LOCUS       NZ_BMVL01000005        31903 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence05, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000005
VERSION     NZ_BMVL01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 579474)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 539614
            Orig. end                         :: 571517
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..31903
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="terpene-precursor"
                     /region_number="4"
                     /rules="(micKC and not PKS_KS)"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..31903
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iii"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22715
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22715
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12715](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12715)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(430..448)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.37"
                     /tool="antismash"
     gene            1098..1976
                     /locus_tag="IE257_RS16190"
                     /old_locus_tag="GCM10010343_33410"
     CDS             1098..1976
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS16190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_33410"
                     /product="hypothetical protein"
                     /protein_id="WP_189969104.1"
                     /transl_table=11
                     /translation="MKRVRSLLAVLASLALTATLIALTGSPAVAAPATSRAAPQGHGTC
                     AATAPGSKSQRRGMVWSCPEVGPAPAWVASRMTHKAAPATSTARAAGPGGGQHDGRTPE
                     ELCADASPAAVVSNRLAYCVRGAARYTRLGADNKVEGEAIVGILISSGIKETPNAAWQE
                     KVHVVALKMENMPDGVSIAVSSTCSGICTTQGPAWGGSAVVLREDGEGRSDGVLGYSSP
                     VGKGSKAPHIRPSYHLVGRILGGGIPQPPVNADHPGPSLRCDDQVTRWPGCIVEGHSIL
                     DREPVQVIIAD"
     misc_feature    1112..1126
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(2157..2438)
                     /locus_tag="IE257_RS16195"
                     /old_locus_tag="GCM10010343_33420"
     CDS             complement(2157..2438)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS16195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_33420"
                     /product="hypothetical protein"
                     /protein_id="WP_189969106.1"
                     /transl_table=11
                     /translation="MNRDDAIRACVARGLVDREDLWLDLIGAGRPIPGQGIMFLAWFAE
                     RALSEIETVLVRVRVVDRVGDVHERVLDLFKGVIRHPLAPDPHPFELD"
     gene            complement(2541..3875)
                     /gene="lysA"
                     /locus_tag="IE257_RS16200"
                     /old_locus_tag="GCM10010343_33430"
     CDS             complement(2541..3875)
                     /EC_number="4.1.1.20"
                     /GO_function="GO:0008836 - diaminopimelate decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="lysA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542596.1"
                     /locus_tag="IE257_RS16200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33430"
                     /product="diaminopimelate decarboxylase"
                     /protein_id="WP_189969108.1"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 1.3e-62, bitscore:
                     206.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 5.5e-18,
                     bitscore: 60.0, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAALSEATAGTDDLSVWPASAHGLPHGGLAVGGVSLAEIADRF
                     ETPVYVLDEGEVRARCRSYRDAFPDADVLYAAKAFLSRAMVRWVDEEGLGLDVCSAGEL
                     ELAVTAGFPPDRIALHGNVKSPRDIEAALRLGVGRIVIDSPSEIARLAAAVGTGGPQKV
                     MVRVVPGIMAGGHEKIRTGADGQKFGLALSDGSAQHAIARILGRPELELTGLHCHIGSQ
                     ITEVRPYLAAARRMVGLMARVRDAHGVVLPELDMGGGHGIAYRPGDPSLDVAALARRLR
                     TELIESCAAAGLAVPRLAIEPGRAVAGPAGVALYRVLAVKRTGGRVFVAVDGGMSDNPR
                     PALYGVRYAPRLVGRRSPTAPCVATVVGRHCEAGDILAADVELPGDVHPGDLLALPVAG
                     AYQVSMASGYNMVGRPPVVAVDNGRARLLMRRETLADFHSRDIGG"
     gene            complement(3872..4246)
                     /locus_tag="IE257_RS16205"
                     /old_locus_tag="GCM10010343_33440"
     CDS             complement(3872..4246)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743207.1"
                     /locus_tag="IE257_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33440"
                     /product="SAV_915 family protein"
                     /protein_id="WP_189969110.1"
                     /transl_table=11
                     /translation="MCLFQYEDDPEPEERTPAGLLYVPVRPGTGAGAVVRLFRTPLGVR
                     TAVGFTRPERLAATLGGGQGYIRLSESLLRELCEPLGAELITVDPTLSAPAATGAATRA
                     TTATQRPDRFPVRLARGGTS"
     gene            4547..5065
                     /locus_tag="IE257_RS16210"
                     /old_locus_tag="GCM10010343_33450"
     CDS             4547..5065
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127603.1"
                     /locus_tag="IE257_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33450"
                     /product="universal stress protein"
                     /protein_id="WP_189969112.1"
                     /transl_table=11
                     /translation="MRGRVVAGSCGSLGSLTALHRAAAEARARDAELWVVLAWQPPIGG
                     PGSRGSTGGTPLLAGCRDAAVERLRGILDTAFGASPPGVHLAGLTVRATPGAALVDTVR
                     DPGDLLVVGTGSRAPLLRALRPSVARYCLAHAPCPVLAVPPSPLQADLDAVHRRNVWRR
                     PLDAGDLTR"
     gene            5511..6119
                     /locus_tag="IE257_RS16215"
                     /old_locus_tag="GCM10010343_33460"
     CDS             5511..6119
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548649.1"
                     /locus_tag="IE257_RS16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33460"
                     /product="response regulator transcription factor"
                     /protein_id="WP_189969113.1"
                     /transl_table=11
                     /translation="MTKVLVLHSVCLVRSALAALLRSEGDFEVTSSGWRAAARQAEFLR
                     PDVAVVDLDCPGVSAALLADAGATRLLPDSSVSLLVLARADRPGSLRRAFLTRARGYVD
                     KDGSPERLVRAIGKVAAGERFIDATLASAFMEADPMPLSPRELSVLARAAEGDSIAEIA
                     HALHLASGTVRNYMAAVTRKTGARNRIDAIRISRRAGWV"
     misc_feature    5640..5642
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6151..7977)
                     /locus_tag="IE257_RS16220"
                     /old_locus_tag="GCM10010343_33470"
     CDS             complement(6151..7977)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956283.1"
                     /locus_tag="IE257_RS16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33470"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189969115.1"
                     /transl_table=11
                     /translation="MSGDGSWRRVSREGRRFLRGRPRPLRRLALWSLLESAHTFLGGYA
                     VARALDDGFLAGRTGTGIGWLAVAAAGALLGALALRGVFGGLADLVEPLRDALVRRAVH
                     RAIERAVADPGRAGDPGAVSRLTQQTEMARDSFAGLVLIARSFVFTALGALLGLAALDP
                     VLLPLVVPALLLGTVAFLATLRPMARVQRAALDADEALAARTGELAAGLRDVVACGGGA
                     SAGARVERLVAAQERLTGRLARWAALRTLSLGVAGRLPVVVLLAATPWLLGRGVSAGAV
                     AGALTYLLQSLLPALDALMTAVGAAGTRLLVVLDRFCDPEPAGTGAGTGAGTHTRTEAG
                     TARTTPVPAQPAQAASAPASAPASASAPAVELHRVRFAYGPRAHPVIDGLDLVVGTGEH
                     LAVVGPSGIGKSTLTALIAGLLPPGRGTVRVAGAPARGAPGYGPGGPDVRRTLLPQQAY
                     VFTGTVRENLTHLCPGPVTGGEVQRAAAALGSDALVARLGGLDAPVDPGRLSPGERQHL
                     ALTAAYLSPAPLLLLDEATCHLDPRAEARAERALAERPGTLVVVAHRISSAARADRVLV
                     LDGTRAVCGTHAELPARSPLYRDLVGMWNAQE"
     gene            complement(7974..9800)
                     /locus_tag="IE257_RS16225"
                     /old_locus_tag="GCM10010343_33480"
     CDS             complement(7974..9800)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569990.1"
                     /locus_tag="IE257_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33480"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189969117.1"
                     /transl_table=11
                     /translation="MTAPDPTGEAAAARGADRALRAAARHSAGRLTAASLCSMAAAGAA
                     LAEPAVLGHTLDLLLRQDPAGARWTGWCAAVIAAEVLLDAATARLSGGVDARSTAWLRR
                     LGLARLLRTAPHHAARHSPGDLSARLTAQATTAGAVPAAAVSAVVALLAPLGSLVALIL
                     VDVWTALAFLAGIPLLALLLRAFARDSGASVSRYQEVQLAMAGRLVEALGGARTIAAAG
                     TAEREQARVLDRLPELGAEGRRTWRIYGATMARTSALMPLLLYVVLGVGGVRLAEGAVG
                     VGGLLAAVRYAGLAAGVGAVTGRLAAVVRGRAAARRTAALFELPELPQGKRRLPGAGPG
                     TLELRGVRVVRAGTVLLRDVDLRIPGGVTAAVVGRSGSGKSTLAAVAGRLTVCDAGLVL
                     LDGVPLDELSGEELRREVGHAFERPALFGEGVADAITFGGGPAPGPEAVRAAARAAGAD
                     AFVRRLPEGYDTALADAPMSGGELQRLGLARAFCRAGRLLVLDDATSSLDTVTAREVER
