LOCUS       NZ_BMVE01000019        26375 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence19, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000019
VERSION     NZ_BMVE01000019.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 122719)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 96344
            Orig. end                         :: 122719
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26375
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="terpene"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..26375
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21104
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21104
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:11104](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11104)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(704..2695)
                     /locus_tag="IE248_RS34450"
                     /old_locus_tag="GCM10010336_70350"
     CDS             complement(704..2695)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS34450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_70350"
                     /product="ATP-binding protein"
                     /protein_id="WP_199848683.1"
                     /transl_table=11
                     /translation="MGERLSRARVRAFVGRDEELGRFGAALAGDPRAPFAFYAYGPGGI
                     GKSTLLRRLADHARAAGRLLVELDGRFVSRDPVDFEQAAGPFLDVPGTVLFVDSFEHCQ
                     WLESWLWHHFLPRAADDTLVVLAGRRAPQPQWTADPAWARLLHVSELEPFSEEQARSLL
                     VAAEIRPELRDRVLRFAGGNPLALSLAAAAGSEGCGRQEIWAPTADVLRTLLAGLIGEV
                     PTAAHRRALEVASQAHSTSEELLAAVLPGEDAHQLFSWLRDLPFIESTHRGLHPHDAAR
                     ETLAADLRWRAPNAFEAMRRRLADEYLRLLREAPEERVWTVTDELFYLFREGATLSRLR
                     SWSREDEVHDRPLQPADIDVVLRMTEETEGAASAELVRYWARRQPQAFSVYRLVSTGRI
                     VAFTARLVLPAPADPQDLATDPVVAAAWRYTDATAPVSPGEHIGVSRFSVYPERYQVPS
                     RVIDLSSSRAQAEAARARGRAYGFAVYQDAETWAGRVRGTLHDTGARPRVGEHTYGVFG
                     VDWREVPVEAWLQRFISATEVTVPPPGPSPVSRTAFDQAVREALAHWRDADAFAACALM
                     RSRLAADFEDPAGELRALLRGAVDDLARDPRGVRAREALTAGHFSGAPTQEAAARRLGL
                     PYGTYRRHLRQGLDMLCEALWQRELRPR"
     misc_feature    complement(2759..2777)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.53"
                     /tool="antismash"
     gene            complement(2828..4048)
                     /locus_tag="IE248_RS34455"
                     /old_locus_tag="GCM10010336_70360"
     CDS             complement(2828..4048)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0046148 - pigment biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735535.1"
                     /locus_tag="IE248_RS34455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70360"
                     /product="cytochrome P450, cyclodipeptide
                     synthase-associated"
                     /protein_id="WP_190032772.1"
                     /sec_met_domain="p450 (E-value: 4.4e-34, bitscore: 110.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQVTPRFSVLSEDFSADPYRHFAQLRERAPVHYEPAIDSYFLSR
                     HEDVKRVLTDHEAFTTETLQVRAEPVMRGPVLAQMTGAEHTAKRGIVVRAFTGQALQDQ
                     IRAIHANAEEIMAPFLARGRMDLVNDFGKPFAVNVTLDVLGLDRRDARRVAAWHSGVAE
                     FITSLDLTPERRRHCLECAEQLEAYLLPVIEDRRRHPGEDLISKLCTAEFDGIAMSNRD
                     VTALIINVLAAATEPADKTLGLLFKHLIDHPGQLAEVREDPELLTAAIAETLRYTPPVQ
                     LIPRQAEEDTVFAGATVPAGATVFCVIGAANRDPAAFGAPDAFDIHRPDLGTARSFTAA
                     AQHLSFGSGLHQCVGAAFARAEIETVAAMLLPRLDRVRFSPGFRYREAGLYTRGPVSLS
                     LDFTPVR"
     misc_feature    complement(4100..4117)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(4247..5155)
                     /gene="puuE"
                     /locus_tag="IE248_RS34460"
                     /old_locus_tag="GCM10010336_70370"
     CDS             complement(4247..5155)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="puuE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735533.1"
                     /locus_tag="IE248_RS34460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70370"
                     /product="allantoinase PuuE"
                     /protein_id="WP_190032773.1"
                     /transl_table=11
                     /translation="MSEHQRDLVGYGAEPPHAAWPGGARVAVSLVLNYEEGGEQNVLEG
                     DPASEGFLHELVGAPPVVGGRDLNVESMFAYGSRAGFWRVHRTLLAHGAPLTVYAVARA
                     LERNPDAARAMGAAGWEVASHGRRWIDYRHVPQDTEREDIAYSIATIERLVGRRPVGWY
                     TGRTSPHTRRLVAAEGGFLYDSDDYSDDLPFYVESAGRPHLVVPYSLDANDCKFLLVHG
                     FTTADDMLAYLIDTFDALHAEGGDRPRMMSVGLHCRIIGRPGRIRALDGFLKHVARRGG
                     AWIATREQIARHWLATHPPRG"
     cand_cluster    4454..26375
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4454..26375
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[14453:17066](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14454..17066
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
     misc_feature    5283..5298
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.59"
                     /tool="antismash"
     misc_feature    complement(5287..5301)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.2"
                     /tool="antismash"
     misc_feature    complement(5343..5356)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.81"
                     /tool="antismash"
     gene            5523..7151
                     /locus_tag="IE248_RS34465"
                     /old_locus_tag="GCM10010336_70380"
     CDS             5523..7151
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735531.1"
                     /locus_tag="IE248_RS34465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70380"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_190032774.1"
                     /transl_table=11
                     /translation="MAQENIPPEVRRPEAPAHWPLLVIAAVTAACVAGTLFSSSEPVVF
                     VWTALGASCTAAALVEAMRRGRAAADGRARVAELRHALSRQEDEAVRLSEVVLTEAIAR
                     LRKGELPEEVLNSVAGRAGRSARWGSDGALTPRFRTALRTVLARVVDAVDNEESLRDSA
                     QRAFVNIARRVQAIVHQQAHEMREMEERHGRNPDVFGDLLRLDHGTALVGRLADSISVL
                     GGARPGRQWSRAVTLYSVMRGAMSRIIDYQRVELHSVSEVAVVGPVVEPLIHALAELLD
                     NATRYSPPHTRVHLTAVEVQSGIAVEIEDGGLSMSDEARRRAERLLAQAQSGIDLNDLG
                     ETPRLGLAVVGRLAQAYGFQVSLRSSAYGGVRAVVIVPQHLITTASAATGLAHGIGSSS
                     GPRVVSPTAREHPADHMASGAPGAFGAPASARPSTWPGTPVSRPAAPPVAGPMPTPMPT
                     TMPTPLPEPTVTGEGTPVTSRTATGLPQRRRKDRAITSDVSPATAPLPTADAGPGMWLE
                     AFHSGLSGAPGQDGEGVSGSATEGA"
     gene            7180..7566
                     /locus_tag="IE248_RS34470"
                     /old_locus_tag="GCM10010336_70390"
     CDS             7180..7566
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735529.1"
                     /locus_tag="IE248_RS34470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70390"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_174261790.1"
                     /transl_table=11
                     /translation="MDWMLKDLAVGVPQTRHVIVLSADGLCVAQYGAETDTADRLAAAC
                     AGLQSLAGAVAAELPHSKGRMRLVVIEMDGGFFYLMAAGDGSYLAVLADEGVDAGLMGA
                     QMRNLVTRLGDHLSTPPRHDGQPE"
