LOCUS       NZ_BMVE01000013        24631 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence13, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000013
VERSION     NZ_BMVE01000013.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 257139)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 11448
            Orig. end                         :: 36079
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24631
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24631
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24631
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14631](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14631)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    351..366
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.78"
                     /tool="antismash"
     misc_feature    704..717
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(851..867)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            complement(872..1588)
                     /locus_tag="IE248_RS37710"
                     /old_locus_tag="GCM10010336_59000"
     CDS             complement(872..1588)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013964.5"
                     /locus_tag="IE248_RS37710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59000"
                     /product="HNH endonuclease"
                     /protein_id="WP_229895599.1"
                     /transl_table=11
                     /translation="MGDTQEAAGERLLQTLRSMKAYDPAGDYYALTLGANRRGGLVSAD
                     ALGGLLRAEPALGDPRRVPRRPRIHPQGLDRRNALVGRQVAEDRLSSVIAPKECVHDGS
                     AESGGFGYLVTQHLPDDAVERRAPTRKLRMQVLKRDGFRCVVCGRRASDHTDIELHLHH
                     LVPWRMAGPTAEENLVTLCGTCHKGLDPDFEPALRELAGLPGPAAGLDMDNAEFDEEVT
                     RCRALAGEVLAQRQVP"
     tRNA            complement(1671..1743)
                     /anticodon=(pos:complement(13156..13158),aa:Arg,seq:cct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IE248_RS29115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="GCM10010336_t00830"
                     /product="tRNA-Arg"
     gene            complement(1671..1743)
                     /locus_tag="IE248_RS29115"
                     /old_locus_tag="GCM10010336_t00830"
     misc_feature    1844..1858
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(1933..1948)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            1944..2900
                     /locus_tag="IE248_RS29120"
                     /old_locus_tag="GCM10010336_59010"
     CDS             1944..2900
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740649.1"
                     /locus_tag="IE248_RS29120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59010"
                     /product="hypothetical protein"
                     /protein_id="WP_190032154.1"
                     /transl_table=11
                     /translation="MTYNLLTVDPVGPEIVALALAGCLGIAVGDVDVAGTDGDPDLRNW
                     DAPVSCEYRAVQGDVAWSLDVYAQERVADQPPESDLAAGFAKAAMTTVLFPAEEAPPSA
                     YWAVTPEGVLTRARLELSDDEPPLYAITAVEAPVPQLPGATVTRFAEIVREQRPDTPVA
                     WAFAESVEKVRQAASGLARLSLDDGTGSPVWTAKGNLVAWERVITQMESGWAPSGWYPA
                     GLYRERLESRDELAGIGAHLPRDVTELLDEALEQLDRRFAAATEDDLSGSLRRELTGGS
                     AEQTPLGWWWHRRPNPAPWEQACPLPGSVVKSKEINR"
     gene            2897..3607
                     /locus_tag="IE248_RS29125"
                     /old_locus_tag="GCM10010336_59020"
     CDS             2897..3607
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740648.1"
                     /locus_tag="IE248_RS29125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59020"
                     /product="contact-dependent growth inhibition system
                     immunity protein"
                     /protein_id="WP_190032155.1"
                     /transl_table=11
                     /translation="MTPSNDRFRELRELLSSYEETGYVFDDTEKRRGVALSAYLRQAAR
                     DPARAAEAAAEIDDLIETGLFSDEIADDVDLLPHINPPRGETVENCLAVIGGHLRQFLA
                     EPANPSQSPPHTAWEWRERFPGLQHLLAAYFHQDSSLEYSSYGEALDDYVSGASESDLR
                     QLADEIREFLILNESDQLLKKSAVTLGLAILPPRGVRLRQWLTDVRGIALQGTAPRSGS
                     GWGVQATRGGFGPS"
     gene            3641..6727
                     /locus_tag="IE248_RS29130"
                     /old_locus_tag="GCM10010336_59030"
     CDS             3641..6727
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891777.1"
                     /locus_tag="IE248_RS29130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59030"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_229895600.1"
                     /transl_table=11
                     /translation="MTAGVRFELLGPMRAYRGDERLGTGTPQQQAMLAVLLLRSGHGAG
                     LGELIDALWGEEPPHAAVTTLRTYAWRWRKVLAEPGVLVSVGDGYRLVLEKPCLDVQEA
                     EELAARAAVERGAGRREAAAKLLREALGLWQGEPLAALPGPYAERQRSRLEELRLRLLE
                     DRLELDIEAGGEAAAVPDLRLLTSEHPLRERPVALLMRALCRTGRQADALNLFRTARQG
                     LISEIGLEPGPELLSLHQRILSGDQELAGAEDGGRRGGPVALSGGPAPDTAAAVADGGG
                     GGGGGPEPEPEAPPVPAQTPSAPGDFTGRAALVRRLAEALTPAGDSGPALALISGMGGV
                     GKTALALHTADRVRDLFPDGQLYADLRGTDAHDPCDPGHVLVGFLAALGVTADALPADV
                     EGRAALFRSMTAGRRMLVVLDNARDAAQVRPLLPGPGRCAVLVTSRPRLAGLPARHQAD
                     LDVFELPEALELFGRVIGRDRLDAEPETARELVATCGFLPLAVRIVAARLAARPSWTVA
                     LLTARLADERRRLNELRVGDLAIAPVFELGYRQLSAEQARAFRVLACLDGPGIGLTSAA
                     AALGADEFHVEEVLESLVDVAMLESPTPGRYRFHDLLRTFGRQCAGAGAGAGAGAGARA
                     GAGAGAGADAGVGVDRAELAGALDGLLDHLLATACAAFRHAVPGDPVAAALGPLRARPL
                     SFAGLEPARIWALTESETALALAAQIAACARPGHPAWRGRLRAAIDLLIALSPFHQDTR
                     YGQLAPTGLLLAEAAARHGDRKAEGRARFLCGTIALKDTRLAEAETEARLAVLACREAG
                     DTVVLRQALNDLGLVAQFLRRFDEAIACFDEAIALARELDHRSGEYATTVNAALARVRS
                     GRAHEAVPACEAVLPGLREMDDRHGICYALYVLGLALHATGRYEEAIARYGDCLAVAGP
                     AGIRQRVAHARYRMADTLRAVGRHAEAQEQAEAALSLCRDLGSDRDSGHALVVLGRTLA
                     ERGRAEEARSRLLSASALFAKLGLPDVADVEELLAALPA"
     gene            complement(6792..7016)
                     /locus_tag="IE248_RS29135"
                     /old_locus_tag="GCM10010336_59040"
     CDS             complement(6792..7016)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS29135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_59040"
                     /product="hypothetical protein"
                     /protein_id="WP_073799535.1"
                     /transl_table=11
                     /translation="MTGTQKPTAAPPSRVRRAAAALVTGGLALGLVLGGAAAASADVAP