                     ALARDVRPGTRLVIAHRVSSAARADLVVWLDAGRVRATGTHAELWRDPDYRAVFGEGPE
                     PAGEPAAEAVAEAAVEAVAEAAVEPPGTEAVR"
     gene            complement(9867..10004)
                     /locus_tag="IE257_RS16230"
                     /old_locus_tag="GCM10010343_33490"
     CDS             complement(9867..10004)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="IE257_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33490"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_030389872.1"
                     /transl_table=11
                     /translation="MTLLDLQSMDTPKEETTEAAHGGGGGSRASLLLCGDSSLSITTCN
                     "
     CDS_motif       complement(9942..10004)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTLLDLQSMDTPKEETTEAAH"
                     /locus_tag="IE257_RS16230_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9867..9941)
                     /prepeptide="core"
                     /locus_tag="IE257_RS16230_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="21.10"
                     /molecular_weight="2100.3"
                     /monoisotopic_mass="2099.0"
                     /core_sequence="GGGGGSRASLLLCGDSSLSITTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTLLDLQSMDTPKEETTEAAH"
                     /leader_location="[9941:10004](-)"
                     /alternative_weights="2118.3"
                     /alternative_weights="2136.3"
                     /alternative_weights="2154.4"
                     /alternative_weights="2172.4"
                     /alternative_weights="2190.4"
     gene            complement(10001..12715)
                     /gene="lanKC"
                     /locus_tag="IE257_RS16235"
                     /old_locus_tag="GCM10010343_33500"
     CDS             complement(10001..12715)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992235.1"
                     /locus_tag="IE257_RS16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33500"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_189969119.1"
                     /sec_met_domain="micKC (E-value: 1.2e-236, bitscore: 782.6,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 7.7e-12, bitscore: 40.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.6e-08, bitscore:
                     27.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAAFCDADRWFYDAPYRRAEESYPAALAPVPAGWQTHRSGD
                     WLALRPLDARLPSQGWKIHVSACLDNAESVLERVHRYCVDRRIAFKFVPSRYLLHLRNA
                     KYADRAASGKFLTVYPADEAQCRSIAQELDALLTGEPGPYILSDLRWNDGPVHLRYGSF
                     TLRHCYDDRGELVPAIEAPDGRLVPDARGPVFQPPEWVDLPAFLAPHLDRRAAVTLAGL
                     PYTVERALHFSNGGGVYAGRDVRTGEPVVLKEGRPFAGLAADGADAVTRLHRERMALEQ
                     LAGLDCVPSVHGTFTVGDHHFLVMQHLEGKPLNTYFARRHPLIEADPDPAELAEYTRWA
                     LDVHRRVTEAVRAVHARGIVFNDLHLFNIMVAEDEETGEPSVALLDFEAAAHADENLRQ
                     TVANPAFVAPADRRGFAVDRYALACLRLALFLPLTSLLVMDRAKAAHLADIAARQFPVP
                     RAFLDEAVREILAGAEGADAAGAGASAGAGAGGRGVLLRRPYLPVEPGDGEAARASMTA
                     ALRASATFDREDRLFPGDPAQFAAAGGGTCFGHGAAGVLYALAETGADPWPEAEEWLLA
                     RTKEPASGMPLGFYDGLAGLAWTLERLGHRDRALALAEQLLGQPWESAGPDLHGGLAGI
                     GLALDSLGRTTGEAELGAAALRCADLLAETAGPTSGSGSGSGSGSAGTKRAGLLHGHSG
                     PALLHLRLYERTGDQEFLLRAGRALHRDLDRCVTSVFGTLQVDEGWRTMPYLGGGSVGI
                     GMVLDDWLEHARDDRFERARPEIVRAAQATFYAQPGLFRGAAGMILHLARTTTPGPGSA
                     PEDIARQVEALARHAVPYQGFLAFPGEQMMRLSMDLSTGTAGALLALGSAAPGGRAHLP
                     FLPPPRSAAAAPEPVPLAGAVTHRNTTVKRKRT"
     cand_cluster    10812..31903
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    10812..31903
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[20811:21903](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(20812..21903)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="2"
     misc_feature    12790..12808
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.97"
                     /tool="antismash"
     gene            complement(12842..14116)
                     /locus_tag="IE257_RS16240"
                     /old_locus_tag="GCM10010343_33510"
     CDS             complement(12842..14116)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940846.1"
                     /locus_tag="IE257_RS16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33510"
                     /product="TerD family protein"
                     /protein_id="WP_189969121.1"
                     /transl_table=11
                     /translation="MSLLKGANVPVPSDTVRVELGWRGGPGAPDVDVSALLLTAAGKVR
                     SDDDFVFYNQPVHRSGAVRHEGRRQDGTGAIETIGVALTAVEQEIGTVVLAASTDGTFA
                     QVSGLFVRVLDAQSGAETARFDATGATTETALVLGELYRRGGAWKFRAVGQGYASGLAG
                     LATDFGITVDDPAPPAPAPVVPVALPPAPAPAPAPAPAPAPVVPAPARPVQLSKITLTK
                     AAPAVSLTKQGATTGRMRVNLTWSTAQPPRGWMRKGRDAVRLEDVDLDLSCLWELQNGT
                     KGIVHPINNQFGSFDQPPYVQLDHDDRTGASEAGENLMINLDHAAEIKRLLVFVVVYSG
                     ATGFAGLRGVATLYPPAGPPIEVLLDECTVPSPVAAIALIENVRGELIVRREAKYLLLA
                     PGILKQQAADLEYGWGMGWQPASKD"
     gene            complement(14246..14458)
                     /locus_tag="IE257_RS16245"
                     /old_locus_tag="GCM10010343_33520"
     CDS             complement(14246..14458)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676944.1"
                     /locus_tag="IE257_RS16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33520"
                     /product="hypothetical protein"
                     /protein_id="WP_189969123.1"
                     /transl_table=11
                     /translation="MPTDAVGRFLAVLEPHRREAVTSRSREEQERLAAAWERELASDDE
                     LDTLDELSPPAAEAEAARRVMDREA"
     misc_feature    14571..14585
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.55"
                     /tool="antismash"
     gene            complement(14648..16801)
                     /locus_tag="IE257_RS16250"
                     /old_locus_tag="GCM10010343_33530"
     CDS             complement(14648..16801)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024180.5"
                     /locus_tag="IE257_RS16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33530"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_189969125.1"
                     /transl_table=11
                     /translation="MGTWRSRFESLVVTAVRRHLEVDLVTDLEDVDATDVRAITRLYQV
                     LDRRPVYSVGLDHIVETVDQHYARASPKPLTRRLLASLLDETGGHFEELGRAQEAEQCR
                     RIAAELAPGGPDRTILYLVSAISSRQQLYVLGSLTVDAVLRALLHEVGRSGRRIRRAKI
                     LGAVAYAAHTTGNAERLRVAVEALAAAADTPGYRALVTYYRSRVLIAGGRVDEGLAAER
                     EFSRAAAAIGPKDRAHQLVASALASTTPHDSAMARASEAALRGDHVGASGWYGQSAEEL
                     PAGPFRSAMRLFAEAARVQGGLLPSANALRECLSRLCADDLFAARTVTDVELLLTGLLM
                     RAVDLHEAGHDAEIVAELADFLGEFRGGTAVGRPQDSGAYDTDARADMTLVDFLARTTA
                     PVTPAEITHALPGHHVLWVNVTGAEVGEHCLTVVTLRPSHPVPLVRRTHVSAADGKALA
                     QCLGEDSEDAPAEAVRRISRLFFADVDPDAAGARILVVPDSVTWAMPWNELAPDGAADL
                     TISMSAGAALRTRPAPAVVVPRVIGIFDETELKGSRLEARALEQLAAQGHIRFTRVHSL
                     AELHDALEAAPYDILTVSVHGTQNDGFEYRMLLPDGPSSPAALLRLGLPRVVVLGCCWS
                     AKSTERADTTAAALSCLVAGASQVVGGLWAIDDELAGRLLADTYDRHLRRGVPLPQALR
                     QAHLALPPDLRPGAAGLAFIGRG"
     gene            complement(16812..17207)
                     /locus_tag="IE257_RS16255"
                     /old_locus_tag="GCM10010343_33540"
     CDS             complement(16812..17207)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS16255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_33540"
                     /product="hypothetical protein"
                     /protein_id="WP_189969126.1"
                     /transl_table=11
                     /translation="MSDTIKMSVPGELAELLVAEGHATPTRGRRSSQWGLDGDFITGTA
                     TVIALLQAPQTIAYLAGAIRSLASRRRAGRPDDRARMYVEAIGPHGQIRFDGEATVEEI
                     ERLLQRTILPAQNVDRAALRDTDTDAV"
     gene            17489..17641
                     /locus_tag="IE257_RS16260"
     CDS             17489..17641
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS16260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189969129.1"
                     /transl_table=11
                     /translation="MGRTRSSRQCLQQAAFGMRPTAGVATLVDPAGTALAVAPKTRRTA
                     LHGHG"
     misc_feature    complement(17527..17536)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            17761..19242
                     /locus_tag="IE257_RS16265"
                     /old_locus_tag="GCM10010343_33560"
     CDS             17761..19242
                     /EC_number="6.3.2.13"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057794.1"
                     /locus_tag="IE257_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33560"
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="WP_189969131.1"
                     /transl_table=11
