQIGMVRHWNRHLKTEREVAARRRMHRSRAINAFGAFFTGMVL
                     VIVLATKFTHGAWVALLGMLIFYGTMSAIRKHYDRVSAEIAAAEGPSDDSVRPSRVHSI
                     VLVSKVHKPTLRALAFAKLTRSDTLEALSISVDPAETKALREEWDRRGINVPLKILDSP
                     YREITRPVVEYVKGLRSENPRDAVSVYIPEYVVGRWYEHLLHNQSALRLKGRLLFTPGV
                     MVTSVPYQLESSELAKRRAKKRQDWNAPGAVRRGPVDTPRPPRPPKEPTPKG"
     gene            23178..23846
                     /locus_tag="IE257_RS28675"
                     /old_locus_tag="GCM10010343_58850"
     CDS             23178..23846
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982513.1"
                     /locus_tag="IE257_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58850"
                     /product="TrkA family potassium uptake protein"
                     /protein_id="WP_189972891.1"
                     /transl_table=11
                     /translation="MHIVIMGCGRVGSALAQTLEQQGHTVAVVDQDPTAFRRLGAGFGG
                     RRVTGVGFDQDTLREAGIEDAGAFAAVSSGDNSNIIAARVAREMFGVENVAARIYDPKR
                     AEVYQRLGIPTVATVRWTADQMLRRLLPSGAEPLWRDPSGGVQLAEVHTSSAWIGHKVS
                     QLQEETGVRVAFLTRLGEAMLPTSATVLQEGDLVHVMMRTDEIDKVEAAFAEGPEEAHA
                     "
     gene            23843..24505
                     /locus_tag="IE257_RS28680"
                     /old_locus_tag="GCM10010343_58860"
     CDS             23843..24505
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432166.1"
                     /locus_tag="IE257_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58860"
                     /product="TrkA family potassium uptake protein"
                     /protein_id="WP_189972784.1"
                     /transl_table=11
                     /translation="MRVAIAGAGAVGRSIAGELLENGHEVLLVDKAPTAISVERVPQAE
                     WLLADACEITSLDEAALQRCNVVIAATGDDKVNLVVSLLAKTEYGVPRVVARVNNPKNE
                     WLFNESWGVDVAVSTPRLMSALVEEAVSVGDLVRLLRFSHGDANLVELTLPADSSVAGT
                     QIGDISWPEDTSLVTIIRGNRVLTPHGEETLEPGDELLFVAAQAREEQLEILLQARR"
     gene            complement(25033..25773)
                     /locus_tag="IE257_RS28685"
                     /old_locus_tag="GCM10010343_58870"
     CDS             complement(25033..25773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888428.1"
                     /locus_tag="IE257_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58870"
                     /product="DUF3159 domain-containing protein"
                     /protein_id="WP_189972785.1"
                     /transl_table=11
                     /translation="MTSLDKPTTPEPAGPRHAAAPSEDQKAVTQAALFDAFGGIRGTVE
                     TMLPGLLFVMIYTINKDVKWSAIAAGAVAILLVIVRLLRKDTVKHAFSGVFGVGVGVAF
                     ALFTGSAKGFYLPGMIYGVGLGVAFTVSALVGFPLLGVILGPVFKENLSWRTRNPGRKK
                     AYVKASLAWGLIFLAKYAILFPLYWWGDATQLGWVLIALKLPPMVLAVYFTWVFLAKAP
                     PPIDVIAEWEAKEAAEAAAKGPKA"
     gene            complement(25777..26196)
                     /locus_tag="IE257_RS28690"
                     /old_locus_tag="GCM10010343_58880"
     CDS             complement(25777..26196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267057.1"
                     /locus_tag="IE257_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_58880"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_078626234.1"
                     /transl_table=11
                     /translation="MSAEPRPEKPAKPARPAGRFRRMIERLSTSQEELHSAELQEDAEA
                     AGCTRICDCHDRQIVKVTGTLRTVTLRPRAGVPALEAELFDGSAALDVVWLGRRSIVGI
                     EPGRRMIASGRISMTHGRRVLFNPKYELRPLGQEH"
ORIGIN
        1 gcctcgtcag cgccggtctg cgatgcggcc gaccccgacg gggtctcctc cggcagctcc
       61 ttgcccacca ggacggccag gtctgtgctg ctcagccggt gtgccttcga ggcacgaccg
      121 ttctcgtcga agggcacgcc ctcggcctcc aggatgacct tggggtcccc ggaatgccgg
      181 tcgtcggtcc accggaaccc gcccgcgatc cggccgtcgg cggtcagcac gcggtacgcg
      241 cagtgcagtc ccgtcctggc agccacgtgg ttgccgaccg cgatggcgct ggtaccgatg
      301 agggcggcaa gctcaccgta cgacgtccag gtcccggccg gtacggccag gaggatctcc
      361 cgcaactccc gccagcccga ccactcgtcg tccgactgca cgacttcgtc cagaggcccg
      421 ggccacaggc ccacgacccg gtcggccagt tcctcggccc tggcgaggat ctccttgcgg
      481 ccccagcgct cctgcgcggc gatctcctgg ttcatccgca gcgcactgga gtcgagcagc
      541 tcctgcttgc ggtggaaggg gtggttggag agtcgtgcgt tctcacccga gagagtgagg
      601 ttgccgaggg tgtgcacgag caggttgtgg atctcctggg ggctctcgcc gtccgtggct
      661 tcctcggcca gcaggtcgaa ccactgctgg gccgggctct ggggcaggac gtgttcgacg
      721 gtgagcggcg ccttgtcgta gtcgactggc tcgctcgatc cgtagctctc ctccagccgg