                     PPAPYVGTQLGDLAPPQGLVEGNWNSTGS"
     misc_feature    7042..7057
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.14"
                     /tool="antismash"
     gene            complement(7114..8976)
                     /locus_tag="IE248_RS29140"
                     /old_locus_tag="GCM10010336_59050"
     CDS             complement(7114..8976)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379740.1"
                     /locus_tag="IE248_RS29140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59050"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_229895601.1"
                     /transl_table=11
                     /translation="MTGAAEALLGTPQAGRATPAPALVPKPEPTPAAPSGLRLLLTRHL
                     RPHRGRLVAGAGLGLAGGLAGLAEPMAAKALIDRLVAGGSPTASAIGLGALVLASVLIT
                     AAGSYLLERTAEGVVRTTRERLAARVLRLPVADMDRQRPGDLVARLTSDTGQLRAAAGQ
                     ALAVCATSTLMVLGGLTAMFLLDPVLAGATVGVIGTVCGIGSLTLPRIGRAARRSQQVT
                     GELGAALERALGAFRTVKANGLERRETEAAREAAHRAWRSGVRAVGWEAAVEVASGLSV
                     RLAFLTVLGFGGTRVATGQMTMSALVAFLFYVLFIGPLLTQLAGSAGLVQRGSAAALRI
                     HEIECLAIEPLADADADAEPSAEPAAAPAAVPAAPLALELRDVRFGYPGRDTTVLDGLS
                     LDVPAGGLTALVGPSGAGKSTVFALLERFYEPTSGRILLDGRDVRDWPLTGLRATIGYV
                     EQDAPVLSGTLRDNLLRSAPRASPEELRAVLALTRLDGLVERLPAGLDTELGHRGTALS
                     GGQRQRVAIARALLRRPRLLLLDEATSQLDAENERALRDAVADIARETTVVVIAHRLST
                     VTGARRIVVLEDGRARATGTHRELLASDELYGRLVRTQLLDHRP"
     gene            complement(8973..9947)
                     /locus_tag="IE248_RS29145"
                     /old_locus_tag="GCM10010336_59060"
     CDS             complement(8973..9947)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019619.5"
                     /locus_tag="IE248_RS29145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59060"
                     /product="JmjC domain-containing protein"
                     /protein_id="WP_190032156.1"
                     /transl_table=11
                     /translation="MHRDELTRWVGDTDAFLDGHWRSAPAVFRPGTGSGTGTAAGPAAP
                     LSLEEIDAAVAGGLLRVPHLELARAGNPVHSSRYTRSRTVAGVTTPGYADPHRVRELLA
                     EGATLVLRNVEHWHPATRALTRRLEGELGRRVEAFFFVTPPGAQGLDLHRDDADVLLLQ
                     GTGSKHWTVRGGPAGPDWSPGEVADAGPALLSDTLRPGEVLYIPRGFAHEAVGGEGLSS
                     HLSLTIREAGTQQLFASLQRLLLDGLPLPARPLDDDALHAAAELLLERFRTRLPELTAE
                     ALLDHARRAQLAEGAVPGLGADPGIAALAARLDAPRDRAANAA"
     gene            complement(10001..11356)
                     /locus_tag="IE248_RS29150"
                     /old_locus_tag="GCM10010336_59070"
     CDS             complement(10001..11356)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="IE248_RS29150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59070"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_190032157.1"
                     /sec_met_domain="LANC_like (E-value: 3.7e-44, bitscore:
                     144.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAREHEALRARAAAAVTVVARRLADPAAADHPTPEVSPFRAASL
                     SDGAPGIALLHAELGAAVGGDPAHRDAALRWVRRAAALTALAGKTPAPGPQGLYGPLAA
                     LSFALHRTADGPAAHSAARSHLREQVAELASTRAAREERRLTEHPDASSAPGSGSGFTT
                     FTAYDVISGQSGLGAHLLELGRPAEAALVRVLRALVGLSRPVRTHDRGLPGWWVALDGA
                     SYQPVAPARGHANLGMAHGMPGPLALLAIAWREGVRVPGQRAAVTDLAQWLLARRCADA
                     AGPWWPGQLSLGPAQPEPGRPSWCYGTPGVARALQLAGLALEVPQWQEAGVEALRAALA
                     RADLDGPARAGGTAEAGLCHGLAGLLQITWRTARDSGDPELAERVPQLAARLLELLDEE
                     APFGFAAAPGERPPEEHPGGFLTGAAGAALALDTFARDAEPATRWDRALLLA"
     gene            complement(11353..14631)
                     /locus_tag="IE248_RS29155"
                     /old_locus_tag="GCM10010336_59080"
     CDS             complement(11353..14631)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="IE248_RS29155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59080"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_190032158.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.2e-200,
                     bitscore: 659.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.5e-18,
                     bitscore: 59.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.9e-32, bitscore:
                     106.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPAPHSGGDTPVPSAFRCSDTLLFRAAPRPPEPPGTAPDEDDV
                     LDGPDGQGAGGVTEADLRARLRRAAADARLREAVSLASPSLSRTLDAVLAGEPVRVKQL
                     RRAVRALARYRLRMSGRATPFGTMAGVAAIGFDEAPKAGWGERHRKAVRPDMGWLTEVV
                     ARLEREPAVLRPLRVTANDLCFVRGDRLVVPYLPAPGAGTRPAAQEVSVRASEVVLRLI
                     RRAATPVRFADLVPELVAAYPGVAAATVERLLVDLIGSEVLLTELRPPLDGADPLGHVL
                     ALLARGAEAEELPEGVTRTVAEMTAIQRELIAYAAAPLGSGLDARDSARRRMTALHPCD
                     QLLQVDLGLDVDIRLPEAVRAEVEAAAEALWRLASARPGPAHLRQYHEDFLERYGAGRS
                     VPLKELLDPDGGLGGPAGYRLPATARTLRGTPADPRGPQEQDRLLTELAQEASLNGERE
                     IVLDDVLLERLAGGAGSAADARSTPPPPLPPSFEILAQLLAATPEALADGDFRLVVTGG
                     ARTAGAHAGRFGFVLGADDARVTELVRQVPGAAPGAVTAQLRFPPPRGATANVALVPRR
                     LEHTITLGAFADRSGGAEGADGSDGTDLGVSDLAVVADVHRLAVVAPRLGREVVPVVPS
                     MLATVWHAPNAARFLHEVTENGLPAWPRWRWGTADTLPYLPRVRRGRTVLSPARWRPTD
                     PALQDRATDPGAWERLFDAWRSRWRVPDRVESVSGDNRIALDLRRPFHRGLLRDEWLRR
                     PGGVLQELPTSCGYGTGWLAEGPQGAGRVNEIAFPLVRRARPTAAPVRGSAVRPVAVVP
                     APRRVRTAYGPGSRWLYAKVYGSAERQDELLAHRLPSLLEGLPGAVDRWFYLRYRDPDS
                     HLRLRFHGDPAALTGDLLPRLAAWSDRLAEDGLGGRLVLDTYEPELERYGGAAAATAAE
                     RAFHADSVACLEQAALLERRELALDRTVLTALGYVDLACRVAGTTEGVRHLIDRAAPPG
                     AAEPARAAKDLARELVDPAGGWRHLRTLPGGPELLACWERRAPALAAYGTLLRELGAGP
                     GPLDALLHMHHNRLTGIDRPAEERSFALAAVALRSRLDRTRAEA"
     aSDomain        complement(13822..14100)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE248_RS29155_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.80E-19"
                     /identifier="RREFam001.1"
                     /label="IE248_RS29155"
                     /locus_tag="IE248_RS29155"
                     /protein_end="270"
                     /protein_start="177"
                     /score="59.6"
                     /tool="antismash"
                     /translation="VTANDLCFVRGDRLVVPYLPAPGAGTRPAAQEVSVRASEVVLRLI
                     RRAATPVRFADLVPELVAAYPGVAAATVERLLVDLIGSEVLLTELRPP"
     gene            complement(14717..14842)
                     /locus_tag="IE248_RS38290"
                     /old_locus_tag="GCM10010336_59090"