     gene            7563..7922
                     /locus_tag="IE248_RS34475"
                     /old_locus_tag="GCM10010336_70400"
     CDS             7563..7922
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735527.1"
                     /locus_tag="IE248_RS34475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70400"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_008735527.1"
                     /transl_table=11
                     /translation="MTEPPGSWEDGGPERLYVITGGRSEPSIATRLDLVSLVVARAAVR
                     PEMQPEQAAILRMCQAPLAVAEIAAHAGLPVSAVIVLVADLLAAQHVHVRPPVPAAQLP
                     DLALIEAVIDGLQRL"
     gene            7903..8523
                     /locus_tag="IE248_RS34480"
                     /old_locus_tag="GCM10010336_70410"
     CDS             7903..8523
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944873.1"
                     /locus_tag="IE248_RS34480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70410"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_190032775.1"
                     /transl_table=11
                     /translation="MDFRDSDAPAGPRGADVLPQTAAAAVKVVVVGGFGVGKTTMVGAV
                     SEIKPLTTEETMTRAGIGVDDTRGVTRKTTTTVAMDFGRISINDELVLYLFGTPGQERF
                     WFLWRGLFEGALGAIVLLDTRRLEISFDVIGRLEERGVPFVVAVNSFPGAPEHPVEELR
                     EALDLPPAVPILVCDARRRDSSRDVLLTLMRYLYSQAATQEAM"
     gene            8520..9941
                     /locus_tag="IE248_RS34485"
                     /old_locus_tag="GCM10010336_70420"
     CDS             8520..9941
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735524.1"
                     /locus_tag="IE248_RS34485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70420"
                     /product="cytochrome P450"
                     /protein_id="WP_229895736.1"
                     /transl_table=11
                     /translation="MSTRPTPPPECPAHAPGAAGGLHRLHGPEAEADPMGLYEKLRAEY
                     GPVAPVLVSGDLPAWLVLGHRENLDVARTPSRFARDPRGWRDMREGRVPADTPLGPMVT
                     WVPVCNFTDGPVQERLRGAVVESLERFDKRGIRRYVTRFANQLVDRIAGDGHADLVAAF
                     SDQLPMLVMTQLVGAPDEHGPLLVNAARDMLQGTETALQSDRYVTVTLEQLVADRKAQP
                     ARDLASWLLEHPANLSDTEVLMHLRVVLIAAYETTANLIANTLRTVLTDQRFRASLSGG
                     HMTLPDALEQVLWDEPPINTIIGRWATGDTVLGGRQVKAGDMVLLGLAAGNADPQIRPD
                     ANASVRGNRSHLAFSSGPHECPGQDIGRAIADTGIEVLLDRLPDVRLAIDASELRWHGT
                     LMSRHLLSLPVRFAPRPVKDAQPQPHPYQEQPAAHPPVPSALPAPLVPPQPAVAPAPAG
                     HRRKGGWWHRLLGRR"
     gene            complement(10001..11104)
                     /locus_tag="IE248_RS34490"
                     /old_locus_tag="GCM10010336_70430"
     CDS             complement(10001..11104)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744115.1"
                     /locus_tag="IE248_RS34490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70430"
                     /product="terpene synthase family protein"
                     /protein_id="WP_229895737.1"
                     /sec_met_domain="T1TS (E-value: 2.2e-65, bitscore: 214.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATAHRPRPSRLGPRLPAFYCPLPQGLVHPEAKQVEARAVEWLDA
                     FGLYRDPVERAWGLATHSADFSCRLIPEGDVEALLLFTEWNYWANAIDDWQDSGAAEVR
                     TAAVVDHGARLVRTLQDPGAALLPDSAVTRALADLVRRTHALLTPFQLRRFVEGTRDWL
                     LGAAWQAAGAESGVMPTLNDFAALGSLANGTRFSLTWSDVARDIRLPADVLYSPALEAL
                     TDAAGFVVSADNDLFSYDKDDHLVPREVNLINVIAHQENCPPAGAVPAAVALRDRVMVL
                     FLALRAQLAAGADAPLRRRLEALEHYVAGCITWQSRAPRYASPRNRHHLPLEHARFAVR
                     YSDLPADPGTGPPDLPALASWWTHLRS"
     gene            complement(11104..11952)
                     /locus_tag="IE248_RS34495"
                     /old_locus_tag="GCM10010336_70440"
     CDS             complement(11104..11952)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (68-166). E-value: 1.1e-13. Score:
                     42.0. Matches aSDomain: nrpspksdomains_IE248_RS34495_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954317.1"
                     /locus_tag="IE248_RS34495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70440"
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     family protein"
                     /protein_id="WP_190032777.1"
                     /transl_table=11
                     /translation="MRLYYSRKTGDILQKYGPGPRVHFHVGLFTADATPHVTVSQRTLG
                     RRLVDAQERIVEHAARSWKAYEAPPGRVLDIGCGLGGAALYWAQEHGASVTGLTVAAEH
                     VPIIQGFARRAGVEDKVDAVPGNVHDLDATRVYDAAYANESSGYTDRARLFEVVAKALK
                     PGGWFGIQEHFVCRPEWRDFVDGYYRTRLGTRTEYLAAAEAAGFGLERDEDVTDAVAEF
                     WLQSMAWNTAELDRLRAGGRGGSWSRERLGESTIAHSKLFRLWRDHALETRLLLFRLGG
                     S"
     aSDomain        complement(11455..11748)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS34495_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.10E-13"
                     /label="IE248_RS34495_oMT.1"
                     /locus_tag="IE248_RS34495"
                     /protein_end="166"
                     /protein_start="68"
                     /score="42.0"
                     /tool="antismash"
                     /translation="PPGRVLDIGCGLGGAALYWAQEHGASVTGLTVAAEHVPIIQGFAR
                     RAGVEDKVDAVPGNVHDLDATRVYDAAYANESSGYTDRARLFEVVAKALKPGG"
     misc_feature    12175..12187
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     misc_feature    12176..12185
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.41"
                     /tool="antismash"
     misc_feature    complement(12200..12213)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.03"
                     /tool="antismash"
     gene            complement(12246..13712)
                     /locus_tag="IE248_RS34500"
                     /old_locus_tag="GCM10010336_70450"
     CDS             complement(12246..13712)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003592.1"
                     /locus_tag="IE248_RS34500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70450"
                     /product="APC family permease"
                     /protein_id="WP_190032778.1"
                     /transl_table=11
                     /translation="MTQAPTEGPDSESAVEAGGYRQELKRTLGSFQVFAISFAFISVAV
                     GIFATFDEVLVTAGPVGIWLWLVAAVGQSLVALVVAQFAARIPLSGSSYQWASRLGDPK
                     VGWWFGWLTFCYLAIAVVAIDNALASQAFMPLAGIAADEDTARVITLVVLLVQAVLAIA
                     STRLVGWINSAAVGLELALVVVVAIALVIVVAVTGNGSTANLTSRGITEHAPGYFAVGG
                     GLMLAMIMGLATLVGFDSAANLAEEAKDPYRSVPRAIVGSVVAAGVLGMLFLITLTLAI
                     EDVPRISHEASPVAAIMRDRFGAVAERTLLVAITFAFFGAGIVVMTACSRLVYAMSRDS
                     RFPAHRTMRRVSPRTRTPVPATLLVLGIGVVLMIALPGAALLELITASTILPALIYGAT
                     IVLYLTVRRHLARQKGAFDLGRLELPVAVCALAWTLIALFVLVTPAEALTAVVIVGGLL
                     LLGGLFFLGMLTFDREVLESEPGDESAFRH"
     misc_feature    13722..13737
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    13831..13845
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     misc_feature    14261..14274
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            14454..17066
                     /gene="lanKC"
                     /locus_tag="IE248_RS34505"
