LOCUS       NZ_BMVE01000004        24570 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000004
VERSION     NZ_BMVE01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 635780)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 360466
            Orig. end                         :: 385036
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24570
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24570
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24570
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14570](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14570)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            159..1667
                     /locus_tag="IE248_RS14980"
                     /old_locus_tag="GCM10010336_30260"
     CDS             159..1667
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (91-473). E-value:
                     2.1e-23. Score: 75.1. Matches aSDomain:
                     nrpspksdomains_IE248_RS14980_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019992528.1"
                     /locus_tag="IE248_RS14980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30260"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190030929.1"
                     /sec_met_domain="PF00561 (E-value: 7.4e-27, bitscore: 89.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTYRRKAALLALSVVSVATALTGAGAPLARAAPGAPASSLEWKP
                     CARPGGPAAQECAELPVPLDYADPDGPRITLAVSRLRSDRPAARRGTLLVIPGGPGGSG
                     VQRLTQKGNALSRELAGAYDIVALDPRGVGGSTKASCGLDPADRWLVTLRSWAGPDGET
                     AENAARARRIADACAREGGPVLRSFTTANEVRDIDRFRQALGERKLSAWGVSYGTYVGA
                     VYAQTYPDRTDRWVLDSSGDPDPRRLARGWLANMSQGADDRFPDFAAWAADPARDAEGL
                     RLAEHPEQVEPLFLELAARLDREPKESDVAGTPLTGNGLRQALQNALYGDALFPGLARL
                     VRAAQDPAARPTLPPELARPLPDTDAAVMVGVICNDVRWPQGAAGYEEAVAADRAAHPL
                     TAGMPVNVTPCSFWKDRPREEPTRITDRGPSNILMIQNLRDPSTPYFGALKMRRALGDR
                     ARLVTVDHGGHGVYLAGTNTCGDRAVTHYLTTGTRPHQDTYCAP"
     aSDomain        432..1577
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS14980_Abhydrolase_1.1"
                     /evalue="2.10E-23"
                     /label="IE248_RS14980_Abhydrolase_1.1"
                     /locus_tag="IE248_RS14980"
                     /protein_end="473"
                     /protein_start="91"
                     /score="75.1"
                     /tool="antismash"
                     /translation="TLLVIPGGPGGSGVQRLTQKGNALSRELAGAYDIVALDPRGVGGS
                     TKASCGLDPADRWLVTLRSWAGPDGETAENAARARRIADACAREGGPVLRSFTTANEVR
                     DIDRFRQALGERKLSAWGVSYGTYVGAVYAQTYPDRTDRWVLDSSGDPDPRRLARGWLA
                     NMSQGADDRFPDFAAWAADPARDAEGLRLAEHPEQVEPLFLELAARLDREPKESDVAGT
                     PLTGNGLRQALQNALYGDALFPGLARLVRAAQDPAARPTLPPELARPLPDTDAAVMVGV
                     ICNDVRWPQGAAGYEEAVAADRAAHPLTAGMPVNVTPCSFWKDRPREEPTRITDRGPSN
                     ILMIQNLRDPSTPYFGALKMRRALGDRARLVTVDHGGHGVYL"
     misc_feature    complement(1702..1716)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.42"
                     /tool="antismash"
     gene            1707..2561
                     /locus_tag="IE248_RS14985"
                     /old_locus_tag="GCM10010336_30270"
     CDS             1707..2561
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958324.1"
                     /locus_tag="IE248_RS14985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30270"
                     /product="immunity 49 family protein"
                     /protein_id="WP_190031035.1"
                     /transl_table=11
                     /translation="MTVARHIVAGPDAAAFAERLSKQVAGHIDRLETSADSIDFAFSTA
                     LLALQAHCVADPEAANLETWAATVNAMQLGTALFAVTGASEGTVECRINGRVRTIPVIG
                     PQPYADAGNWLLAFWLSVICREQERMTQLCRIPLEQLRSPGGEYEEFFYHWVDAQRTYW
                     LRGAGLVEKLIAAIETSDPEVAHTVPRDMLQGLLYPPINLFRHFVRGHEEGFSPALVEA
                     LNLHRAYWTRNEERAADIDGAVALGPLAMACLAYDGKLPIGVESDFVPKYLLEHGWLGE