      781 cgcaggatct ggaagcgctg gttgctgcgt ccggtcttgt agaagggacg ggtgcggacg
      841 gcgtcacgaa cggcgtcgtc gcccggccac acacgggcgc ccgtgcgggg gcgcgaaagg
      901 aaccggtgta ccgcctcgga cggagagttt tccttgtcca gttccttcgg gagttccatg
      961 aacacccggt tgctgcccgt cgtggacagg cccgcgaaga ggcgccgcac catgtagctc
     1021 tccgcgaacg cgagcgcctc agccgcctcc caggccgtgg tcctgccctc gtccaggagg
     1081 tccaggaggt gcagggccag cgggtagtgg gtctggccgc cccagcgcga caggcgttcc
     1141 aataccgccc gcagcccggg atcgccttcc ctctcgggct ccaggatccg catgaggcgg
     1201 tcggcgcgca gggcgaaccg ggcgatctcg gcttccagcg ccgcctcgtc cccgctcagc
     1261 ggctccaggc gcttcttctg gtcccggtag atctcgctct gccgggcgcg gctgttccct
     1321 ccgacgacga ggtccagcca caccagcagc tccagacggg cggggccgag cagctcctgc
     1381 atcgggagcc accgcttgcg gtagacgtcc tcgcccctgc tcggcaggca catgaacagg
     1441 tagttgcgca gaaggtcgct ctggctgagc cccacgccgg tgttgttgat ggactcgaag
     1501 atgcggtaga cgttgtcgcc ctcggcggca gtgatcgcaa cgatcgagag gcagtcgccg
     1561 aggacggact cgaccgcgtc cgcccaggcc tcaccaccgc tctccgtccc gtcggccaag
     1621 gcagcgatga agaagcggta ggcagcgccc acgtttccgg cgccgccggc cttcgggagg
     1681 ctgtcgatgc aggccgtgta cgcctcacgg tccgcctgcg tcggcagcag ccggtagctg
     1741 tcgtactttt cctggtacgt gttgaccagg atgaggtcgt tgatacgggc ggcctttttc
     1801 accgagcccc gagcacggtg gtggtcccgc agagccgtga acgcgagcat caaggtggtc
     1861 atccgctgct ggccatcgac gacgagccag cgctgcatcc cgcccgcggc gacgcgctcg
     1921 ggcgccagca cgaccgaacc gaggaagtga cccgagccgg gccgcccttc ctgccggtcc
     1981 tcgaccagct cctgcacgtc gccccacagc tgctgcagct cgtcgcgctg ccagctgtag
     2041 gtgcgctggt agagcggtac ctggaactgc tgctccccct ggaccagctt gctgaacgtg
     2101 gtctcctgag cgtgcacgcc cgtcctcttc ccaaacccta gacgccgagc cgccattgtc
     2161 gccccatacc gtacggtgat cagtcgaaac gtcggcacac gcacgccccg ggggcacaca
     2221 tggcgacact ggggatccac aaggacttcc tcctggagtt cgccaagctg gagaagcccg
     2281 ttcagaagcg ggtccacgag gtcttcgaca agttccgcga gcaccgccat gccgggcttc
     2341 acctggaaaa actggagaac ccccgtgact cccggatccg caccatccgc atcagcaagt
     2401 tcatgcgcgg cgtccttctc gcaccggact ccggagacag ttttctcctc ctgaaggtca
     2461 tggcgcacga cgacgccatc gcctgggcac tgagtcatcg ggcgacagtg aactctgcga
     2521 cccagggcat cgactgcgcg acgacatcgc cttggagcaa gcaaccgccg acgtgcacca
     2581 cgccccgacc gaggcggaaa gccggctctt caccgatgtc gcggacaagg aactgacccg
     2641 cctcggcatc gatcccgatc tgctccccct cgtacggaac ctcagcaccg aggctcatct
     2701 cgacgcgctc cgcaagatcc ttcccgagca gcagtacgac gtgctcgccg gcctggccgc
     2761 ggggctgacc ccggaggacg tctggcgcga gtccgtggcc gtgcacgccg agcgcaccgc
     2821 cgccaccgag gcgcggcaga ccccggccga ggacgaactc gccgcctcca tggcccgctc
     2881 gcagggacgc atcgccctgc tctccgggcc cgaggagctg ctggacgtcc tgtcccgacc
     2941 gttcgacgcg tggcggatct tcctgcaccc cagtcagcgg cgcatcgcgt accacccctc
     3001 ctacaacggg cctgcccgag tgacgggggg ccccggcacc ggcaaaaccg tggtcgccct
     3061 ccaccgcgct ctgcatctgg cgcggcagtt gccggatgac gcacccgacg aatcggtgct
     3121 gctcacgacc tacacccgga acctggccgc cgacctgcgc cacggactcg aactgctcat
     3181 cccggaccag gcactgcgcg cgaagatccg tgtcgtcaac atcgacgccc tcgcgaatca
     3241 gctcgtacgt gaggaccggg gtggcccgct gaccatgctg accagccaga aggagatcaa
     3301 ctcccgctgg aacgccctcg cccgccgact cggtctcgac tacagcgacg tcttcctcga
     3361 ccaggaatgg cgacaggtcg tcctggccca ggacctacgc tcgcccgagg cctacctcaa
     3421 ggcgtcacgc agcggtcggg gcacggcgct gagcccgctg cggcgcgcac aggtctggcg
     3481 tgccgtcgag gggttcacgc gggacctacg ccaagccggg gaatggacgt tcctccaagt
     3541 ctgcgccgag gccgcccggc tgctggagcc gcgcaccgac cgcccgttcc gccacgtggt
     3601 gatcgacgaa gcccaggacc tccacccggc tcagtggcgc ctgctgcggg cagcggtcgc
     3661 ccccggaccc gacgatctgt tcattgccgg agacacacac cagcgcatct acggcaacaa
     3721 ggtgtcactg cgcagcctcg gcgtgaacgt gagcggcaga tcccaccggc tgcgtatcaa
     3781 ctaccgcacc acgcacgaga tcctgcagtg gtcggcctcc ctgctcagcg ggcagagctt
     3841 ggacgacatg gacggcggaa ccgactccct gacggggtac cgctccgtgc tgaacggcgg
     3901 gaaccccgag ctgagggcat cggccgacaa ggccgaagag atcgcggacc tcacgtcgcg
     3961 cgtcgcccag tgggtgaacg acggtgtgga accgggcgag atcggggtgg ccgttcgata
     4021 catgcaactg ggcaaggaga ttgcgcaggc gctggaacga gccgagctgc ccgttcgcct
     4081 cctcggcacc gctcaggcat ccggtgacgg caccggtgta tgcatcggga ccatgcaccg
     4141 catgaaggga ctggaattcc gcttcgtcgc tgtcgccggt gtgagcgaca gcgtcgtccc
     4201 tctggcctcg accctgacac ccgcagaagt ggatgctcag cagcaccgag aggatctact
     4261 gggcgagttg agcctccttt tcgtcgcctg cactcgcgca cgtgaagtcc tgcgggtctc
     4321 ctggcacggc gcaccgagcc cgttcctcgc agcgtgacgc agaccccggc ctgcatgtcc
     4381 ctgccttcag cggtcggtgg acaccgcggt cggttcctgc gcacgcagag cacagaccac
