LOCUS       NZ_BMVE01000015        21008 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence15, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000015
VERSION     NZ_BMVE01000015.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 189377)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 24492
            Orig. end                         :: 45500
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21008
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11008](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11008
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(922..2133)
                     /locus_tag="IE248_RS31340"
                     /old_locus_tag="GCM10010336_63790"
     CDS             complement(922..2133)
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1102: glycosyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049712.1"
                     /locus_tag="IE248_RS31340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63790"
                     /product="glycosyltransferase"
                     /protein_id="WP_190032414.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 1.6e-16,
                     bitscore: 54.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILIATAGSRGDVAPYTGLGAALRDAGYEVALAATESFAPLAEE
                     AGLEFRPLPADPREHGDVQGKSALLRAAAAFVTGLGEGFADAVDAGTDLLLLSATTAPL
                     GWHVTEATGIPSMGVYLQPTAPTGDFAPTVMGARSLGRFGNRAAGRFARRMTDRVYEPA
                     VARLRERLQLPPLTATRMRRRQDRAGWPVLHGFSTALVPRPSDWRAHLAVTGSWWPYFD
                     AGRRLPAELENFLAAGPPPVLVGFGSMAAGHGERLSEIAVQALRRAGLRGVLQSGSAGL
                     VADGDDILTIGDVPHGPLFPWLAAVVHHAGAGTTAAAARAGIPSVTVPIAADQPFWAAR
                     LAAIGAAPAPIPFRSLTADRLTHALVTAVRDPAHAKAATAAARHMSTEDAAGSVVTAVR
                     RLAK"
     misc_feature    complement(2119..2134)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            complement(2143..2930)
                     /locus_tag="IE248_RS31345"
                     /pseudo=""
     CDS             complement(2143..2930)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735222.1"
                     /locus_tag="IE248_RS31345"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGYTVGQVSAFAGVTVRTLHHYDRPDSSHRVAAAGPGTATTKTST
                     WHGSSRSSSTANWAFPWTRSPRSSPTRKPTRWSTCGPGSANWPTRSRDCSNWPRWPSVR
                     SRSSRPGCR"
     misc_feature    3112..3127
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     misc_feature    complement(3190..3203)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.05"
                     /tool="antismash"
     gene            complement(3608..4513)
                     /locus_tag="IE248_RS31350"
                     /old_locus_tag="GCM10010336_63830"
     CDS             complement(3608..4513)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718147.1"
                     /locus_tag="IE248_RS31350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63830"
                     /product="S41 family peptidase"
                     /protein_id="WP_190032415.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 1.8e-23, bitscore:
                     76.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPTKLAPAPVIDEMARLLTEHYVFPEIAEQLVDLLQQRLIEGA
                     YDVDDAEELGRLVTADLQSVNGDRHLRLKHHADPVSPKRGAATLDAMRRDFDASLGGAP
                     RVQLLDGGVAVVELAPMLFPLEWAAEPLGAALTLASRAEALIVDLRANRGGDPDTVAFV
                     CSYLLDERTHLNTMYWRGGERSEQSWSLPHVPGARFGGSKPLYVLSSESTFSASEELAY
                     DLQQLGRAVVVGEPTRGGAHPCQGWTLHPHLEATVPVGRAINPVSGTNWEGTGVQPDVP
                     CAAADSLDRAHALALTRLAG"
     gene            4571..5131
                     /locus_tag="IE248_RS31355"
                     /old_locus_tag="GCM10010336_63840"
     CDS             4571..5131
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530430.1"
                     /locus_tag="IE248_RS31355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63840"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190032416.1"
                     /transl_table=11
                     /translation="MRDQPPCSPPPGSPPPEDVLEIVAPEQFAALAHPLRQRLLFALGH
                     RPATTSQLAAQLDAKKGNVAHHLKVLREAGLVHIAETRQVRGGTEQYYQRTARQMVVAE
                     PQAAGTAAMLAAVAQELDLSPAEPLLTLRHLRLSPGKARELGEALAQLVEGVDEAEEEP
                     EDQPVHGVLVALYQQAPPASPTW"
     gene            complement(5184..5726)
                     /locus_tag="IE248_RS31360"
                     /old_locus_tag="GCM10010336_63850"
     CDS             complement(5184..5726)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735208.1"
                     /locus_tag="IE248_RS31360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63850"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190032417.1"
                     /transl_table=11
                     /translation="MVTLETPRLILRRWREEDVAPMAAINADPEVMRWIRHGSVRDEQQ
                     TRSGIQAWESEWESQGFGLFAVEIRSTGELAGFTGLSVPAFLPEVLPAVEVGWRLGRSH
                     WGQGLATEAAAAAVRFGFEERGLERIVSITQVGNDASERIMTKLGMHPARETVNPTGGR
                     RVRVFELSSTQYVTTTR"
     misc_feature    5884..5896
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.84"
                     /tool="antismash"
     gene            complement(<6001..6366)
                     /locus_tag="IE248_RS31365"
                     /old_locus_tag="GCM10010336_63860"
                     /pseudo=""
     CDS             complement(<6001..6366)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132057.1"
                     /locus_tag="IE248_RS31365"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63860"
                     /product="MerR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRIGELASRAGVSVRSVRYYEEQGLLTSTRSPSGQRHYTDSEVER
                     VAFIQRMYTAGLSSRTIVELMPCIDSPSEETSDAALERMALERERLSAHIADLLRTRDT
                     LDALMATARAHQHRMRSA"
     gene            6484..7557
                     /locus_tag="IE248_RS31370"