                     FPT"
     gene            2582..3448
                     /locus_tag="IE248_RS14990"
                     /old_locus_tag="GCM10010336_30280"
     CDS             2582..3448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718121.1"
                     /locus_tag="IE248_RS14990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30280"
                     /product="immunity 49 family protein"
                     /protein_id="WP_190030930.1"
                     /transl_table=11
                     /translation="MAARIARHEFATDNVAEAMAPVVESAEEALAGLATSEDDRYDALT
                     LALAAAKWHCLADPVADRFTTWEAWILAMQAGSALFAAGRATEGTVTCRIGVNGEEREL
                     PATGPQEYLHAGNWITSFYLAAICRENDRVQQLVQVPLDFLRASGAEFDDYLYAWIETI
                     QNHWFGRQETWETLVRAVDGTDPANVRIAGKELMLKILYPPINLFYRYVTRDNTLFNEA
                     LVEALTWHKEYWTANDARSRSGEGLVALGPLAIACMARDAGMPIEVESAYLPKELLEFG
                     WVGEVDA"
     misc_feature    3963..3977
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            4115..>4693
                     /locus_tag="IE248_RS38565"
                     /pseudo=""
     CDS             4115..>4693
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="IE248_RS38565"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAREMHDTVSYHLGLIAAQSGALWSTAPDDTVREDAETIRRHSAD
                     ALAELRDIVGVLRHAAGRGDEGDSARLANLGELVREARLDAVLDLDLGLPDGRGCGPEV
                     EQAAYRTVQEALTNVRKYAPGSRIDIRVGPSATGDALLVEVRNGPVPDPPAGGAGGGFG
                     LTGLAERTALVGGTFRAGATADGGFAVRAE"
     gene            complement(4705..5472)
                     /locus_tag="IE248_RS14995"
     CDS             complement(4705..5472)
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980774.1"
                     /locus_tag="IE248_RS14995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_190030931.1"
                     /transl_table=11
                     /translation="MTTTLGNALYDQKLASVYDRMYPIGHDTEQAVAFVAALTPPGGSV
                     LELGVGTGRIAVPLAGDGFTVHGIDGSEPMLAELRARDPQGTVTTRLGDFTREGTGRTF
                     DTVTLVLNTFFVAVTKEQQVGCLRLAREQLAPGGRFVLEAFDPAPYHHMEKPDHSMRHL
                     DERSIMLDTLTVDRSQQLMLSTHTIIDGGAPETREHLLRYAFPFEIDLLAELSGLRLVE
                     RTEDWAGTPYTSSSLRHVSVYEADPDSPWGDCR"
     gene            complement(5571..6401)
                     /locus_tag="IE248_RS15000"
                     /old_locus_tag="GCM10010336_30300"
     CDS             complement(5571..6401)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="IE248_RS15000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30300"
                     /product="response regulator transcription factor"
                     /protein_id="WP_229895328.1"
                     /transl_table=11
                     /translation="MIVDDEVLLRSCMQRILESEPDIDVPVACDGPAALGAIELHRPDV
                     VLLDLRMPEVDGFAVLAGLGALTDPPAVAILTTFLADEDIAAALGSGAKGFLLKDATPQ
                     ELVHAVRVLASGGTVLSPQAARIVVGGYLGTGPSYGGGPSYGGGPSYLSGGPGYDEPDP
                     GLSAGLDAGLDPGLDAGLEARLDSLTDRERQVLDLLAGGLTNADIGRRLLLSASTTKEH
                     VSAILAKLGLTNRVQAAVVATHRATHRTGHRTTYRAAPPPGRPRPPALAGTGTR"
     misc_feature    complement(6519..6534)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            complement(6551..6952)
                     /locus_tag="IE248_RS15005"
                     /old_locus_tag="GCM10010336_30310"
     CDS             complement(6551..6952)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS15005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_30310"
                     /product="hypothetical protein"
                     /protein_id="WP_037797913.1"
                     /transl_table=11
                     /translation="MLLLEFALHSLMDLTLWIGGKGLDRARCARRVAAFRRGEPVTLRC
                     RYRTGAAAGRASGMQPGKLTLGRSGAVLDGPGASALRLAGPAVAATGGGRGGTALTCTT
                     AQGEKAELLVLTWDSAMVALIEESIEAGA"
     gene            complement(7015..8058)