     4441 attccgcgaa tccaagcggc ctgtgaggag gtaggcgtcg acgcgttggt tgacacacgc
     4501 gttcaccaga tcggtgacac cgtgagagcc tgcgccgctg tccgtgatca gccgcgaacc
     4561 ttccagtcgc ttgtgcagct ccacggcgcc ggagtagggc gcggccgcgt cgcgggtgct
     4621 gtggacgatg aggacgggag gcagaccgct gccgctgcga acgtcgacgg gagtgttcgg
     4681 gcggatcggc caagtggcgc acggcaggtt cttccacgtg ttggcccagg tcatgaacgg
     4741 tgcccgccgg tggaggcggg tggcatcacg gtcccaggtc ttccaatcgg tgggccatgc
     4801 gttgtcatta cagcccacgg ccgtatacac ggcgttggca ttctctgcag cgacggcgtt
     4861 ggtggactgc gtggcggccg cgatgagaag tgtgtcgtcc ccgacacggt gcgagctcca
     4921 gatggaggcg agcggggccc agaccatgtc gtagtagagg gcgttctgga agagggtcgt
     4981 gagctcggcg ggaccgacgg tgccgccgag cgggtgtgcc ttcacctcgg cgtgcagctc
     5041 ttcccacccc gcctggacgg cggctgcggt accgccgaga tggtaggtgg cgtcgtgccg
     5101 ggccacccac gcagtccaat cctgccagcg cctctggaac cccaggttct gctcgaggtt
     5161 ggcccgatag ccgagcttgg cacgcgaggg gtcgatggag gagtcggcaa tcatccggcg
     5221 gacatggcgg gggaaaagag tcgcgtagac ggcgccgagg tagccaccgt aggagacccc
     5281 cacgtagttg agctgcttct cgcccagcgc agcgcgaatg acctcgaggt cgcgggccgt
     5341 gttctcggtc gtcaggaacg gcatcagttc gccaccccgg acgcggcacc cttcggcgta
     5401 gcttctggtg agcttgcgtt gggcggtctt gtcggcctcg ctgtgcggaa gcgggtcggg
     5461 cttgggcgtg tcggcgaact cccgcgggtc ctggcaagag aagagaccgg agtgtccaac
     5521 gccgcgaggg tcgaatccca cgaagtcgta tgcccgggcg gtccgggccc agatcgggtt
     5581 tccgttggtg acctgggtcg ggaagagcag accagagact ccgggaccac cggggttgtg
     5641 gagcagggcg ccctgccgct ccgccgggcc gccggtgttc gcgatccggt ccacggtcaa
     5701 ggtgatggct cggccatcgg gctgggcgta gtcgagcgga acggtgaccc gaccacaccg
     5761 gatcggcgcg gtcaggcctg tgtccgtggg acagtcccgc cagtcgatgc cggccgcggc
     5821 agcgcgttcg gcagcgatcc tggtcccctg gtccactgca ctgacgtgcg ccggccgggc
     5881 gtcgcgcgca gtggcgggcg cggcggtgac cactccggcc acgagcgcgc cgacgaccag
     5941 gccaccggcg gctcgaagtg ctgctgagcg tttcacagcg tggttgttcc ttcggctggg
     6001 agcgcctcac gcctcggcgg gcggccgtgc ggcggcacta cgaagcctga ttgctgcgga
     6061 gccatgcgat gccgccgacg atgctcatcg cgcctgcgca ggggatcacg atggcggtca
     6121 gactgtcacc gaacagcggt gcgacaacag cagcaagcag acatgcggcc gcagccgccc
     6181 acatcagtcc ctcaccgcgg gccttcatct ggatccggct cttggtcatg ttgttttctc
     6241 ccttgttctg gatgagctgg ccgagcgttc aggacgcttc gtagcgggtg aaacggatct
     6301 gtccgagcgc agcgaggatc acggtgtagg cgcccagcac cagaaagccc agcaggggcg
     6361 acggagggct catgcccgcc gctgcatcga tgacggttcc accgctggcc gtgtctcctg
     6421 ccccacccgg aaggtatgcg ccaagctgtg cgtacccgac acgtgccgcc cccatccgca
     6481 ccatcggctc gatgaaccgg gtgaccagga ggatgccgac gatggccacc acctggttgc
     6541 gcaccagggc accgatcgcg acgccgatcg gcccccacag cgtgaggacg gcaaggctgc
     6601 cgagaagtgc gctgatcacc tgggaatccg cgaggtgggg gtcggcgccc tgagcggaga
     6661 gcatcacggc cgtgacagcg gcggagagtc ccaccgagac gaccccgtag acgaatgcca
     6721 caccgagccc ggtcagcagc ttggccccgt acaccaggtg ctttctcggc tcaccgagca
     6781 aggtgtgcac gatcgtacgg gagttgtact cctgcgtgac gaggacgacc ccgaacgcca
     6841 acgggaagac gtaggcgatc gcgacgggca ggttgtacag aagaacgatc ttgcccgggg
     6901 agtcgagacg cagcggactg gccggggcgt ggagagcggc gtagacgagg aacgtgccga
     6961 accccgtggt caacgcaacc attgccagga gcaaaaacca ccacaacctg gtcgaggtga
     7021 tctttgtcag ctccgaaccc aactggattt tcacagccgc gctccgttgt ccgcgccggt
     7081 cagggccatg aaggcggatt cgagatcgcg gcgctcgccc ccggcacgtt gcagcagttg
     7141 gtcaaggctt ccggtgtaga ggaggcggcc acggtgcaat agcagtacgt cgtccacggt
     7201 ctgctccatc tcgcgcagga ggtggctgga gagcaggacg ctccggccct gctcgacgaa
     7261 ctcacggagg aagtgccgga gccagaggat tccttcggga tccagaccgt tggcgggctc
     7321 gtcgagaacc agcaggtccg gttcaccgag cagcgccgtg gcgagtgaca gccgctgctt
     7381 catacccgtc gagtagccgc tcaccgggcg tcgagccgcc tcggcgaggc cgaccagctc
     7441 caggagttcg tcgacgcgcc ggcgagggca tccggcgggg ccggagtagc agcgcagatg
     7501 gtcgcgtccg ctgcgtccgg ccacgaaggc cgtaccctcc agcgcggcgc cgatacggcg
     7561 ggccggacga cggtgggatc cgtacggacg cccgaagaca tgggcatggc ccgttgtggg
     7621 cctggtgagc ccgagcagca tgcgcagcgt ggtggtcttg cccgccccgt tgggtccgag
     7681 aaagccggtg atccggccct tgtggacatc gaaggaaagg ctgtccacgg ctcgcacccc
     7741 accgaagtcg cgggtcagct cccggaccga tatgacggga tcctctgggg cgtttccgtc
     7801 ctgtttcact ggtcgttctc ctgtgcgtag tgctgtgacg tacggtcgga ggctcatacg
     7861 ggctgcacgc tcacctgcga gtgcaccagg tcccgataag ggcccgacaa ggccaccagt
     7921 tcgtggtgcc ggccggtctg caccacacgt ccgtcctgaa ggacgacgat cagatccgcg
     7981 ttcatgatcg tcgaaaggcg gtgggcgatg atgatgcggg tgcacttcag gccggcgagg
     8041 gcctcggcga tccgcgactc cgtcaccgtg tccaacgcgc tggtcgcctc gtcgagtacg