                     /old_locus_tag="GCM10010336_63870"
     CDS             6484..7557
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118363.1"
                     /locus_tag="IE248_RS31370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63870"
                     /product="alkene reductase"
                     /protein_id="WP_073795612.1"
                     /transl_table=11
                     /translation="MTSLFTSYQLGGLTLPNRMVMAPMTRARAAAGGLATPSMATYYAQ
                     RATAGLIVSEGVQPSLIGQSNPGTPGLFTDEQVEAWRPVTAAVHANGGRIFAQLMHGGR
                     VSHPDTTGLQPVGPSAVPAVGDVFTPTGPQPAPMPRALSTTEVPEHARSYARAAQRAVE
                     ADFDGVELHGANGYLISQFLSSNANLRTDRYGGPIANRIRFVVEAVAATVEAVGGERTG
                     IRLSPGGTFWGVEESEVRDLYTALLTELAPLGLAYVHLEATAEEATLVALRRAWPGTLV
                     MNPVFPMGAKQTGRDDADHWLGLGADLISFGRAFLANPDLVERLRGGLPLTPVDEATYF
                     QGGDTGFLTYPAHQYAA"
     gene            complement(7763..8116)
                     /locus_tag="IE248_RS31375"
                     /old_locus_tag="GCM10010336_63880"
     CDS             complement(7763..8116)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715826.1"
                     /locus_tag="IE248_RS31375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63880"
                     /product="VOC family protein"
                     /protein_id="WP_229895659.1"
                     /transl_table=11
                     /translation="MMLIMAIDSVVARQRVEDLDAAVPFYEKLTGSTATRFAFAGVNLA
                     SVGPFLLFAGPDEAVQRVAGVAATLAVSNLDTAVEEAEAGGAEIVMPIQPTPNGRRAVL
                     RHPHGGVFEYVGP"
     misc_feature    complement(8093..8107)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 20.1"
                     /tool="antismash"
     misc_feature    8093..8108
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    8102..8117
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.69"
                     /tool="antismash"
     misc_feature    complement(8544..8558)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.48"
                     /tool="antismash"
     gene            8566..9015
                     /locus_tag="IE248_RS31380"
                     /old_locus_tag="GCM10010336_63900"
     CDS             8566..9015
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039485.4"
                     /locus_tag="IE248_RS31380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63900"
                     /product="YidB family protein"
                     /protein_id="WP_190032524.1"
                     /transl_table=11
                     /translation="MTNEDGANQQPTSLTISSQSLAAAGLEPQVRSWIGDGPNEAITAG
                     QIVAAVGEDRLAQAAESLGWEPEDLAADLASRLPELVDSAVPDGQSASDTGGGFPGFQV
                     RWAPVPVQDLTSDLQIHPGIAPASSLTLNDEVAIDGSVTLTVRYL"
     gene            9387..9824
                     /locus_tag="IE248_RS31385"
                     /old_locus_tag="GCM10010336_63910"
     CDS             9387..9824
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018543.5"
                     /locus_tag="IE248_RS31385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63910"
                     /product="phage tail protein"
                     /protein_id="WP_190032419.1"
                     /transl_table=11
                     /translation="MEDNVVKHQWQIELGERRVETLKSVSGISFKQEYIQLLQNSPDGK
                     PVPDLVLGAPEFFGTLTLTRGLDKSERFTQWISESRDPAKAESSSQTIVLAYVNERNEV
                     VRRFQFEGARPSSWSAPDLSAGDSSAVEETLELTYVSANPI"
     gene            10001..11008
                     /locus_tag="IE248_RS31390"
                     /old_locus_tag="GCM10010336_63920"
     CDS             10001..11008
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735191.1"
                     /locus_tag="IE248_RS31390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63920"
                     /product="terpene cyclase"
                     /protein_id="WP_190032420.1"
                     /sec_met_domain="T1TS (E-value: 9.4e-81, bitscore: 265.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDFEFDLPFPLALSPDLEGARRRNLEWVQRTGLVGDGRSLQWY
                     ASWDMPRLAAYGFPYAQGPSLDLCTDAMAFFFVFDDQFDGPLGRDPARAAAVCQQLIDI
                     VHGAAPPQDADACSVAFADLWARSLAGAPPGWVARTAHEWEYYLATQAHEAIGRLRGTP
                     ADMETYLQVRRGIAGTDLPLSLGERAAGIHVPEAAFHSPQLRIMRQAAIDVTFMCNDVY
                     SLEKEEARGDMDNLVLVLQHTRTCTRDQALTAARGEVDQRVDRFRELAPQVPALCLQLG
                     LAGPERAAVDTYVEIMGAWMSGYHAWQTQTRRYTTAPVLLPSTGPGYFDEILPL"
     gene            complement(11089..11997)
                     /locus_tag="IE248_RS31395"
                     /old_locus_tag="GCM10010336_63930"
     CDS             complement(11089..11997)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044356.1"
                     /locus_tag="IE248_RS31395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63930"
                     /product="aldo/keto reductase"
                     /protein_id="WP_190032421.1"
                     /transl_table=11
                     /translation="MTSQTITAAASGTWKLGDRTVNRIGFGAMRLPQHGEAFAADAVPR
                     DRDQAIGVLRRAVELGVNHIDTAEFYFSPLRSANELINQALAPYPDDLVITTKVGPGRA
                     PSGQWLPHATPGQLRGQVEENLRRLGRDHLDVVNLRIVGTGSIAERFGALAELREAGLI
                     RHLGLSNVRPHHLVEAESIAPVVCVQNMYGLGASREQRDFLRICGEQHIAFVPFYSIAG
                     TGRTAGATTGHSPEVHAVARAHGVSAAQIRLAWTLHQGPHVLAIPGTGDLDHLAQNVAV
                     GSLRLSEEELAVLDPLHHKTA"
     gene            12068..13063
                     /locus_tag="IE248_RS31400"
                     /old_locus_tag="GCM10010336_63940"
     CDS             12068..13063
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546090.1"
                     /locus_tag="IE248_RS31400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63940"
                     /product="DUF5937 family protein"
                     /protein_id="WP_229895676.1"