     CDS             complement(14717..14842)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS38290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_59090"
                     /product="hypothetical protein"
                     /protein_id="WP_008743001.1"
                     /transl_table=11
                     /translation="MTNVNDLFELDIIEIAAPVEDEQADAQAATGSWPFFCKTTI"
     misc_feature    complement(14933..14946)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            complement(15001..16551)
                     /locus_tag="IE248_RS29160"
                     /old_locus_tag="GCM10010336_59100"
     CDS             complement(15001..16551)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436077.1"
                     /locus_tag="IE248_RS29160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59100"
                     /product="glutamate synthase subunit beta"
                     /protein_id="WP_190032159.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-20, bitscore:
                     67.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDPFGFMKIPRRPVPARPVEARLGDWREVYAGQALLPLVSEQAN
                     RCMDCGLPFCHSGCPLGNLIPEWNAYAARGNWRAAYDRLHATNNFPEVTGRLCPAPCED
                     ACVLAINDDPVTIKNVEQAIADEGLRRGYLAPRPPERLSGKTVAVIGSGPAGLAAAQQL
                     TRAGHTVAVYERSDRLGGLLRYGIPEFKLEKEQVELRLGQMREEGTVFRTGVHVGGPGG
                     GSGGGSAGGAEGAGGAGAVSLDAAHLRRRFDAVVVAVGALEGRELPVPGRELSGIHQAM
                     EYLTCANRVREGDYPVSPVSAEGRHVIIVGGGDTGSDCLGTALRQGALSVVQLDINPLP
                     GETRPDHQPWPVYPKVYRISHAHEEARGRAGSDPRLFASATLRFEGDAGGRVRGLRLTA
                     VEPVARRPVGDSERVLPAELVLLALGFHGPERTGGLPDGLGLTWDARGTFARDAAFAAL
                     GGPRASGVFVAGDAGRGQSLVVWAIAEGRSAAAAVDRYLTGSTELPAPVSAYDVPLTA"
     gene            16652..16840
                     /locus_tag="IE248_RS29165"
     CDS             16652..16840
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS29165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_190032232.1"
                     /transl_table=11
                     /translation="MTRDQGQGRFTAAAGHAAARALRATAETLRGPVTVYVAHLPSVRV
                     PGIPGGAPRHGRVTRIW"
     gene            complement(16813..18090)
                     /locus_tag="IE248_RS29170"
                     /old_locus_tag="GCM10010336_59120"
     CDS             complement(16813..18090)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961134.1"
                     /locus_tag="IE248_RS29170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59120"
                     /product="M6 family metalloprotease domain-containing
                     protein"
                     /protein_id="WP_190032160.1"
                     /transl_table=11
                     /translation="MPQTRRRIRRPRRTRACIGLTVLVLGVTATASTGISTRSHSAAGP
                     VAATAESALAPCRIAGTMGVQMSEGLPTPPGYSRSTGEVRALNLMIDFPDAKGEGTAAD
                     RLAEFFPQTSDWFRTSSYGRLTYRAEAPIRDWLRMPMPFAAYGIERGSAYEPGYRQLVE
                     HIVKAADPEVDFSRYDLVNILVTPNAGPSALDTVLSVTFSGNAEAPVADGVPLANTSFI
                     YSRQDDGSGSYRETGFRVLPHENGHVFGLPDLYTAEGGGAVGHWDIMSEDWGANNDLLG
                     WHKWKLGWLDSTQISCAAKSGVSDHTLSPLAVGGGMKLAFIPLSESAGYAVEVRTQAGN
                     DEAVCEPGVLIYKVDSDVDTGRGPVIVSDSANTSGGCTRRPNVHAELSDAPFRPGETFT
                     DEKAGISVSVVGELRNGSYQIRVTRP"
     misc_feature    complement(18207..18222)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(18230..18245)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            18373..19035
                     /locus_tag="IE248_RS29175"
                     /old_locus_tag="GCM10010336_59130"
     CDS             18373..19035
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743005.1"
                     /locus_tag="IE248_RS29175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59130"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_100583106.1"
                     /transl_table=11
                     /translation="MKSPTTTPAAPALAVPKPRADAVRNRERILVAAREMLVESGVEAP
                     LDEIARRAGVGNATLYRHFPDRAALVHHVVLFVTDRVSAHAERALAEEPDAFAALRRFT
                     HAAADERIGALCPMLADDFDREHPELLASRDALEEAVQALLAAGQDSGLVRADIGVGDL
                     MMALSQLSRPLPGTACLQVDRFVHRHLGLFLDGLRAPARSELPGEAVTLDVLRRKTM"
     misc_feature    19080..19089
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.04"
                     /tool="antismash"
     misc_feature    19082..19096
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.4"
                     /tool="antismash"
     gene            19119..20663
                     /locus_tag="IE248_RS29180"
                     /old_locus_tag="GCM10010336_59140"
     CDS             19119..20663
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577555.1"
                     /locus_tag="IE248_RS29180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59140"
                     /product="MFS transporter"
                     /protein_id="WP_008743006.1"
                     /transl_table=11
                     /translation="MPKTAATSPLAADPSRWKALVFIALAQLMVVLDATIVNIALPSAQ
                     SDLGISDGNRQWVITAYALAFGGLLLFGGRIADKWGRKNAFIVGLIGFALASALGGAAN
                     GEAMMLGARGLQGAFGALLAPAALSLLAVMFTDATERAKAFGIYGAIAGGGGAVGLILG
                     GFLTEYLNWRWTFFVNIPFAIVAAVGAWLVIREPAHGRNRAPLDIPGVVLSTLGLVALV
                     YGFTRAESAGWSDAVTVGMFVASAVLLAAFVFVESRVKSPLLPLRVLLERNRGGVYLSL
                     GLAVIAMFGLFLFLTYYLQVVKGFSPVKTGFAFLPMIAGMITGSTQIGARLMTRVAPRL
                     LMGPGFLLAAVGMLLLTQLEVGSSYPALILPAQLLLGLGMGTAFMPAMSLATHGVNPAD
                     AGVASAMVNTSQQVGGAIGTALLNTIAASATTAYLTDHAAEAAAGGPAAKLVQAQAMVE
                     GYSSAIWWAVGILAASSAIALTLINTGRPGTGGPVASGDGEGAEAEAAVKIPVIAH"
     misc_feature    complement(19121..19130)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.89"
                     /tool="antismash"
     gene            20772..21551
                     /locus_tag="IE248_RS29185"
                     /old_locus_tag="GCM10010336_59150"
     CDS             20772..21551
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743007.1"
                     /locus_tag="IE248_RS29185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59150"
                     /product="dioxygenase"
                     /protein_id="WP_190032161.1"
                     /transl_table=11
                     /translation="MSATTRIPVLYLSHGAPPLADDPLWPGELAAWSADLPRPRAILMV
                     SAHWEEAPLALGATERVPLLHDFRGFPEHYYRVRYDAPGAPALAASVRGLLRAPGTPVQ
                     DVPDRGLDHGAYVPLVEMYPRADVPVLQISLPTLDPARLMAIGRKLAPLRDEGVLIVGS
                     GFFTHNLAALRHRGPGVPAWSAEFDAWGREALAASDVDALLDFERKSPAGRLAHPRTEH