     8101 agcacacggg gctgacggat caaggcgcgt gccagggcga cgcgttgacg ctggcctccg
     8161 gacaggcttc cgcccatctc ccggatctgt gtagcgtacc ccaatggcat cgcctcgacg
     8221 tcctggtgga tctgtgcctg gcgtgctgcc cgttgcacgg cttccgggtc cgcgtcaggc
     8281 acgccgaagg cgatgttctc cgcgatcgtc cggttactga ggacgatctc ctggggaacg
     8341 taggcgaccc gccggtagaa ggagtcagct ccgatgtcac cgatcgacac cccgtcgtag
     8401 tcgatgccgc cggacccgac cgggtagagc cccatgagga gcttgcccag tgtgctcttg
     8461 cccgagcccg aactgcctac gacagccacg ctctgccctg ccctgacgtc gaaagtgacg
     8521 tcgcgcagtg cgggcgtcct ggcgcccggg taggaaaagc cgacgccacg caaggagacc
     8581 gcaccttcga tgtccacttc ctgctcaccg aacaccggct tgaccggggg ctggtgaagg
     8641 atgtcggcga cccgggtcac ctgcgcgttg gcgatgacga actgggagaa ggcggtcgac
     8701 agcgaggtca ccgtgcccag gctggtggcc gtcatggctt ggaccgccac ggcggtcccg
     8761 aggtcgaggc gtcccctcca gaccagccac agtccggccg ccagcaccag cagagggccg
     8821 aagacctgga acacggcgtg cccgctggag gcggcaccct gcaggacgat ccgccgacgg
     8881 gtccggtcca tcgcaccggc atagacccgc tgccagttgg cgaagaagga gtccgtcata
     8941 ccggagacct tcagcgtctc gatcgacgac agggcctcca tctgcagtga ggatgactcg
     9001 gtggtctcgt tgatctcgaa ggtggtcacc ttgcggatcg gccggtagct cactgcggcg
     9061 acggtgacca tgcacaggaa caccgccacg gcgaggagtc ccagtggtac ggacttgatg
     9121 aagatgtacc cgaacacgac caccaggctg cccacgtcca gcagcacggc cgagacctgg
     9181 ctggagagca tgtcccgcac cgacgcgatg ctggacagcc ggaacatcag ttcgccctga
     9241 gagcggttgg cgaagtactt gtacgggagg ccgagcaggg tgcggaaggt ccggcccatc
     9301 atcagctcac ccaggccccg gatgaccgag gccagacagg ccgaccgcag catggacact
     9361 gcgaagtacc cggccatggg caataggagg agcgccccca ccactggcac cgacagctcg
     9421 gtgaagtatc gggcgaagtg gttgatgacg tgctcgatcg ccatcggcat caggacggtg
     9481 aacacgtaca gcagcagcga catcagggac gcgtggatca acggccactt cgcaccgcgc
     9541 atggcccgca ggaactccca ccacacgctg ggctcgtggt gccgtaccgg cgtgtaggcg
     9601 tcggtgggtg tcgcttccat caccaggccg gagtagtgct tctcgaactc ctcgaccggg
     9661 tgggtccgac gtcccccgga ggggtccacg acggtggcgc gccgctcggt gagcttctcc
     9721 agtaccacca ggtggctgtc gttccagtag gcgatgagcg ggaaagccag tttcctcagg
     9781 cttccggtgc tcgcacgaaa cgtgcggacc tccattccgt gaccgcgcag gatgtccgcg
     9841 gtctccttga tggtcaagcc gtcccggccg gtctcgtact cacggcgcag ccgtgtcacg
     9901 gagttgcggg agccgtgggc ggacaagatc atcgcaatgc agcacagcgc gcactcggcc
     9961 ggcgcgaact ggtggacctc cttgacccgg cggacgcgca tcagcggcct cccagacaca
    10021 agggaagccg tacactctcg tcccgcagca tgagctgcgt gtagtgccag ccagagcgcc
    10081 cgtagaggaa ggacggcagg tcggtcacgg atccgatgcc gaacgtccag cccccctgtc
    10141 cataccggtc gaggaagcgc tcgctcaggg caaccgcctc ggaccgcagc tgcggccagc
    10201 cgaggtggtc ggcgagccag cacagcatgg ccagccgccc tgcgaccccg tggcagaagc
    10261 tgatgtcggg actgaggtcg ccggtgatga tgtgctccac ctcgggcgcg atggcctcgc
    10321 gggtctgctc ggccgaacag ccgacggacc gcaggagttt cgcggcggcg aaggcggcgc
    10381 cggcgtggcc cttgcaccat ccgccggtgc tgcgggcgtc ccgcagtgcc tcgtccgtcc
    10441 accggtggcg gaggtacgac gaggcgaagg cggccaagtg ctcggtggca cggccgctgg
    10501 ggtcggcccc gcgcaggacg agcgcgctca tcgccgcgat gcgtccgaag cggccgtggg
    10561 ccaggcccag cggaccctga tgtgtgtccg gcgggccgtc cagttcgacg agacggtcga
    10621 gcagcagtcc ggtgtccggt ccggttgcca ggaggcccgc ctcgtcggcg tactcggcgc
    10681 ggtagaggag gtagccgccg aagccgttga ggtagtcgaa gtccttcacg gtcaggccac
    10741 ggacgtcgag gtccccaacg gacaggtccg gcagtgggat gcgggacggg tccacgccac
    10801 ggcggaccag ttccagtccc gtgacgacgg acgagagggc tccggtgaac ggggagaagt
    10861 ccgtgggtgc cgtcgtctca ggcagttccc gcggcatcgc cgcggcatag accgcaccgg
    10921 ggtccgcgcc gatcacgggt gcaccgtgca ccctggcggc ctcggccagg tacagcatca
    10981 gcccgccgcc ctcgtgcaac ggtgtgttga cgctgccgag gcgtaggccg tcaccgtcca
    11041 gcttgggcat cagccaggtc ggttgttcgt cctggctgac gactagtccg gcgagcaccg
    11101 cgtgccagcc gctcgcgtcg gcgaggccgg ggcaacagct gccgtggacg ggcgtgcggc
    11161 gctcctccca cacgtcgtcc accgagctgc ccagggcata gccgatgtac gtcagatcgc
    11221 gaactgccgg acgctcgaag aagtcgcgta ccgcgcgctg tacagcctcc gtgggggtgc
    11281 tgcccacgtc ggcggtgcgg tgggaggcgg tggtgaccgg ttcaccaccg ttgccgcgca
    11341 gcgcacgcgc atcgcatggc acgtcgaaga acgggatgtc gaggtccacg agttgcgccg
    11401 cctccgcgtg acgcagcgcc tcacccgcct ccaccccctc gacgccccgg tgacgctgcg
    11461 gcattttgct caggagatcc gtccgcgtcg ccgtactgct caggtacgcc gggtgtgtgg
    11521 aggcgtcaag gaagcgggcg tagacatagg tcgggcggag cacctggcgg accgaccagc
    11581 cccgatgccg ctccaccgtg tcttcgatcg cctcccggtg ggtccggagc cgttcccggg
    11641 cctcgtggaa ccctgcggtg atctggtccg accacagtcg cgggtcgagc ggctcgccgg