                     /transl_table=11
                     /translation="MVLAELAFSTSDLAQVRFAVSPMWEVAPSFRLLRSGTTHPVHRPW
                     ADQVRPRMLAAGLDQGWLRELIPPTGGYVPDFLNPPPAGPAPTPAAERDAIRASPADRV
                     RRDLDHLARHQGDLGPRLRALHNDPQGLLAKVTDELETYWELALAPYWARIRAVLDADV
                     LYRARMAAEHGAGHLLNDLHTSLSWDGSALRMARRKQPLTRTTAGTGLLLIPSAFTGPG
                     LRTRTTPADPPQLAYPARGTGTLWEPRPATRADSLCAVLGRSRTLLLTELDMPASTTQL
                     AHRTGLSPAGVSQYLTALRNAGLVSAHRAGRSVLYARTAAAETLLQAASA"
     gene            complement(13117..14541)
                     /locus_tag="IE248_RS31405"
                     /old_locus_tag="GCM10010336_63950"
     CDS             complement(13117..14541)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007830815.1"
                     /locus_tag="IE248_RS31405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63950"
                     /product="MFS transporter"
                     /protein_id="WP_229895677.1"
                     /transl_table=11
                     /translation="MITAEIMDLLDASIVNVAGPDLEKSLGAGPVGLQWVIGGYALTLG
                     AGLVLGGRLGDRYGRRRMFLIGLAAFTASSLLCAIAPNIESLIAFRLLQGTAGAMLLPQ
                     GLGLLRENFSGPELTRVFAIFGPVLGLGGIIGPVLGGFLIEGDFFGLGWRSVFLINLPI
                     GIAALIVAAKFVPDRAGSRTVRVDITGATLIVASCALLVLPLNQGQEDGWPLWTWLSMA
                     ASAIGFALFALQQRRTAAAGREPLVAPALLRKPAFTVGLGGIALFFGGLIGTQLVLTLY
                     LQIGRQFTAGEAGLGNLPLAVGTAIGGAVSGAFLANRIGRGVLQIGPLGQLAGAAVLWF
                     ELDGLDSATFSIWDIVPGMTLAGIGAGMVIAALFSFILAAVDDHEIGSASGVLTAVQAV
                     GGSVGVAVFGSVFFDQAKAGDFTTGFHHALIVQAGLLMAFLAITFLLPKKSRPDDEQHG
                     ITPEASLDSDAEHLTV"
     misc_feature    14646..14663
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.95"
                     /tool="antismash"
     gene            14740..15270
                     /locus_tag="IE248_RS31410"
                     /old_locus_tag="GCM10010336_63960"
     CDS             14740..15270
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959275.1"
                     /locus_tag="IE248_RS31410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63960"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_190032422.1"
                     /transl_table=11
                     /translation="MEEAEAKRDDVAEQRERLTEALRVYGAHYTELGRRFAAWLGLHST
                     DAIAVLQITAAEERGTPLSPARLSERISLSTGATTALLNRLEAAGHITRAREHTDRRIV
                     TLRGGGHIQERAEEFFDPVAHRLDAAMSNYPPQLLDQFEAFMADLNTTLDTHLREQDSE
                     VPRSLNTPDGRTR"
     gene            complement(15300..15503)
                     /locus_tag="IE248_RS31415"
                     /old_locus_tag="GCM10010336_63970"
     CDS             complement(15300..15503)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735183.1"
                     /locus_tag="IE248_RS31415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63970"
                     /product="hypothetical protein"
                     /protein_id="WP_008735183.1"
                     /transl_table=11
                     /translation="MDETLDLLDTLLDGVSEPRLKLISADEGRALMVLLGLLDDAGLPE
                     DIRRAAGEMRSRLGSRLGVRLA"
     gene            complement(15560..16129)
                     /locus_tag="IE248_RS31420"
                     /old_locus_tag="GCM10010336_63980"
     CDS             complement(15560..16129)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS31420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_63980"
                     /product="hypothetical protein"
                     /protein_id="WP_190032423.1"
                     /transl_table=11
                     /translation="MKPLDSSTWDVALVRLLDDVYTFAMTGPRLHDDWAQDVLAVMHRV
                     VADPRGWRVMQWQIGKEWRENGHPSYPFLPLTAEEVREWTHPVTVGAAGELLASLAQEW
                     FFEPSPVRSRANRDEVLADARTVLGRFGPDAVFRTSSDLARTSDSPDFLAGELAGGRAF
                     TGYMMDLGLIAVSADEVGVFWSFNAL"
     gene            16937..17167
                     /locus_tag="IE248_RS31425"
                     /old_locus_tag="GCM10010336_63990"
     CDS             16937..17167
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735180.1"
                     /locus_tag="IE248_RS31425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_63990"
                     /product="chaplin"
                     /protein_id="WP_073795629.1"
                     /transl_table=11
                     /translation="MKKTTAVITATGAILLGAAGIASADAGAQGAAIGSPGVASGNLVQ
                     VPVHVPVNVCGNAISIVGLLNPAFGNTCVNA"
     gene            complement(17300..17524)
                     /locus_tag="IE248_RS31430"
                     /old_locus_tag="GCM10010336_64000"
     CDS             complement(17300..17524)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735179.1"
                     /locus_tag="IE248_RS31430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_64000"
                     /product="4-oxalocrotonate tautomerase family protein"
                     /protein_id="WP_190032424.1"
                     /transl_table=11
                     /translation="MPFANFKVPAGTLTAEQKEQIITRTTDLYAEIFGDRARATTLVLV
                     EEVADAGWGIGGGVLTLAKVGQVGQVAQN"
     gene            17692..18579
                     /locus_tag="IE248_RS31435"
                     /old_locus_tag="GCM10010336_64010"
     CDS             17692..18579
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126386.1"
                     /locus_tag="IE248_RS31435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_64010"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190032425.1"
                     /transl_table=11
                     /translation="MNLPELAAFLRSRRDRIRPADVGLPAGPRRRVPGLRREEVAQLAG
                     LSADYYTELERGRGAQPSSQTLAALARALRLGGDQRDHLFHLADRPLPASAHGVGARQV
                     QPALLGLLDRLATTPAQVITDLHETLLQNELAAALLGRAPEPRGPAAGFAYRWFTDPAA
