LOCUS       NZ_BMVL01000002        21374 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000002
VERSION     NZ_BMVL01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 840996)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 793120
            Orig. end                         :: 814494
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21374
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21374
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21374
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11374](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11374)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            119..1684
                     /locus_tag="IE257_RS07980"
                     /old_locus_tag="GCM10010343_16430"
     CDS             119..1684
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743715.1"
                     /locus_tag="IE257_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16430"
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_189966044.1"
                     /transl_table=11
                     /translation="MHDAPDTWAGPPPRSGAAPLVRMRGLSKRFGGTLALASVDLDIHR
                     GSVLALLGPNGAGKSTLIKVLAGVHHADEGQVTVAGHPLGSHAATRSMSFIHQDLGLVP
                     WMTVAENIALGTGYPRRSGLISWRRTRQRCDEALRIVAGHLDPDARISGLGPAERSLVA
                     IARALATRAGLIVLDEPTATLPAADCARLFDVLHALRDRGHGILYVSHRLDEVYEVADT
                     FAVLRDGRLVDRGPLAGHSPERLVRAIVGHVPAGPAPVGRVPGAPPVAGTPLLRLDGVR
                     TASTGRVGLDLRAGEILGMVGLTGAGHMELGRALAGARPILEGRVLLDGRPYHPRSVHA
                     ALDAGVGFVAANRQEEGCAAELTVRENFLANPRASGTPTAHWINPRRERAEALALIDRF
                     SVHPRRSEVPIATLSGGNQQKVMVGRWLRGHLRLIVLEEPTAGVDVGAKATIHRLLDDA
                     LGSGLGVLLISTDFEEVADVCHRALVFVRGSVSAELSGASLTVAELTRTASAMPAITGT
                     TTDR"
     gene            1681..2703
                     /locus_tag="IE257_RS07985"
                     /old_locus_tag="GCM10010343_16440"
     CDS             1681..2703
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005324.1"
                     /locus_tag="IE257_RS07985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16440"
                     /product="ABC transporter permease"
                     /protein_id="WP_189966047.1"
                     /transl_table=11
                     /translation="MTTSPPPPPSPSSSPRSLLDHLRGHHIGTYGLLILAVLLFLVFSV
                     VLPDTFPTRDNVSSILSNQSIPAILALGATIPIATGKFDLSMGYGLGLAHVMVLQLIVN
                     TGWPWPAACLTVVLGGALVGVLNGVIVEYVRIDSFIATLGTGSMMYAATGWITDGSRIV
                     PGPDGLPASFTGLYDSRFLGLPLPAYYVIALAAGLWVVLERLPLGRYLYVIGSSRRTAD
                     IIGIPSHRYSVYAFAGSGLVTGLAGVLLAAQQQTGNPSVGLDYLLPAFVGALLGSTTIK
                     PGRVNALGTVVAVAVLAIGLAGIGQLGADFWATPLFNGATLLIAVGLAGYSARRRLRTP
                     "
     gene            2737..3885
                     /locus_tag="IE257_RS07990"
                     /old_locus_tag="GCM10010343_16450"
     CDS             2737..3885
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118388.1"
                     /locus_tag="IE257_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16450"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_189966049.1"
                     /transl_table=11
                     /translation="MYPKDPHRRTILRTAALLTAAAALVAGCGGGGPSTGAAPPKAGCP
                     GVLAAAGAAVAQAEKADTSWHGPTTGPAAVPGKSIVYVAQTMTNPGVAGVAKGIQEAAK
                     AIGWRVRVIDGDGTPAGIQAALSQAITLAPSGIVIGGFDPQLTSQQMARAEAARIPVIG
                     WHAVGSPGPSEHPRLFTNVTTKVEDVARISADWIIARSKGGAGVVLFTDDSIPFARNKS
                     ELIRKELATCPGVRLLSYENIPIPDAASRTPQAVSSLLSRFQDEWTYSVAINDLYFADA
                     APALRAAGEPGAGPPFNIGAGDGDPSAFQRINSKQFQAATVPEPLNQQGWQIIDEFNRA
                     FAGQPASGYVAPVHIATSENSDGATSWDPSGYREAYRRIWAG"
     gene            complement(3949..4716)
                     /locus_tag="IE257_RS07995"
                     /old_locus_tag="GCM10010343_16460"
     CDS             complement(3949..4716)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742178.1"
                     /locus_tag="IE257_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16460"
                     /product="NPP1 family protein"
                     /protein_id="WP_229920187.1"
                     /transl_table=11
                     /translation="MRTNRHIRRSLVVLGAALTVVVAVPQVAFAAPPPALPGKAEAIEL
                     TYQPAYDYDTDGCYPTPAIGPTGVLNGGLKPTGALNGNCRDASDLANTNGYSRWTCNNG
                     WCAVVYALYFEKDQALPGIELGGHRHDWEHVVVWIQGNEAKYVATSAHGDFNIHSRDQI
                     RWDGNHPKIVYHKDGIGTHCFRAANTNDEPPENHRGTWQFPTLVGWSGYPATLRDKLTQ
                     ADFGSAHFGLKDGSFASHLAEAKPAGIPFDPYL"
     misc_feature    complement(4684..4686)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4887..4901)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.89"
                     /tool="antismash"
     misc_feature    4889..4905
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            complement(5230..6096)
                     /locus_tag="IE257_RS08000"
                     /old_locus_tag="GCM10010343_16470"
     CDS             complement(5230..6096)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (13-175). E-value: 1.7e-15.
                     Score: 49.3. Matches aSDomain:
                     nrpspksdomains_IE257_RS08000_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268084.1"
                     /locus_tag="IE257_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16470"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189966051.1"
                     /sec_met_domain="adh_short (E-value: 3.3e-32, bitscore:
                     107.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLPATPGTSTRTVLITGTSSGIGLAAAIAAARAGWRTVATLRD
                     TGRADALRKAAVDAGVALDIRQLDVVDEASVAAAVEGVIADYGRLDAVVNNAGAGHVGT
                     LELETVADVREVMEVNFFGVLNVSKAALPHLRATGGRLITVTSVGGVVGQPFNEAYCAA
                     KFAVEGYMESLAPVAGAVGVGVTVIEPGAVATEFVNNIDLDLEARIAAAGPYSDALRHY
                     VERTVGQFLNGAQTPAGAAESVMEALTAERPAFRIQTSEWARDFTGNKLVDQDGSAVVG