                     /old_locus_tag="GCM10010336_70460"
     CDS             14454..17066
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007495251.1"
                     /locus_tag="IE248_RS34505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70460"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_190032779.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1020.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 2.8e-10, bitscore: 33.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.8e-09, bitscore:
                     29.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNQYEAYTFADPLFYESPRRWGAQEEFEAATRPLPAGWERGDLE
                     MWSVVRPAGVVLPDQGWKIHVSSCAADAEAVLEALHAYCLSERITFKFLRGLPILQVQN
                     SKYAPRGSSGKFCTVYPVDDAELERCLDGLGTLLAGRRGPYILSDARWEQGPLYLRYGG
                     FVERHCRDAAGERVLALAGPDGALVPDVRGAGFSVPDWAPVPDCIAPAVAARRATRGPD
                     LPYTVERVLHFSNAGGVYLARRAEGDPPVVLKEARPYAGLDQRGVDAVTRLRHEHEVLT
                     RLAGIPGVPALPGGDPAVPGEQSLFSVWEHEFLAQEHIDGQSLSQWLTGHYPLIHPDPD
                     PQTVAEYTQEALGLVERIERTLAAIHARGIVFGDLHPRNLIVRPDGEICFIDFELASPA
                     DAFVRPALGAAGFTAPAGYSGSDIDHYGLSAIRLWLFLPLVQLTALDPAKADELADVIE
                     RRFPVPSGYTEPIRRMIAAPPAPAPPATRTARPGIGHGREAAHALLTATPADWPRLRDS
                     LAEGITAMATPDRTDRLFPGDVAQFRHGGLGIAHGAAGVLYALHTTGAEVREEHVRWLV
                     DASRTRITAPGLYFGGHGVAHVLDLLGEREAALALLRSLEAVREESTGPSLATGAPGIS
                     LTLLHFASVTGEARLLDEALALAQGAADTLEKNGRTDGRRPAGLLAGASGAALALIRLY
                     EHTGDGALLERARTLLELDLDRCLTVADGTTQVVDGRRVLPYVETGSAGIGLVLNALLA
                     HLPDSPAVSYEPSIRRAAEPEFIIQPGLFNGRAGLIGYLALTAARADARHTGPGHTAAL
                     LDRHRALLALHQITYQGHLAFPGDQLLRLSADLATGAAGVLLALGTALGGTPFLPWTG"
     misc_feature    17134..17148
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     gene            17141..17278
                     /locus_tag="IE248_RS34510"
                     /old_locus_tag="GCM10010336_70470"
     CDS             17141..17278
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="IE248_RS34510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70470"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_086025341.1"
                     /transl_table=11
                     /translation="MAILDLQTLELPETEAHPIDDTLASTSSLSVLNCGTSTVSTLVCL
                     "
     gene            17464..19251
                     /locus_tag="IE248_RS34515"
                     /old_locus_tag="GCM10010336_70480"
     CDS             17464..19251
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735510.1"
                     /locus_tag="IE248_RS34515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70480"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190032780.1"
                     /transl_table=11
                     /translation="MADQTAGTVRPARGHDTSRTAPATVRLRHELGAEPGRLSAAILFA
                     LVATGATLALPLFVQEVITDLSGSRPPRAHVVMMCAAAVGGAVTQALSGFLLARVGERL
                     ACRVRIRIMEYSLRLPLGVVKAQGTGDLAARVTSDALLLRQVVDIATQLPLAALTVAAT
                     LAVMVWIDWVLTLVTVGALAVLTVLILLILRRMKDNVSGQQVAIGQIAQRFTANLDALT
                     TIKAYRAEALAAGALAADAERLRAVSLEGARLGAMIPAVLSLGNQFAMIAVILTGGARL
                     AAGDLSIAAFTAFLLYLLQTIPYVSTLATGFGRLQAGLAARDRCNELLLLAPETDPAGA
                     ALDPPTPLPDAPSVIFRSVSYTHPGADEAALRGISFSTARTGLTAVVGPSGAGKSTTLS
                     LIDRFIRPSSGSITVLGHDTRHWPLDALRARIAYVDQEFTLLEATARENLQLGRDGRAS
                     DAELAAALDAVGLAEDITRLPQGLDTPLGRESDLSGGQRQRMALARALLSDADIVLLDE
                     PTSQLDGLNEQRFRAVVSDLAATRAVIVVAHRLSTVQEARHVIMMSDGAVLDAGDHPTL
                     LRRCVPYRALVASQSVAAR"
     gene            19346..20632
                     /locus_tag="IE248_RS34520"
                     /old_locus_tag="GCM10010336_70490"
     CDS             19346..20632
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735508.1"
                     /locus_tag="IE248_RS34520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70490"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_190032781.1"
                     /sec_met_domain="DAO (E-value: 9.5e-09, bitscore: 28.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGADAQSPVIVVGAGLAGLTCALDLVRAGLPVRVLEAADEVGGR
                     VRTDRRDGFLLDRGFQVFNTSYPQVKRRIELARLRLRPFTPGVLIHTAEGGRLRFTDPT
                     RRPSDALALLTGKQDRGPGPGPGQGQGPGPLALAALGPLCALDLLAPPRLLKRLPELTT
                     REELARWRVPDRVVDGFLRPFLAGVFLEDDLDTSSRMFHLTWRSMLRGTLTLPADGMGA
                     VPRQLAEDLPPGCVERASPVAALSAAGVTFADGSAAEARAVVVATDAAAARSLVPGLPA
                     VATRTVTTYHHAATRSPLREPTLLLDARRRILNTCVLTEVAPTYSADGRALISTSVLGT
                     DAPGREAALREVLAELYATGTRDWERVGTTTVAGALPAMVPPWPLSRTGRTASGVYVCG
                     DHRATGSVQGAMASGTRTARELLADLRRP"
     gene            complement(20701..21258)
                     /locus_tag="IE248_RS34525"
                     /old_locus_tag="GCM10010336_70500"
     CDS             complement(20701..21258)
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012859.5"
                     /locus_tag="IE248_RS34525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70500"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_190032782.1"
                     /transl_table=11
                     /translation="MRSPRSSAVRAAVVAAAVLSAATVLAAPAQAKPAESPDTAATGAV
                     TMTAYRFQYANVATGKCLDIRGASRYEYGLLQQFNCKEELHQEFWSDTVLGDPSVDLKP
                     AHVSNLCLEPSGLEAGATIVQRVCNYSQGQRWDFGWNGSSATVKNRVSGLCLEDAGMPS
                     GSRREVRQMPCTGAPGQLWSNR"
     gene            21517..22533
                     /locus_tag="IE248_RS34530"
                     /old_locus_tag="GCM10010336_70510"
     CDS             21517..22533
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS34530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_70510"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_190032783.1"
                     /transl_table=11
                     /translation="MLRIHLTPDDLARVRIAPAPDPLAETILSLPVLQSRDRGGAGLDG
                     WRERTRRALLPGMRPVLELAPARPDEYVPEAFLHAVTATLADSLDHTWSLARRQWTADL
                     HATEVLRPDAPDWIRRLHAGEREWSGIVHSAVERYHAVAVAPYWSQLLAAAHADRTRRA
                     LAAADTGTGGLLASLHPEIRWDPPVLSVPCAFDTDLEPAGRGLDLVPTFFWPRPLALLD
                     NAEPERPLVLRYPLARDLATYRSVWAAAAPTGPDGALAALLGTTRARTLQAAAVPAGTA
                     ELARRTGTSPATASHHASVLRAAGLLTTERDGSGVRHALTPMGRALLQDHALPPPSA"
     gene            22724..22927
                     /locus_tag="IE248_RS34535"
                     /old_locus_tag="GCM10010336_70520"
     CDS             22724..22927
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979083.1"
                     /locus_tag="IE248_RS34535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70520"
                     /product="cold-shock protein"
                     /protein_id="WP_037796872.1"
                     /transl_table=11
                     /translation="MASGIVKWFNSEKGFGFIQQDGGGPDVFAHYSNINSTGYRELQEG
                     QAVTFDVTQGQKGPQAENITVA"
     gene            complement(23012..23485)
                     /locus_tag="IE248_RS34540"
                     /old_locus_tag="GCM10010336_70530"
     CDS             complement(23012..23485)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004948591.1"