                     /locus_tag="IE248_RS15010"
                     /old_locus_tag="GCM10010336_30320"
     CDS             complement(7015..8058)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324900.1"
                     /locus_tag="IE248_RS15010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30320"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_229895329.1"
                     /transl_table=11
                     /translation="MTPAPPVMTPLSLMYPLMASDLDELAAFGETVRDLALERLYLGQS
                     LVVDTHQAFAHLAGRGIRVPAGTSVALTALRHPLDAAVQARSVALLTGRPVVAGFGAGD
                     PDFVAALRGEPYESPLTAVAEYLSVVRRLLDGEAVEDFRGRYVRLDGGPLPLPHTAAAA
                     PCPRVSLGVGVLRPRMAHTAGQIADVAITLLTPAGHLREAIVPALARGAGSRGRPVPGV
                     TAIVPCAVRRPGRDPRKLAFAAHAPHLSGEHYAAMLRSAGLDVDVSDPWAGAGALVDGG
                     VFAYGTPEEVAAQLTGYGEAGATEIALSCAGVLLTEGPEAALADVRAIVEAVRDRAGRP
                     APVTRIP"
     gene            complement(8127..10004)
                     /locus_tag="IE248_RS38175"
                     /old_locus_tag="GCM10010336_30330"
     CDS             complement(8127..10004)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741466.1"
                     /locus_tag="IE248_RS38175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30330"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190030934.1"
                     /transl_table=11
                     /translation="MSAEQTQTQTQAQTHRRLSRDLRYWWLVLRSFRGLSPLRVSALTL
                     LTLLTAAVPAAGIWLTADAVQAVADAVEGVPGAGDRLTRAAAGLVAVAVGEHVLSSVAQ
                     YLNSLLQLEFGAAIGEQVMVKGTRMDLGSYEDPEAYDRLQRALRESGGGTAFEVFEEML
                     RTLTSLASLVMVSSVLFSWNAWLAVVILLAPVPALAAHIVFSKEGYAVEYHRAQDRRRA
                     FYYQDLTTTDSSYKEVKLYQLGPYLVDRYRALVQEFFRVDRGLARRRHGWSAVLGLVSV
                     AGSAGALVFALKSTVSTGRLGELAGYLQALGAVHVAAGGLLLGVATLYQNTLFTGNLFD
                     YLSLPEGSVTGGTRPFPRRLTHGIEFQDVTFRYPGTETVALDRFSCFVPAGTCCALVGA
                     NGAGKSTVVKLLTRLYEPTSGRILIDGVPIEEYDTTDLQRNIGVVFQDFIRYEMPVRHN
                     IGFGRVEELDDTDRIRAAAAASGADAFVDGFEATYDTVLGRHFEGGRQLSGGQWQKIAL
                     ARAFLRDAPIAILDEPTAAIDPEAEADIFGRLRTICSRATSLVVSHRFSTVRVADKILV
                     LDGGSLIEEGTHGELLALGGTYARLFRLQADAYLTPSGAGPAERSGDLV"
     gene            complement(10001..13243)
                     /locus_tag="IE248_RS15020"
                     /old_locus_tag="GCM10010336_30340"
     CDS             complement(10001..13243)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980835.1"
                     /locus_tag="IE248_RS15020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30340"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_190030935.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.6e-153,
                     bitscore: 507.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.4e-14,
                     bitscore: 49.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.3e-34, bitscore:
                     114.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRYHALDFHLLRAPALPVGVWRDALDGADRERTRARLLRALADD
                     PRVRHGLVAAGSGLLDGLAKLDGSAPGSGSGSGSGSGSGSGKEARRVHSRALRYLTRMS
                     TRPTPFGAFSGVALGTFGDTTTARLGATALGEAHVRADTAWLLALVQRLEEDPQSLARL
                     GVSVNAMAHRVGDRLVLPSSGVHGDASDRRAVRVRHTAPLARIRALAPPAAPVPYATLV
                     TELAEEFPAAGRERISAFVAELVGLGLLVTDLRPPVTEPRPEAYVLDRLTAAGVDHPAV
                     AALREIVGLTGRAPYGDTDALRRLRAAQRALVPLHKGQPSQVDSALDLAAPALNRQIAA
                     EVAEAVGCLAELGRAAPAGYDHLGAYHQAFMERYGSDALVPVLDLLGAERGLDAPGGYL
                     TPPRAMALNQPVAEDDPHTARALVALAADAWRRGAGEVELTDEVLRRLLPPDAANAANA
                     ANSAGLSGRPDCPGLDAYVQIAADGPEAIDRGEWRAVLNPDGLGEGGRTFGRFGHLLGA
                     DATDRLRAYARAREALEPDVVVAELAYLPANGRGANVAIRPAVHAYEIPVNVAPTAAPE
                     QVIDLADIHVGAADEGLRLYSARLGRELVVVQNHMLSPYGAPNVCRFLLEVSRARYATP
                     AGFGWGPVEGAPHLPRVVRGRVVVRAAEWNLYPAGAQAAPAAGGPVPVPRSADEVARWR
