LOCUS       NZ_BMVL01000002        20741 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces avidinii strain JCM 4726 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVL01000002
VERSION     NZ_BMVL01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces avidinii
  ORGANISM  Streptomyces avidinii
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 840996)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650695.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,659
            CDSs (total)                      :: 7,582
            Genes (coding)                    :: 7,337
            CDSs (with protein)               :: 7,337
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 80 of 245
            Pseudo Genes (incomplete)         :: 200 of 245
            Pseudo Genes (internal stop)      :: 10 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:19:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 164050
            Orig. end                         :: 184791
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVL01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20741
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="3"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20741
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20741
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10741](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10741
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            453..1226
                     /locus_tag="IE257_RS04840"
                     /old_locus_tag="GCM10010343_09870"
     CDS             453..1226
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262030.1"
                     /locus_tag="IE257_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09870"
                     /product="response regulator transcription factor"
                     /protein_id="WP_189965061.1"
                     /transl_table=11
                     /translation="MHALLVEDDDRMAQALGTALAQRGHTVRRVGRALDALRHVREAEF
                     VLLDLGLPDLDGLELLRRLRTVCAAPLIVVTARCEERDIVQGLRAGADDYVVKPFRMAE
                     LMARIDSVRRRTDPYPDRRPDPAASGARPVHTGDVVVDLAGRTVTVAGDEVRLTRREFD
                     VLAFLAARPDEVHSREEILDRIWGDAFLATSRSLDVHVAGIRAKTGRSGLVRTVRGFGY
                     RLGRPTAPDGEDGSGGGSGGGSGNMDEGGSGGGAR"
     gene            1223..2644
                     /locus_tag="IE257_RS04845"
                     /old_locus_tag="GCM10010343_09880"
     CDS             1223..2644
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="IE257_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09880"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_209468326.1"
                     /transl_table=11
                     /translation="MRRRLLVVLMVLMGAAAVLLCVPLADAYARGRTEHLLLQRRSEAV
                     RFADLADRMRTAADRAELSAEISRYAQLYGAGVVVVDTAGATVARAGTGPAERAASNAA
                     TDSASATGGPSEGADARRRALTGRSTDRLPTLRPWGPRTVVLAEPVGRDERVSGAVLMA
                     VPTDAARRDVAIRWSLITAGALAAFAAAALVAAGIARWLMRPVLDLDRAVERLTAGSLQ
                     ARAVSDTGPPELRHLRQHFNTMAQAMADSIGRQRDFVADASHQLRNPLATLVLQLENVE
                     PHIAPGPGLTEHSRALDEAERLEELLDGLLALARVESGTAELGDQDVTRAVRDRVTAWA
                     PVFRAAGVELVATGLAEGLRARALPDAAGRILDALLDNAVKFVPRGRRVEVHTAHGPEG
                     CAVVRVTDDGPGVPEAQPALLLRRFARAPEHQNVPGSGLGLAIADEIARISGGHLAVGG
                     NEPHGLVVEFRLPSP"
     gene            complement(2662..3693)
                     /locus_tag="IE257_RS04850"
                     /old_locus_tag="GCM10010343_09890"
     CDS             complement(2662..3693)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262032.1"
                     /locus_tag="IE257_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09890"
                     /product="TAXI family TRAP transporter solute-binding
                     subunit"
                     /protein_id="WP_229920125.1"
                     /transl_table=11
                     /translation="MTSAEVTRRRMMGAGLGALVGALAGCSGDSGPVRRLRLATGPEGG
                     PYNAFGQALAQAVAASGRRIEIVPVSTAASVNNLRKLDEGSVELALAMADVAEDAVLGR
                     ESFPRPTPVTALARVYVNYTHLVVPADGPVRSVRDLAGRPVAAGAAGSGVQVVTERVLR
                     AAGLSGPPGPAPAPGPASPSAPAPAPASAEAADERALGLAASVSALREGSVDALFWSGG
                     VPTAALAELARELPLRFLPLDDYVGPLRERYGPVYTAVTLPAGVYGPTEPVGTIGVGNY
                     LMARADVPQDAVRDLLRVVFDRWRDLLREVTAGARLEPRFAISTGEVPLHPGAVAHYRS
                     VYG"
     gene            complement(3717..3923)
                     /locus_tag="IE257_RS39090"
                     /old_locus_tag="GCM10010343_09900"
     CDS             complement(3717..3923)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025691.5"
                     /locus_tag="IE257_RS39090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09900"
                     /product="DUF4389 domain-containing protein"
                     /protein_id="WP_308277832.1"
                     /transl_table=11
                     /translation="MLSLVAVVILMRTGTYPRGLFDLLMGLMRWMLRVLVYAALMTDEY
                     PPFRLDMGGSEPAAGRLEPAPAG"
     gene            complement(3899..4405)
                     /locus_tag="IE257_RS04855"
                     /old_locus_tag="GCM10010343_09910"
     CDS             complement(3899..4405)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025691.5"
                     /locus_tag="IE257_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09910"
                     /product="DUF4389 domain-containing protein"
                     /protein_id="WP_308277833.1"
                     /transl_table=11
                     /translation="MFPDSPNPLSVEAALDPELTRWMWLVKWLLAIPHYFTLILLQVAF
                     VPVTVIAFFGIIGTGRYPRPLFDFNVGVIRWSTRVSYYSSVVLGTDSYPPFTLKDVPDY
                     PIRVDVTYPERLSRGLVLVKWLLVVPQLLVTMLLVTSGWTATGTWPTTVRSPRGSSVCS
                     PSSPW"
     misc_feature    4725..4737
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            4725..5075
                     /locus_tag="IE257_RS04860"