                     RALYPPEDHPHHSRVFVADLQAVAARRGRDNEVAAMTAALRRRSAEFGALWDTYDVGLR
                     RTDHKRIVHPTLGVIELDCHSLFSEDGRQRLLWFTAPPGTEGAAQLELLGVIGTQDMSA
                     TEGASHTQGGVHAG"
     gene            complement(18631..19254)
                     /locus_tag="IE248_RS31440"
                     /old_locus_tag="GCM10010336_64020"
     CDS             complement(18631..19254)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735177.1"
                     /locus_tag="IE248_RS31440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_64020"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190032426.1"
                     /transl_table=11
                     /translation="MPKRVDHEERRTQIAEALIQVAGRRGLHAVGMRDVAAEAGVSLRL
                     VQYYFQTKERLLFHGVQHLTGRFTARVGARLAAAGPNPGPRATIEALLLASLPTDEESR
                     TFHLLYSSYSILSVTDEALAAQPFIDNPDAAENALTELLKQAQATGLADAHIDADTEAI
                     SLLAMTATMGTSILVGQRTPESAIAVLHHHLDRIFNGGQTPLPT"
     misc_feature    19346..19363
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    complement(19353..19367)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.77"
                     /tool="antismash"
     gene            19380..20330
                     /locus_tag="IE248_RS31445"
                     /old_locus_tag="GCM10010336_64030"
     CDS             19380..20330
                     /NRPS_PKS="Domain: Abhydrolase_1 (67-203). E-value:
                     2.2e-19. Score: 62.0. Matches aSDomain:
                     nrpspksdomains_IE248_RS31445_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092364.1"
                     /locus_tag="IE248_RS31445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_64030"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_073795635.1"
                     /sec_met_domain="PF00561 (E-value: 2.2e-16, bitscore: 53.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.6e-20, bitscore:
                     65.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPENTTRVRRDVGRYVNDKLRDRYFAAGDVLYAMGAPARSETDVE
                     TSFGTTHVYRYGPTDPAAESRTPIVLIHGAGYSSAMWYPNTPGLSLDRPVYALDTPGDA
                     GRSVHREPMWQPERAAQWMDEALDALGLDKVHVVGSSYGGWLVLNQAHRRPERLASVTA
                     LDPGGLEKVGLRFFAWVFISLFATFAPKALRPRLAKWLDQPVIAVPEMRKWIQLGARAY
                     RIRRPAPLPLAEDALRSIRTPLYVIMGKHSLLVHPKRQLERVPRLISGARAEIITATGH
                     GPQIDHPDVVNARMLSFMEDVDSLDPAPTRGAKGA"
     aSDomain        19581..19988
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS31445_Abhydrolase_1.1"
                     /evalue="2.20E-19"
                     /label="IE248_RS31445_Abhydrolase_1.1"
                     /locus_tag="IE248_RS31445"
                     /protein_end="203"
                     /protein_start="67"
                     /score="62.0"
                     /tool="antismash"
                     /translation="PIVLIHGAGYSSAMWYPNTPGLSLDRPVYALDTPGDAGRSVHREP
                     MWQPERAAQWMDEALDALGLDKVHVVGSSYGGWLVLNQAHRRPERLASVTALDPGGLEK
                     VGLRFFAWVFISLFATFAPKALRPRLAKWLDQ"
ORIGIN
        1 ccaggagacg cgcgtcgcgc ccgacgacgt agcgcgctcg tggccggcgg gccgtcaggc
       61 acgtctcgac ggtgcgtgcc accggctcag ggccgggcac ccgacggtcc acggacgcga
      121 acaggcgggc cgtggcctcg tatccgggac tgccggggcc gcggaacgcg tcgaggtcgg
      181 tcagagcacg gccgagcatg ggggtggcga acgcgccggg ctcgaccagg cagacgcgga
      241 caccgaggtg ggccgcctcc acgcgcaggc agtgcgtgag cgcggagagg gcgtgcttgc
      301 ccgcgctgta ccaggcgccc atcggccacg gaacacggcc cagacccgac gagatgttca
      361 cgatccggcc cccgccgcgg gcggccatgc ccggcaggac catccggcac agcctggccg
      421 gacccagcag attcacctcc agcagatacc gggcctgctc gtcaccgata tcggccaggg
      481 cacccgcccg cgggatgccg gcgttgttca ccagtgccca cggcccgcct ccggtcatct
      541 ccgagaccgt gcccagcgcc gtgtggcagg actgcgcgca cgccacgtcc aactgcacgg
      601 tgcgcagagc caggccacgc tcagcagcgt ccgcctccag ctgccgggcc ttgccctggt
      661 cgcgtgctcc ggcgatcaca tcccagcccg cgctcgccag acggaacacg atcacccggc
      721 cgaacccgcc cgtcgccccc gtcaccagca cactgcgccc gcccgacggc acgaccacgc
      781 cccacaccct tctcagccct gccctcatgc cgtagccacc cggccacgcc ccttacgggg
      841 gacaacgaca cctccccgtc gaagatgtgg tcccggggcg ccgggccaca cggcgggctc
      901 gtcatcggcg tccagctgtg ctcacttcgc cagacgtcgt acggccgtca ccacgctgcc
      961 cgcggcgtcc tccgttgaca tgtgccgcgc ggcggcggtg gccgccttcg cgtgagccgg
     1021 atcccgtacg gcggtgacga gcgcgtgggt gaggcggtcg gcggtcaggg accggaatgg
     1081 gatgggggcc ggtgccgcgc cgatcgcggc gagccgcgcg gcccagaagg gctggtcagc
     1141 ggcgatcggt accgtgacgg acgggatccc ggcgcgggct gccgccgccg tggtgccggc
     1201 tccggcgtgg tggacgacgg cggccagcca cgggaagagc gggccgtgcg gtacgtcgcc
     1261 gatggtcagg atgtcgtccc cgtccgcgac gagcccggcg ctgcccgact ggagcacccc
     1321 tcgcagcccg gctcgccgca gggcctgcac ggcgatctcg ctcaggcgtt ccccatggcc
     1381 ggcggccatg ctgccgaagc cgacgagcac cggtggcggt ccggccgcca ggaagttctc
     1441 cagctctgcg ggaagccggc ggcccgcgtc gaagtacggc caccaggagc cggtcaccgc
     1501 cagatgggcc ctccagtcgg acgggcgagg caccagcgct gtgctgaagc cgtgcaggac
     1561 gggccagccg gcccggtcct gccgccggcg catgcgtgtg gcggtgagcg gcggcagctg
     1621 aaggcgttcg cgtagtcgtg ccaccgccgg ctcatagacc cggtccgtca tgcgacgggc
     1681 gaagcgcccg gcggcgcggt tgccgaaccg gcccagcgag cgggctccca tgacggtcgg
     1741 ggcgaagtca ccggtcgggg cggtgggttg caggtacacg cccatgctcg gaatcccggt
     1801 cgcctcggtg acgtgccagc cgagcggggc ggtggtggcc gacagcagaa gcaggtccgt
     1861 gcccgcgtcc acggcatcgg cgaacccctc tcccaggccc gtgacgaacg cggcggcggc
     1921 ccgcagcagc gcgctcttgc cttggacgtc accgtgttcc cgggggtccg cgggcagcgg
     1981 ccggaactcc agccccgctt cttcggccag gggcgcgaac gactcggtgg cggcgagtgc
     2041 gacctcgtat ccggcgtccc gcaaggcggc acccagcccg gtgtagggcg cgacgtcacc
     2101 gcgtgatccg gccgtggcga tcaggattct catgggtgct cctcatatgc ggttctcgat
     2161 gtggatgcgg cgggacgcgt tggcgtgcac cgcttcggcc aggtaggcgg caagccccgg
     2221 gcgctgctgc gacggcggca cgacgagggc gaaggcgcgc gggtcggagg cgaagtcgtc