                     MTATWVA"
     aSDomain        complement(5572..6057)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS08000_PKS_KR.1"
                     /evalue="1.70E-15"
                     /label="IE257_RS08000_PKS_KR.1"
                     /locus_tag="IE257_RS08000"
                     /protein_end="175"
                     /protein_start="13"
                     /score="49.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLITGTSSGIGLAAAIAAARAGWRTVATLRDTGRADALRKAAVD
                     AGVALDIRQLDVVDEASVAAAVEGVIADYGRLDAVVNNAGAGHVGTLELETVADVREVM
                     EVNFFGVLNVSKAALPHLRATGGRLITVTSVGGVVGQPFNEAYCAAKFAVEGYMESLA"
     gene            6185..6667
                     /locus_tag="IE257_RS08005"
                     /old_locus_tag="GCM10010343_16480"
     CDS             6185..6667
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601811.1"
                     /locus_tag="IE257_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16480"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_189966053.1"
                     /transl_table=11
                     /translation="MPKKLTEAEMPTADYAFYGLVWAGTVMTDRVDRALVKAHDLPVSW
                     FEVMLWLASSPEPVPASVLGNSTLLSRSQVSRVVDALQTRGLVTRTPSARDARSVEVSL
                     TEAGRTVFAEADTTRREALAPVFTELLDEQDLEALGTVWRKLKAAKAAQAEQERTR"
     gene            complement(6695..7327)
                     /locus_tag="IE257_RS08010"
                     /old_locus_tag="GCM10010343_16490"
     CDS             complement(6695..7327)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268184.1"
                     /locus_tag="IE257_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16490"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189966055.1"
                     /transl_table=11
                     /translation="MATPSSKAGTKGVPRERRRRQMLEAATEEFGRHGYAAASLPAIAA
                     RVGVTKTLLHQYLGSKEDLYVACLVPVGDRLLGAVREAMGEGGTAPHTPLRVLHGIFTA
                     LEGRREAWFVLYDTTLPPGGEAARRASEYWAAIDRLAAGGTAELLSAAGSTDPLDADAL
                     KYVWRDLVATLVRWWVKHPEQTPEAMTQRCARLFAAAATLTPEGRSA"
     misc_feature    complement(7341..7357)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.36"
                     /tool="antismash"
     misc_feature    complement(7356..7372)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            7392..9008
                     /locus_tag="IE257_RS08015"
                     /old_locus_tag="GCM10010343_16500"
     CDS             7392..9008
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238005.1"
                     /locus_tag="IE257_RS08015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16500"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_189966057.1"
                     /transl_table=11
                     /translation="MAGTTSQPTSRTRSWWGWGWTDAHPDDAECTAMGALLPGTLGRPL
                     PVPRVSDLEIAGPAVEPPPSLAHLVSTDREDRAAHSMGKAYRDVARALRGRPGRVPDLV
                     ARPTDDRDVADLLDWAGERQVAVVPYGGGSSVTGGVEYRGDAHRAVMSLDLTAMGRVLE
                     VDTEGRAARIQAGTLGPSLEDQLRPHGLTLRHFPQSFEFSTLGGWLATRAGGHYATGRT
                     HIDDFVQSLRVVTPAGTSSSWRLPASGAGPSPDRLFLGSEGALGVITEAWVRLQERPRH
                     KASAAVAFADFQGALRAVRALAQSDLSPANCRLLDSGEAALSGAAHDGSSVLVLGFESA
                     DEPVAARLERAVALARSHGGRYGGADGAVGDRDGAPDGEGAVSAWRSAFLRMPYLRDGL
                     ARMGAVVETFETAATWDRIPGLIDEVRREVGAAAVKATGHPATVNCRLTHVYPDGAAPY
                     FTVLAAGRAGDEVAVWDELKAVASEVLHRHRATITHHHAVGRDHRPGYDRQRPEPFALA
                     LRAAKGALDPRGILNPGVLVD"
     gene            complement(9098..9985)
                     /locus_tag="IE257_RS08020"
                     /old_locus_tag="GCM10010343_16510"
     CDS             complement(9098..9985)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576151.1"
                     /locus_tag="IE257_RS08020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16510"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_189966059.1"
                     /transl_table=11
                     /translation="MTSTDLTTAAGTSSVFIPGPATPYQGDIARYWDHEARPVNLRLGD
                     VDGLYHHHYGIGDIDHAALGDTADSAYEKKLIAELHRLESAQAELLLQHLGHIERDDTL
                     VDAGCGRGGSMVMAHQRFGCKVEGVTLSAKQADFANRRAEELGIGDHVRARVCNMLSTP
                     FETGQAAGSWNNESSMYVDLQDLFAEHSRVLAVGGRYVTITGCWNPRYGQPSKWVSQIN
                     AHFECNIHSRREYLRAMADNRLVPQAVIDLTPETLPYWELRATSSLVTGIEEAFIESYK
                     DGSFQYVLIAADRV"
     misc_feature    9997..10010
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.68"
                     /tool="antismash"
     gene            complement(10001..11374)
                     /locus_tag="IE257_RS08025"
                     /old_locus_tag="GCM10010343_16520"
     CDS             complement(10001..11374)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378420.1"
                     /locus_tag="IE257_RS08025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16520"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_189966061.1"
                     /sec_met_domain="T1TS (E-value: 2.1e-69, bitscore: 230.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDPGPSPLQSSLPAAAASFGAHILANALAAGVEPAAGAGPVEPS
                     PPSPPALPTGPPVLTPAIAHAPVPVPVPVPDGSAAAVDAPQPSAAALERILRGPSGLGT
                     ESLHWARSEAAAAAGSAPAGPDASGPAAGRPIPGLYHHPVPDPDPVRVEELSRRIKAWA
                     LDEVSLYPEDWEDQFDGFSVGRYMVACHPDAPSIDHLMLATRLMVAENAVDDCYCEDHG
                     GSPIGLGGRLLLAHTALDPLHTTKEYAPQWEASLLSDAPRRAYRSAMEYFVQASTPSQA
                     DRYRHDMARLHMGYLAEGAWAQTEYVPEVWEYLAMRQFNNFRPCPTITDTVGGYELPAD
                     LHAQPAMQRVIALAGNATTIVNDLYSYTKELAGPGRHLNLPVVIAEREKCSDQDAYLKA
                     VEVHNDLMRDFEAAAAELALACPVPSVQRFLRGVAVWVDGNHYWHQTNTYRYSLPDFW"
     misc_feature    complement(11377..11392)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            complement(11479..12891)
                     /locus_tag="IE257_RS08030"
                     /old_locus_tag="GCM10010343_16530"
     CDS             complement(11479..12891)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267883.1"