                     /translation="MKLSALLAGQEHHVLQGDPDTTLITAGTTFDADRVTPGSLFIAVP
                     GHREGGPGAVSPALARGAAAVLVDGREPDLPAAAWPPGTCTVRVPDTRTAAAVVSSRYF
                     GEPGRHMDMVAITGTNGKTSVSYMVESVLRIAEGSSVGVIGTAGSRIGDEPIPMPPSVL
                     TTPESPDLQYLLGCMRDRGAAGVVLEATSMALLTHRIDRTFIDVGVFTNLTQDHLDDHG
                     TMADYRDAKLRLFQGLCRRAVVNVDDPVGAGIVSMMPGAVTTYALDRPADYRATDLVVT
                     ASGTRFTLHHDGRAYPASIPVPGRFSVANALATVAACHVLGHELGALVDALDRMPPVPG
                     RLERFRTPLGTSVIVDYAHSPDSLDKVLTTIRGFARGRVITVFGCGGDRDTSKRVEMGR
                     IAGTHSDLCVLTSDNPRNEDPEAILDQVAPGLTATGTPFRRYADRRRAIAFALSAAGPD
                     DTVLIAGKGSEPHQIVGEKLLPFSDMATVRELAQI"
     gene            complement(19239..19937)
                     /locus_tag="IE257_RS16270"
                     /old_locus_tag="GCM10010343_33570"
     CDS             complement(19239..19937)
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010476397.1"
                     /locus_tag="IE257_RS16270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33570"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_189969133.1"
                     /transl_table=11
                     /translation="MPEQPQEPRRTPLSRDRVLRAAVAFADGSGIEALSMRRLAQELGV
                     VPMALYKHVASKEELLDGMVEVVVAGIGGRAPGSDWKSAVRGRILGARGALLAHTWAAQ
                     VIRSRSGPTPAVLAYLDSVIAMFRAGGFSLDLTHHVMHALGSRVLGFTEELFDDPASTA
                     PQDERAQAAAYEEMARRYPHVTELARSVAHDRGSVIGPGCDDAFEFAFALDLLLDGFER
                     LHAQGWNSTP"
     misc_feature    complement(19997..20015)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.17"
                     /tool="antismash"
     gene            20074..20805
                     /locus_tag="IE257_RS16275"
                     /old_locus_tag="GCM10010343_33580"
     CDS             20074..20805
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981927.1"
                     /locus_tag="IE257_RS16275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33580"
                     /product="DUF4386 domain-containing protein"
                     /protein_id="WP_189969135.1"
                     /transl_table=11
                     /translation="MSSTRRTAVVAGVLFLVTEVAAIGGLALYRPVLHDAAYVIGPGAD
                     TRVFLGALCEFVLALAVTGTGAVLYPVLRKRNEGAAVGYVCGRLLEAAVIVMGIIGVLS
                     VVTLRRQAEGAAGADGASLVTAGRALVAFHDWTFLFGPNFVLGANTLVLAALMYTARLV
                     PRYIAVLGLVGGAMICASATAVLFGIYEQVSVAGSLAALPVFAWEVTLAVRLLRKGFDE
                     GADEGAGTFADERVGEGARVG"
     gene            complement(20812..21903)
                     /locus_tag="IE257_RS16280"
                     /old_locus_tag="GCM10010343_33590"
     CDS             complement(20812..21903)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959586.1"
                     /locus_tag="IE257_RS16280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33590"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189969137.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2e-34, bitscore:
                     113.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHANVTAALERAALHRTRFDSRFEQYFDGLGERFDVPVPSRYVPR
                     CLELLREFSMRGGKRLRVVLLYEAARLVTTDEVPGLAEAALSIELLQTHGLVHDDIIDD
                     APLRRGGPSTYYAYRREFPDHGATALGLAILAGDLAAFLSTQVLLEAEAPAELRQALLA
                     VHTRTAAETVAGQLADLERDSHALPDEEFLHTVTDFKSARYSILAPLTMGLLAAGGDPA
                     PHRARLHRYARLVGIGEQMRDDFLDLFGPFGDDPADEAKSTGADIRSGRRTYAVRALLA
                     AATGAEAALVEAALGDPDCPQATLGRIREIARGAGVDRRLKAEIRRYAEEASAEAASWG
                     PYWREEAVEFFRSLPLWHVARMS"
     misc_feature    21901..21916
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    complement(21903..21916)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.59"
                     /tool="antismash"
     misc_feature    complement(22110..22124)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            <22132..22422
                     /locus_tag="IE257_RS16285"
                     /pseudo=""
     CDS             <22132..22422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056984.1"
                     /locus_tag="IE257_RS16285"
                     /note="Catalyzes the reversible hydration of unsaturated
                     fatty acyl-CoA to beta-hydroxyacyl-CoA; incomplete; partial
                     in the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="enoyl-CoA hydratase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RPVGATEAHGIGLANRLVPTGRSRTAAEELAREIAGFPQICLRHD
                     RLSVLEQHGLPEAEALAGEHRHGLVPLEAGETQAGAGRFASGAGRHGSFGQ"
     misc_feature    complement(22482..22497)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    22483..22496
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            22600..23115
                     /locus_tag="IE257_RS16290"
                     /old_locus_tag="GCM10010343_33600"
     CDS             22600..23115
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020665570.1"
                     /locus_tag="IE257_RS16290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33600"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_229920399.1"
                     /transl_table=11
                     /translation="MARGDRAAFEELYRRTSPWLAVRLRRRCADQQIVAEVMQETYLAV
                     WRAAGSFAGTGSGSGTGGTAVGWLWTIAARRLVDAFRRRAHHAQPPPAAAPYPVAPAAE
                     EEALVATVGGDVGDALRRLAPELRDVLQAMVLDGLSVRETAVLLGLPEGTVKTRARRAR
                     TAMREALA"
     misc_feature    complement(22617..22626)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            23112..23945
                     /locus_tag="IE257_RS16295"
                     /old_locus_tag="GCM10010343_33610"
     CDS             23112..23945
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475065.1"
                     /locus_tag="IE257_RS16295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33610"
                     /product="zf-HC2 domain-containing protein"
                     /protein_id="WP_189969141.1"
                     /transl_table=11
                     /translation="MNVEHASARLIDGYARGGTDLAADELWALEAHLEGCRVCRDRLSD
                     AVTAGAPAVAALTEAVWSDLEHHIATAPQAPPRRLLARLSAWTTPAMTPWLAMVLAVTL
                     LALLLDLTGPGSGVGSGSGRVSLMLLLAPVLPVCGVAASWSRALDPAYELTSSTPRAGL
                     QLVLRRTASVLAVVIPALLAGGWATGVTAAQWLLPCLAFTSATLALGGVIGVSRAAAVL
                     VAAWAAVVVAPTLATSRTAVALGTDGMPVWGAVLALGVAVVIVRRGAYTTPGAHR"
     gene            23969..24778
                     /locus_tag="IE257_RS16300"
                     /old_locus_tag="GCM10010343_33620"
     CDS             23969..24778
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471716.1"
                     /locus_tag="IE257_RS16300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33620"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_189969142.1"
                     /transl_table=11
                     /translation="MKPTVSRADLAPTAYAWQIRATGLKVRAGRKRMAVDGLDLSLGTG
                     VHGLLGPNGAGKTTLIRALATVLRPAGGELELLGQAVGALGEHRALRRRIGYLPQEFGY
                     YKRFTVREFVEYMAWLKEVPTADIPGAVQRAVERVGLADRADERMKALSGGMVRRAGIA
                     QAIVNDPAVLLLDEPTVGLDPAQRLRLRELLQELGTDTCVVVSTHLVEDVAAACTDVVL
                     FAEGRLVFQGTPGELAAAGGPEHDGDSPLERGYSALLVDPARTRGAW"
     misc_feature    complement(23970..23984)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     gene            24775..26157
                     /locus_tag="IE257_RS16305"
                     /old_locus_tag="GCM10010343_33630"
     CDS             24775..26157
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005475061.1"
                     /locus_tag="IE257_RS16305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33630"
                     /product="hypothetical protein"
                     /protein_id="WP_189969144.1"
                     /transl_table=11
                     /translation="MNLRILGIELRRSVAPWAGIVVLATALAFLYLVPGPWWRGTALWT
                     AQWTSMALWTRYPLVFLWPLAVGLGALQGLRDHRSKMSELLISTPRPARHRAAALAGTT
                     AFALVSSFALLVVLGAVRVLAGDATYTHLGWLPISLVGALALTAGAVLGMGIARTVPSA
                     LTPPALAVGAFLLTSLLRQTSDAATPTSAVPNRLSLLSPAVAEARETLLTLSAPVHLGQ
                     TIWLLGMAVTGFVLLAAATPRARLLALTPLLAGAAVALLQFPADPRATYVVDREAATLV
                     CEGPVCVTTAQRARMEDLEAPGAEALRLLRETLGDRAPVGLRETTVPRALGDTPERSRA
                     YVLVDFDDAAIGDAEGEELTRALVGQGIAPLCRPRSDTESGTLEEAVAQSIAAAWVLGE
                     LRPLEGTMHDPSEQAAVADPVWKQFMALPRAEQRQGITALHAAAVSCSGDPLGALTGGA
                     SR"
     gene            26154..26729
                     /locus_tag="IE257_RS16310"
                     /old_locus_tag="GCM10010343_33640"
     CDS             26154..26729
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127133.1"
                     /locus_tag="IE257_RS16310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33640"
                     /product="hypothetical protein"