                     FAPLFVTLGAAGPDLAAPRTPVDGFWLGLSKRSLQFG"
     gene            complement(<21698..22171)
                     /locus_tag="IE248_RS29190"
                     /pseudo=""
     CDS             complement(<21698..22171)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017496.5"
                     /locus_tag="IE248_RS29190"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="Uma2 family endonuclease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRRDRPTPDHALWLAWRGAVSALPEGFRAEIVEGCVEVSPTSRL
                     RHTGIANRLRKALDSAMAGSRPHALQCVYVIHGRRAWHPDVVVTSGDGPEQGTEDGIGI
                     RAEAVRLVVEVVSPGSDSITRDRTRKRRAYARAGIPVYVLIDDYDDGGTVTVLS"
     misc_feature    complement(22198..22213)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.77"
                     /tool="antismash"
     misc_feature    22364..22379
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(22389..22405)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            22664..23641
                     /locus_tag="IE248_RS29195"
                     /old_locus_tag="GCM10010336_59160"
     CDS             22664..23641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968470.1"
                     /locus_tag="IE248_RS29195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_59160"
                     /product="RNA polymerase sigma factor RpoD/SigA"
                     /protein_id="WP_073799528.1"
                     /transl_table=11
                     /translation="MATRAVARRQSSSSARAVGGEIADRDLVGMYLDEIARTPLLDAAK
                     EVELSQIIEAGVYARQILDGEAEREGEAPAREELEALAAEGERAKEVFIRSNLRLVVAV
                     ARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYAKGFKFSTYATWWIRQAITRSIADQSRT
                     IRLPVHLVEELGRIRRVQREFNREHGRDPEHAEIAAELDTTAKRVGDVLDWARDPVSLN
                     MSVDDDGDTQFGDLLEDTSAISPEQSVLSLLRSEELEDLLGKLDQRTASIIKMRYGIDD
                     GRERTLTEVGKQHGLTRERIRQIEKHALLELKKMARDTGFDAVA"
     misc_feature    23977..23992
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.91"
                     /tool="antismash"
ORIGIN
        1 cctcctccag cctccggaag aacccggcga gctgcgggtg ccgctccgcc agccagggaa
       61 acagcccggt gtcctccccg gtgtggtggg cctccagggt ctggcagaag gccaggcagt
      121 gctggcgcag ctgcatcccg accggcgcgc tctccccggc gggcagccgc agcagctcgg
      181 cgatctgtgc ccgcagccac ccgtggaccc gcgtcagcat gcccgcgatc ccgtcctcgg
      241 cgccctcggc gccctcggcg ccctcggcct catgggtgcg ctggagctcc acgacgggta
      301 tcacgcgccg ggtcttcctc tggtattccc cgtacccggg ctcctcccgc acgatgtgcg
      361 cgaacagctc ctcccaccgc gccccctcgg cgggcaccgc cacggcctcg taaacctcgg
      421 tcccggtctc cacccgtacg aggggccgcg cgagcaggtt gcggtaccag tccggatgcc
      481 ggtcggagcc gccggcggac ccgacgacgt acatcccctg cccgcccggc ccgcgcggac
      541 gccccagcgg ggtggtgtgc tctcgcccgg agcgcgcccc ggtggtggtg agcaggatga
      601 gcccggcccc ttcgaagggc ccgccgaccc ggccggcgtt ggcccggaat tcctctatga
      661 cggcttggtt gaacgacatg acgtggtgac ggtcctctcg cggtgtttgc gcatgcatga
      721 cggcagcaga acaaccgcgg aactcacccg tagtcggtgg cgacaacgcc catgacccgg
      781 tccttcacgt acaggtactc gcccggcgac cgcccggccc acatctcagt ggacggcccc
      841 acgtggtacc cggctataaa accacaccgc ctcagggcac ttggcgctgc gcgagcacct
      901 ccccggcgag cgcgcgacag cgggtgacct cttcgtcgaa ctcggcgttg tccatgtcca
      961 ggcccgcggc cgggccgggc aggcccgcga gctcccgcag cgccggttcg aagtccgggt
     1021 ccaggccctt gtggcacgtg ccgcagagcg tgaccaggtt ctcctcggct gtcggcccgg
     1081 ccatccgcca gggcacgagg tggtggaggt gcagctcgat gtccgtgtga tcgctcgccc
     1141 tgcgaccgca gaccacacac cgaaaaccgt cccgcttgag gacctgcatg cgcagcttcc
     1201 gggtgggcgc ccggcgctcg acggcgtcgt cgggaaggtg ctgcgtgacg aggtatccga
     1261 atccgccgga ctcggccgag ccgtcgtgca cgcactcctt gggggcgatc acgctggaca
     1321 gccggtcttc ggcgacctgc ctgccgacca aggcgttccg gcggtccagg ccttgcggat
     1381 gaattcgggg tcgacgaggc acgcggcgcg gatctcccag cgcgggttcc gctcggagaa
     1441 gcccacccag tgcgtctgcg ctgaccaggc cacctcgccg gttggccccg agggtcagcg
     1501 cgtagtagtc gcccgcaggg tcgtaggcct tcatgctccg aagcgtctgc aacagccgtt
     1561 ccccggccgc ttcctgcgtg tctcccatgg cgcgactgtc ccaccgcggt ctgacggcca
     1621 gagacgtcaa aagaccccca gccaagatcg gctgagggtc ttccaccacg tgcccccggc
     1681 aggattcgaa cctgcgacac ccgctttagg agagcggtgc tctatcccct gagctacgaa
     1741 ggcgaggcat ggaggcctgg cggtgaggcc gggccaccgc ggtcagtgta gcgggtggtg
     1801 catgatccgt aggggagagg tgatcgacag ccgcgacatc ctgatcgcgc aggtcgatca
     1861 gcggggtcgt ccacgggctg gcctgatgaa cctttcggac gcatcgtcga gaaagcgctg
     1921 gccatctaga aggggacgta tccgtgacgt acaacctcct taccgtcgac cccgtcggcc
     1981 ccgagatcgt ggccctcgca cttgcgggat gcctcggtat cgcggtgggt gacgtggacg
     2041 tggcgggtac tgacggcgac cccgacctcc gcaactggga tgcgcccgtc tcgtgcgaat
     2101 accgggctgt tcaaggtgat gtggcctggt cgctggacgt ctacgcccag gaacgcgtcg
     2161 ctgatcagcc gcccgagtcc gacctcgccg cagggttcgc gaaggccgcc atgacgacag
     2221 tcctgtttcc cgctgaggaa gcaccgccca gtgcctactg ggcggtgacg ccggaaggcg
     2281 ttctcacccg ggcccggctc gaactctccg acgacgagcc tcccctttac gcgatcaccg
     2341 ccgtcgaggc gccggtgccg cagctgcccg gggcgaccgt gacgagattc gccgagatcg
     2401 tacgggaaca gcggccggac acgccggtcg cctgggcctt cgcggaatcg gtggagaagg
     2461 tgcggcaggc cgcctcgggc ctcgcgaggc tttccctcga cgacggcacc ggcagccccg
     2521 tctggaccgc gaagggcaac ctggtggcgt gggagagggt catcacgcaa atggaatccg
     2581 ggtgggcgcc gtcgggctgg tatccggccg gcctttaccg ggagcggctg gaatcgcgtg
     2641 acgagctggc cggaatcggt gctcacctgc cgcgtgatgt cactgagctg ctcgacgagg
     2701 ccctggagca gctggacagg cggtttgccg ctgcgacgga ggatgacctg tcagggagtc
     2761 tccgcagaga gctgaccggc ggctccgcag agcagacgcc gctcggctgg tggtggcacc
     2821 gccgcccgaa tcccgcaccg tgggaacagg cctgcccgct cccggggtcc gtagtgaaga
     2881 gtaaggaaat caacaggtga caccgtcgaa cgaccgtttt cgtgagctgc gtgagctcct
     2941 gtcctcttat gaagagactg gttatgtctt cgatgacaca gagaagcgta ggggagttgc
     3001 gctcagcgcc tacctcaggc aagccgcacg cgatcccgca cgcgccgccg aggcagcggc
     3061 cgaaatcgac gacctcatcg agacaggcct gttcagcgat gagatcgcgg atgacgtcga
     3121 cctcttgccc cacatcaacc cgccccgcgg ggagacggtg gagaactgcc tcgccgtcat
     3181 tggcgggcac ctgcgtcagt tcctcgcaga gccggcgaat ccctcccagt cgcctcctca
     3241 caccgcatgg gaatggaggg aacgctttcc cggactccag cacctgctgg cggcgtattt
     3301 ccatcaggac tcctcgctgg agtactcctc ttatggggag gctctcgacg actacgtctc
     3361 aggtgcctcg gaaagtgacc ttcggcagtt ggcggatgag attcgcgaat tcctgatcct
     3421 caacgaatcg gatcaactcc tcaagaagtc ggcggtgacg ctggggcttg ccattcttcc
     3481 gccacgaggc gtgcgcctgc gtcagtggct gacggacgtg cgggggatcg cgctccaggg
     3541 aaccgcgccc cggagcggga gtggttgggg ggtgcaggca acccgagggg ggtttgggcc