                     /locus_tag="IE257_RS08030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16530"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_189966063.1"
                     /transl_table=11
                     /translation="MTVDTSPEAQLEPPRQSSLSTAAARNLASTTKSAPQMQEITSRWL
                     VRMLPWVETKGGTYRVNRRLTYTVGDGTIEFVQDGANVRVIPRELGELALLRGFEDDEV
                     LTALAGRCVQRDFRAGEVIVERGTPADQIHLIAHGRISQTSVGKYGDDVAVAVLADGDR
                     FGENALLDADATWDYTATAETPGILLTLSRGDFASVLAAAPQLQAHIDRFSMLPQQRQN
                     RHGEAEIAMSAGHTGEADLPGAFVDYELKPREYELSIAQTVLRIHTRVADLYNGPHNQT
                     EEQLRLTIEALRERQEHELINNRDFGLLHNAAFKQRIQTHSGPPTPDDLDELLCRRRGS
                     KFFLAHPRTIAAIGREFNARGLYPDHVDVGGQQVPAWRGVPILPCNKIPISKENTSSVL
                     VMRTGEDNQGVIGLRQTGIPEEYEPGLSVRFMGISEQAIISYLVTTYFSAAILVPDALG
                     VLENVQIARRRD"
     gene            13286..14203
                     /gene="bla"
                     /locus_tag="IE257_RS08035"
                     /old_locus_tag="GCM10010343_16540"
     CDS             13286..14203
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) Exo"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601733.1"
                     /locus_tag="IE257_RS08035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16540"
                     /product="class A beta-lactamase"
                     /protein_id="WP_229920188.1"
                     /transl_table=11
                     /translation="MKTQGASPSRRALLTVGAGAALAAALPVGAARAASRHGEGEVVAR
                     LRELEREYGARLGVYARDTATGRTVVHRADELFPMCSLFKTVAAAAVLRDLDHDGAHLA
                     KRIHYTLQDVTDAGGGSITERPENIAGGLTVAELCSAAIAQSDNAAGNLLLRELGGPTA
                     VTRFCRSLGDRTTRLDRWEPELNSAEPSRVTDTSSPRAIGRTYARLALGDALDSGDREQ
                     LNRWLLSNTTSGDRLRAGLPKDWAVADKTGAGSYGTNNNVGIAWPPERPPVVLAIMSTR
                     PEPTAPRDNTLIARTAKLLADTLV"
     gene            14331..15368
                     /locus_tag="IE257_RS08040"
                     /old_locus_tag="GCM10010343_16550"
     CDS             14331..15368
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_16550"
                     /product="hypothetical protein"
                     /protein_id="WP_189966067.1"
                     /transl_table=11
                     /translation="MAVLFYRRTTVDEPGGTSSRAARRSGLLPQSRQHTGRAAPDPELE
                     RAAAAAARGSWEPAARLMAGTRERADWARRSSYAATLGSHRAARPDSWLHAWEAAAGPD
                     DADLALVRAKAMVNLAWHRRGGGWAKNTSAEQFAGFHATLARVPQENARAAELNPEDPT
                     PYVNEIWAGLGLGYDEEGMQRIWKEITTRDPHHYDAHYAALQYWCAKWRGSEERAVSFA
                     QRAAADAPLGSLLTALPLIAWYEHRDTDARSAAFRSPHLVALVDAALADVAAAPSNHPN
                     TAEVRHLLAYFLTRQKRYDAALEQFRLVDGYVNALPWKYWTDPAATFCHWRDRAAHRAG
                     RARRR"
     gene            complement(15422..15802)
                     /locus_tag="IE257_RS08045"
                     /old_locus_tag="GCM10010343_16560"
     CDS             complement(15422..15802)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967191.1"
                     /locus_tag="IE257_RS08045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16560"
                     /product="DUF4440 domain-containing protein"
                     /protein_id="WP_189966069.1"
                     /transl_table=11
                     /translation="MSRETDEVGAAIAGELRLMDPGVRMSQSLVRQLLDPHFVEVGASG
                     RRWTYEEMLAVLPDMDGSAEGGPRYEPSEMTGVLLAPGLVHLTYETVIDGHRARRSSLW
                     RRQGAGAEWQMYYHQATPCPRP"
     gene            complement(15845..16420)
                     /locus_tag="IE257_RS08050"
                     /old_locus_tag="GCM10010343_16570"
     CDS             complement(15845..16420)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982033.1"
                     /locus_tag="IE257_RS08050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16570"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189966071.1"
                     /transl_table=11
                     /translation="MAAEAERPLRADAQRNRDKILAAAVRVFTEQGLEAHFERIAKEAG
                     VGTGTLYRNFPTREALIEAAYRNEVARLCDAVPTLLETMPPDRALHAWTRRFIDYATAK
                     MGMADAMRAVLVAGTNPYADSRRLIQDALTSLMEACTAANAIRSDITSTDMFAALAGIA
                     LTSAGPEQRAQAERLLDLTLDGLRARRE"
     gene            16563..17294
                     /locus_tag="IE257_RS08055"
                     /old_locus_tag="GCM10010343_16580"
     CDS             16563..17294
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-168). E-value: 8.8e-13. Score:
                     40.5. Matches aSDomain:
                     nrpspksdomains_IE257_RS08055_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580355.1"
                     /locus_tag="IE257_RS08055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16580"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189966073.1"
                     /sec_met_domain="adh_short (E-value: 1.6e-35, bitscore:
                     118.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGIEGKIVAVTGAGSGIGEATALLLAERGAKVVLGARRTERLEA
                     LAARIEQAGGQAAWIRTDVTRRTDLAGLVDLARQRYGRLDVLVSNAGVGLISPLDDLRV
                     DDWEEMIDVNLKGVLYGIAAALPVFREQGAGHFVNTVSTAGLRVVPLQSVYAGTKNAVR
                     TISEGLRQEAGDSLRVTVVSPGAVRTDFTERMDPEARERIDRMMETALSPDAVARAIAF
                     AIEQPDGVDVGDIVVRPTAQA"
     aSDomain        16587..17066
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS08055_PKS_KR.1"
                     /evalue="8.80E-13"
                     /label="IE257_RS08055_PKS_KR.1"
                     /locus_tag="IE257_RS08055"
                     /protein_end="168"
                     /protein_start="8"
                     /score="40.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVTGAGSGIGEATALLLAERGAKVVLGARRTERLEALAARIEQA
                     GGQAAWIRTDVTRRTDLAGLVDLARQRYGRLDVLVSNAGVGLISPLDDLRVDDWEEMID
                     VNLKGVLYGIAAALPVFREQGAGHFVNTVSTAGLRVVPLQSVYAGTKNAVRTISEG"
     CDS_motif       16593..16670
