LOCUS       NZ_BMVL01000002        28428 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000002
VERSION     NZ_BMVL01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 840996)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 545323
            Orig. end                         :: 573751
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28428
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..28428
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28428
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:18428]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18428
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(42..62)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.36"
                     /tool="antismash"
     misc_feature    125..135
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(264..668)
                     /locus_tag="IE257_RS06815"
                     /old_locus_tag="GCM10010343_14040"
     CDS             complement(264..668)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="IE257_RS06815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14040"
                     /product="ATP-binding protein"
                     /protein_id="WP_189965669.1"
                     /transl_table=11
                     /translation="MPLLPILHLELNGPGAAGAARSAARGLLEPSEAGDRAFTAVARDT
                     ALLVISELVTNAVRHTSGGCVLDMHRTPDGGLDVDVSDTSSAEPRLRDPGQQGEGGWGW
                     HLVNRLGKEVDVRHLAGQGGKTIHVHLDRT"
     gene            878..2095
                     /locus_tag="IE257_RS06820"
                     /old_locus_tag="GCM10010343_14050"
     CDS             878..2095
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031581.1"
                     /locus_tag="IE257_RS06820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14050"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_229920166.1"
                     /transl_table=11
                     /translation="MSAEKTVPAVPQCLGAVLAWVLERSHGASALELPGVIGEAARRLG
                     ISRTRLYLADLQQRRLLPLPRPDLTAEERKGLGVEGSLAGLAYRTQEVQSTRGGDTTWF
                     PMVDGIERIGVMQTLTSGPDSGLLEASRALASLATLLVVSKSTHHDPLVQGQRVRPMTL
                     QAELLWAFLPPRTIGTALATSSAVLEPAYDIGGDAFDHCFIDGVLHLTLVDAMGHDLAS
                     GGASGAALAACRSTRRSSGDLPDIVSAIDRTLAQWIPDRLMTAVIAELDTAQGDFTWIN
                     CGHPPPLLIRDGHVLQNALERPPHLPLGFGFHTPVPPAQEHVRLQPGDRVLMYSDGITE
                     ARSPEGDLFGEERLADTVIRSTASGDNAPEALRRLVQNLLSHHQHHLRDDATILLIEWH
                     PFPRTH"
     gene            2314..2643
                     /locus_tag="IE257_RS06825"
     CDS             2314..2643
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS06825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189965671.1"
                     /transl_table=11
                     /translation="MSGRRLSHEEKMELAGIESALCDEPSFRVLSSEYGLVPAHGKRRR
                     AGSWSLPAALWCAVFLSLALLVLATATSAPPLIAAFAVSYAMTSGLLVALVRQWCARHP
                     DGPEN"
     gene            complement(2660..2914)
                     /locus_tag="IE257_RS37970"
                     /old_locus_tag="GCM10010343_14070"
     CDS             complement(2660..2914)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037170.5"
                     /locus_tag="IE257_RS37970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14070"
                     /product="VOC family protein"
                     /protein_id="WP_229920167.1"
                     /transl_table=11
                     /translation="MVLRSAGAAVARLNSGPVEAGAEQSYDRPRWLVHFKVPDLDVARE
                     RAVAQGATQVPGPADADRRSQVALRDPQGALFTLGRATE"
     misc_feature    complement(3532..3546)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    complement(3876..3892)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.84"
                     /tool="antismash"
     misc_feature    complement(4649..4662)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     gene            4649..5416
                     /locus_tag="IE257_RS06835"
                     /old_locus_tag="GCM10010343_14090"
     CDS             4649..5416
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032431.1"
                     /locus_tag="IE257_RS06835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14090"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_229920168.1"
                     /transl_table=11
                     /translation="MDPVHPDDLPSGGGGPLPQDGEEGRLHSVFSGAVDGVASHDVPAA
                     LCRACVDLMDVTGASVSLSGEDPDIRTLWWSSDEVAGRLAEAQYTLGDGPCVTALTHLA
                     PVLAADLTRGPDAARWPVFSQQAVELGVRAVFSLPLNHSAVAIGTLDLYRDRTGPLTES
                     DRSFAFPAADAITTALLALQAQDSGDGLGASWLDEAETDHEEVHQATGMIMVHLGVDPH
                     HALARLRAYAFSHGQTVTEAAFDVIAGRIRFRD"
     gene            5463..6197
                     /locus_tag="IE257_RS06840"
                     /old_locus_tag="GCM10010343_14100"
     CDS             5463..6197
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013736.5"
                     /locus_tag="IE257_RS06840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14100"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_189965675.1"
                     /transl_table=11
                     /translation="MNTRERQLTEAFVALSDTLADEVDALVLLGRLTRHSVALTRIDAA
                     GVMLVNSRGHLRPAIATEHTLELTEMWQAQIRQGPCIDAFNQGIPVHADDLEADRDRWP
                     DFVPLALTAGYRSAHAVPLIAQCQTIGALNLLVGRPTPLDEAETHLLRALADVATTALM
                     TWKKDGLRSEDIVTSTQAVLSGKAVFDTATGMLAATADITPAQAARHLSAFADRHHQRP
                     TEIAADIVQRRITPQAVLGELS"
     misc_feature    complement(6483..6503)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.31"
                     /tool="antismash"
     misc_feature    complement(6515..6529)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(7270..7284)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.63"
                     /tool="antismash"
     gene            7590..9134
                     /locus_tag="IE257_RS06845"
                     /old_locus_tag="GCM10010343_14120"
     CDS             7590..9134
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019236.5"
                     /locus_tag="IE257_RS06845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14120"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_189965677.1"
                     /transl_table=11
                     /translation="MGAGTAHAAARTYFVSPSGKDSNSGTSTRAPFRTLQKAADSVEPG
                     DTVSIMNGTYSEPSAGSNVVTIKRSGLSGAPITFTAHPGHHPVIHPMQAWNGISIHGAS
                     YISIKNLEVKGNNAALTLAGAERESKKGDPTYNTNCISVEQDRSTGALSHHVEVTGNEV
                     HGCADGGISAIDSDHVTISGNHVFGTSWYAVDATSGISVLTPRDVGGGDAGTYKIRVTG
                     NRVHDNETKIKWEKCGCYSDGNGIIIDTLKGDADHPAYSGRVLVANNLSYDNGGSGIHS
                     YKSQHVDIVHNTAYANGRSTRMESYANIFAHDSTDVRLLNNIAYGRPGQATNSKSRNVD
                     VTYDYNVYFGGKAPEVQGPNDVIADPKLTKAGTGADADFRLSEGSPAAGSGTPFAAVTT
                     DFTGARRAGGAPDRGAYGLGAKSSGVPGNASAASSPGRQGDAPAGSGRSAGSDPTASPG
                     VQTGDGSNGGSGLKPHSGSGPLAETGGSDPVLPLGIAAVVLALGGGLLFVARRKRS"
     gene            9277..9912
                     /locus_tag="IE257_RS06850"
                     /old_locus_tag="GCM10010343_14130"
     CDS             9277..9912
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037271.5"
                     /locus_tag="IE257_RS06850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14130"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_189965679.1"