                     /protein_id="WP_189969146.1"
                     /transl_table=11
                     /translation="MRWLTLYARSRRAPASLAAVLISAVAVGALARIGGGGPVDPRLST
                     LALAAGATALAVGLGGQDLALDRTAAIRWVPRRAVHVLLCGMLIGAVLLAVQTMEGQPA
                     STALVVRNSAGLMGLVALGAAWCGGPYAWIPPFASLSLSFVVPPAPDPATQVLTWMLLP
                     PGTTAGVWTALVLAVAGTTAYAVAGPRR"
     gene            complement(26926..27279)
                     /locus_tag="IE257_RS16315"
                     /old_locus_tag="GCM10010343_33650"
     CDS             complement(26926..27279)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133743.1"
                     /locus_tag="IE257_RS16315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33650"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_189969148.1"
                     /transl_table=11
                     /translation="MTDMNGIDPSTPPTGTGCVECDELGGWWFHLRRCAQCGHIGCCDS
                     SPAQHATAHWKSTGHPLVQSFEPGEEWFWNYDTDALYDSGPRLTPPSDRPADQPTPGPA
                     DRVPEDWTRRLHR"
     gene            complement(27276..28784)
                     /locus_tag="IE257_RS16320"
                     /old_locus_tag="GCM10010343_33660"
     CDS             complement(27276..28784)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578009.1"
                     /locus_tag="IE257_RS16320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33660"
                     /product="ATP-binding protein"
                     /protein_id="WP_229920400.1"
                     /transl_table=11
                     /translation="MSGQVMPCSPQEIGSLFLFEKLTPEQLGRLCAEGRVERFEAGPVY
                     TEGSPATCFYVMIEGTVVLFRRVGGDDVEVSRTSQRGVYAGAMQAYLGDQVPQTYTNSM
                     RVTEPTRFFVLPAQSFADIMQEWFPMAAHLLEGLFFGSKNTQRAIGQRERLLALGSLSA
                     GLTHELNNPAAAAVRATATLRERVGKMRHKLAHISQGQYSREVIADLIEMQERTVERVA
                     KATALSPLEASDREDELADWLDDHDIAEGWRIAPVFVQAGLDTDWLDQVAAAVAEEILP
                     SAIGWLNYTVETELLMDEIDDSTTRISHLVDAAKQYSQLDRAPYRVVDVHELLDSTLLM
                     LSGKIGSRVRVVKDYDRSLPDVPAYPAELNQVWTNLVDNAVFAIGSTGGEGTLTVRTAR
                     EGDRLMVEFRDTGPGIPADIRSRIFDPFFTTKPVGEGTGLGLDISWRIIVNKHHGSLQV
                     ESAPGDTRFQVLLPLTAPDPANETAATETAASEIAATATAEEPA"
     gene            complement(28781..30457)
                     /locus_tag="IE257_RS16325"
                     /old_locus_tag="GCM10010343_33670"
     CDS             complement(28781..30457)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033203.1"
                     /locus_tag="IE257_RS16325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33670"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_189969151.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-29, bitscore:
                     98.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQAADAARTVILTVDDDPGVSRAIARDLRRRYGAEYRIVRAESG
                     DSAMEALRELKLRGDLVAVILADYRMPQMNGIEFLEQALQVYPGARRVLLTAYADTNAA
                     IDAINVVDLDHYLLKPWDPPEEKLYPVLDDLLTAWRTSDYRPVPATKVVGHRWSARSSD
                     VREFLARNQVPYRWYSSDEPEGQRLLEAAGADGQRLPLVITPEGTALIEPEAPELAAHV
                     GLATTPTAEFYDLVVIGGGPAGLGSAVYGASEGLRTVLVERSATGGQAGQSSRIENYLG
                     FPDGVSGAQLTDRARRQAGRFGAEILTAREVTGLEVNGAARVVHFSDGSAIAAHSVILA
                     TGVSYRQLHAPGCDQLTGCGVYYGSSLTEATSCQGQDVYIVGGANSAGQAAMYLARGAK
                     SVTLLVRGESLAASMSYYLIQQIQEMPNITVRTRTVVEAAHGDGHLEQLTLRDVDSGAT
                     ELVDAQWMFVFIGAAPLTDWLDGTVLRDQHGFILAGPDLTPDGRPPAEWELDRPPYHLE
                     TNIPGVFVAGDARAQSAKRVASAVGEGAMAVMLVHRYLEQS"
     gene            complement(30664..31407)
                     /locus_tag="IE257_RS16330"
                     /old_locus_tag="GCM10010343_33680"
     CDS             complement(30664..31407)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962163.1"
                     /locus_tag="IE257_RS16330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_33680"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189969154.1"
                     /transl_table=11
                     /translation="MRDHQEQEPATVATAVREGDGSPIVVVDDVHHSFGSGPQAVHALR
                     GVSFEVRRGELTALRGRSGSGKTTLLNLVGGLDTPTGGRITLDGTDLADLDEPGLLALR
                     RDRIGFVFQSFGLIPVLTAAENVGVPMRLRRVPARIREERARTLLALVGLADHAEQRPG
                     ELSGGQQQRVAVARALANDPDLIIADEPTGQLDSETGRSVMELLRAVVRSESVTILVAT
                     HDPNLIELADRVVELRDGRIVDTGA"
ORIGIN
        1 tgccgggaac gtcgatcttg taggcgccgg gttggcagtt cagggcggcg cgcggggcgg
       61 gcttggcggc ctgggtggcc ttcatgctct gggcggccct ggctgctgtt tcggcgttgt
      121 cggcgtcgtg cttggcctgg tcggccttgg ccgaggggac gggacctgcc gggcgtatcg
      181 cggtggcggc gggggagccg cagtccaaca ggccctgggc cttggccatg atgctgtcgg
      241 cggggacctt gtcctcgcag cgcaccgcgc cttcttccag tgcggtgtag gtggtgtagc
      301 tgccggtgtc ggccccttcg atccacttca gcgcccaact gccgtcgttc tgctggacgc
      361 ggttgcagtt gaggctgccg taggtgccgg tgaccttctt ggtgcccttg tacacgccgt
      421 agtagccggg ctggaagaag ctccagttca ccgtgtcgga cacgctggac gtggaggagt
      481 agtcgacctg cacgttcagg cccagagtcg cgcccacgct gccgagggcc tcgacggcga
      541 agctgccctg aatgttggcg ttgaggccta ccgagaccga gatggtggtc tgcgtgctgg
      601 tggtgacgga gtggcttccg gtcgtgccct gggtgacgta ccagcccttg aagtgggtga
      661 ccgtgggggc gacttcggtg gtcttgatga aggggtggcg cttgccgagg tcggccgccg
      721 tgcatgcctg cccggcggcg acggtcgagg ccgcggtggt ggtggccggt tgggcggtgg
      781 ccggttgggc ggcggtgagg cccatagtgg tgagtgcggc ggtggcgctc acgacggcgg
      841 tgatggatcc gcgtatacgg ccaacttggc ttttgcgacg cattgttgtc ttccccctgc
      901 ttttccggct cggtcgggtc ggtggtcggt cgctcgggcc cggccgacgg tagctcaccg
      961 acggggcgag gcgggagatc agaatgagcc ggaaacgatc actaggggct cttaccgccc
     1021 ttcggtgcgg gctgtagcgt gcggcttcga tccccgattg ggccagggca tgtcaactcg
     1081 acctgaagga acgctcgttg aagcgcgtga gatcactcct ggcggtgctt gcctcactcg
     1141 cactgaccgc gacgctgata gccctgaccg gctcaccggc cgtcgccgcc cctgccacga
     1201 gccgggcggc cccccagggc cacggcacgt gcgcggcgac cgcgcccggc tccaagtccc
     1261 agcggcgggg catggtgtgg tcctgcccag aggtaggacc cgcccccgcg tgggtcgcct
     1321 cccgcatgac ccacaaggcc gccccggcta cgtccacggc ccgggccgcc ggccccggcg
     1381 gcggccaaca cgacggccgc accccggaag agctctgcgc cgatgcctcc cccgccgcgg
     1441 tcgtctccaa ccgcctcgcc tactgcgtac gcggcgcagc cagatacacg cgcctcggtg
     1501 cggacaacaa ggtcgagggc gaagccatcg tggggatcct catcagctcc ggcatcaagg
     1561 agaccccgaa cgcggcctgg caggagaaag tccacgtcgt ggccctcaag atggagaaca
     1621 tgcctgacgg tgtgtcgata gccgtcagtt ccacctgcag cggcatatgc actacgcagg
     1681 gacccgcctg gggcggttcg gccgtggtac tacgcgaaga cggcgagggc aggagcgacg
     1741 gggtactcgg ctacagctct cctgtcggca agggcagcaa ggcgccgcat atccggccct
     1801 cttaccactt ggtcggcaga atcctcggcg gcggcatacc ccaacccccg gtcaacgcgg
     1861 accatcccgg cccctccctg cgctgtgacg accaggtcac cagatggccc ggctgcatcg
     1921 tggaagggca cagcatcctc gaccgtgagc ccgtccaggt gatcatcgct gactgaccgt
     1981 ccgcagcgtg tcccgcgacc tgggccgatg ccagcgatct ttccggcggg caggcccaac
     2041 gtttcccggg aagtacggct tcagcccggc ccactccgcg tcactgagaa ctttccgtcc
     2101 cacatgcctg ggaacgagtt ctcgtctcgg ttcgtcaccg acccatcagg caggccctag
     2161 tcaagttcga aggggtgcgg gtcgggtgcc agcgggtggc gtatgacgcc cttgaacaga
     2221 tcgagcacac gctcgtgcac gtcgcccacg cggtcgacca cccgcacccg gaccagcacc
     2281 gtctcgatct cggacaacgc gcgctcggcg aaccaggcca ggaacatgat tccctgaccg
     2341 ggaatcggcc ggccggcccc gatcaggtcg agccacaggt cctcgcgatc gaccagtccc
     2401 cgcgcgacgc aggccctgat ggcgtcatcc ctgttcaacc aggacgaggg accctcgtcg
     2461 gggtctgcat gtcggctccc cctgtcggca cacaggggtc ctgcccgact cggcaccgga
     2521 gtacgcgcgc cccgtccggc tcagccgccg atgtcccggc tgtggaagtc cgccagggtc
     2581 tcgcgccgca tgaggaggcg ggcccggccg ttgtcgaccg cgacgaccgg cgggcggccg
     2641 accatgttgt agccggaggc catggacacc tggtacgcgc ccgccaccgg tagggcgagc
     2701 aggtcgccgg ggtggacgtc cccgggcagt tccacgtcgg cggccaggat gtcgcccgcc
     2761 tcgcagtgcc tgccgaccac cgtcgccacg cacggcgcgg tgggggagcg gcggccgacg
     2821 aggcggggcg cgtagcgcac cccgtacagg gccggccggg ggttgtcgct catgccgccg
     2881 tccacggcga cgaacacgcg gccgccggtg cgcttcacgg cgaggacgcg gtacagggcg
     2941 acccccgccg gaccggcgac cgcgcggccg ggctcgatcg ccagccgtgg gacggcgagc
     3001 cccgccgccg cacagctctc gatcagctcg gtacggagtc tgcgggccag ggcggcgacg
     3061 tccagcgacg ggtcgcccgg acggtacgcg atgccgtggc cgccgcccat gtccagctcg
     3121 ggcaggacga cgccgtgggc gtcgcggacg cgggccatca gtcccaccat gcggcgcgcg
     3181 gcggcgaggt acggtctgac ctcggtgatc tgggagccga tgtggcagtg gagcccggtc
     3241 agttcgagct ccggccgccc caggatccgg gcgatggcgt gctgggcgga accgtcggac
     3301 agggccagac cgaacttctg gccgtcggcg ccggtacgga tcttctcgtg gccgccggcc
     3361 atgatgccgg gcaccacccg gaccatcacc ttctgcggac cgcccgttcc caccgctgcg
     3421 gccagccggg cgatctcgga cgggctgtcg atgacgatcc ggcccacccc gagccgtagc
     3481 gccgcctcga tgtcgcgcgg ggatttgacg ttcccgtgca aggcgatgcg gtccggcggg
     3541 aagcccgcgg tgacggcgag ttcgagctcg cccgccgagc agacgtccag cccgaggccc