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE257_RS08055_0001"
                     /evalue="3.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE257_RS08055"
                     /protein_end="36"
                     /protein_start="10"
                     /score="13.3"
                     /tool="antismash"
                     /translation="VTGAGSGIGEATALLLAERGAKVVLG"
     gene            complement(17358..19094)
                     /locus_tag="IE257_RS08060"
                     /old_locus_tag="GCM10010343_16590"
     CDS             complement(17358..19094)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088719.1"
                     /locus_tag="IE257_RS08060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16590"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_189966075.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.9e-20, bitscore:
                     68.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADALLFNPHTYDPAHFDPETRRLLRATVDWFESRGKRRLIEDYR
                     SRAWLADFLAFSAKEGLFATFLTPATAAGEGESDKRWDTARIAALNEIFGFYGLDYWYA
                     WQVTILGLGPVWQSDNAEARERAAQLLSEGEVFAFGLSEKTHGADIYSTDMLLQPYVDE
                     DGAGGFRATGSKYYIGNGNAAGLVSVFGRRTDIEGPDGYVFFAADSRHAAYHLVKNVVD
                     SSKYVSEFRLDDYPVRAEDVLHTGRAAFDAALNTVNVGKFNLCTASIGICEHAMYEAVT
                     HAHNRVLYGRPVTAFPHVRRELADAYVRLVGMKLFSDRAVDYFRTAGPDDRRYLLFNPM
                     TKMKVTTEGEKVIDLMWDVIAAKGFEKDNYFAQAAIEIRGLPKLEGTVHVNLALILKFM
                     HNHLLNPVEYPEVPTRLDAADDAFLFQQGPARGLGSVRFHDWRTAYDAYAAVPNVARFR
                     EQADALCAFVATVAPDEEQSRDLDFLLSVGQLFALVVYGQLVLEQARLTDLDESVLDEL
                     FSVLVRDFSGHAVELYGKDSATAAQQDWALAAVRRPVVDEARAARVWARVEALSGTYEM
                     AP"
     gene            complement(19173..19745)
                     /locus_tag="IE257_RS08065"
                     /old_locus_tag="GCM10010343_16600"
     CDS             complement(19173..19745)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763505.1"
                     /locus_tag="IE257_RS08065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16600"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_189966076.1"
                     /transl_table=11
                     /translation="MALDHAILVSLLEKPGSGYELARRFDRSIGYFWTATHQQIYRVLA
                     RMEGDGLLAVREVPQQGRPDKKEYSVAGPGRSALAGWLHEPIEPESLRHDLAVKIRGVA
                     FDDPAALVQEVERHHRAHSDRLARYLAGELRDFTGPDAPAPLDAGQELQHVVLRGGIAY
                     ERMTIAWLDDVLATLHRLGGTAPTATA"
     gene            20008..20613
                     /locus_tag="IE257_RS08070"
                     /old_locus_tag="GCM10010343_16610"
     CDS             20008..20613
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970264.1"
                     /locus_tag="IE257_RS08070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_16610"
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_189966077.1"
                     /transl_table=11
                     /translation="MSTAKDLFIIAMDPPPDRSVGQGDLSLALAGAELIDLLDAQAASL
                     DGDRIVPGAQPELHDPLLDEAASALTRRTPYERVDEWLWRRGRDLSAAYQAALEEAGEL
                     TRGRRGLLPFGNDRMEVADTPARRRALGRQEEDEPVLAALASVVGIRSDDPEAEPRPGD
                     EAVTTVLAVVSDAVMELEAVRQRRTIENAAFANIWRGP"
ORIGIN
        1 ggccgctgcg ccattggggt cacagggtgc ggcgccatgc cggggacgga ccgtcaggtc
       61 cccgtagagt gccccgtacc gtcgggaaga actcggaggc cgacccccgg agaagtctgt
      121 gcatgacgct cccgacacct gggcgggccc acccccgcgc tccggtgccg caccactcgt
      181 ccggatgcgc ggcctgagca agcggttcgg cggcacgctc gcgctggcct cggtcgacct
      241 cgacatccac cgcggcagtg tcctcgccct gctcggcccc aacggggccg ggaagtccac
      301 cctcatcaaa gtgctcgccg gggtccacca cgccgacgag ggccaggtca cggtggccgg
      361 gcacccgctc ggcagccacg ccgcgacccg gagcatgtcc ttcatccacc aggacctcgg
      421 tctcgtcccg tggatgacgg tggccgagaa catcgccctg ggcaccggct acccccgccg
      481 cagcggactg atctcctggc ggcggacccg gcagcgctgc gacgaggccc ttcgcatcgt
      541 cgccggccat ctggaccccg acgcccggat ctccggcctc ggacccgccg aacgctcgct
      601 cgtcgccatc gcccgcgccc tcgccacccg ggccgggctc atcgtgctcg acgagccgac
      661 cgccaccctc cccgccgccg actgcgcgcg gctcttcgac gtcctgcacg ccctgcgcga
      721 ccgcgggcac ggcatcctct acgtcagcca ccggctcgac gaggtgtacg aggtcgccga
      781 cacctttgcc gtgctgcgcg acggccggct ggtcgaccgg ggtccgctcg ccggtcacag
      841 cccggaacgt ctggtgcggg cgatcgtggg ccacgtaccc gccgggcccg caccggtcgg
      901 ccgggtgccc ggcgcaccac ccgtcgccgg cacgcccctg ctgcgcctcg acggggtgcg
      961 gaccgcgtcc accgggcggg tcggcctgga cctgcgggcc ggtgagatcc tcggcatggt
     1021 gggcctgacc ggcgccgggc acatggagct gggccgcgcc ctggccggcg cccggccgat
     1081 cctggaaggg cgggtgctgt tggacgggcg cccgtatcac ccgcgttcgg tccacgccgc
     1141 tctcgacgcc ggtgtcggct tcgtggcggc caaccgtcag gaggagggct gcgccgccga
     1201 actgaccgtg cgggagaact tcctggcgaa cccccgggcg tccggcacgc cgaccgcgca
     1261 ctggatcaac ccccgtcgtg agcgcgccga ggccctcgcc ctcatcgacc ggttctcggt
     1321 ccacccccgc aggagcgagg tgccgatcgc caccctgtcc ggcgggaacc agcagaaggt
     1381 gatggtgggc cggtggctcc gggggcacct gcgcctgatc gtcctcgagg agccgaccgc
     1441 cggggtggac gtcggtgcca aggccaccat ccaccggctg ctcgacgacg cgctcggctc
     1501 cggcctgggc gtcctgctca tctccaccga cttcgaggag gtcgcggacg tgtgccatcg
     1561 cgcgctggtg ttcgtccgcg ggagcgtgag cgccgagctg agcggtgcgt ccctcaccgt
     1621 tgccgaactc acccgcaccg cctcggcgat gcccgcgatc accgggacca cgacggaccg
     1681 atgacgacct cgcccccgcc tccgccctcg ccctcgtctt caccgcggtc cctactggac
     1741 cacctgcgtg gccaccacat cggcacctac ggcctgctga tcctcgccgt cctgctgttc
     1801 ctggtcttct ccgtcgtcct tccggacacg ttccccaccc gggacaacgt ctcctcgatc
     1861 ctctccaacc agtccatccc cgccatcctc gcgctcggcg cgacgatccc catcgccacc
     1921 ggcaagttcg acctgtccat gggctacggc ctgggcctgg cccacgtgat ggtgctccag
     1981 ctgatcgtca acacgggctg gccctggccg gcggcctgcc tcaccgtcgt actcggcggg
     2041 gcactggtcg gcgtcctcaa cggcgtcatc gtcgagtacg tgcggatcga ctccttcatc
     2101 gccacgctcg gcaccggcag catgatgtac gccgccaccg gctggatcac cgacggttcc
     2161 cggatcgtcc ccggcccgga cggcctgccc gcctccttca ccggcctcta cgactcccgg