                     /transl_table=11
                     /translation="MAAARHRIEAATLTGGSVPDPPRVAWRKQMRQRVLDAARDLTCEA
                     GWDQVSLLAVAARAEVSRPSVYKEFGNRAGLGRALVVRETQQFLAGVADALYPGVPDSH
                     DCLRAAILYVLEEAESQPLIRAVVTAARKGSDSLLPYLTARADPIFYAGQTLVQGWLAT
                     RYPEQHTASLQIAADVIVRMTISHLILPADEQHLTAERLATAALKLLQ"
     gene            10001..11434
                     /locus_tag="IE257_RS06855"
                     /old_locus_tag="GCM10010343_14140"
     CDS             10001..11434
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017634.5"
                     /locus_tag="IE257_RS06855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14140"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_189965681.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 6.1e-96, bitscore:
                     317.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEHFARTASAPYERDGPALHRAFPHRRPAPRSAVRTGSPACAFR
                     FPGRAGSHCFLHPSIRPGRNTERRAGRPALSWNADVTIVGAGAAGLSLAAHLAGPPSGS
                     GFRPSVLMVEAPPGPLRSPDRTWCFWEAGGGPYDHLLEGSWDRLRVYGPDGTVVDRSLG
                     ALRYKMLRSGRFEEAMSERLRTSGIAVRQLTVERVTDTGDEAVVWGRDVAGVVSGLRSG
                     LVFDSRLPPRLPAARTTLLQHFRGWFVRTSKPVFDPSAAVLMDFRLPQPARGLAFGYVL
                     PTSCHEALVEYTEFSPATLDEVAYQRALSRYCGSILELGEYVVGEQEQGVIPMSDGRLP
                     RRHARRVFPIGVAGGATRPSTGYTFAAIQRHSLYVARAVREGRSPARVPAPHALRARTM
                     DAVLLRALDTGRVDGARFFTQLFSSVPAERVLRFLDGATSLWEDVGVGMRTPVVPMLRS
                     LLDLPLVPRSASASWPVHR"
     gene            11444..12151
                     /locus_tag="IE257_RS06860"
                     /old_locus_tag="GCM10010343_14150"
     CDS             11444..12151
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849731.1"
                     /locus_tag="IE257_RS06860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14150"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_189965683.1"
                     /transl_table=11
                     /translation="MSLLRDDSLSEAFDHAAARYDWMVSASPGYHGHLRRSARRLGLPD
                     AGRGARVLDLGCGTGASTAALLSAAPLAHITGVDASAGMLARAAEKPWPPGVRLIEASA
                     DRLGAAGVEGPFDAVFAAYLFRNVTDTDRTLKSVRAVMAPGARIAVHEYALSGRRMDRM
                     LWTAVCRSVIIPLGRAAGDARLYEHLWHSVLGFDTAAEFAGRMREAGFSRVRVLPLPGW
                     QRGITHTFVGVAA"
     gene            12148..13689
                     /locus_tag="IE257_RS06865"
                     /old_locus_tag="GCM10010343_14160"
     CDS             12148..13689
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888661.1"
                     /locus_tag="IE257_RS06865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14160"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_372452949.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-07, bitscore:
                     27.1, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 3.8e-13, bitscore: 45.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGQPYPGRDRRAHRVEVQGGRARLERGERRVAVVGGGIAGLSAA
                     TVLAERGVQVTLYERDAQLGGRLAGWQTRLADGSQATMSRGFHAFFRQYYNLRALLCRT
                     DPGLHSLTGLADYPLRHRNGGQDSFARVPRTPPLNALGFIAQSPSFTWRDLGRMNARAA
                     LPLLDVAVPQVYEALDGTSATDFLAAIRFPDAAHHLAFEVFSRSFFADPAELSAAELVL
                     MIHIYFLGSSEGLLFDVPREPFPHSLWEPLARHLDGLGVEIRTGTAVGQVRPAGREGMT
                     VVAQAGGEGYDAVVLALDTGGLQSVTAASPDLVSAAWRTRIGALRTAPPFLVSRLWLSQ
                     PVAGERPGFLGTSGYDGLDNVSVLDRWEGEAHRWALASGGSVVELHAYAVDPALPRRMV
                     EEGLVNRLREVYPETVDAKIIDARHEWRADCPLFTVGGYQDRPTVRTADCRVVVAGDLV
                     RTGLPVALMERAATSGFLAANALLEGWGARGEALWTVPRKGRLAAGRALAGLGRR"
     gene            complement(13731..14723)
                     /locus_tag="IE257_RS06870"
                     /old_locus_tag="GCM10010343_14170"
     CDS             complement(13731..14723)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736172.1"
                     /locus_tag="IE257_RS06870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14170"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_189965687.1"
                     /transl_table=11
                     /translation="MSARPFHRLPISLRRGPLPWHRQQPTWRAASPRIIAAALKRAQTR
                     PAGNWYVLGASTSVPRDAGYGATIEGTEIVAWRDGAGTLIAGPGACPHLGAALADAPVR
                     CGTLVCPWHGLALNGAPFAGWQPFPAHDDGILAWVRLDDHGGEDPLEAPSIPPRPPSGS
                     SLAAVYTGTGLCEPQDIIANRLDPWHGAWFHPYSFADLTVLDDGATTDVMTVKVSFKLG
                     GRLVVPVTAEFTAPDPRTVVMRITDGEGVGSVVETHATPLGPARDGSPRTRVTEAVIAT
                     SHRTGFTAARTAAPLLRPLIRHAAGRLWKDDLAYAERRWQLRSTGRYPG"
     gene            complement(14720..15703)
                     /locus_tag="IE257_RS06875"
                     /old_locus_tag="GCM10010343_14180"
     CDS             complement(14720..15703)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849728.1"
                     /locus_tag="IE257_RS06875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14180"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_189965689.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.3e-115,
                     bitscore: 380.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2e-62,
                     bitscore: 206.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRELDAARITDPTQRAAFTQCRHLNARHGKTYFLATRLLPPSR
                     RPAVHALYGFARLADDIVDDLSAPTSTEHRAQQLQRLSQDVRTAMDGDPGRHPVVNAVA
                     HTAHRYHIPRHYFDDFLASMRADLTVTDYPTLEALRSYMHGSAAVIGLQMLPVLGHVTS
                     REEAAPHAAALGEAFQLTNFVRDVGEDLDRDRVYLPADLLAAHGVDRDLLQWSRRTDRR
                     DPRITRALQAATELTRGFYAKAAPGIEMLDPVSRPCVRTACVLYGEILDAVARDGYASV
                     HHRSSVPLLRRGAVAAAGLAAISKARLTAAPADRPDLAGQALEEPR"
     gene            complement(15700..17238)
                     /gene="crtI"
                     /locus_tag="IE257_RS06880"
                     /old_locus_tag="GCM10010343_14190"
     CDS             complement(15700..17238)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456520.1"
                     /locus_tag="IE257_RS06880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14190"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_189965692.1"
                     /sec_met_domain="DAO (E-value: 5.1e-15, bitscore: 51.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTITGRTDHVVVVGAGLAGLSAALHLLGSHRRVTIVERDLLPGG
                     RAGLIEADGYRFDSGPTVLTMPHLLEEAFAAAGQSISDRLTLHPLHPAYRASFADGTSL
                     HVHTGAEAMEAEIERFAGGREVAGYRRLRRWLHDIYQAQMDRFIDSNFDSPLSLLNPDL
                     ARLAALGGFGRLQPKISRFLTDERLQRVFSFQALYAGIPPARALAAYAVIAYMDTIAGV
                     YFPQGGMHAVPTAMSAAAAEAGASLQYGQTVTALERTGERITAVITDQQRIPCDAVVLT
                     PDLPAAYRLLGARPRRPLALRHSPSAVVLHAGTDRTWPELAHHTISFGAAWRQTFQELT
                     RTGHLMSDPSLLITRPTATDPSLAPSGRHIHYVLAPCPNTTIGPSVTSWKDLGSRYRDS
                     LLRELEQRGLTGFEDAIRTEALVTPADWTAQGHAAGTPFSVAHTFPQTGPFRPRNLPNG
                     TSNAVLAGCGTTPGVGVPTVLISGRLAAARITGLARPRPKNPSAPSTAPQGHSA"
     gene            complement(17238..18428)
                     /locus_tag="IE257_RS06885"
                     /old_locus_tag="GCM10010343_14200"
     CDS             complement(17238..18428)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120223.1"