     3601 tcctcgtcga cccagcggac catggcccgg gacaggaagg ccttggcggc gtacagcacg
     3661 tcggcgtcgg ggaaggcgtc ccggtagctg cggcaacggg cccgtacctc gccctcgtcc
     3721 agcacgtaca cgggggtttc gaagcggtcg gcgatctcgg cgagcgacac ccctccgacg
     3781 gcgagcccgc cgtgcggcag gccgtgtgcg gaggccggcc agacggacag gtcgtccgtg
     3841 cccgcggtgg cttcggacag tgcggcagtg gtcatgaagt tccccctcgg gcgaggcgga
     3901 ccgggaaccg gtccggccgc tgagtcgccg tggtcgccct ggtcgccgcc ccggtcgccg
     3961 cgggagccga cagtgtcgga tcgacggtga tcagctccgc gccgagcggc tcgcacagct
     4021 cgcgcagcag ggactcggac agccggatgt acccctgacc cccaccgagg gtcgcagcca
     4081 gccgctccgg gcgggtgaaa ccgacggccg tacgtacccc cagtggggtg cggaacagcc
     4141 ggaccaccgc cccggcgccg gttcccggcc ggacgggcac gtacagcagc ccggccgggg
     4201 tccgttcttc gggctcgggg tcgtcttcgt actggaacag gcacatgggc tctccctggg
     4261 gaaccgcgaa cgatgggtga gccccgggcg gcgcggggag gcggtccggg gcacgtgatc
     4321 gaagctatcc ccgcccgggg gccctccgcg tgacgtcctg acgccacctt gacggacatc
     4381 ggccgactcc atacacatcg ctgacggagg ccgggccgtg gcatcaggaa cccgtacggg
     4441 tttcccgttc cggcgtcaga agcgcgtcag cggtgcgtcc ggccggaccg ccaccgctgt
     4501 ttcatggacg gcgagagccg acacaggagc agaggggcgg gcgagcgtgc gaggaagagt
     4561 ggtggcgggg tcctgcggtt ccctcggaag cctgacggcc ctgcaccggg cggccgccga
     4621 ggcccgggcg cgggacgcgg agctgtgggt cgtactcgcc tggcagccgc cgatcggcgg
     4681 accgggttcc aggggctcca ccggcggtac gccgctgctc gccggttgtc gcgacgccgc
     4741 ggtcgagcgg ctgcgaggga tcctcgacac cgccttcggc gcgagcccgc cgggcgtgca
     4801 cctggccggg ctgacggtcc gggccacccc gggtgcggcg ctggtggaca ccgtccgcga
     4861 ccccggtgac ctgctcgtcg tcggtacggg ctcacgcgcc cccctgctcc gcgcgctgcg
     4921 cccgtcggtg gcgcgctact gcctggccca cgccccctgc ccggtcctcg ccgtgccgcc
     4981 cagcccgctc caggccgacc tggacgccgt gcaccggcgc aatgtgtggc gccggccgct
     5041 ggacgccggg gacctgaccc ggtgaacgcc ccgccccggc ggcccctcgt acgggacagg
     5101 ggcctagaag cggctcgccc ggtgacgggc gcggcggttg ccgccgcggt ggacgagcag
     5161 cagggccagc accatgggtg cgatcaggag ggtcatcgtg gtcatggaag tgcactcctc
     5221 tcctcgtggt ccgttctccc gcacgtgtgg ccgccgagag gtatccgaaa cccccggatc
     5281 accccgatgc gcgcggaatc agcccatccg gatatcggcg tcccgcccgg ctccacggcg
     5341 cttcccggac ccctgccgag gtgagagggc cacaagccgc ccaggggtgg cactggagga
     5401 gcgcccgggt caggccatgc gcccccgcac gcctcccgcg gagacgttcc cgcacggtgg
     5461 tagctgggca gccgcttggt gctgatcgat cgtcacgtga ggggaagccg atgaccaagg
     5521 tcctggtgct gcacagcgtg tgcctcgtga ggtccgctct ggccgcgttg ctgagatccg
     5581 aaggcgactt cgaagtcacc tcctccggct ggcgggccgc cgcacgccag gcggagttct
     5641 tacgacccga cgtggcggtc gtggacctcg actgtccggg ggtctcggcc gcactcctcg
     5701 cggacgccgg ggccacccgc ctgctgcccg actcgtccgt gtccctgctc gtgctcgccc
     5761 gggccgacag gcccggctcg ctgcggcgcg ccttcctgac acgggcgcgc ggctacgtcg
     5821 acaaggacgg ttcgcccgag cggctggtcc gggccatcgg caaggtcgcg gcgggcgaac
     5881 ggttcatcga cgccacactc gcgtcggcct tcatggaggc cgatcccatg ccgctcagcc
     5941 cccgcgagct gagcgttctg gcgcgggccg ccgaggggga ctcgatcgcg gagatcgcgc
     6001 acgccctgca cctcgccagt gggaccgtac gcaactacat ggccgccgtg acccggaaga
     6061 ccggcgcccg caaccggatc gacgccatcc ggatatcccg gcgggccggc tgggtctgag
     6121 cccccggacc gggtttcccc ggatcccgcc tcattcttgt gcgttccaca tacccaccag
     6181 atcccggtac aggggcgacc tggccgggag ttccgcatgc gtgccgcaca ccgcccgggt
     6241 cccgtcgagt acgaggaccc ggtcggccct ggcggcggag gagatgcggt gggcgaccac
     6301 caccagggtg ccggggcgct cggcgagcgc ccgctcggcg cgcgcctcgg cccgggggtc
     6361 gaggtgacag gtggcctcgt ccagcagcaa caggggggcg ggggagaggt aggcggcggt
     6421 gagggcgagg tgctgccgct cgcccgggga gagccggccc gggtcgacgg gcgcgtccag
     6481 tccgccgagc cgggccacga gcgcgtcgga gccgagggcg gccgcggccc gctgcacctc
     6541 gcccccggtc accgggccgg ggcacagatg ggtcaggttc tcgcggaccg tgccggtgaa
     6601 gacgtacgcc tgctggggca gcagcgtccg gcgcacgtcg gggccgccgg ggccgtaccc
     6661 cggggcgccc cgggcggggg cgcccgccac ccgaacggtg ccccggccgg gcggcagcag
     6721 gccggcgatc agggctgtga gggtggactt gccgatcccg ctcggcccca ccacggccag
     6781 gtgttcgccc gtcccgacca ccaggtcgag gccgtcgatc accgggtggg cgcgggggcc
     6841 gtaggcgaag cggacccgat gcagttcgac ggcgggtgcg gacgcggacg cgggtgcgga
     6901 cgcgggtgcg gacgcggcct gcgccggctg cgcggggacc ggggtcgtcc gcgcagtgcc
     6961 cgcctccgtc cgcgtatgcg tccccgcccc cgtccccgcc cccgtccccg ccggttccgg
     7021 atcgcagaac cggtccagca ccaccagcag ccgggtaccc gccgcgccca ccgccgtcat
     7081 cagcgcgtcc agggcgggga gcagcgactg caggaggtag gtgagggccc cggccaccgc
     7141 ccccgcactc accccgcgcc cgagcagcca cggcgtcgcg gccagcagca cgacgaccgg
     7201 cagccggccc gcgacgccca gggacagggt gcgcagggcc gcccaccggg cgaggcgccc
     7261 ggtcagccgt tcctgcgcgg cgaccagccg ttccacccgg gcgccggcgc tcgccccacc
     7321 accgcacgcg accacgtcgc gcagccccgc cgccagttcg ccggtgcgcg cggcgagcgc
     7381 ctcgtcggcg tccagcgccg cacgctgcac gcgtgccatc gggcgcagcg tggccaggaa
     7441 tgcgaccgta cccaggagca gggcgggtac cacgaggggc agcagaacgg gatccagcgc
     7501 cgccaggccg agcagcgctc ccaaggcggt gaagacgaac gaccgggcga tcagcaccag
     7561 tccggcgaag gagtcccggg ccatctcggt ctgctgcgtg agccgggaga ccgcgcccgg
     7621 gtcaccggcc cgcccgggat cggcgacagc ccgctcgatc gcccggtgca cggcgcgccg
     7681 cacgagagcg tcccgcagcg gttcgaccag gtccgcgagc ccgccgaaca ccccgcgcag
     7741 cgccagggcg cccaggaggg cgcccgcagc ggccacggcc agccagccga tgccggttcc
     7801 ggtacggccc gccaggaagc cgtcgtcgag ggcgcgggcc acggcgtacc cgccgaggaa
     7861 ggtgtgcgcg gactccagca gggaccagag tgcgagccgg cgcagcggcc ggggccgccc
     7921 gcgcaggaag cggcggccct cgcgggacac cctgcgccag gaaccgtccc cgctcaccgg
     7981 accgcctccg tgccgggcgg ttccacggcc gcttccgcaa ccgcttccac ggccgcttcc
     8041 gcaaccgctt ccgcggccgg ttctccggcc ggctccggcc cctcgccgaa cactgcccgg
     8101 tagtcgggat cccgccacag ctccgcgtgc gtaccggtcg cccggacccg ccccgcgtcg
     8161 agccatacga cgaggtccgc gcgggctgcc gaggagacgc ggtgggcgat gacgagacgg
     8221 gtgcccggcc ggacgtcccg ggccagggcc cgctccacct cccgggcggt gacggtgtcc
     8281 aggctcgacg tcgcgtcgtc cagcaccagc agccgcccgg cacggcagaa cgccctcgcc
     8341 aggccgaggc gttgcagctc gccaccggac atcggggcgt ccgccagcgc ggtgtcgtac
     8401 ccctcgggca ggcggcggac gaaggcgtcg gccccggccg cccgagcggc ggcgcgcacg
     8461 gcctccgggc ccggcgccgg cccgccgccg aacgtgatgg catcggcgac gccctccccg
     8521 aacagggccg gtcgttcgaa ggcgtggccg acctcgcggc gcagctcctc gccggacagc
     8581 tcgtccagcg gcacgccgtc cagcaggacg aggcccgcgt cgcacacggt gagccgcccc
     8641 gcgacggcgg ccagcgtcga cttgccggag cccgaccggc cgacgacggc ggcggtcacg
     8701 ccgccgggga tccgcaggtc cacgtcgcgc agcagcaccg tgcccgcgcg cacgacccgt
     8761 accccgcgca gctccagcgt ccccggcccg gctccgggca atcggcgctt gccctgcggg
     8821 agttcgggca gctcgaagag ggccgccgtc cggcgggcgg cggcccggcc gcgcaccacg
     8881 gccgccagcc gccccgtcac ggcgccgacg ccggccgcga ggcccgcgta gcgcaccgcg
     8941 gccaggagcc cgcccacccc gacggccccc tccgcgaggc ggaccccgcc cacgccgagg
     9001 acgacgtaca gcagcagggg catgagggcg ctcgtccggg ccatggtcgc cccgtagatc
     9061 cgccacgtgc gccgcccctc ggcgccgagc tccggcaacc ggtccagcac gcgcgcctgt
     9121 tcgcgttcgg cggtgcccgc ggccgcgatg gtacgggcgc ccccgagggc ctccacgagg
     9181 cggccggcca tggcgagctg cacctcctgg tagcggctga cgctggcgcc cgagtcgcgg
     9241 gcgaacgccc tcagcagcag cgcgagcaac gggatcccgg cgaggaaggc cagcgcggtc
     9301 cacacgtcga ccaggatcag cgccacgagt gagccgagcg gggcgagcag ggccacgacc
     9361 gcgctcacgg cggccgccgg tacggcgccg gcagtggtgg cctgcgcggt cagccgggcg
     9421 gagaggtcac cgggggagtg gcgggcggcg tggtgcggcg cggtgcgcag caaccgggcc
     9481 agtcccaggc gccgcaacca agcggtggag cgggcgtcga cgccgccgga gagccgggcc
     9541 gtcgccgcgt ccagcagcac ctcggcggcg atcaccgccg cgcaccaccc ggtccagcgg
     9601 gcgccggccg ggtcctgtcg cagcagcagg tcgagggtgt ggccgaggac cgccggttcg
     9661 gccagggcag cgccggcggc ggccatcgag cagagggaag cggcggtgag gcggcctgcg
     9721 ctgtgccgcg cggccgcccg cagagcccgg tcggcgccgc gggcggccgc cgcctcgccg
     9781 gtgggatcgg gcgcagtcat gggcgcaggc tccaggggtg tgatgcgggc ccgggcggcg
     9841 aaccgcccgg gcccgggagg acctgatcag ttacaggtcg tgatgctcag gctgctgtca
     9901 ccgcagagga gcaggctggc gcggctgccg ccacccccac cgtgcgcggc ctcggtggtc
     9961 tcttccttcg gggtgtccat cgactgcagg tcgagaagcg tcatgtccgt ttcctcttca
    10021 ctgtggtgtt ccgatgggtc acggcccccg cgagggggac cggctctggg gccgccgcgg
    10081 ccgaccgcgg cggcgggagg aacggcaggt gcgcgcgccc gccgggcgcg gcgctgccga
    10141 gggcgaggag agcgccggcc gtgcccgtgg acaggtccat ggacaggcgc atcatctgct
    10201 cgccggggaa ggccaggaag ccttggtacg ggaccgcgtg gcgggccagg gcctccacct
    10261 gccgggcgat gtcctccggg gcggagcccg ggcccggcgt cgtggtccgc gccaggtgca
    10321 ggatcatgcc ggccgcgcct cggaacagac cgggctgcgc gtagaaggtc gcctgggcgg
    10381 cgcggacgat ctccggccgg gcccgttcga agcggtcgtc ccgtgcgtgc tccagccagt
    10441 cgtccagcac catgccgatc cccacgctgc cgccgccgag gtagggcatc gtgcgccatc
    10501 cctcgtcgac ctgcagggtg ccgaagacgc tggtcacgca gcggtcgaga tcgcggtgca
    10561 gcgcccggcc ggcccggagc aggaactcct ggtcgccggt gcgctcgtag agccgcaggt
    10621 ggagcagtgc gggtccgctg tgaccgtgga gcagaccggc ccgtttcgtc ccggcggagc