     2281 ggcgatccgc cggtgcatct ccggcgggca gggcgtgaac cagcgggaca cgtgcagccg
     2341 gtgctcctcc gcgatgtcca tgacccgttc gccgtcggcg ggttcgccgt cgtcgtggcc
     2401 cgcgagcagc tccgctcgcc aggcggcggc ctcggccatg agccggcgcc agtcctcctt
     2461 ggtgtgggcg gaggcccgcg ccatcgcctc ccggtgccct ttcgagtccc gccacttcag
     2521 ctgggcgtcg gtggcgtagc tgaggtcgaa cgcgatctcc ccgaatacct cgaagcgttc
     2581 ctcgggggtc agcggcaccc cggtctgctg gacctcgatc gcacgctcgg ccacctcggc
     2641 cagttgctgc agtcgcgtga tctcgtcggc cagttggcgc tgccgggtcc gcaggtgctc
     2701 cagcgcgttg gcttgcgggt cggcgaggat ctcggcgatc tcgtccaggg gaaagcccag
     2761 ttcgcggtag aagaggatct gctggagccg tgccaggtcg acgtcttcgt agtggcggta
     2821 cccggcccgg ctgcggccac ccggtgagag gagtccggtc ggtcgtagtg gtgcagtgtg
     2881 cgtacggtca ccccggcgaa ggccgagacc tgacccacgg tgtagcccat ggacctgccc
     2941 tttcgttcgg caacagcctc aagcctgacg tagggagagg gtcaacccgg gatcctgcga
     3001 cgcttcggac cctcgtcggc ggggaggtcg gtcgatccgc gagccggcag cccctcgtcc
     3061 tcggccgcga cgacgacgcc ggcggtggat acgtcagggg ccagatgctc gtgcgacggc
     3121 ggtcacagcg gggcggccgt acgcaccccc ggcaagggcg gcgagggtgg cgcgggtggc
     3181 ttcagctccg cacgcagcgg gaccaacggg acgggcccgg ggaccccgtg ccgtacggcg
     3241 aggaggtgta cacacccgtc ggcgccgacg gcaccggcgg gaacgtccag accagcgagc
     3301 tcctcgaccg acacccccgc ctacggacaa ggcggcgccg gaggggagag cggctacgga
     3361 gggaacggcg gtcccgtgcc cgatgacaag gacggaaagg ccggcggcga cggcgccgtg
     3421 aagttcaccc ggacttccgc caacacctga cggcctgcgg cacagttccc cccggccctg
     3481 ctcacccgcg cccgctcgcg gcgggcagac cagacaccct cacgctgcca ccagtggcag
     3541 aggagtccac gtcgccggcg cgggtgggga ggtgctgtgc gcagtgctgt cgatgagctg
     3601 gaccgggtca gcctgccagt cgggtgaggg ccagggcgtg tgcgcggtcg agggagtcgg
     3661 cggcggcgca ggggacgtcc ggctgcacac cggtgccctc ccagttcgtg ccggagacgg
     3721 ggttgatggc gcggccgacg gggacggtgg cttccaggtg cgggtgcagg gtccagccct
     3781 ggcacgggtg cgcgccgccg cgggtgggct cgccgactac cacggcgcgg ccgagctgct
     3841 ggaggtcgta tgccagttcc tcagaggcag agaaggtgct ctcgcttgac agcacgtaca
     3901 gcggcttgct gccgccgaag cgcgcgccgg gaacgtgcgg caggctccag gactgctcgc
     3961 tgcgctcgcc gccgcgccag tacatggtgt tgaggtgggt gcgctcgtcg agcaggtagc
     4021 tgcagacgaa cgcgacggtg tccgggtcgc cgccccggtt ggcccgcagg tccacgatca
     4081 gcgcctcggc gcgggaggcc agggtgagcg cggcgcccag cggctcggcg gcccactcca
     4141 gcgggaacag catcggtgcc agctccacca cggcgacccc tccgtcgagc aactgcaccc
     4201 ggggtgcgcc gcccagagag gcatcgaagt cccggcgcat ggcgtccagg gtggccgccc
     4261 cccgcttggg ggagaccggg tcggcgtggt gcttgagtct caggtgccgg tcgccgttga
     4321 cggactgcag gtccgcggtg accaggcggc cgagctcctc ggcgtcgtcg acgtcgtagg
     4381 cgccctcgat gaggcgttgt tgcagcaggt cgaccaactg ctcggctatc tcggggaaaa
     4441 cgtagtgctc ggtcagcagc cgggccatct cgtcgataac aggggctggt gcaagcttcg
     4501 ttggagtcgt catggctggg agtagagcac tgcccttgcg aaagcgtcaa agggtttgga
     4561 cactttagct atgcgtgatc agcctccctg ctcgccgcct ccaggttcgc cgcctcctga
     4621 ggacgtcctg gagatcgttg cgcctgagca attcgcggcg ctcgcccacc cgttgcgcca
     4681 gcggctgctc ttcgccctgg gccaccggcc tgccaccacc agccagctcg ccgcgcaact
     4741 cgacgcgaag aagggcaacg tggcccacca cctcaaggtg ctccgcgagg ccgggctggt
     4801 ccacatcgcc gagacgcgcc aggtccgcgg tggcaccgag cagtactacc agcgcacggc
     4861 ccgccagatg gtcgtcgccg aacctcaagc ggcaggcacc gccgcgatgc tggccgcggt
     4921 cgcccaggag ctggacctct cgcccgccga gcccctcctg acactgcgcc acctgcgtct
     4981 gagccccggg aaggcaagag aactcggcga ggccctcgcc caactggtcg agggggtcga
     5041 tgaggccgag gaggagccgg aagaccagcc cgtacatggc gtgttggtgg cgctctatca
     5101 gcaggctccg ccggccagcc ccacttggta gggcgggccc accggtcggc ccggatcctc
     5161 accgagtcct tccactgatg ccatcaacga gtggttgtga cgtactgggt cgacgacagc
     5221 tcgaacaccc gtactcgccg accgccggtg ggattgacgg tctcacgggc cggatgcatc
     5281 cccagtttgg tcatgatccg ttcggaggcg tcgttgccca cttgagtgat gctgacgatc
     5341 cgctccagcc ctcgctcttc gaagccgaac cgcacagcgg ccgcagcggc ttcggtggcc
     5401 aagccctgcc cccagtggga acgtcccagc cgccagccga cctcaaccgc cggcagtacc
     5461 tccggcagga aggcgggcac cgaaagcccg gtgaaaccgg ccagttcgcc agtggaccgg
     5521 atctccacgg cgaacagacc gaagccctgt gactcccact cgctctccca tgcctggata
     5581 ccactgcgag tctgctgttc gtcccggacg ctgccgtgac ggatccaccg catgacctcg
     5641 ggatcggcat tgatggcagc catgggcgca acgtcttcct cgcgccagcg acgcaggatc
     5701 aaacggggag tctcaagcgt gaccatccag tgattctgga tcacaacata ggcccaccgc
     5761 catcctcacc agccatcttc gacacacgcc cgcatggatc tcgtacaccc tctcgacggc
     5821 gggagggcgc gcgccactgc cgccggcccc acgcctgcgg ctcgcgcgct cacccggtag
     5881 gccgtgaacc tgtcaccacg gggttcgtac tccttgccca tcggaccgac cggatcgatc
     5941 agcagcggaa aggggctgcg gacggcagga agccgggggc tgccagtcag agtctgcacc
     6001 ggcggacctc atccggtgct ggtgcgcccg ggccgtggcc atcaacgcgt ccagggtgtc
     6061 tcgggtccgc aggaggtcgg cgatgtgcgc ggagagccgc tcacgctcca gtgccatccg
     6121 ctccagcgcg gcatcggagg tctcttcgct gggcgagtcg atgcagggca tcagctcgac
     6181 gatggtccgg ctggacaggc cagcggtgta catccgctgg atgaacgcga cccgttcgac
     6241 ctcactgtcc gtgtagtgcc gttgtccgct ggggctgcgg gtgctggtga gcagtccttg
     6301 ttcctcgtag tagcgcacgg accggacgct gactccggcg cgcgatgcga gctccccgat
     6361 ccgcatagga cctcctggcg aagttgagcg tcgtagaccc ttgcctctga cgtcgatgtc
     6421 aggttttagc gtagccgctg tgcccccgaa acgcgggcac ggcagttacg aaggagcccg
     6481 gacatgacga gtctgttcac cagttaccaa cttggcggtc tcaccctgcc caaccggatg
     6541 gtcatggccc cgatgacccg agcccgggcc gcggccggcg gcctggcgac cccttccatg
     6601 gcgacgtact acgcccagag ggccacggcc ggcctgatcg tgagcgaagg ggtgcagccg
     6661 agcctgatcg ggcagtccaa cccgggcaca cccggactgt tcaccgacga gcaggtcgag
     6721 gcgtggcgcc ccgtgaccgc cgccgtccac gccaacggag gacggatctt cgcccagctc
     6781 atgcacggcg gccgggtctc gcaccccgac accaccggcc tacagccggt cgggccctcg
     6841 gcggtccccg ccgtcggcga cgtcttcacc cccaccgggc cgcagcccgc cccgatgccg
     6901 cgcgccttga gcaccaccga agtacccgaa cacgcgcggt cctacgcccg ggccgcccag