                     /locus_tag="IE257_RS06885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14200"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189965694.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.1e-51, bitscore:
                     169.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEVSSARHPTLSDTSPARLAGALAATVDEDVVAAVHRELKSRCD
                     ELIAFGRTLDPVFATDIAERLAAYTLSGGSRIRPRFLWWALRACGGSDYETPAALRIAA
                     ALELIQSCALIHDDVMDHSSVRRGRPSFHTQLALQYPAPAREAVTESFAHSASILAGDL
                     ALSWADDLVATTDLEPAKRASVRHLWRAMRTEMVAGQYLDLHGQATSSRSATRAIRTVC
                     LKTARYTVERPLALGAVLAGADESTSRALGAAGRCAGIAFQLRDDLLGVFGDPMATGKP
                     SGDDIRSGKPTYLIALAHTRARATKDTSVTDLLDSCRGDAELSGKALAAVREALVSTGA
                     PERVERRIARLGRAAEHHLRAAHLSGPAAVHLTGLLRQIAVPPEQQATGTVDRGSL"
     gene            complement(<19032..19296)
                     /locus_tag="IE257_RS37975"
                     /pseudo=""
     CDS             complement(<19032..19296)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049865.1"
                     /locus_tag="IE257_RS37975"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRALTWHGKRDVRVDTVPDFTIRDRADGSVKITTTGLWPPRLGPE
                     PLRGSRCLSRRRRHPGPRAHGHRGGGGTGRHFSEAGGPRGDPL"
     gene            complement(19525..20847)
                     /locus_tag="IE257_RS06895"
                     /old_locus_tag="GCM10010343_14220"
     CDS             complement(19525..20847)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612927.1"
                     /locus_tag="IE257_RS06895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14220"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_189965696.1"
                     /transl_table=11
                     /translation="MSRGPERGASGADNDVDAVLQTALQRLALLAEATDALSSTLDGQE
                     ALRRLCRVLVPQLADWCAADLLDEHGRPYRAVVEHFDPSRPTGHLQGPLPSMTQTCTDP
                     LARVLRGAGPLLADPAAVLAARDASALQAAQVRLFSTLGVKSAVIAPLRARRHVLGALT
                     LARSGDQLALTADDLALIDDLAQRTALAVDNARLYASVQDTAEHLQRSLLPRLSDLTPL
                     SVAARYIPARSAAEVGGDWFDCFRLPDGSTALIIGDVTGHDLPAAVTMGQLRNMLRALA
                     CDRKDPPGDILRRLDIATDTLYGGQTATGVYSRLVAASEGMWTLDYANAGHPPPLLITH
                     DGDTRYLTGGHSILLGVDPHTARPSASELLAEGTTVLLYTDGLVERPREHLDTGLERLR
                     QHAAALAREDVPTFLDELLAGLAQDSSDDIAVLALRLPPAQ"
     gene            complement(21231..21686)
                     /locus_tag="IE257_RS06900"
                     /old_locus_tag="GCM10010343_14240"
     CDS             complement(21231..21686)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033224.1"
                     /locus_tag="IE257_RS06900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14240"
                     /product="DUF6098 family protein"
                     /protein_id="WP_189965698.1"
                     /transl_table=11
                     /translation="MSGSSHWSRMAVIGSLDELTGLLSSRRGLYVRWSRGPQFDLLPEA
                     SSRDELTGVELPGLSANPMDVEDWWGPRPLRTWAARRLYDYSHLPRVKDTWVRPWLLLG
                     TEAGRGPDNEPVVRDVEPLGWVNQKVIDEAEREIEQQQGVWGPLNRR"
     gene            complement(21720..22499)
                     /locus_tag="IE257_RS06905"
                     /old_locus_tag="GCM10010343_14250"
     CDS             complement(21720..22499)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="IE257_RS06905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14250"
                     /product="ATP-binding protein"
                     /protein_id="WP_229920170.1"
                     /transl_table=11
                     /translation="MTIARSALLMMARERPRELVSQVPVPGCDGATLARLPHRGPTEAL
                     AGHVGSVMGGLGTDEQPERPGPGPIGASFLLNEWERLADARRLAHSFFDEIQVLHGLVV
                     SARVVEVVELIVSELVTNARKYASGPIRLTLEVADGRVEVSVWDSNPTPPAILPPDPFR
                     SGQHGLNIVIASTVSLKVYPELAGKRITAVALVADAHPIHGLWRSRPPPRHALPAELRR
                     CRHMPLPASAFDNGGYVPHEYSSTSERAVRGRWPPGS"
     gene            22958..23338
                     /locus_tag="IE257_RS06915"
                     /old_locus_tag="GCM10010343_14270"
     CDS             22958..23338
                     /GO_function="GO:0003779 - actin binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012460.5"
                     /locus_tag="IE257_RS06915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14270"
                     /product="profilin"
                     /protein_id="WP_189965702.1"
                     /transl_table=11
                     /translation="MDGAATELRRALESSCLAQAEILRMDGSTRTSTGQFLTTVREGRR
                     LVQMFEAPADAISEGIMVGGRRYLAAEANRHLLHGKQADSGVIAVRRPPFVVVGLYESG
                     QPSADAILAVDRLAALLASGSP"
     gene            complement(23776..23979)
                     /locus_tag="IE257_RS06920"
                     /old_locus_tag="GCM10010343_14280"
     CDS             complement(23776..23979)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS06920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_14280"
                     /product="hypothetical protein"
                     /protein_id="WP_189965704.1"
                     /transl_table=11
                     /translation="MAHDLATDIIRKLEDAVAANALPEHTVELLRVSLEQARTAKAAGH
                     DQEAVTIAGQALQAAESASGGQ"
     gene            complement(23999..24419)
                     /locus_tag="IE257_RS39345"
                     /pseudo=""
     CDS             complement(23999..24419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008734702.1"
                     /locus_tag="IE257_RS39345"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLAEQTMAALSEHGVSGKTIRIADHDVRPGVKTDMGGRDAWPEIQ
                     APILGCDILTLSIGHPPAPPSALRERLDA"
     misc_feature    complement(25190..25205)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            25343..25759
                     /locus_tag="IE257_RS06930"
     CDS             25343..25759
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955605.1"
                     /locus_tag="IE257_RS06930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CBS domain-containing protein"
                     /protein_id="WP_189966221.1"
                     /transl_table=11
                     /translation="MTKARDIMTADATCIGANETVLEAAKKMARLKVGSLPICGTDEKL
                     KGVLTDRDIVVKVLAADRDPGQVKAGDLAQGEAVTIGADDDAAEILRTMGAHQVRRLPV
                     IDGHTLVGIVALADVARALPDTKVGDLLEAISQD"
     gene            complement(26177..26839)
                     /locus_tag="IE257_RS06935"
                     /old_locus_tag="GCM10010343_14310"
     CDS             complement(26177..26839)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146337.1"
                     /locus_tag="IE257_RS06935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14310"
                     /product="phosphoribosyltransferase"
                     /protein_id="WP_189965706.1"
                     /transl_table=11
                     /translation="MRFHDRRHAGQELAARLLEWAAAGDLNDTLVLALPRGGVPVAAPV
                     ALALKAPVDVLVARKIGLPGRPEVGIGAIAGDDPPLFDEQVLEMLGLSEDRLGADVARE
                     RLELHRREAIYRDGRPAPSVTGRTVILVDDGLATGVTARAALHHLRRQDPGRLILAVPV
                     GSAGTADLMREEADEIICLHEPTDFHAVGQWYDDFDQVSDDAVIATLRNLHARPSPS"
     gene            complement(26902..27327)
                     /locus_tag="IE257_RS37980"
                     /old_locus_tag="GCM10010343_14320"
     CDS             complement(26902..27327)
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016994.5"