                     /locus_tag="IE248_RS34540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70530"
                     /product="ricin-type beta-trefoil lectin domain protein"
                     /protein_id="WP_190032784.1"
                     /transl_table=11
                     /translation="MKKTTGLIGLLALACATAVAVPASASAAPAGRGAVALRNVQTGLC
                     LDGDFGGKIYTKGCGSDNPYQHWYLHEGPMGVMLQSSKTGLCITGKGVGNDSVAAVACN
                     SGDVKQWWEQWNVNGNAYTLLNHQNRKALDSDAKGNAYVHQYGDTNPYQHWSM"
     misc_feature    23487..23501
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     gene            complement(23499..24860)
                     /locus_tag="IE248_RS34545"
                     /old_locus_tag="GCM10010336_70540"
     CDS             complement(23499..24860)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS34545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_70540"
                     /product="hypothetical protein"
                     /protein_id="WP_190032785.1"
                     /transl_table=11
                     /translation="MRSSPLPQLTALPSAPSPRRPRRPVAYGAVAVLVAAAAFVAGPQA
                     SARSTGPAPSPAAPAGSPPAGFASWGELAAAQLPLSEAAGAIEGALGDSPAFTSLTVSV
                     EDRSVTLYHKGGEEQVEAAVAPQRAKGVRVELRSAPYNRSELREAAASLMGRSLTIDGQ
                     LTSVHSAGARSDGSGLLVEGEPLRANDTNSGNGRARTAEPPVPWTGTVTGAPAPLESRE
                     QDAPLHSGGMLLRQRYKGGPICTSGFVVTWPQRGLDYLMTAAHCSEAGKTWYAGDQDIK
                     LGPVSDRSERYDTELIPTHGGFLHNYTIWSGQPVYRQSQQLLNVNRAAHSYVGEYLCVS
                     GSLSGEVCNLKVAEGKHFTRYKEFSTGTEVYTLKNTGGGFTAMKGDSGGPVFSRNLDGS
                     VVARGLISAGVIGAKTETCSNPAANNSPVECYRHIYVTDVPDVLNQHPGMRIAN"
     misc_feature    complement(24843..24845)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(24976..25959)
                     /locus_tag="IE248_RS34550"
                     /old_locus_tag="GCM10010336_70550"
     CDS             complement(24976..25959)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025780.5"
                     /locus_tag="IE248_RS34550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_70550"
                     /product="deaminase domain-containing protein"
                     /protein_id="WP_190032786.1"
                     /transl_table=11
                     /translation="MTTPAYVNRASLRYSIAFIGYPDLEGEVESVSHRALRGDNHYQDL
                     PEPAEWTGALKGIQHRKDAERQVVNLLADEIYRHLGCRSTAQYRARIRAVRRGTVDLYS
                     DMGPCHSCRSVIKDFRVDFPTLAVQVRYRNALRGGGSAALIPAGDGLYGNYGIGDAAQR
                     GDGQWVKAYPGDPVAAATATFDVKVAGPDGDRFRGTATAIDQQPHAPYLYPAPKVTAVP
                     LDEVAAALDTVARSISDQLAPGQRMRPQSFRRWIQGIDQGTVALSCERGPGQAGRAAVA
                     AFVADFPKVRVEVAYPAAAAHAAGHGYADATGQPGGGWLKVFAASR"
     misc_feature    25957..25975
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.88"
                     /tool="antismash"
ORIGIN
        1 acgaggacgg ccacggccgc cgcgacgagc gccgatccga gcgcgaccga gtggaagatc
       61 cagggccagc cccacgcctg ggtgagcaca ccgcccagca ggacgccgcc ggctccgccc
      121 gcacccgaga ccgcccccca cacgcccagc gccctgccgc gccccgggcc ggaggggaac
      181 cggtccatcg ccagggccag cgcggccggc gcgatggctg cggcgccgag gccctggagg
      241 gcccgggccg cgatcagtac cccggcggag gtggccagcc ccgccaccag cgaggccagc
      301 gcgaacaggg cgagcccggc gatcagcacc cggcggcggc cgaagaggtc ggccagccgc
      361 ccgcccgcca ggagcagcgc cccgaacgcc aggccgtagg cgttgacgac ccaggtggtt
      421 ccgccgtccg agaggccggc cccggcacgg atctggggga gcgcgacgtt gacgatcgag
      481 gtggcgagca tgaccgtgaa ctgggccgcg gcgagcgccg cgaggaccgc tcccgggcgg
      541 gggccccgtc tcgctgccgg gcccgtctgt gtgcgtgctg cgttcatggc gcacagactc
      601 gtaccgggcg gtgtccacta tccaggcccg gcggggacgg gcgctgtcca ctcctgtccg
      661 cccctgtcca cccggccccg ccgaaggcgt acggcagcca cccctaccgg ggccgcagct
      721 cccgctgcca caaggcctcg cacagcatgt ccagcccctg gcgcaggtgg cggcggtagg
      781 tgccgtacgg cagcccgagg cggcgggcgg cggcctcctg ggtcggcgca ccggagaagt
      841 ggcccgccgt cagcgcctcg cgggcgcgca ctccgcgcgg gtcacgagcc aggtcgtcca
      901 cggccccccg cagcagggcc cgcaactccc cggcggggtc ctcgaaatcg gccgcgagcc
      961 ggctgcgcat cagcgcgcag gcggcgaagg cgtccgcgtc gcgccagtgc gccagcgctt
     1021 cgcgcaccgc ctggtcgaac gcggtgcgcg agacgggcga cggcccgggc ggcgggacgg
     1081 tcacctcggt ggccgatatg aagcgctgga gccaggcctc cacgggcacc tcgcgccagt
     1141 cgacgccgaa caccccgtag gtgtgctcac ccacccgcgg gcgcgccccc gtgtcgtgga
     1201 gggtgccccg gacccgcccg gcccaggtct cggcgtcctg gtagaccgcg aacccgtagg
     1261 cgcggccgcg ggcgcgggcc gcctccgcct gcgcccgcga actgctcagg tcgatgacgc
     1321 gcgagggaac ctggtaccgc tcggggtaca ccgagaagcg gctgacgccg atgtgctcgc
     1381 cgggactcac cggcgcggtg gcatcggtgt accgccacgc ggcggccacc acggggtcgg
     1441 tggccaggtc ctgggggtcg gcgggggccg gcaggaccag ccgcgccgtg aacgccacga
     1501 tccggcccgt actcacgagc cggtagacgc tgaaggcctg cggctggcgc cgcgcccagt
     1561 agcggacgag ttccgcggac gccgccccct cggtctcctc cgtcatgcgc agtacgacat
     1621 cgatgtcagc cggctggagg ggacggtcgt ggacctcgtc ctcacgggac caggagcgca
     1681 gccgcgacag cgtcgcgccc tcccggaaga ggtagaagag ctcgtcggtg acggtccaca
     1741 cccgctcctc gggggcctcg cgcaggaggc gcaggtactc gtccgccagg cgccggcgca
     1801 tcgcctcgaa ggcgttgggc gcccgccagc gcaggtcggc ggcgagcgtc tcgcgcgcgg
     1861 cgtcgtgcgg gtggagcccg cggtgggtgg actcgatgaa gggcaggtcc cgcagccagg
     1921 agaagagctg atgggcgtcc tccccgggca gcaccgcggc gaggagctcc tccgacgtcg
     1981 agtgcgcctg cgacgccacc tccagggcgc gccggtgggc cgccgtgggc acctccccga
     2041 tcagccccgc cagcagggtg cgcaggacgt ccgccgtggg agcccagatc tcctgcctgc
     2101 cgcagccctc cgatcccgcg gcggccgcga gggacagggc cagcggattg ccgccggcga
     2161 agcggagcac ccggtcccgt agttcgggcc ggatctccgc cgccaccagc agactccggg
     2221 cctgctcctc ggagaacggc tccagctcgc tcacgtgcag gagacgggcc caggcgggat
     2281 ccgcggtcca ctgcggctgc ggagcgcgcc gcccggcgag gacgaccagg gtgtcgtccg
     2341 cggcgcgggg caggaagtgg tgccacagcc agctctccag ccactggcag tgttcgaagg
     2401 agtccacgaa caggaccgtg cccggaacgt ccaggaaggg gccggcggcc tgctcgaagt
     2461 ccaccgggtc ccggctgacg aaccggccgt cgagttcgac gagcagccgg cccgccgcgc
     2521 gggcgtggtc cgccaggcgc cgcagcaggg tcgacttccc tatgccgccc ggcccgtacg
     2581 cgtagaacgc gaacggcgcc cgcggatcgc ccgccaacgc ggcaccgaag cggccgagtt
     2641 cctcgtcccg acccacgaag gcccgtacgc gcgctctgct gagtctttcc cccacggaca
     2701 ccatggcggc tcccatcccc ttgttccagc ccgattccgc ctccggggcc gctacttcgt
     2761 cggtgatcct aacggagcct gcgggcaggc cggttgtgtc gttccgtggg ccgcgaccgg
     2821 cgccgcgtca gcgtacgggg gtgaagtcca gcgacagcga gacggggccc cgggtgtaca
     2881 gaccggcctc ccggtagcgg aagccggggc tgaagcggac ccggtcgagc cggggcagga
     2941 gcatcgcggc cacggtctcg atctcggcgc gcgcgaaggc cgcgccgacg cactggtgga
     3001 gtccgctgcc gaacgagagg tgctgcgcgg ccgcggtgaa ggagcgggcg gtgcccaggt
     3061 ccgggcggtg gatgtcgaag gcgtccgggg cgccgaaggc ggcggggtcg cggttggccg
     3121 cgccgatcac gcagaagacg gtggcgcccg ccgggacggt cgcgccggcg aacacggtgt
     3181 cctcctccgc ctggcgggga atcagctgga ccggcggggt gtagcgcagg gtctcggcga
     3241 tcgcggcggt cagcagctcg gggtcctcac ggacctcggc cagctgcccg gggtggtcga
     3301 tcaggtgctt gaagagcagg ccgagggtct tgtccgcggg ctcggtggcg gcagccagga
     3361 cgttgatgat cagggcggtg acatcgcgat tgctcatggc gatgccgtcg aactcggcgg