                     RDWGVPRYVYLADDDNRLLLDLDHPLCVDELLAELGGGAGSGSGRVTLHEALPGPDSAW
                     LRDGSGRGHLSEVVIPLIATGAREAARESGPGLAPEEIRRKAAPSAHPAHLPGSSWSYL
                     KLYAARDLHDEIAATELPALLPQLREAGADPDRWFYIRYADPDAHLRIRVRTAAPAAAL
                     PALLAWGEGLVRRGLAERLEVATYHPEISRYGGPAVHDAVEELFAANSDVSCRLLRLLW
                     DEEEPGLEPEAVVIAAVDALYAQWGLGIRERLAAMPRPAQDTEARERYRKDRDYLCELL
                     QPWERRPHPLGRAHHERLAAVLDAQAPAVRRAALAVARAEAAGTLWGGRDAILASLAHM
                     QVNRLLPMDRPAENRCYLVWGHVLNCLRGRPQ"
     aSDomain        complement(12473..12751)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE248_RS15020_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.90E-16"
                     /identifier="RREFam001.1"
                     /label="IE248_RS15020"
                     /locus_tag="IE248_RS15020"
                     /protein_end="257"
                     /protein_start="164"
                     /score="49.7"
                     /tool="antismash"
                     /translation="VSVNAMAHRVGDRLVLPSSGVHGDASDRRAVRVRHTAPLARIRAL
                     APPAAPVPYATLVTELAEEFPAAGRERISAFVAELVGLGLLVTDLRPP"
     gene            complement(13308..14570)
                     /locus_tag="IE248_RS15025"
                     /old_locus_tag="GCM10010336_30350"
     CDS             complement(13308..14570)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="IE248_RS15025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30350"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_190030936.1"
                     /sec_met_domain="LANC_like (E-value: 2.7e-33, bitscore:
                     110.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVPPLPAGLAARAEAVAGLIAERLDTPARADAAAVRAARQSDV
                     SFWAGASLSEGHAGLALLHRHAAGREEGQGRARAFTRAAFAATGQSPLHHPGLFDGTAG
                     LAFALQDVSRDEPRFLPSLGRLHEQLARQVIDADWPRVPGAVADHHYDLVYGAAGIAVQ
                     LCAAAPATPLVEEALERCLRHLVWVAADGNWAVGGRLDTGMAHGAAGIAAALAAAWRRD
                     RRVPGQRAAMEELTGWLLAVGDGGTGPGRGGSGAGVAGGAGGLRWSRVVPADGGETAPA
                     WCHGTGGVAAGLLAVARATGDPGLEARAFAALDGLLDRVADGDVPRSPTVCHGLAGIAA
                     LAHEFAAHGSAGAARALPGLTLRLVDAADPGLPLLYRDHETTGHVVDNPGLLTGAAGIA
                     LTLRALATGHRPGWWSVLFPR"
     gene            complement(14717..14899)
                     /locus_tag="IE248_RS15030"
                     /old_locus_tag="GCM10010336_30360"
     CDS             complement(14717..14899)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS15030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_30360"
                     /product="hypothetical protein"
                     /protein_id="WP_037793209.1"
                     /transl_table=11
                     /translation="MDEFHLDARVTVSADPAETQLSPAASIASRIVSKAVVKQTIKQTI
                     KMTAACAAVRTNGKC"
     misc_feature    complement(14975..14991)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    15017..15031
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.19"
                     /tool="antismash"
     gene            complement(15065..15649)
                     /locus_tag="IE248_RS15035"
                     /old_locus_tag="GCM10010336_30370"
     CDS             complement(15065..15649)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007498591.1"
                     /locus_tag="IE248_RS15035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30370"
                     /product="hypothetical protein"
                     /protein_id="WP_073797831.1"
                     /transl_table=11
                     /translation="MEHLNEYLMTQKITPLVNRYTVTTPDGGQVLAFAEQKRLALKEEL
                     TLWSGEDRTRRLGGFKARQVIDFGATYDVSRPDGATIGTFRKDVKASLIRSTWHLTQGD
                     EAAAVGKERRLGVALARRGWELLDLVVPVIPVPPVPFVYHFDFVREDKPVLSVERKWGI
                     RDRYVIRVQDPSLDRVLALCMAVGLDALQSR"
     gene            complement(15756..16436)
                     /locus_tag="IE248_RS15040"
                     /old_locus_tag="GCM10010336_30380"