    10681 cggagccgga gccggagccg gagccggagg tcggacccgc ggtctccgcg aggaggtcgg
    10741 cgcagcgcag ggcggcggcg ccgagctccg cctcgccggt ggtccggccc agggagtcca
    10801 gggccagccc gatgccggcg agtccgccgt gcaggtcggg tccggccgac tcccacggct
    10861 ggcccagcag ttgctcggcg agcgcgagcg cgcggtcccg gtgccccaga cgctccaggg
    10921 tccatgcgag accggcgaga ccgtcgtaga agcccagcgg cataccggag gccggctcct
    10981 tcgtccgggc cagcagccac tcctcggcct cgggccacgg gtcggcgccg gtctcggcca
    11041 gcgcgtacag cacaccggcc gctccgtggc cgaaacaggt tccgccgccc gcggccgcga
    11101 actgggccgg atccccggga aagaggcggt cctcgcggtc gaaggtggcg ctcgcccgca
    11161 gcgcggccgt catcgaggca cgggcggctt ccccgtcgcc cggctcgacg ggcaggtagg
    11221 ggcggcggag cagcacccca cgacccccgg caccggcacc ggcgctggcc ccggcaccgg
    11281 ccgcgtcggc cccttcggca ccggcgagga tctcccgtac cgcctcgtcc aggaacgcac
    11341 ggggtacggg gaactgccgg gcggcgatgt ccgcgaggtg cgccgccttc gcccggtcca
    11401 tcaccagcag gctggtcagc ggcaggaaca gggccaggcg cagacaggcc agggcgtacc
    11461 ggtcgacggc gaatccgcgc cggtcggccg gggcgacgaa cgccgggttg gcgaccgtct
    11521 ggcggaggtt ctcgtcggcg tgggcggcgg cctcgaagtc gagcagtgcg accgacggtt
    11581 cgccggtctc ctcgtcctcc gcgaccatga tgttgaacag gtgcaggtcg ttgaagacga
    11641 tgccgcgggc gtgcaccgcc cggacggcct ccgtcacccg ccggtggacg tccagcgccc
    11701 accgggtgta ttcggcgagt tccgcagggt ccgggtccgc ctcgatcagc gggtgccggc
    11761 gggcgaagta ggtgttgagg ggcttgccct ccaggtgctg catcaccagg aagtggtggt
    11821 cgccgacggt gaaggtgccg tgcaccgagg gcacgcagtc cagcccggcc agttgctcca
    11881 gggccatgcg ttcgcggtgc agccgggtca cggcgtccgc cccgtcggcg gccagccccg
    11941 cgaaggggcg tccctccttg aggacgaccg gttcgccggt gcggacgtcc cggccggcgt
    12001 agaccccgcc gccgttggag aagtgcaggg cacgttcgac cgtgtacgga agacctgcga
    12061 gggtgacggc ggcccgccgg tccagatggg gggccaggaa cgcgggcaag tcgacccact
    12121 ccggcggctg gaacaccgga ccacgggcat ccggaacgag ccggccgtcc ggggcctcga
    12181 tcgccgggac cagctcgccg cggtcgtcgt agcagtgccg cagggtgaaa ctgccgtaac
    12241 gcaggtgcac gggcccgtcg ttccagcgca ggtcgctcag gatgtacggg ccgggctcgc
    12301 cggtgagcag cgcgtcgagc tcctgggcga tcgaccggca ctgcgcctcg tccgccgggt
    12361 acacggtgag gaacttgccg ctcgccgcac ggtcggcgta cttcgcgttg cgcaggtgca
    12421 gcaggtaccg gctcggcacg aacttgaacg cgatccggcg gtccacgcag tagcggtgga
    12481 cccgttcgag gacggactcg gcattgtcca ggcacgccga gacgtggatc ttccagccct
    12541 gggagggcag ccgggcgtcc aggggccgca gcgccagcca gtccccgctg cggtgtgtct
    12601 gccaccccgc cggtacgggg gcgagcgcgg ccggatagct ctcctcggcc cgccggtacg
    12661 gcgcgtcgta gaaccagcgg tcggcgtcgc agaaggcggc gtaccccttg ttcactcctg
    12721 ctccctcggt cggtgacgtc ccaacgctgt cacgcggtgc gagggccgcg acagtcacgg
    12781 ctgtcaccga tggggtgtgc agtacgcacg agtcaacaag ccccgtaccg gggcgggcgg
    12841 gtcagtcctt gctcgccggc tgccagccca taccccaccc gtactcgagg tcggcggcct
    12901 gctgcttgag gatgccgggc gccagcagga ggtacttggc ctcacgccgg acgatcagtt
    12961 ccccccgcac gttctcgatc agggcgatcg cggcgaccgg ggagggaacg gtgcactcgt
    13021 cgaggagcac ctcgatcggc ggaccggcgg gcgggtacaa ggtggcgacg ccgcgcaggc
    13081 ccgcgaagcc ggtggctccg gagtagacga ccacgaacac caggagccgc ttgatctcgg
    13141 ccgcgtgatc gaggttgatc atgaggttct cgccggcctc gctcgcaccg gtccggtcgt
    13201 cgtggtccag ctggacgtag ggcggctggt cgaacgagcc gaactggttg ttgatggggt
    13261 ggacgatccc cttcgttccg ttctggagct cccagaggca ggagaggtcg aggtcgacgt
    13321 cctccagccg gacggcgtcc cttcccttcc tcatccagcc gcgtggtggc tgggcggtgc
    13381 tccatgtgag attgacccgc atgcgcccgg tggtggcccc ctgcttggtc aaggagaccg
    13441 cgggcgccgc cttcgtcaaa gtgatcttcg acagctgcac cggccgggcc ggcgcgggca
    13501 ccacgggtgc aggtgcaggt gcaggtgcag gtgcaggtgc gggtgcgggc ggcagggcta
    13561 cgggcaccac aggcgcgggc gcaggcgggg cgggatcgtc gaccgtgatc ccgaaatcgg
    13621 tggcgagccc cgcgaggccc gaggcgtaac cctgccccac cgcacggaac ttccatgcac
    13681 cgccccgccg gtacagctcc ccgagcacca gcgcggtctc cgtcgtggcg cccgtggcgt
    13741 cgaaccgcgc cgtctcggcg ccgctctgcg cgtccagcac gcgtacgaag aggccggaca
    13801 cctgggcgaa cgtgccgtcg gtggaagccg cgagcacgac ggtcccgatc tcctgctcca
    13861 ccgcggtcag tgcgaccccg atcgtctcga tcgctccggt gccgtcctgg cgcctcccct
    13921 cgtggcgcac ggctccactg cggtggacgg gctggttgta gaagacgaag tcgtcgtccg
    13981 accgcacctt gccggccgcc gtcagcagca gggccgacac atccacatcg ggcgctccgg
    14041 gaccgccccg ccaacccagt tccacccgga ccgtgtcact cggcaccggt acgttggcac
    14101 ccttcagcaa ggacatgtgg gtcccccttc cgagacgtct cccacccccg cagcgtacga
    14161 ggatcggacg cgcctgccgc cccgaagacg gcgattgcct ctgctccggg ggaagttgcg
    14221 ggggcagctc ggtgtacccg gcgcctcagg cctcgcggtc catgacgcgg cgggcggcct
    14281 cggcctccgc agccggcgga gacagttcat cgagggtgtc gagctcgtcg tccgaggcca
    14341 gctcccgctc ccaggccgcc gcgagtcgct cctgctcctc gcgcgaccgg ctcgtcacgg
    14401 cttcccgtcg gtgcggttcc agcaccgcga ggaaacgccc gaccgcatcc gtcggcatgc
    14461 cgtactcctt cttgctgtgg gggaggggca gcggcggtcg cgatgccgtg cccggcccag
    14521 aatggcgaac cggcccgtcg ccggcggccc gacacggcgg gccgccgtcc tgaacttcaa
    14581 cttcactcac ccgaacccgg tgccgccgcg cggccggccg gacggcgtcg ggcagcggtc
    14641 gtccggatca gccccggccg atgaaggcga ggccggccgc cccggggcgc aggtccggcg
    14701 ggagcgccag gtgggcctgg cgcagggcct gcggcagggg cacgccgcgg cgcaggtgcc
    14761 ggtcgtaggt gtcggccagc aggcgtccgg ccagttcgtc gtcgatggcc cagagaccgc
    14821 cgacgacctg cgaggcaccg gccaccaggc aggacagcgc ggcggccgtg gtatcggcgc
    14881 gctcggtgga cttggcagac cagcagcagc cgaggacgac cacccggggc agtccgagcc
    14941 gcagcagagc ggccggcgag gaggggccgt cgggcagcag catgcggtac tcgaagccgt
    15001 cgttctgcgt gccgtgcacg ctgacggtga gaatgtcgta cggggccgcc tccagcgcgt
    15061 cgtggagctc ggccagcgag tgcacccggg tgaagcggat gtgcccctgg gcggccagct
    15121 gctccagggc ccgggcttcg aggcgggagc ctttgagctc ggtctcatcg aagatcccga
    15181 tcacccgggg cacgacgacc gccggggcgg gccgggtgcg cagcgccgcg cccgcggaca
    15241 tgctgatcgt caggtccgcg gcgccgtccg gcgccagctc gttccagggc atcgcccacg
    15301 tgaccgagtc gggcaccacg aggatgcggg cgcccgcggc atcgggatcg acgtcggcga
    15361 agaacaggcg ggagatccgc cggacggcct cggcgggggc gtcctcggag tcctcgccca
    15421 ggcactgggc cagcgccttg ccgtcggccg ccgatacgtg ggtgcgccgc acgagcggta
    15481 ccgggtgcga gggacggagc gtcacgaccg tcaggcagtg ctcaccgact tccgcaccgg
    15541 tgacgttcac ccagagcacg tgatgcccgg ggagggcgtg cgtgatctcg gccggcgtca
    15601 ccggtgccgt ggtccgcgcc aggaagtcca cgagggtcat gtccgcgcgg gcgtcggtgt
    15661 cgtaggcgcc gctgtcctgg gggcggccga cggcggtgcc gccccggaac tcgcccagga
    15721 agtcggcgag ttcggcgacg atctccgcgt cgtggcccgc ctcgtggaga tcgacggccc
    15781 tcatcagcag gcccgtgagg agcagctcga cgtcggtgac ggtgcgggcg gcgaagagat
    15841 cgtcggcgca gagccgggac aggcactccc ggagggcgtt cgccgagggc agcagaccgc
    15901 cctgcacccg cgccgcctcg gcgaacaggc gcatcgccga cctgaagggg ccggcgggca
    15961 gctcctcggc gctctgcccg taccatcccg acgcccccac gtggtcgccc cgcagggcgg
    16021 cctcggaggc gcgggccatg gcgctgtcat gcggcgtggt gctcgccagg gcggaggcca
    16081 ccagctgatg ggcacggtcc ttcgggccga tcgcggcagc cgcccgcgag aactcccgct
    16141 ccgccgccag cccctcgtcg acccggccgc cggcgatcag cacgcgggag cggtagtagg
    16201 tgacgagggc ccggtagccg ggtgtgtcgg cggccgcagc cagcgcctcc accgcgaccc
    16261 ggaggcgttc ggcgttgccc gtcgtgtgcg cggcgtaggc gacggcgccc aggatcttcg
    16321 cgcggcggat ccgccggccg ctgcggccca cctcgtggag cagcgcgcgc aggacggcgt
    16381 cgaccgtgag ggatccgagg acgtacagct gctgccggct ggagatcgcg gacaccaggt
    16441 acaggatcgt ccggtccggc cctcccggcg ccagctcggc ggcgatccgg cggcattgct
    16501 cggcttcctg cgcacggccc agttcctcga agtgcccgcc ggtctcgtcc aggagcgacg
    16561 ccaggaggcg ccgggtgagc ggcttgggcg aggcgcgggc gtagtgctga tcgacggtct
    16621 cgacgatgtg gtcgagtccg accgagtaca ccggacgccg gtccagcacc tggtagagcc
    16681 tggtgatggc ccggacgtcg gtggcgtcga cgtcctccag gtcggtcacc aggtccactt
    16741 ccaggtggcg gcggaccgcg gtgacgacca gcgactcgaa acggctgcgc caggtgccca
    16801 tggcgtggcg gtcagacggc gtcggtgtcg gtgtcgcgga gggcggcccg gtcgacgttc
    16861 tgcgcgggaa ggatcgtccg ctggagcagt cgctcgatct cctccacggt agcctccccg
    16921 tcgaagcgga tctggccgtg cgggccgatg gcctcgacgt acatcctggc gcggtcgtcc
    16981 gggcggccgg cccgccgccg ggacgcgagc gagcggatgg ctccggccag gtaggcgatg
    17041 gtctgcgggg cctgcagcag ggcgatgacc gtcgcggtcc ccgtgatgaa gtccccgtcg
    17101 agcccccact gggagctgcg ccggccgcgg gtcggcgtgg cgtgcccctc ggcgaccagg
    17161 agctccgcga gctcaccggg aacgctcatc ttgatggtgt cgctcatgta cgccctttca
    17221 ccgagcgggc ccgtccgcac cgctcaaggt ccggggtcga tccctcaact cgcctgtccc
    17281 cgtgcagtat ggcccggcgg ccgtcctgcc atccggcatt ccgggattcc cgttccgctt
    17341 ccccggccgg ccggggagcc gtcgcccgca ccgcccgcac cgcccgcacc gcccgcaccg
    17401 ggagagacgc ctgggccttc acttccggat cctgtcggcc gagcccgggg cgatccccgg
    17461 gccgccctgc gggccgtaca ctcggcccat gggtcgcaca cgttcctcga ggcagtgcct
    17521 gcagcaggcc gccttcggga tgcgcccgac cgccggggtc gcgaccctcg tcgacccggc
    17581 cggcacggcc ctcgccgtag cgcccaagac gcgccgtacg gctctgcacg gccacggcta
    17641 gcgcttcgcg cctccgtctc ctccgctcca catcaccaca gcagcttccc ggcatgccgc
    17701 cggcgctgcc gcctggctac ggccgcacgc ccgggcccga gccccctcga agggatcatt