     6961 cgcgccgtgg aggcggactt cgacggagtg gaactgcacg gtgccaacgg atacctgatc
     7021 tcccagttcc tgtcgtccaa cgccaatctg cgcaccgacc gctacggggg cccgatcgcc
     7081 aaccgcatca ggttcgtcgt cgaggccgtc gccgccaccg tcgaggccgt cggtggggag
     7141 aggaccggca tccggctctc accgggcggg acgttctggg gagtggagga gagcgaggtc
     7201 cgcgacctct acaccgcgtt gctgaccgaa ctggcaccgc tcggattggc atacgtgcac
     7261 ctcgaagcca ccgcggagga ggccacgctc gtcgccctgc gccgcgcgtg gccgggcacc
     7321 ctcgtgatga acccggtctt tccgatgggc gcgaagcaga caggtaggga cgacgccgac
     7381 cactggctcg gcctgggtgc cgacctcatc agcttcggcc gggccttcct cgccaacccc
     7441 gacctcgtcg agcggctacg gggcggactt cccctcaccc cggtcgacga ggcgacgtac
     7501 ttccagggcg gcgatacggg attcctgacc tatccggccc accagtacgc ggcttgatct
     7561 ccggctgggt cgctgcctca gcggagggcc gtggctgtgg tggtccggca tcgacgccag
     7621 cgttcgttcg ccgcttcgac gtggagcaca cctctcgccg cctgttcaag caggtgctcg
     7681 gctcgctgct cgggtccgag aaccacaccc gggccggcac gcggcgcggg atgaggcgac
     7741 gagctgaaca ccaaggcagg tgtcaggggc cgacgtactc gaagacgccg ccgtgcgggt
     7801 gccgcaggac tgcacggcgg ccgttcgggg tgggctgaat gggcatcacg atttcggctc
     7861 ctcccgcttc cgcctcctcg actgcggtgt ccaggttgga gacggcgaga gtcgccgcca
     7921 cgcccgcgac gcgctgcacc gcctcatcag gcccggcgaa cagaaggaaa ggcccgacgc
     7981 ttgccaggtt gaccccggca aaggcgaacc gcgttgcggt gcttccggtc aacttctcgt
     8041 agaagggcac agccgcatcg agatcctcga cacgctgtcg cgcgaccact gaatcgatag
     8101 ccatgatcag catcatcaca cctgcatacg cgcctgcgaa gggaattcct gcagacctgc
     8161 cagtcgcttg gtgcgccgag aatggtgacg tggcggggcc ggtgcgttcc gccgggcggc
     8221 tccggggatg gtgagggctc cttgccggga gccgttggcg tagtcggccg cccataaggg
     8281 cccgctggtg ccccgcatca gggtgctcag ggcgcccgtt gcctggttga cggcgagtgc
     8341 ggggccctgg ctgacgcgcc agttcggacg gcaccccggt cctgccacac ggcggatcga
     8401 ggtgtcgtgg agccgaaaac cgccgaaccg tgcacgtgcg gatggatgat ctgccttgga
     8461 ggcagcagca gctgccgtac gtgagccttg agaggtaccc gctccaaagg caggaacctc
     8521 gtatcgcgtg gatcagcgag agggattttc cgaatggatg actctgtgac caacgaagac
     8581 ggtgcgaacc agcagccgac gtccttgacg atctcgtcgc agagcctggc cgctgccggc
     8641 ctggagccgc aggtgcggtc gtggatcggc gacggcccca acgaggcgat caccgccggc
     8701 cagatcgtcg cggctgtcgg tgaggaccgg ctcgcccagg ccgccgagag cctgggatgg
     8761 gagcccgagg acctggccgc cgatctcgcc tcccgactcc ccgaactcgt cgacagcgcg
     8821 gtgcccgacg gccagagcgc ttcggacacc ggaggcgggt tccccggttt ccaggtccgc
     8881 tgggccccgg tccctgtcca agacctcacc tcggacctgc aaatccatcc cgggatcgcg
     8941 ccggccagca gcctgactct gaatgatgag gtggcgatcg acggctcggt gaccctcacc
     9001 gtcaggtacc tctgagcgac tccggcaacc cggcgggacc gcgctctggg ggcggcagta
     9061 ccaccgggcc gccccaacgt caccggcccc cggccggcct tgcatgtggc gcggaccagc
     9121 tacggaaaaa gccggctcgc gcaggtctcc ggcttgccac tgacaacgtg gggggcaggg
     9181 ctcggcagtc ccgcacgtgc ccgcgctctg cgcggacggc acgggcccgg gggcgccgga
     9241 gaggacgagg gaggaagggc tgccaggacc tgtccgggcg gtcaagcgcg cggatgcgga
     9301 agcgtgcagg tatcgatcaa gcatggatgg gcatgatcac cgggctgttg gattgccctt
     9361 cgtgggccca cggagacgga gtgttcatgg aagacaatgt cgtcaagcac cagtggcaga
     9421 tcgagctggg ggagcgtcgg gtggagacgc tcaagagcgt ctccgggatc tcgttcaaac
     9481 aggagtacat ccagctgctg cagaactcgc cggacggaaa gccggtcccc gaccttgtcc
     9541 tgggcgcacc ggagttcttc gggacgctga ccctcacgcg gggcctggac aagagcgaga
     9601 ggttcactca gtggatctcg gaatccaggg atccggccaa ggcggaatcc agttcccaga
     9661 ccatcgtcct ggcctacgtg aacgagcgga acgaggtcgt gaggcgcttt cagttcgagg
     9721 gcgcccgacc ttcgagctgg agcgccccgg acctgtcggc gggcgactcc tcggcggtgg
     9781 aagaaacgct cgaactcacc tatgtgagcg ccaacccgat ctaaagcctt ctgggccgtt
     9841 gatgtggaca tggggtgggg cgatctgaat gataccgagt gggaacggct ggggccgttc
     9901 ccgccggtca gtaactccgg tcagcgcctg accgtgcgct cggtatcgga agaagccggc
     9961 gagcccatcc ggctgtgccc cgcacttccc cggaggacac atgccgcagg acttcgagtt
    10021 cgacctgccc ttccccctcg ccctcagccc cgacttggag ggcgcgcggc gccggaatct
    10081 ggaatgggtg caacgtacgg gcctggtcgg ggatggcaga tcgcttcagt ggtacgcctc
    10141 atgggacatg ccccgcctgg ccgcctacgg ctttccctac gcccaagggc cgtcgctgga
    10201 tctgtgcacg gacgccatgg cgttcttctt cgtcttcgac gaccagttcg acggccccct
    10261 cgggcgggat cccgccaggg ccgcggctgt ctgtcagcag ctgatcgaca tcgtccacgg
    10321 tgccgccccg ccccaggacg ccgacgcgtg ctcggtggcg ttcgccgatc tctgggcccg
    10381 cagcctcgcc ggcgcccctc ccggctgggt ggcccgtacc gcccacgagt gggagtacta
    10441 cctcgccacc caggcccacg aggcgatcgg ccgcctgcgc ggcacccccg ccgacatgga
    10501 aacctacctc caggtccgca ggggcatcgc cggaaccgat ctgcccctgt ccctcggcga
    10561 acgcgcagcg ggcatccacg tacccgaggc cgccttccac agcccgcagc tgcgcatcat
    10621 gcgccaggcc gccatcgacg tcaccttcat gtgcaacgac gtctactcgc tggagaagga
    10681 agaagcccgc ggcgacatgg acaacctggt cctggtcctc cagcacaccc ggacgtgcac
    10741 ccgagaccaa gccctcaccg ccgcacgcgg ggaagtcgac cagcgcgtcg accgcttccg
    10801 ggaactcgcc ccccaggtac ccgcgctgtg cctccagctc ggcctcgccg gcccggaacg
    10861 agccgcggtg gacacgtatg tggagatcat gggggcctgg atgagcggct accacgcctg
    10921 gcagacccag acccgccgct acaccaccgc cccggtcctg ctgcccagca ccgggcccgg
    10981 ctacttcgac gagatcctgc cgctgtgacg accacgcagg cgcttgtagg gcgcgcccgg
    11041 aggcagtcga gacgtaagaa gtggaccacg gcgcgacggg ggtcctgttc atgccgtctt
    11101 gtggtggagg gggtccagga cggcgagttc ttcctccgac aggcgtaggg agccgacggc
    11161 cacgttctgg gcgaggtggt cgaggtcgcc ggtgccgggg atggccagta cgtgggggcc
    11221 ctggtggagt gtccacgcca gccggatctg ggccgcgctc acaccgtggg cgcgggcgac
    11281 ggcgtgcacc tccgggctgt ggccggtggt cgcgccggcg gtgcgcccgg tgccggcgat
    11341 cgagtagaac ggcacgaacg cgatgtgttg ttcaccgcag atgcgcagga agtccctctg
    11401 ctcgcgcgat gcgccgagac cgtacatgtt ctggacacag accaccggtg cgatgctctc
    11461 ggcctcgacg aggtggtggg ggcggacgtt ggacaggccc aggtgacgga tgagtccggc
    11521 ctcgcgcagt tcggcgagcg cgccgaagcg ttcggcgatg gagccggtgc cgactatgcg
    11581 caggttcacc acgtcgaggt ggtcgcggcc gagccggcgc aggttctcct cgacctggcc