     CDS             complement(15756..16436)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741461.1"
                     /locus_tag="IE248_RS15040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30380"
                     /product="cytochrome b/b6 domain-containing protein"
                     /protein_id="WP_190030937.1"
                     /transl_table=11
                     /translation="MTSTPGSAGPTAAATPPPSEPGARVRRFSRAERWTHRTTAALVLL
                     CVATAAALYVPQVAELVGRRELVVTVHEWAGILLPAPFLLGLGSPAFRADLRRLNRFGP
                     HDRTWLRAARRRDRRRASRPAGKFNAGQKLYASWIAGAALVMLATGLLMWFTHLAPLVW
                     RTSATFVHDWLALAIGVVLAGHIGRALADPEARRGMRTGSVARSWAAREHPLWLDAGSG
                     RGDG"
     gene            complement(16378..17043)
                     /locus_tag="IE248_RS15045"
                     /old_locus_tag="GCM10010336_30390"
     CDS             complement(16378..17043)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576522.1"
                     /locus_tag="IE248_RS15045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30390"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_229895354.1"
                     /transl_table=11
                     /translation="MLGLGAGGLVAAPYVQRGTEALLGAASDTDPTGLTGLLPNGGGFR
                     YYSVASSVPRRPEGDYRLTVDGLVERPATYGLDALRALPQTRVVRDVQCVTGWRVPATA
                     FSGVRLSLLLDAAGVRPGARAIRFTCFDGAYSESLTLPQARRDDVLVCLRMRDEPVSHA
                     HGGPVRLYVAPMYFYKSAKWISGITVTSEVRPGYWEERGYDVDAWVGRSNGRGDAPTV"
     gene            complement(17170..18012)
                     /locus_tag="IE248_RS15050"
                     /old_locus_tag="GCM10010336_30400"
     CDS             complement(17170..18012)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012415.5"
                     /locus_tag="IE248_RS15050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30400"
                     /product="CAP domain-containing protein"
                     /protein_id="WP_190030939.1"
                     /transl_table=11
                     /translation="MQDHDREDRLGRVGRGHRKRRRKAPVLAAAAAVVLLAGGGGAYAL
                     LSGAAPERTAVAVAGAPSAPSAPSALAGRPDPVVGGGAVPAPTSTGTVSSSPRPVASVT
                     ATPAATRPRASASASAHARPSKAAASPASGPAGPDPKVPGDRTSTQDVRTAQSLSLQLL
                     NAERAAVGRPPLALRQDLSDFARKWAEHMRTSGFSHSSSEERAYLKTGTRTWTGENIVW
                     FSDASMTAQEAAEKFQSMWRHSPGHYKAQVSPDFTEVGVGLHHDSSGWWGVHNFSDGR"
     misc_feature    18138..18153
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     misc_feature    18147..18163
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.45"
                     /tool="antismash"
     gene            18278..18481
                     /locus_tag="IE248_RS15055"
                     /old_locus_tag="GCM10010336_30410"
     CDS             18278..18481
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741458.1"
                     /locus_tag="IE248_RS15055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30410"
                     /product="DUF6243 family protein"
                     /protein_id="WP_073797835.1"
                     /transl_table=11
                     /translation="MTDSKNINNPVGQGGGQRKKLSRAERQNNGPHRNLDRKGAADQKA
                     ELIRKMREKTAAPEQPNTPTQT"
     gene            18812..19291
                     /locus_tag="IE248_RS15060"
                     /old_locus_tag="GCM10010336_30420"
     CDS             18812..19291
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018517965.1"
                     /locus_tag="IE248_RS15060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30420"
                     /product="hypothetical protein"
                     /protein_id="WP_190030940.1"
                     /transl_table=11
                     /translation="MTAIERLWGDFELPIKDALHYANGHSYDVALDSAAPTGFTVLTPF
                     DLAGTLEGDPSWVSSVDGLAAVDLGEKGLLWGGEGSHGSEGFIARLTVDRALTWAMFFT
                     ESNPFDRIRLSGNVATFSSTSGLEIELDIDDPRTPIPEPGPTAARMTDTAADTSS"