    17761 gtgaagctga gcgcattgct ggccgggcag gagcaccacg ttctccaggg tgatccggac
    17821 acgacgctga tcaccgcggg aaccaccttc gacgccgacc gggtgacgcc gggctcgctc
    17881 ttcatcgccg tacccgggca ccgggaaggc ggccccggcg ccgtctcgcc cgcgctggcc
    17941 cggggcgccg ccgccgtact cgtcgacggc cgtgaacccg acctgccggc cgcggcatgg
    18001 cccccgggca cctgcaccgt gcgggtcccc gacacgcgga cggccgccgc ggtggtgagc
    18061 tcccgctact tcggcgagcc cgggcggcac atggacatgg tggcgatcac cggtaccaac
    18121 gggaagacct ccgtctcgta catggtcgag tccgtcctgc ggatcgccga gggctccagc
    18181 gtgggggtga tcggaaccgc cgggagccgg atcggcgacg agccgatccc catgccgcca
    18241 tcggtgctga ccacaccgga atctcccgac ctgcagtacc tgctggggtg catgcgcgac
    18301 cgcggagccg ccggcgtggt gctggaggcc acctcgatgg cactgctgac gcaccggatc
    18361 gaccggacgt tcatcgacgt cggggtcttc accaacctca cgcaggacca tctggacgac
    18421 cacgggacga tggcggacta ccgggacgcc aagctgcggc tcttccaggg cctgtgccgg
    18481 cgtgcggtgg tcaacgtcga cgacccggtg ggcgcgggca tcgtgtcgat gatgccgggg
    18541 gcggtgacca cgtacgccct ggaccgtccg gccgactacc gggccaccga cctcgtggtg
    18601 acggcctcgg gcacgcggtt caccctccat cacgacggac gcgcctaccc ggcctcgatt
    18661 cccgtccccg gccgcttctc ggtggccaac gcgctggcta ccgtggcggc ctgccacgtg
    18721 ctggggcacg agctgggcgc cctggtcgac gcgctcgacc ggatgccgcc ggtcccgggc
    18781 cggctggaac gcttccggac cccgctgggc acgtcggtga tcgtggacta cgcccactcg
    18841 ccggactccc tggacaaggt cctgaccacc atccggggct tcgcccgcgg ccgggtgatc
    18901 acggtcttcg gctgcggcgg ggaccgcgac acctccaagc gggtcgagat gggccggatc
    18961 gccgggaccc attccgacct ctgcgtcctg acctcggaca acccccgcaa cgaggatccc
    19021 gaggccattc tggaccaggt ggcccccggc ctcacggcga ccggcacccc cttccggcgc
    19081 tacgccgacc gccgccgggc gatcgccttc gccctgtccg cggcgggccc cgacgacacg
    19141 gtcctgatcg ccggcaaggg cagcgaaccg caccagatcg tcggcgaaaa gctgctcccc
    19201 ttcagcgata tggccacggt gcgcgagctg gcccagatct agggggtgga gttccagccc
    19261 tgcgcgtgga gacgctcgaa tccgtcgagg aggaggtcca gcgcgaatgc gaactcgaac
    19321 gcgtcgtcgc agcccgggcc gatgacggaa ccccggtcgt gggccaccga tcgggccagt
    19381 tcggtgacgt gggggtagcg ccgggccatc tcctcgtacg cggccgcctg cgcccgctcg
    19441 tcctgcggtg cggtgctcgc cgggtcgtcg aacagctcct cggtgaagcc cagcacccgg
    19501 ctgccgaggg cgtgcatcac gtggtgggtg aggtcgaggg agaagccgcc ggcccggaac
    19561 atcgcgatca cggagtccag gtaggcgagt acggccgggg tcgggccgct gcgtgaacgg
    19621 atcacctggg ccgcccaggt gtgtgcgagg agggcgccgc gcgcgccgag gatccgcccg
    19681 cggaccgcgc tcttccagtc ggatccgggg gcccggcccc cgatcccggc gacgacgacc
    19741 tccaccatgc cgtccagcaa ctcctccttg ctggccacgt gcttgtagag cgccatcggt
    19801 acgacgccca gctcctgggc gagtcggcgc atgctcagcg cctcgatgcc ggagccgtcg
    19861 gcgaaggcga cggcggcgcg cagcacccgg tcccggctca ggggggtccg gcgtggttcc
    19921 tgcggctgct cgggcatgtg ggcttctccc tcgatccgtt cccgggacgg cggcgcgggt
    19981 gcatcccgcc ttgacgagtg tacggcgtac acctagggtg agcggcagct gccaggtgta
    20041 cgccgtacac cttttgaggg gggtccgttc cgcatgagct caaccaggag aaccgcggtc
    20101 gtcgcgggag tgctgttcct cgtcaccgag gtcgccgcga tcggcggcct cgcgctctac
    20161 cgtcccgtcc tgcacgacgc cgcgtacgtc atcggtcccg gcgccgacac acgggtgttc
    20221 ctgggggcgt tgtgcgaatt cgtactcgcc ctggcggtca cgggcaccgg ggccgtgctg
    20281 tacccggtcc tgcggaagcg gaacgaaggg gccgccgtcg gctacgtctg cggccgcctg
    20341 ctggaggccg ccgtcatcgt catgggcatc atcggcgtgc tgtcggtcgt gaccctcagg
    20401 aggcaggccg agggcgcggc gggcgccgac ggcgcctccc tggtcacggc cggccgtgcg
    20461 ctggtggcct tccacgactg gacgttcctg ttcgggccga acttcgtgct gggcgccaac
    20521 accctggtgc tggccgccct gatgtacacc gcgcggctcg tgccgcggta catcgcggtc
    20581 ctcggactgg tcggcggggc gatgatctgc gcctcggcga cggccgtgct gttcgggatc
    20641 tacgagcagg tctcggtggc ggggtcgctg gccgccctgc ccgtgttcgc ctgggaggtg
    20701 accctggccg tccggctgct ccgcaagggc ttcgacgagg gcgccgacga aggcgcgggc
    20761 accttcgccg acgaacgcgt cggcgaaggt gcccgcgtcg ggtgaccgtt ctcaggacat
    20821 tcgggccacg tgccacagcg gcaggctccg gaagaactcc accgcctcct cccgccagta
    20881 cggcccccag gacgcggcct cggcggaggc ttcctccgcg taccgccgga tctccgcctt
    20941 gagccgccgg tccacgccgg cgccgcgggc gatctccctg atccggccga gagtggcctg
    21001 cgggcagtcg ggatcgccga gcgcggcctc gacgagggcc gcctcggccc cggtcgcggc
    21061 ggccaggagc gcgcggaccg cgtaggtgcg gcggcccgag cggatgtcgg ccccggtgga
    21121 cttcgcctcg tccgccgggt cgtcgccgaa cgggccgaag aggtcgagga agtcgtcgcg
    21181 catctgctcg ccgatgccca ccagcctggc gtaccggtgc agtcgggcac ggtgcggcgc
    21241 cgggtccccg cccgcggcca gcagacccat cgtgagtggc gcgaggatcg agtagcgcgc
    21301 gctcttgaag tccgtgacgg tgtgcaggaa ctcctcgtcg ggcagcgcgt gcgagtcccg
    21361 ctccaggtcg gcgagctgcc cggcgaccgt ctccgccgcg gtccgggtgt gcacggcgag
    21421 cagcgcctgg cgcagctcgg cgggagcctc ggcctccagc aggacctggg tggacaggaa
    21481 cgcggcgagg tccccggcga gtatcgcgag cccgagggcc gtggcaccgt ggtcggggaa
    21541 ctcccggcgg taggcgtagt acgtcgaggg cccgccgcgg cgcagcggcg cgtcgtcgat
    21601 gatgtcgtcg tggacgagcc cgtgcgtctg gagcagttcg atgctcagtg ccgcctccgc
    21661 gagccccggc acctcgtcgg tggtgaccag ccgggccgcc tcgtacagca ggacgacccg
    21721 cagccgcttg ccgccgcgca tggagaactc ccgcaggagc tccaggcacc ggggaacgta
    21781 ccggctcggc accggcacgt cgaagcgctc gccgaggccg tcgaagtact gctcgaagcg
    21841 ggagtcgaag cgcgtccggt gcagggcggc gcgttcgagg gcggcggtga cgttggcatg
    21901 catgaagatc agtatcccta cgactgcggg cggcggagca tggagaggtg acgggccggg
    21961 tcccacaatg gaggccggcg agcgggaggg gtgcggtatg gcggacgaac aggcctcggt
    22021 gcgggtggag cgggacggcc ccgtgtacac ggtgatcctg agcaggtcgg gggtgcgcaa
    22081 tgccgtggac ggcccgacgg ccgagcgact ggccgacgcg ttccgggcgt tcgtccggtc
    22141 ggcgcgaccg aggcgcacgg gatcggactg gccaaccggc tggtccccac gggccggtcg
    22201 cggacggcgg cggaggaact ggcccgcgag atcgccgggt tcccgcagat ctgcctgcgc
    22261 cacgaccggt tgtccgtcct ggagcagcac ggactgcccg aggccgaggc cctggcgggg
    22321 gagcaccggc acggcctggt gccactggaa gcgggcgaaa cgcaggcggg cgcgggccgg
    22381 ttcgcctcgg gtgccggtcg gcacggctcg ttcgggcagt gaccggcgag ccgcggcgcc
    22441 acccgtagcc gcccaggggc tgtaccacgg cccacccgtg gtgtgacccg gatcacctcc
    22501 tggggaaaac ctgctgcccc ggccgcacgt ctagcaggtg tgaaacgggt tggggcggca
    22561 gcgccgcagg aactggacga ggaacgtctc ctacgacggg tggcccgggg agaccgggcc
    22621 gccttcgagg agctgtaccg gcgcacgtcg ccgtggctgg cggtgcggct gcgccgccgc
    22681 tgcgccgacc agcagatcgt cgccgaggtc atgcaggaga cttacctcgc ggtgtggcgg
    22741 gccgccggct ccttcgccgg gaccgggagc gggagtggga ccggcggaac ggccgtcggc
    22801 tggctctgga ccatcgccgc ccgccgcctc gtcgacgcgt tccggcgcag ggcccaccac
    22861 gcgcagccgc cgcccgccgc cgccccgtac cccgtcgcgc ccgcagccga ggaggaggcg
    22921 ctggtcgcca ccgtcggcgg tgacgtcggg gacgcgctgc ggcgcctcgc gccggagctc
    22981 agggacgtac tgcaggccat ggtgctcgac ggactctccg tccgtgagac cgcggtcctc
    23041 ctcggactgc ccgaaggaac ggtcaagacc cgcgcccgcc gggcccggac ggctatgcgg
    23101 gaggcgctgg catgaacgtg gaacacgcgt cggcacggct gatcgacggt tacgcgcgcg
    23161 gcgggacgga tctcgccgcc gacgagctct gggccctgga ggcccacctg gaggggtgcc
    23221 gggtctgccg tgaccggctc tcggacgccg tcacggccgg ggcgcccgcc gtggccgccc
    23281 tgaccgaggc cgtctggtcc gacctcgaac accacatcgc caccgccccc caggcgccgc
    23341 cgcgccggct gctggcacgg ctgtcggcct ggaccacacc cgccatgacg ccgtggctcg
    23401 ccatggtcct ggccgtcacc ctgctcgccc tgctgctcga cctgacgggg cccggctccg
    23461 gagtcggttc cggctccggc cgggtgtccc tgatgctgct gctcgccccg gtcctgcccg
    23521 tgtgcggagt ggcggcctcg tggtcgcgcg ccctggaccc ggcgtacgag ctgacgtcct
    23581 ccaccccgag ggccgggctg caactcgtgc tgcggcgcac cgcctccgta ctcgccgtgg
    23641 tgatccccgc actgctggcg gggggatggg cgacgggggt gacggccgct caatggctgc
    23701 tcccctgcct ggccttcacc tcggcgaccc tggcgctcgg cggggtcatc ggcgtgtccc
    23761 gcgccgccgc cgtactggtg gccgcgtggg cggcggtggt ggtggcgccg accctggcca
    23821 ccagccggac ggccgtcgcc ctcgggacgg acggcatgcc ggtgtggggg gcggtcctcg
    23881 cgctcggcgt cgccgtcgtg atcgtccgca ggggcgccta caccacgccg ggagcccacc
    23941 gttgaacccg tcgaagacaa ggaaccgcat gaagccgaca gtcagcaggg ccgacctcgc
    24001 acccacggcc tacgcctggc agatccgggc gaccggactg aaggtcaggg ccggcaggaa
    24061 gcggatggcc gtcgacgggc tcgacctgtc gctgggcacc ggagtacacg gtctgctcgg
    24121 tcccaacggc gcgggcaaga ccaccctgat tcgcgccctg gccaccgtgc tgcgtcccgc
    24181 cgggggcgag ctggaactgc tcggccaagc tgtgggcgca ctgggcgagc accgtgcgct
    24241 gcgccgccgg atcggctacc tgccgcagga gttcggctac tacaagcgct tcacggtacg
    24301 ggagttcgtc gagtacatgg catggctgaa ggaggtcccc acggccgaca tccccggtgc
    24361 ggtgcagcgc gccgtggagc gggtcggcct ggccgaccgg gccgacgagc ggatgaaggc
    24421 cctctcggga gggatggtgc ggcgggccgg catcgcccag gccatcgtca acgacccggc
    24481 ggtcctgctc ctggacgaac cgacggtcgg cctggacccg gcacaacgcc tgcgcctgcg
    24541 cgaactgctc caggaactcg ggacggacac ctgtgtggtg gtctccaccc acctggtgga
    24601 ggacgtcgcc gcggcctgca ccgatgtcgt gctcttcgcc gagggaaggc tggtcttcca
    24661 gggcaccccg ggcgagctgg ccgcggcggg cggcccggaa cacgacggcg acagcccgct
    24721 ggaacgcggc tactcggcgc tgctggtcga ccccgcgcgg acgaggggcg cctggtgaac
    24781 ctccgtatcc tgggcatcga gctgaggcgg tccgtcgccc cctgggccgg catcgtcgtt
