LOCUS       NZ_BMVL01000010        21044 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence10, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000010
VERSION     NZ_BMVL01000010.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 312995)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 221040
            Orig. end                         :: 242084
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21044
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21044
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21044
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11044](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11044
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            663..1112
                     /locus_tag="IE257_RS25710"
                     /old_locus_tag="GCM10010343_53060"
     CDS             663..1112
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741528.1"
                     /locus_tag="IE257_RS25710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53060"
                     /product="hypothetical protein"
                     /protein_id="WP_189972287.1"
                     /transl_table=11
                     /translation="MSKKQPANAPAPAAAPPAALPGRLTAAAALTALEGLALAGLGLYM
                     LFVGIAGDPDSPQQAETGGITLLALAALPLIAARGLRLGRRWSRGPALITQLMALPVAW
                     TLYSTGGAMIAAAVALALAAVAVVALLVNPTATEALGIGPGEQAR"
     gene            complement(1153..2193)
                     /locus_tag="IE257_RS25715"
                     /old_locus_tag="GCM10010343_53070"
     CDS             complement(1153..2193)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266462.1"
                     /locus_tag="IE257_RS25715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53070"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_372453171.1"
                     /transl_table=11
                     /translation="MSGGEIPVRGGDRPRVRHEVDGGIPEQQHARPHPADADAEDGFLD
                     SAERRAGPMSENQQEQPQSPQPTEAAATAPELAPVVPAAPVLPVSHALPDPRDRSGARA
                     LFIELRAMPDGSVEKAELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSV
                     DRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLSLTTATAELSQQHG
                     RSPTVHELAERLGISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGAEDEALEG
                     VEYRESLKPLLEGLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLRD
                     KLLVEE"
     gene            complement(2190..2603)
                     /locus_tag="IE257_RS25720"
                     /old_locus_tag="GCM10010343_53080"
     CDS             complement(2190..2603)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966375.1"
                     /locus_tag="IE257_RS25720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53080"
                     /product="anti-sigma regulatory factor"
                     /protein_id="WP_030012703.1"
                     /transl_table=11
                     /translation="MSQIAGEPGTQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLIDDSLEVTVSAPTTDGRAPERDTFAWTV
                     LSALAGKVEATVEENRTVSISLYKQRGAGPGPA"
     gene            complement(2809..3069)
                     /locus_tag="IE257_RS25725"
                     /old_locus_tag="GCM10010343_53090"
     CDS             complement(2809..3069)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966374.1"
                     /locus_tag="IE257_RS25725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53090"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_189972288.1"
                     /transl_table=11
                     /translation="MSECTHVAELPRPEPVPSHDTCSECLALGSHPVQLRMCLGCGHVA
                     CCDSSPHRHATAHHKDTGHPVMRSFEPGETWRWCFVDGSIV"
     misc_feature    3220..3234
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            3282..4862
                     /locus_tag="IE257_RS25730"
                     /old_locus_tag="GCM10010343_53100"
     CDS             3282..4862
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105585.1"
                     /locus_tag="IE257_RS25730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53100"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_189972289.1"
                     /transl_table=11
                     /translation="MEVLPLVALIAGSAAVAGLARRTPVPAPLLLVAAGLLAGYVPGVP
                     AYALDPHIVLPLLLPPLLYTAAVDSSYLDLRANIRPIAMLSVGYVLFATLAVGYAAYLL
                     VPGLSVPVALVLGAVIAPPDAVAATAIARKLRLPNRITTILQGESLVNDATAITAYKVA
                     LAAAVGVSAGWAGGIAEFLLASVGGIGVGLLLMVPIHHLRTRLKEPLLQNTLSLLIPFV
                     AYAAAERVHASGVLAVVVVALYLGHRNWQVDFATRLQEEAVWKVVAFVLESVVFALIGL
                     QLPVVLGGLGEYDGMHAATYAVAVFIAVVVARFLWVFPATFVPRWLSERIRARESDTDW
                     KAPVIVGWAGMRGVVSLAIAFSVPMSVPHRNLILFLTFTTVIGTLVVQGLTLPPLIRVL
                     NLPPKDVQAETLAEAQAQSEASRAAEERLAELLEEPENSTLPPPLADRLRTVLERRRNA
                     VWERLGEVNPETGESADDIYRRLAREMIAAEREVFVTLRDQRRIDDEMLRALLRRLDLE
                     EAAAYREEG"
     gene            complement(4897..5790)
                     /locus_tag="IE257_RS25735"
                     /old_locus_tag="GCM10010343_53110"
     CDS             complement(4897..5790)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266466.1"
                     /locus_tag="IE257_RS25735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53110"
                     /product="1-aminocyclopropane-1-carboxylate
                     deaminase/D-cysteine desulfhydrase"
                     /protein_id="WP_189972290.1"
                     /sec_met_domain="PALP (E-value: 5.8e-21, bitscore: 69.3,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHSELLPRPPSPLVEAADDRFGRYGVRLLLKRDDLVHPELPGNK
                     WRKLAPNLRAALEGGHDQLVTFGGAYSNHLRATAAAGRLLGLRTVGIVRGDELAGRPLN
                     ESLARCAADGMRLHFVSRSEYRRKAEPHRLARLVDAAGAAGAYVVPEGGSNALALGGCA
                     ELGRELRGAADVVAVACGTGGTLAGLAAGLGTGQRALGVPVLAGGFLAAEIRSLQAAAF
                     GGPAGDWALAEDFHHGGYARVPAELEAFAADFGSRHGLPVERIYVAKLLWALTELTASG
                     AFAPGTTLAAVVTGRP"
     gene            complement(5819..6409)
                     /locus_tag="IE257_RS25740"
                     /old_locus_tag="GCM10010343_53120"