     3601 ctcctgatgg aggcgggggg aggcgactac agggggcgga atgacggcag gggtgcggtt
     3661 cgagctgctg gggccgatgc gggcctatcg gggggacgag cggctcggga cggggacgcc
     3721 gcagcagcag gccatgctgg cggtgctgtt gctgcggtcc gggcacgggg ccgggctcgg
     3781 ggagctcatc gacgcgctgt ggggtgagga gccgccgcac gcggccgtga ccaccctgcg
     3841 gacgtacgcc tggcggtggc ggaaggtgct ggcggagccc ggggtgctcg tctccgtcgg
     3901 ggacgggtac cggctcgtgc tggagaagcc gtgcctcgac gtgcaggagg ccgaggagct
     3961 ggccgcccgg gccgccgtcg agcggggcgc ggggcggcgc gaggcagccg cgaagctgct
     4021 gcgggaggcg ctcgggctgt ggcaggggga gccgctggcc gcgctgccgg ggccgtacgc
     4081 ggagcgccag cggtcccgtc tggaggagct gcggctgcgc ctgctggagg accgcctgga
     4141 gctggacatc gaggcgggcg gcgaggccgc ggccgtgccc gacctgcggc tgctgacctc
     4201 cgaacacccg ctgcgggagc ggcccgtggc gctcctgatg cgggccctgt gccggacggg
     4261 ccgtcaggcc gacgccctga acctgttccg taccgcccgc caggggctga tcagcgagat
     4321 cggcctggag cccggaccgg agctgctgtc gctgcaccag cgcatcctga gcggcgacca
     4381 ggaactcgcc ggggccgagg acggcgggcg ccggggcggc cccgtcgccc tgtccggcgg
     4441 gcccgcgccg gacactgccg ccgccgtggc ggacggcggg ggagggggcg ggggcgggcc
     4501 ggagcccgag ccggaggcgc cgcccgtgcc cgcgcagacg cccagcgcgc ccggtgactt
     4561 caccggccgg gccgccctcg tacgacgcct tgccgaggcc ctgaccccgg ccggcgacag
     4621 cgggccggcc ctcgcgctga tctccggcat gggcggagtc ggcaagacgg ccctcgccct
     4681 ccacaccgcc gaccgggtac gggacctctt ccccgacggc cagctgtacg ccgacctgcg
     4741 cggcaccgac gcccacgacc cctgcgaccc cggtcacgtc ctggtcggtt tcctcgccgc
     4801 gctcggggtc accgcggatg ccctgcccgc cgacgtcgag gggcgggcgg cgctgttccg
     4861 gtcgatgacc gccggccgcc ggatgctcgt cgtgctcgac aacgcgcgcg acgccgccca
     4921 ggtgcgcccg ctgctgcccg gccccggccg gtgcgccgtc ctcgtcacca gcagacccag
     4981 gctggcgggg ctgcccgccc ggcaccaggc cgacctggac gtcttcgagc tccccgaggc
     5041 gctggagctg ttcggccggg tgatcggccg cgaccggctg gacgccgaac ccgaaaccgc
     5101 ccgcgagctc gtcgccacct gcgggttcct gcccctggcc gtccggatcg tggccgcccg
     5161 gctcgccgcc cgccccagct ggacggtcgc cctgctcacc gcccggctgg ccgacgagcg
     5221 ccgccgactc aacgagctgc gcgtcggcga tctggccatc gcccccgtct tcgagctcgg
     5281 ctaccgccag ctctccgccg aacaggcgcg cgccttccgg gtgctggcct gcctcgacgg
     5341 ccccggcatc ggcctgacct ccgccgcggc ggccctgggg gccgatgagt tccacgtgga
     5401 ggaggtactg gaatccctgg tggacgtggc gatgctggag tccccgacgc ccggccggta
     5461 ccgcttccac gacctgctgc gcaccttcgg ccgccaatgc gcgggagcgg gagcgggagc
     5521 cggagcaggt gccggagccc gagccggtgc cggtgccggt gccggtgccg acgccggcgt
     5581 cggcgtcgac cgggccgagc tggcgggcgc cctcgacggg ctcctcgacc acctcctcgc
     5641 caccgcctgc gccgcgttcc ggcacgccgt acccggcgac cccgtcgcgg cggcgctcgg
     5701 cccgctgcgc gcgcgaccgc tgtccttcgc cgggctggag cccgcccgga tctgggcgct
     5761 gaccgaatcg gagaccgccc tcgcgctggc cgcgcagatc gcggcctgcg cccggcccgg
     5821 acaccccgcc tggcgcgggc ggctgcgcgc cgccatcgac ctgctgatcg ccctgagccc
     5881 cttccaccag gacacccgct acggccagct cgcccccacc ggcctgctcc tcgccgaggc
     5941 cgccgcccgg cacggcgacc gcaaggccga ggggcgggcc cgcttcctgt gcgggacgat
     6001 cgcgctcaag gacacccggc tcgcggaggc cgagaccgag gcgcggctcg ccgtactggc
     6061 ctgccgcgag gccggcgaca ccgtggtgct gcgccaggcc ctcaacgacc tcggcctggt
     6121 cgcacagttc ctgcgccgct tcgacgaggc catcgcgtgc ttcgacgagg ccatcgcgct
     6181 cgcccgggaa ctcgaccacc gctccggcga gtacgccacc accgtcaacg cggccctcgc
     6241 ccgggtccgc agcggccgcg cccacgaggc cgtcccggcc tgcgaggccg tactgccggg
     6301 gctgcgggag atggacgacc ggcacggcat ctgttacgcc ctgtacgtcc tcgggctcgc
     6361 gctgcacgcc acgggccggt acgaggaggc gatcgcgcgg tacggggact gcctggccgt
     6421 cgccgggccc gccgggatcc gccagcgggt ggcgcacgcc cgctaccgga tggccgacac
     6481 gctgcgcgcg gtgggccggc acgcggaggc ccaggaacag gcggaggcgg cgctgtcgct
     6541 gtgccgcgac ctcggctccg accgggacag cgggcacgcg ctggtggtgc tcggccggac
     6601 gctggccgag cgcggccgcg ccgaggaggc ccggagccgg ctgctcagcg cgtcggcgct
     6661 gttcgccaag ctcggcctgc cggacgtggc ggacgtcgag gaactcctgg cggcgctgcc
     6721 cgcctgagcc gccgccccgc gctgccccgc gctgccccgc gccgcggccc ggcgcccagg
     6781 agccccggtg ctcaggagcc ggtgctgttc cagttcccct ccacgaggcc ctgcgggggt
     6841 gccaggtcgc cgagctgggt gccgacgtac ggcgcgggcg gcggtgccac gtcggcgctc
     6901 gccgcggcgg ccccgcccag tacgagaccc agggccaggc cgcccgtcac gagggcggcg
     6961 gcggcccgcc ggacgcggga ggggggcgcg gcggtgggct tctgcgtacc ggtcatgtgg
     7021 atcagtcctt cgtcggaaga gcgtggtcgg gaccagtatc cgaagcgcgg gtcaatcccg
     7081 gatcgacgcc ggatcaacgt ctcggagtcc aggtcacggg cggtggtcca gcagctgggt
     7141 gcgcaccagc cgcccgtaca gctcgtccga ggcgagcagc tcccggtgcg tcccggtcgc
     7201 gcgcgcccgc ccgtcctcca ggaccacgat ccggcgggcg ccggtgacgg tggacagccg
     7261 gtgcgcgatc accacgaccg tcgtctcccg ggcgatgtcc gcgaccgcgt cgcgcagcgc
     7321 ccgctcgttc tcggcgtcca gctgcgaggt cgcctcgtcg agcagcagca gcctgggccg
     7381 gcgcagcagg gcgcgcgcga tggccacgcg ctggcgctga ccgcccgaca gggccgtgcc
     7441 gcggtgcccg agctcggtgt ccaggccggc gggcagccgc tccacgagcc cgtccagccg
     7501 ggtcagcgcg aggaccgccc gcagctcctc gggcgaggcc cggggcgcgg accgcagcag
     7561 gttgtcccgc agggtgccgg acagcaccgg ggcgtcctgc tccacgtacc cgatggtggc
     7621 gcgcaggccg gtcagcggcc agtcccgtac gtcgcggccg tcgagcagga tccggcccga
     7681 agtgggctcg tagaaccgct ccagcagcgc gaacacggtg ctcttgccgg cgccggaggg
     7741 gccgacgagc gcggtgagcc cgcccgccgg gacgtcgagc gacaggccgt cgaggacggt
     7801 ggtgtcccgc cccgggtacc cgaaacggac gtcgcgcagc tccagcgcga gcggcgcggc
     7861 cggcactgcg gcgggggccg cggcaggctc ggcagaaggc tccgcgtccg cgtctgcgtc
     7921 cgctagcggc tcgatggcca ggcactcgat ctcgtggatg cgcagggccg cggccgagcc
     7981 ccgctgcacc agccccgcgc tcccggcgag ctgggtgagc agcgggccga tgaacaggac
     8041 gtagaagagg aaggcgacca gcgccgacat ggtcatctgc ccggtcgcca cccgggtccc
     8101 gccgaagccc agcaccgtga ggaacgccag ccgtacggag agcccggagg cgacctcgac
     8161 ggcggcctcc cagccgacgg cccgcacccc gctgcgccag gcccggtggg cggcctcgcg
     8221 ggcggcctcg gtctcccgcc gctccaggcc gttcgccttg acggtacgga aggcgccgag
     8281 cgcgcgttcc agcgcggccc cgagctcacc ggtgacctgc tgggagcggc gggccgcccg
     8341 gccgatccgg ggcagggtga gcgaaccgat cccgcagacg gtgccgatca cgccgacggt
     8401 ggcgcccgcc agcaccgggt ccagcaggaa catcgcggtg aggcccccga gcaccatcag
     8461 cgtggaggtg gcgcagaccg cgagggcctg cccggccgcc gcccgcagct ggccggtgtc
     8521 ggaggtcagc cgggcgacca ggtctccggg gcgctggcgg tccatgtcgg ccaccggcag
     8581 ccgcagcacg cgggcggcga gccgctcgcg ggtggtgcgg accacgccct cggcggtgcg
     8641 ctccagcagg tacgacccgg ccgccgtgat cagtacggag gccagcacca gggcgccgag
     8701 cccgatcgcg gaggcggtgg gcgagccgcc cgcgaccagc cggtcgatga gggccttggc
     8761 ggccatcggc tcggcgagcc cggcgagccc gccggccagc ccgagcccgg cccccgccac
     8821 gagccgcccc cggtggggcc gcagatgccg cgtcagcagc agccgcagcc cggagggcgc