     2221 ttcctcggcc tgcccctccc cgcctactac gtcatcgccc tggcggccgg gctctgggtg
     2281 gtcctggagc ggctgccgct cggccgctac ctgtacgtca tcggctccag ccggcgcacc
     2341 gccgacatca tcggcatccc cagccaccgg tactccgtct acgccttcgc cggatcgggc
     2401 ctggtcaccg gcctcgccgg ggtcctcctc gccgcccagc agcagaccgg caacccgagc
     2461 gtggggctgg actacctgct gcccgccttc gtcggcgccc tcctcgggtc caccacgatc
     2521 aaacccggcc gcgtcaacgc cctcggcacc gtcgtggccg tcgccgtcct cgccatcggt
     2581 ctggccggca tcggccagct cggcgccgac ttctgggcca caccactgtt caacggcgcc
     2641 accctgctca tcgccgtcgg cctggccggc tactccgccc gccgccggct gcgcaccccc
     2701 tagaaaagtc cgtacgcgca ccgcgtcagg agcaccgtgt accccaagga cccgcaccgc
     2761 aggaccatcc tccggaccgc cgccctgctg accgcggccg ccgccctcgt cgccggctgc
     2821 gggggcggcg gcccgtccac cggcgccgcg cccccgaagg cgggctgccc cggcgtcctc
     2881 gccgccgccg gcgcggccgt ggcgcaggcc gagaaggccg acacctcctg gcacggcccg
     2941 accaccggcc ccgcggcggt gcccggcaag tcgatcgtct acgtcgcgca gaccatgacc
     3001 aaccccggcg tcgcgggcgt cgcgaagggc atccaggagg ccgcaaaggc catcggctgg
     3061 cgggtccggg tgatcgacgg ggacggcacc cccgccggga tccaggcggc gctcagccag
     3121 gccatcaccc tggcgccctc gggcatcgtc atcggcggct tcgatcccca gctgacctcg
     3181 cagcagatgg cccgggccga ggcggcgcgg attccggtca tcggctggca cgcggtgggc
     3241 tcccccggcc cgagcgagca ccccaggctg ttcaccaacg tcaccacgaa ggtggaggac
     3301 gtggcgagga tcagcgcgga ctggatcatc gcccggtcga agggcggagc cggtgtcgtc
     3361 ctcttcaccg acgactcgat cccgttcgcc cggaacaagt cggagctcat tcgcaaggag
     3421 ctcgccacct gccccggcgt acggctgctc tcgtacgaga acatccccat cccggacgcc
     3481 gcgagccgca ccccgcaggc ggtctcctcg ctgctctcgc gcttccagga cgagtggacg
     3541 tactcggtcg ccatcaacga cctctacttc gccgacgcgg ccccggccct gcgggcggcc
     3601 ggcgaaccgg gtgcggggcc gcccttcaac atcggcgcgg gggacggcga cccctccgcc
     3661 ttccagcgga tcaacagcaa gcagttccag gccgccaccg ttcccgagcc gctcaaccag
     3721 cagggctggc agatcatcga cgagttcaac cgcgccttcg ccgggcagcc cgccagcggt
     3781 tacgtggccc ccgtgcacat cgccacctcc gagaacagcg acggcgccac gtcctgggac
     3841 ccgtccggtt accgcgaggc gtaccgcagg atctgggccg gctgacggca cggcagaccg
     3901 ggccccggcc ccgcgcggtg cggggccggg gccgggtcgt ggctgctgtt acaggtaggg
     3961 gtcgaagggg atgcccgccg gcttggcctc cgccaggtgg gaggcgaagg agccgtcctt
     4021 caggccgaag tgcgcgctgc cgaaatcggc ctgggtcagc ttgtcccgca gggtcgccgg
     4081 atagcccgac cacccgacga gcgtggggaa ctgccaggtg ccgcggtggt tctcgggcgg
     4141 ctcgtcattc gtgttcgccg cgcggaagca gtgcgtgccg atgccgtcct tgtggtagac
     4201 gatcttgggg tggttgccgt cccagcggat ctggtcgcgc gagtggatgt tgaagtcccc
     4261 gtgggcggag gtcgccacgt acttggcctc gttgccctgg atccacacga ccacgtgctc
     4321 ccagtcgtgg cggtggccgc cgagctcgat gccgggcagg gcctggtcct tctcgaagta
     4381 cagcgcgtag acgacggcgc accagccgtt gttgcaggtc cagcgggagt agccgttggt
     4441 gttggcgagg tccgaggcgt cccggcagtt gccgttgagg gcaccggtgg gcttgagtcc
     4501 gccgttcagc actccggtcg gccctatggc gggtgtcgga tagcagccgt cggtgtcgta
     4561 gtcgtaggcc ggctggtagg tcagctcgat ggcttcggcc ttgccgggga gcgccggggg
     4621 cggcgccgcg aaggccacct gggggacggc gacgaccacc gtgagggcgg cgccgagaac
     4681 cactaatgat ctccgtatgt gacggttcgt ccgcaaaacg ggcctcctgg ccgaccgggt
     4741 gcgaggggtg gcggacgcat cgcgacggaa cgccgtcgac cgacacgccg ggagcatcat
     4801 tcgcgaaccg gtgtggcgcg gcaagaggcc gggcagactt ggtcccttgc gcgaccgaag
     4861 gccggaaata ccttgtacgc aagggaaatt gacagaatgt cagatatgag cgagcagctc
     4921 gggcaggcgt acgggcgaac gccgccgccg ccccgggcgc aaccgggagc ggcggcgggg
     4981 cgtcacacgg tcatcaccag aggacgttca tcaggatgat ggccatgagg tcgaggagga
     5041 tgacggcgac gacggcgccg atcatggtcc aggccttgcg cgattcgtcc atgcgtacga
     5101 gtcacctccc ggctcgggcg gacccgggcc cgccgtgcgg tcccggtccg gggccgcacg
     5161 gggaactcgt ccgcctccgg ccatgatgac ccggttccgc acgcggcaca ggtcggcggg
     5221 gcggccccct caggcgaccc aggtcgcggt catgcccacg accgccgagc cgtcctggtc
     5281 gaccagcttg ttcccggtga aatcacgggc ccactcggag gtctggatgc ggaacgcggg
     5341 ccgctcggcc gtcagcgcct ccatgacgga ctcggccgcg ccggccgggg tctgcgcacc
     5401 gttcaggaac tggccgaccg tgcgctcgac gtagtggcgc agcgcgtcgg agtagggacc
     5461 ggccgcggcg atgcgggctt cgaggtcgag gtcgatgttg ttcacgaact cggtcgccac
     5521 ggcgcccggc tcgatcacgg tgacgcccac cccgacggca cccgcgacgg gggccaggct
     5581 ctccatgtac ccctcgacgg cgaacttggc ggcgcagtag gcctcattga agggctggcc
     5641 cacgacgccg ccgacgctgg tgaccgtgat cagacggccg ccggtggccc gcaggtgcgg
     5701 cagggcggcc ttggagacgt tcagcacgcc gaagaagttg acctccatga cctcacggac
     5761 gtcggcgacg gtttcgagct ccagggtgcc cacgtgcccg gcgccggcgt tgttcacgac
     5821 ggcgtccagt cggccgtagt cggcgatcac gccttccacg gcggcggcga cggaggcctc
     5881 gtcgacgacg tcgagctgcc ggatgtcgag tgcgacgccc gcgtcgacgg cggccttgcg
     5941 cagggcgtcg gcgcggccgg tgtcacgcag ggtggcgacc gtcctccagc cggcccgggc
     6001 ggcggcgatc gcggcggcca ggccgatgcc ggaggaggtg ccggtgatca ggacggtgcg
     6061 ggtggaggtg ccgggggtgg cggggagggt cgacatgacg gggcctttca ctacgggtga
     6121 tttatgtgcg tgcacacaca ccataaaatt atgtgcgtgc gcacgcaagc tctagactgc
     6181 cgacatgccg aagaagctca ccgaagccga gatgccgacg gccgactacg ccttctacgg
     6241 gctggtgtgg gccggcaccg tgatgaccga tcgcgtcgac cgggccctgg tgaaggccca
     6301 cgaccttccc gtgtcctggt tcgaggtcat gctgtggctg gcctccagcc ccgagccggt
     6361 gcccgcttcc gtcctcggca acagcaccct gctcagccgc agccaggtct cccgcgtcgt
     6421 ggacgccctg cagacccgcg gcctggtcac ccgcacaccc tcggcgcgcg acgcacgatc
     6481 ggtggaggtc tcgctcacgg aggcgggacg tacggtgttc gccgaggccg acaccactcg
     6541 gcgggaggcc ctcgccccgg tcttcaccga gctcctcgac gagcaggacc tggaggcgct
     6601 gggcaccgtg tggcgcaagc tcaaggccgc gaaggccgcc caggccgagc aggagcgcac
     6661 ccggtagacc ccgtccgccc gccacgggcc cccgtcaggc ggatcgaccc tcgggggtga
     6721 gggtggcggc tgccgcgaag agacgggcgc agcgctgcgt catggcctcc ggcgtctgct
     6781 ccgggtgctt gacccaccag cggacgaggg tggcgaccag gtcccgccag acgtacttga
     6841 gcgcgtccgc gtccagcgga tcggtggagc cggccgcgct cagcagttcc gccgtgccgc
     6901 ccgcggccag ccggtcgatg gctgcccagt actccgaggc cctgcgggcc gcctcaccac
     6961 cgggcggcag ggtggtgtcg tagagcacga accacgcctc ccgccggccc tccagcgcgg