                     /locus_tag="IE257_RS37980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_14320"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_209468330.1"
                     /transl_table=11
                     /translation="MLALLTRLRHHSEQAAADTLDRLVEHRGPGAKAVVWEHNTHIGDA
                     RATDMAAAGMVNVGQLVRERHAAQGVVLVRFGSHHGTVTASDHRLPAGEREVGQLRQHR
                     PRRPVRRLPFIGTTGALTPLHAAAPDTAEEETWPTGM"
     gene            complement(27351..27930)
                     /locus_tag="IE257_RS39350"
                     /pseudo=""
     CDS             complement(27351..27930)
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016994.5"
                     /locus_tag="IE257_RS39350"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="erythromycin esterase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAITLQGRDDQRAGIRESALPLTGPGSLDPLMERIGDARYVLLGE
                     ASHGTAEFYRWRAALTRRLIGERGFSLVAVEGDWPDCQAVHCSVTAAAGAPEDPADVLR
                     GFSRWPTWMWANTDVLDFTRWLRAQHRAATRTAGGVLRPGRVLALGVPARGLRLSRLTR
                     PGRSRARPGGVPVLRAVRRGPAALRSATRL"
ORIGIN
        1 cagcacctcg taaaggtgca ggtccgaacc gcacagcccg gttgtcgtca ccttgatcac
       61 agcatccgtg ggatcgacga tctgcggatc cggaacagtc tccaccgtca cgttgcggcg
      121 gccctgccaa gtcacggcct tcatcacgcc tcctcatatc tgggtccgca atccggacct
      181 ttccgtctac cccgtccggg ttctcgcacg caccgggagc ggcctccgga tcacatccga
      241 ggcccgctga tctgcaagaa cgcctaagtg cgatccagat ggacgtggat ggtcttgccg
      301 ccttgccctg cgaggtgtcg cacgtcgacc tctttgccga gtcggttgac gaggtgccag
      361 ccccatccgc cttccccctg ctgaccgggg tcccgtagcc ggggttcggc actgctggtg
      421 tcgctgacgt cgacgtccag accgccgtcg ggtgtcctgt gcatgtccag cacgcagcca
      481 ccggacgtgt gacggacggc gttggtgacc agctcgctga tcaccagcag ggccgtatcg
      541 cgtgcgacgg ccgtgaacgc gcggtcgccc gcctcggacg gttccaggag gccgcgggct
      601 gcgctcctgg cagcccccgc ggcacccgga ccgttcagct ccaggtgcag gatcgggagg
      661 aggggcatgg atcggctccg aaagccacga cgagtccagg ggcgtacggg gtgtaacgcc
      721 ctccgttgtg cccctgcccc ctgcggcccg gcccagtcac ccccgcaatc gaatacgcgc
      781 cggtcgcttt cgcagcgggg aaggacgacg atggagcagg ggccggcgga gaatcgaggc
      841 gtgcaatgac tcgtgacgct gcggaaacgg cgcaacagtg agcgcggaaa agaccgtccc
      901 ggcggtgccg caatgcctgg gggcggttct ggcgtgggtg ctcgagcgct cccacggtgc
      961 ctccgcactg gagctgcccg gtgtgatcgg tgaggccgcc cgccgactcg ggatctcgcg
     1021 gacccgtctt tacctggccg acctgcaaca gcggcgcttg ctcccgctgc cccggcccga
     1081 cctcacggcg gaggaacgca aaggtctcgg cgtcgagggc tccctcgccg gtctggccta
     1141 ccgcacccag gaagtgcagt cgacgcgcgg cggggacacg acctggttcc ccatggtcga
     1201 cggcatcgag cggatcgggg tcatgcagac cctcacctcc ggccccgact ccgggctgct
     1261 ggaggccagc cgtgcgctgg cgagcctggc caccctcttg gtggtatcaa aatccaccca
     1321 ccacgacccg ctcgtccagg ggcagcgagt acggcccatg accctccagg ccgaactgct
     1381 gtgggcgttc ctgccgcccc ggaccatcgg caccgccctg gccacttcct ccgccgtgct
     1441 ggagcccgcc tacgacatcg ggggcgacgc cttcgaccac tgcttcatcg acggggtcct
     1501 tcacctgacg ctggtcgacg ctatgggtca cgacctcgct tccgggggcg ccagcggcgc
     1561 cgctctggcc gcgtgccgct ccacccgccg ctcgagcggc gacctccccg acatcgtctc
     1621 cgccatcgac cgcacgctgg cccagtggat cccggaccgg ctcatgaccg ccgtcatcgc
     1681 cgaactcgac accgctcaag gagacttcac ctggatcaat tgcggccacc cgccgccgct
     1741 cctcatccgc gacggccacg tgctgcagaa cgccctcgaa cgcccgcccc atctccccct
     1801 cggcttcggc ttccacaccc cggttccacc ggcacaggaa cacgtgcggc tccagcccgg
     1861 agaccgcgtt ctgatgtaca gcgacggcat caccgaagcg cgctcccccg agggcgacct
     1921 cttcggcgag gaacgcctcg ccgacaccgt catccgctcc accgcctcgg gcgacaacgc
     1981 ccccgaagca ctgcgccgcc tcgtccagaa ccttctcagc caccaccagc accacctgcg
     2041 cgacgacgcg acgatcctgc tcatcgaatg gcatcccttc ccccggacgc actgaccggg
     2101 ccgggggtgc tccggccgga agcgcgtcgc ccggtcgggc cgtccgtgtt agatgcgcat
     2161 gaggcagggc aggcgcaagg agcgatcctc tccgaggaag gcgcgcaaac cgaccgcgac
     2221 ggcgtcgggg cccaggcggc cgctcgtacg gcatgggcgg gcccggcccg gggcgaaggg
     2281 ccccctccgc agccgtcgga agggagtttc gtcatgtccg ggcggaggct ctcccacgag
     2341 gagaagatgg aactcgccgg catcgagagc gctctgtgcg acgagccgtc attccgcgtg
     2401 ctctcttccg agtacggcct cgtccccgct cacgggaaac gacggcgggc cgggtcctgg
     2461 agccttcctg ccgcattgtg gtgcgccgtg ttcctctcct tggcgctgct cgtgctggcc
     2521 actgccacgt cggcgccgcc cctgatcgcg gcgttcgccg tcagttacgc catgacgtcg
     2581 ggtctcctgg tggccctggt acgccagtgg tgcgccaggc atcccgacgg cccggagaac
     2641 tgacgccgcc ccgcggctgt cactccgttg cccggcccag ggtgaacagg gctccctgcg
     2701 gatcccgcag cgcgacctgc gagcgtcggt cggcatcggc cggaccaggc acctgtgtcg
     2761 ccccctgtgc gacggcgcgc tcccgtgcga cgtccaggtc ggggaccttg aagtggacca
     2821 gccaccgggg acggtcgtaa gactgctcgg cacccgcctc gacaggcccg ctgttcagcc
     2881 tggcgaccgc tgcaccggca ctgcgcagca ccacccgctc atcctcgtag gaggccgcgc
     2941 agtacccggg aacgtcctcg ccccgcctgt tacacagcag gactccatga acaccgatgc
     3001 gaaggagcgg acggatggaa caaccggtac agcagccacg gacgtccgcg gcgcctgaca
     3061 ggtgaacgcg ccgttcccat ggcctcgatc gcccgatccg gcttcgtcgc gggctcccgg
     3121 ttgacggtac ggcctcgcgt ccgtgcccct cgtccaccgt gcccgggtcg gggcggcctg
     3181 cctgaccgga ctcgggtacg tgtacggcgc gccgtcggac gccgctgtcg gatgaaccgt
     3241 gctcaggtcc ggcgctcggg tccagccggg attcagtggc cgagagcgcg cttgagttcg
     3301 gccttgtcca ccttcgactt ctacggctca gcccgccgcg ccgtcgacgc gcgcaggcgg
     3361 acctgctcct ccaggcgtgc gaggagggcc tcgtgcaccg tcgaccggcc catgagcacg
     3421 cacaggtgta ggcagcgtcc atggcgcgga gcgccgcggg gtccccgggc gcgactccga
     3481 ggcgggcccg gcggccccgc aaccgggtca gaacctcctc gacccgggtc ctggccggca
     3541 ggatcccgac gagcggtccc gccggccgcc cggacgtacg agccgcctcc atcggttacc
     3601 ggccggagac acgtgggatc ccttccaggg cggggcgggg cgggagtcgt ccgcggcgtg
     3661 acgacgcgct tacggaagga ttcccgcggg gcgcgcagtg gtacctgcgg cacgcccgtg
     3721 cccgtggcgc gtgcgggctc cggaatttcc gtggggcggc cacggttcgc ccggcccgag
     3781 ccatgggatg gtgggaggga tggaccagcc tggttccgtc gtatcgaggc ttcggcgccc
     3841 cagcctgccg tacgggcgcc ccctcgcggc cttcacgcgc cggacatgtg cacggcgcca
     3901 gccgtgcacc cggacgaggc ccttgcgggt ctgctgttca aggctgccgc cccgtgggcc
     3961 gtctcttccg gatcttgccg ggcccgcgac gcccggcacc gcacccggcc gcgttgtcgg
     4021 ggcgcccgag tacgcccact acaagggcgc ctctccgcct tgccggacac ggcaccggac
     4081 gccgcgggct cggccgacaa gatccgaaag agacggccca ggtggggaag ccccgtgacc
     4141 tcctgtctta cccgaatcca attcctgggc gcctacgccg tactgacccc gtgtcccggg
     4201 ccccgcaccg gccgggtcgc ggaatgccgg agccgaatca ctccggctct tgctctgctc
     4261 cggcccggcg tcacgtgtct cgtcctggat gtcgggtacc tctcggccgc cgatgccacc
     4321 gatgtcctgc cggtcgtgcg ggcctgggcc actcggcgct cggtttccct ggtacggatc
     4381 gggcgcgatg atgccccggg gcatccgccc gtccgcctcg tccacatccc gcgcaccgcg
     4441 gaggaacgct tgctccggcc cccgctcgcg gcgcgggtga tcgtgcaacg ggctacggga
     4501 atccgcctcg cgcactgggc ggacccccgt gccgcagcag ctgaccgccc cggcagcggt
     4561 gtaggcgaca gtcacccggt caatggtgca ggtgctgggc ccgatgaagg aagatggggt
     4621 aacgggctgc cactggaggt gaagcgccgt ggatcctgtc caccccgacg acctgccttc
     4681 cgggggcggc ggtccgctcc cacaggacgg ggaggagggc aggctgcaca gcgtgttcag
     4741 cggtgcggtc gacggcgttg ccagccacga cgtgcccgct gccctgtgcc gggcctgcgt
     4801 ggacctgatg gacgtcaccg gagcctcggt gtcgctgtcc ggcgaggacc ccgacatccg
     4861 caccctgtgg tggtcgagcg acgaagtggc cggccgcctc gccgaagccc agtacaccct
     4921 gggcgacgga ccctgcgtca ccgcgctcac ccacctcgcc cctgtcctgg ccgccgacct