     CDS             complement(5819..6409)
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154135.1"
                     /locus_tag="IE257_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53120"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_189972291.1"
                     /transl_table=11
                     /translation="MAAPMSADRFINALRNEGLTVVEVGAWRTHNRNHKGPWGPVHGVM
                     IHHTVTRGTARTVELCREGHSALPGPLCHGVIAKDGRVHLVGYGRANHAGAGDSDVLAA
                     VIAEKRLPPDNETDTDGNRHFYGFECENLGDGEDPWPAVQLDAIARAAAALCRVHRWTS
                     RSVIGHREWQPGKVDPRGFTMDAMRARIGERLK"
     gene            complement(6536..7732)
                     /locus_tag="IE257_RS25745"
                     /old_locus_tag="GCM10010343_53130"
     CDS             complement(6536..7732)
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127491.1"
                     /locus_tag="IE257_RS25745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53130"
                     /product="globin domain-containing protein"
                     /protein_id="WP_189972292.1"
                     /transl_table=11
                     /translation="MLSETSTATVRATLPAVGAAIGEIAELFYTKLFAAHPALIRDLFN
                     RGNQSAGLQKQALAGSIAAFATHLLAHPDTRPDVMLNRIAHKHASLGVTREQYAVVHQH
                     LFEAIGEVLGEAVTPEVARAWDEVYWLMANALIALEERLYAEQRVVAGDVWREWTVTDR
                     VAETADCTTFRIAPADGAPAPAHRPGQYVSVQVELPDGARQIRQYSLITSPGSAVRAIT
                     VKRIHGPAAAGPAGEVSNHLHARVRTGDTLRVSAPYGDLVPADSAAPVLLASAGIGCTP
                     MLSMLEHLADTGHTAPVTVLHADRSPADHPLRSDHRALTHKLPDASARFWYEEAAEPGD
                     GEGRMDLSAVAVAPGTRAYLCGPLPFMRAVREQLIAKGLPAADIHYEVFGPDLWLASV"
     misc_feature    complement(7825..7838)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            complement(7895..8353)
                     /locus_tag="IE257_RS25750"
                     /old_locus_tag="GCM10010343_53140"
     CDS             complement(7895..8353)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031657.1"
                     /locus_tag="IE257_RS25750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53140"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_189972293.1"
                     /transl_table=11
                     /translation="MRLTRFTDLALRVLMRLAIEETDLPTTRDVAATMEVPYTHTAKVV
                     ARLQHLGLVEARRGRGGGLALTAAGRAAPVGSVVRELEGEGDVVDCEGTTPCPLRGACV
                     LRGALRRAQEAFYAALDPLTVNDLVASPTGPLLLGISSRAPTGAGSSP"
     gene            8589..9995
                     /locus_tag="IE257_RS25755"
                     /old_locus_tag="GCM10010343_53150"
     CDS             8589..9995
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061505.1"
                     /locus_tag="IE257_RS25755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53150"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_189972294.1"
                     /transl_table=11
                     /translation="MSVQAGSESEAQTPQRSLGTTAARNLATTTKSAPQMQEITSRWLL
                     KMLPWVSVQGGTYRVNRRLSYSVGNGVVEFIKTGTQVQVIPAELGELPLLRDYEDLDVL
                     GELAQRCRQVEFEAGQELTSFGSPADQVFLLAHGRIDQIGPGPYGEDAVLGSVADGAYF
                     GDESLVDEESIWEYTARAATSGTALTLSRQDFQLLADRVESLRAHVDNVRSRPDRQTNK
                     YGEAAIELSAGHQGEAVLPGTFVDYEARPREYELSIAQTVLRVHSRVADLYNHPMNQTE
                     QQLRLTVEALRERQEHEMLNNRDFGLLHNADYDQRIQPHDGAPSPDDMDQLLSMRRGSK
                     LFLAHPKAIAAFGRECNKRGIYPESVDIGGNRVPAWRGVPIFPSNKIPISDARTTSILC
                     MRTGEDEQGVIGLHQPGIPDEIEPSLSVRFMGISEQAIISYLVTAYFSAAVLVPDALGV
                     LENVEIGRWR"
     gene            10001..11044
                     /locus_tag="IE257_RS25760"
                     /old_locus_tag="GCM10010343_53160"
     CDS             10001..11044
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130750.1"
                     /locus_tag="IE257_RS25760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53160"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_372453172.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-59, bitscore:
                     195.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTIVTGEGQDATALLDRTREAVDPQLRRTVESLPGSMRRVAMYH
                     FGWEHEDGSPAAGGAGKAIRPALVLASAQALRGPGAGPADEAVRAAAAVELAHNFTLLH
                     DDIIDKDARRRGRATAWTVFGTPDAIITGDAMMALSLRLLAEDPHPAAAAASARLAACI
                     IELCAGQQADCAFEQRPDVSLDECLAMATAKTGALLGCACALGALYAGAGPDEVDAMDA
                     FGREAGLAFQLIDDLIGIWGDPGHTGKPAGADLIARKKSLPVVAALTSDTAAGKELAAL
                     YAGPMAGDDVRRAADAVDRAGGRDWAQAEAADRMGRAVQQLSRAVPDLGAAGGLLALAE
                     FVTRRTR"
     gene            11178..11780
                     /locus_tag="IE257_RS25765"
                     /old_locus_tag="GCM10010343_53170"
     CDS             11178..11780
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741540.1"
                     /locus_tag="IE257_RS25765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53170"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_189972295.1"
                     /transl_table=11
                     /translation="MALEIRQADQSDRDAVARLLDESFRTDPVSSWVFPDPEHRAAVHG
                     KFLGVFVDVALEEGRIDYATDGSAAALWLRIPAGDPEGEVVEDEVPARMRAVADPDNER
                     CELVGRLTGAVHPTAEEHEYLLMIAVAPDRQGQGLGSELMRPVLERCDREGVPAYLEAS
                     SERSKELYERLGWEFTGEVVRLPEGPLMWPMWRKPRG"
     misc_feature    complement(11804..11817)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            11889..12473
                     /locus_tag="IE257_RS25770"
                     /old_locus_tag="GCM10010343_53180"
     CDS             11889..12473
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019767199.1"
                     /locus_tag="IE257_RS25770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53180"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_189972296.1"
                     /transl_table=11
                     /translation="MRRLTYFIATSVDGFIGAPDGDGDFFYSHLDAEFVGFLAAEYPET
                     ISAQGRVQLGIADAAPKRFDAVIMGRRTYEPGLEQGMTSPYGHLPEQYVVSRSLAAPPD
                     PQVRLISGHLAAEVRELKARDGLGIWLCGGADLATQLIDEIDEIIVKTYPVFAGTGMPM
                     SRAGFGARPLELTAVRTFGGGQVVTTYARGR"
     gene            12510..12713