     7021 tgaagatgcc gtggaggacg cgcagcggcg tgtgcggcgc ggtcccgccc tcacccatcg
     7081 cctcgcggac ggcgcccagc agccggtccc ccaccgggac caggcaggcg acgtacaggt
     7141 cctccttgct gccgaggtac tggtgcagca gcgttttggt gacgcccacg cgtgcggcga
     7201 tcgcggggag cgaggcggcg gcgtagccat gcctgccgaa ctcctccgtg gccgcctcca
     7261 gcatctgccg gcgacggcgc tcccgcggga ctcccttggt gccggctttc gaggaagggg
     7321 ttgccatggg ccaatattat cagtaggtaa tttaccgcta ggtaaattac ctcgacccct
     7381 ggagcgccgc catggccggc accacctcgc agcccacgtc ccgcacccgc tcctggtggg
     7441 gctggggctg gacggacgcc catcccgacg acgcggaatg caccgcgatg ggcgccctgc
     7501 tccccggcac cctcggccgc ccgctccccg tgccccgcgt gagcgacctg gagatcgccg
     7561 gtcccgccgt cgaacccccg cccagcctcg cccacctggt gagcaccgat cgcgaggacc
     7621 gcgccgccca ctccatgggc aaggcgtacc gggacgtggc gcgcgccctg cgcggccgcc
     7681 ccggccgtgt ccccgacctc gtcgcccgcc ccacggacga ccgggacgtg gccgatctgc
     7741 tggactgggc cggtgaacgg caggtcgccg tcgtcccgta cggcggcggg tcctcggtca
     7801 ccgggggcgt cgagtaccgc ggcgacgccc accgggccgt gatgtccctc gacctgacgg
     7861 ccatgggccg cgtcctggag gtcgacaccg agggccgggc ggcccgcatc caggccggca
     7921 ccctcgggcc gagcctggag gaccagctgc gaccgcacgg cctcaccctg cggcacttcc
     7981 cgcagagctt cgagttctcc accctcggcg gctggctcgc cacccgggcc ggcggtcact
     8041 acgccaccgg ccggacccac atcgacgact tcgtacagtc gctgcgcgtc gtcaccccgg
     8101 ccggcaccag cagctcgtgg cggctgcccg cctccggggc cggcccctcc cccgaccgcc
     8161 tgttcctggg ctccgaagga gccctcggcg tcatcaccga agcctgggtc cggctgcagg
     8221 aacgcccgcg ccacaaggcc tccgccgcgg tcgccttcgc ggacttccag ggcgcgctcc
     8281 gggcggtgcg cgcccttgcg cagtccgacc tctcccccgc caactgccgt ctgctggact
     8341 ccggtgaagc cgcgctctcg ggtgcggcgc acgacggcag ctccgtactg gtgctcgggt
     8401 tcgagtcggc cgacgaaccg gtggccgccc ggctcgaacg ggccgtcgcg ctggcccgct
     8461 cgcacggcgg ccggtacggc ggagcggacg gagccgtcgg cgaccgggac ggggccccgg
     8521 acggcgaggg ggccgtgagc gcgtggcgct cggccttcct gcggatgccc tacctccgcg
     8581 acggtctggc caggatgggc gcggtggtgg agaccttcga gacggcggcc acctgggacc
     8641 ggatccccgg gctgatcgac gaggtacgca gggaggtcgg tgcggcggcg gtcaaggcaa
     8701 ccggacatcc cgcgaccgtc aactgccgtc tgacgcacgt gtatccggat ggtgcggcgc
     8761 cctacttcac cgtcctcgcg gccggccggg ccggtgacga ggtggccgtc tgggacgaac
     8821 tcaaagccgt cgcgagtgag gtgctgcacc gccaccgggc caccatcacc caccaccacg
     8881 cggtcggccg ggaccaccgc ccgggctacg accgccagcg ccccgagccc ttcgcactcg
     8941 ccctgcgggc cgcgaagggg gcgctcgatc cgcggggcat cctcaacccc ggggtgctcg
     9001 tggactgatc ggggccgggc gcccggacac cccgaagggg ccgggaccgt cgggcgacgg
     9061 ccccggcccc ttcggccgga gttcggtggg cgtccgctca gacgcggtcg gccgcgatca
     9121 ggacgtactg gaaggagccg tccttgtagg actcgatgaa cgcctcctcg atgccggtca
     9181 ccagggagga cgtggcccgc agctcccagt acggcagggt ctcgggggtc aggtcgatga
     9241 cggcctgcgg tacgagacgg ttgtcggcca tcgcgcgcag gtactcgcgg cgggagtgga
     9301 tgttgcactc gaagtgcgcg ttgatctggg agacccactt cgagggctgg ccgtaccgcg
     9361 ggttccagca gccggtgatg gtcacgtaac ggccgccgac cgcgaggact cgggagtgct
     9421 cggcgaacag gtcctgcagg tcgacgtaca tgctcgactc gttgttccag gagcccgcgg
     9481 cctgcccggt ctcgaagggc gtgctgagca tgttgcagac gcgggcccgg acgtggtccc
     9541 cgatgccgag ttcctcggcg cgccggttgg cgaagtcggc ctgcttggcc gacagggtca
     9601 caccctccac cttgcacccg aagcgctggt gggccatgac catcgaaccg ccgcggccgc
     9661 agccggcgtc gacgagggtg tcgtcgcgct cgatgtggcc gaggtgctga aggagcagtt
     9721 cggcctgcgc cgactccagg cggtggagct cggcgatcag cttcttctca taggcgctgt
     9781 cggcggtgtc gccgagagcg gcgtggtcga tgtcgccgat gccgtagtgg tggtggtaaa
     9841 ggccgtcgac gtcgccgagg cggaggttca cgggcctggc ttcgtggtcc cagtaacggg
     9901 cgatatcccc ctggtagggg gtcgccgggc cggggatgaa cacggaggag gtaccggcag
     9961 cggtggtgag atcggtgcta gtcatggaca attcccatct ttaccagaaa tcgggcaggc
    10021 tgtagcgata ggtgttggtc tggtgccagt agtggttgcc gtcgacccat acggccaccc
    10081 cccgcaggaa gcgctgcacg ctcgggacgg ggcaggcgag ggccagctcg gcggccgcgg
    10141 cctcgaagtc gcgcatgagg tcgttgtgga cctccaccgc cttcaggtag gcgtcctggt
    10201 cggagcactt ctcgcgctcg gcgatcacca cgggaaggtt caaatgcctt ccggggccgg
    10261 ccagttcctt ggtgtacgaa tacaggtcgt tgacgatggt ggtggcgttg ccggcgagcg
    10321 cgatgacccg ctgcatggcg ggctgcgcgt ggaggtccgc cggcagttcg tagccgccga
    10381 ccgtgtcggt gatggtggga caggggcgga agttgttgaa ctgccgcatc gccaggtact
    10441 cccacacctc cgggacgtac tccgtctgcg cccaggcccc ttcggccagg tagcccatgt
    10501 gcagtcgggc catgtcgtgc cggtaccggt cggcctggga gggggtgctc gcctggacga
    10561 agtactccat ggcggagcgg taggcacgcc tgggggcgtc cgagagcagc gacgcctccc
    10621 actgcggcgc gtactccttc gtcgtgtgca gcgggtcgag ggctgtgtgg gccagcagca
    10681 ggcgcccgcc gaggccgatg ggcgacccgc cgtggtcctc gcagtagcag tcgtcgaccg
    10741 cgttctcggc gaccatcagc cgggtggcga gcatcaggtg gtcgatgctg ggggcgtccg
    10801 ggtggcaggc gaccatgtag cgcccgacgg agaagccgtc gaactggtcc tcccagtcct
    10861 ccgggtacaa ggagacctcg tccagcgccc aggccttgat cctgcggctg agctcctcca
    10921 cccgtaccgg atcggggtcc ggcaccgggt ggtggtagag gccggggatc ggacggcccg
    10981 cggccgggcc cgacgcgtcg ggcccggccg gcgcggagcc cgcggcggcc gcggcctcgc
    11041 tacgggccca gtgcaggctc tccgtcccca gtccgctggg cccgcgcagg atccgttcca
    11101 gggcggcggc gctcggctgc ggtgcgtcca cagcggccgc actcccgtcg ggtacgggta
    11161 cggggaccgg tacgggtgcg tgcgcgattg cgggcgtcag tacgggcggc cccgtgggca
    11221 gggcgggcgg ggacggtggc gagggctcga cgggcccggc gccggcggcg ggttcgacac
    11281 cggcggccag ggcgttggcg aggatgtggg ccccgaagga ggccgccgcg gcaggaagac
    11341 tcgactgcag gggggaaggc ccaggatcgg gcatccgtaa ctcctaggtg acgtaagtgg
    11401 gttgtcccgg atcccgggca tgctcggcgg gccaggacag gccgggtcct ggctgtcgtg
    11461 gccgtcgggc tggtcctctt agtcccgcct gcgggcgatc tgcacgttct ccagcacacc
    11521 gagcgcgtcg ggcaccagga tggcggcgga gaagtaggtg gtgaccaggt aggagatgat
    11581 cgcctgttcg ctgatcccca tgaaacggac cgacagaccc ggctcgtact cctccgggat
    11641 tccggtctga cgcagaccga tgacgccctg gttgtcctcg cccgttcgca tgacgagcac
    11701 cgagctggtg ttctccttgc tgatcgggat cttgttgcag ggcaggatcg ggaccccgcg
    11761 ccaggccggg acctgctgcc cgccgacgtc gacgtggtcc gggtagagcc cgcgggcgtt