     3421 tgcacagctt cgatatcagg tcctcgccgg ggtggcggcg ccggtcttcg atgacgggga
     3481 ggaggtacgc ctccagttgt tcggcgcact ccaggcagtg ccggcggcgc tcgggggtga
     3541 ggtcgagact ggtgatgaac tcggcgaccc cgctgtgcca ggcggccacc cgccgcgcgt
     3601 cccgtctgtc caggccgagg acgtcgagcg tcacgttgac ggcgaagggc ttgccgaagt
     3661 cgttgaccag gtccatccgg ccccgggcga ggaaaggggc catgatctcc tcggcgttgg
     3721 cgtggatggc gcgtatctgg tcctggaggg cctggccggt gaaggcccgg acgacgatcc
     3781 cccgcttggc ggtgtgctcg gccccggtca tctgcgcgag gaccggcccg cgcatcaccg
     3841 gctcggcgcg cacctgaagc gtctcggtcg tgaacgcctc gtgatcggtc agcacccgct
     3901 tgacgtcctc gtggcgggag aggaagtagc tgtcgatcgc cggctcgtag tgcaccggag
     3961 cccgctcccg cagctgtgcg aagtggcggt acgggtcggc ggagaagtcc tcggacagga
     4021 cgctgaaacg gggggtgacc tggggcatgg cgaggaagac ctctcaggaa ggagcaagag
     4081 ccggggaagc cgggaggctc acccgcgcta caggatgagc gaatggcggc acaggttccg
     4141 ttcgcggcgg caggtggcag gcggcaggcg gcgcaagggg taccagacgg cctcggcctc
     4201 cgcttcggta gcagccggtg ccgtcggtgg gcccctgccg gggtgttcag cctcgcggcg
     4261 ggtgggtggc cagccagtgg cgcgcgatct gttcgcgcgt ggcgatccag gctccgccgc
     4321 gccgcgcgac gtgcttcagg aagccgtcga gcgcgcggat ccggcccggc cggccgatga
     4381 tccggcagtg caggccgacg ctcatcatgc gggggcggtc accgccctcg gcgtggagcg
     4441 cgtcgaaggt gtcgatgagg taggcgagca tgtcgtcggc ggtcgtgaag ccgtgcacca
     4501 gcaggaactt gcagtcgttc gcgtcgaggc tgtacggcac cacgagatgc gggcgcccgg
     4561 ccgactcgac gtagaacggc aggtcgtccg agtagtcgtc ggagtcgtag aggaagccgc
     4621 cttccgccgc gaccagccgc cgggtgtggg ggctcgtccg gccggtgtac cagccgacgg
     4681 gccggcggcc gacgagccgc tcgatcgtcg cgatcgagta cgcgatgtcc tcgcgctcgg
     4741 tgtcctgcgg tacgtggcgg tagtcgatcc agcgccggcc gtggctcgcc acctcccagc
     4801 cggccgcccc catcgcccgt gccgcgtccg ggttgcgctc cagggcccgc gccaccgcgt
     4861 agacggtcag cggcgcgccg tgcgccaaga gcgtgcggtg gacgcgccag aaaccggcgc
     4921 gcgatccgta ggcgaacatc gactcgacgt tcaggtcgcg cccgccgacc acgggcggcg
     4981 cgccgacgag ctcgtggagg aagccctcgg aggcggggtc gccctccagg acgttctgct
     5041 cgccgccctc ctcgtagttg aggacgaggc tcacggcgac gcgggcgccg ccgggccagg
     5101 cggcgtgcgg cggctcggcg ccgtaaccga cgaggtcgcg ctggtgctcg gacacgggcc
     5161 gcaccctatc gccgatcggt cgccggaggt gccggggaac gccgggagac gggcgcgcgg
     5221 cgctatatcg aaattccacg gggaatacca ccccggcaga aaggagcgcg gccgaaatcg
     5281 catcggaatt ctgtgcgaat ttcgatgagg gtgtaagggt ccgcacgtct ccgacctccg
     5341 cctgaaccgt tgttcgccct gcgccggttc gattcggcgg cccctcgccg ccctttcaat
     5401 ggcgcgtaat gcatcctccg gtccgatgaa ctacaacgaa atcgcccttc aggtcagttg
     5461 gccgtagtta ggctcccgcc caccggtcag aagatccctc aatccatggt tcgaggaagt
     5521 cgatggcgca agaaaacatt ccacctgaag tccgccgccc ggaggctccg gcccactggc
     5581 cgctgctggt gatcgcggcc gtcaccgccg cctgcgtggc cggaacgctg ttttcctcct
     5641 cggaaccggt cgtcttcgtc tggacggccc tgggcgcctc ctgcaccgcc gcggcgctcg
     5701 tcgaggccat gcggcgcggc cgcgccgcgg cggacgggcg cgcccgcgtc gccgaactcc
     5761 ggcacgccct gtccaggcag gaggacgagg ccgtccgcct ctccgaggtg gtgctgaccg
     5821 aggccatcgc ccgcctgcgc aagggggagt tgcccgagga ggtgctgaac tccgtggccg
     5881 gtcgcgcggg gcgcagcgcc cgctggggct cggacggagc cctgacgccg cgcttccgga
     5941 ccgctctgcg gaccgtactg gcccgggtgg tcgacgccgt cgacaacgag gagagcctgc
     6001 gcgactcggc ccagcgggcg ttcgtgaaca tcgcccggcg cgtacaggcg atcgtccatc
     6061 agcaggcgca cgaaatgcgg gagatggagg agcggcacgg ccgcaatccc gacgtgttcg
     6121 gcgacctcct gcgcctcgac cacggcaccg ccctcgtcgg ccggctggcg gattccatct
     6181 cggtcctggg cggggcccgc cccggccgcc agtggagcag ggccgtcacg ctgtacagcg
     6241 tcatgagggg cgcgatgtcg aggatcatcg actaccagcg ggtcgagctc cactcggtct
     6301 ccgaggtcgc cgtcgtgggg cccgtcgtcg aaccgctgat ccacgccctg gccgaactgc
     6361 tggacaacgc cacgcggtac tcgccgccgc acacccgggt ccacctcacg gccgtcgagg
     6421 tgcagtcggg aatcgccgtg gagatcgagg acggcggcct cagcatgagc gacgaggccc
     6481 gccgccgggc cgagcggctg ctcgcgcagg cacagtccgg catcgacctc aacgacctcg
     6541 gcgagacgcc gaggctcggg ctggcggtgg tggggcgcct ggcgcaggcg tacggcttcc
     6601 aggtctccct gcgttcctcc gcgtacggcg gcgtccgcgc cgtcgtgatc gtcccgcagc
     6661 acctgatcac cacggcctcc gccgccaccg gcctcgccca cggcatcggt tcctcctcgg
     6721 ggccccgggt ggtgtcgccc accgcgcgcg aacaccccgc cgaccacatg gcgtccggcg
     6781 cgcccggagc gttcggtgcc cccgcctcgg cccgcccgtc gacctggccc ggtacgcccg
     6841 tgagccggcc ggcggcgccg ccggtggcag ggccgatgcc gacgcccatg ccgacgacca
     6901 tgccgacacc gcttccggag ccgaccgtca ccggcgaagg cacgccggtc acctcgcgca
     6961 ccgccaccgg tctgccgcaa cggcggcgga aggaccgtgc catcacctcc gacgtctctc
     7021 ccgccacagc gccgctcccg acggcggacg caggccccgg catgtggctg gaggcgttcc
     7081 acagcggact gtccggcgcg cccggccagg acggcgaggg cgtgtcgggt tcagcgaccg
     7141 aaggggcgta acacagtgat cacacagcga agcagcagca tggactggat gctcaaggac
     7201 ctggccgtgg gagtgccgca gacccggcac gtcatcgtgc tgtccgcgga cggcctgtgc
     7261 gtggcccagt acggggccga gaccgacacc gccgaccggc tggcggcggc ctgcgccggc
     7321 ctgcagagcc tggccggcgc cgtcgccgcg gaactgcccc actccaaggg ccggatgcgg
     7381 ctggtcgtca tcgagatgga cgggggcttc ttctacctca tggccgccgg tgacggctcc
     7441 tacctggccg tcctcgccga cgagggcgtc gacgccggac tgatgggcgc gcagatgcgc
     7501 aatctggtga cccgtctggg cgaccacctg agcactccgc cccgacatga cgggcaaccc
     7561 gagtgaccga gccgcccgga agctgggagg acggcggacc cgaacggctc tacgtcatca
     7621 cgggtgggcg cagcgaaccg tccatcgcga cccggctcga cctcgtgagc ctggtggtcg
     7681 ccagggcggc cgtccggccc gagatgcagc ccgagcaggc ggcgatcctg cggatgtgcc
     7741 aggcacccct ggccgttgcc gagatcgccg cccacgcggg tctgccggtg agcgcggtca
     7801 tcgtgctcgt cgcggacctg ctggccgccc agcacgtaca cgtccggcca cccgttcccg
     7861 ccgcccagct acccgacctt gctctgatcg aggcagtgat cgatggactt cagagactct
     7921 gacgcacccg ccgggccccg cggcgcggac gtgctcccgc agacggcggc cgccgccgtc
     7981 aaggtggtcg tcgtcggcgg cttcggcgtc ggcaagacga cgatggtggg agcggtcagc
     8041 gagatcaaac cgctcacgac cgaggagacc atgacccgcg cgggcatagg cgtggacgac
     8101 acccgcggcg tgacccgcaa gaccacgacg accgtcgcca tggacttcgg ccgcatcagc
     8161 atcaacgacg aactcgtgct ctacctgttc gggaccccgg gccaggagcg cttctggttc
     8221 ctgtggcggg gtctcttcga aggcgcgctc ggcgccatcg tgctcctcga cacccgccgg
     8281 ctggagatca gcttcgacgt gatcggccgg ctggaggagc ggggcgtgcc cttcgtcgtg
     8341 gccgtcaact ccttccccgg tgccccggag cacccggtcg aagaactgcg cgaggccctc
     8401 gacctgccgc cggcggtccc gatcctcgtg tgcgacgcca gaaggcggga ctcgtcccgc
     8461 gatgtcctgc tgaccctcat gcgctacctg tactcgcagg cggcaaccca ggaggcaatg
     8521 tgagtacccg tcccaccccg ccgccggagt gcccggccca cgcccccggc gccgcgggcg
     8581 gcctgcaccg gctgcacgga ccggaggcgg aagccgaccc gatggggctg tacgagaaac
     8641 tccgtgccga gtacggtccg gtggcccccg tactggtcag cggggacctt ccggcctggc
     8701 tggtcctcgg ccaccgcgag aacctggacg tggcgcgcac cccgtcgcgg ttcgcccgcg
     8761 acccgcgggg ctggcgggac atgcgggagg gcagggtccc ggcggacacc ccgctgggtc
     8821 cgatggtgac ctgggtgccg gtgtgcaact tcacggacgg ccccgtccag gagcggctgc
     8881 gcggcgccgt cgtggagtcc ctggagcgct tcgacaagcg cggcatccgc cgctacgtga
     8941 cgcgcttcgc caaccagctc gtcgacagga tcgccgggga cgggcacgcc gacctggtgg
     9001 ccgccttctc cgaccagctc cccatgctgg tgatgacgca actcgtcgga gcccccgacg
     9061 aacacggacc cctgctggtc aacgcggccc gcgacatgct ccagggcacg gagacggccc
     9121 tgcagagcga ccgctacgtc accgtcacgc tggagcagct ggtcgcggac cggaaggccc