     4981 cacccgcggg ccggatgccg cccgctggcc cgtcttctcc cagcaggccg tcgaactggg
     5041 cgtgcgggcg gtgttctcgc tgccgctgaa ccacagcgcc gtcgcgatcg gcaccctcga
     5101 cctctaccgc gaccgcaccg gccccctcac cgagagcgac cgctccttcg cgttccccgc
     5161 cgccgacgcg atcacgacgg cccttctcgc cctccaggcg caggattccg gagacggcct
     5221 cggagcgtcc tggctggacg aggcggagac ggaccacgaa gaggtccacc aggccaccgg
     5281 aatgatcatg gtgcacctgg gagtcgaccc ccaccacgca ctggcccgcc tgagggccta
     5341 cgccttctcc cacggacaga ccgtgacgga ggcggctttc gacgtcatcg ccggaagaat
     5401 caggttccgt gactagcccc gcccccaccc gcgggcctga ggagggaagc agtgaaaccg
     5461 gcatgaacac ccgcgagcga cagctcaccg aagcgttcgt agcgctcagt gacaccctcg
     5521 ccgacgaagt ggacgcactc gtcctcctcg gccggctcac ccggcacagc gtcgccctga
     5581 cccgcatcga cgccgcgggc gtcatgctcg tcaattcccg cggacacctg cgccccgcca
     5641 ttgccaccga gcacacgctg gaactcaccg agatgtggca ggcccagatc cggcagggtc
     5701 cctgcatcga cgccttcaac cagggcatcc ccgtgcacgc cgacgacctc gaagccgacc
     5761 gggaccggtg gcccgatttc gttcccctcg cccttaccgc cggctatcgg agcgcccacg
     5821 cggtgcccct gatcgcccag tgccagacca tcggcgccct caacctcctg gtcgggcggc
     5881 ccacccccct cgacgaggcc gagacacacc tgctgcgcgc cctcgccgat gtcgccacca
     5941 ccgcgctgat gacgtggaag aaggacggcc tccgatccga ggacatcgtc acctccaccc
     6001 aggcagttct gtccgggaag gccgtcttcg acaccgccac cgggatgctc gccgcgaccg
     6061 ccgacatcac cccggcccag gcggcccggc acctcagcgc cttcgccgac cgtcaccacc
     6121 agcgccccac cgagatcgcc gccgacatcg tccaacgccg catcacgccc caggccgtgc
     6181 tgggcgagct gtcgtgatgc ccaccgacgc gagggggcgg tcggtccata acgagtcacc
     6241 ctcacgcccc agtcggcgaa gtcctcagat gtacagggac acgccgacgc acaggggggc
     6301 ccgtccgtgt cacctgtgac cgttcacgcc ggccgcgatg agggagacac cgatgccccg
     6361 cagccaaacg tccttgacca gggcgattcc ctgctgtgtg ggacgcaggc tgccttcttc
     6421 ccgtatcgga agccgggcgg cggcccagtc gtataggcgt ggccctttgg cgccgtcgcc
     6481 gcaggagagc cgctgccatg cttcctgcgg ggcctggccg ataagatcgg tcgatgcgcg
     6541 gagccgtcgg cggcgcgatc ggccggggcg aagcccgtca cgtcggttcg gaagtagaca
     6601 tcatgcggag gatctgctcc cgtcccccac gatcggcgcg tactgcgtcc ccgaatagcc
     6661 tctgctccgg gaccgggtag cgcggtggcc gtttgcgagg cgagacccag tacaccctga
     6721 cgtcatcgtc gaagcggtcg gtgcgcgccg gatgtcgttc agggtgatcg gcgacagctg
     6781 ggctttccag gcccttgctg ggtgccatga cgtccgcggc cacatgccag gggtcgtgct
     6841 ccagcagccc tgcgtacaaa acggccgggt ggtgggcctt gagccacgcg gactgcagtg
     6901 cgggcacggc ggcggccgcg gcgtgcacac ggagaagccg taggagccga accccttgat
     6961 gatctcccac acctcttgca ggaccgttgg ggagccgcgc ccatgaacca ccttctgcgc
     7021 tgaggccgtc gacacaatcg tcttcaacgc ccgccctgct cgccccgacc gtgctggggg
     7081 cctgggggcc gcgctcggcc tgatcccgcc ggcggccacc gtccagcccg gccgagtcgg
     7141 tgaacctgat ggcttccagc ccatcccgga ttccgagccg cgctgctgtg acccgtaagc
     7201 cgggcgcgct gcggtcctcc gcagcgtcag ccagacagac agacagacag acagagtgat
     7261 gaaatgacga actgtcagaa cgtttacaca tagtccaggg ttgcgttcaa ttttcgagtc
     7321 tggaactgtc actcgagtaa ctcacccccc tcacagcgga cttcggagcg ctacccctcc
     7381 gggcttcact gcccggcgcc ttgccccggc gcggcgatac ggacgaaatg cctcctttgc
     7441 gtgctctctg ctcgtggcta cggcccacgg agggcaccag ccgcttcgcc aggacaaact
     7501 gggagaccag gcaacagtga aacgcacgag caccctcgcc cctgaccgca gcactgctcg
     7561 cttcatccgc ccccctcggc ctcgccacca tgggagccgg tacagcacac gccgcggccc
     7621 gcacgtactt cgtcagcccc agcggcaagg acagcaactc gggcacgtcc acccgagctc
     7681 ccttccggac ccttcagaag gccgcggaca gcgtcgagcc gggcgacacc gtctcgatca
     7741 tgaacggcac gtactccgag ccttcggcgg ggtcgaacgt ggtgaccatc aagcgctccg
     7801 gcctctccgg agcccccatt acgttcaccg ctcaccccgg ccaccatccg gtgatccacc
     7861 cgatgcaggc gtggaacggc atcagcatcc acggcgcctc ctacatctcc atcaagaacc
     7921 tcgaggtcaa gggcaacaac gcagccctca ccctggccgg agcagaacgg gaatccaaga
     7981 agggcgaccc cacctacaac accaactgca tctccgtgga acaggaccgg tccacgggcg
     8041 cgctgtcgca ccacgtcgag gtgaccggca acgaggtgca cggctgcgcc gacggcggca
     8101 tatcggccat cgactccgac cacgtgacca tctccggcaa ccacgtgttc gggacctcct
     8161 ggtacgcggt ggacgcaacc agcggcatct ccgtcctgac cccgcgcgac gtgggtggcg
     8221 gcgacgccgg gacgtacaag atccgcgtca ccggcaatcg cgtccacgac aacgagacca
     8281 agatcaaatg ggagaagtgc ggctgctact ccgacggcaa cggcatcatc atcgacaccc
     8341 tcaagggcga cgccgatcac cccgcctaca gcggacgcgt cctggtcgcc aacaacctct
     8401 cgtacgacaa cggcggctcc ggcatccact cgtacaagag ccagcacgtc gacatcgtcc
     8461 acaacacggc ctacgcgaac gggcgcagca cccgcatgga gagctacgcg aacatcttcg
     8521 cgcatgacag taccgacgtg cggctgctca acaacattgc gtacggccgg ccggggcaag
     8581 cgacgaacag caagtcccgc aatgtggacg tcacctacga ctacaacgtc tacttcggcg
     8641 gtaaggcccc cgaggtccag ggcccgaacg atgtcatcgc cgatccgaag ctcaccaagg
     8701 cgggcaccgg cgcggacgcg gacttccggc tgagcgaggg atcccccgcc gccggctcgg
     8761 gtacgccgtt cgccgccgtc accaccgact tcaccggagc ccgccgggcc ggcggcgcgc
     8821 ccgaccgggg cgcctacggc ttgggcgcca agagcagcgg cgtcccggga aatgcctccg
     8881 ccgcctcctc tcccggccgg caaggggacg cccccgccgg gagcggccgg tccgccggaa
     8941 gtgaccccac cgcatcaccg ggcgtgcaaa ccggcgacgg cagcaatggc ggctccgggc
     9001 tgaagccgca cagcggaagc ggtccgctcg cagagacagg cggctccgac cctgtactcc
     9061 cgctgggtat cgcggcggtg gttctcgccc tcggcggcgg tctcctcttc gtggcgcggc
     9121 gcaagcgctc ctgatccctg cggatcactt ggggcgccat gacgtggtgc cggccccgcc
     9181 ccctctccaa gggtcggcac caccgcgcgc ccgccgggca cgcactcacg agcccggttc
     9241 gccgaacggg cctcggcccc tggcagactg gccactatgg cggcggcaag gcaccggatc
     9301 gaagcggcga cactcacagg tgggtcggta cccgaccccc cgcgcgttgc ctggcgcaaa
     9361 cagatgaggc agcgtgtatt ggatgccgct cgcgacctca cgtgcgaagc cggctgggac
     9421 caggtcagcc tcttggccgt cgctgcccgc gccgaagtgt cgcggccgtc ggtgtacaag
     9481 gagttcggca accgcgccgg cctgggccgt gcgctggtag tccgtgaaac ccagcagttt
     9541 ctggcgggtg tggccgatgc cctctatccc ggggtgcccg attcccatga ctgcctccgg
     9601 gcagccatcc tctacgtact tgaggaggcc gagagccagc ccctcatacg ggccgtcgtc
     9661 acagccgccc gaaagggctc cgacagcctc ctgccctacc tcaccgcccg agcggacccg
     9721 atcttctatg ccggtcaaac cctcgtccag ggctggctgg ccacgcgata cccggaacag
     9781 cacacagctt ctctgcaaat agcagcggac gtcatcgtcc gcatgaccat cagccatctc
     9841 atcctgccgg ccgacgaaca acatctcacc gcggaaagac tggcgactgc agccctgaaa
     9901 ctactgcagt aaggagcact cgcgggaagg tgacacccgc agcctccgca cggcgaccgg
     9961 cacccggttg cgccgccgct cacaccccac cgcccccaag atgggcgagc acttcgcccg
    10021 aacagcctct gctccgtacg agcgagacgg gccggctctc caccgggctt tcccgcaccg
    10081 ccggcctgca cctcgttcgg cagtccgcac cggctctccg gcgtgtgcct tccgcttccc
    10141 gggacgggcg gggtcacact gttttctgca tccgtccata cgcccgggtc ggaatacgga
    10201 acgtcgcgcc ggaaggcccg ccttgagctg gaacgctgat gtcaccatcg tcggagcagg
    10261 agcagcgggg ctgtccctgg cggctcacct ggccggtcct ccctccgggt cagggtttcg
    10321 gccgagcgtc ttgatggtgg aggcaccgcc ggggcccctg cgttcgccgg accggacctg
    10381 gtgcttctgg gaggcgggcg gggggccgta cgaccacctg ctcgaaggga gttgggaccg
    10441 gctgcgcgtg tacgggcctg acgggacggt tgtcgaccgg tcattggggg ctctgaggta
    10501 caagatgctc aggtcgggcc gcttcgagga ggccatgtcc gagcggctgc gcacatccgg
    10561 gattgcggtg cggcagctca cggtcgagcg ggtcacggac accggtgacg aagctgtggt
    10621 gtggggccgt gatgtggcag gggttgtatc gggccttcgg tcgggtctgg tcttcgactc
    10681 gcggctgccc cctcggctgc cggccgccag gaccacgctg ctgcagcatt ttcgaggctg
    10741 gttcgtccgg acttcgaagc cggtcttcga tccgagtgcg gccgtcctga tggatttccg
    10801 tcttccccag cctgcccgcg gcttggcttt cgggtacgtc cttcccacca gctgccacga