                     /old_locus_tag="GCM10010343_09920"
     CDS             4725..5075
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_09920"
                     /product="hypothetical protein"
                     /protein_id="WP_189965064.1"
                     /transl_table=11
                     /translation="MHIATIIAASFTAACTGIAYFHYTSTMNPNRHIPLFCPRFPNVPL
                     WVDLVCCPAWWASGTVLCLAMPLWPGLALYCAAALPPMEIMRRRHNRRVGRPVSAISGA
                     RDPGSGTSRSAG"
     misc_feature    4744..4759
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(5417..5430)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.79"
                     /tool="antismash"
     misc_feature    complement(5573..5588)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.33"
                     /tool="antismash"
     misc_feature    complement(5754..5770)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.14"
                     /tool="antismash"
     gene            5756..6580
                     /locus_tag="IE257_RS04865"
                     /old_locus_tag="GCM10010343_09930"
     CDS             5756..6580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090789.1"
                     /locus_tag="IE257_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09930"
                     /product="hypothetical protein"
                     /protein_id="WP_229920126.1"
                     /transl_table=11
                     /translation="MIVKRAGRLVVVAAIPAAVFLTLGLSGPALAQGGKAYQIDLAQLN
                     DSGSRGTVMLTLKGNQLTVQIESEGMVPGQPSAQHLHGSTKGHDFHCPDKTDDTDGDGV
                     LSNTEATHDYGDINISLTTGGDTKATSGLDVQRMPVADKQGTIRYKRTIAVGQDVVDHI
                     KDLHVVQHGIDRNNNKKYDFEGAGKSELDPKLPQEATAPTNCGEVKGAAVGSVPVGGIE
                     TGGGTPEQPTVSVTMRDGVAITVLAAVAGAVILGRNRAAAVPGRKETTGGGA"
     gene            6577..7329
                     /locus_tag="IE257_RS04870"
                     /old_locus_tag="GCM10010343_09940"
     CDS             6577..7329
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957115.1"
                     /locus_tag="IE257_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09940"
                     /product="class F sortase"
                     /protein_id="WP_189965065.1"
                     /transl_table=11
                     /translation="MKSTPVLTAAAAGSAGRRPRRRTAVPVAAAAAALAGLLLAGCGGQ
                     NAAKPPTSAEQPQPAGAPAAAGGAPTAKAPAGGNSAPPADGSQSGTGGGAGGAALARSE
                     PQKITIPSLNVSSSLETLAQNADGTMQTPKDPALAGWYEPGPTPGSQGPAVIAGHVTWN
                     GASAVFEKLKTMKGGDTIKVTRRDGKTVTFTVDRVAEYPKAEFPTLEVYKNLDHAGLRL
                     VTCGGSFDPAKHYYDSNVVVFARMTGAA"
     gene            7456..8325
                     /locus_tag="IE257_RS04875"
                     /old_locus_tag="GCM10010343_09960"
     CDS             7456..8325
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020552184.1"
                     /locus_tag="IE257_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09960"
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="WP_189965067.1"
                     /transl_table=11
                     /translation="MRFHHVDVFTDRPFNGNSLAVFPDADALTGAQMLAITRELRHFES
                     VFLLGEGTSGPHVRRARVFDLAGELEFAGHPLLGAAAVLHALHGAADHEAWTLRLTARS
                     VEVTTDRRGPGRYASLLDQGAAAFLGRPDPDGLAALFDLEPGDLDADLPPEVVSTGLSY
                     LVLPVRGDALARARVTAPLDEPLARLGAEYAYLLDTAAMEGRHWTNDGVLEDVATGSGA
                     GCAAAYLRSHGRIGAGQERLLRQGRHTGRTGEMTVSAEGDGRTIHSVRVGGGVALVAEG
                     RLRALPPA"
     misc_feature    complement(8413..8428)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            8474..9739
                     /locus_tag="IE257_RS04880"
                     /old_locus_tag="GCM10010343_09970"
     CDS             8474..9739
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670668.1"
                     /locus_tag="IE257_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09970"
                     /product="serine hydrolase"
                     /protein_id="WP_189965069.1"
                     /transl_table=11
                     /translation="MKPTHIRLRRACAAAAAAGILLTPAVAGSAYAAPVPGPSAPIAAA
                     PTPTPVPTSTPSPDTDTVFRQITPAVAAQLDAAVRQVMREAQVPGVTVGLWAPGKGSYV
                     RSFGVADKATGAPMRPDLHVRIGSETKTFTVTALLQLVDQGKVGLDDRIGDYITGVPNG
                     DRITLRQLAGMRSGLFNYSMDGDFITRLEKNPELPMSPRQLLDYSFRHPVLFEPGAEFD
                     YSNTNLILLGLVVEKITGRPLHEVIAKDVVAPAGLRSTVFPTNAAIPAPYAHGYTNQTA
                     SGKVEDSTHWNPSWAWAAGAMISDLQDLRSWARTLAVGTLLKPATQAERLKTTPMDIPG
                     AGYGLGIFDVQGWIGHNGSIPGYEVLPVHLPAADATMVILLNTDSQYKGQEPSTLFGEA
                     VTGIVTPDHVYPGHKPVVPRTG"
     misc_feature    complement(9983..10002)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.5"
                     /tool="antismash"
     gene            10001..10741
                     /locus_tag="IE257_RS04885"
                     /old_locus_tag="GCM10010343_09980"
     CDS             10001..10741
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="IE257_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09980"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_078626157.1"
                     /sec_met_domain="CDPS (E-value: 5.1e-87, bitscore: 286.8,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLAAQRTRPLLTTATEVFTVRPYTPHCQVISTEGDHAVIGISPG
                     NSYFSAQRVIDLAHWGMRNFEQVDLIYTDLHVAEMYEALGYGEDEARRKAVKNLRGVRA
                     KVNNAAAEADPTGARLRARPMSSLTDIPAYRTLHNHLTNLLDIDPEFRETCNSLVDVFL
                     SSKVLGGEAATTRQRDVCLEYVCAEAPLFLDTPAILGVPSSLNCYHQLLPMAELLYSRG
                     SGLRASRNQGHAIITPAEGVPDVH"
     gene            10731..11915
                     /locus_tag="IE257_RS04890"
                     /old_locus_tag="GCM10010343_09990"
     CDS             10731..11915
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999282.1"
                     /locus_tag="IE257_RS04890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_09990"