    11701 ccaccgtggc catgttggta ccgtgcgggg cgcctgcggc tacctgatcg aacctgatcc
    11761 ggtcggtgcc ggcgtccacc acgcggtggg tacgcagccg acgcgagtcc gccggccgga
    11821 tgcatccgac agccgacatg tctacgtcca gagcggcgcc gctgaagcgt gtcgagaaca
    11881 gcatcgtgtt gagcaccgac gcttcggtct cacggcccag ggctccggca cctcctgtgc
    11941 cgtggtgtcc gggcagggac accagcgtct cggtgtcgat gacgacgggg ccgcctggcg
    12001 tggccaggac gttctcatgg tgcaggtcgg tggcacccat catggtcagc agggcggccg
    12061 cgcggccgaa ccgcctgaag taccccgctg ctcccagggt ttcgtccacg tctccgtgcc
    12121 ggacacactc ctgccacagg tatgcggggc ggacgatggc cctgggcacg aggggaccga
    12181 agaacgcgcc gtcccggtcg gccagatcgc ggaccgcctc caggaggggc tgggcgctct
    12241 cctgctgggg cttgtggata acggtcacac cgttctgcca gcgcagcgag gacacggtcc
    12301 ggccaccccg atgggagtcc cccaggcccg ggacgaggga gatgatgggg ccgtctgtcc
    12361 cataggcggc gcccagctcc gcacgatcct gccaggcggc gtccaggacc tgctgtgcat
    12421 gcgtcaggtg gcgctccgcg gtcaggcgca gcagtcggtc cagttcgggg tagaggccca
    12481 gcagtctctg tcggccctcc acgccgctca gccatgtgtg gaattcgtcg tacgccatgg
    12541 ctgcgcaaac ggggtcgctc tcacgggaac ggaaggccga tatgagtgtg cgcacgccgg
    12601 tgcggcagta ggcgtccatg acggcacgca ggagagtgcc ggcgacctgc ggaaggtcga
    12661 cgaagcagct gcgccctgtt tcccccggcc cgtcccatgc ccggatcccc cgcgcgcact
    12721 ccgtcaggaa cggacggtag aagccgccga actccccgga ccggtcctcg acgcaccgct
    12781 ccagcaactg ctggaggaca tcatcactca actgcaccat gacactcgct gttcgctctc
    12841 tgcacgggtg ccggccccgg gacgtcccgg ggccggcatg ccaggtttcc gcctgctgag
    12901 tcctcagcag cggccggtgc agccgctggt cgggcacccg ccctgcatcg cggcgctgaa
    12961 ggtggtgatc gccgtggtga taccggcgcc acagaggatg ccggaggcgg cagcgccggc
    13021 ggcgagctcg ctcggctcct cggccagctg gaccagctcc tcctcggaga cgaagcccgt
    13081 ggtggcgtcc ttgacgatgt tgctcatgtt ctgtcctttc tcgttgtgat gcggggtact
    13141 tgacgaaggc tcccgaaggc ttcgggaacc ccgttcagga gcggccgcgg tggactggct
    13201 gccgctgttg cgatcccgcg gccgcaagca gtggtgcggg tcctacccga ggttcagcac
    13261 gcaggggtag ctgtccgggg cgatgtgccg gaggatcgac caggcgaagc cggcgcgtcc
    13321 gacgagcaga ctgctgctgt aggcgtactt ggtgtcggcc cgctctgggt aacgctcgac
    13381 gacgtcggtg aacagccgcg gatacaggtc ctcgtccagg catccgccga agagcccggg
    13441 ctgttcccgt tcggccatgg cgacaatctc cgcactggcg agatccccgt ggcagtacgt
    13501 cggattgttg ccgaagccac gctgcagtgt cagttcggcg agccgttcca ttcgggcccg
    13561 cggtaccgcg tccggcgcgt gccggacggc tgcgagggcg cccaggagca tgccgggggc
    13621 gccatggcac cagccgtagg agcggtcggt accgccccag ccgcgcggcc agtccccgtc
    13681 acgcacgtcg taggcgtcga gcacgtcgga gaggatgccg agtccgaggt cgcgcgcctc
    13741 cgggtcgccg agaagcgttc cgtactcaag gagtaccggg gctatgccca tggcgccatg
    13801 ggcatagccg gtgtagggcg tgacccggcc gtactgggac cggagcccgt tgaggatcgc
    13861 ggcctcagtg ccggcgatgg agcgtgccgc cgcttcgacg agttgccggt ccccgtcgtc
    13921 ctgagcgcta cggtggagga cgaggcacac ggcgagcgtg ccggccatac cgctcacgaa
    13981 gtcgcagccg acgtccggag ctgcccgccg ggccagttcc cctgccagct caccggcggt
    14041 catcgcgccg cctgtgccca gtagtcgccg gaccgtgctg atcgcgtaga cggtaccggc
    14101 cagaccggtc ataccgccca ccgatatctt cggcccctcc agggctccgc gccgcagctg
    14161 gtcctccaga gggtcgagga ccctcagcgc cgcttcggcg tagccgctgt ccccggtttc
    14221 cctggcgagt ccggccagga cgagagcgag acccgggctg cctccgtaca ggtcgtagcc
    14281 cagcgttccc gggctccact ggctctgttc ggcggtcatc acctgagggg cgatccatgt
    14341 ggcggggaaa ccttcgtgcc ggctcgcgac catggtggca acgaactcgt cgccgatccg
    14401 cagggcctca tcgagcatcc gctgacgaga cacgtccacg tggggggagc cgacggtacg
    14461 aaccggggtg aaaccggtgg tctccccttc ttccggcagc ttgttgacga atgcgaggtc
    14521 gaccatgtgc agctctcggt cgatcacctc cgggccgagt ccggtgatgc gtgctcggac
    14581 agcgtccatg gggggttcgt cgaatgcgtc agcgcacacc gcgatgcttc cgacctggga
    14641 atccgagcgg gagaacagcg tggtggaccg cgccgtgtac tcgaagtacg gcacgtccca
    14701 agcggcgagt tgacgggctt catcgtccac caattcgtgg gcgtctcccg tgcgcagaac
    14761 aacccggtgg agcaatgcgc tgcgcacgac ggggtctcgc agagcggtgg gatgggtgac
    14821 catccgaagg agctgcgaat agaagaccgt gggaatgttg acgtaacgga aatgagcatc
    14881 gccgaggtgt gattcgattg cgcccagcac ctcgccggga tgcgtccgcg catactcaag
    14941 aatgcgacgg aactccgtct tgattatctc tcgttgcact gataccgcaa ggccggcggc
    15001 accgaacacg gacaggttcg cgttgactgc cactgtctcg gcctcggcca gctcgacgaa
    15061 catgtcgtcg cgacccgaat tgtgcaccgc aaacgtacgg tagggaatct tttgccccgg
    15121 gtcgtagccg atggcaccga tatccattcc ccggtccgag tcgctcgact tcacgaccat
    15181 cggcaggata ccgattccgg cgaccgactc gcttatgaac gtggcggcct ggtgcgccgc
    15241 agagctctca ctttccgtga cggtacggct caggcgcggt gtcagcagcg tctcggtgtc
    15301 gacgacgact gggccgtcca cgcaggtgac cacattctcg taatgaatgt ccgtggcctt