    11641 gcgcagttgc ccgggggtgg catgcggcag ccactggccg gagggggcgc ggcccggccc
    11701 gaccttggtg gtgatgacga ggtcgtccgg gtagggggcc agcgcctggt tgatcagctc
    11761 attggcggag cgcaacggtg agaagtagaa ctcggcggtg tcgatgtggt tcacgccgag
    11821 ctcgaccgcg cggcgcagca cgccgatcgc ctggtcgcgg tcgcgcggga cggcatcggc
    11881 cgcgaaggcc tcgccgtgct ggggcaggcg catcgcgccg aatccgatgc ggttgaccgt
    11941 gcggtcgccg agcttccagg tgcccgatgc cgccgcggtg atcgtctgtg aggtcatggc
    12001 gggatgatct ccgcacggta ggctggcccg ccaatgattc agacatgcct gaatccattg
    12061 aggagtgatt gtcctggcag agctggcgtt ctcgacgagc gatctggcgc aggtgcggtt
    12121 cgccgtctca ccgatgtggg aggtcgcacc cagttttcgg ctgctcaggt ccggcaccac
    12181 gcatccggtc caccggccat gggccgacca ggtacgcccg cgcatgctgg ccgccgggct
    12241 ggaccagggc tggctccgcg agctgatccc gcccaccggc ggctacgttc ccgacttcct
    12301 caacccgccc cccgccggac ccgcccccac cccggcggcg gagcgggacg cgatccgggc
    12361 ctcgcccgcc gaccgggtac gccgggacct cgaccacctc gcccgacacc aaggtgacct
    12421 gggcccccgg ctgcgggcac tgcacaacga cccacagggg ctcctggcca aggtcacaga
    12481 cgagctcgaa acgtactggg agctggcact cgccccctac tgggcacgca tccgggcagt
    12541 cctggacgca gacgtcctct accgggcccg catggccgcc gagcacggcg ccggccacct
    12601 cctcaacgac ctgcacacgt ccttgagctg ggacggcagc gcgctacgga tggcccgccg
    12661 aaagcagccg ctgacccgta cgacggcagg aacaggactg ctgctgatcc cctcggcctt
    12721 caccggaccg ggactgcgca cccgaacgac gccggcggac ccaccccaac tcgcctatcc
    12781 ggcgcgcggt accggcacgc tgtgggagcc gcgccccgca acccgggccg actccctctg
    12841 cgccgtactg gggcgctcac ggactctact gctgaccgag ttggacatgc cggcctccac
    12901 cacacagctg gcccaccgca ccgggctctc tcccgcaggg gtatcccagt acctgaccgc
    12961 gctgcgcaac gcgggcctgg tcagcgcgca ccgcgccggc cgctccgtcc tctacgcccg
    13021 caccgccgcg gccgagaccc tccttcaagc cgcctccgcc tgacctcacg tcacccccga
    13081 aggagctacg gagccgaccc acctcccggc gcggtgtcag acggtgaggt gttctgcgtc
    13141 ggagtcgagg gaggcctcgg gggtgatgcc gtgctgctcg tcgtcggggc gggacttctt
    13201 gggcaggagg aaggtgatgg cgaggaatgc catgagcagg cctgcctgaa cgatcagcgc
    13261 gtggtggaag ccggtggtga agtcaccggc cttggcctgg tcgaagaaga ccgagccgaa
    13321 gaccgcgacg ccaacggagc cgccgacggc ctggaccgcg gtcaggactc cggacgcgga
    13381 gccgatctcg tggtcgtcga cggcggcgag aatgaagctg aacagggcgg cgatcaccat
    13441 gccggcgccg atgcccgcga gcgtcatgcc gggaacgatg tcccagatcg agaaggtggc
    13501 ggagtcgagg ccgtcgagtt cgaaccacag cacggccgca ccggcgagct ggcccagcgg
    13561 tccgatctgg agcacgccgc ggccgatcct gttcgcgagg aaggcgccgc tgacggcgcc
    13621 gccgatggcg gtgcccaccg cgaggggcag gttgccgagc cccgcctccc cggcggtgaa
    13681 ctggcggccg atctggaggt agagggtcag gacgagctgg gtgccgatca gcccgccgaa
    13741 gaacagggcg atgccgccga gcccgacggt gaaggcgggc ttgcggagca gggcgggggc
    13801 caccagcggt tcgcggcccg cggcggccgt tcgtcgctgc tgaagggcga acagggcgaa
    13861 gccgatcgcg gaggcggcca tgctgagcca cgtccacagc ggccagccgt cctcttggcc
    13921 ctggttcagg ggcagcacga gcagggcgca cgaggccacg atcagggtcg cgccggtgat
    13981 gtcgacccgt accgtgcggc tgcccgccct gtcgggtacg aacttcgcgg cgacgatcag
    14041 ggccgcgatg ccgatcggca ggttgatcag gaacaccgac cgccagccca ggccgaagaa
    14101 gtcgccctcg atgaggaagc cgcccaaaac cgggccgatg atgccgccga ggcccaggac
    14161 gggcccgaag atcgcgaaga ctctggtgag ctcggggccg gagaagttct cccgcagcag
    14221 gcccaggccc tggggcagca gcatcgcccc ggcggtgccc tgcagcagac ggaaggcgat
    14281 cagcgactcg atgttcggcg cgatcgcgca cagcagtgag ctcgcggtga aggcggccag
    14341 gccgatcagg aacatccggc gtcggccgta ccggtcgccg agccggcctc cgaggaccag
    14401 accggcgccc agggtgaggg cgtaaccgcc gatgacccat tgcagtccta cggggccggc
    14461 gccgagggat ttctccaggt ccgggccggc gacgttgacg atcgaggcgt ccaggaggtc
    14521 catgatctcg gccgtgatca tgaccgccag gatcagccac ctccatcgga tcggctcggc
    14581 ggtggtgtcg ggggtgggtt cggggatggg ggagggggcg gacacgagta gatacctcca
    14641 tggtgaagta attccatcgt gaaggtaaaa tggtgggggt aggttgtcaa cctggaatgc
    14701 cgatgtgacc gcgctgcgga cgacaagggt ggaggtcccg tggaagaggc agaggccaag
    14761 cgcgacgatg tcgcggaaca gcgcgagcgg ctgacggaag cgctgagggt ctacggcgcc
    14821 cactacacag agctcggccg ccgcttcgcc gcctggctcg gcctgcactc caccgacgcc
    14881 atcgcggtgc tccagatcac cgccgccgag gagcgcggaa cccccctgtc accggcacgg
    14941 ctcagcgagc ggatctccct gtccacggga gcgaccaccg cactgctgaa ccgcctcgaa
    15001 gccgccggac acatcacccg cgcccgcgag cacaccgacc ggcgcatcgt caccctgcgc
    15061 ggcggaggac acatccagga acgagcggag gagttcttcg acccggtcgc ccaccgcctc
    15121 gacgcggcga tgtcgaacta cccgccccag ctcctggacc agttcgaagc gttcatggcc
    15181 gacctgaaca ccaccctgga cacccacctc agggaacagg actcggaagt tccgcgctcc
    15241 ctcaacaccc ctgatggccg gacccgctga cctgcgtgct gttgctttcg ccccgtcgtt
    15301 caggcgaggc ggacaccgag acgggagccg agccgggatc gcatctcgcc ggcggcccgg
    15361 cggatgtcct cgggcagccc ggcgtcgtcg aggagcccga ggagcaccat caacgcccgc
    15421 ccttcgtcgg cgctgatcag tttcaggcgt ggctcgctca ctccatcgag caaggtgtcg
    15481 agcagatcga gagtctcgtc catgcaggaa tcaacgctcg cccacgcccg tacgtcacca
    15541 tggccggacg cggcgctgct cagagcgcgt tgaacgacca gaagaccccg acctcgtccg
    15601 cgctcaccgc gatcaggccg aggtccatca tgtagccggt gaaggcgcgg ccgccggcga
    15661 gttcaccggc caggaagtcc ggcgagtcgg aggtccgggc caggtcggag gaggtccgga
    15721 agacggcgtc gggaccgaac cggccgagca ccgtccgcgc gtcggccagc acctcgtccc
    15781 ggttcgcccg agaccggaca ggggagggct cgaagaacca ctcctgggcc agcgaggcga
    15841 gcagctcacc ggcggcgccg accgtgacgg ggtgggtcca ctcacgcacc tcctcggccg
    15901 taagaggcag gaacgggtag gaagggtggc cgttctcgcg ccactccttg ccgatctgcc
    15961 actgcatcac ccgccagccc cgggggtcgg cgaccacccg gtgcatgacg gccaggacgt
    16021 cttgtgccca gtcgtcgtgc agacgtggcc cggtcatcgc gaaggtgtag acgtcgtcga
    16081 ggaggcgcac caacgcgacg tcccaggtac tgctgtcgag gggcttcatc tgacttccgg
    16141 ttcggtcggt catggagcgg gcgcgggtgt ccccgcccgc gatgggagtc gagggatcag
    16201 tcgcctccgc cgccaccgca agaggagccg ccaccacagg aggagtctcc gctgccggac
    16261 gcaccgtccc cgcaggagaa actgacgccg tcgttcttcc atgaccggga gcgtccctgg