     gene            complement(19823..21250)
                     /locus_tag="IE248_RS15065"
                     /old_locus_tag="GCM10010336_30430"
     CDS             complement(19823..21250)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100696.1"
                     /locus_tag="IE248_RS15065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_30430"
                     /product="DUF6177 family protein"
                     /protein_id="WP_190030941.1"
                     /transl_table=11
                     /translation="MTKDVIALTERMPDALSILAGLLAGGPDLTIGTTGEGAVIQLCDA
                     EGRPLVSIEAPLMLQVPGEAARLLGPGAEPSGDGPAWWIEARATTGLPQAEQLAGAFAA
                     RLTMLLGGRVWPPDAPGTIGAARPVDVAGITAVPVPAAAQPAVDMLTDEAAVVLQDRPV
                     VPMTSWLSEALRATVESDRSLQIVTPPHCRLSLPTRMLLQSLPSRWVVQDERCGYYDGL
                     TGAVLRWQDGAFCPDRDESGETPVADAFTEVRPTGERQLIVSFRTLHPPEADLVLGGGL
                     EAAYRALTGSPPAGWGTSEPAGLTWSRRQLTDLAYERAPQSTWTVVVGTPDRPAVATLR
                     VIRTAEGVEEDVTLTVGYGLGEQLPLEALPELAGELVTRHGLKTMICQLREARRDLSAP
                     PRFEHPPLPYAFVLGPAEVREAGRDTASRTPLRERPVQLGPSARPGYYYALGDGETAES
                     WTALEQLVRHLRGAPPL"
     misc_feature    complement(21454..21467)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.26"
                     /tool="antismash"
     misc_feature    21958..21973
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.62"
                     /tool="antismash"
     misc_feature    complement(23634..23648)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(24497..24512)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.27"
                     /tool="antismash"
ORIGIN
        1 accgcgcggc aggtcacgcg cacccgcccg cgggggcggt cgcgggtggt cgtaggtggg
       61 gtgggggctc gggtgggggc tcgggtgggg ctaacccccg gcgcccgtct gggggcagcc
      121 ggttgggcgg ctgacgacca ctcaacaacg atgtgggcat gcctacttac cgccgcaagg
      181 ccgctctcct cgccctgtcc gtcgtctccg tcgccacggc cctcaccggc gccggcgccc
      241 cgctcgcccg ggcggcgccc ggcgccccgg cgtcctccct ggagtggaag ccgtgcgccc
      301 ggcccggtgg ccccgccgcc caggaatgcg ccgagctccc cgtaccgctc gactacgcgg
      361 acccggacgg cccccggatc acgctcgccg tgtcccggct gcgcagcgac cggcccgccg
      421 cgcggcgcgg caccctgctg gtgatccccg gcggcccggg cggctccggc gtccagcgcc
      481 tgacccagaa ggggaacgcc ctgtcccggg agctggcggg cgcctacgac atcgtcgccc
      541 tggacccgcg cggcgtcggc ggctccacca aggcgagctg cggcctggac ccggcggacc
      601 ggtggctggt caccctccgc tcctgggccg gccccgacgg ggagaccgca gagaacgccg
      661 cccgggcccg ccggatcgcc gacgcctgcg cccgcgaggg gggcccggtg ctgcgcagct
      721 tcaccacggc caacgaggtc cgcgacatcg accgcttccg gcaggcgctg ggcgagcgga
      781 agctgtccgc gtggggcgtc tcgtacggca cctacgtggg cgccgtgtac gcgcagacct
      841 accccgaccg caccgaccgc tgggtcctgg acagcagcgg cgaccccgac ccgcggcgcc
      901 tggcccgcgg ctggctcgcg aacatgtccc agggcgccga cgaccgcttc ccggacttcg
      961 cggcctgggc ggccgacccg gcccgggacg ccgagggcct gcgcctggcc gaacaccccg
     1021 aacaggtcga gccgctgttc ctggaactcg ccgcgcgact ggaccgggag ccgaaggaat
     1081 ccgacgtcgc gggcaccccg ctgaccggca acgggctccg ccaggcgctc cagaacgccc
     1141 tctacggcga cgccctcttc ccggggctgg cccggctggt ccgcgcggcc caggacccgg
     1201 cggcccggcc gacgctcccg cccgagctgg cccggccgct gccggacacc gacgcggccg
     1261 tcatggtcgg cgtgatctgc aacgacgtgc gctggccgca gggcgccgcc gggtacgagg
     1321 aggccgtcgc cgcggaccgg gccgcgcacc ccctgacggc ggggatgccg gtgaacgtca
     1381 ccccgtgctc cttctggaag gaccggccgc gggaggaacc gacccggatc accgaccggg
     1441 gcccgtccaa catcctgatg atccagaacc tccgggaccc ctccaccccg tacttcggcg
     1501 cgctgaagat gcgccgtgcc ctcggcgacc gcgcccgcct ggtcaccgtc gaccacggcg
     1561 gccacggcgt ctacctcgcg ggcaccaaca cctgcggcga ccgcgccgtg acccactacc
     1621 tgaccacagg cacccgcccc caccaggaca cctactgcgc cccctgacac cggcgtagga
     1681 tcatcggcag ggggacttcc gtgaccatga ctgtcgcccg ccacatcgtg gccgggcccg
     1741 atgccgccgc gttcgccgag cggctgagca agcaagtggc cggccacatc gaccgccttg