    15361 gagtagatag agaatgcccg ccaggcgccc tatgtgggca aaatattcct ttgcgtcacc
    15421 ggaaaattcc tcagtgcgca cgtactcgac gaatccacct tcgccggtgg acaccgcggt
    15481 gatggtgcgc aaaccggtgc ccagacgttc gttcacccag cggacgaatg cgtggtagcc
    15541 gatctccgcc ccgatcgggt gcggcttgta gaggatccgg ctgttgtccg caaacacgat
    15601 ccgggcggca gactttccgc cgttgtgggt gtcgccctcg cccatgtgga tggctgagat
    15661 cagtggccgg ttggcgaggc ctggaatctc ggcagccagc cggtcacggt gggcctcgac
    15721 ctcgccgacc aggtgcagga gataggactc ggccgcatgc acacgggcac gcgccgcccg
    15781 gaagaggccg gcgttccgcc gcagcagttc ggcgtggccg gcatcactgt tggtccagac
    15841 acggaagtcc cggtaccgcg cctcaggcgt gtcgccgacc agcagaccgg cggcccggcg
    15901 acggttcagt tcatcgagga gcgtgcgcag catcagggcc gccgtggccc ccgtctggcc
    15961 agtaaggaag tctctgacca ggctgttctg gggggagacc acgggtgagg cggccaccgc
    16021 gcgatccagc cggtccgtcc agctacgcac gtggtgcgca acgtagtcat ggaaccggcc
    16081 ttcgatgtcg agcgcggcat cataggcgtc cggcggcgca gcatggacac cctccactcc
    16141 cccgccttcg gcgctcgccg cctcgctgag gagcttccgg tgcagccggt cccacatctc
    16201 accggccgga agctcgggga gataggtgcg cagaacttcc gtcaccgcac tcgctgttat
    16261 tgcactcgtc atggtaattc cggttccacg gagaaccagg tgccggactt cacagggccc
    16321 ggcacccagg tcgatcagcg ctggcagttc ttctggcact cgactgtgac ggtgcacagg
    16381 tggccgttgt tacccagcgc ccagctggcc acggtgtagg tgaccgtctc gaagatggtg
    16441 cccgcactca gaccgtcgag gttctgctcg ttgatttctt caagaatatc gacattgcgg
    16501 ttatgcatga gacttgacct cttctttgac tcccgaggac gttttccccc ggccgccact
    16561 agtgtcgatc agggtcaact agcgccacta ttgtcgtcag cgacagtctt cgccaacgca
    16621 gcacgacagc cgaagttgtg cgaatgagag gcaaggcaga gctgaagccg cgaatcaagc
    16681 tcgagcttct cggatatgtt gctgatatgg gcccgcactg tccgctcgct cacgtagagc
    16741 gagtcggcca acgcctggtt ggaaactccc tgcgagagca gagcgaacac ttcacgctct
    16801 cgggaggtga ggcggtcgac gcgcggcaga gctgccaccc acacctcagt cgactttact
    16861 gcgatcaaac gatccatctg atgcttccac tcgcaactgt cctcgcgagc cgtggccgac
    16921 gccgacaggc tcgcacgccg atgacttcag gcttcaggta acagaaggcg agtcagatac
    16981 tgcttcagtc gatgccaccc gagcagcggt gttgtgcgcg tcgcgcgtga aatacatgaa
    17041 tttcccccag agttgcaagc tggtggtcag ccagcagcgt cacgctacca aacaggagag
    17101 cggccgcgat taaaccgccc ttgtgatcta caccgcagaa tgaacgaacg cgttgatcta
    17161 atggtccgtc aacaacggta cacacaggcc atgttcggtg catcaggcga cgccgggact
    17221 actccctcgg acaagcggtc cagcgcaact cgattgatcc ggggagatgt tgtcggcctc
    17281 tttttggctg aaaaattccc tgaggcctgt gaggtcgtcc tcgagaggga gcgggaccca
    17341 aggggcctgt cggcagaccg gtgagccgca acctgcgggg tgcgcgaatg cggtgaccgg
    17401 cgccggcaca gcgcggggta acgcggggtg cacaaccgtc ggggcgtccg ccggaccgat
    17461 ccgttcgatc agagggtcgg acacgagtag gaagtagcga ggggccgact ccaagacgcc
    17521 gtcggaccct ctgggcatct gccacgctga gcccggaagc gcttcaacgc cgcccgccac
    17581 gacggccgat gaccgatggc ccaacccgtc ccagggggac cgcatgacca aaacgtgacc
    17641 aacagtgccc agtaacagac agaaacacct ggaagagggc tgacacggag ggaagttcag
    17701 aacctacgcc acgccgatag aactgcaggt caggggtggc acgggccggt tccatcgagg
    17761 gggctgccgt tcactcatga gcctcgagaa gcgcagcgag gcggtccact accggcacag
    17821 ccgctcctgc ctggcatggc ccggtcctcc ctccctgttc accacacagg agctacgagc
    17881 gaagatgatc cggaggaagc gctgcgagct gcgcggacct gacccgtgta ggcccactgc
    17941 ccacatcagc cacgagtccg acgagcacct cgcccgcaag gaatgcgtcg cgaaggactc
    18001 cgaagatcac ggcttccacg ccggcatcga gtcgcacacc gcagacgggc acgcgcgcct
    18061 cgatgtacgc atcaacggcg ccaacggcat cgtccttggc tacgatcctc agctgagcgc
    18121 ccagacagcc cgcggaatgc gtgcacggga ggggttccgg cgcccgtggc ggtgttcagt
    18181 cggtctggga cttcgccgac cccgaccacg caggcatcgg caccgtccca tacgcccgca
    18241 cgcccaacct gccgacctcc gtcatccgcg tgcagaagaa ccacatcgcg ctccaggacg
    18301 gcaacttcgt cctggaggag ggccagtgca gccagaacgg cgcgctcacc cggtgcccgg
    18361 agaagcccta cgacccggag aaccccaccg acgccgggta ctgcgggggc tggcaccgcg
    18421 tcctcgtgcc cgcccaccag tcgagcacct tcacggggga aggcggtttg accccttacc
    18481 cggttcatcc tggaagctgc ggccggtgag cggatcccgt tccagcgggg cggccaccac
    18541 ggttggctcc ccgcacagca gtggcagcaa tacctcgaga cgaacgggcc cgccctggac
    18601 cacaaggagc gccagccact cgtacgacag ggggaccggc gcgacaggtg caccgaggac
    18661 cgtccggctt cggaggtgcg ggctgaacca ccgaagcaga gacgtggcgg acgcgcgatc
    18721 gtccttgagt cccgaccccg ggaagccgag gccgccaggg ttccggtcga tgcctcgggt
    18781 caagcaatcc cgctcggccg ctacggccgc ggtcagcccg caagccttcc aggacccgaa
    18841 gggctgcccg agcacttctc gtgccgcagg aatcatgcgg cgtgatctat cggccaccgc
    18901 tgactgcccc tcgctgcgtc acctggcgcg agagccccct accccggttc gggtggagga