    16321 ggctgcgatg acctgccgcc gaacgcgccg ccgcgccaga gctggaagag cccccaggcg
    16381 agaccgattc ccgcggctat caggtattcc atgtccgttg cccctgttcc tttccattct
    16441 cgcctgtgcg gggccgccgg tctccgcgac gaggcggcag gccgtctcac ggcgctgcca
    16501 ccagtgccgc cggaacgacg tacggcaggg ccggccacgc cgtggcagcc aagggggccg
    16561 gcggggcgag gagccatgcg gctggaggct tcggggggga agtcgcgttc atgggcccat
    16621 tgcaccggcc cgggcccccg tgcgcatggg tgcacgtact cagacgacct ggtccgtgta
    16681 cccagcaaac acagtgcttc ggggcacgat ctctcaaccg cagaccttgg cgtcggctgt
    16741 cgtgcggggc ccggctgggc agccaaccgg gccccgctcg tggtcgcggg gcacccgaac
    16801 gggtcgatca ccgtgtccgt ttaccccatt gaccagttgg agaggacaag cgcccggcat
    16861 gggcctggct gtccggccta cggccgccgc cgcttgatct cgtacaccgt ttgaagcaca
    16921 tcctgaagga gaccctgtga agaagaccac ggccgttatc accgccaccg gcgccatcct
    16981 gctcggcgcg gcgggcatcg cctccgccga tgccggcgcc cagggtgcgg ccatcggatc
    17041 gccgggtgtc gcctccggga acctcgtcca ggtcccggtc cacgttcccg tcaacgtctg
    17101 cggcaacgcc atcagcatcg tcgggctgct caacccggct ttcggcaaca cctgcgtcaa
    17161 cgcctgatca ggccccagca gcgcaccggg ggccttgccg gtttccccgt gtgacacgtg
    17221 agcgtggccc cggattcctc cccggtcggc cgcgctcacg cgcgtttcca ccccgccgcc
    17281 gcgggacgac aggccgccct cagttctgcg cgacctgccc gacctgcccg accttggcga
    17341 gcgtcaggac tccaccgccg atgccccatc cggcgtcggc gacctcctcc accagtacga
    17401 gggtggtggc ccgggcgcgg tcgccgaaga tttcggcgta gaggtcggtg gtacgcgtga
    17461 tgatctgctc cttctgttct gcggtgaggg tgccggcggg gaccttgaag ttcgcgaatg
    17521 gcatggtgat ctctcttcgt acgcggggtg ccggagctgc tcacgacgag caggaggtcg
    17581 accccgatgg ggcaaccatc cgtccgagtt gcctgctcgg gccagggctg agcccaccca
    17641 ggggtcatca gcccctggct cggaccccgc cggagaggcg acgatgagcg ggtgaacctt
    17701 cccgaacttg cggcgttcct cagatcccgg cgtgatcgga tccggcctgc cgacgtgggc
    17761 ctgcccgccg ggccccggcg gcgggtgccg gggctgcggc gtgaggaggt cgcgcaactg
    17821 gcgggcctgt cagccgacta ctacaccgag ctggagcgcg gccggggcgc tcagccgtcg
    17881 tcccagactc tggccgccct cgcccgggcg ctgcggctgg gtggcgatca gcgtgaccac
    17941 ctcttccatc tcgccgaccg gccgctgccc gcatcggcgc acggcgtagg cgcgcggcag
    18001 gtccagcccg ccctgctcgg gctgctggac cggctggcca cgactccggc ccaggtcatc
    18061 accgacctgc acgagaccct cctccagaac gagctggccg cggcactgct cggccgtgct
    18121 ccggagccgc gggggcccgc cgccggcttc gcgtaccgct ggttcaccga tcccgccgcc
    18181 cgcgcgctct atccgcccga ggaccacccg caccactcac gggtcttcgt cgccgaccta
    18241 caggcagttg ccgcccgccg cggccgcgac aacgaggtcg ccgcgatgac tgccgccctg
    18301 cgacggcgca gcgcggagtt cggcgccctg tgggacacct acgacgtcgg cctgcgccgc
    18361 accgatcaca aacgcatcgt ccaccccacg ctgggcgtca tcgagttgga ctgtcacagc
    18421 ctgttcagcg aggacggccg ccagcgcctg ctgtggttca cggccccgcc cggcaccgag
    18481 ggcgccgctc agcttgagct gctcggcgtc atcggcacgc aggacatgtc cgcgaccgag
    18541 ggcgcctctc acacccaggg cggcgtacac gcgggctgag agcggagaga gccccggcgc
    18601 cagagccggt gtccggcggc gccgtcggaa tcacgtgggt agcggggtct ggccgccgtt
    18661 gaagattcgg tcgaggtggt ggtggagtac cgcgatggcc gactccggcg tccgctggcc
    18721 gacgaggatg ctggtgccca tggtcgcggt catggcgagc aggctgatcg cctccgtgtc
    18781 cgcgtcgatg tgggcatcgg ccaggccggt cgcctgtgcc tgcttgagca gttcggtcag
    18841 ggcgttctcg gcggcgtcgg ggttgtcgat gaagggctgg gcggcgagtg cctcgtcggt
    18901 gacggagagg atggagtagg agctgtagag gaggtggaag gtccggctct cctcgtcggt
    18961 ggggagggag gccaggagca gcgcctcgat ggtcgctcgt ggacccgggt tcggtccggc
    19021 ggcggcgagg cgggcgccca cgcgcgcggt gaagcggccg gtcaggtgct ggacgccgtg
    19081 gaagagcagt ctctccttgg tctggaagta gtactggacg agccgcaggg atacacccgc
    19141 ctcggctgcg acgtcgcgca tgccgacggc gtgcagtccg cgccgcccgg cgacctggat
    19201 gagtgcctcg gcgatctggg tgcgccgttc ctcgtggtcc acgcgcttcg gcatgtgccg
    19261 tgcctccgcc tgtcggtggt gagttcgtgt ccggccgttc cggacgcctt catggtaccg
    19321 ctgtaccaac aacatggtac ggtcgtatca cgaagaacgg atcttcctgg aggtgccccg
    19381 tgcccgagaa cacgacccga gtgcgccgcg acgtcggccg ctacgtcaac gacaaactcc
    19441 gcgaccgcta cttcgccgcg ggcgatgtgc tctacgcgat gggagcaccc gcacgctccg
    19501 agacggatgt cgagacgagc ttcggcacca cccacgtcta ccggtacggc cccaccgacc
    19561 ccgcagccga atcccgtacc cccatcgtcc tgatccacgg cgccggctac agctcggcca
    19621 tgtggtaccc caacaccccc gggctcagcc tcgaccgccc cgtctacgcg ctcgacaccc
    19681 ccggtgacgc gggccgcagc gtccaccgcg agcccatgtg gcagcccgag cgcgccgcgc
    19741 agtggatgga cgaagccctc gacgcgctcg gcctcgacaa ggtccacgtc gtcggctcct
    19801 cctacggcgg ctggctcgtc ctcaaccagg cccaccgccg gcccgaacga ctcgcctccg
    19861 tcaccgcgct cgaccccggc ggcctggaga aggtcggcct gcgcttcttc gcctgggtct
    19921 tcatcagcct cttcgccacc ttcgccccca aggccctgcg cccccggctc gccaagtggc
    19981 tggaccagcc ggtcatcgcc gtccccgaga tgcgcaagtg gatccaactc ggcgcccgcg
    20041 cataccgaat ccgccgcccc gcacccctgc cgctcgccga ggacgcgctg cggtccatcc
    20101 ggaccccgct ctacgtcatc atgggcaagc acagcctgct cgtacacccg aagcggcagc
    20161 tggagcgcgt accgcgcctg atatccgggg cccgcgccga gatcatcacc gcgaccgggc
    20221 acggcccgca gatcgaccac ccggacgtgg tcaacgcccg gatgctgtcc ttcatggagg
    20281 acgtcgactc cctcgacccg gcgccgaccc ggggcgccaa gggcgcgtag tagtgaggcc
    20341 gccgaaagtt cagtgcatcg tggatcctgc ggcgtcgcac tgagagccgg aaggcctgga
    20401 cggtcggatg gcggtgggct acgcgggcct gccaggggcg gtgactcgcc gcccccgggg
    20461 agcacggcgg gtatggagcc tgctccgttg gcgcacgatc aggagcgggc cccgaagggg
    20521 aagaaataca catacgcatg gccgctgaag ctggtcgtaa tctccacgcg ccagcccttc
    20581 cggaccgggt gcgggacctc ctcgttcgtg tcgatgacag ggacccattg gccggagtca
    20641 ttggttcgga gaatgcggtg gctggtacct gtgtgctcca tgcgggcaat tccgtcgcag
    20701 gggaagtcat aggtccaggg agtgccgggc ttgatgctgc tggtgtattc gaggtgcagt
    20761 tcactgaaca gcttcagcgc tttgccctgg gataggtcga cggggccgtg ggcggcgagg
    20821 agtccgttga ggaccgtgtc cccgtggacg gtgaggctgc cgacttccag gtcgggtcgc
    20881 aggacggtta cctgggtgct gaggatgcgg acgacggggt tggtggggtc gcccgtggtg
    20941 gcgcggaggt agaaggtggt gtcggatttg atgccttcga tgtcgaggct ggtgcggttg
    21001 gtgacgtc
//