                     /product="cytochrome P450"
                     /protein_id="WP_189965071.1"
                     /sec_met_domain="p450 (E-value: 1.7e-16, bitscore: 55.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDTLLDFPFSARGDQLPPEIEELRSEPVKRVRTIAGDEAWLVS
                     SYPLAKQVLEDPRFSLKDTSAPGVPRQYALTIPPEVVNNMGNITGAGLRKAVLKAINPK
                     TDGLTDWMRAQATTLVDNLLSHGAPVDLRGLFTNPYAENLHCRILGIPEADAPRLAASL
                     DIAFMNSACPVTGAKLNWDRDIAYMVERLDDPTTTGLIAELAALRNDPAYDHLTDEMLA
                     TVGVTLFGAGVISTMGFLTMAIVSLLQHPEMWERLRKEPEKIPAAVDELLRINLSIADG
                     LPRLALEDLTLGDVEVKKGELMLVLVEAANTDPDVYPDPHVADIDRPNAGTHLSFGGGQ
                     HYCPATALGKRHTEIAIEVLLEKMPNLALAVPVDQLVWRTRFMKRLPERLPVLW"
     gene            complement(12076..12903)
                     /locus_tag="IE257_RS04895"
                     /old_locus_tag="GCM10010343_10000"
     CDS             complement(12076..12903)
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-262). E-value:
                     2.9e-27. Score: 87.8. Matches aSDomain:
                     nrpspksdomains_IE257_RS04895_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059054.1"
                     /locus_tag="IE257_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10000"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_189965073.1"
                     /sec_met_domain="PF00561 (E-value: 2.2e-22, bitscore: 75.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.2e-17, bitscore:
                     58.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFTAPDGTRLAYRIHGDGDPLLCVPGGPADSSYLGDLGGLSAH
                     RRLIVPDLRGTGRSAVPADTSSYRCDRLVEDIEALRAHLGLARTDLLAHSAGANPATQY
                     LARYPDRVRRLALITPGTRAVGLTISAEARREVARLRRDEPWYPAAFAALEAITEGTGS
                     DWEAVSPFFHGRWDAAARRHQAASRPDNTEAVTLFAAEGAFDPQATRAALAGCRTAVLL
                     LAGEFDVNSPPRSVAESAALFPGATFVVQRGAGHYPWLDDAERFVASTAAFLA"
     aSDomain        complement(12118..12840)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE257_RS04895_Abhydrolase_1.1"
                     /evalue="2.90E-27"
                     /label="IE257_RS04895_Abhydrolase_1.1"
                     /locus_tag="IE257_RS04895"
                     /protein_end="262"
                     /protein_start="21"
                     /score="87.8"
                     /tool="antismash"
                     /translation="PLLCVPGGPADSSYLGDLGGLSAHRRLIVPDLRGTGRSAVPADTS
                     SYRCDRLVEDIEALRAHLGLARTDLLAHSAGANPATQYLARYPDRVRRLALITPGTRAV
                     GLTISAEARREVARLRRDEPWYPAAFAALEAITEGTGSDWEAVSPFFHGRWDAAARRHQ
                     AASRPDNTEAVTLFAAEGAFDPQATRAALAGCRTAVLLLAGEFDVNSPPRSVAESAALF
                     PGATFVVQRGAGHYPWLDD"
     misc_feature    12886..12902
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.86"
                     /tool="antismash"
     misc_feature    12926..12944
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    complement(12927..12945)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            12981..13658
                     /locus_tag="IE257_RS04900"
                     /old_locus_tag="GCM10010343_10010"
     CDS             12981..13658
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158227.1"
                     /locus_tag="IE257_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10010"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_189965075.1"
                     /transl_table=11
                     /translation="MTEPESESAHRQSGTSATDGTPATLTEEQAVRMLAGMNEVIRAGE
                     EMRRLRAEMIKLFAGFGWTQDRIARIADMSQPAVSKQVAKYAVDAPARPMTLALGQYDG
                     PWLEGRLWGLAEVVAETIDGARCARYVDALARGRKRFTPRNVDELRRLLEEDLRLRRAE
                     LSDDFRAAYDEIGRGLDDPPKGPAGTTSPVSAPVSASASVRRTLAHQLQRDRLEAGRPP
                     GGS"
     gene            13776..14207
                     /locus_tag="IE257_RS04905"
                     /old_locus_tag="GCM10010343_10020"
     CDS             13776..14207
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669541.1"
                     /locus_tag="IE257_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10020"
                     /product="DUF2690 domain-containing protein"
                     /protein_id="WP_189965077.1"
                     /transl_table=11
                     /translation="MKARILAASLSAGALLATGLLAAPTASAAAAAPSCVGSACNGKNP
                     AGTSCQNDARTVAESGDPMGAMELRYSPSCRAAWGRFKINAPSGSRIEIKNNQGKKYTT
                     SGTGKFYSVMINDKDVKAWACGIWPSEFGGTNTACTEDY"
     gene            14207..14641
                     /locus_tag="IE257_RS04910"
                     /old_locus_tag="GCM10010343_10030"
     CDS             14207..14641
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_10030"
                     /product="hypothetical protein"
                     /protein_id="WP_189965079.1"
                     /transl_table=11
                     /translation="MGRRAAKTTRTDPLGGARRRLLVTGAALVGTLALATGPALATTAN
                     VGGQVGGSSTYYGTARTVTADGSHICLRADSGGIAMKAFWYKCSDRSTRGADREVGSGT
                     RQRLGSGFKAGTVYCLGAAADVVSPNKTSWSGTLDWNVFS"
     gene            complement(14718..15728)
                     /locus_tag="IE257_RS04915"
                     /old_locus_tag="GCM10010343_10040"
     CDS             complement(14718..15728)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955806.1"
                     /locus_tag="IE257_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10040"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_229920127.1"
                     /transl_table=11
                     /translation="MGEENAGMLSALGLDTPTEAVYRLLATRPEGWGVGQMAEQLGLEE
                     QQVRDALDRLAELALLRRSADRPGGWRAIHPELGLQLLLRRRQEELERRRRELDDTHVA
                     VTRMIADCAGPAVGGAEPDSERLIGMDAIRSRLEQVANKATDSVCTFMPGGGHSPASIE
                     AARHNDAQILLRGVEVRTVCLDSVRNSAPTLAYARWLTENGGEVRTVPTLPLRMILIDG
                     TSALVPLDPSDTRRGAVLLHTAGAMTALSRLFEQVWAVGLPLGAQQPRHEGTGLTAQER