    10861 ggctctggtg gagtacacgg agttctcccc cgccaccttg gacgaagtcg cttaccagcg
    10921 cgccctgagt cgctactgcg gcagcatcct ggagttgggc gagtacgtgg tgggcgagca
    10981 ggaacagggc gtgattccca tgagcgacgg gcgcctgccc cgtcgccatg cgcgccgggt
    11041 cttccccatc ggtgtcgcgg gcggggcgac ccgcccgtca accgggtaca catttgccgc
    11101 gatccagcgg cacagtctgt acgtggcccg cgccgtccgg gaaggacgct ctccggcccg
    11161 cgtgccggcc ccgcacgcac tgcgggcgcg gacgatggac gccgtgctgc tgcgggccct
    11221 ggacaccggc cgggttgacg gcgcccgatt cttcacacag ctcttctcgt ccgtgccggc
    11281 ggaacgggtg ctgcggttcc tcgacggagc cacttctttg tgggaggacg tcggcgtggg
    11341 catgcgtacg cctgtggttc ccatgctgcg ctcgctgctg gatcttcccc tggttcctcg
    11401 gtccgcgtct gcctcttggc cggtgcatcg ctgaaaggct cccatgtccc tgctgcgcga
    11461 cgattccctg tccgaggcgt tcgaccacgc cgcggcccgc tatgactgga tggtttcggc
    11521 gagccccggc tatcacgggc acctgcgccg ctctgcccgg cggctgggtc tgccggacgc
    11581 cgggcgcggt gcccgtgtcc tggatctggg gtgcggcacc ggtgcatcga ccgctgcact
    11641 gttgtcggcg gcgccgctgg cccacattac gggtgtggac gcttctgcgg gcatgctcgc
    11701 aagggcggcg gagaagccgt ggcctcccgg tgtccgcttg atcgaggcct cggcggaccg
    11761 gctcggtgct gcgggcgtcg agggaccctt cgacgctgtc ttcgccgcct acctgtttcg
    11821 caacgtgacc gacaccgacc gaacactgaa gtcggtgcgc gccgtgatgg cacccggtgc
    11881 ccggatcgcc gtgcacgagt acgcactcag cggtaggcgc atggaccgga tgttgtggac
    11941 ggcggtgtgc cggtcggtga tcatcccgct gggcagggcg gctggggacg cgcggttgta
    12001 tgagcacttg tggcacagcg tgctggggtt cgacacggcg gctgagttcg cgggaaggat
    12061 gcgggaggca gggttttccc gggtgcgggt gctaccgctg ccggggtggc agagggggat
    12121 cacgcacaca ttcgtcgggg tcgcggcgtg agggggcaac cgtatccggg gcgggaccgg
    12181 cgggcccacc gggtcgaggt ccagggtggg cgggcgcgcc tggagcgggg tgagcggcgg
    12241 gtggccgtgg tgggcggggg gatcgccggg ctgtcggcgg ccaccgttct ggccgaacgc
    12301 ggggtgcagg tcaccttgta cgagcgggac gcgcagctcg gggggaggct ggccgggtgg
    12361 cagacgcggc tggccgacgg ttcacaggcc acgatgagtc gcggcttcca cgcgttcttc
    12421 cgccagtact acaacctgcg ggcgctgctg tgccggaccg atccgggcct gcacagcctg
    12481 accggactcg cggactaccc gctgcgccac cggaacggag ggcaggacag cttcgcgcgc
    12541 gtgccgcgta cgccgccgct gaacgctctc gggttcatcg cacagagtcc gtccttcacg
    12601 tggcgcgacc tgggacggat gaatgcgcgg gcagccctgc cgctcctgga cgttgcggtg
    12661 ccgcaggtgt acgaagcgct ggacgggacg agcgccaccg atttcctggc ggccatccgt
    12721 ttccccgacg ccgcgcatca tctggcattc gaggtgttct cgcggagctt tttcgccgac
    12781 ccggcggagc tgtcggcggc cgagctggtg ttgatgatcc acatctattt cctggggtcc
    12841 agtgaggggc tgctgttcga cgtgccgcgt gagccgttcc ctcactcgtt gtgggagcca
    12901 ctggcccgtc atctggacgg gctcggtgtg gagatccgca caggcacggc ggtaggccag
    12961 gtccgaccgg ccggccggga ggggatgacg gtcgtcgcgc aggcgggcgg cgaggggtac
    13021 gacgcggtgg tgctggctct ggacaccggt gggctgcagt cggtaaccgc tgcctcgccc
    13081 gatctggtga gcgctgcgtg gcggacgcgg atcggcgctc ttcggacggc cccgccgttt
    13141 ctggtgtcgc ggctgtggct gtcgcagccg gtggccgggg agcggcccgg gttcctgggc
    13201 accagcggct acgacggcct ggacaacgtg agcgtcctgg accggtggga gggcgaagcg
    13261 caccgttggg cgctggcgag cggcggctcg gtggtggaac tgcacgccta cgccgtggat
    13321 cccgccctgc cacgccggat ggttgaggag ggactggtga accggttgag agaggtctat
    13381 ccggaaaccg ttgacgcaaa gatcatcgac gcccgccacg agtggcgcgc ggactgcccc
    13441 ttgttcaccg tgggcggcta ccaggaccgg cctacggtgc gtaccgctga ttgccgggtg
    13501 gtggtggccg gggatctggt gcgtacgggg ttgccggtcg cgctgatgga gcgcgctgcg
    13561 accagtggtt tcctcgccgc gaacgccctg cttgaagggt ggggcgctcg cggcgaggcg
    13621 ttgtggacgg tcccccgcaa gggccgtctg gctgccggcc gggcactggc gggcctgggg
    13681 cgccggtgat ccggggcgcg gatgcccacg gcctcgtaag ccttgcgggg tcaaccgggg
    13741 tagcggccag tgctgcgcag ttgccagcgg cgttcggcgt aggcgaggtc gtccttccac
    13801 agacgtccgg cggcgtgccg gatcagaggg cgtaggagtg gcgcggcggt gcgggcggcg
    13861 gtgaagccgg tccggtggga tgtggcgatg acggcttcgg tgacgcgggt gcgggggctg
    13921 ccgtcgcgcg cgggccccaa tggtgtggcg tgggtttcga caacggatcc gaccccctcg
    13981 ccgtcggtga tgcgcatgac cacggtgcgg gggtccgggg cggtgaactc cgccgtcacg
    14041 ggtacgacga gacggccacc cagtttgaag gagaccttca cggtcatgac gtcggtggtg
    14101 gccccgtcgt cgaggacggt gaggtcggcg aaggagtagg ggtgaaacca ggcgccgtgc
    14161 cagggatcga gtcggttggc gatgatgtcc tggggctcgc acaaccccgt gccggtgtag
    14221 acggcggcca gcgaagatcc ggagggcggc cggggcggga tggagggtgc ctccagcggg
    14281 tcctcgccgc cgtggtcgtc gagccggacc caggccagaa tgccgtcgtc atgggccggg
    14341 aagggctgcc agccggcgaa cggggcaccg ttgagggcca gtccgtgcca gggacagaca
    14401 agggttccgc agcggaccgg agcgtcggca agcgcggcac ccaggtgcgg acaggccccg
    14461 ggcccggcga tcagggtccc ggcgccgtcc cgccacgcca cgatttcggt gccttcaatg
    14521 gtcgcgccgt agccggcatc acggggtacg gacgtgctgg cgcccaggac gtaccagttg
    14581 cctgccgggc gcgtctgcgc ccgtttgagg gcggccgcga tgatccgggg agaggcggcg
    14641 cgccacgtcg gctgctgccg atgccagggc agggggcccc ggcgcaggct gatcggcaga
    14701 cggtgaaagg gacgggcgct catcgaggct cctccaacgc ttggccggcg aggtcgggcc
    14761 ggtccgcagg ggcggcggtc agacgggctt tgctgatcgc ggcgagcccc gcggcggcaa
    14821 cggcccctcg gcggagcagg gggacggagg atcggtgatg gacgctggcg tagccgtcac
    14881 gcgcgacggc gtcgaggatc tccccgtaca gcacgcaggc ggtacgcacg catggccggg
    14941 agacggggtc gagcatctcg atgccgggcg ccgccttggc gtagaagccc ctggtgagct
    15001 cggtagcggc ctggagggcg cgggtgatgc gggggtcgcg ccggtcggtg cgcctgctcc
    15061 attgcagcag gtcgcggtcc acgccatggg cggcgaggag gtcggcgggc aggtagacgc
    15121 ggtcgcggtc gaggtcttca ccgacgtcgc ggacgaagtt ggtcagttgg aacgcctcgc
    15181 cgagagcggc tgcgtgcggg gcggcttctt cgcgggaggt cacgtggccg aggaccggaa
    15241 gcatctggag gccgatgacg gcggcggagc cgtgcatgta gctccgcagg gcctcaaggg
    15301 tggggtagtc ggtgacggtg aggtcggcgc gcatcgaggc gaggaagtca tcgaagtagt
    15361 ggcgggggat gtggtagcgg tgcgctgtgt gggcgaccgc gttgacgact ggatgacggc
    15421 cagggtcacc gtccatggcc gtacgtacgt cttgcgaaag cctctggagc tgctgcgccc
    15481 ggtgttcggt tgaggtgggg gcactcaggt cgtcgacgat gtcgtccgcg aggcgtgcga
    15541 agccgtagag ggcatggacg gcggggcggc gggagggtgg caggagccgg gtggctagga
    15601 agtatgtctt cccgtggcgg gcgttgaggt ggcggcactg ggtgaaggct gcgcgttggg
    15661 tggggtcggt gatgcgggcg gcatcgagtt cgcgtcgtgt catgcgctgt gtccttgagg
    15721 cgccgtggac ggggcggatg ggtttttggg gcgaggccgg gcgaggccgg tgatgcgggc
    15781 tgcggcgagg cggccggaga tcaggacggt gggcacgccg acgccggggg tggtgccgca
    15841 gccggcgagg acggcgttgc tggtgccgtt ggggaggttg cggggccgga aggggccagt
    15901 ctgcggaaac gtgtgggcga cggagaaggg tgttccggcg gcgtggccct gagctgtcca
    15961 gtcggcgggg gtaacgaggg cctcggttct gatggcgtcc tcgaaaccgg tcaggccgcg
    16021 ctgctccagc tcgcgcagca ggctgtcgcg atagcgggac cccaggtcct tccaggaggt
    16081 gaccgagggg ccgatggtgg tgttggggca gggtgcgagc acgtagtgga tgtgtcgccc
    16141 ggacggagcc aggctcgggt cggtcgcagt gggtcgggta atgagaaggg agggatcgct
    16201 catcaggtgg ccggtgcggg tgagttcctg gaaggtttgc ctccaggcgg cgccgaagga
    16261 gatcgtgtgg tgggccagtt cgggccaggt ccggtccgtc ccggcgtgca ggaccaccgc
    16321 cgacggcgaa tggcgcaggg cgagggggcg gcgcgggcgg gcgccgagca gccggtaggc
    16381 ggcgggaagg tctggggtga ggaccacggc gtcgcagggg atgcgctgct ggtcggtgat
    16441 gacggcggtg atccgctcgc cggtgcgttc cagggcagtg acggtctgac cgtactggag
    16501 gcttgcgccg gcctccgcgg cagccgcaga catagcggtg ggtacggcgt gcatgccgcc
    16561 ctgggggaag tacacgccgg cgatggtgtc catgtaggcg atgacggcgt aagcggccag
    16621 ggcgcgggcg ggtgggatac cggcgtagag ggcttggaag gagaagacgc gctggagtcg