                     /locus_tag="IE257_RS25775"
                     /old_locus_tag="GCM10010343_53190"
     CDS             12510..12713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266474.1"
                     /locus_tag="IE257_RS25775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53190"
                     /product="hypothetical protein"
                     /protein_id="WP_189972297.1"
                     /transl_table=11
                     /translation="MAGEQQHHAHETVAPQAGHEQQACPACGRRVDTVVRRRKSLGIFI
                     PVWGRGPCRNPDCRDYANPEER"
     gene            complement(12715..13383)
                     /gene="snpA"
                     /locus_tag="IE257_RS25780"
                     /old_locus_tag="GCM10010343_53200"
     CDS             complement(12715..13383)
                     /EC_number="3.4.24.77"
                     /codon_start=1
                     /gene="snpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266475.1"
                     /locus_tag="IE257_RS25780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53200"
                     /product="snapalysin"
                     /protein_id="WP_189972298.1"
                     /transl_table=11
                     /translation="MRHSRKAMLATTVGLGLAATLGVVPTATAAPAPVGSAVSYAAYEG
                     SPENAAANRAFFEAVQRSVAEQRAANPGALAVTVTYNTRSAPSFRTQIARSTQIWNSSV
                     SNVKLQEVSSGGNFSYREGNDSRGSYASTDGHGRGYIFLDYRQNQQYNSTRVTAHETGH
                     VLGLPDHYSGPCSELMSGGGPGTSCTNATPNSAERTRVNQLWANGFASGLGAKDLATKG
                     "
     gene            13594..14529
                     /locus_tag="IE257_RS25785"
                     /old_locus_tag="GCM10010343_53210"
     CDS             13594..14529
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889347.1"
                     /locus_tag="IE257_RS25785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53210"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_189972299.1"
                     /transl_table=11
                     /translation="MELEVRHLRALCAIADAGSLHKAARQLGVSQPSLTTQLRRIERAL
                     DGELFLRERTGCRPTPFGRTVLGRARPLLAEMAALVAEARELAHASRLRIGSTASSALP
                     GWLRRIHRRLPDTETSLVVDVSANALLRMVAAGQLDVAFVHEVEGSPLRVPPGLQMHVL
                     MEREPQFVSMSRDHPAAGQAVVSLRDLAADRWMVDPSVDGEWDGLRRVFAGAGLDPPVL
                     HADYHTATSLIISGEAVAPCQPTSGPREDMAIRPLCGDPLAVRLLLATRPGAHAEVYED
                     LRAAYREAALRTPPYRAWLHHHASPLLEVA"
     misc_feature    14152..14154
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14546..15355)
                     /locus_tag="IE257_RS25790"
                     /old_locus_tag="GCM10010343_53220"
     CDS             complement(14546..15355)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966322.1"
                     /locus_tag="IE257_RS25790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53220"
                     /product="hypothetical protein"
                     /protein_id="WP_189972373.1"
                     /transl_table=11
                     /translation="MSRTVTGGLLLCRAEPLAVRRPAHLLRVRLLLAPAGEWSVLVPED
                     KPWRDGPETVAEVLSGWGSALAIGTDWPVLGLWWQDGRTGFALSSGFRRTAAYGWDAAG
                     RPAGEPDAMRALSARLGLDPVLDLAELERLTRADADPAVDGEGRLLALVALLTRAGLAL
                     PAGLAPGEPADRLRAAARVAPDVETVEWSGWPDAVRAELDAVEGGPLGPWVRGPRARML
                     GAAQVAAGAPLLAWAAHRRSPGWAAAGAVLLAQGAAALAYDRARARR"
     gene            15510..16466
                     /locus_tag="IE257_RS25795"
                     /old_locus_tag="GCM10010343_53230"
     CDS             15510..16466
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470758.1"
                     /locus_tag="IE257_RS25795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53230"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_189972300.1"
                     /transl_table=11
                     /translation="MAEQSPESPQPSPAPSTWHFAEPRKLTFEEPVTELRVRIVSGTVN
                     VVAAEEGPARLEVTEVDGPPLYVVQDGGTLTVSYEDAPWNGSHGLKEWFESKPWKAWSG
                     SFSGRKAWERSAAITLTVPAGTQVRVAAVDAVSFVSGISGGTDVNGVSGDATLVGLSGR
                     VKAHTVSGSVEAQSVTGEFGFHSVSGGLTVVDGAGVKVRADSVSGDMLIDLDPGPEDAG
                     PVDIALNSVSGQVAIRLPHPADARVEANTATGRVSNAFEDLRVSGQMGAKRITGTLGSG
                     AGTLRATTVSGSIALLRRPQAEADTPAAPLALDKKVL"
     gene            16468..17436
                     /locus_tag="IE257_RS25800"
                     /old_locus_tag="GCM10010343_53240"
     CDS             16468..17436
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154110.1"
                     /locus_tag="IE257_RS25800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53240"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_189972301.1"
                     /transl_table=11
                     /translation="MPPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAG
                     TVYPRLAKLEAEGLVTYATEGGRKVYSITEAGRAELADRGGELADLELEIRDSVTELAA
                     EIRSEVRGAAGDLRREMRAAASASATRTAEEESWQTAKEELRKARQEWKEQARRAKDES
                     RRAREEAQQARRQAKEAQERAREEVQRIAGQLQEQFARSGGVLGSLAGAWLGGGTPTPT
                     TAPGAAAPAGPADVADAAAPADADADVDADVDADRASHWAVDLAPTGDPARDLDRLLDR
                     FRDEVRDAARDRGVTAAQVAEARRHLEAASRRLGTTFGARS"
     gene            complement(17720..18292)
                     /locus_tag="IE257_RS25805"
                     /old_locus_tag="GCM10010343_53250"
     CDS             complement(17720..18292)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266479.1"
                     /locus_tag="IE257_RS25805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53250"
                     /product="Clp protease N-terminal domain-containing
                     protein"
                     /protein_id="WP_189972302.1"
                     /transl_table=11
                     /translation="MFERFTRDARSTVTGAVTEARRSGAATVTEEHLLLSLLALGILDP
                     LGVDRAAVAADLTAARRRGGMSRADEEALAGLGIDLTEIVSRIEETHGEGALAAAAPRR
                     RTLGSSLRSVLGREDADDRAGSRHVPFTEGAKKVLEQSLRIALGRRDNHIGTLHLLLAL
                     LSRPGTASEVLTDHGITYRTAETTLAA"
     gene            complement(18292..18501)
                     /locus_tag="IE257_RS25810"
                     /old_locus_tag="GCM10010343_53260"