                     ELLTLLAKGLTDETAAGRLGVSLSTVRRSMASIMERLGARSRFEAGLRAAQAAWL"
     gene            complement(15808..16218)
                     /locus_tag="IE257_RS04920"
     CDS             complement(15808..16218)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024242.5"
                     /locus_tag="IE257_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_189965081.1"
                     /transl_table=11
                     /translation="MTSRATSCWSALLVEFRRGADGRPEALTAISRQVGWSDRHLRACF
                     GQQVGLAPKAVARVARLQRALRLQALGLDGAAVAASGGFHDQAHCIREFKAMTGLTPSQ
                     FAARRGGLRPGSPLDRVAGRVTSLLLPDTATD"
     gene            16221..16736
                     /locus_tag="IE257_RS04925"
                     /old_locus_tag="GCM10010343_10070"
     CDS             16221..16736
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE257_RS04925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010343_10070"
                     /product="hypothetical protein"
                     /protein_id="WP_189965083.1"
                     /transl_table=11
                     /translation="MKSFAALGVFVVGLSALLSGCADGPRSAAATELLDRQGYDAVLRR
                     SSLSYRWPADYRPDLDRLSADSAPGGGEAALAGSERIILEIANSCAWYRSWDDARGRAD
                     HARAEEALTVLEEVLPGYGPQNPDGRRYAREAASRARAGDPSLARQFTEANCDGVIAWD
                     RTGIDAEG"
     misc_feature    complement(16766..16780)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.38"
                     /tool="antismash"
     gene            16774..17223
                     /locus_tag="IE257_RS04930"
                     /old_locus_tag="GCM10010343_10080"
     CDS             16774..17223
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="IE257_RS04930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10080"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_229920128.1"
                     /transl_table=11
                     /translation="MTTTGAGAGAGAGAGTASPVGAGAGGRTPPVLRLYHELLADRERL
                     IEAHHRLLAEQNALLEQIDLLCARSTAAGSDTPCGSPPPLSPVQRQVLVLMAGGAKDGA
                     IARRLNLSERSVRRQVESLTRRTGASNRFTLALAAIRIGWLPAGR"
     gene            17354..17884
                     /locus_tag="IE257_RS04935"
                     /old_locus_tag="GCM10010343_10100"
     CDS             17354..17884
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153864.1"
                     /locus_tag="IE257_RS04935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10100"
                     /product="hypothetical protein"
                     /protein_id="WP_189965087.1"
                     /transl_table=11
                     /translation="MRSRVRSTLATSLVGTTAALVALLVPGTAHAAPAKLSHSSAVSKL
                     NATGGIGLSSSGGCSNRNNSTCTSLEQVNAASISDVITLRKASNCTLTITGGTEVGHAS
                     GTYSHWNGYKIDFSPTSCVSNYVTSSFTRIANRGDGAARYRSAAGNVYARESNHWDVTF
                     CGGSSACTSAASS"
     gene            complement(17955..18854)
                     /locus_tag="IE257_RS04940"
                     /old_locus_tag="GCM10010343_10110"
     CDS             complement(17955..18854)
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539017.1"
                     /locus_tag="IE257_RS04940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010343_10110"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_209468327.1"
                     /sec_met_domain="APH (E-value: 5.2e-34, bitscore: 113.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAQMHPGAHPVDEHLVRRLIAGQFPQWAASAVERIPSGGTVNV
                     MYRLGDTMVVRLPMLAGGAADVSMEQEWLPRLAPRLPTAVPEVLGAGEPAHGYPWAWSV
                     YRWLPGENPRAGGLTEPEALAADLAGFVAAMRSVTLPGAPRAHRGGPPASLDAATRAAI
                     GQLRGIPQEGVDCDAVTAVWEDALRAPAPDGPPVWLHADLMPGNLLISGGRLSSVIDFG
                     CMGVGDPACDLFPAWNPLPAGARTVFREALGVDDATWRRGRGRTLSQAVIALPYYRTTN
                     PAMADNARHVIRAVLEED"
ORIGIN
        1 ggccgaactg ttccccacgc gggtgcgcgc gctgggcgtg gcactgccgt acgcgatcgc
       61 caacgcgctc ttcggcggca cggcggagta cgtcgcgctc tggttcaaga acagtgggca
      121 cgagaccatg ttcttctggt acgtctccgg gtgcgcgctg atctccctcg tgacctacgt
      181 gctcatgccg gacacccgca atgccgcgct cagccgcgcc gaggccgagg cagacgggga
      241 cggggacggg gacggggacg gcaaggatga cccgggccgg tccgcggtcg ctcccgccga
      301 ggccgcacgc tgacccgtcc cggcgatccg ttccgctgct ccgttccgct gctccgtccc
      361 ggtgacccgg cgcgtcggct cccgtaagct gctgcgccgg gtcacgggga tccggtgatg
      421 cgggtccggt ccaggtcgca aggaaaccgt ctatgcacgc gctgctcgtc gaggacgacg
      481 atcgcatggc ccaggcactc ggcacggcgc tcgcccagcg cgggcacacc gtccgccgcg
      541 tcggccgcgc cctggacgca ctgcggcacg tccgcgaggc cgagttcgtc ctcctcgacc
      601 tcgggctgcc cgacctcgac ggactggagc tgctgcggcg gctgcgtacc gtgtgcgccg
      661 cgccactgat cgtggtgacc gcgcgctgcg aggaacgcga catcgtgcag ggactgcgcg
      721 cgggcgccga cgactacgtg gtcaagccgt tccgcatggc cgaactgatg gcccgtatcg
      781 actccgtacg acgccggacc gacccctacc ccgaccgccg gccggacccc gccgcgagcg
      841 gcgcccggcc cgtgcacacc ggtgacgtcg tggtggacct ggcgggccgg accgtcacgg
      901 tggcgggcga cgaagtacgg ctgacacgac gcgagttcga cgtactcgcc ttcctggccg
      961 cccgcccgga cgaagtgcat tcccgcgagg agatcctgga ccggatctgg ggtgacgcct
     1021 tcctcgcgac ctcccgctcc ctggacgtcc acgtggcggg catccgcgcc aagaccgggc
     1081 ggtccggcct ggttcgcacc gtccgcgggt tcggctaccg gctcggccgg ccgaccgcgc
     1141 cggacggaga ggacggaagc gggggcggaa gcgggggcgg gagcgggaac atggacgagg
     1201 gcggcagcgg gggcggcgcg cggtgaggcg ccggctcctg gtggtgctga tggtgctcat
     1261 gggggcggca gccgtgctgc tctgtgtccc cctggccgat gcctacgcgc gcgggcgcac
     1321 cgagcacctg ctcctgcagc ggcgttcgga ggcggtccgg ttcgccgatc tcgccgaccg
     1381 gatgcgcacc gccgcggacc gggcggagct ctcggccgag atcagccggt acgcgcagtt
     1441 gtacggtgcc ggggtcgtcg tggtcgacac cgcgggagcg acggtggccc gggccgggac
     1501 cggacccgcg gaacgggccg cttcgaacgc ggccaccgac agcgcttccg ccacgggcgg
     1561 cccctccgaa ggtgcggacg cccgtcgccg tgccctgacc ggccgctcca ccgaccggct
     1621 gcccaccctt cgcccctggg gtccgcgcac ggtcgtgctc gccgaaccgg tggggcggga
     1681 cgagcgggtg agcggggcgg tcctgatggc cgttcccacc gacgccgcac gccgggacgt