    11821 gaactcgcgc ccgatcgcgg cgatcgtcct ggggtgggcg aggaagaact tggagccgcg
    11881 gcggcggcag aggagctcgt cgaggtcgtc cggggtgggc gggcccgagt gggtctggat
    11941 ccgctgcttg aaggcggcgt tgtggagcag accgaagtcc cggttgttga tcagctcgtg
    12001 ctcctggcgc tcgcgcagcg cctcgatggt cagcctgagc tgctcctcgg tctggttgtg
    12061 cggcccgttg tagaggtcgg cgaccctcgt gtgaatgcgc agcacggtct gtgcgatgga
    12121 gagctcgtac tcgcgcggct tgagttcgta gtcgacgaag gcgccgggca ggtccgcctc
    12181 accggtgtgg ccggcggaca tcgcgatctc ggcctcgccg tgccggttct ggcgctgctg
    12241 cgggagcatg ctgaaccggt cgatgtgggc ctggagttgc ggcgccgcgg cgagcacgga
    12301 ggcgaagtcg ccgcgggaga gggtgagcag gatgccgggg gtctcggcgg tggccgtgta
    12361 gtcccaggtg gcgtcggcgt ccagcagggc gttctcgccg aaccggtcgc cgtccgcgag
    12421 cacggcgacg gcgacgtcgt caccgtactt gccgacggag gtctggctga tccggccgtg
    12481 ggcgatcaga tggatctggt cggcgggggt accgcgctcg acgatcactt caccggcgcg
    12541 gaagtcgcgc tggacgcaac ggccggcgag agcggtcagc acctcgtcgt cctcgaagcc
    12601 gcgcagcagg gccagttctc cgagttcgcg cgggatcacg cggacgttcg cgccgtcctg
    12661 gacgaactcg atggtcccgt cgcccacggt gtacgtcagt cggcggttga cccggtaggt
    12721 gccgcccttg gtctccaccc aggggagcat ccgcaccagc cagcgggagg tgatctcctg
    12781 catctgcggg gcggacttgg tcgtactggc aaggttgcgg gcggccgccg tgctcaggct
    12841 ggactgccgc ggcggctcca gctgcgcttc cgggctggtg tcaacggtca tcggtcgagc
    12901 tctccttcgt aagggtggtg atcggcgcgt gcgcgcgtca ccggagaacg aggaaaaaga
    12961 ggggcgaata tccgggaatc cgtccagatc cgtgggaaca gtaacggccg gtacgcccac
    13021 ttgagcctga aaaccgttgg cgttacctcg atgcggtgat cttgtccggc aggtggtttg
    13081 ccggggttat ggacgatatt cggccttgct cacgaacacg gccgaaaagc ggtgcggcga
    13141 acggcccctc gggccacttg cacctgctcg cgaggtaggg agtgtgcgcc tcggggtgcg
    13201 cggacgatta ctctgccggg gaaccgaaat gatcacgttt gcgtcttcgg tcgcacatgg
    13261 ccggccagga agaggagaac ctgacgtgaa gacccagggc gcatcaccgt cccgccgcgc
    13321 actgctgacc gtgggagcgg gggcggcgct ggccgccgcc ctgccggtgg gggcggcccg
    13381 tgccgcgtcc cggcacggcg agggagaggt cgtggcgcga ctgcgcgaac tggaacgtga
    13441 gtacggggcg cggctggggg tgtacgcacg ggacacggcc accggacgca ccgtggtcca
    13501 ccgggccgac gaactgttcc ccatgtgctc cctgttcaag acggtcgccg cggccgccgt
    13561 gctccgggac ctcgaccacg acggcgccca cctcgcgaag cgcatccact acacgctcca
    13621 ggacgtcacc gacgcgggcg gcggatcgat cacggaacgg cccgagaaca tcgcgggcgg
    13681 cctgaccgtg gcggaactct gctccgccgc catcgcccag agcgacaacg cggccggcaa
    13741 tctgctgctg cgcgagctgg gcggccccac cgcggtcacc cgcttctgcc gctcgctggg
    13801 cgaccgcacc acccgcctcg accggtggga gcccgagctg aactcggcgg agccgtcgcg
    13861 ggtgacggac accagcagcc ctcgcgcgat cggacggacg tacgcacggc tcgcgctcgg
    13921 cgacgcgctg gactccgggg accgggaaca gctgaaccgg tggctgctgt ccaacaccac
    13981 cagtggcgac cgcctgcggg ccggcctgcc gaaggactgg gccgtcgcgg acaagacggg
    14041 cgccgggtcg tacgggacga acaacaacgt gggcatcgcc tggccgccgg aacgccctcc
    14101 ggtggtcctg gccatcatgt cgacccggcc cgaaccgacg gcgccgcgcg acaacacgct
    14161 gatcgcccgc accgcgaagc tgctggcgga cacgctcgtc tgacgccggg cctgatccgc
    14221 aggccgctcg aacgcttcag gatcctgccg ggtcggcgcg gttgtcacat ccggcaggtc
    14281 cgttcggtct ctgctacgga aggcgacgac cgaaggggat cgtcgtcgcc gtggcggtcc
    14341 tcttctaccg ccgcaccacc gtcgatgagc cgggcgggac gtcgtcccgt gccgcccgta
    14401 ggtcggggct tcttccgcag tccaggcagc acaccggccg ggcggcgccc gaccccgagc
    14461 tggagcgggc ggctgccgca gccgcccggg gcagttggga gccggccgcc cggttgatgg
    14521 ccgggaccag ggaacgcgcc gactgggcac gccgctcctc ctacgccgcc accctcggct
    14581 cccaccgagc cgcgcgcccc gacagctggc tgcacgcgtg ggaggccgcg gccgggccgg
    14641 acgacgccga cctcgcgctg gtgcgggcga aggcgatggt caacctggcc tggcaccggc
    14701 gtggcggcgg ctgggcgaag aacaccagcg ccgagcagtt cgccggattc cacgccaccc
    14761 tggcccgggt gccgcaggag aacgcacgcg cggccgagtt gaacccggag gaccccacgc
    14821 cctacgtgaa cgagatatgg gcggggctcg gcctcggcta cgacgaggag ggcatgcaac
    14881 ggatctggaa ggagatcacc acccgcgacc cgcaccacta cgacgcgcac tacgcggcgc
    14941 tccagtactg gtgcgcgaag tggcgcggct cggaggagcg cgccgtgtcc ttcgcccagc
    15001 gggcagcggc cgacgcaccg ctcggcagcc tgctcaccgc gctgcccctg atcgcctggt
    15061 acgaacaccg tgacacggac gcgcgttccg ccgccttccg gtcaccccac ctggtggccc
    15121 tggtcgatgc cgctctggcc gacgtcgccg cggcgccctc gaaccatccg aacacggccg
    15181 aagtacgcca cctgctcgcc tacttcctga cccgccagaa gcggtacgac gcggccctgg
    15241 agcagttccg tctggtcgac ggctacgtga acgcgctccc gtggaagtac tggaccgacc
    15301 cggcggcgac gttctgccac tggcgcgacc gcgcggccca ccgcgccggc cgagcccgcc
    15361 ggcgctgaac ccgccaccgg cccgacgtcg gccgacgccg gtcggcctcg gagggccccg
    15421 cctacggcct cggacagggg gtggcctggt ggtagtacat ctgccactcg gctcccgcac
    15481 cctgccggcg ccagagcgaa ctccgccgtg cccgatgtcc gtcgatcacg gtttcgtagg
    15541 tgaggtgcac cagcccgggt gccagcagga caccggtcat ctccgagggc tcatagcgcg
    15601 ggccgccttc cgccgaaccg tccatatcgg gcagcactgc gagcatttcc tcatacgtcc
    15661 accgccggcc cgaggcgccc acctctacga agtgcgggtc gaggagttgc cggaccagcg
    15721 actgcgacat gcgcacgccg gggtccatca gacgcaactc acccgcgatc gctgcgccca
    15781 cctcgtcggt ctctctgctc atacgggcat cttcgtcgag gcgaccgggg caaccgcaac
    15841 cgggttactc ccgtcgggct cggaggccgt ccagggtgag gtcgaggagg cgttcggcct
    15901 gggcgcgttg ttcggggccg gccgaggtga gggcgatgcc ggcgagggcg gcgaacatgt
    15961 cggtcgaggt gatgtcggac ctgatcgcgt ttgcggcggt acaggcctcc atcagagagg
    16021 tgagggcgtc ctggatcaac cggcggctgt cggcataggg gttggttccc gccacgagaa
    16081 cggcccgcat cgcgtcggcc atgcccatct tggccgtggc gtagtcgatg aagcggcgcg
    16141 tccaggcgtg cagggcccgg tccggcggca tggtctccag gagggtgggg acggcgtcgc
    16201 acaggcgggc gacctcgttg cggtaggccg cctcgatcag ggcctcccgg gtggggaagt
    16261 tgcggtagag ggtgcccgtg cccacaccgg cctccttggc gatgcgctcg aagtgcgcct
    16321 ccaggccctg ttcggtgaac acgcgcaccg cggcagccag gatcttgtcc cggttgcgct
    16381 gcgcgtcggc cctcagcggg cgttctgcct ctgcggccat caacagctct cccctccttc
    16441 cgacttgccc cgcttgttaa gtggaggagc ctccgcttag tctgagttga agtggcggcg
    16501 cctccacttt cactctaggg catgcatcgg cctgcccgtc ctcttccgaa gggactcccg
    16561 ccatgtcggg aatcgaaggc aaaatcgtgg ccgtcaccgg cgcgggcagc ggcatcggcg