    18961 tgtcgtattt ccgcccgaga tatcggtcct cggtgccaca gtgggcgcag cacacccagc
    19021 acccttttcc cgaggagcag accgtggccc agagcaccac cttccgcacc agcaccaagc
    19081 aggacaccct caccaaccac gttgtggagt tcctcagccg ggcctcccgc gcactccgga
    19141 acttggccga ctcggctgac cacgcggcga agatggtgcg aaaagcggac tcggcacggc
    19201 gaagctgaac cgtcacaccc gggtaggcca gcggacgtgc tctccgcgcg agcggaggtg
    19261 agccgccccg cggaggaaca aggccggccg gcctccagcg cacagccctg gccccgccct
    19321 acggggcctg gctcgcccaa caggtcgcct gactccccat cagaacgagc gtcatttgag
    19381 cgtcacgagc gtcatttcag cgtcaagata tcgcccgtaa cgcccacaat gcacataacg
    19441 cacaccggga aacctgcagg tcaggcggcc ttcgcgatgg gttcaaggat cgcgacgcac
    19501 tccacgtggt gcgtcatcgg gaagaggtcg aagacgcgca gggtgcggac cttgtagccg
    19561 ttctccttga agtagccgag gtcccgggcc agggccgccg ggtcgcatgc cacgtacgcg
    19621 atgcggcgcg ccgagaggcc cgtgatgtgg cggaccgtct gcttgcccgc gcccgcgcgc
    19681 ggggggtcca ggacgaccag gtcgcactcc gtgatccccg tcttcgggag gatctgctcg
    19741 accttgccct gctcgatgcg gacccgcggg aagtccgcca ggttgtggcg ggcgtcctcc
    19801 accgcgcgct tcgtcgactc gatgccgagg acggccccgg tctcgcccag gcgttccgcg
    19861 agggcgcccg cgaagatgcc gacgccgcag tagaggtcga gggccatctc gcccttgcgc
    19921 ggcatcaggc cctgcatgac ggccttgatc agggtgtccg cggcctgcgg gtggacctgc
    19981 cagaagccgc ccatgcccac gcggtacgta cggccgtccg cgcgctcccg tacgaagggg
    20041 cggccgtgga cgcggtggac gccgccgtcc ttctcctcca cgcgcagcac ggagaccggc
    20101 ttgtccagct ccacgagggg gaggcggccg ccggggcggg gggtgaggac gacctggcgg
    20161 tcctgggagc cggtcgcggc gatcgcctcg acggtggcca tctggggcca gtcctgcttc
    20221 tcgatgccca gctcgctgac gcccggcgcc gcgatcatgc agtgctcgat ggcctcgatc
    20281 tcgtgcgagc ggtggcggcg caggccgacc gtgccgtcct cgtcgatggc gaactgcacg
    20341 cgggtccgcc actgcggcac ctgcccggcc ggcagcttgt cgccctcggc gggcatcacg
    20401 gtgccgtccc agccggcttc ctccggggtg aggccggcga gccgcttcag ctgctcggtg
    20461 acgacctcgc ccttgagccg gcgctgggcg ccgggcttcg cgtgctgcca gtcgcagccg
    20521 ccgcacttgc cggggccggc gtacgggcag ggggcctcca cgcggtcctt ggaggcgtcg
    20581 agcacggtga tcgcgtcggc gcgcaggtag cgggagtcga cgtcgccctc ggtgaccttg
    20641 gcgacgacct tctcaccggg cagggtgtgg cggacgaaca ggacgcggcc gtcctcggtc
    20701 ctggcgatgc agtgaccacc gtgcgcgacg gggccgacct cgacctcgta ctcctccccg
    20761 accagtgact gcttctcgtt ctgctcgacg ctcgtcatgg tggggagact ccaaaaaact
    20821 gaaccaacgg aaaacggccg gacgaccgac ccaccagttt acgtggatct cgtccggccg
    20881 ttcaccaacc ggctcagccc ttcggggtgg gctccttcgg cggccgcggc ggccgaggcg
    20941 tgtcgaccgg gccccggcgc accgcacccg gggcgttcca gtcctggcgc ttcttcgccc
    21001 gccgcttggc gagctccgag gactccagct ggtagggcac cgaggtgacc atgacaccgg
    21061 gcgtgaagag cagccggccc ttgaggcgca gcgcgctctg gttgtgcagg aggtgttcgt
    21121 accagcggcc gacgacgtac tcggggatgt agacgctgac cgcgtcgcgc gggttctcgc
    21181 tgcgcagccc cttgacgtac tcgaccaccg ggcgggtgat ctcccggtac ggcgagtcga
    21241 ggatcttgag cgggacgttg atcccgcgcc ggtcccactc ctcgcgcagc gccttggtct
    21301 cggccgggtc cacgctgatg ctgagcgcct ccagggtgtc cgagcgggtc agcttggcga
    21361 acgccagggc gcgcagcgtg ggcttgtgga ccttggagac caggacgatc gagtggaccc
    21421 gggagggccg cacgctgtcg tcgctggggc cctcggcggc ggcgatctcc gcggagacgc
    21481 ggtcgtagtg cttgcggatc gcgctcatcg tgccgtagaa gatcagcatg ccgagcaggg
    21541 ccacccatgc accgtgggtg aacttcgtgg cgaggacgat gaccagcacc atgccggtga
    21601 agaaggcgcc gaaggcgttg atcgcccggg agcggtgcat ccggcggcgg gcggcgacct
    21661 cgcgctccgt cttcaggtgg cggttccagt gccggaccat gccgatctgg ctcagcgtga
    21721 aggagacgaa cacgccgacg atgtagagct ggatcagctt ggtcgagtcc gcgtcgtaga
    21781 cccagacgag caggatggcc gcgccggcga ggagcacgat gccgttggag aaggcgagcc
    21841 ggtcgccccg ggtgtgcagc tggcgcggaa ggtagcggtc ctgcgcgagg atcgagccga
    21901 gcagcgggaa gccgttgtag gcggtgttcg ccgccaggaa gagcaccagt gcggtggccg
    21961 cggccagcag gatgaagagg aagctgccgt cgccgaagac ggcctcggcc acctgcgaga
    22021 tcaccgggtt ctggatgtac tcggggccga ccgggacgcc gttcgccagc aggtcctcgg
    22081 cggggttctc ggccatcctc acgtcgctgg ccatggccag gccgatgatc ccgcagaaca
    22141 tggtgaccgc caggccgccc atgtaggcga gggtggacgc cgcgttcttg ctcttcggct
    22201 tgcggaaggc gggtacgccg ttgctgatgg cctcgacacc ggtcagggcc gcacagccgg
    22261 aggagaaggc cctcagcagc aggaagacca tcgcgaagcc ggccagcccc tgttgctcgg
    22321 gtttgatctc gaggtcggcg gtcggcgccg tcagggtctc gccgaggacg atgcccttcc
    22381 aggcacccca gccgatcatg acgaatacgg cggcgacgaa gacataggtc gggatcgcga
    22441 agagcttgcc ggattccttc acaccgcgca ggttcatcag cgtgagcaga aggatcatga
    22501 cggtcgccga gagcaccttg tgctcgatga cgaaatgcac ggcggagccg aggttctcga
    22561 ctccggagga gatcgacacg gcaacggtca ggacgtagtc gacgagcagg gcgctcgcca