     1741 ggcgatccgc tggtcgctca tcaccgccgg ggcgctggcg gccttcgcgg cggcggccct
     1801 ggtcgcggcc gggatcgcac gttggctgat gcgcccggtg ctggacctgg accgggcggt
     1861 cgagcggctg accgccggca gcctgcaggc ccgggccgtg tccgacaccg gtccgccgga
     1921 actgcgccat ctgcggcagc acttcaacac catggcgcag gccatggccg actccatcgg
     1981 ccgccagcgc gacttcgtcg ccgatgcctc ccaccagctt cgcaacccgc tggccaccct
     2041 ggtgcttcag ctggagaacg tcgaaccgca catcgcaccc gggcccggcc tgaccgagca
     2101 cagccgcgcg ctggacgagg ccgaacgcct ggaggaactg ctcgacggcc tgctggcact
     2161 ggcccgtgtg gagtcgggca cggcggagct gggcgatcag gacgtcaccc gggcggtacg
     2221 ggaccgggtc acggcctggg ccccggtctt ccgcgccgcg ggggtggaac tggtggcgac
     2281 cggcctcgcg gaggggctgc gggcgcgcgc cctgcccgac gcggcgggcc ggatcctcga
     2341 cgcgctcctc gacaacgccg tcaagttcgt cccgcgcggg cgccgcgtcg aggtgcacac
     2401 cgcgcacggg ccggaaggct gcgccgtcgt acgggtcacg gacgacggcc cgggcgttcc
     2461 ggaggcgcaa ccggctttgc tgctgcggcg cttcgcccgc gccccggagc accagaacgt
     2521 ccccggaagt ggtctggggc tggccatcgc cgacgagatc gcccggatca gcggcgggca
     2581 cctcgcggtc ggcggcaacg agccgcacgg cctggtggtc gagttccggc tcccgtcgcc
     2641 ctgagccggc cccgggcgtc ctcagccgta caccgaccgg tagtgcgcga ccgcgccggg
     2701 gtggagcggt acctcgccgg tggagatggc gaaccggggc tccagccgcg cccccgccgt
     2761 cacctcccgc agcaggtcgc gccaccggtc gaacaccacc cggagcaggt cgcgtaccgc
     2821 gtcctgcggt acgtccgccc gcgccatcag gtagttgccg accccgatgg tccccaccgg
     2881 ctcggtcggc ccgtacaccc cggccggaag ggtgaccgcc gtgtagacgg ggccgtagcg
     2941 ctcgcggagc gggcccacgt agtcgtcgag cggcaggaac cgcagcggaa gctcgcgcgc
     3001 cagttcggcc agcgccgctg tcggcacccc tccggaccag aacagtgcgt cgaccgagcc
     3061 ctcgcgcagg gcgctcaccg atgcggcgag gcccagggcg cgctcgtccg cggcctccgc
     3121 cgaagcgggt gcgggtgcgg gtgcggaagg ggatgccggt ccgggcgcgg gtgcgggtcc
     3181 gggcgggccg ctcaggccgg ccgcccgcag gacccgttcc gtcaccacct ggaccccgga
     3241 gccggccgcg cccgccgcga ccgggcgacc ggcgaggtcc ctgaccgagc gcaccggccc
     3301 gtccgccggg acgaccaggt gcgtgtagtt cacgtagacc cgggccagtg cggtcacggg
     3361 ggtgggccgg ggaaacgact cccgccccag cacggcgtcc tcggccacgt ccgccatggc
     3421 cagtgccagc tcgacggagc cctcgtcgag cttgcgcagg ttgttcacgc tggccgcggt
     3481 gctcaccggg acgatctcga tcctgcggcc gctcgcggcg acggcctgcg ccagggcctg
     3541 cccgaaagcg ttgtacggcc cgccctcggg tcccgtcgcg agccgtagcc ggcgtaccgg
     3601 accggaatcc cccgagcagc cggccagcgc ccccaccagg gcgccgagtc cggcacccat
     3661 catccgtcgc cgggtcactt ccgcgctggt cacagcagaa gcctagaccg tcctcgtcac
     3721 ccggcggggg ccggctccaa cctgccggca gcgggctcgc tccctcccat gtccagccgg
     3781 aacggcgggt actcgtcggt catgagggcc gcgtagacga gcacccgcag catccaccgc
     3841 atcagaccca tgagcaggtc gaacagcccc cgcggatagg tcccggtgcg catcaggatc
     3901 accacggcga cgagggagag cacaccgacg agccccgagg agaacggact gtagtcggcc
     3961 aggtaccggt agcagtccag ccgctggtga ccagcagcat ggtcaccaaa agctgcggga
     4021 cgaccagcag ccacttgacc agaaccagcc cgcgggacag gcgctcgggg taggtgacgt
     4081 cgacacggat cgggtagtcg ggcacgtcct tgagggtgaa cggcgggtac gagtccgtgc
     4141 cgagcacgac ggaggagtag taactgaccc gcgtggacca gcggatgacg ccgacattga
     4201 agtcgaagag cggtcgtgga tatctgcctg tgccgatgat gccgaagaac gcgatgacgg
     4261 tcaccggaac gaatgcgacc tgcaggagta tcagggtgaa atagtgcggg atggcgagga
     4321 gccacttcac cagccacatc catcgggtga gctcgggatc cagggccgcc tcgacgctca
     4381 gcgggttcgg ggaatcgggg aacattgcgg tcaaatcctc tgtctcgcgc ggggcgcggc
     4441 aaaggcggcc cgcaattcac ggggcccggg gtgagccgaa ttccattagg cctcgatccc
     4501 tccctgcgca cctgccacgg gactgcgtag cacgagaacg cgtgacttga cggatggctg
     4561 ccgccctggt gccggggcct tctccaccgg cccgaccggc cgagacgcga ggaggcccgg
     4621 agaccgcgga tgtcaagcca cgacatcacg gggcatgacg cgtggcgttc cggccggttt
     4681 tcctgaccgc gggaggaaat ccgcacgtgg gaaaggagac tcccatgcat attgcgacga
     4741 tcattgccgc ctctttcacc gcggcctgca ccggcatcgc ctatttccac tacacctcga
     4801 cgatgaaccc gaatcggcac atccccctgt tctgcccccg attcccgaac gttccgctgt
     4861 gggtcgacct ggtctgctgc ccggcctggt gggcgagcgg gaccgtgctc tgtctcgcca
     4921 tgccgttgtg gccgggcctg gccctctatt gcgcggcggc gctgccgccc atggagatca
     4981 tgcgccgccg tcacaaccgc cgggtcggca gacccgtctc cgcgatcagc ggtgcgcggg
     5041 atccggggtc gggtacttcc cggtccgccg gttgatgcgg gcgcagccgg cgcacccggc
     5101 gcacgcatcg ggggtgagcg acggtacggc tgcggtgggg ccgcagcacc acacggtggc
     5161 ggccccgaag gcggcgtgca cggccggcaa cccccgggcc ggggctcggg ccggggcccc
     5221 ggcccgtgcg aggccgcagc tccgaccgag gccgcgctcc gctcactcgc cgtgatcggc
     5281 cccgacagca tttcttagca tcggaggcca actattcgcc cggtcacctc cgggacgact
     5341 agaaaggtcg ggaccgaacc ggagccggcg atggggtgat gccacccatc gacgatcaga
     5401 gcgatgtcga aggcggtgca tgtgcgtgcg ttggtgcggg cggatcgaat tgattgcggt
     5461 cttccccgac ctctcctggc acgttcgact gagaggtctg ttcatcgcac tccgcatcga
     5521 gctctggctc ggggaaggcc gctgacatgc ggcgttcgga gatctactgc gtgctcacac
     5581 gtgtaagtgc acagcgttga tcccatggcg caacagtcgc ctgaatttct tcaaatgggc
     5641 acccatccgc aggcgttgcg gcaccgaagg aggaaagaga gcctctccag gggctccttt
     5701 ccatcccgta cgaactgcga ttcccgtccc ggggatccac ggaacaggag cgaatgtgat
     5761 agtcaagcgc gccggtcgcc tcgtggttgt cgccgccata cccgccgccg tgttcctgac
     5821 gctcggcctt tccggaccag ctctcgcgca gggcggaaag gcgtaccaga tcgacctggc
     5881 gcagctgaac gattcaggct cccgcggcac ggtcatgctc accctcaagg gcaatcaact
     5941 gaccgtgcag atcgagtccg agggcatggt gccgggacag ccgtcggcac agcacctgca
     6001 cggttcgacg aaggggcacg acttccactg cccggacaag accgacgaca ccgacggcga
     6061 cggggtcctc agcaacaccg aggccacgca cgactacggc gacatcaaca tctcgctgac
     6121 cacgggcggg gacaccaagg ccaccagtgg cctcgacgtg cagcgcatgc ccgtcgccga
     6181 caagcagggc acgatccgct acaagcggac gatcgccgtc ggccaggacg tggtcgacca
     6241 catcaaggac ctgcacgtcg tgcagcacgg catcgaccgc aacaacaaca agaagtacga
     6301 cttcgagggg gcgggcaaga gcgagctcga cccgaagctg ccccaggagg ccacggctcc
     6361 gaccaactgc ggcgaggtca agggcgcggc cgtggggtcc gttcccgtcg gcggcatcga
     6421 aacgggtggc ggtacgccgg agcagcccac ggtgtcggtg acgatgcgcg acggtgtggc