     9181 aacccgcccg ggacctcgcc tcgtggctgc tggaacaccc ggccaacctg agcgacaccg
     9241 aggtgctcat gcacctgcgc gtcgtgctga tcgcggcgta cgagaccacc gcgaacctga
     9301 tcgccaacac gctgcggacc gtgctgaccg accagcgctt ccgagccagc ctctccggcg
     9361 gccacatgac cctgccggac gccctagagc aggtcctctg ggacgagccg ccgatcaaca
     9421 cgatcatcgg gcgctgggcc accggggaca ccgtcctcgg cggccggcag gtgaaggccg
     9481 gcgacatggt cctgctcggg ctcgccgcgg gcaacgccga cccccagatc aggcccgacg
     9541 cgaacgcctc cgtgcggggc aaccgttcgc acctcgcgtt cagcagcggc ccgcacgagt
     9601 gccccggcca ggacatcggc cgcgcgatcg ccgacaccgg catcgaggtg ctgctcgacc
     9661 gcctccccga cgtacggctg gcgatcgacg cgagtgaact gaggtggcac ggcaccctca
     9721 tgtcgcgcca cctgctgtca ctgccggtac ggttcgcccc gcgccccgtc aaggacgccc
     9781 agccgcagcc gcatccgtac caggagcagc ccgcggccca cccgccggtc ccatcggctc
     9841 tgccggcccc gttggtcccg ccgcagccgg cggtcgcgcc cgcgccggcc ggccaccgcc
     9901 gcaagggcgg ctggtggcac cggctcctcg gccgccgctg acgcgggcgc gcttcgcccc
     9961 gggggcccgc ccggcacggg ccgggccccc gcggttcctc tcaggagcgc aggtgggtcc
    10021 accacgaggc gagggccggc agatccggtg gccccgtccc ggggtcggcg ggcagatcgg
    10081 agtaccggac cgcgaaccgc gcgtgctcca ggggcaggtg gtggcggttg cgcgggcttg
    10141 cataccgagg cgcccggctc tgccaggtga tgcacccggc cacgtagtgc tccagcgcct
    10201 ccagccggcg ccgcagcggg gcgtccgccc cggccgccaa ctgcgcccgg agcgcgagga
    10261 agaggaccat cacccgatcg cgcagggcca ccgccgccgg taccgccccg gcgggcggac
    10321 agttctcctg gtgggcgatg acgttgatca gattcacctc cctcggcacc aggtggtcgt
    10381 ccttgtcgta cgagaagagg tcgttgtcgg cgctgacgac gaaacccgcc gcgtcggtca
    10441 gcgcctccag cgcgggggag tagagcacgt ccgccggcaa ccggatgtcc cgcgctacat
    10501 ccgaccaggt cagcgagaag cgggtgccgt tcgccaggga ccccagggcc gcgaagtcgt
    10561 tcagggtcgg catcaccccg ctctccgccc ccgccgcctg ccaggccgcc ccgagcagcc
    10621 agtcacgcgt cccctcgacg aacctgcgca gctggaaggg ggtcaggagc gcgtgggtac
    10681 ggcgtacgag gtctgccaga gcgcgtgtca cggcactgtc ggggagcagg gccgcgcccg
    10741 gatcctggag ggtgcggacc agtcgcgcgc cgtggtcgac gacggccgcg gtccgtacct
    10801 cggcggcgcc cgagtcctgc cagtcgtcaa tggcgttggc ccagtagttc cactcggtga
    10861 acagcagcag ggcctccacg tccccctcgg gaatgaggcg gcaggagaag tcggcgctgt
    10921 gcgtggcgag cccccacgcc cgctccaccg ggtcccggta caggccgaag gcgtccagcc
    10981 attcgaccgc gcgggcctcc acctgcttcg cctcgggatg tacgaggccc tgcggcagcg
    11041 ggcagtagaa ggcgggcagt cgcgggccga ggcgggaggg ccgcgggcgg tgtgccgtgg
    11101 ccatcagctc cccccgagcc ggaagagcag gagccgcgtc tccagggcgt gatcgcgcca
    11161 gaggcggaag agcttgctgt gcgcgatcgt cgactcgccg agccgctccc gggaccagga
    11221 gccgccccgg ccgcccgcgc gcagccggtc gagttcggcg gtgttccagg ccatggactg
    11281 caaccagaac tccgccaccg cgtcggtgac gtcctcgtcc cgctccagcc cgaagccggc
    11341 cgcctccgcc gccgccaggt actccgtacg ggtgccgagc cgggttctgt agtagccgtc
    11401 gacgaagtcg cgccactcgg gccgacacac gaagtgctcc tggatgccga accacccgcc
    11461 gggcttcagc gccttcgcga cgacctcgaa gagccgggcc cggtcggtgt agccgctgct
    11521 ctcgttggcg tacgcggcgt cgtagacccg ggtggcgtcc aggtcgtgca cgttccccgg
    11581 gacggcatcg accttgtcct cgacgcccgc ccgccgcgcg aagccctgga tgatcggcac
    11641 gtgctccgcc gcgaccgtga gccccgtgac cgaggcaccg tgttcctgcg cccagtacag
    11701 ggcggcgccc ccgagaccgc agccgatgtc gagcacccgg ccgggcggcg cctcgtacgc
    11761 cttccaggaa cgggccgcgt gctcgactat tcgctcctgc gcgtcgacca ggcggcgtcc
    11821 cagcgttctc tgggaaaccg tgacgtgcgg ggtggcgtcg gcggtgaaca gccccacatg
    11881 gaagtggacg cgggggccgg ggccgtactt ctggaggatg tcgcccgtct tgcggctgta
    11941 gtagagccgc acccgctcct cgtcgctctc gccccggtcg cttcctaagg acgatacgaa
    12001 tggtgtgacg ctcacgtggt gtccgtccct ccgggccagg gccggttccc gggcaggcgt
    12061 agccgctctc gcccggcgcg caccggcatt ctgttgaagc acggatcatc gtggcacctc
    12121 gtgggcgtcg cgtcagccct cacggacagc tcagggcacg taggacgcag aagaatgctt
    12181 tttgcgacat gccgtacgac gaacaggcgt tggccccagg cgtcccgtgc gcatcccgcg
    12241 ccccgtcagt gacggaaggc gctctcgtcc cccggctcgg actccagcac ctcgcggtcg
    12301 aacgtcagca tgccgaggaa gaacagtcct cccagcagga gcagcccgcc gacgatcacg
    12361 acggcggtga gcgcctccgc gggcgtcacg aggacgaaca gagcgatgag cgtccacgcc
    12421 agcgcgcaga ccgcgaccgg cagttcgagg cggccgaggt cgaacgcgcc cttctgacgg
    12481 gccagatgcc gacggaccgt caggtagagg acgatcgtcg caccgtagat gagggccggg
    12541 aggatcgtgg aggccgtgat cagctccaga agggcggcgc ccggcagcgc gatcatcagg
    12601 acgaccccga tcccgaggac gagcagcgtc gccgggacgg gcgtccgggt acgggggctg
    12661 acccggcgca tcgtgcggtg cgcggggaac cgggaatcgc gcgacatcgc gtagacgagc
    12721 cgggagcagg cggtcatcac cacgatcccg gcgccgaaga aggcgaaggt gatggcgacc
    12781 agcagcgtcc tctccgccac cgcaccgaag cggtcccgca tgatcgcggc gaccggtgag
    12841 gcctcgtggc tgatgcgggg gacgtcctcg atcgcgaggg tgagggtgat gaggaagagc
    12901 atgcccagga ccccggccgc caccaccgac cccacgatcg cgcgcgggac gctgcggtag
    12961 gggtccttgg cctcctcggc caggttggcg gccgagtcga agccgacgag cgtggcgagg
    13021 cccatgatca tggcgagcat cagcccgccg ccgacggcga agtagccggg agcgtgctcg
    13081 gtgatccccc gggaggtgag gttggccgtg gagccgttgc cggtgacggc gacgacgatc
    13141 acgagggcga tcgccaccac cacgacgagg gcgagttcga gtccgacggc agccgagttg
    13201 atccagccga ccagacgcgt ggaggcgatg gccagcacgg cttggacgag cagcaccacc
    13261 agggtgatga cgcgcgcggt gtcctcgtcc gccgcgatgc cggcgagggg catgaacgcc
    13321 tgactggcga gggcgttgtc gatcgcgacc accgcgatcg ccaggtagca gaaggtgagc
    13381 cagccgaacc accagcccac cttgggatcg cccagccgtg aggcccactg gtacgaggac
    13441 ccgctgagcg ggatgcgggc cgcgaactgc gcgaccacca gcgccaccag gctctgtccc
    13501 accgctgcga cgagccacag ccagatcccg accggccccg ccgtcaccag cacctcgtcg
    13561 aaggtcgcga agatcccgac cgcgaccgag atgaaggcga aggagatcgc gaacacctgg
    13621 aaggagccca gggtgcgctt cagctcctgt cggtaccctc ccgcctcgac ggcgctctcg
    13681 ctgtccggcc cctccgtcgg agcttgcgtc actgcggcca cctcactgtt tcttcaggcc
    13741 ccgaccagta tcacctttgg ggtgctccat cacctttgcg gcattcggta cgagcccgtt
    13801 ctgtcacccc tccggggcgg accgttctgc ggatttcttc ggacatccat ccgtgcgtcg
    13861 atcgtggggg cgttccgggc cgctctcggc gcgatcgcgc cccaccgccc cgaggccctc
    13921 cgcggcgcgg atcgacgggg acggccggcc ggagggaggg tggtgacgga gcgactgccg
    13981 gggctgccgg tgtgttcccc ttgcacacgc tccccatccg tgccggcgcc gccggacgcg
    14041 gcggccccgg tcccagtgat ccatcccggt cggaacgccg acgatccccc ggcgccggca
    14101 ggggacacgg ccgatccgcg agggcctgcg cgcgcctgcc gcgcgccacc ggcgcgccac
    14161 ggcgcgggcc gtcacgccta ccggcccgta cgcctgccgg ggagcgttcg cgttgcgcaa
    14221 ctgccgtgcg cgcgccgttg cgtggggcga gggaggccct gaaactctgg tttgtcgcac
    14281 ggcgcccgcc gagagggggg tgacccccag gccgccgatc gtgcacagct ctctccttct
    14341 tcttctcttt ccccttcttc tcgctgacgt ctgacgtctg gctgctgccg ctcgctgctc
    14401 gctgctcgcc gcctgtccgt ctccgtgtat gtccccgcgt ccaggagtct tcgatggaca
    14461 accagtacga ggcctacacc ttcgccgatc cgctcttcta cgaatccccg cgacgctggg
    14521 gtgcacagga ggagttcgag gccgccaccc gccccctgcc ggcaggctgg gaacgcggcg
    14581 acctggagat gtggtccgtg gtgcgccccg cgggcgtcgt cctgccggac cagggatgga
    14641 agatccacgt gtcctcgtgc gcggcggacg ccgaagccgt gctggaggcg ctccacgcct
    14701 actgcctgag cgaacgcatc accttcaagt tcctgcgcgg cctgcccatc ctccaagtac
    14761 agaactccaa atacgccccg cgcggctcca gcggcaagtt ctgtacggtc taccccgtcg
    14821 acgacgcgga actggagcga tgtctcgacg gcctgggcac cctgctcgcg ggccggcgcg