     8881 ggcgggtgtg ggttcgggct tgggtacgag ggcgggcgcg ggtgtcgcgc gccctgcctg
     8941 cggtgtgccg agcagggcct cggcggcgcc ggtcacgcgg cgttcgccgc ccggtcccgg
     9001 ggcgcgtcga gccgtgcggc cagcgccgcg atccccgggt ccgcgccgag cccgggcacc
     9061 gcgccctcgg cgagctgcgc ccggcgcgcg tggtccagga gggcttcggc ggtcagctcc
     9121 ggcagccgtg tccggaaccg ctccagcagc agctcggcgg ccgcgtgcag ggcgtcgtcg
     9181 tccagcgggc gggccggcag cggcaggccg tccagcagca gccgctgcaa cgaggcgaac
     9241 agctgctgcg tgcccgcctc ccggatcgtg agcgagaggt gcgaggagag cccctcgccg
     9301 cccaccgcct cgtgggcgaa gcccctcggg atgtacagca cctccccggg gcgcagggtg
     9361 tccgagagca gggcagggcc ggcgtcggcg acctcgccgg gactccagtc ggggccggcg
     9421 gggccgccgc gcaccgtcca gtgcttgctg ccggtgccct ggagcagcag tacgtcggcg
     9481 tcgtcgcggt gcaggtccag gccctgtgcc cccggcgggg tgacgaagaa gaacgcctcg
     9541 acgcggcggc cgagttcgcc ctccaggcgg cgggtcagcg cccgcgtggc cgggtgccag
     9601 tgctcgacgt tgcgcagcac cagcgtggcg ccctcggcga gcagctcccg tacccggtgc
     9661 ggatcggcgt agccgggggt ggtgacgccg gcgacggtgc gggaccgggt gtagcgggag
     9721 gagtgcaccg ggttgccggc ccgggcgagt tcgaggtgcg gcacgcgcag caggccgccc
     9781 gcgacggcgg cgtcgatctc ctccagggag agcggggcgg cgggtccggc ggcggtgccg
     9841 gtgccgcttc cggtgccggg ccggaagacg gcgggcgcgg accgccagtg gccgtcgagg
     9901 aaggcgtccg tgtcgcccac ccagcgggtg agttcgtccc ggtgcatggg gtctcttctc
     9961 tgtgtcgagt acgtcggtca ggtggccggg gccgggcagg tcaggccagc agcagcgcgc
    10021 ggtcccagcg cgtggccggc tcggcgtcgc gggcgaaggt gtccagggcg agcgccgccc
    10081 cggccgcgcc ggtcaggaag ccgcccggat gttcctctgg cggacgttcg ccgggcgcgg
    10141 cggcgaagcc gaacggcgct tcctcgtcga ggagttccag cagccgggcc gccagctgcg
    10201 ggacccgctc ggcgagttcg gggtcgccgc tgtcgcgggc ggtgcgccag gtgatctgga
    10261 gcagccccgc cagcccgtgg cagagcccgg cctcggccgt cccgccggcc cgggccggtc
    10321 cgtccagatc ggcgcgggcc agcgcggccc gcagcgcctc gacgccggcc tcctgccact
    10381 gcggcacctc cagggccagg cccgccagct ggagggcccg ggcgacgccg ggggtgccgt
    10441 agcaccagga ggggcggccg ggttcgggct gcgcgggccc cagcgacagc tggccgggcc
    10501 accaggggcc cgcggcgtcc gcgcaccgcc gcgcgaggag ccactgtgcg aggtcggtga
    10561 cggcggcccg ctgccccggc acccgcaccc cctcccgcca ggcgatggcc agcagcgcca
    10621 gcgggccggg catgccgtgg gccatgccca ggttcgcgtg cccgcgcgcc ggggccaccg
    10681 gctggtacga ggcgccgtcc agcgccaccc accagccggg cagtccgcga tcgtgggtac
    10741 ggaccggccg gctgagcccg accagcgccc gcagcacccg cacgagggcg gcctcggccg
    10801 gacgcccgag ctccagcaga tgcgcaccga gcccgctctg cccactgatc acgtcgtacg
    10861 cggtgaaggt cgtaaagccg gacccggagc ccggggcgga gctcgcgtcg gggtgttcgg
    10921 tgaggcggcg ttcttcgcgg gcggcgcggg tggaggcgag ttccgctacc tgttcccgca
    10981 ggtgggagcg ggccgcgctg tgcgcggccg ggccgtcggc cgtccggtgc agggcgaacg
    11041 acagcgcggc cagcggcccg tacagcccct gcggcccggg ggccggggtc ttcccggcga
    11101 gcgcggtgag cgcggcggcc cgccgcaccc accgcagcgc ggcgtcccgg tgcgccggat
    11161 cgccccccac tgcagcgccg agttccgcgt ggagcagggc gatgcccggg gcgccgtcgc
    11221 tgaggctggc cgcgcggaac ggggagacct ccggcgtcgg gtggtccgcg gcggcagggt
    11281 ccgcgaggcg ccgggcgacg accgtcacgg cggcggcggc ccgcgcgcgc agcgcctcgt
    11341 gctcccgcgc gctcacgctt cggccctcgt acggtccagg cggctgcgca gcgccacggc
    11401 ggccagggcg aaggagcgct cctccgcggg gcggtcgatg cccgtgaggc ggttgtggtg
    11461 catgtgcagc agcgcatcca acggccccgg accggcgccg agttcccgca gcagcgtccc
    11521 gtacgcggcc agcgccggcg cgcgccgctc ccagcaggcg agcagctccg ggccgccggg
    11581 cagcgtgcgc aggtgccgcc agccgccggc cgggtcgacc agctcccggg ccaggtcctt
    11641 ggcggcgcgg gccggctcgg cggcccccgg cggcgccgcg cggtcgatca ggtgccggac
    11701 gccctccgtg gtgccggcga cccggcaggc caggtcgacg tacccgaggg ccgtcagcac
    11761 ggtgcggtcc agcgccagtt cgcggcgctc cagcagcgcg gcctgctcca ggcaggcgac
    11821 gctgtcggcg tggaaggcgc gttcggcggc ggtcgccgcg gcggcgcccc cgtagcgttc
    11881 gagttcgggc tcgtaggtgt ccaggaccag ccggcccccg agcccgtctt cggcgagccg
    11941 gtccgaccag gcggcgaggc ggggcagcag gtccccggtg agtgcggccg ggtcgccgtg
    12001 gaagcgcagc cgcaggtggg agtcggggtc gcggtagcgc aggtagaacc agcggtcgac
    12061 cgcgccgggc agcccctcca gcaggctcgg cagccggtgg gcgaggagct cgtcctggcg
    12121 ctcggccgag ccgtacacct tggcgtacag ccaccgcgag ccgggaccgt acgcggtacg
    12181 gacgcgccgg ggcgcgggca cgacggccac cggccggacg gcggaacccc gtaccggcgc
    12241 ggccgtcggc cgcgcccgcc ggaccagcgg gaacgcgatc tcgttgaccc ggcccgcccc
    12301 ctgagggccc tcggccagcc agcccgtccc gtacccgcag ctcgtcggca gctcctggag
    12361 gacgccgccg ggccgccgca gccactcgtc gcgcagcagc ccccggtgga agggccggcg
    12421 caggtcgagg gcgatgcggt tgtcgccgct gacgctctcc acccggtcgg gcacccgcca
    12481 gcgggagcgc caggcgtcga agagccgctc ccacgcgccc gggtcggtgg cccggtcctg
    12541 gagcgccggg tccgtcgggc gccagcgggc cggggagagc acggtacggc cgcgccggac
    12601 cctcggcagg tacggcaggg tgtcggcggt gccccagcgc cagcgcggcc aggccgggag
    12661 cccgttctcg gtcacctcgt gcaggaagcg ggcggcgttc ggcgcgtgcc agaccgtcgc
    12721 gagcatgctg gggacgacgg ggacgacctc gcggcccagc cggggcgcga ccaccgcgag
    12781 ccggtgcacg tcggcgacga cggccagatc ggacacgccg aggtcggtgc cgtcgctgcc
    12841 gtcggcgccc tcggccccgc cggagcggtc ggcgaacgcg cccagggtga tggtgtgttc
    12901 caggcgccgc ggcaccagcg ccacgttggc ggtcgcgccg cgcggcggcg ggaacctcag
    12961 ctgtgcggtg acggcgcccg gcgcggcccc cggcacctgc cggaccagct cggtgacccg
    13021 ggcgtcatcg gcgccgagca cgaacccgaa ccgcccggcg tgcgcccccg cggtgcgcgc
    13081 cccaccggtg acgaccagcc ggaagtcccc gtcggcgagc gcctcggggg tggcggcgag
    13141 cagctgcgcg aggatctcga acgacggcgg caggggcggc gggggcgttg agcgcgcgtc
    13201 cgcggcgctc ccggcgcccc cggccagccg ctccagcagt acgtcgtcca gcacgatctc
    13261 ccgctccccg ttgagggagg cctcctgcgc gagctcggtc agcagccggt cctgctcctg
    13321 cggcccgcgc gggtccgccg gtgtgccgcg cagggtccgc gcggtggcgg gcagccggta
    13381 cccggcggga ccgccgaggc cgccgtccgg atcgaggagt tccttgagcg gtacggagcg
    13441 cccggcgcca tagcgttcga ggaagtcctc gtggtactgg cgcagatggg ccgggcccgg
    13501 ccgggcggag gccagccgcc acagcgcctc ggcggccgct tccacctcgg cgcgcacggc
    13561 ctccggcagc cggatgtcca cgtcgagccc cagatccacc tggagcagct ggtcgcaggg
    13621 gtgcagggcg gtcatccggc ggcgcgcgga gtcccgggcg tcgagcccgg aacccagcgg
    13681 ggccgccgcg tacgcgatca actcgcgctg gatcgcggtc atttcggcga cggtccgggt
    13741 caccccctcg ggcagctcct ccgcctccgc gccccgcgcc agcagggcca gtacgtggcc
    13801 gagcggatcg gcaccgtcca gcggcggccg cagctccgtc aggagcacct cggagccgat
    13861 gaggtcgacg aggagccgct ccacggtcgc ggcggccacc ccggggtagg cggcgacgag
    13921 ctcggggacc aggtcggcga accggacggg ggtggcggcg cgccggatca ggcgcagcac
    13981 cacctcgctc gcccgcaccg agacctcctg ggcggccggc cgggtgcccg ctccgggcgc
    14041 gggcaggtac gggacgacca gccggtcgcc ccgtacgaag cacaggtcgt tggcggtgac