     6481 gatcaccgtt ctcgcggcgg tggccggcgc ggtgatcctc gggcggaatc gggccgctgc
     6541 ggtccccggc cgcaaggaga ccaccggagg cggcgcgtga agtcgacccc cgtcctcacc
     6601 gcagcagctg ccgggtcggc cgggcggcgg ccccgccgcc ggaccgcggt tcccgtggcg
     6661 gcggccgcgg ccgccctcgc cgggctcctc ctggcggggt gcggcggcca gaacgcggcg
     6721 aagcccccca cgtcggcgga gcagccccag cctgccgggg caccggccgc cgccggcggt
     6781 gctccgaccg cgaaggcgcc cgccggcggc aattccgcgc cccccgcaga cggatcccag
     6841 agcggtacgg gaggcggtgc cggcggggcc gccctggccc ggtcggagcc gcagaagatc
     6901 acgatcccct ccctcaacgt gtcgagctca ctggagacgt tggcgcagaa cgcggacggc
     6961 accatgcaga ccccgaagga ccccgctctg gcgggctggt acgagccggg gccgaccccc
     7021 ggctcccagg ggccggccgt gatcgcggga catgtcacct ggaacggagc ctccgccgtg
     7081 ttcgagaagc tgaagacgat gaagggtggt gacaccatca aggtgacccg gcgggacggc
     7141 aagacggtca cgttcacggt ggaccgggtg gccgagtacc cgaaggccga gttccccacg
     7201 ctggaggtct acaagaacct cgaccacgcg ggccttcgcc tggtcacctg cggcggcagc
     7261 ttcgaccctg ccaagcacta ctacgacagc aacgtggtgg tgttcgcccg gatgacgggt
     7321 gccgcgtagc cggaaacggc cgggccggag gtatgcccgt cggtcgcagg gccccactgc
     7381 gaccgacggg cacccgcacg ggtccggatg cgggcccggg cctcatgccc gagggcgccc
     7441 ggtagcgtcg ccgccatgcg cttccaccac gtcgacgtct tcaccgaccg tcccttcaac
     7501 ggcaacagcc tcgcggtgtt cccggacgcc gatgcgctga ccggcgccca gatgctcgcc
     7561 atcacccggg aactgcggca cttcgagtcc gtcttcctcc tcggcgaggg cacgtccggg
     7621 ccgcacgtcc ggcgggcgcg ggtcttcgac ctcgcggggg agctggagtt cgccggacac
     7681 ccccttctcg gtgcggccgc ggtcctgcac gccctccacg gcgccgcgga ccacgaggcc
     7741 tggaccctgc gtctgacggc ccgttcggtg gaggtcacca ccgaccgccg cggcccgggg
     7801 cggtacgcga gcctcctcga tcagggcgcc gccgccttcc tcggccgccc ggacccggac
     7861 gggctggccg ccctgttcga cctcgaaccg ggtgatctgg atgccgatct gcccccggag
     7921 gtggtctcca cgggcctgag ctacctggtg ctccccgtac gcggtgacgc tctcgcccgc
     7981 gcccgcgtca ccgcaccgct ggacgagccc ctggcccgtc tgggcgccga gtacgcgtac
     8041 ctgctggaca ccgcggccat ggaggggcgg cactggacca acgacggggt tctggaggac
     8101 gtggccaccg gcagtggtgc gggctgcgcg gccgcctacc tgcgctccca cggccggatc
     8161 ggcgccgggc aggagaggct gctccggcag ggccgtcaca ccgggcggac cggtgagatg
     8221 accgtcagtg ccgaggggga cggccgcacc atccactcgg tacgcgtcgg aggcggcgtc
     8281 gccctcgtcg cggagggacg tctgcgcgcg ctcccgccgg cctgagccgt ccggaggcgc
     8341 gccgctctcc atcgcggcca tcgcggccac cacagccccc acggccccca ccacggctca
     8401 cctcgcgacc cgggtggtcc ggacctacgc tgatggtgtt gcccggggcc ctcggacggc
     8461 aggagaccat gcggtgaaac caacccacat ccggctgcgc cgggcctgcg cggccgctgc
     8521 cgcggcaggg atcctcctca ccccggcggt cgcgggatcc gcctacgcgg cgcccgtccc
     8581 ggggccgtcc gcccccatcg ccgccgcacc gaccccgacg ccggtcccca cctccacccc
     8641 gtccccggac accgacacgg tgttccggca gatcacaccc gcggtcgcgg cgcagctgga
     8701 cgcggccgtg cgtcaggtca tgcgcgaggc acaggtgccg ggcgtgacgg tcggcctgtg
     8761 ggcgcccggc aaggggagct acgtccgctc cttcggcgtg gccgacaagg cgaccggggc
     8821 gcccatgcgg cccgacctcc acgtgcgcat cggcagtgag accaagacgt tcaccgtgac
     8881 cgccctgctc cagctggtcg accagggaaa ggtcggcctg gacgaccgca tcggcgacta
     8941 catcaccggg gttccgaacg gtgaccgcat caccctgcgc caactggcgg gtatgcgcag
     9001 cgggctgttc aactacagca tggacgggga cttcatcacg aggctggaga agaatccgga
     9061 actgccgatg tcaccgaggc agttgctcga ctactccttc cggcaccccg tcctgttcga
     9121 gccgggcgcg gagttcgact acagcaacac caacctgatc ctgctcggcc tggtggtgga
     9181 gaagatcacc ggccggccgc tgcacgaggt catcgccaag gacgtggtgg caccggccgg
     9241 gctgcgcagt acggtcttcc ccacgaacgc ggccattccg gctccgtacg cgcacggcta
     9301 cacgaaccag acggcctcgg gcaaggtaga ggactcgacg cactggaacc cctcctgggc
     9361 ctgggccgcc ggggcgatga tctccgacct ccaggacctg cgcagttggg cccgcaccct
     9421 cgccgtcggc acgctgctga agcccgccac ccaggccgag cgcctgaaga ccacgccgat
     9481 ggacattccg ggtgccggct acgggctggg catcttcgac gtccagggct ggatcggcca
     9541 caacggttcg atccccgggt acgaggtgct gcccgtccac ctgccggcgg cggacgcgac
     9601 gatggtgatc ctcctcaaca ccgacagcca gtacaagggc caggagccga gcacgctgtt
     9661 cggcgaggcg gtcaccggca tcgtgacacc cgatcacgtg taccccggcc acaagccggt
     9721 cgtgcccagg accggttgac gaccgcggcc cttctccctg cggaatgggc gcacgcaatt
     9781 ccggtcggcc gaccgatcgc aggaaggcgc ccttttccgg gaaacaggcg acaaaacgcg
     9841 gccgtccgcc cccgtccggg gctcgatcgg cctccccaaa agatgccccg gtcaaccgtg
     9901 ttgtccgaca ggtgagttat tacacagaag acatggaagg tcgcacacag ttcgggtaac
     9961 tttccatcac gtcgccgcca cacccggggc acagggcccc atgggacttg cggcgcaaag
    10021 gacccgaccc ctgttgacga cagcaaccga agtcttcaca gtccggccgt acacccctca
    10081 ttgccaggtg atcagcaccg aaggcgatca tgccgtgata ggaatttccc cggggaacag
    10141 ctacttctcg gcccaacgtg tcattgacct cgcccattgg ggcatgcgca acttcgagca
    10201 ggtcgacctc atctacaccg acctgcacgt ggccgagatg tacgaggccc tcggatacgg
    10261 cgaggacgaa gcccgacgca aggcggtgaa gaacctgcgc ggtgtccgcg ccaaggtcaa
    10321 caacgccgcg gccgaagccg accccaccgg cgcccgcctc cgcgcccgcc cgatgtcgtc
    10381 cctcaccgac atcccggcgt accgcacgct ccacaaccac ttgaccaacc tgctcgacat
    10441 cgacccggag ttccgcgaga cctgcaactc cctggtcgac gtgttccttt cgtccaaggt
    10501 gctgggcggc gaggcagcca ccacccggca gcgcgacgtc tgcctggagt acgtctgcgc
    10561 cgaagccccg ctcttcctcg acacgccggc catcctcggc gtgccgtcct ccctcaactg
    10621 ctaccaccag ctcctgccca tggcggaact gctctactca cgcggctcgg gtctgcgcgc
    10681 ctcgcgcaac cagggccacg cgatcatcac ccccgccgaa ggagtacccg atgtccactg
    10741 acacccttct cgacttcccg ttctccgcgc gcggcgacca gctcccgccc gagatcgagg
    10801 agctgcgcag cgagccggtg aagcgggtcc gcacgatagc cggggacgaa gcctggctcg
    10861 tctcctccta tccgctggcc aagcaggtgc tcgaggatcc ccggttcagc ctgaaggaca
    10921 cctcggcacc cggcgtgccc cgccagtacg cgctgacgat cccgcccgag gtcgtcaaca
    10981 acatgggcaa catcaccggc gcgggactgc gcaaggccgt cctgaaggcg atcaacccca
    11041 agaccgacgg cctcaccgac tggatgcgcg cccaggcgac gaccctggtc gacaacctgc
    11101 tgagccacgg ggcgccggtc gatctgcgcg gcctgttcac caacccgtac gccgagaacc
    11161 tgcactgccg catcctcggc attcccgagg ccgacgcgcc gcgcctggcc gccagcctcg