    14881 gaccgtacat cctcagcgac gcgcgctggg aacaaggccc cctctacctc cgttacggcg
    14941 gcttcgtcga acgccattgc cgcgacgccg ccggtgagcg cgtcctcgcc ctcgccggac
    15001 cagacggcgc tctggtgccg gacgtacgcg gggcggggtt ctccgtgccc gactgggcgc
    15061 cggtgcccga ctgcatcgct cccgccgtcg cggcccgccg cgccacccgc ggaccggacc
    15121 tgccgtacac ggtggagcgc gtcctgcact tctccaacgc gggcggcgtc tacctcgccc
    15181 ggcgcgcgga gggcgatccg ccggtcgtac tgaaggaggc gcggccctac gcgggcctgg
    15241 accagcgcgg agtggacgcc gtcacccggc tgcgccacga gcacgaggtg ctgacccggc
    15301 tggcgggcat ccccggcgtc cccgcgctcc ccggcggcga cccggccgtt cccggcgagc
    15361 agagcctgtt cagcgtgtgg gaacacgagt tcctcgcgca ggaacacatc gacgggcagt
    15421 ccctcagcca gtggctgacc ggccactacc cgttgatcca ccccgacccc gacccccaga
    15481 ccgtcgccga gtacacccag gaggccctgg ggctggtgga gcgaatagaa aggacgctgg
    15541 ccgccatcca cgcccgcggc atagtcttcg gggacctcca tccccgcaac ctcatcgtcc
    15601 ggccggacgg cgagatatgt ttcatcgact tcgaactcgc cagtcccgcg gacgccttcg
    15661 tccggccggc cctcggcgcg gcgggcttca ccgcaccggc cggctacagc ggctccgaca
    15721 tcgaccacta cggcctgtcc gccatccggc tctggctgtt cctccctctg gtccagctca
    15781 ccgccctgga tccggccaag gcggacgagc tcgcggacgt catcgagcgc cgcttcccag
    15841 tgccctccgg ctacacggag cccatccgcc ggatgatcgc cgccccgccc gcccccgccc
    15901 cgcccgccac ccggaccgcc cgccccggca tcggccacgg ccgggaagcg gcccacgccc
    15961 tgctcaccgc caccccggcc gactggccgc ggctgcgcga ctcgctggcc gagggcatca
    16021 cggcgatggc caccccggac cggacggacc gtctcttccc cggggacgtc gcccagttcc
    16081 ggcacggcgg cctcggcatc gcccacggag cggccggcgt gctctacgcc ctgcacacca
    16141 cgggcgccga ggtgcgcgag gaacacgtcc gctggctcgt ggacgcctcc cgcacccgga
    16201 tcaccgcccc cggcctgtac ttcggcggac acggcgtggc ccacgtcctg gacctgctgg
    16261 gcgaacgcga ggcggccctc gccctgctgc ggagcctgga ggcggtacgg gaggagtcca
    16321 ccggcccgtc cctggccacc ggcgcccccg gcatcagcct gacgctcctg cacttcgcct
    16381 ccgtcacggg cgaggcacgg ctgctggacg aggcactcgc cctcgcccag ggagccgccg
    16441 acaccctgga gaagaacggc cgcaccgacg gacgccggcc cgccggcctc ctggccggag
    16501 cctcgggagc ggccctcgcc ctgatccgcc tgtacgagca caccggcgac ggcgccctgc
    16561 tggagcgcgc ccgcaccctg ctggaactcg acctcgaccg ctgcctcacc gtcgcggacg
    16621 gcaccaccca ggtcgtcgac ggccggcgcg tgctcccgta cgtcgaaacc ggcagcgcgg
    16681 gcatcggcct cgtcctgaac gcgctcctcg cgcacctccc cgacagcccg gcggtgtcgt
    16741 acgagccgag catccgccgg gccgccgaac cggagttcat catccagccc ggactcttca
    16801 acgggcgcgc cggcctgatc ggctacctgg ccctcaccgc ggcccgcgcg gacgcgcggc
    16861 acaccgggcc cgggcacacc gcggccctcc tggaccgcca ccgcgccctg ctggccctcc
    16921 accagatcac ctaccagggg cacctcgcct tcccgggaga ccagttgctg cggctctccg
    16981 cagacctggc gaccggcgcc gccggggtac tgctggccct cggcacggcc ctgggcggca
    17041 cccccttcct gccctggaca gggtgacagg cgcttctcgc gcccccacat acccccggcc
    17101 gccggccggg ttctccaccg ctcaccgaag gagatcagtc atggcgatcc tcgacctgca
    17161 gaccctggag ctccccgaga ccgaggcgca cccgatcgac gacaccctgg cgagcaccag
    17221 ctcgctgagc gtcctcaact gcggcaccag cacggtcagc acgctcgtct gcctctgacc
    17281 gccgccccgc cgcccctgag ggggcggtag caccgccgca ccgcacgaaa ccggccgggc
    17341 cacagccgta ccagggcccg gccggccctc cgggccggag cgcacgccgc tccggcccgg
    17401 gctcgtgcca cgggccacca ccgttcgccc caccgttcgc ccgcaccagc aggagggttc
    17461 ttcgtggccg accagaccgc aggcaccgta cgtccggcac gcggccacga caccagccgc
    17521 accgcaccgg ccacggtacg gctgcgccac gaactcggcg cggaaccggg ccggttgtcg
    17581 gccgcgatcc tgttcgccct cgtcgccacc ggggccaccc tcgccctgcc cctgttcgta
    17641 caagaagtga tcacggacct ctccggcagc cgccccccgc gcgcccacgt cgtcatgatg
    17701 tgcgccgccg ccgtgggcgg agccgtgacc caggcgctct ccggtttcct gctcgcccgt
    17761 gtcggcgaac gcctggcctg ccgcgtgcgc atccgcatca tggagtacag cctgcgcctg
    17821 cccctggggg tggtgaaggc ccagggcacc ggcgatctcg ccgcccgcgt cacctcggac
    17881 gcgctcctgc tgcgccaagt cgtcgacatc gccacccagt tgcccctggc cgcgctgacc
    17941 gtggcggcga ccctggcggt catggtgtgg atcgactggg tgctcaccct cgtcacggtc
    18001 ggcgcactgg ccgtgctgac cgtgctcatc ctgctgatcc tgcggcggat gaaggacaac
    18061 gtcagcggac agcaggtcgc catcgggcag atcgcccagc gcttcaccgc gaacctggac
    18121 gcgctcacca ccatcaaggc gtaccgggcc gaggccctgg cggccggagc cctcgccgcc
    18181 gacgcggagc ggctgcgggc cgtgtccctg gaaggcgccc ggctcggcgc gatgatcccg
    18241 gccgtgctgt ccctggggaa ccagttcgcg atgatcgcgg tgatcctgac cggcggggcc
    18301 cggctcgccg ccggggacct gagcatcgcc gccttcacgg ccttcctcct gtacctcctc
    18361 cagaccatcc cctacgtgag caccctcgcc accggcttcg gccggctgca agccggcctg
    18421 gccgcccggg accggtgcaa cgaactgctg ctgctggcac cggagaccga cccggcgggc
    18481 gccgcactgg acccgccgac cccgctgccg gacgcaccgt ccgtgatctt ccggtccgtg
    18541 tcctacaccc accccggcgc ggacgaagcc gccctgcgcg gcatctcctt cagcaccgcg
    18601 cgcaccgggc tgaccgcggt cgtgggcccc tccggcgcgg ggaagagcac cacgctctcc
    18661 ctgatcgacc ggttcatccg gccctcgtcc ggctccatca ccgtcctcgg ccacgacacc
    18721 cgccactggc ccctggacgc cctgcgggcc cggatcgcct acgtggacca ggagttcacc
    18781 ctgctggagg cgaccgcccg ggagaacctc cagctcggcc gggacggacg ggccagcgac
    18841 gccgaactgg cggcggccct cgacgcggtc ggcctcgccg aggacatcac acggctcccg
    18901 cagggcctcg acacgccgct cggccgggaa tccgacctct ccggcgggca gcgccagcgg
    18961 atggccctgg cccgcgccct gctctcggac gccgacatcg tcctcctcga cgaaccgacc
    19021 agccagctcg acggcctcaa cgagcagcgg ttccgcgccg tcgtctcgga cctggcggcc
    19081 acccgggcgg tcatcgtcgt cgcccacagg ctgtccacgg tgcaggaggc ccgccacgtc
    19141 atcatgatga gcgacggcgc ggtcctcgac gcgggggacc accccaccct gctgcgacgc
    19201 tgcgtcccct accgggccct cgtcgccagc cagtcggtcg ccgcccgctg agccgaacgg
    19261 cgtacggggc ccgcggtgca tccccggcgc ccgtaccctc cgaaggaggg ggtgagacac
    19321 gacgtcgacc cctgcggagg ccttcatgaa cggcgcggac gcgcagagcc cggtgatcgt
    19381 ggtgggagcc ggactcgccg ggctgacctg cgcactggac ctggtccggg cggggctgcc
    19441 ggtgcgggtc ctggaggcgg ccgacgaggt ggggggccgg gtgcgcaccg accgccgcga
    19501 cggcttcctg ctggaccgcg ggttccaggt cttcaacacc tcctaccccc aggtcaagcg
    19561 ccgcatcgag ctggcccggc tgaggctgag acccttcacg cccggcgtcc tgatccacac
    19621 ggcggaggga ggccggctca ggttcaccga cccgacccgg cgcccctcgg acgccctcgc
    19681 gctcctgacc ggcaagcagg atcgggggcc ggggccgggg ccggggcagg ggcagggtcc
    19741 cgggccgctc gcgctggccg ccctgggacc gctgtgcgcc ctcgacctcc tcgccccgcc
    19801 ccggctcctc aagcggctgc ccgagctcac cacccgcgag gaactcgccc gctggcgggt
    19861 gcccgaccgc gtcgtggacg gcttcctgcg ccccttcctg gccggggtgt tcctggagga
    19921 cgacctggac acctccagca ggatgttcca cctgacctgg cgcagcatgc tgcgcggaac
    19981 cctcacgctg cccgccgacg gcatgggcgc ggtgccccgg cagctcgccg aggacctccc
    20041 gcccggctgc gtggaacgcg cgagcccggt ggcggcgctc tccgcggccg gggtgacctt
    20101 cgccgacggc agcgcggccg aggcccgcgc ggtggtcgtc gccacggacg cggcggccgc
    20161 ccgctccctc gtacccggac tgccggccgt ggcgacccgc acggtcacca cgtaccacca
    20221 cgccgccacc cgctccccac tgcgcgagcc gacgctcctg ctcgacgcgc gacggcggat
    20281 cctgaacacc tgcgtcctga cggaggtcgc gccgacctac tccgccgacg gccgcgcgct
    20341 gatctccacc tccgtcctcg gaacggacgc gccgggacgc gaggccgccc tgcgcgaggt
    20401 cctcgccgag ctctacgcga ccggcacgcg ggactgggaa cgcgtgggca cgaccacggt
    20461 cgccggggcg ctgcccgcca tggtcccgcc gtggccgctg agccggaccg gccgcaccgc
    20521 ctccggcgtc tacgtgtgcg gcgaccaccg ggccaccggc tccgtacagg gggcgatggc
    20581 ttcggggacc cggaccgccc gcgagctcct cgccgacctc aggaggccat gaggccggac