    16681 ctcgtcggtg aggaaacggc tgatcttcgg ctgaaggcgg ccgaagccgc ccagggcagc
    16741 gagccgggcc aggtcggggt tcagcaggga cagtggcgag tcgaagttgc tgtcgatgaa
    16801 tcggtccatc tgcgcctggt agatgtcgtg cagccaccgg cgcagacggc ggtatcctgc
    16861 gacctcgcgc cctccggcga agcgttcgat ctcggcttcc atcgcctcgg ccccggtatg
    16921 gacgtgcagg ctggtgccgt ccgcgaagct ggcgcggtag gcggggtgca acgggtgcag
    16981 ggtcagccgg tcggagatgg actggcctgc ggcggcgaag gcttcttcga gcaggtgcgg
    17041 catggtgagc acggtcggac cgctgtcgaa acggtagcca tcggcttcga tgagcccggc
    17101 tcggccgccc gggagcaggt cacgttcgac gatggtcacg cgtcgatggg agccgaggag
    17161 atggagcgct gcggacagcc ccgcgagtcc ggcgccgacg acgacgacgt ggtcggtacg
    17221 cccggtgatc gtcttcatca aaggctcccg cggtcaactg tgccggtggc ctgctgctcg
    17281 ggcggtacgg caatctgacg cagcagcccg gtcaggtgca cagcggcggg cccgctcaga
    17341 tgtgctgcac gcaggtggtg ttcggcggca cggcccaggc gcgcaatgcg tcgttcgact
    17401 cgctccggag cgccggtgga gaccaacgcc tcacggacag cggccagcgc cttgccggag
    17461 agttcggcgt ccccccggca ggagtccaga aggtcagtga cggacgtgtc cttggttgcc
    17521 cgggcgcgtg tgtgggccag cgcgatcagg taggtgggct ttccggagcg gatgtcgtcc
    17581 ccggagggct tgccggtcgc catgggatcg ccgaacacgc cgagaaggtc atcccgtagt
    17641 tggaaggcga ttccagcgca ccggcccgcc gcacccaggg cacgggaggt gctctcgtcg
    17701 gctccggcca ggaccgcgcc gagggccagg ggccgttcca ccgtgtagcg ggcggtcttg
    17761 aggcaaacgg tgcggatggc ccgggtcgcg gagcgggatg aggtggcctg accgtgcaga
    17821 tcgaggtact ggcctgcgac catctcggtt ctcatggcac gccagagatg ccggacactg
    17881 gcgcgtttcg cgggttcgag gtcagtggtg gcgaccaggt cgtccgccca ggacagagcg
    17941 aggtcgcccg ccagaatgga ggcggagtga gcgaaggact cagtgacagc ctcgcgagcg
    18001 ggggccgggt attgcagagc gagctgtgtg tggaaggagg gccggccccg gcgcaccgag
    18061 gagtggtcca tgacgtcgtc gtggatcagg gcgcagctct gaatgagttc gagagctgcg
    18121 gcaatgcgca gggccgcagg tgtttcgtag tccgatccgc cacatgctcg cagggcccac
    18181 caaaggaagc gcgggcggat ccgtgagccg ccgctgaggg tgtaggcagc cagccgttcg
    18241 gcaatgtccg tggcgaagac ggggtccagg gtacggccga acgcgatgag ctcgtcgcag
    18301 cggctcttca actctcggtg tacagctgcg acgacgtctt cgtcgactgt ggcggccagg
    18361 gcgccggcga gccttgcggg cgatgtatcg gagagggttg gatgtcgcgc agacgacact
    18421 tcttccattc ggtcctccgt gtcgtgaagt ggcgtatgcc gcctgtttcg cgtcgacagg
    18481 gcggacggat gcactcgccg gtgttcccgt ggctccgcgc cccatatgtc cccctccagg
    18541 cgtggggctc agacagacca cccggcccat ccacccaatg ggcgcatctg cggaacgggg
    18601 tacggcttcg gcgccgtcgc ggaacaaggc gtggtgctct cagggtccgg agaccagcga
    18661 cgttttgggg ctcgggtgag ccgcgctgga ggagccagat ggtgccgaag atgccaagga
    18721 agaactacac gaactccggc tgccagttct cggtcacgtc aaggggcgaa gtccctgaac
    18781 atcaggtact cgccgagcgt cagtggctgg agcccatcgg ggggcgagga cctcgttgaa
    18841 tccgggcacc cggtcccacg ttcgggcgac gcgatgagat ggcgtcccgc cacatggcgg
    18901 ccggcgacaa cgaagagcgc gaagataaca agacggatgg gactctcgag aaggctgctg
    18961 ccggcgtacg gctcgtggag gctctggttg ctcgcgtgcc cggattccgc cgccccgcgc
    19021 cggcccggcg caaaggggat caccacgcgg tcccccggct tcggagaagt gacgtccggt
    19081 cccacctcct ccacgatgcc catgggctcg tggcccagga tgtcgcctgc gtcgagaaag
    19141 gcatcgagaa cctcgtagag gttcaggtcc gagccgcgga ggccagaggc cagtggtcgt
    19201 gatcttgacg gacccgtcgg cgcggtcgcg gatcgtgaag tcgggcacgg tgtcgacgcg
    19261 tacgtcccgc ttgccgtgcc atgtgagtgc ccgcaagcac ttcctccggc gaaccgggca
    19321 tggggggcac gaccatgccg gcctccaccc cgatccgcag gtagcgcagg atgtggggct
    19381 tgtgccgcag ccacagcggt tcgccctcag gtcacacgtg catcacacgt gcatggctgc
    19441 tccgctaccc cgttccacac cggacagcag cacagccctg tcgggtccgc atgatctgtt
    19501 cggggatcga tcactggtcg gggatcattg tgcgggcggc aggcgcaggg cgaggacggc
    19561 gatgtcgtcg ctgctgtcct gggccaggcc ggccaggagt tcgtcgagga aggtggggac
    19621 gtcctcacgg gcgagggcgg cagcatgctg gcggagccgt tccagaccgg tgtcgaggtg
    19681 ttcgcgaggg cgctcgacga ggccgtcggt gtacagcagg acggtggtgc cctcggcaag
    19741 gagctctgag gcgctgggac gggcggtgtg cgggtcgacg cccaggagga tgctgtggcc
    19801 gccggtcagg taacgagtgt cgccgtcgtg ggtgatcagc agagggggcg ggtggccggc
    19861 gttggcgtaa tccagtgtcc acattccttc gctggccgcc accaggcggg agtacacgcc
    19921 ggtggcggtc tggccgccgt agagggtgtc ggtggcgatg tccaggcggc gcaggatgtc
    19981 gcctggcggg tctttgcggt cgcaggccaa ggcgcggagc atgttgcgga gctggcccat
    20041 ggtcacggcg gccgggaggt catgtccggt gacatcgccg atgatcaggg ccgtggagcc
    20101 gtcgggaagg cggaagcagt cgaaccaatc cccgccgact tcggcggcgg agcgggccgg
    20161 gatgtaccgg gcggccacgc tcagcggggt caggtccgaa aggcggggca ggagggagcg
    20221 ctgcaggtgt tcggctgtgt cctggaccga ggcgtagagg cgggcgttat cgacggcgag
    20281 ggccgtgcgc tgtgccagat cgtcgatcag cgcgaggtcg tccgcggtca gggcgagctg
    20341 gtcgccgctg cgggccaggg tcagggcgcc caggacgtga cgtcgggccc gtagcggggc
    20401 gatcactgcg gacttgacgc cgagggtgct gaagaggcgg acctgtgcgg cctgcagcgc
    20461 ggacgcatct cgggcggcga gaactgctgc gggatcggcc aggagcgggc cggcgccgcg
    20521 cagcactctg gcaagggggt cggtgcaggt ctgcgtcatg gacggaagcg ggccctgcag
    20581 gtggccggtc ggccggctgg ggtcgaagtg ctccaccacg gctctgtacg gtcttccgtg
    20641 ctcgtcgagc agatcggcgg cgcaccagtc ggccagctgc ggcaccagca cccggcacag
    20701 ccgccgcaac gcttcctggc cgtcgagcgt gctcgagagt gcgtcggtgg cctcggcgag
    20761 cagcgccagt ctctgcaacg cagtctggag caccgcgtcc acatcgttgt cggccccgct
    20821 ggcgccgcgc tccggacccc tgctcatacc gctctttcta cccggcctct gccccgcgag
    20881 cgtggcgccg cccgcatacc tgagtgaccc cgaccccgaa cgcgggccca cagccccttc
    20941 caggtccgca atcacggcat gccacgatct ctggcctggg aaaggctgca ccgccgggcc
    21001 ctaccggcga tcttacggcg tcacgggtgg tcgggacgct gctcaggcgg ggtgggaccg
    21061 cccgtctgag aacggctttc ccggtcctcc cccgtcttcg tcgcgttctt cggctgggct
    21121 gccttgaggt gcctgctctc ctgcggggtc gcggcgccct taccactgcg ccgtgcctcc
    21181 ggctgctgtg catcacccac gatctcggtc ctctcaaagt gccgaagggg tcacctgcgg
    21241 ttgagcggcc cccatacgcc ttgctgctgc tcgatctccc tttccgcttc gtcgatcact
    21301 ttctgattca cccaccccag gggctccacg tcccgtacga cgggttcgtt gtcgggcccg
    21361 cgcccggcct cggtgccgag gagcagccag ggtctgaccc aggtgtcctt cactcgcggc
    21421 agatgcgagt agtcgtacag ccgtcgcgcg gcccacgtcc gcagcggccg cggtccccac
    21481 cagtcctcca cgtccatagg attcgccgac agaccaggca gctcgacacc ggtgagctcg
    21541 tccctgctcg acgcctcggg gaggagatcg aactgcgggc ctctcgacca gcgcacataa
    21601 agcccgcggc ggctggagag caaccctgtc agctcatcca acgacccgat gaccgccatc
    21661 cgtgaccagt gcgatgagcc gctcatgaga tcgccttccg cgtggtcggg tcacggcccc
    21721 tacgatccgg gtggccatcg gccccgcacg gctcgctcgg aagtggagct gtactcatgg
    21781 ggcacgtacc cgccgttgtc gaacgcactc gcggggagcg gcatgtggcg gcatctgcgt
    21841 agttcggctg gcagggcatg gcggggcggc ggccggctgc gccataggcc gtggatgggg
    21901 tgggcatcgg cgaccagggc taccgcggtg atccgtttcc cggcgagctc cgggtagacc
    21961 ttgaggctta cggtcgaggc gatgacaatg ttcaggccgt gctggccgct ccggaagggg
    22021 tccgggggca ggatggcagg cggggtgggg ttgctgtccc agacgctcac ttcgacgcgg
    22081 ccgtcggcca cttcaagggt cagccgaatc ggaccggatg cgtacttgcg ggcattggtg
    22141 accagctcgc tgacgatcaa ctccaccacc tcgaccacac gagcagaaac caccagaccg
    22201 tggagaactt gtatctcgtc aaaaaatgag tgagccaggc ggcgggcgtc tgcgagcctc
    22261 tcccactcat tgagcaggaa ggaagcgccg atcggaccgg ggccgggccg ttcgggctgc
    22321 tcgtccgtac ccagaccgcc cataacgctg cctacgtgcc cggcaagggc ctcggtcgga
    22381 ccgcgatggg gcagtcgtgc cagtgtcgcc ccatcgcagc cgggcaccgg gacctggctg
    22441 accagctcgc gaggccgttc cctggccatc atcagcaacg ccgaccgcgc gatggtcatg
    22501 ctcctcgatg gcgagaccga tgccggcgag cacgcactca gccccggcgc cggcagctca