    11221 acatcgcgtt catgaactcg gcgtgccccg tcaccggcgc caagctcaac tgggaccggg
    11281 acatcgccta catggtggaa cgcctcgacg acccgaccac caccggtctc atcgccgagc
    11341 tcgccgccct gcgcaacgac cccgcctacg accacctgac ggacgagatg ctcgccaccg
    11401 tgggcgtcac gctgttcggc gcgggagtca tctccaccat gggcttcctg accatggcga
    11461 tcgtctcgct cctccagcac ccggagatgt gggagcggct gcgcaaggag ccggagaaga
    11521 tcccggccgc ggtggacgaa ctcctgcgca tcaacctgtc gatcgccgac ggcctgcccc
    11581 gactcgccct ggaggacctc accctcggcg acgtcgaggt gaagaagggc gagctcatgc
    11641 tcgtcctggt cgaggccgcc aacaccgacc cggatgtgta ccccgacccg cacgtcgcgg
    11701 acatcgaccg gccgaacgcc ggcacgcacc tgtccttcgg cggcgggcag cactactgcc
    11761 cggcgaccgc cctcggcaag cggcacaccg agatcgccat cgaggtgctg ctggagaaga
    11821 tgcccaacct cgcgctcgcc gtgccggtcg accagctggt gtggcgcacc cgcttcatga
    11881 agcgcctgcc ggagcgcctg cccgttctct ggtgatcggg tcggcgcgcg ggagcgcgcc
    11941 cgtccgatga cggccccggc cggggggaat ccggccgggg ccgtcgccct gccccgaccg
    12001 ttccggtccc gtacgcaagt cccgtaccgc aagtcccgtt gccgcaagtc ccgtacgtcg
    12061 gcttcgtacg ggtggctacg ccaggaacgc cgcggtgctc gccacgaacc gctccgcgtc
    12121 gtcgagccag gggtagtgcc ccgcaccccg ctgcacgacg aacgtggcgc cggggaacag
    12181 cgcggcggac tcggcaaccg accggggcgg gctgttcacg tcgaactccc ccgcgagcag
    12241 caggacggcc gtccggcacc cggcgagcgc ggcgcgcgtg gcctgcgggt cgaaggcgcc
    12301 ctcggcggcg aagagggtga cggcctccgt gttgtccggc cgggacgccg cctggtgccg
    12361 ccgtgccgcg gcgtcccacc ggccgtggaa gaaggggctg acggcctccc agtcgctgcc
    12421 ggtgccctcg gtgatcgcct ccagcgcggc gaacgccgcc gggtaccacg gctcgtccct
    12481 cctgagtcgc gcgacctcgc gccgggcctc cgcgctgatg gtgaggccga cggcccgggt
    12541 gcccggggtg atcagggcga gtctgcggac gcggtccggg taccgggcca ggtactgcgt
    12601 cgcggggttg gcgccggccg agtgggcgag cagatcggtc cgggcgaggc cgaggtgtgc
    12661 gcggagggcc tcgatgtcct cgacgaggcg gtcgcagcgg tagctggagg tgtccgccgg
    12721 gaccgcggac cggccggtgc cgcggaggtc cggaacgatc agccggcggt gcgcggacag
    12781 accgcccagg tcgccgaggt aggaggagtc cgcgggacct cccgggacgc agagcagcgg
    12841 gtcgccgtcc ccgtggatgc ggtaggccag ccgggttccg tcaggtgcgg tgaaagtggg
    12901 catgccgcgg atcctgacag ccataacctg gttgtacaac caggttataa gtaaggggcg
    12961 gctcggggta taaccgaggc atgacagaac cggagagtga gagtgcgcac cggcagtccg
    13021 ggacgtccgc cacggacggg actcccgcga cgctgaccga ggaacaggcc gtacggatgc
    13081 tcgcaggcat gaacgaggtc atccgcgcgg gcgaggagat gcgcaggctg cgcgccgaga
    13141 tgatcaagct gttcgccggg ttcggctgga cccaggaccg gatcgcgcgg atcgccgaca
    13201 tgagccagcc cgccgtgtcc aagcaggtgg cgaagtacgc ggtcgacgcc cccgcgcgcc
    13261 cgatgactct cgccctcggc cagtacgacg gcccgtggct cgaagggcgg ctgtgggggc
    13321 tcgcggaggt ggtcgccgag acgatcgacg gcgcgcgctg cgcccgttac gtcgatgccc
    13381 tggcccgggg ccggaagcgc ttcacgcccc ggaacgtgga tgagctgcgg cgcctgctcg
    13441 aagaggacct gaggctccgc cgggcggagc tgtccgacga cttccgggct gcgtacgacg
    13501 agatcggccg cggcctcgac gaccccccga agggtccggc cggtacgacg tcaccggtat
    13561 cggcaccggt atcggcctcg gcctcggtcc gccgcaccct cgcccaccag ctgcaacgcg
    13621 accggctgga ggccggccgg ccgccgggcg ggagctgacc cccgcctggg agcaagctct
    13681 caggagcggt tgctcccatc ccttgcgcct tcctccgcgg ccaccgcggg accgatgctt
    13741 ccggcgtgcc ccttcctcct tccgaaaggc atgtcatgaa agctcgaatc ctcgccgcct
    13801 cgttgagcgc cggcgccctg ctggccaccg ggctgctggc cgcgcccacc gcgtcggccg
    13861 ccgcggctgc tccgagttgc gtcggatcgg cgtgcaacgg caagaacccg gccggcacca
    13921 gctgccagaa cgacgcccgt acggtcgccg agtccggcga cccgatgggc gccatggagc
    13981 tgcgctacag cccgtcctgc cgagccgcgt ggggacgatt caagatcaac gcaccgtccg
    14041 gatcgcgcat agagatcaag aacaaccagg gcaagaagta cacgaccagc ggcaccggca
    14101 agttctacag cgtcatgatc aacgacaagg acgtgaaggc ctgggcctgc ggcatctggc
    14161 cctccgagtt cggtggcacc aacaccgcct gcaccgagga ctactgatgg gccgccgagc
    14221 agcgaagacc acccggaccg acccgctcgg cggcgcccgg cgcaggctcc tcgtcaccgg
    14281 cgccgcgctc gtcggcacgc tcgccctggc gaccggcccg gccctggcca ccacggcgaa
    14341 cgtcgggggc caggtcggcg gcagctccac gtactacggc accgcccgca ccgtcaccgc
    14401 cgacggctcg cacatctgcc tgagggccga cagcggcggc atcgccatga aggccttctg
    14461 gtacaagtgc agcgaccgca gcacccgggg cgcggaccgg gaggtcggtt cggggacgcg
    14521 ccagcgcctg ggctccggct tcaaggccgg tacggtctac tgcctcggag cagcggcgga
    14581 cgtcgtcagc ccgaacaaga cctcctggag cggaaccctc gactggaacg tcttctcctg
    14641 agtccggggc cgtacgggga tgccccgtcc cggcgacgag cgtcaacggg ccggggcggc
    14701 gaccccgttc ccgcccgcta caaccaggcc gcctgcgcgg cccgcagacc ggcctcgaag
    14761 cggctgcggg caccgagcct ttccatgatc gatgccatgc tgcggcggac ggtgctcagg
    14821 gacaccccga gtcgccccgc ggccgtctcg tcggtgagcc ccttggccag cagggtgagc
    14881 aattcgcgct cctgcgcggt caggccggtg ccctcgtgcc ggggctgctg tgcgccgagc
    14941 ggcaggccca ccgcccatac ctgctcgaag agcctcgaca gcgcggtcat cgccccggcc
    15001 gtgtggagga gtacggcgcc gcgccgggtg tccgagggat cgagcgggac cagggcgctg
    15061 gtgccgtcga tgaggatcat ccgcagcggc agggtgggga ccgtacgcac ctcgccgccg
    15121 ttctcggtca gccagcgggc gtacgcgagg gtgggggcgc tgttgcggac actgtccagg
    15181 cagaccgttc ggacctccac accgcgcagc aggatctgcg cgtcgttgtg ccgggccgcc
    15241 tcgatcgatg ccggggagtg cccgccgccc ggcatgaacg tacagaccga gtcggtcgcc
    15301 ttgttggcga cctgctccag ccggctccgg atggcatcca tgccgatcag gcgctcgctg
    15361 tcgggttcgg cgccaccgac ggcgggcccg gcgcagtctg cgatcatgcg ggtgaccgcc
    15421 acgtgcgtgt cgtccagttc gcgccggcgc cgttcgagct cctcctgccg gcggcgcagc
    15481 agcagctgca acccgagttc ggggtggatc gcccgccagc ctccgggccg atccgccgac
    15541 ctgcggagca gcgcgagttc ggcgagtctg tccagcgcgt cccgcacctg ctgttcctcg
    15601 agccccagct gctcggccat ctgccccacg ccccagccct cgggccgcgt ggccagcaac
    15661 cggtagacgg cctcggtcgg tgtgtcgagt cccagtgcgg acagcatccc ggcgttctcc
    15721 tcccccacgt cgacgacttc tcttccaggc gcagcagcat ggggggaggc agggccggag
    15781 gtcttgtagg aatcggagaa ccggagttca gtccgtggcc gtgtccggca gcagcaggct
    15841 cgtgacccgg cccgccaccc ggtccagagg tgagccgggg cgcagtccgc cccggcgggc
    15901 cgcgaactgc gagggtgtga gccccgtcat cgccttgaac tcacggatgc agtgggcctg