    14101 gcgcagcggc cgcaggactg cgggctcgcg ctccaggcgg gccaccacct cggtcagcca
    14161 gcccatgtcg ggccggacgg ccttgcggtg ccgctcgccc cagccggcct tgggcgcctc
    14221 gtcgaagccg atggcggcga ccccggccat ggtgccgaag ggcgtggccc ggccggacat
    14281 ccgcagccgg tagcgggcca gcgcccgtac cgcgcggcgc agttgtttga cgcggaccgg
    14341 ctccccggcg agcaccgcgt cgagggtgcg gctcagtgac gggctcgcca gcgagaccgc
    14401 ctcccggagc cgggcgtcgg ccgcggcgcg gcggagccgg gcccgcaggt ccgcctccgt
    14461 gacgccaccg gcgccctgcc cgtcgggccc gtcgagcacg tcgtcctcgt cgggcgcggt
    14521 gccgggcggc tccggcggcc ggggcgcggc ccggaacagc agggtgtccg agcagcggaa
    14581 cgccgacgga acgggggtgt caccgcccga gtggggagcg ggtgccgcca cggggagcct
    14641 ccaggaaaga gcgggggaac aagagaggcg gcccggggga gggccgcctc tactagtgct
    14701 tctgcgtgac cgaccctcag atggtggtct tgcagaagaa cggccaggag ccggtcgcgg
    14761 cctgggcgtc ggcctgctcg tcctcgacgg gggcggcgat ctcgatgatg tccagctcga
    14821 acaggtcgtt gacgttggtc atgacgtctc cttgattgcg gtgcgccccc gtctccggcg
    14881 gcgtcctccg ggcttgtccc cggcggcatg tgaagaccgt acgaagcccg gagcaacgtg
    14941 tgttcgacgc gggatcgacg cccgatcaac gcccccggag ccccccgcca gggcctcccg
    15001 tcaggccgtc agcggaacgt cgtacgccga gaccggcgcg ggcagttcgg tcgagccggt
    15061 caggtagcgg tcgacggcgg cggccgccga ccggccctcg gcgatggccc acaccaccag
    15121 cgactgcccc cgccccgcgt cccccgcgac gaagaccccg gaggcccgcg gaccgccgag
    15181 ggcggcgaag gccgcgtcgc gggcgaaggt gccgcgggcg tcccaggtca ggccgagccc
    15241 gtcgggcagg cccccggtcc gctccgggcc gtggaacccg agcgccagca gcaccagctc
    15301 ggccggcagg acgcgctcgc tgtcgccgac cggccgccgg gccaccggtt ccacggcggt
    15361 caggcgcagg ccccggacgc ggcccccggc gtcgccctcg aagcgcaggg tggcgctggc
    15421 gaagagccgg gggtcgctgc cggcccggcc gcgcgcctcc tcgtgggcgt gggagatccg
    15481 gtagaccttc gggtacaccg gccagggctg gtgatccggc cgggtctcgc cgggcagcgg
    15541 gttgatgtcc agctggacca ccgagagcgc gccctgccgc agcgcggtgc ccaggcagtc
    15601 ggagccggtg tccccgccgc cgacgatgat cacgtgccgg ccctcggcgc tgaccgggga
    15661 caccgggtag tcgccctcgc ggacccggtt ggcgcaggtc aggtactcca tcgcctggtg
    15721 gatgccggac agctcgcggc cggggacggg cagctcccgg ccctccaggg cgccgaccgc
    15781 gacgacgacg gcgtcgaacc gccgccgcag gtgcgccgcg tcgagggaca cggctcccgc
    15841 gccgcccgct ccttccgctc cgcccgccga gccgcctccc gagccgcctc ccgggccgcc
    15901 gacgtgcacc cccgtacgga agaccgtccc ctcctcccgc atctggccga gccgcagctc
    15961 cacctgctcc ttctccagct tgaactccgg tatcccgtag cgcagcagcc cgccgagccg
    16021 gtcggagcgc tcgtacacgg cgacggtgtg cccggcgcgc gtcagctgct gggccgcggc
    16081 gagtccggcc gggccggagc cgatcacggc cacggtcttg ccgctgagcc gctccggggg
    16141 gcgcggcgcg aggtagccgc ggcgcagacc ctcgtcggcg atggcctgct cgacgttctt
    16201 gatcgtcacc gggtcgtcgt tgatcgccag cacgcaggcg tcctcgcagg gggccgggca
    16261 gagccggccg gtcacctcgg ggaagttgtt ggtggcgtgc agccggtcgt acgcggcgcg
    16321 ccagttcccg cgggccgcgt acgcgttcca ctcggggatc aggttcccca gcgggcagcc
    16381 gctgtggcag aagggcagac cgcagtccat gcaccggttg gcctgctcgg agaccagcgg
    16441 cagcagcgcc tgacccgcgt acacctcgcg ccagtccccc agccgcgcct cgacggggcg
    16501 ggcgggcacc ggacgccgcg ggatcttcat gaacccgaac ggatcggtca tgcgccgcct
    16561 ccctcttcgc gccgccacct caggctacgc cgacaccccc gccatctccc gtcgtcccgg
    16621 cgcggggcgt ccacagggca tgatccggaa cgtgacgcgc gaccagggcc agggccgttt
    16681 caccgccgcc gcgggtcatg ccgctgcccg cgccctgcgc gccaccgccg agaccctgcg
    16741 gggccccgtc acggtgtacg tggcgcacct gccctccgtc cgcgttcccg ggatcccggg
    16801 aggggctccg cgtcacggcc gggtgacccg gatctggtag ctcccgttgc gcagctcgcc
    16861 gacgaccgag acgctgatgc ccgccttctc gtcggtgaag gtctcgcccg gcctgaacgg
    16921 ggcgtccgac agttccgcgt gcacgttggg ccgccgcgta cagccgccgc tggtgttcgc
    16981 gctgtccgac acgatcaccg ggccgcgccc ggtgtccacg tccgagtcca ccttgtagat
    17041 gagtacgccc ggctcgcaca cggcctcgtc gttcccggcc tgggtccgca cctccaccgc
    17101 gtacccggcg ctctccgaca gcggtatgaa ggccagcttc atgccgcccc ccaccgccag
    17161 cggcgacagg gtgtggtcgc tgacgcccga cttcgcggcg cagctgatct gcgtgctgtc
    17221 cagccagccc agcttccact tgtgccagcc cagcaggtcg ttgttggcgc cccagtcctc
    17281 gctcatgatg tcccagtgcc cgaccgcgcc gccgccctcg gcggtgtaca ggtccggcag
    17341 tccgaagacg tgcccgttct cgtgggggag cacccggaag ccggtctccc ggtaggagcc
    17401 cgagccgtcg tcctgccggc tgtagatgaa ggacgtgttg gcgagcggca ccccgtcggc
    17461 gacgggcgcc tcggcgttcc cggagaaggt caccgacagc acggtgtcca gtgcggaggg
    17521 cccggcgttc ggcgtgacga ggatgttgac caggtcgtac cggctgaagt ccacctcggg
    17581 gtcggcggcc ttcacgatgt gctcgacgag ctgccggtag cccggctcgt aggcggaccc
    17641 gcgctcgatc ccgtacgccg cgaacggcat cggcatccgc agccagtccc gtatgggggc
    17701 ctcggcccgg taggtcagcc gcccgtagga gctggtcctg aaccagtcgg aggtctgggg
    17761 gaagaactcg gccagccggt cggccgccgt gccctcgccc ttggcgtccg ggaagtcgat
    17821 catcaggttc agcgcgcgga cctcgccggt ggaccgggag tacccgggcg gggtcggcag
    17881 gccctcggac atctggacgc ccatcgtgcc ggcgatccgg cagggcgcga gcgccgattc
    17941 ggcggtcgcc gccactggtc ccgcggcgga gtggctccgg gtggatattc cggtgctcgc
    18001 ggtcgcggtg acgccgagga cgagcacggt gaggccgatg cacgcgcggg tgcggcgtgg
    18061 tctgcgtatc cggcggcggg tctgcggcat ggagagcgcc ttcggggtcc gcggcagccg
    18121 gccgggcccg gtctgcactc cgtgggctca ccctccgtcg gctgcgacgc gcccgcctgt
    18181 cgagtggggc cgaacgggaa acgagctgtg agccggctca cacgggaggg tgaaataacc
    18241 ggggagggaa tccccgtttg catcagagtc ccgcgaaccg gggaccggct ccccgtttgg
    18301 ggccgaccgc ccggacgcgg accgtacgca catcagcgcc agagcccgac ccagagccag
    18361 gaggcccgcg gaatgaagag ccccaccacc acaccggcgg ctcctgccct cgccgttccc
    18421 aagccgcgcg ccgacgccgt ccgcaaccgc gagcggatcc tggtcgcggc ccgcgagatg
    18481 ctcgtggagt ccggtgtcga ggccccgctc gacgagatcg cccgccgggc cggggtcggc
    18541 aacgccaccc tctaccggca cttccccgac cgggcggccc tcgtccacca cgtcgtgctc
    18601 ttcgtgacgg accgggtcag cgcccacgcc gagcgcgccc tggccgagga gcccgacgcc
    18661 ttcgccgcgc tgcgccgctt cacgcacgcc gccgcggacg agcggatcgg cgccctgtgc
    18721 cccatgctcg ccgacgactt cgaccgcgag caccccgaac tcctcgcgtc ccgcgacgcc
    18781 ttggaagagg cggtccaggc gctgctggcc gccggccagg acagcgggct ggtccgcgcc
    18841 gacatcggcg tcggtgacct gatgatggcg ctgtcccagc tcagccgccc gctgcccggc
    18901 acggcgtgcc tgcaggtgga ccgcttcgta caccgtcacc tcgggctgtt cctcgacggg
    18961 ttgcgggccc cggcccgctc ggaactgccc ggcgaggcgg tcacgctcga cgtcctgaga
    19021 cggaaaacca tgtgacgccc cgggtcgcgc ccgctagcgt cgaaaacctt ccctaaacct
    19081 gatttttcag tcattccgca cagtgagtgg gtattcccat gccaaaaaca gccgcgacct
    19141 cgccgctggc tgccgacccc agccgctgga aggcactcgt cttcatagcc ctggcccagc
    19201 tgatggtcgt gctcgacgcg accatcgtga acatcgccct gccctccgcc cagagtgatc
    19261 tgggcatctc ggacggcaac cgccagtggg tcatcaccgc gtacgcgctg gccttcggcg
    19321 gactgctcct cttcggcggc cgcatcgccg acaagtgggg ccgcaagaac gccttcatcg