     CDS             complement(18292..18501)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005312042.1"
                     /locus_tag="IE257_RS25810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53260"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_030385998.1"
                     /transl_table=11
                     /translation="MTEATDLAERAGDRDPRVGLRAVSALRRLLEQLEAVQVRSARAQG
                     WSWQEIAAELGVSRQAVHKKYGRL"
     gene            complement(18570..19532)
                     /locus_tag="IE257_RS25815"
                     /old_locus_tag="GCM10010343_53270"
     CDS             complement(18570..19532)
                     /NRPS_PKS="Domain: PKS_ER (17-318). E-value: 4.2e-34.
                     Score: 110.0. Matches aSDomain:
                     nrpspksdomains_IE257_RS25815_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966331.1"
                     /locus_tag="IE257_RS25815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53270"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_189972303.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.7e-21, bitscore:
                     70.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAAYAARIDRDQPLNGLELGDRPAPEARPGWVTVNVKAASFNHH
                     DLWSLRGVGLGEERLPMILGCDAAGIDQDGNEVVLHSVIGQSGHGVGPDEPRSILTERY
                     QGTFAEQVTVPAWNVLRKPAELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAG
                     GGVATAAIALGKAAGLRVFATSRDEAKRKRAVELGAVEAYEPGARLPQRVDAVIETVGA
                     ATWSHSVKSLRPGGTLVISGATSGDRPAHAELTRIFFLELKVVGSTMGSKDELEDLLAF
                     CATTGLRPVIDEVLPLDRAREGFEKLASGDLFGKIVLTP"
     aSDomain        complement(18579..19481)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS25815_PKS_ER.1"
                     /evalue="4.20E-34"
                     /label="IE257_RS25815_PKS_ER.1"
                     /locus_tag="IE257_RS25815"
                     /protein_end="318"
                     /protein_start="17"
                     /score="110.0"
                     /tool="antismash"
                     /translation="LELGDRPAPEARPGWVTVNVKAASFNHHDLWSLRGVGLGEERLPM
                     ILGCDAAGIDQDGNEVVLHSVIGQSGHGVGPDEPRSILTERYQGTFAEQVTVPAWNVLR
                     KPAELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIALGKAAGLR
                     VFATSRDEAKRKRAVELGAVEAYEPGARLPQRVDAVIETVGAATWSHSVKSLRPGGTLV
                     ISGATSGDRPAHAELTRIFFLELKVVGSTMGSKDELEDLLAFCATTGLRPVIDEVLPLD
                     RAREGFEKLASGDLFGKIVL"
     CDS_motif       complement(19014..19073)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS25815_0002"
                     /evalue="2.80E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE257_RS25815"
                     /protein_end="173"
                     /protein_start="153"
                     /score="16.7"
                     /tool="antismash"
                     /translation="GDSVLVQGAGGGVATAAIAL"
     CDS_motif       complement(19104..19142)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS25815_0001"
                     /evalue="5.60E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="IE257_RS25815"
                     /protein_end="143"
                     /protein_start="130"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AACLPTAWLTAYR"
     gene            complement(19724..20926)
                     /locus_tag="IE257_RS25820"
                     /old_locus_tag="GCM10010343_53280"
     CDS             complement(19724..20926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266483.1"
                     /locus_tag="IE257_RS25820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_53280"
                     /product="NADP-dependent malic enzyme"
                     /protein_id="WP_052873800.1"
                     /transl_table=11
                     /translation="MAAEIINPRSDSVTDNNPDAVFALHRGGKMAIQATVPVTNKDDLS
                     LAYTPGVAKVCSAIAEQPELVNEYTWKSNVVAVVTDGTAVLGLGDIGPEASLPVMEGKA
                     ILFKQFGGVDAVPIALATKDTDEIIETVIRLAPSFGGVNLEDISAPRCFEIERRLQEAL
                     DIPIFHDDQHGTAIVTLAALRNAAKLTGRTLGDLRAVISGAGAAGIAIAKILVDAGIGD
                     VCVTDRKGVVSADRSDLTDVKAEIAGLTNRTGQTGSLETALNGADVFIGVSGGTVPEEA
                     VASMAKDAFVFAMANPNPEVHPDVAHKYAAVVATGRSDFPNQINNVLAFPGIFAGALKV
                     RATRITEGMKIAAADAIAGVVGDELAADYVIPSPFDERVAEAVATAVAAAAKADGVARL
                     V"
     misc_feature    20886..20898
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: strong, score: 25.59"
                     /tool="antismash"
ORIGIN
        1 cggttgggct cctcccagaa ctggcgcatc agctgtcgca catacagagc gtgggtcgaa
       61 cgcttgccgc gctcgcgctg ctgctccacc cggcccacca cgccggcgtc gaagccgaag
      121 cccgcgcaga aggtgaacca gcgggccggg accgactcgt cctccgtgcc cggggtgccg
      181 gccgccaggc ctagacccac cgtccgctca cgctgctccc gcagcgcgtc caggagcgcg
      241 ccggtcgcct cgaccgcgtc gttgggcagc cccagggcgc gggcgaagac attggtggag
      301 ccgccgggaa ccaccgccag ccgggggagg cgctccgggt cgggcccgtt gtgcaggagc
      361 ccgttcacca cctcgttgac cgtgccgtcg ccgcccagtg cgacgacgag gtccagcccc
      421 tcgtgcgcgg ccttgcgccc caggtcccgg gcgtgcccgc ggtactcggt ggtgaccgcc
      481 tccagcttca tctcgctggc cagggcatgg gtcaggacgt cgcgcgtgcg cgcactggtg
      541 gtcgtcgctg ctgggttggc cacgagaagt gcacgcatga gcgccagact acccaccccc
      601 tcacatgccg accgtactgc ccgtcccctc ggggcccggg gccgcgccgc taccctgctg
      661 gggtgagtaa gaagcagccc gcgaatgccc ccgcccccgc cgccgccccg cccgccgcgc
      721 tgcccggccg gctgaccgcg gccgccgcgc tcaccgccct ggaaggcctg gcgctggccg
      781 gcctcgggct ctacatgttg ttcgtgggga tcgccggcga ccccgattcc ccgcagcagg
      841 ccgagacggg cgggatcact ctgctcgcac tggccgcgct gccgctgatc gcggcccggg
      901 ggctgcgcct gggccggcgc tggagccgcg gtccggcact gatcacccag ctgatggcgc
      961 tgccggtggc ctggaccctc tacagcacgg gcggcgcgat gatcgccgcc gccgtggcgc
     1021 tggccctggc cgcggtggcc gtcgtagcgc tcctggtgaa cccgacggcg accgaggctc
     1081 tcggtatcgg gcccggggaa caggcccgat aaccggtcgt ccggttcccg gcgcaccgcc
     1141 gtacccggct gcctactcct cgacgaggag cttgtcgcgg agctgggcca gggtgcgggc
     1201 cagcagccgg gagacgtgca tctgggagat gccgacctcc tgggcgatct gcgactgggt
     1261 catgttgccg aagaagcgaa gcagcaggat ccgcttctcc cgcgggggca ggccctccaa