    15961 gtcgtggaat ccgccggagg cggccacggc cgccccgtcc aggccgaggg cctggaggcg
    16021 cagcgcacgc tggagtctgg ccacccgggc gacggccttc ggcgccagcc ccacctgctg
    16081 cccgaaacag gcccgcaggt gccggtcgct ccagccgacc tgccgggaga tggcggtgag
    16141 ggcctccggc cggccgtcgg caccccgccg gaattcgacg agaagggcac tccagcatga
    16201 agtcgcgcgt gaagtcaccc gtgaagtcat tcgccgccct cggcgtgttc gtcgtgggcc
    16261 tgtccgcgct gctctcgggg tgcgccgacg ggccacggtc cgccgccgcg acggaactgc
    16321 tggaccggca ggggtacgac gccgtgctgc ggcggagttc cctcagctac cgctggcccg
    16381 ccgactaccg gcccgacctc gaccggctct ccgcggacag cgcgccgggc ggcggcgagg
    16441 cggcgctcgc cgggagcgaa aggatcattc tcgaaatcgc caactcatgt gcctggtacc
    16501 gctcctggga cgatgcacga ggccgtgcgg accatgcccg ggccgaggag gcgctcacgg
    16561 ttctggaaga ggtgctgccc ggctacggac cccagaaccc ggacggccgg cggtacgccc
    16621 gtgaggccgc ctccagggcc cgggccggtg acccctccct ggcccggcag ttcaccgagg
    16681 ccaactgcga cggtgtgatc gcctgggacc ggacgggcat cgacgccgag ggctgagccc
    16741 ggcggcaggt acgggaggac caccatgacc acgatgacca cgaccggtgc cggtgcaggt
    16801 gcaggtgccg gtgccggtac tgcttcgccg gtcggtgccg gtgcgggcgg gcgcaccccg
    16861 ccggtgctgc gcctctacca cgagctgttg gcggatcggg agcggctgat cgaggcgcac
    16921 caccggctgc tggccgagca gaacgccctg ctggaacaga tcgacctgct gtgcgcacgg
    16981 tcgacggcgg ccggatccga caccccgtgc ggcagtccgc ctccgctgtc cccggtccag
    17041 cggcaggtac tggtgctgat ggccggcggg gcgaaggacg gggcgatcgc ccgccggctg
    17101 aacctcagcg agcgctccgt gcgccgccag gtggagtccc tgacccggcg aaccggagcg
    17161 agcaaccggt tcaccctggc tctcgccgcc atcaggatcg gctggctgcc cgccggccgc
    17221 tgaacccgtc cgcggtccgg aaccggcgcc tgtcctgcac cggacagatg tcctgttcgg
    17281 cctgggcagg accgactccg gctgctggac tgtgtgttgc cagcacaccg atccggacaa
    17341 ggggaagatc ctcatgcgca gccgagtccg cagcaccctc gccaccagcc tcgtcggcac
    17401 caccgcggcc ctcgtcgccc tgctcgtgcc cggcaccgcc cacgccgccc cggcgaagct
    17461 cagccactcc tccgccgtga gcaagctgaa cgcgacgggc ggcatcggcc tgtcctccag
    17521 cggcggttgc agcaaccgca acaacagcac ctgcacctca ctggaacagg tcaacgccgc
    17581 gagcatcagc gatgtcatca ccctgcgcaa ggcgagcaac tgcaccctca cgatcacggg
    17641 cgggaccgaa gtggggcacg cctcgggcac ctacagccac tggaacggct acaagatcga
    17701 cttcagcccg accagctgcg tcagcaacta cgtcaccagc agcttcaccc ggatcgccaa
    17761 ccgcggtgac ggcgcagccc gttaccggtc cgccgccgga aacgtctacg cccgggaaag
    17821 caaccactgg gacgtcacct tctgcggggg cagctcggcc tgcacgtccg cggccagttc
    17881 ctgagcggtc cccggccggc cggcgggggc gccgccatca tcacgccccc gccgagccgc
    17941 tccgagcggc ccggtcagtc ctcttccagc accgccctga tcacgtgccg ggcgttgtcc
    18001 gccatcgccg ggttcgtcgt gcggtagtag ggcagggcga tcaccgcctg cgagagcgtc
    18061 cgcccccggc cgcggcgcca ggtcgcgtcg tccacaccga gcgcctcgcg gaagacggtc
    18121 ctcgcgccgg ccggcagcgg gttccacgcc gggaacagat cgcaggccgg atcacccacc
    18181 cccatgcacc cgaagtcgat gaccgagctc agtctgcccc cgctgatcag caggttgccc
    18241 ggcatcagat cggcgtgcaa ccacaccggc ggcccgtccg gcgcgggcgc gcgcagcgcg
    18301 tcctcccaca cggcggtcac cgcatcgcag tcgacgccct cctgcgggat cccccgcagt
    18361 tgcccgatcg ccgcccgggt cgctgcgtcc agcgaggccg gcggcccgcc ccggtgggcc
    18421 cgcggcgccc ccggcagggt gacgctccgc atcgccgcca cgaacccggc caggtctgcg
    18481 gccagcgcct cgggctcggt cagcccaccg gcccgcgggt tctcccccgg cagccaccgg
    18541 tacaccgacc acgcccacgg atacccgtgc gcgggttccc cggccccgag cacctcgggg
    18601 acggccgtgg gcagccgggg cgcgagtcgg ggcagccact cctgctccat ggacacgtcc
    18661 gcggccccgc ccgcgagcat cggcagccgt acgaccatgg tgtcgcccag ccggtacatg
    18721 acgttgaccg tgccgccgga cgggatccgc tccacggccg acgcggccca ctgggggaac
    18781 tgcccggcga tcagacggcg taccaagtgc tcgtcgacgg ggtgcgcgcc ggggtgcatc
    18841 tgtgcggtgc tcatcgaccg ccatccgacc gccgaaggcc cgccgggtca aacccttttc
    18901 cctccgcccc gtgcggtgcc gttgcccgac cggggtcttg atcgttcggc tcactgacgg
    18961 gacatacggg ggcagtcggc aacggacggg gcaagtgatc gggatgcggg tcgcacgaag
    19021 gactgttctg caggcggctt cggtgggagc cctgacggcg ctgctcggcc gcacgtccgc
    19081 gacggccggg gcgactgcgg cgacgtcggc caccgtcgcg ggggcgccgg gtgccgccgc
    19141 ggacctggta cggctgcgct tcacccgggc caccaacggg gcggccaccg ccgtcgggga
    19201 ccgggtcgtc gccgaggtgc agggcgtgct gtgggcgctg cccccggacg gcgcgcccgc
    19261 gaagccgctc accccgcccg acctcgaacc cggccgcccg gtgctctccc ccgacggcct
    19321 ccgggtggcg atgagcgcct accgcggggg cgccttccac atctgggtga tgaacgcgga
    19381 cggctcgggc ctgcgcccgc tcaccgacag ccccttcgac caccgcgcgc ccgcctggtc
    19441 gcccgacggc cgcagcatcg ccttcagttc cgaacgcggt ggtgatccgg tcaccggaag
    19501 tccgtaccgg atctggaccg tcaccgtcac gggcggcagc ccgcgccggc tgacgggcct
    19561 gcccgggcag gacgggccgg gtcaggacgg ggaatgggag gacttcgacc cggtctggtc
    19621 gccggacggc tcgcgcgtgc tgttcgtacg cggcacgccc accggggaca ccctgaccgc
    19681 ccggaccatc gcctccgtcg ccgccgggcc ggacgccgac gggccggtgc ggatcgagca
    19741 caccgtcacc ggcggcaggc tgctgagccc ggccctctcc ccgtccggac ggaccgcctg
    19801 gctgtccgcc gcccccggcc cccgcaaggc cgagcacctc tccctgtacg tcgacggccg
    19861 accggtcccc ctcgacggag atctcgcgcc ggctcccccg cgctggatcg gcgacgatcg
    19921 gctgctgatc accctcgacg gtcggttccg gacggtccgc ccgcaccggg aaggcgccga
    19981 cggcagcggc gacggccggg acggcggcgg ccgcgatatc ggcgagatgc gcgagatccc
    20041 cctgaacgcc accctcgaag tgccccgccc gcgctaccgg gtcaaggagt acgtgctgga
    20101 ggccgaacga agccttccgg tccggggcat ccacctgccg gccctctccc ccgacggccg
    20161 caacgtcgcc ttcgccgcgc tgaacgcgtt gtgggtcgcc cccgtcaccg gcggtgcgcc
    20221 ccgccggatc gtccgggccc ccgaaacggc gtacgtccag gggcccgtat ggaccccgga
    20281 cggccgcgcc ctcctctaca ccgacgaccg cgacggactg aacaccgtgc gacgccggga
    20341 actcgacaac ggccgcgaga gcgtcctcgc cccgggcggc cgtgtctacg gggtgctgtc
    20401 accggacggc aggcgactcg cggcgctcga cctcgccggc cggctcctcg tgcgcgacct
    20461 cgcgaccggt accgagaccg cgctcgtcgc ggcccgcggc ggcggcggtc tgcccggccc
    20521 gcccagctgg tcgcccgacg gccgccacct cgccctgtgc gaccgcaacc ggctcagccg
    20581 gcgcttccgc gagggctaca acgtgatccg gatcgtcgac accaccaccg gcgccgcccg
    20641 gctccacgcg ctcgccccgc acgcctcgct cgccgaccgc tatgcctccg ggccggtctg
    20701 gtccccggac ggccgcttcc tggcctgcgt cagcgagtcg g
//