    22561 agcagcggct tcgtcctggc gaacggacaa cacgacgagt atcccgagga ggccaccgtc
    22621 ccactcacag aagcgatggg gatcgtaagc cacatcctca caacaggtgc cccaccctca
    22681 gacgctcctt gggcgatcga ccgttgacga ggccaccacc cggggaatta cgtggagtta
    22741 gcctggaggt atgaggagtg accgtccgca accggctcac cgagctcggc gaacggctcg
    22801 acgcggagaa gaagaacgct ccgcgcgatc cggtggccgc gcccagcccg tccagcaagt
    22861 agagaccgga tcgcgctcgc ctctcacgca ttcgccgtcc tcagccggga aaacgcatag
    22921 tgcgaaggtg ccatgaggat gaggatggag cgccgagatg gacggtgcag cgacagaact
    22981 gcgacgggcc ctcgagtcga gctgtctcgc gcaggccgag atcctgcgga tggacggctc
    23041 cacacgtacc tcgacgggcc agttcctcac cacggtgcga gagggcaggc gactggtgca
    23101 aatgttcgag gcgccggctg acgcgatcag cgagggaatc atggtcgggg gccggaggta
    23161 cctggccgcg gaggcgaaca ggcacctttt gcacggcaag caggcggact ccggggtgat
    23221 cgccgtccga cggcccccgt tcgtcgtcgt aggcctctac gaatcgggcc agccgtcggc
    23281 cgacgccatc ctcgccgtgg atcggctcgc cgcactgctc gcttccggtt ccccgtaacc
    23341 gcgcccccga cagcgcagaa accaggcgaa gcgggaggaa aacaaactgc ctactgcccg
    23401 cgagccgact gcatcgcgcc ggcgagacca tcctggaaac agcagaaaca tgaaggagcc
    23461 ggaggtcggc gcactgctca tccgacaaca ggagcaagag catgccgacc cggagatcgt
    23521 ggcgaaggtg ccggcgaagg gcaaggcccc cgcccagtga aaggacggcg atcgtgcagg
    23581 acgaggcggt gaccatcggt accgacgacg agcaagaggc cgttcaccaa gcccgcgccc
    23641 gcactgccgg gcgcagacaa cgatggcgaa ccggtccggc gcccgcacct ccgcgtgcac
    23701 gcaggaaagg cgacccgtcg acctgatccc ttcgacggcc ccgcgttacc ccaggcttgc
    23761 gagccacgga ccgtactact ggcccccaga agcactctcg gccgcctgga gagcctgacc
    23821 ggcgatcgtg acggcctcct ggtcgtggcc cgccgctttc gccgttcggg cctgttcgag
    23881 ggagacgcgc agcagttcga cggtgtgctc cggcagagcg ttcgccgcca cggcgtcttc
    23941 cagtttgcga atgatgtcgg tggccaggtc gtgggccatg gggccatctc ctcctctatt
    24001 acctgcgtag tcctgtatgc gttgccggtc gggtggtaga cgcgaggtgg gcgatgttgg
    24061 cggcaggggt cctggtggtg ggcgtcttct cgggggtcgt gtcgaggtcc tggtagtcgg
    24121 tgccctgcat ggcttctccg accgtcctca ttgccgtcga aacagaccgc ggcgacctcg
    24181 tcgctcccgc ctagttacgc gtccagtcgt tcccgcaatg cgctgggcgg tgctggaggg
    24241 tggccgatgg acagggtcag gatgtcgcag ccgaggatcg gggcctggat ctcgggccag
    24301 gcgtcccgcc cgcccatgtc cgtcttcacc ccgggcctca cgtcgtggtc ggcgatccgg
    24361 atggtcttgc cgctgacgcc gtgctcggag agcgcggcca tggtctgctc ggcgagcagc
    24421 tgggagccgg acgcggcggg cgaggcggag cggggacgga cgagcgcgac agcgcggggg
    24481 cgtgtcggtg atggtcatgt gatccggcta cccggagcgc cgaccggtat cccacctcgg
    24541 gtaacaccac cggccgatgg agtgagcgca gggcacggct gaccgggccg gaaggcgatt
    24601 cggtctcgat cctgggggtt cacgaagtcc ccggctcgta gcggggaatc gctcgccgga
    24661 ccatgtcgcc caggatgaat catgaatcgg gctccaatgc ccatctgatt ctgcatggcg
    24721 ggcgaggcca accgatcttg tggaggcgat gggggcacgc ccggacccgc cgctgcacac
    24781 tgatctgctt gctggacgcg gtaggcgtca gttccgcgtc cccgcgcccg gctcagttcg
    24841 tgaccgccgt ggcgatgcgg cggtacctgt ctgccgcgct ggtcgcctcc cccgcatccc
    24901 gcgtggcggc ctgtcggcga tggggccctg ccacgacgct catcgccgcg gcatcccgcc
    24961 ggacccgacc gaaagggcct ggagaagtcc ggcgatggag ccggcgtacc gcatcagcgg
    25021 tgacgcccac ggctacgcca ccgccggcca cgtggtgcac ctgtcgctgt tcgacgcgat
    25081 gggacacgac atcgccgccg ggctgaccgt caacctggcg atgggcggtc gccgcaacgc
    25141 cctccgaggg tgcgcggggc tgctggagac cggcgagagg atcgaaacgg tgaccgctac
    25201 gtcaccggca cagccgcacg ggggtggttg tggggtgaat gtcgttaccg gtcgggggca
    25261 gggggcactg ataggcccgg gtcctgtccg cgtcggcggg atggcccaca cccgtgcaaa
    25321 cgaagacgag ggagtacgac ggatgacgaa ggctcgcgac atcatgacgg cggacgcaac
    25381 gtgtatcggc gcgaacgaga cggtgctcga ggccgcgaag aagatggccc ggctgaaggt
    25441 cggctcgttg ccgatctgcg gtacggacga gaagctcaag ggcgtgctca ccgaccggga
    25501 catcgtggtg aaggtcctcg cggcggacag ggaccccggc caggtgaagg cgggcgacct
    25561 cgcccagggc gaggccgtca ccatcggcgc cgacgacgac gccgcggaaa tcctgcgcac
    25621 gatgggcgca caccaggtcc gccgactccc cgtcatcgac gggcacacgc tcgtcggtat
    25681 cgtcgccttg gcggatgtcg cccgtgccct gccggacacg aaggtcggcg acctgctcga
    25741 agcgatctcc caggactgac cggcgacccg gccgagcctc tggaagcatg tctgagcccc
    25801 aaggcgctcg gcctcgtgat cgacctggaa ggtctcgatg ccgagatgag ccggccgccg
    25861 ttcggaccat gtttccggcc ctggaacagg tcagccggta cgaggtcgag cacggtcggc
    25921 cgatgctctc ggcgctggtc gtgtccgagg gttcaccggc gccgagccct ggctttgccg
    25981 acctcgcgcg gcacctcggg ctcgaggcgg cagatgacgc tgctcgaacg gagatccgct
    26041 tctggtacac gcagaccccg tcctcgtcct ggatgcggca acagatcgga tcatgagtga
    26101 gctccggacc atcaaggagg tgctgaggat gccaatagcg ttcgccgacg tgccaccggc
    26161 ctgctcgccc ggtggctcag ctcggtgacg ggcgcgcatg gaggttgcgc agggtcgcga
    26221 tgacggcatc gtcactgacc tggtcgaagt cgtcgtacca ctggcccacc gcgtggaagt
    26281 ccgtcggttc gtggaggcag atgatctcgt ccgcttcttc acgcatgagg tcggcggtgc
    26341 cggcggagcc gacgggcacc gcgaggatca gccggccggg atcctgtcgg cgcaggtggt
    26401 gcagggccgc acgtgcagtg acgcctgtgg cgagtccgtc gtcgacgagg atcacggtcc
    26461 gcccggtgac gctcggggcg ggccggccgt cgcggtagat ggcctcacgg cggtgcagct
    26521 cgaggcgttc acgggctacg tcggcgccga gtcggtcctc gctcaggccg agcatctcaa
    26581 gtacctgctc gtcgaacagg ggcgggtcgt cgcccgcgat cgcgccgatg ccgacctccg
    26641 gacgtccggg cagcccgatc ttgcgagcga ccaggacgtc caccggcgcc ttgagggcaa
    26701 gagcgaccgg tgctgcaacc ggtacgccgc cgcggggcag cgccaggaca agggtgtcgt
    26761 tcagatcgcc ggcggctgcc cattccagca gtcgagcggc gagttcctgg ccggcgtgcc
    26821 ggcggtcgtg gaaacgcatg gtctgatgcc tgcccttctt cccggggagc cggtgcgtgc
    26881 gcggggcgtg atcggcggga ttcacatgcc ggtgggccag gtctcctcct ctgccgtgtc
    26941 gggtgctgcc gcgtgcagcg gagtgagggc gcctgtggtg ccgatgaaag gaaggcgtcg
    27001 taccggtcgc cgaggacggt gctgacgtag ttgccccacc tctcgctctc cggccggtag
    27061 ccggtggtcg gaggcggtca ccgtgccgtg gtgggagccg aagcgcacca ggacgacgcc
    27121 ctgggcggcg tggcgttccc gtaccaactg cccgacgttg accatgccgg cagcggccat
    27181 gtccgtggcc cgggcgtcgc cgatgtgggt gttgtgttcc cacaccaccg ccttcgcgcc
    27241 gggaccgcgg tgctccacga gccggtccag ggtgtcggcc gccgcctgct cactgtggtg
    27301 ccgcagccgt gtcaggaggg ccagcacctc cggttcgcat cccgagggga tcagccgggt
    27361 ggcagagcgt agggctgcgg gtcctcggcg tacggctcga agcaccggta cgcctccggg
    27421 gcgtgctcga cttcggccgg ggcgtgtgag ccgagatagt cgaagaccgc gtgcagggac
    27481 tcccagagcg agtacacgtc caggccgaag aaccccaccc gccgttcggg tggcagctcg
    27541 gtgttgtgct cgcagccagc gggtgaagtc gagtacgtcg gtgttggccc acatccaggt
    27601 cggccagcgg ctgaatcccc gcagaacgtc ggccgggtcc tcgggcgcgc ccgctgcggc
    27661 ggtgaccgag cagtggacgg cctgacagtc cggccagtca ccctcgaccg cgacgaggga
    27721 gaaacccctc tcgccgatca gccgccgggt cagggcggcc cgccaccggt agaactcggc
    27781 cgtgccgtgg gaggcttcac cgagcagaac gtacctggcg tcgccgatcc gttccatcag
    27841 cggatcgagg gacccggggc ccgtcagcgg cagggcgctc tctcggatac cagccctttg
    27901 gtcgtcccgt ccctgcaagg tgatggccat cagcgctcgt tcccttcccg gcgaagggcc
    27961 gatggtgcgc tgcccgcagg ccgatgcgcg gcacagggca tggaccaggg gcggcgcacc
    28021 aatgagtacc gcataaccgt acgtctacct gggatacgtc actccaaacc agcggcgctc
    28081 tcagccgtag cgacaagggg ctggagcgta cgtccacgcc ggggaggtgg acgcgagcgc
    28141 cccaccgagc tcctttgatc acgcgctggg gaggtcgcgc ggcgggttca ccaccaacct
    28201 gcacctgtgc cgtcgagcat ggtccccgcc cacctcgacc gtggtgacgg cgggacaccg
    28261 cggggactcg ccgcagttcg aacccgcgcc ggagaaggtt cgcgtgcgcc tcatcggggc
    28321 caggccaacg ggaaggtcaa ggacgtctag gccgtctctt tcggatcttg tcggccgagc
    28381 ccgcggcgtc cgatgccgtg tccggcaagg cggaggggcg cccttgta
//