     1321 cagcggcttg agggactcgc ggtactcgac gccctccagg gcctcgtcct ccgcacccag
     1381 ggtgtccgcg accgccggcg actcgtcgtc ggtgtccggg acgtcgaggg acagcgtgct
     1441 gtaggcattg gccgattcca gcccctccag cacctcctcc tcggagatcc ccagccgttc
     1501 ggcgagttcg tgcaccgtcg gggagcggcc gtgctgctgg gacagttcgg ccgtggccgt
     1561 cgtcagcgag agccgcagct cctgaaggcg acgcggtacg cgcaccgccc agcccttgtc
     1621 acggaagtgg cgcttgatct cgccgaccac cgtgggcgtg gcgtacgtgg agaactcgac
     1681 cccgcggtcc gggtcgaacc ggtccaccga cttgatcagt ccgatcgtcg cgacctgggt
     1741 caggtcgtcc agcggctcac cgcggttgcg gaagcgccgc gccaggtgtt ccaccagcgg
     1801 caggtgcatc cgtaccagcc ggttgcgcag ctccgccttc tccaccgacc cgtcgggcat
     1861 tgcccgcagc tcgatgaaca gggcccgcgc gccactgcgg tcgcgcggat ccggcagcgc
     1921 gtgcgacacc gggagcaccg gcgctgccgg taccaccggt gccagctccg gggccgtggc
     1981 agcggcctcg gtcggctggg gtgattgtgg ttgttcctgc tggttctcgc tcatagggcc
     2041 cgcccgtcgc tccgccgagt ccaaaaagcc gtcttccgca tccgcgtcag ccgggtgcgg
     2101 tcgggcgtgc tgctgctccg ggatgccgcc gtcgacctcg tgccgtaccc ggggccgatc
     2161 cccgccccgt accgggatct ccccgccgct cacgccgggc ctggtcccgc gccgcgctgt
     2221 ttgtagaggc tgatgctcac cgtccggttc tcctcgaccg tggcctcgac cttgccggcc
     2281 agcgccgaca ggacggtcca cgcgaacgtg tcacgctccg gtgcgcgccc gtcggtggtc
     2341 ggtgccgaga cggtcacctc cagcgaatcg tcgatcagcc ggaacacgca actgaggacg
     2401 gagccgggca cggcctgctg gagcaggatc gcgcaggcct cgtccaccgc gatgcggagg
     2461 tcctcgatct cgtcgagggt gaagtccaaa cgtgccgcga ggccggccgt ggccgtccgc
     2521 agcaccgaca ggtaggcacc cgcagcgggc agccggactt ccacgaagtc ctgagtcccg
     2581 ggctcgcctg caatctggga caccctcacc tccaaggtgg tacgagctct gttcgccggt
     2641 gacgctatcg cgatccgggc gatcgtgtcg cggcacccct cttggtgccc gcttcgtgca
     2701 cctcgtctgc gagccagtga ctgatggtaa gcccatgggt acgcacagtg gctagaggtc
     2761 tgcggggccc aaatcagggg aaccggcgga gggttgaact accccgcttc agacgatcga
     2821 accgtcgaca aaacaccagc gccaggtctc acccggttcg aagctccgca tcaccggatg
     2881 gcccgtgtcc ttgtggtgcg ccgtggcgtg ccggtggggc gaggaatcac agcaggccac
     2941 gtgcccgcac cccaggcaca tccgcagctg cacggggtgg ctgccgagcg ccaggcactc
     3001 ggagcaggtg tcgtgggagg gcaccggttc gggacgcggc agttcggcaa cgtgggtgca
     3061 ctcgctcatc gcattctcct tgtaccggaa ccccggcctt cagtctcggg gcgaaccgcg
     3121 cgcacgggcc ggagctgcga tgcagcggag tgtcgatgcg tcacgctttg accggagctt
     3181 gatctcgtac agaatacgtt cccgccgtgc gagtcatgag gatctcctcg gtcaagcccg
     3241 cgcgttcggg gcgaccggcc gacgattgag gtggatcttc gatggaggta ttgccgctgg
     3301 tggcgctgat cgccggcagc gcggccgtcg cggggctggc ccgccggacc ccggtgcccg
     3361 cgccgctgct gctggtcgcc gccggcctgc tggccgggta cgtgccgggg gtgcccgcgt
     3421 acgcactcga cccgcacatc gtgctgccgc tgctgctccc gccgctgctg tacacggccg
     3481 ccgtggacag ctcgtacctg gacctgcgcg cgaacatccg gcccatcgcg atgctctcgg
     3541 tgggctacgt gctcttcgcg acgctcgccg tcgggtacgc ggcgtacctg ctggtgccgg
     3601 ggctctccgt gccggtggcc ctggtgctgg gcgcggtgat cgccccgccg gacgccgtcg
     3661 ccgccaccgc gatcgcccgc aagctgcggc tgccgaaccg catcacgacc atcctgcagg
     3721 gcgagtccct ggtcaacgac gcgaccgcga tcaccgccta caaggtggcg ctggccgcgg
     3781 ccgtcggggt gagcgccggc tgggcgggcg gcatcgcgga gttcctgctg gcctcggtcg
     3841 gcgggatcgg cgtgggcctg ctgctgatgg tgccgatcca ccacctgcgc acgcggctga
     3901 aggagccgct gctccagaac accctctcgc tgctgatccc cttcgtggcg tacgcggccg
     3961 cggagcgggt gcacgcctcc ggggtgctgg ccgtggtcgt cgtcgcgctg tacctcgggc
     4021 accgcaactg gcaggtcgac ttcgccaccc ggctccagga ggaggcggtg tggaaggtgg
     4081 tcgccttcgt gctggagtcc gtggtcttcg cgctgatcgg gctccagctg ccggtggtcc
     4141 tgggcgggct gggggagtac gacggcatgc acgcggccac ctacgcggtc gccgtgttca
     4201 tcgcggtggt ggtggcccgg ttcctgtggg tgttcccggc gaccttcgtg ccgcgctggc
     4261 tgtcggagcg gatccgggcg cgggagagcg acaccgactg gaaggccccg gtgatcgtgg
     4321 gatgggccgg gatgcgcgga gtggtctcgc tggccatcgc cttctccgtg cccatgtcgg
     4381 tgccgcaccg gaacctgatc ctcttcctga ccttcaccac ggtcatcggg acgctggtgg
     4441 tgcaggggct gacgctgccg ccgctgatcc gggtgctgaa cctgccgccg aaggacgtgc
     4501 aggccgagac cctggccgag gcgcaggcgc agagcgaggc ctcgcgggcg gcggaggaac
     4561 ggctggcgga gctgctggag gaaccggaga acagcacgct gccgccgccg ctggcggacc
     4621 ggctgcggac ggtgctggag cggcggcgca acgcggtgtg ggagcggctg ggcgaggtca
     4681 acccggagac gggggagtcg gcggacgaca tctaccggcg cctcgcgcgg gagatgatcg
     4741 cggccgagcg ggaggtcttc gtgacgctgc gggaccagcg gcggatcgac gacgagatgc
     4801 tgcgggcgct gctgcgccgc ctggacctgg aggaggccgc ggcctaccgc gaggagggct
     4861 gaggccgggc gtcgcggccg ggtcggcagg cacccgctac ggccggcccg tgacgacggc
     4921 ggcgagggtc gtgccgggcg cgaaggcgcc ggacgcggtg agttcggtca gggcccagag
     4981 cagcttggcc acgtagatgc gctcgaccgg caggccgtgg cgggacccga agtcggcggc
     5041 gaaggcctcc agctcggccg ggacccgggc gtagccgccg tggtggaagt cctcggccag
     5101 cgcccagtcg ccggccggcc ccccgaaggc ggccgcctgg agggaacgta tctccgcggc
     5161 caggaacccg cccgccagga ccggaacccc gagcgcccgc tgcccggtgc ccagcccggc
     5221 cgcgaggccc gccagggtgc cgccggtacc gcaggccacc gccaccacgt cggcggcgcc
     5281 gcgcagttcc cggccgagct cggcgcagcc gcccagggcg agcgcgttgc tgccgccctc
     5341 ggggacgacg tacgcaccgg ccgcgcccgc cgcgtccacc agccgtgcca gtcggtgcgg
     5401 ctcggccttg cggcggtact ccgaccggga cacgaagtgc agccgcatgc cgtccgcggc
     5461 gcaccgggcg agggactcgt tcaggggccg cccggccagc tcgtccccgc gtacgatgcc
     5521 gaccgtccgc agcccgagca gccgcccggc ggcggcggtg gcccgcaggt ggttcgagta
     5581 cgccccgccg aaggtgacca gttgatcgtg gccgccctcc agggcggccc ggagattggg
     5641 cgcgagcttg cgccacttgt tgccgggcaa ctcgggatgc acgaggtcgt cccgcttcag
     5701 cagcagccgc acgccgtacc gcccgaacct gtcgtccgcc gcctcgacga gcggagacgg
     5761 cgggcgcggc agcagttcgg aatgggtcac caggtcattg tccctggtgg gggcccgatt
     5821 acttcaggcg ctcgccgatc cgggcgcgca tggcgtccat cgtgaagccc ctggggtcga
     5881 ccttgcccgg ctgccattcg cggtggccga tcaccgagcg ggacgtccag cggtggaccc
     5941 ggcacagggc cgccgcggcg cgggcgatgg cgtcgagctg gaccgccggc caggggtcct
     6001 cgccgtcgcc caggttctcg cactcgaagc cgtagaagtg gcggttgccg tcggtgtccg
     6061 tctcgttgtc cggcgggagg cgcttctccg cgatcaccgc agcgaggacg tcggagtcgc
     6121 cggcgcccgc gtggttggcg cggccgtagc cgacgaggtg gacgcggccg tccttggcga
     6181 tcacgccgtg acacaggggg ccgggcaggg cgctgtggcc ctcgcggcag agctcgacgg