    20641 ggccggacgg ccggacttcc gggccggacc gctcccggcc cggccccggc gccgggctgg
    20701 tcagcggttg gaccagagct ggccgggcgc ccccgtgcag ggcatctggc gcacctcgcg
    20761 gcggctgccg gacggcatgc ccgcgtcctc caggcacagg ccggacacac ggttcttgac
    20821 ggtggcactg gagccgttcc agccgaagtc ccagcgctgg ccctgggagt agttgcagac
    20881 ccgctggacg atggtggccc ccgcttccag gccggacggt tccaggcaca ggttcgagac
    20941 gtgcgccggc ttcaggtcga ccgaggggtc accgaggacg gtgtcgctcc agaactcctg
    21001 gtggagctcc tccttgcagt tgaactgctg gagcaggccg tactcgtagc gggaggcgcc
    21061 gcggatgtcg aggcacttgc cggtggcgac gttggcgtac tggaacctgt acgccgtcat
    21121 ggtgacggct ccggtggcgg cggtatcggg ggattcggcg ggcttcgcct gggcgggcgc
    21181 ggccagcacg gtggcggccg acaggaccgc ggcggcgacg actgcggcac ggacggcgga
    21241 cgagcgcggg gatcgcatgg tcgggtgttc tcctcacctg gtgatcgggc ggccggacgg
    21301 cgcgccgtcc gggggacggg cggccgcggt gtgcgttccg gcttcggccg tcagtcttcc
    21361 ggggcgccgc gatcggggtc gaagcccttc gacgtccctc gaatccggac atccgcaccg
    21421 cccgcgcggt gccatccggc cagaagttcc gccgccgggc caccgcgtcc cgcccgccga
    21481 ctagcgtgcg gcgcggccga ccccgggaga acgacggtgc tgcggatcca cctcacccct
    21541 gacgacctgg cccgcgtgcg catcgcaccg gcccccgacc cgctcgccga gacgatcctc
    21601 agcctgcccg tcctccagag ccgcgatcgg ggcggcgcag gactggacgg ctggcgtgaa
    21661 cgcacccgca gggcgctcct gcccgggatg cgccccgtgc tcgaacttgc cccggcccgg
    21721 ccggacgagt acgtgcccga ggcgttcctg cacgccgtga cggccaccct cgcggacagc
    21781 ctcgaccaca cctggtccct ggcacgccgc cagtggacgg ccgacctgca cgccaccgag
    21841 gtgctgcggc ccgatgcccc cgactggatc cgccggctcc acgcggggga gcgggagtgg
    21901 agcgggatcg tccacagcgc ggtcgagcgc taccacgccg tggccgtggc cccgtactgg
    21961 tcccagctgc tggccgccgc ccacgccgac cgcacccggc gggcgctggc cgcggccgac
    22021 accgggaccg gcgggctgct cgcctcgctg caccccgaga tccgctggga tccgccggta
    22081 ctgtccgtgc cctgcgcgtt cgacacggat ctggagcccg cgggccgcgg gctggacctc
    22141 gtaccgacct tcttctggcc gcggcccctg gcgctgctcg acaacgccga accggaacgg
    22201 ccgctcgtac tgcgctaccc cctcgcccgc gacctcgcca cctaccggtc cgtctgggcg
    22261 gcggccgcgc ccaccgggcc ggacggcgcg ctcgccgcgc tgctgggcac cacccgcgcc
    22321 cgtacgctcc aggccgcggc ggtgccggcc ggtacggccg agctcgcgcg ccgcaccggc
    22381 acctccccgg ccaccgcgag ccaccacgcg tcggtcctgc gcgccgcggg cctgctcacc
    22441 accgaacggg acgggtccgg cgtccgccac gcactgactc cgatggggcg ggcgctgctc
    22501 caggatcacg ccctgccacc gccatccgcc tgaccacccg aaaatcagtg atcgtcgctc
    22561 tctggtgacg ggccgtcccg gcgtgtagcg tcagcgtcag ctgtcgtggt tcgcagtccc
    22621 tgcccgcgcc ctggcgtggg cgttctgctg tgtggtgccg gaccaggacg atcacctccg
    22681 gggccgcgcg gtgcggccct gacatcgact gagaggcacg gacatggcca gcggaatcgt
    22741 gaagtggttc aactccgaaa agggcttcgg cttcatccag caggacggcg gcggtcccga
    22801 cgtcttcgcg cactactcca acatcaactc cacggggtac cgcgagctgc aggagggcca
    22861 ggcggtgacc ttcgacgtca cccagggcca gaagggcccg caggcggaga acatcacggt
    22921 cgcctgaccc gcgaccccat cgtgtgacga ggctcccggg gcacgccccg ggagcctcgc
    22981 cccggtcaca gtggtcccgg ggtttccggc gtcacatgct ccagtgctgg taggggttgg
    23041 tgtccccgta ctggtgcacg tacgcgttgc ccttggcgtc ggagtcgagg gccttcctgt
    23101 tctggtggtt cagcagcgtg taggcgttgc cgttcacgtt ccactgctcc caccactgct
    23161 tgacgtcccc cgagttgcag gcgacggcgg caacactgtc gttgcccacc cccttgcccg
    23221 tgatacacag acccgtcttg ctgctctgca gcatcacgcc catggggccc tcgtggaggt
    23281 accagtgctg gtacgggttg tccgagccgc agcccttcgt gtagatcttg ccgccgaagt
    23341 cgccgtcgag gcacagcccg gtctgtacgt tcctgagcgc gacggcgccg cgccccgcgg
    23401 gagcggcgga cgcagaggcg ggtaccgcca ccgcggtcgc gcaggcgagg gcgagcagtc
    23461 cgatgaggcc ggtcgtcttc ttcatctgga tctcctgatc agttggcgat ccgcatgccg
    23521 ggatgctggt tcagcacgtc gggcacgtcg gtgacgtaga tgtggcggta acactccacc
    23581 ggggagttgt tcgccgccgg gttgctgcag gtctcggtct tcgccccgat gaccccggca
    23641 ctgatgaggc ccctggccac cacgctgccg tccaggttgc ggctgaagac gggaccgccg
    23701 ctgtcaccct tcatggcggt gaagccgcca cccgtgttct tcagggtgta gacctcggtg
    23761 ccggtgctga actccttgta ccgggtgaag tgcttgccct cggcgacctt gaggttgcag
    23821 acctcgcccg agagggaccc cgagacgcac aggtactcgc ccacgtagga gtgggccgcg
    23881 cggttcacgt tcagcagctg ctgggactgg cggtagaccg gctggccgga ccagatcgtg
    23941 tagttgtgca ggaatccgcc gtgcgtgggg atcagctcgg tgtcgtacct ctccgaacgg
    24001 tccgacaccg ggcccagctt gatgtcctgg tcgccggcgt accacgtctt gccggcctcg
    24061 ctgcagtgcg cggccgtcat caggtagtcc agaccccgct ggggccaggt gacgacgaag
    24121 cccgacgtgc agatcggccc gcccttgtag cgctgccgca gcagcatccc gccggaatgc
    24181 aggggcgcgt cctgctcgcg ggactccagc ggggccggag ccccggtcac cgtgccggtc
    24241 cacggcaccg gcggctcggc ggtccgggcc cgcccgttcc cgctgttcgt gtcgttcgcg
    24301 cgcagcggct cgccctcgac caggagcccc gatccgtcgg accgggcacc ggccgagtgc
    24361 acgctggtca gctgcccgtc gatggtcagc gaccgcccca tgagactggc cgccgcctcc
    24421 ctcagctcgc tcctgttgta cggcgcggag cgcagctcca cccgtacgcc cttggcccgc
    24481 tggggcgcca cggccgcctc gacctgctcc tcgccgccct tgtggtacag ggtcaccgac
    24541 cggtcctcga cggacacggt cagggaggtg aaggccggcg aatcgccgag cgcgccctcg
    24601 atggcgccgg cagcctcgct caggggcagc tgagcggcgg ccagctcgcc ccaggacgcg
    24661 aaccccgcgg gcggcgagcc tgcgggggcc gcgggggagg gcgccggacc ggtggagcgg
    24721 gcggaggcct gcgggccggc cacgaaggcc gccgccgcga cgaggaccgc caccgccccg
    24781 taggccacgg gccgccgggg gcggcgggga gacggcgcgg agggcagcgc tgtgagctgg
    24841 ggtaacggtg aactacgcac gagcttcctt tcgggtggtc ggcttgccca ccaacctccc
    24901 acccctggcc aacggccccc taacgcccgg ctaacggcgc tccgtccaac gccccgcgcg
    24961 gcccccgagc ccgcgtcagc ggctcgcggc gaagaccttc agccagccgc cgcccggctg
    25021 cccggtggca tcggcgtacc cgtgaccggc ggcgtgcgcg gccgcggccg ggtaggccac
    25081 ctcgacccgt accttcggga agtccgcgac gaacgccgcg accgccgccc ggccggcctg
    25141 cccgggaccc cgctcacagc tgagcgccac ggtgccctgg tcgatgccct ggatccagcg
    25201 ccggaacgac tgcggacgca tccgctggcc gggggccaac tggtcgctga tggaacgcgc
    25261 caccgtgtcc agcgcggcgg ccacctcgtc gagcggtacc gcggtgacct tcggcgccgg
    25321 gtacaggtac ggggcgtggg gctgctggtc gatcgcggtc gccgtcccgc ggaaccggtc
    25381 gccgtccggc ccggcgacct tgacgtcgaa ggtcgcggtg gccgccgcca ccggatcgcc
    25441 ggggtaggcc ttcacccact ggccgtcccc gcgctgcgcg gcgtcaccga tgccgtagtt
    25501 cccgtacagg ccgtcaccgg ccgggatcag ggccgccgaa ccgccgccgc gcagggcgtt
    25561 gcggtagcgg acctggacgg cgagggtcgg gaagtccacc cggaagtcct tgatcaccga
    25621 ccggcaggag tggcacggcc ccatgtcgga gtacaggtcg accgtccccc tgcgcacggc
    25681 acggatccgc gcccggtact gcgcggtgct ccggcacccc aagtggcggt agatctcgtc
    25741 cgcgaggagg ttcacgacct gccgctcggc gtccttgcgg tgctggatcc ccttcagggc
    25801 gccggtccac tccgccggtt cgggcaggtc ctggtagtgg ttgtccccgc gcagcgcccg
    25861 gtgtgagacg ctctcgacct ccccttcgag gtccgggtac ccgatgaagg cgatcgagta
    25921 ccgcaggctc gccctgttca catacgcggg cgtggtcatg cgcacccctc tcagtcccgg
    25981 cgtaccgcgc gaccgcccca cacggccgaa tccctcgccg tacccctggc tccacagggt
    26041 gtcgcagcgg gataaacgaa cgttcaacgc gcccggagcc gtcgcgcgag cgcacatgtt
    26101 cggccacgga aggtgagatc cgggcctcct gcgggtgagg cgtcccatag gacccacgtc
    26161 acatacgagc aggtctagta gcccccgttc cgcccgtaac ggcgcccgag ggcggaccgg
    26221 actcgggtct cccggccccc tgctccgatg tcggctagta acgggggtcg ttgccagggc
    26281 agcggtcggc tggctaactg ggtgatgtcg ccgggcggca cgggtgtttc acccggagcc
    26341 cgcggatccc ctctccaccc gtgtgagtgg ttcac
//