    19381 tcggcctcat cggcttcgcc ctggcctccg cgctcggcgg cgcagccaac ggcgaggcga
    19441 tgatgctcgg tgcccgtggc ctccagggcg ccttcggtgc gctgctcgcc ccggccgcgc
    19501 tctccctgct ggccgtcatg ttcaccgacg ccacggagcg cgccaaggcc ttcggcatct
    19561 acggcgcgat cgccggtggc ggtggcgcgg tcggcctgat cctcggcggt ttcctcaccg
    19621 agtacctgaa ctggcgctgg accttcttcg tcaacatccc gttcgcgatc gtcgcggccg
    19681 tgggtgcctg gctggtcatc cgtgagcccg cccacggccg caaccgcgcg ccgctggaca
    19741 tccccggcgt ggtcctgtcc acgctcggcc tcgtcgcgct ggtctacggc ttcacccgcg
    19801 ccgagtcggc cggctggtcc gacgcggtca cggtgggcat gttcgtcgcc tccgccgtgc
    19861 tgctcgcggc gttcgtgttc gtcgagtccc gcgtgaagtc cccgctgctg ccgctgcgcg
    19921 tcctgctgga gcgcaaccgc ggcggggtct acctctcgct gggtctggcc gtcatcgcga
    19981 tgttcggcct gttcctcttc ctgacgtact acctccaggt cgtgaagggc ttctcgcccg
    20041 tcaagaccgg cttcgccttc ctgccgatga tcgcgggcat gatcacgggc tccacccaga
    20101 tcggcgcccg gctgatgacc cgggtcgcgc cgcggctgct gatgggcccg ggcttcctgc
    20161 tcgccgccgt cggcatgctg ctgctgaccc agctggaggt cggatcctcc tacccggcgc
    20221 tgatcctgcc ggcgcagctg ctgctcggcc tcggcatggg tacggccttc atgccggcca
    20281 tgtccctggc cacgcacggg gtgaacccgg ccgacgccgg tgtggcctcc gcgatggtca
    20341 acacctcgca gcaggtgggc ggcgcgatcg gcaccgccct gctgaacacg atcgccgcct
    20401 cggcgacgac cgcgtacctg accgaccacg cggccgaggc cgcggcgggc ggcccggcag
    20461 cgaagctggt ccaggcgcag gccatggtgg agggctactc ctccgccatc tggtgggccg
    20521 tcggcatcct ggccgccagc tcggccatcg ccctcaccct gatcaacacg gggcgtccgg
    20581 gcacgggcgg cccggtggcc tccggtgacg gcgagggcgc cgaggccgag gccgcggtca
    20641 agatcccggt gatcgcccac tgacggcgcc gccgcgcgtg cgggaatgac tgacgacccc
    20701 gcttcgttca aatttgaacg aagcggggtc ggtcttttcc gtgacgccgc cccaccgccg
    20761 gaggagcccc cgtgtccgcc accacccgca taccggtcct gtacctgagc cacggcgcgc
    20821 ccccgctggc cgacgacccg ctctggccgg gcgaactcgc cgcctggtcg gcggacctgc
    20881 cgcgaccccg ggcgatcctg atggtctccg cgcactggga agaggccccg ctcgccctcg
    20941 gcgccaccga gcgcgtcccg ctcctccacg acttccgggg cttccccgag cactactacc
    21001 gggtgcgcta cgacgccccg ggcgcccccg cgctggccgc gtcggtacgg ggactgctgc
    21061 gggcccccgg caccccggtc caggacgtcc cggaccgcgg cctcgaccac ggggcctacg
    21121 tccccctggt ggagatgtac ccgcgggcgg acgtcccggt gctgcagatc tccctgccca
    21181 cgctggaccc ggcccgcctg atggccatcg gccgcaagct ggccccgctg cgcgacgagg
    21241 gcgtcctgat cgtcgggagc ggcttcttca cccacaacct ggcggcgctg cgccaccggg
    21301 gcccgggcgt ccccgcgtgg tcggcggagt tcgacgcgtg gggccgcgag gcgctggccg
    21361 cctcggacgt ggacgccctg ctggacttcg agcgcaagtc cccggccggc cgcctggccc
    21421 acccccgtac ggaacacttc gccccgctct tcgtcaccct cggcgcggcc ggccccgacc
    21481 tcgccgcccc ccgtaccccg gtggacggct tctggctggg cctgtccaag cgctccctcc
    21541 agttcggctg accgcgccta gccctccgcg gctgcccggc cccggtgatg tcctcgccga
    21601 tgacgaaccc cttcgcgggt ccctcgggca cggtgacggc ggccccgtac gcggcccgga
    21661 cctcgtcgcc gtagatcgcc ttctcccggt ccggcctgct gaggacggtg acggtgccgc
    21721 cgtcgtcgta gtcgtcgatg agcacgtaga ccggaatccc ggcgcgggcg tacgcgcggc
    21781 gcttgcgggt ccggtcgcga gtgatgctgt cgctgccggg cgagacgacc tcgacgacga
    21841 gccgcacggc ctcggccctg atgccgatcc cgtcctcggt gccttgctcc ggtccgtcgc
    21901 cggaggtgac gacgacgtcg ggatgccacg cccgccgccc gtggatcacg taaacgcact
    21961 ggagtgcgtg gggcctgctc ccggccatgg cgctgtccag ggccttccgc agtcggttgg
    22021 cgatccccgt gtgccgcaag cggctcgtgg gtgagacctc gacgcatcct tcgacgatct
    22081 cggcgcggaa gccttcgggg agtgccgaaa cggcaccccg ccaggccagc catagggcgt
    22141 ggtcgggagt ggggcgatca cgtcgtgtca tgcggcgacg ctaggagtgc gcccacctat
    22201 gccctcgggg tatgccgccg gctcacccgg acgggtggtg cggggtcggg cgaaaaggga
    22261 tggatgctgg ttttccgggt actcgatcgt cagtccaggc aaccggaggg cggccggggt
    22321 cgtcttccgg ggcggagtgc aggcaggggc ggtgggccgc gcgtgtgatc gcggtctcaa
    22381 cgttgtggaa gttgtaaaag tccacgaggt gcgccgcgcc ccccgggaaa cccggcctga
    22441 cctgcacctc ttcgagattt ccgggctacg gtccccgtta cggtcggggg tcggcggggc
    22501 aggatactgc aagatctcga aaacgaggga ccggcgcggg aattctgtcc cgattccagt
    22561 cgttgtttcc ttcggaagcg ggcactcggg agagtgtccg aagacaccag cagcagacac
    22621 cagccgcacg caccgcgacc gaacacttcg caagggagca cgcatggcaa cccgcgccgt
    22681 cgcccgtcgt cagtccagca gcagcgcccg cgctgtgggc ggggagatcg ccgaccgcga
    22741 cctggtcggc atgtacctgg acgagatcgc gcgcaccccg ctgctcgacg ccgccaagga
    22801 agtagagctc tcccagatca tcgaggcggg cgtgtacgcc cggcagatcc tcgacggcga
    22861 ggcggagcgc gagggcgagg cgcccgcgcg cgaggagctc gaagcgctcg ccgccgaggg
    22921 ggagcgggcc aaggaagtct tcatccgctc caacctgcgc ctggtcgtcg cggtcgcccg
    22981 ccgctacccg cgcagcggtc tgcccctgct cgacctgatc caggagggca acgcgggcct
    23041 ggtgcgggcc gtcgagaagt tcgactacgc caagggcttc aagttctcca cgtacgcgac
    23101 gtggtggatc cgccaggcca tcacccgctc catcgccgac cagtcccgga cgatccgcct
    23161 ccccgtccac ctggtcgagg agctcggccg gatccgccgg gtgcagcgcg agttcaaccg
    23221 cgagcacgga cgcgacccgg agcacgcgga gatcgccgcc gagctggaca ccacggcgaa
    23281 gcgcgtgggc gacgtcctgg actgggcgcg cgacccggtc agcctgaaca tgtccgtcga
    23341 cgacgacggc gacacgcagt tcggtgacct cctggaggac acctcggcga tctcgccgga
    23401 gcagtccgtc ctctcgctgc tgcgcagcga ggagctggag gacctgctgg gcaagctcga
    23461 ccagcgcacg gcctcgatca tcaagatgcg ctacggcatc gacgacggcc gcgagcggac
    23521 cctcacggag gtcggcaagc agcacggcct gacccgcgag cggatccgcc agatcgagaa
    23581 gcacgccctg ctggagctga agaagatggc ccgcgacacc ggcttcgacg ccgtggcctg
    23641 acgcgccccc ccccgtacga gcccccggtg cctatccccc ccaggcgccg ggggctctct
    23701 ccctacccag gacccggctc gggatcgggc cccggccccg cacccgggcc cgccgccgcc
    23761 gtgaggcggg cggccagcgc ggcggccgcg gcgacgagga agtccggccc gcgcacggtg
    23821 aacggcaggc ccgtcagcgc cacccgcgcg accagccact ccggcgagtc cccgctgggg
    23881 aaccgcaccc ggcagccgcc ctcctccgcc accgccgccc cccgcagcca cgccggcagc
    23941 tcctgcgccg tcaccccggc gaacgccagg tccacctcgt acgcctgtcc gccccgcagg
    24001 gcccgcgcca ccatcgccgc cgcgtccatc ggcggctccc gcggcgtgaa cctcgccccc
    24061 gtcgcgaacg cctcggcgac ccggtcgacc cggaaggtcc gccagtcctc ccgctccagg
    24121 tcgtaggcca ccaggtacca gcggctgcgc gcgctcacca gccggtacgg ctccaccagc
    24181 cgccgcgagg gcgccccgtc ccgcgcccgg tacgcgaacc gcagccgctc cggccccgcc
    24241 accgccgagg ccatcgtcgt cagcgtccgc gggtccacgc tcggcccgtc gccccgggtc
    24301 agcgcgaccg tcgccgactg cagcgcgccc acccggtgcc gcagccgccc cggaagcacc
    24361 tgctccagct tcgcgagcgc ccgtacggac gcctcctcca cgccctcgat cgcgtgcccg
    24421 gcgcccgccc gcaggcccac cgcgatcgcc acggcctcct cgtcgtccag caccagcggc
    24481 ggcatcgccg cccccgcgac cagccggtat ccgccgtccg cgcccagcgt ggcctccacc
    24541 gggtacccga gctcccgcag ccggtcgatg tcccgccgga tcgtccgcgc gctcacccgc
    24601 agccgcgccg ccagctcgct ccccggccat t
//