     6241 tgcgggcggt gccgcgggtg acggtgtggt ggatcatcac cccgtggacc ggtccccagg
     6301 ggcccttgtg gttgcggttg tgggtccgcc aggcgccgac ttcgacgacg gtcagaccct
     6361 cgttccgcag tgcgttgatg aaacggtccg cggacatggg tgcggccatg gccgcctcct
     6421 tcgttgcggt gcgtgacgac accctctgtg ctcgtctcgt caccctccgg tttagtggag
     6481 gcggcccttc cgcgctagtg ctttcgtacg gcgagcgagc cgatccggcc aggcgtcaga
     6541 ccgatgcgag ccacaggtcc gggccgaaga cctcgtagtg gatgtcggcg gccggcagcc
     6601 ccttggcgat cagctgctcg cgaaccgcac gcatgaaggg gagcggcccg cacaggtagg
     6661 cccgggtgcc cggggcgacg gcgacggccg agaggtccat gcggccctcg ccgtcgcccg
     6721 gctccgccgc ctcctcgtac cagaaccggg ccgaggcgtc cggcagcttg tgggtcagcg
     6781 cccggtgatc gctccgcagc gggtggtcgg cgggggagcg gtcggcgtgc agcacggtca
     6841 ccggggcggt gtgcccggtg tcggccaggt gctccagcat cgacagcatc ggggtgcagc
     6901 cgatgccggc cgaggcgagc aggaccgggg cggccgagtc cgccggcacc aggtcgccgt
     6961 acggggccga gacccgcagg gtgtcgccgg tgcggacccg ggcgtgcagg tggttggaga
     7021 cctcaccggc cgggcccgcg gcggccgggc cgtggatccg cttgacggtg atcgcgcgga
     7081 ccgcggagcc gggcgaggtg atgaggctgt actggcggat ctggcgggcg ccgtccggga
     7141 gttcgacctg gaccgagacg tactggcccg gccggtgcgc gggagcgggg gcgccgtccg
     7201 cgggggcgat ccggaaggtg gtgcagtccg ccgtctccgc cacccggtcg gtgacggtcc
     7261 actcgcgcca cacgtcgccg gcgacgaccc gctgctcggc gtagaggcgc tcctccaggg
     7321 cgatcagggc gttcgccatc agccagtaga cctcgtccca ggcccgggcg acctcggggg
     7381 tgacggcctc gccgaggacc tcgccgatcg cctcgaacag gtgctggtgg acgaccgcgt
     7441 actgctcgcg ggtcacgccg aggctggcgt gcttgtgggc gatgcggttc agcatcacgt
     7501 cggggcgggt gtccgggtgg gcgaggaggt gggtcgcgaa ggcggcgatc gagccggcga
     7561 gggcctgctt ctggaggccg gcgctctggt tgccccggtt gaagaggtcg cggatcagcg
     7621 ccgggtgggc cgcgaagagc ttggtgtaga agagctcggc gatctccccg atcgccgctc
     7681 cgacggcggg cagggtggct cgtacggtcg cggtcgacgt ctcggacagc atgcggaact
     7741 cctcgcgtga tgggcctgtg ggtgtgaccg attgaatttg catctgagat gcgtattttt
     7801 gatcgcagaa ggaccgccgt ggtgcggact tctgttcgga ctcgtgccgg accggttcgc
     7861 tcgggcagcg gtaaccggcc atcccggccg agggtcaggg gctgctgccc gccccggtcg
     7921 gcgccctgct cgaaatgccc agcaggagag gcccggtcgg cgacgccacc aggtcgttca
     7981 ccgtcagcgg gtcgagtgcg gcgtagaagg cctcctgggc ccggcgcagg gcgccgcgca
     8041 ggacgcaggc accgcgcagc gggcaggggg tggtgccttc gcagtccacg acgtccccct
     8101 cgccctccag ttcgcgcacg accgagccga ccggtgcggc ccggccggcg gcggtcaggg
     8161 cgagcccgcc gccgcggccg cgccgtgctt cgaccaggcc gaggtgctgg agcctggcga
     8221 ccactttggc cgtgtgcgtg taggggacct ccatggtcgc cgccacgtcg cgggtggtcg
     8281 ggaggtccgt ctcctcgatg gccaggcgca tcaggacgcg cagtgccagg tcggtgaatc
     8341 gggtcagccg catggggtca ccgtagagaa atatgcatcc gtgatgcaag ttaggtcgct
     8401 gacggtgtcg cgcttggccg aaatcgacgg tcgcgtggtg ctcaaggggc ccgtggggca
     8461 gaagggtgac cccaaagggt gccccgcact cggacggagt agtcccaccc ttttgtgtaa
     8521 tggtccgatc acgttccgta ctgaaaggct gcacccgcag atccatggag tgatcgaaag
     8581 ggaaagacat gtcggtccag gcaggttccg agtccgaggc ccagacaccg cagcgcagtc
     8641 ttgggacgac ggccgcacgg aacttggcaa ccacgaccaa gtccgcgccg cagatgcagg
     8701 agatcacctc gcggtggctc ctgaagatgc tcccgtgggt gtcggtgcag ggcggcacgt
     8761 accgcgtcaa ccgcaggctg agctactcgg tcggcaacgg cgtcgtggag ttcatcaaaa
     8821 ccggcaccca ggtccaggtg atcccggccg agctcggtga gctcccgctg ctgcgcgact
     8881 acgaggacct cgacgtcctc ggcgaactcg cccagcgctg ccggcaggtc gagttcgagg
     8941 ccgggcagga gctcacctcc ttcggcagcc ccgccgacca ggtcttcctg ctcgcccacg
     9001 gccgtatcga ccagatcggc cccggcccct acggcgagga cgccgtcctg gggagcgtcg
     9061 ccgacggtgc gtacttcggc gacgagtccc tcgtcgatga agaatcgatt tgggagtaca
     9121 ccgcccgcgc cgccacctcc ggcaccgcgc tcaccctgtc ccggcaggac ttccagctcc
     9181 tcgccgaccg ggtcgaatcg ctgcgcgcgc acgtggacaa cgtacggagc cggcccgacc
     9241 ggcagaccaa caagtacggc gaggccgcga tcgagctttc cgccggccac cagggcgagg
     9301 cagtcctgcc cggcaccttc gtcgactacg aggcccggcc gcgcgagtac gagctctcca
     9361 ttgcacaaac ggtcctgcgc gtccacagcc gcgtcgccga cctctacaac cacccgatga
     9421 accagaccga gcagcagttg aggctcacgg tcgaggcgct gcgcgagcgc caggagcacg
     9481 agatgctcaa caaccgcgac ttcggcctgc tccacaacgc ggactacgac cagcgcatcc
     9541 agccccacga cggcgcgccc agccccgatg acatggacca gctgctcagc atgcggcgcg
     9601 gctccaagct gttcctggcg caccccaagg cgatcgccgc cttcggccgc gagtgcaaca
     9661 agcgcgggat ctaccccgag tcggtggaca tcggcggcaa ccgcgtcccg gcctggcgcg
     9721 gggtgccgat cttcccgagc aacaagatcc cgatcagcga cgcccgcacc acgtccatcc
     9781 tgtgcatgcg caccggcgag gacgagcagg gcgtgatcgg gctccaccag ccgggcatcc
     9841 ccgacgagat cgagccgagc ctgtcggtcc gcttcatggg catcagcgag caggcgatca
     9901 tctcgtacct ggtcaccgcc tacttctcgg ccgcggtgct ggtgccggac gcgctcggcg
     9961 tgttggagaa cgtcgagatc ggccgctggc gctgaccgcg gtgaacacca tcgtgaccgg
    10021 tgagggccag gacgccacgg ccctcctgga ccggacgaga gaagcggtcg acccgcagct
    10081 gcgccgcacc gtcgagagcc tgccgggctc gatgcggcgg gtggcgatgt accacttcgg
    10141 ctgggagcac gaggacggca gccccgcggc gggcggcgcc gggaaggcca tccggccggc
    10201 cctggtgctg gcatcggcgc aggccctgcg cggtccgggt gccgggccgg ccgacgaggc
    10261 cgtgcgggcg gcggccgccg tggagctggc gcacaacttc acgctgctgc acgacgacat
    10321 catcgacaag gacgcacggc ggcgcggccg ggccacggcc tggaccgtct tcgggacgcc
    10381 ggacgccatc atcacgggcg acgcgatgat ggcgctctcc ctgcggctgc tcgcggagga
    10441 tccgcatccg gccgccgcgg cggcctcggc ccggctcgcc gcctgcatca tcgagctgtg
    10501 tgcgggccag caggccgact gcgccttcga gcagcggccg gacgtctcgc tcgacgagtg
    10561 cctggccatg gccaccgcca agaccggggc actactgggg tgcgcgtgcg cgctgggcgc
    10621 cctgtacgcg ggggccgggc ccgacgaggt cgacgccatg gacgcgttcg ggcgggaggc
    10681 cgggctggcc ttccagctga tcgacgacct gatcggcatc tggggggacc cgggacacac
    10741 cggcaagccc gccggggccg acctgatcgc ccggaagaag tccctcccgg tcgtggccgc
    10801 cctcacctcg gacaccgccg cggggaagga gctggccgcg ctgtatgccg gccccatggc
    10861 cggggacgac gtacgcaggg cggccgacgc cgtggaccgg gccggcgggc gggactgggc
    10921 gcaggccgag gccgcggacc ggatggggcg ggcggtccag cagctgtccc gggccgtgcc
    10981 ggacctcggg gcggcgggcg ggctgctggc actcgcggag ttcgtgacgc gtcgcacgag
    11041 gtgagcccga ggggctccac gggcccgagg cccgttccgg taccccatgg tgccggaacg
    11101 ggccttaccg catgtccgcg ccaactctag gatcgctcac ggttgttgac ctgtgacgtg