     1801 aaacatctgc ggactcgatc gacttcgcgt tcagtactgc tcttctcgcc ctccaggccc
     1861 actgcgtggc cgacccggaa gcggcgaacc tggagacctg ggcagcgacg gtcaacgcga
     1921 tgcagctggg caccgcgctg ttcgccgtga ccggtgcgag cgagggaacg gtggagtgcc
     1981 gcatcaacgg gagagtgcgg accatccccg tgatcggtcc gcagccgtac gccgatgccg
     2041 ggaactggct gctggcgttc tggctgtccg tcatctgccg tgagcaggaa cggatgacgc
     2101 agctgtgccg gattccgctg gagcagttgc gttcacccgg gggcgagtac gaggagttct
     2161 tctaccactg ggtggatgcc cagcggacgt actggctccg cggggcgggc ctggtggaga
     2221 agctcatcgc ggcgatcgaa acgtccgatc ccgaagtggc gcacaccgtt ccgcgcgaca
     2281 tgctccaggg gctgttgtac ccgccgatca acctcttccg tcacttcgtg cggggccatg
     2341 aagagggctt cagcccggcc ctggtggagg ctttgaacct gcacagggcg tattggaccc
     2401 ggaacgagga gcgcgcggcg gacatcgacg gcgcggtggc cctggggccg ctcgccatgg
     2461 cgtgcctggc ctacgatggg aagctcccga tcggcgtgga gtcggatttc gtacccaagt
     2521 accttcttga gcacggctgg ctgggagaat ttcccacttg atcagctctg aggatgggcg
     2581 catggctgcg cgtattgccc gccacgagtt cgccacggac aacgtcgcgg aggccatggc
     2641 gccggtcgtc gagagtgccg aggaggcgct cgcggggctc gcgacctccg aggacgaccg
     2701 gtacgacgcg ctcacgctcg cgctggccgc agcgaagtgg cactgtctcg ccgaccccgt
     2761 cgcggaccgg ttcacgacct gggaggcgtg gatcctcgcc atgcaggccg gatccgcgct
     2821 gttcgcggcg ggccgggcca ccgagggcac cgtcacctgc cggatcgggg tcaacgggga
     2881 ggagcgggag ctgccggcga ccggcccgca ggagtacctg cacgccggga actggatcac
     2941 ctccttctac ctggccgcga tctgccgcga gaacgaccgg gtgcagcagc tcgtgcaggt
     3001 tccgctcgac ttcctgcgcg cttccggcgc ggagttcgac gactacctct atgcgtggat
     3061 cgagacgatc cagaaccact ggttcggccg tcaggagacc tgggagacgc tcgtccgggc
     3121 tgtcgacggc acggatcccg cgaacgtacg gatcgccggc aaggaactga tgctgaagat
     3181 cctctatccg ccgatcaacc tcttctaccg ctatgtgacg cgtgacaaca ccttgttcaa
     3241 tgaggctctg gtcgaggcgc tcacctggca caaggagtac tggacggcca acgatgcccg
     3301 ttcgaggagt ggtgaggggc tcgtcgcgct cgggccgctc gccattgcct gcatggcccg
     3361 cgatgccggc atgccgatcg aagtcgagtc cgcatacctg ccgaaagaac tgctggaatt
     3421 cggctgggtc ggcgaagtgg acgcctaggc cttttccctg atgggtgcgg gccgtggttg
     3481 tcagggggct cggggatact gcgagaggca agcagcggcc ccagacctgt gagacatgag
     3541 ggaacaccac atgagcacgg ccacgtccgg aaccgtcacg gcagcaccgc gcgcgtccgg
     3601 gggatggccg cgcagtgcgc tggccgggga cgtgctcatc accgccgtgg ccgccctgga
     3661 gctgctcacg ctgcacgggc agctcgaccg gaccgccgcg ctcgtgtgtc cgcccgcgct
     3721 gatcgcgctc atgctgcggc gccggctgcc cgtgacggtg ctgctggcga cgctgccgtc
     3781 gatggccacc gggttcctgt ggctcgcgcc catggcggcc atgtacaccg tcgcctcctg
     3841 cgccgtccgc cgccgggtgg tcgtgggcgc cggggcggcg ctgttcgcgg cgacgctgtg
     3901 ggccggctac accgtcgggg ccgcggccat gacctggagc gaccacctga tcgtcgtcca
     3961 ggtggcgctc atgttcagcc tcggccccgc cggtctgggc ctgctcgccc ggacccggtc
     4021 cgagctgcgg gcccacgtcg ccgagctgtc cgcgtcgcag gcgcgcggcc ggcgcctgga
     4081 ggccgagcgg gccgtcgccc gggagcgcac gcggatggcc cgcgagatgc acgacaccgt
     4141 ctcgtaccac ctcggcctca tcgccgccca gtccggggcg ctgtggagca ccgcccccga
     4201 cgacacggtc cgcgaggacg ccgagaccat acgccgccac agcgccgacg ccctggcgga
     4261 gctgcgcgac atcgtcggcg tcctgcgcca cgccgccggc cggggcgacg agggtgactc
     4321 cgcccggctg gccaacctgg gcgagctggt ccgcgaggcc cggctggacg cggtcctcga
     4381 cctcgacctc ggcctccccg acggccgcgg ctgcggcccg gaggtcgagc aggccgcgta
     4441 ccgcaccgtg caggaggccc tgaccaacgt ccgcaagtac gcccccggtt cccgcatcga
     4501 catccgcgtc gggccgtccg ccaccggcga cgccctcctc gtcgaggtcc gcaacggtcc
     4561 cgtcccggac cctcccgccg gcggcgccgg tggcggcttc ggcctcaccg gcctggccga
     4621 gcgcaccgcc ctcgtcggcg gcaccttccg cgcgggcgcc accgcggacg gcggcttcgc
     4681 cgtccgcgcc gaactgccgc tcggtcagcg gcagtcgccc cagggggagt ccggatccgc
     4741 ctcgtacacc gatacgtgcc gcaggctcga cgaggtgtac ggggtgcccg cccagtcctc
     4801 cgtacgctcc accagccgca gccccgacag ctcggccagc aggtcgatct cgaaggggaa
     4861 ggcgtagcgc agcaggtgct cccgggtctc cggggcgccg ccgtcgatga tcgtgtgggt
     4921 cgacagcatg agctgctgcg agcggtccac ggtcagcgtg tccagcatga tcgaccgctc