    16621 aggccaccgc cctcctgctc gccgagcggg gcgcgaaggt ggtcctcggc gcacgccgca
    16681 cggaacgcct ggaggctctg gccgcccgga tcgagcaggc cggcggtcag gccgcctgga
    16741 tccgtacgga cgtgacgcgg cgcaccgacc tggcgggcct cgtcgacctg gcacggcagc
    16801 gctacggcag gctcgacgtg ctcgtcagca acgccggcgt cgggctgatc tccccgctcg
    16861 acgacctgcg cgtcgacgac tgggaggaga tgatcgacgt caacctgaag ggcgtcctct
    16921 acgggatcgc ggcggccctc cccgtcttcc gggagcaggg ggccggccac ttcgtgaaca
    16981 ccgtgtccac cgccggactg cgcgtcgtac cgctccagtc ggtgtacgcg ggcaccaaga
    17041 acgccgtgcg cacgatctcc gagggcctgc gacaggaggc cggggacagc ctgcgcgtga
    17101 ccgtcgtatc gcccggcgcc gtccgtacgg acttcacgga gcgcatggac ccggaggccc
    17161 gggagcggat cgaccggatg atggagaccg ccctgtcgcc ggacgcggtg gcccgcgcca
    17221 tcgccttcgc catcgagcag ccggacggtg tcgacgtggg cgacatcgtc gtacgtccca
    17281 ccgcgcaggc ctgacggcag ggggaccggc tccggccggc gcgagcccgc cggcgccggt
    17341 cccccggaac cgcttcccta cggggccatc tcgtacgtgc cggacagcgc ctcgacccgt
    17401 gcccagacgc gcgccgcgcg cgcctcgtcg acgaccggac gccggaccgc ggcgagcgcc
    17461 cagtcctgct gggccgcggt ggcggagtcc ttgccgtaca gctcgacggc gtggccggag
    17521 aagtcgcgga cgagcacgga gaacagctcg tcgagcacgg actcgtccag gtccgtcagg
    17581 cgggcctgct ccaggaccag ctgtccgtag acgaccagcg cgaacagctg gcccacggag
    17641 agcaggaagt cgaggtcacg gctctgctcc tcgtccggcg cgacggtggc cacgaacgcg
    17701 cagagggcgt cggcctgctc gcggaaccgg gccacgttcg gcacggcggc gtacgcgtcg
    17761 taggcggtcc gccagtcgtg gaagcgtacg gagcccaggc cgcgggccgg tccctgctgg
    17821 aacaggaagg cgtcgtcggc cgcgtcgaga cgggtcggca cctcggggta ctcgaccggg
    17881 ttgagcaggt ggttgtgcat gaacttcagg atcagggcga ggttgacgtg gaccgtgccc
    17941 tccagcttgg gcaggccccg gatctcgatg gccgcctgcg cgaagtagtt gtccttctcg
    18001 aagcccttgg cggcgatgac gtcccacatc aggtcgatga ccttctcgcc ctccgtggtc
    18061 accttcatct tcgtcatcgg gttgaagagc aggtaccggc ggtcgtccgg gccggcggta
    18121 cggaagtagt cgacggcgcg gtcgctgaag agcttcatcc cgaccaggcg gacgtacgcg
    18181 tcggccagct cccggcggac gtgcgggaag gcggtgacgg ggcggccgta gaggacgcgg
    18241 ttgtgcgcgt gggtgacggc ctcgtacatc gcgtgctcgc agatgccgat ggaggcggtg
    18301 cagaggttga acttgccgac gttgacggtg ttcagggcgg cgtcgaaggc ggcccggccg
    18361 gtgtgcagga cgtcctcggc acggaccggg tagtcgtcga ggcggaactc gctgacgtac
    18421 ttggaggagt cgacgacgtt cttcaccagg tggtaggccg cgtgacggct gtcggcggcg
    18481 aagaagacgt agccgtcggg gccctcgatg tcggtgcggc ggccgaagac cgagacgagg
    18541 ccggcggcgt tgccgttgcc gatgtagtac ttggagccgg tggcgcggaa tccgccggca
    18601 ccgtcttcgt cgacgtacgg ctgcagcagc atgtcggtgg agtagatgtc ggcgccgtgg
    18661 gtcttctcgg acaggccgaa ggcgaacacc tcgccctcgg agaggagctg cgcggcgcgc
    18721 tcgcgggcct cggcgttgtc gctctgccag accggaccga ggccgaggat ggtgacctgc
    18781 caggcgtacc agtagtcgag gccgtagaag ccgaagatct cgttcagggc cgcgatccgg
    18841 gcggtgtccc agcgcttgtc ggactccccc tcgccggcgg cggtggccgg ggtgaggaag
    18901 gtcgcgaaga ggccctcctt cgcggagaac gcgaggaagt ccgccagcca cgcgcgggag
    18961 cggtagtcct cgatcagccg gcgcttgccg cggctctcga accagtcgac ggtggcgcgc
    19021 agcagcctgc gggtctcggg gtcgaagtgc gccgggtcgt aggtgtgcgg gttgaagagc
    19081 agggcgtctg ccatggaggt tcaccttccg aggggttggg gtcgggcgcg tggaggggcg
    19141 atgcggcggg tgcggcggtg cggccgtgcg gttcaggcgg tggcggtcgg cgcggtcccg
    19201 ccgagccggt gcagggtggc gaggacgtcg tcgagccagg cgatcgtcat ccgctcgtac
    19261 gcgatgccgc cgcgcagtac gacgtgctgg agctcctgac cggcgtcgag cggtgcgggg
    19321 gcgtccggcc cggtgaagtc gcgcagttca ccggcgaggt agcgggccag ccggtcgctg
    19381 tgcgcccggt ggtgccgctc gacctcctgg acgagcgctg ccgggtcgtc gaaggccacg
    19441 ccgcggatct tgaccgcgag gtcgtggcgc aggctctcgg gttcgatcgg ctcgtgcagc
    19501 cacccggcga gggcggagcg gccggggccg gccacggagt actccttctt gtccggccgg
    19561 ccctgctgcg gcacctcgcg gacggcgagc agcccgtcgc cctccatgcg cgccaggacg
    19621 cggtagatct gctggtgggt ggcggtccag aagtagccga tggaccggtc gaaccggcgg
    19681 gccagctcgt agccggagcc cggcttctcc agcagggaga cgaggatcgc gtggtcgagc
    19741 gccatgccac gatctttcta tgcaactcgt tgcatagaca agcggcagtg ctcaggtgag
    19801 acgcggctca cccgctcccg ctcctcgacc gcccggcggc tgtgtcggcc agccgctgct
    19861 ggacgagtgg gcctaccggg tggatccggg aaccggaagg gcgtcgcggg cgttggtgcg
    19921 accataggaa ggtgatcagc cggtcccacc ggtcggctgg cccccgccgg tatccgcgcc
    19981 ttccgatgac tccgagggga gccgttcatg agcacggcga aagacctgtt catcatcgcg
    20041 atggacccgc cgccggaccg ttccgtcggg cagggcgacc tgtcgctcgc cctcgcggga
    20101 gccgagctga tcgatctcct cgacgcgcag gccgcctccc tggacggcga ccgcatcgtg
    20161 ccgggcgcac agccggaact gcacgacccc ctgctggacg aggccgcgtc ggcgctcacc
    20221 cgccggacgc cctacgagcg ggtcgacgag tggctgtggc gccgtggccg tgacctgtcc
    20281 gcggcgtacc aggccgctct ggaggaagcc ggtgagctga cgcggggacg gcgcggcctg
    20341 ctgcccttcg ggaacgaccg catggaggtg gccgatacgc ccgcccgccg ccgggcgctg
    20401 ggccgccagg aggaggacga gcccgtcctc gccgccctcg cctcggtcgt gggcatccgc
    20461 agcgacgatc ccgaggccga accgcgcccg ggcgacgagg ccgtgacgac cgtgctggcc
    20521 gtcgtcagcg acgcggtgat ggaactggag gccgtccgcc agcggcggac catcgagaac
    20581 gcggcgttcg ccaatatctg gcgcggcccc tgaggcccgc ttccagggcg gcgtcgcgca
    20641 ggtcgagggc gtgaggacct cgttctggtc ggagcggccg aagccgcgcc ggtcgtcacc
    20701 gcgtacgccc gggctgcccg actttcctta tggtgcacgg gtgttggcac gagagcggac
    20761 gggcccgatc accgcgcccg tcgccgggcg cgctcggccg cgcgcgctcg gccgggcgcc
    20821 gtcagccggc gtcgaggacg aggtcggcgc ggtggcggcc caggccgacg agccgggcgt
    20881 tgggttcgtc cgagcgggcc acccacgcac gcgcgtgcgc ggggtccttg ccgtgccgca
    20941 cgtgacggtc gatcagccgg tccaggcgca ggtcctcggc gggggcgagg taccaggcct
    21001 cgtccagcag tggccgtacc gaggcccact cccccgcgtc gtgcagcagg tagttcccct
    21061 cggtgatcac caggggtacg tccggggcga cggggatgct gccggcgatc ggctcctcca
    21121 gcgagcggtc gaaggcgggc gcgtacaccg tgggcccctg cggtgcccgc agccgccgca
    21181 gcagggcgac gtagccggcg gcgtcgaagg tgtccggggc gcccttgcgg ccggcgcggc
    21241 ccagccggtc caactcggcc ccggcgagat ggaagccgtc catcgggacc accacggccc
    21301 gatccggccc gagcgcgtcc gcgatccggg cggccagtgc cgactttccg gctcccgggg
    21361 gcccggcgat gccc
//