    11161 agtgaagggt gtgaccagtg gcgctggaga tacgacaggc ggatcagtcg gaccgggacg
    11221 cggtggcgcg gctgctcgac gagtccttcc gcaccgaccc ggtgagcagc tgggtcttcc
    11281 cggacccgga gcaccgcgcc gcggtgcacg gaaagttcct cggcgtcttc gtggacgtgg
    11341 cgctggagga gggccggatc gactacgcca cggacggttc ggcggccgcg ctctggctgc
    11401 ggatcccggc gggcgatccg gagggggagg tcgtcgagga cgaggtcccg gcgcggatgc
    11461 gggccgtggc ggaccccgac aacgagcggt gcgagctggt gggacgactc acgggcgcgg
    11521 tgcacccgac ggcggaggag cacgagtacc tgctgatgat cgcggtcgcc ccggaccggc
    11581 agggtcaggg gctgggcagc gagttgatgc ggccggtgct ggagcgctgc gaccgcgagg
    11641 gggtgccggc ctatctggag gcgagcagtg agcgcagcaa ggagctctac gagcggctcg
    11701 gctgggagtt cacgggggag gtggtgcggc tccccgaggg gccgctgatg tggccgatgt
    11761 ggcgcaaacc gcgcggctga ggctcgcggt cccgcaccgg gggtgaatgc ccttgcgtaa
    11821 ccactacagg cgaagtactt taggcgacgt gccccggtgt ggcggcaccc ccagtgaaag
    11881 agaatcgctt gcgcaggctc acgtacttca tcgccacctc cgtcgacggg ttcatcgggg
    11941 ccccggacgg tgacggcgat ttcttctaca gccacctcga cgcggagttc gtcggattcc
    12001 tcgcggccga ataccccgag acgatctcgg cccaggggcg cgtccagctc gggatcgccg
    12061 atgccgcccc caagcgcttc gacgcggtga tcatgggacg gcgtacctac gagccgggcc
    12121 tcgaacaggg catgaccagc ccctacggtc acctgcccga gcagtacgtc gtctcccgct
    12181 ccctcgccgc cccaccggac ccgcaggtcc ggctgatcag cggccacctg gcggccgagg
    12241 tgcgcgagct caaggcgcgg gacggtctcg gcatctggct ctgcggcggt gcggacctcg
    12301 ccacccagct gatcgacgag atcgacgaga tcatcgtcaa gacctacccg gtcttcgccg
    12361 gcaccggcat gccgatgtcg cgcgccggct tcggagcgcg ccccttggag ctcaccgcgg
    12421 tcaggacctt cggcggcgga caggtcgtga ccacctacgc gcgggggcgc tgacccgccg
    12481 aacgcgcaga accggcctac cgtggaggta tggccggtga acagcagcac cacgcgcacg
    12541 agacggtggc cccgcaggcc gggcacgagc agcaggcgtg cccggcgtgc gggcgccgcg
    12601 tcgacacagt ggtcaggcgg cgcaagtctc tcgggatctt cattccggtg tggggtcggg
    12661 gtccctgccg gaaccccgac tgccgtgact acgcgaaccc cgaggagcgg tgactcagcc
    12721 cttggtggcg agatccttcg cgccgaggcc cgaggcgaag ccgttggccc agagctggtt
    12781 gacccgtgtc cgctcggcgg agttcggggt cgcgttcgtg cacgaggtgc ccgggccgcc
    12841 gcccgacatc agctcgctgc acgggcccga gtagtggtcc ggcagaccca gcacgtggcc
    12901 ggtctcgtgc gcggtcaccc gggtggagtt gtactgctgg ttctgccggt agtcgaggaa
    12961 gatgtagccc cggccgtgcc cgtccgtgct cgcgtacgag ccgcgtgagt cgttgccctc
    13021 ccggtacgag aagttcccgc ccgaggacac ctcctgcagt ttgacgttgg acaccgagct
    13081 gttccagatc tgcgtggagc gggctatctg ggtgcggaag ctgggggcgc tgcgggtgtt
    13141 gtacgtgacg gtcacggcga gggcgccggg gttggcggcg cgctgctcgg cgaccgagcg
    13201 ctggacggcc tcgaagaacg cgcggttcgc ggccgcgttc tccggcgaac cctcgtacgc
    13261 ggcgtagctg acggcgctgc cgacgggggc gggcgcggcg gtggcggtgg ggacgacacc
    13321 aagggtggcg gcgaggccga ggccgacggt cgtggccagc atggccttac gggagtggcg
    13381 catgtggggg agctcctact cgtccggtgc ggtggggggt ggtctttcgg taccggagtc
    13441 tgcgggagca caagcgcccg gcggatgatg tcagtccccg atagcgcggg cctatcggga
    13501 agatttcgga agcccaacaa gcgtgagaat ggcgggattc ggggggctat cggtggctgg
    13561 tgcggtccgt agggaccggc ctaccctcag ggcatggagc ttgaggtcag gcacctgcgc
    13621 gccctgtgcg ccatcgccga cgccggaagc ctgcacaagg ccgcccggca actcggcgtg
    13681 agccagccct ccttgacgac acagctgcgc cgcatcgaac gggccctcga cggcgaactg
    13741 ttcctgcgcg agcggaccgg ctgccggccc acccccttcg gccggaccgt gctgggccgg
    13801 gcccgcccgc tgctcgccga gatggccgcg ctggtcgcgg aggcccgcga actggcccat
    13861 gcctcaaggc tgcgcatcgg ctccaccgcc agcagcgcgc tgccgggctg gctgcggcgg
    13921 atccaccggc ggctgccgga caccgagacc tcgctggtgg tggacgtctc cgccaacgcg
    13981 ctgctcagga tggtcgccgc ggggcagctg gacgtggcgt tcgtgcacga ggtggagggc
    14041 agcccgctgc gggtgccgcc cgggctgcag atgcacgtac tgatggagcg ggaaccgcag
    14101 ttcgtgtcga tgtcccggga ccatccggcc gccggtcagg cggtggtctc cttacgggac
    14161 ctcgccgccg accgctggat ggtggatccc tcggtcgacg gcgagtggga cgggctgcgc
    14221 cgggtcttcg ccggggccgg gctcgacccg ccggtcctgc acgccgacta ccacacggcg
    14281 acctcgctga tcatctccgg cgaggccgtc gcgccctgcc agccgacctc cgggccgcgc
    14341 gaggacatgg cgatccggcc gctgtgcggg gaccccctcg ccgtgcgcct gctgctggcg
    14401 acccggcccg gcgcgcacgc cgaggtctac gaggacctgc gcgcggccta tcgcgaggcc
    14461 gcgctgcgga cgcccccgta ccgggcctgg ctccaccacc atgcgagccc gctgctggag
    14521 gtggcgtagc ggcggatccc cccggtcagc gccgcgcgcg ggcccggtcg taggcgaggg
    14581 ccgcggcccc ctgcgccagc aggaccgcgc ccgccgccgc ccagcccggg ctgcggcggt
    14641 gggccgccca ggccagcagg ggtgcaccgg ccgcgacctg ggccgcgccc agcatccggg
    14701 ccctcgggcc gcggacccac gggcccagcg ggcccccctc caccgcgtcg agttcggccc
    14761 gcaccgcgtc gggccagccc gaccactcca ccgtctcgac gtcgggggcc acccgggccg
    14821 cggcccggag ccggtcggcc ggttcgcccg gtgccagccc ggccggcagg gccagtccgg
    14881 cgcgggtcag cagtgcgacc agggccagca gtcggccctc cccgtcgacg gccgggtccg
    14941 catcggcgcg ggtgaggcgt tccagttccg ccaggtcgag gaccgggtcc aggccgagcc
    15001 gcgccgacag ggcccgcatc gcgtcgggct cgccggccgg gcgcccggcc gcgtcccacc
    15061 cgtaggcggc ggtgcgccgg aatccgctcg acagggcgaa gccggtccgg ccgtcctgcc
    15121 accacaggcc gagcaccggc cagtcggtgc cgatcgcgag ggccgaaccc caaccggaga
    15181 ggacctccgc cacggtctcc gggccgtccc gccagggctt gtcctcggga acgagcacgc
    15241 tccattcgcc cgccggggcg agcagcaggc ggacgcgcaa caggtgggcc gggcggcgca
    15301 cggccagagg ttcggcgcgg cagagcagca gcccgccggt cacggtccgg gagattgaca
    15361 tgcccacaca atagagcaaa acaccccaaa tggcggggtt tcgagagggc gcttgacttc
    15421 ccccgaccgc gatatatcgt gttagcagaa gacgcgatat gttgcgtgcg tcgagccccg
    15481 tccgtgtacg cacgaggagg atcagcacca tggcagagca gtcgcccgag tcgccccagc
    15541 cgtcgccggc gccgtcgacg tggcacttcg ccgaaccgcg gaagctcacc ttcgaggagc
    15601 cggtgaccga gctccgcgtc cgtatcgtga gcggcaccgt caatgtggtc gccgccgagg
    15661 agggcccggc ccgcctggag gtgaccgagg tcgacggacc gcccctgtac gtcgtgcagg
    15721 acggcggcac gctgaccgtc tcctacgagg acgcgccctg gaacggctcc cacggactca
    15781 aggaatggtt cgagtccaag ccctggaagg cctggtccgg ttcgttctcc ggccgcaagg
    15841 cctgggagcg cagcgcagcg atcaccctca ccgttcccgc cggtacccag gtccgtgtgg
    15901 ccgcggtcga cgccgtctcc ttcgtctccg ggatctccgg gggcaccgac gtcaacgggg
    15961 tctccggcga cgccacgctg gtcggcctgt ccggccgggt caaggcgcac accgtctccg
    16021 gcagcgtcga ggcccagtcc gtcaccggag agttcggctt ccactcggtc tccggaggcc
    16081 tgaccgtggt cgacggcgcc ggtgtgaagg tacgggccga ctcggtcagc ggcgacatgc