    22621 cggtcaggcc ggccttgggt ccgagattcg tgttggcgac ctcgtagtcg ccgccaccgc
    22681 tcgggtaggc gtggacgttc tgacggtagg acgccacgac ggtgaacatc agcacgacga
    22741 ccgcgagtgc gatccagggg ctgtactggt acgccgacac gcccgcgatc gacaggacca
    22801 gcaggacttc gccaggggca tatgccacgg acgacagcgg gtcggaggcg aagacgggaa
    22861 gggcgatccg cttgggaagg agtgtttctc cgaggcggtc gctgcgtagc gcccggccga
    22921 tcaggatccg tttgggcacg tcggtcagtt tggacacgca gaggatcgta agcgttcgaa
    22981 atcagactga cgaacccccc accccctgat accgcaatcc cgccgcaatt cctccccggc
    23041 ggcaccacga ctgcggcgca agaggcccca ccggtgaccg cccgtgtgta gcttgggcca
    23101 tggtctgaga ccctgttaaa ccagagcatg caatgaggct gggaaccagc gagtcgctga
    23161 cagccggaag gacggccgtg cacatcgtca tcatgggttg cggaagggtg ggctccgccc
    23221 tcgcgcaaac cctggaacag caggggcata cggtcgccgt cgtcgaccag gaccccaccg
    23281 cattccgccg gctcggcgcc ggattcggcg gccgccgcgt caccggtgtc ggcttcgacc
    23341 aggacaccct gcgggaggcg ggaatcgagg acgcgggcgc cttcgccgcc gtcagcagtg
    23401 gtgacaattc caacatcatc gccgcccgcg tggcccgtga gatgttcggc gtcgagaacg
    23461 tcgccgcccg catctacgac cccaagcgcg ccgaggtcta ccagcgtctc ggcatcccca
    23521 cggtcgccac cgtgcgctgg accgccgacc agatgctgcg ccggctgctg ccctcgggcg
    23581 ccgagccgct gtggcgcgac ccgagcggtg gcgtgcagct cgccgaggtg cacacctcct
    23641 ccgcgtggat cgggcacaag gtcagccaac tccaggagga gacgggcgtc cgcgtggcgt
    23701 tcctcacccg cctgggcgag gcgatgctgc ccacgtcggc gacggtcctg caggagggcg
    23761 acctcgtcca cgtgatgatg cgcacggacg agatcgacaa ggtcgaggcg gcattcgccg
    23821 aaggccccga ggaggcacac gcatgagggt cgcgatcgcc ggggcaggtg cggtgggtcg
    23881 ctccatcgcg ggcgaactgc tggagaacgg ccacgaggtg ctcctcgtcg acaaggcccc
    23941 gaccgccatc tcggtggagc gggtaccgca ggcagagtgg ctgctggccg acgcctgcga
    24001 gatcacctcg ctggacgagg ccgcgctcca gcgctgcaac gtggtcatcg cggccaccgg
    24061 cgacgacaag gtcaacctgg tcgtctcgct gctcgccaag accgagtacg gggtcccgcg
    24121 cgtggtggcc cgcgtcaaca acccgaagaa cgagtggctc ttcaacgagt cctggggcgt
    24181 cgacgtcgcc gtctccacgc cgcgcctgat gtcggccctg gtcgaggagg ccgtcagcgt
    24241 cggcgacctg gtgcggctgc tgcgcttcag ccacggcgac gccaacctcg tcgaactgac
    24301 cctgccggcc gactcctcgg tcgcgggcac ccagatcggc gacatcagct ggcccgagga
    24361 cacctcgctg gtcacgatca tccggggcaa ccgggtcctc accccgcacg gggaggagac
    24421 cctggagccg ggcgacgaac tgctcttcgt ggccgcccag gcccgcgagg aacagctgga
    24481 gatcctcctc caggcccgcc gctagccctt ggccctgcgg gcacgctcga cgacgaaggg
    24541 ggcgcgccct gcggggcgcg cccccttcgg gcttcccgcc gccggtctgc gtgcccctgc
    24601 gcgaccgcgc tgtacgaccg cgggctctcg ctcccgcggc tgtcccggcc cggtggcgcg
    24661 aaaaccgtgg ccgacagccc gccccggccg cccagccgcc cggcatcgac ctgcgcacgg
    24721 cacgccttgc ccggcaggcg cgcatgcagc gctactgcgc cctccgcgac ccgggcatgc
    24781 ccgcccggcg gcgcgccacc gggccgtcgg ccctgccgcg atcccggggc gcgcccggca
    24841 gccgcccgag tcgtcacgtc agcgccctgc ggaccccacc ccgcgccggg ggccgtctgt
    24901 cccgtccggc cccccctgcg cccccgcaga cgcgcgcgtt ccgccgccgg ggtcgcggca
    24961 gtgcgtacgc agtacgaaag gggcgggacc ggcctgcagg ccggtcccgc ccctttcgtc
    25021 agctgtgcgc cgtcaggcct tcggcccctt ggcggcggct tcggcggcct ccttggcctc
    25081 ccactcggcg atcacgtcga tcggcggcgg cgccttggcc aggaagaccc aggtgaagta
    25141 caccgcgagc accatcggcg gcagcttcag cgcgatgagt acccagccca gctgcgtcgc
    25201 gtcaccccac cagtacagcg ggaagaggat cgcgtacttc gcgaggaaga tcaggcccca
    25261 ggccaggctg gccttgacgt acgccttctt gcgcccgggg ttgcgggtgc gccaggacag
    25321 gttctccttg aacaccgggc cgaggatcac gcccagcaac gggaagccca ccagcgccga
    25381 gaccgtgaag gccacgccca ggccgacgcc gtagatcatg cccggcaggt agaagccctt
    25441 cgcgctgccc gtgaacaggg cgaatgccac gcccacgccc acgccgaaca ccccgctgaa
    25501 ggcgtgcttg accgtgtcct tgcgcagcag ccggacgatc accagcagga tcgcgaccgc
    25561 gcccgccgcg atggcggacc acttcacgtc cttgttgatc gtgtagatca tgacgaagag
    25621 cagcccgggc agcatcgtct ccacggtgcc ccggatgccg ccgaaggcat cgaagagcgc
    25681 tgcctgggtc acggccttct ggtcctcgga cggcgcggcc gcatgtcgcg gcccggccgg
    25741 ttccggggtg gtcggtttgt cgagtgacgt caccggtcag tgctcctgtc cgagcgggcg
    25801 gagttcgtac ttcgggttga agagcacccg acggccgtgg gtcatggaga tgcgccctga
    25861 agcaatcatg cgtcggccgg gctcgattcc cacgatcgag cgacgcccga gccagaccac
    25921 atccagtgcg gccgagccgt cgaagagctc ggcctccagg gcgggaacgc ccgcacgcgg
    25981 ccgcagggtg accgtacgca gggttccggt caccttgact atctgacggt cgtggcagtc
    26041 gcagatccgc gtacaccccg cggcttctgc gtcctcctgc agctccgccg aatgcagctc
    26101 ctcctgggag gtggacagcc gctcaatcat ccggcggaac cggcccgcag gcctggccgg
    26161 cttcgcgggc ttctcgggac gcggttcagc actcatacag gaagcgtacc ggcgtgccca
    26221 ctaccgctcg aagcggtatc ccatg
//