    24841 ctggcgaccg cgctcgcgtt cctgtacctc gttcccggac cgtggtggag gggcaccgcg
    24901 ctgtggacgg cccagtggac ctccatggcc ctctggaccc ggtacccgct ggtcttcctg
    24961 tggccgctcg ccgtgggact cggggcgctc cagggcctgc gcgaccaccg ctcgaagatg
    25021 tccgaactgc tgatcagcac cccgcggccg gcccggcacc gcgccgccgc cctcgcgggc
    25081 acgacggcct tcgccctggt gtcgtccttc gcactcctgg tcgtgctggg cgcggtgcgg
    25141 gtgctcgccg gcgacgccac gtacacccac ctcggctggc tgcccatctc cctggtgggg
    25201 gcgctcgcac tgacggcggg ggccgtcctc ggcatgggga tcgcgcgaac ggtgccctcc
    25261 gccctcaccc cgccggccct ggccgtgggc gccttcctgc tcaccagcct cctgcggcag
    25321 acctcggacg ccgcgacgcc gacctccgcc gtaccgaacc gcctctcgct gctgtcaccg
    25381 gcggtggcgg aggcgcgcga aacgctcctc acgctctccg cccccgtgca cctcggccag
    25441 accatctggc ttctcggcat ggccgtgacg ggcttcgtgc tgctggcggc cgccaccccg
    25501 cgggcccggc tgctcgccct cacccccttg ctggcgggcg cggccgtcgc cctgctccag
    25561 ttcccggccg acccccgcgc cacgtacgtg gtcgaccggg aggcggcaac cctcgtgtgc
    25621 gagggcccgg tgtgcgtgac gacggcccag cgggcgcgga tggaggacct ggaggctccc
    25681 ggcgcggagg cactgcgcct gctgcgcgag acactggggg accgggcgcc ggtcggcctc
    25741 cgcgagacca ccgtcccgcg ggcgctcggc gatacgccgg aacggtcgcg cgcgtacgtg
    25801 ctcgtcgact tcgacgacgc ggcgatcggc gacgccgagg gcgaggaact gacccgggcc
    25861 ctggtcggcc agggcatcgc cccgctgtgc cgcccccgca gcgacaccga gagcggcacg
    25921 ctggaggagg ccgtcgccca gagcatcgcg gccgcctggg tcctcgggga gctccggccg
    25981 ctcgaaggca ccatgcacga cccgagcgag caggccgccg tcgccgaccc cgtgtggaag
    26041 cagttcatgg cgcttcccag ggcggagcag cgacagggga tcaccgccct gcacgccgcc
    26101 gccgtctcct gctcgggcga cccgctcggc gcgctgaccg gcggggcgtc ccggtgagat
    26161 ggctgacgct gtacgcccgc tcgcgacggg cccccgcatc gctcgccgcg gtgctgatca
    26221 gcgcggtggc cgtaggggca ctcgcccgga tcggcggagg cgggcccgtg gatccgcggc
    26281 tgtccacgct cgccctcgcc gcgggcgcga cggcgctcgc ggtcggactc ggcgggcagg
    26341 acctcgcgtt ggaccgcacg gccgcgatcc gctgggtgcc gcgcagggcg gtgcacgtac
    26401 tgctctgcgg gatgctgatc ggcgcggtgc tgctggcggt gcagacgatg gaagggcagc
    26461 cggcctccac cgcgctcgtc gtgcgcaaca gcgcggggct gatggggctg gtcgccctgg
    26521 gagcggcctg gtgcggcggt ccgtacgcgt ggatcccgcc gttcgcgtcg ctgtcgctgt
    26581 ccttcgtcgt cccgcccgcc ccggacccgg cgacgcaggt gctgacctgg atgctgctcc
    26641 cgcccggcac gacggccggc gtctggacgg ccctcgtcct ggccgtcgcg ggcaccacgg
    26701 cctacgccgt cgcgggcccg aggcgctagc gagcaccggc gggcgggtcc gggcggggtg
    26761 tggtgcctgc cacagcccgg cccgggaacc cggccggccg cggccccgac tcctggtgcg
    26821 gagcgcatgc aggcacatgc tcggaaggga ccagcggatg aaccgcagga acgtgctccg
    26881 tgccccggtc gtggtgggcg gggtagcggt accggtagtc gcaggtcagc ggtgcaggcg
    26941 ccgggtccag tcctcgggga cccggtcggc cgggccgggg gtcggctggt ccgccgggcg
    27001 gtcgctgggc ggggtcagcc ggggtccgga gtcgtacagg gcgtcggtgt cgtagttcca
    27061 gaaccactcc tcgcccggct cgaagctctg caccagcggg tggccggtgg acttccagtg
    27121 tgcggtggcg tgctgggcgg gggaggagtc gcagcagccg atgtggccgc actgggcgca
    27181 gcgccgcagg tggaaccacc agccgccgag ctcgtcgcac tcgacgcagc cggttccggt
    27241 gggcggggtg ctcgggtcga taccgttcat gtcggtcatg cgggctcctc ggcggtagcg
    27301 gtcgcggcaa tctcggatgc ggcggtctcg gttgcggcgg tctcgttcgc ggggtccggg
    27361 gcggtcagcg gcagcagcac ctggaagcgg gtgtcgcccg gggcggactc gacctggagg
    27421 ctgccgtggt gcttgttgac gatgatccgc caggagatgt cgaggccgag tccggtgccc
    27481 tcgccgaccg gcttggtggt gaagaagggg tcgaagatgc ggctgcggat gtccgccggg
    27541 atgccgggtc cggtgtcgcg gaactccacc atcagacggt cgccctcgcg cgccgtgcgg
    27601 acggtcagcg tgccctcgcc gcccgtgctc ccgatggcga agaccgcgtt gtcgacgagg
    27661 ttggtccata cctggttgag ctccgcgggg taggcgggca cgtcgggcag ggagcggtcg
    27721 tagtccttga ccacccgcac ccgggagccg atcttgccgg acagcatcag cagagtgctg
    27781 tcgaggagtt cgtggacgtc gacgacccgg tacggggcgc ggtcgagctg cgagtactgc
    27841 ttggccgcgt ccacgaggtg ggagatgcgg gtggtggaat cgtcgatctc atccatcaac
    27901 agctcggtct cgaccgtgta gttgagccag ccgatggccg acggcaggat ctcctccgcc
    27961 acggccgccg cgacctggtc cagccagtcc gtgtccagtc cggcctgcac gaagaccggc
    28021 gcgatccgcc agccctccgc gatgtcgtgg tcgtcgagcc agtcggcgag ctcgtcctcc
    28081 cggtcggagg cctccagggg gctgagcgcc gtcgccttcg cgacgcgttc gacggtgcgc
    28141 tcctgcatct cgatgaggtc ggcgatcacc tcgcgcgagt actggccctg cgagatgtgg
    28201 gccagcttgt gccgcatctt gccgacccgt tcccgcagcg tcgccgtggc ccggacggcc
    28261 gcggccgccg ggttgttgag ctcgtgggtg agaccggcgg acagcgatcc gagcgccagc
    28321 agccgctcac gctgcccgat cgcccgctgg gtgttcttgg agccgaagaa cagcccttcc
    28381 agcaggtgcg ccgccatcgg gaaccactcc tgcatgatgt ccgcgaacga ctgcgcgggc
    28441 agcacgaaga accgcgtcgg ttcggtgacc cgcatcgagt tggtgtacgt ctgcggcacc
    28501 tggtcgccca ggtacgcctg catggccccc gcgtacacac cgcgctgcga ggtgcggctc
    28561 acctcgacgt cgtcgccgcc gacccggcgg aacagcacga cggtgccctc gatcatcacg
    28621 tagaagcagg tggccgggga gccctcggtg tacacggggc cggcttcgaa ccgctccacc
    28681 cgcccctcgg cgcacaaccg tccgagctgc tccggggtga gcttctcgaa caggaacagc
    28741 gagccgatct cctgcgggct gcacggcatg acctgtccgc tcatgactgc tccagatacc
    28801 ggtggacgag catcacggcc atggccccct cgccgacggc ggacgcgacg cgcttcgcgg
    28861 actgggcgcg cgcgtcgccc gccacgaaca cgccgggaat gttggtctcc aggtggtagg
    28921 gcggccggtc cagctcccac tcggccggcg gccgaccgtc cggggtgagg tccggtccgg
    28981 ccaggatgaa cccgtgctgg tcgcgcagca ccgtaccgtc cagccagtcg gtcagcgggg
    29041 cggcgccgat gaacacgaac atccactgcg cgtcgacgag ttcggtggca ccgctgtcca
    29101 cgtcccgcag cgtcagctgc tccaggtggc cgtcgccgtg cgcggcctcg acgaccgtcc
    29161 gggtgcgcac cgtgatgttc ggcatctcct ggatctgctg gatcaggtag tacgacatcg
    29221 acgccgccag ggactccccg cgcaccagca gcgtcaccga cttggcgccc cgcgccaggt
    29281 acatcgccgc ctgcccggcc gagttggcgc cgcccacgat gtacacgtcc tggccctggc
    29341 aggaggtcgc ctcggtgagg gaggagccgt agtacacccc gcagccggtc agctggtcgc
    29401 agcccggcgc gtggagctgc cggtacgaca cgccggtcgc caggatgacg ctgtgggcgg
    29461 cgatggccga gccgtccgag aagtggacga cgcgggccgc tccgttgacc tccagccccg
    29521 tgacctcgcg cgccgtgagg atctcggcgc cgaaccggcc ggcctggcgg cgggcgcggt
    29581 ccgtgagctg ggcgcccgac acgccgtccg ggaagccgag gtagttctcg atgcgggagc
    29641 tctggccggc ctgaccgccg gtcgccgacc gctcgaccag tacggtacgc agcccctccg
    29701 aggccccgta caccgccgag ccgaggccgg ccgggccgcc gccgatgacc acgaggtcgt
    29761 agaactcggc cgtcggcgtc gtcgcgagcc ccacgtgggc tgccagctcg ggcgcctccg
    29821 gctcgatcag cgcggtgccc tccggcgtga tcaccagggg cagccgctgc ccgtccgccc
    29881 cggccgcctc cagcaggcgc tgcccctccg gctcgtcgga ggagtaccag cggtacggca
    29941 cctggttgcg ggccaggaac tcccgtacgt ccgaggagcg cgccgaccag cggtgcccga
    30001 ccaccttggt cgcgggtacc ggccggtagt cgctggtgcg ccaggccgtg agcaggtcgt
    30061 ccaggaccgg gtagagcttc tcctccggcg ggtcccaggg cttgagcagg tagtggtcga
    30121 ggtcgacgac gttgatggcg tcgatggccg cgttggtatc ggcgtaggcg gtcagcagca
    30181 cgcgccgcgc acccgggtac acctggaggg cctgttcgag gaactcgatg ccgttcatct
    30241 gcggcatgcg gtagtcggcc aggatcacgg ccaccaggtc gccccgcagc ttcagctcgc
    30301 gcaacgcctc catcgcggag tcgccggact cggcgcgcac gatccggtac tcggcgccgt
    30361 agcggcgccg caggtcacgg gcgatggccc gggagactcc cggatcgtcg tccacggtca
    30421 ggatgacggt ccgcgctgcg tcggcggcct gtgccatacg tcgtctccac cccgagtgct
    30481 ctgggcaggc ggcacggcga gccgcccgcg ccggttcccg cccatcgtat ggtcgatcct
    30541 gcgggaccgc tccgggacgc cgcggccggt gcgctcccgg tacacacccg gtcgctcctg
    30601 gtcagcagcc tgcggcggcc cgctccgggc tgcgcggacg ccggggcgtg cccggccacc
    30661 ggctcacgcg ccggtgtcga cgatgcggcc gtcgcgcagc tccacgaccc ggtcggcgag
    30721 ttcgatcagg ttcgggtcgt gggtggcgac caggatggtg accgactcgc tgcgcaccac
    30781 ggcgcgcagc agctccatga ccgagcggcc ggtctccgag tccagctggc ccgtgggttc
    30841 gtcggcgatg atcaggtcgg ggtcgttggc cagggcgcgc gccaccgcga cgcgctgctg
    30901 ctggccgccg gagagttcgc cggggcgttg ctcggcgtgg tccgcgagcc cgaccagggc
    30961 gagcagggtc cgggcccgct cctcgcggat cctggcgggg acgcggcgca gccgcatcgg
    31021 cacgcccacg ttctcggcgg cggtgagcac gggtatcagg ccgaaggact ggaagacgaa
    31081 gccgatgcgg tcgcggcgca gggcgagcag gcccggctcg tcgaggtccg ccaggtcggt
    31141 gccgtcgagg gtgatccggc cgccggtcgg ggtgtcgagg ccgccgacga ggttcagcag
    31201 ggtggtcttt ccggagcccg accggcccct gagggcagtg agttcgccgc ggcggacctc
    31261 gaacgagacg ccgcgcaggg cgtgcacggc ctgcggcccg ctgccgaaac tgtggtgcac
    31321 gtcgtccacc accacgatcg gcgagccgtc gccctcccgc accgccgtcg cgaccgtggc
    31381 cggttcctgt tcctggtggt ccctcatcgc gtctgttccc ccgtcgcgtt gtccgtgtgg
    31441 ggcgcccggc ccctcgtccc gcacaccctg ccgttgcagc tttctgatcg catttgcgca
    31501 tctgccgcac caatcacgca agccccttcc ctcgatcgac catttctgaa agcatcgtcc
    31561 gctatccggt accgagggtc cggacggggg aggaattcaa gacgtgctcg gcttcgtcgt
    31621 gcgccgactg cgcgggcgat ggccgctcgc ggtcgccgta ctgctcaccg tactgatcac
    31681 agcgaccacg ctgaccgccc tgacggcgtt cacccgaggg gtgggcgagg aggggctgcg
    31741 cagggccctc accggcgccg aacagccccg gaccaccgtc gtgatcacca gcggccgtcc
    31801 cgcatcctcc cgcgccgagg acgacaggtc cgtacggacc ttcgcggacg aggtgttcgg
    31861 acggttgccg gtggccgccg agagcgtggc ccgcagccgg tcc
//