    16141 tgatcgacct ggaccccggc ccggaggacg ccggtcccgt ggacatcgcg ctgaactcgg
    16201 tctccggcca ggtcgcgatc cgcctcccgc accccgccga cgcccgcgtc gaggccaaca
    16261 ccgccaccgg ccgcgtctcc aacgccttcg aggacctgcg ggtctccggc cagatgggcg
    16321 ccaagcggat caccgggacc ctcggctccg gcgcgggcac cctgcgggcg accacggtct
    16381 ccggctcgat cgcgctgctg cgccgcccgc aggccgaggc cgacaccccc gccgcccccc
    16441 tcgcgctcga caagaaggtg ctctgacatg ccgcccgtct tcgcccacgg ccgcctccgc
    16501 ctgtacctcc tcaagctgct ggacgaggcc ccgcgccacg ggtacgaggt gatccgcctg
    16561 ctggaggagc gcttccaggg cctgtacgcg ccctccgccg gcaccgtgta cccgcggctg
    16621 gcgaagctgg aggccgaggg cctggtcacg tacgccaccg agggcgggcg caaggtgtac
    16681 tcgatcaccg aggcgggccg cgccgagttg gccgaccggg gcggcgaact cgccgacctg
    16741 gagctggaga tccgcgactc ggtcaccgaa ctggccgccg agatccgcag cgaggtccgg
    16801 ggcgcggccg gtgacctgcg gcgcgagatg cgggcggcgg cctccgcgtc ggcgacgcgg
    16861 acggccgagg aggagtcctg gcagaccgcc aaggaggagc tgcgcaaggc gcggcaggag
    16921 tggaaggaac aggcgcgccg ggcgaaggac gagagccgcc gcgcccgcga ggaggcgcag
    16981 caggcccgcc gccaggccaa ggaggcccag gagcgggccc gcgaggaggt ccagcggata
    17041 gcgggccagc tgcaggagca gttcgccagg tccggcggcg tcctgggcag cctggccggc
    17101 gcctggctcg gtggcggtac gccgacgccg accacggctc cgggggcggc ggctccggcg
    17161 ggcccggccg acgtggctga cgcggcggcc ccggctgacg cggacgcgga cgtggacgcg
    17221 gacgtggacg cggaccgggc ttcgcactgg gccgtggacc tggcgcccac cggtgacccg
    17281 gcccgtgacc tggaccggct gctcgaccgc ttccgcgacg aggtgcgcga cgcggcccgg
    17341 gaccgcgggg tgaccgcggc ccaggtggcc gaggcccgcc gacacctcga ggcggcttcc
    17401 cggcggctgg gaaccacgtt cggggccagg tcgtaacccg cccgcggcac cgctgccggg
    17461 gcgccgcccc ggaccccgcg cctcgaacgc cggcggggct gggagtgtgg cgccgctccg
    17521 gaccccgcgc ctcgaacgcc ggcggggctg ggagtgtggc gccgctccgg accccgcgcc
    17581 tcgaacgccg gcggggctgg gagtgcggcg ccgctccggg ccctgtgcct cgaacgacgg
    17641 cggggctgga gagtggagcc ccgccggggc tgggaggtcg gcggggccgt aggggtcggc
    17701 gacttcggat gcggggcggt caggctgcca gggtggtttc ggccgtgcgg taggtgatgc
    17761 cgtggtccgt caggacctcg gaggccgtgc cggggcggga gagcagcgcc agcagcaggt
    17821 gcagggtgcc gatgtggttg tccctgcggc ccagggcgat gcgcagggac tgctccagca
    17881 ccttcttcgc cccctccgtg aaggggacgt gccggcttcc ggcgcggtcg tcggcgtcct
    17941 cgcgcccgag gaccgagcgg agcgaggagc ccagggtccg cctgcggggc gccgcggccg
    18001 cgagggcgcc ctcgccgtgg gtctcctcga tgcgggagac gatctccgtg aggtcgatac
    18061 cgagtccggc cagtgcctcc tcgtccgccc tggacatgcc gccccggcgg cgggccgccg
    18121 tgagatcggc ggccaccgcc gcgcggtcga ccccgagggg gtccaggatg cccagggcca
    18181 gcagggacag cagcaggtgt tcctcggtga cggtggcggc gccgctgcgg cgggcctcgg
    18241 tcaccgcccc ggtcacggtc gaccgggcat cgcgggtgaa gcgttcgaac atcagagcct
    18301 cccgtacttc ttgtgcacgg cctgtcggct gacgccgagc tcggccgcga tctcctgcca
    18361 ggaccacccc tgcgcgcggg cgctgcgcac ctgtacggcc tccagctgct ccagcagcct
    18421 gcggagggcg gacacggcac gcaggcccac gcgcggatca cggtcaccgg cccgctcggc
    18481 gagatcagtg gcttcggtca tgcatgtcaa tgtaggttga cgcgggaggg ttcgtcaacc
    18541 ctggttgaca tcagggggct cgggcgggct cagggggtga ggacgatctt tccgaagagg
    18601 tcgcccgacg cgagcttctc gaacccctcc cgcgcccggt ccagcggcag cacctcgtcg
    18661 atgaccggcc gcagcccggt ggtcgcgcag aaggcgagga ggtcctccag ctcatccttc
    18721 gagcccatcg tggagccgac caccttcagc tccaggaaga agatccgcgt cagctcggcg
    18781 tgcgccgggc ggtcgccgct cgtggcaccg gagatcacca gggtgccgcc ggggcgcagg
    18841 gacttcaccg agtgggacca ggtggcggcg cccaccgtct cgatcaccgc gtccacccgc
    18901 tgcggcagcc gcgcgcctgg ctcgtacgcc tccaccgcac ccagctccac ggcccgcttg
    18961 cgcttggcct cgtcccggct cgtggcgaag acccgcaggc cggccgcctt gccgagggcg
    19021 atcgcggcgg tcgcgacacc gccgccggcg ccctgtacca ggacggagtc cccggggcgc
    19081 accccggcat tggtgaacag catccggtac gccgtcagcc aggccgtcgg aaggcaggcg
    19141 gcctcctcga aggacagctc ggcgggcttg cgcagcacgt tccaggcggg gacggtcacc
    19201 tgctcggcga aggtcccctg gtagcgctcg gtcaggatcg agcggggctc gtccgggccg
    19261 accccgtggc cgctctggcc gatcacggag tgcaggacga cctcgttgcc gtcctggtcg
    19321 atcccggcgg cgtcgcagcc gaggatcatc gggagtcttt cctcgccgag gccgaccccg
    19381 cgcagcgacc acaggtcgtg gtggttgaag gaggcggcct tgacgttcac ggtcacccag
    19441 ccgggtcggg cctcgggagc cgggcggtcg cccagctcaa ggccgttcag cggctggtca
    19501 cggtcgattc gggcggcgta ggcagcgaac atgcggcgac gctaccgttc ggtagccccg
    19561 gcatccaccc ccgttcccgt cacacggccg tgcccgtcgc aggttccggg cgcagtgctc
    19621 cggcattgcc cccgtgccga gccgtgcgag gggggcgggg aaaggcagag gcccggccgg
    19681 aatgctccgg tcgggcctct gcgggtactg ctcaggtccg gtgtcagacc aggcgggcca
    19741 cgccgtcggc cttcgccgcg gcggcgacgg ccgtggcgac ggcctcggcg acgcgctcgt
    19801 cgaacggcga cgggatcacg tagtcggcgg cgagctcgtc acccacgaca ccggcgatgg
    19861 cgtcggcggc ggcgatcttc atgccctcgg tgatccgggt ggcgcgcacc ttgagcgctc
    19921 ccgcgaagat gcccgggaac gccagcacgt tgttgatctg gttcgggaag tccgagcggc
    19981 ccgtggccac gaccgccgcg tacttgtgcg cgacgtccgg gtggacctcc gggttcgggt
    20041 tggccatggc gaagacgaac gcgtccttcg ccatcgaggc cacggcctct tccgggaccg
    20101 taccgccgga gacgccgatg aagacgtccg ccccgttcag ggccgtctcc agggagccgg
    20161 tctgcccggt cctgttggtc aggcccgcga tctccgcctt gacgtccgtc aggtcggagc
    20221 ggtccgcgga cacgacgccc ttgcggtcgg tgacgcagac gtcgccgatg cccgcgtcca
    20281 ccaggatctt cgcgatggcg ataccggcgg cgccggcacc cgagatcacg gcccgcaggt
    20341 cgccgagggt gcgacccgtc agcttcgccg cgttgcgcag tgcggctagc gtcacgatgg
    20401 ccgtgccgtg ctggtcgtcg tggaagatcg ggatgtccag cgcctcctgg aggcggcgct
    20461 cgatctcgaa gcagcggggg gcggagatgt cctccaggtt caccccgccg aaggacggag
    20521 cgaggcggat gaccgtctcg atgatctcgt ccgtgtcctt ggtggcgagc gcgatcggaa
    20581 ccgcgtccac accaccgaac tgcttgaaga ggatggcctt gccctccatg acggggaggg
    20641 aggcctcggg accgatgtca ccgagcccga gcacggccgt accgtcggtg acgacggcga
    20701 ccacgttgga cttccaggtg tactcgttca ccagctccgg ctgctcggcg atggcgctgc
    20761 acaccttcgc cacgccgggc gtgtacgcga gggaaaggtc atccttgttg gtgaccggca
    20821 ctgtggcctg gatggccatc ttgccgcccc ggtgcagcgc gaacaccgcg tccgggttgt
    20881 tgtccgtgac gctgtcactg cgagggttga tgatctccgc tgccacttcg tgtgacccct
    20941 taagtccttt gaatcgttga gggtggccac tcctggttaa ggggtgggcg ggcaccgcgt
    21001 ccgtactccg cgtcaacggt tggcccgtct ccgcgaaggg gagg
//