     4981 gtcgaggtgg cgcatggagt ggtccggctt ctccatgtgg tggtacgggg ccgggtcgaa
     5041 ggcctccagt acgaagcggc cgccgggagc cagctgctcg cgggccagcc gcaggcagcc
     5101 gacctgctgc tccttggtga cggccacgaa gaacgtgttc agcaccaggg tcacggtgtc
     5161 gaaggtccgc cccgtgccct cccgcgtgaa gtcgccgagc cgcgtggtca ccgtgccctg
     5221 cggatcccgc gcgcgcagct cggcgagcat gggctcggag ccgtcgatcc cgtgcaccgt
     5281 gaagccgtcc ccggcgagcg gtacggcgat ccggccggtg ccgacgccca gttcgaggac
     5341 gctgccgccg ggcggggtga gtgccgcgac gaacgcgacc gcctgctcgg tgtcgtggcc
     5401 gatcgggtac atgcggtcgt acacgctcgc cagcttctgg tcgtacaggg cgttgccgag
     5461 ggtcgtggtc atgcgggcgc tcactccaaa cggggtgccg gtggggcacg gtcggtacgg
     5521 ggccggcccc gccgccgccc ggccccggcc cacgggacct cggccgcgcc tcagcgggtg
     5581 ccggtgccgg ccagggccgg cggccgcggc cggcccggag ggggcgcggc gcggtaagtg
     5641 gtgcggtggc cggtgcggtg cgtggcgcga tgggtcgcga ccacggcggc ctgtacgcgg
     5701 ttggtcaggc ccagcttggc caggatggcg ctgacgtgct ccttggtcgt ggacgcgctc
     5761 agcagcagcc ggcggccgat gtcggcgttg gtcaggcccc ccgcgagcag gtccagcacc
     5821 tggcgctccc ggtcggtgag cgaatccagg cgggcttcca gcccggcgtc cagacccggg
     5881 tccaggccgg cgtccaggcc ggcgctcagc cccgggtccg gctcgtcgta ccccgggccg
     5941 ccgctgaggt acgagggccc gcccccgtat gacgggccgc ccccgtacga cggcccggtg
     6001 ccgaggtagc cgcccaccac gatccgggcc gcctgcggcg acagcaccgt gccgccggag
     6061 gccagcaccc gtaccgcgtg gacgagttcc tgcggcgtcg cgtccttgag caggaagccc
     6121 ttggccccgg agcccagcgc ggccgcgatg tcctcgtcgg ccaggaacgt cgtcaggatc
     6181 gccacggccg gcggatccgt cagcgcgccg agaccggcca ggacggcgaa gccgtccacc
     6241 tccggcatgc gcaggtcgag caacaccacg tccggacggt ggagttcgat cgcccccagc
     6301 gcggccgggc cgtcacaggc gaccggaacg tcgatgtccg gttcgctctc cagaatgcgc
     6361 tgcatgcacg agcgcagcag gacttcgtcg tcgacaatca ttacgcggat catcacgccc
     6421 ccttgtggcg gccaccccgt ttggccgcac ttcggccaag gtatcaaccg ggtgaaatgg
     6481 ggttgaagtc caggggtgcg gctgggggga aggcgaggta ccgcccaggg gaagcgctgc
     6541 cgcagcctgc tcaggcgccc gcttcgatcg actcctcgat gagcgcgacc atcgcggaat
     6601 cccaggtcag gaccagcagt tcggccttct caccctgcgc ggtcgtgcag gtcagggccg
     6661 ttccgccgcg gccaccgccg gtcgccgcca cggccggccc ggccagccgc agcgcgctgg
     6721 ccccggggcc gtccaggacc gctccggagc gccccagcgt gagcttcccg ggctgcatcc
     6781 cgctcgcccg gccggcggcg gcgcccgtac ggtaacggca ccgcagcgtc accggttcgc
     6841 cgcgccggaa cgcggcgacg cggcgcgcgc agcgggcccg gtcgaggccc ttgccgccta
     6901 tccacagcgt caggtccatc agggaatgca gcgcgaattc cagcagcagc atgtgatcgt
     6961 tcgctcctca actcagacga ctcggggatg acacgggcgg acacgggtca cgggtcatgg
     7021 gatacgggtc accggtgcgg gccgccccgc ccggtcgcgt accgcctcga cgatggcccg
     7081 tacgtcggcc agtgccgcct cggggccctc ggtcagcagg accccggcgc agctcagcgc
     7141 gatctccgtc gcccccgcct caccgtaacc ggtgagttgg gcggcgacct cctcaggtgt
     7201 cccgtacgcg aagacaccgc cgtcgaccag cgcgcccgcg cccgcccacg gatccgacac
     7261 gtccacgtcg agcccggccg agcgcagcat ggccgcgtag tgctccccgc tcaagtgcgg
     7321 tgcgtgcgcg gcgaacgcca gcttcctggg atcgcggccc ggcctgcgca ccgcgcacgg
     7381 cacgatcgcc gtcacccccg gcaccggccg cccgcgcgac ccggcgcccc tcgccagagc
     7441 cggcacgatc gcctccctca ggtgaccggc cggggtcagc agcgtgatcg ccacgtccgc
     7501 gatctgcccc gccgtgtgcg ccatccgcgg ccgcagcacg cccacgccga gtgacacccg
     7561 cgggcagggc gcggccgccg ccgtgtgcgg cagcggcagg ggtccgccgt cgagccgtac
     7621 gtagcgcccc cggaagtcct cgaccgcctc gccgtccagc agccgccgca ccacggacag
     7681 gtactcggcg acggccgtga gcgggctctc gtacggctcc ccgcgcagcg ccgccacgaa
     7741 gtccgggtcc ccggcgccga acccggccac caccggccgc ccggtcagca gcgccacgga
     7801 ccgcgcctgc acggccgcgt ccagggggtg gcgcagcgcg gtcagcgcga cgctggtccc
     7861 ggcgggcacc cggatgccgc gtcccgcgag gtgggcgaac gcctggtggg tgtcgacgac
     7921 cagcgactgg cccaggtaca ggcgctccag cgccaggtcc cgtacggtct cgccgaaggc
     7981 ggcgagctcg tcgaggtcgg aggccatcag cgggtacatc agggacagcg gcgtcatcac
     8041 gggcggcgcg ggcgtcacgg ggatcctctc cttggacatc ggggtcgtgg tcgggctcgg
     8101 gctcgggctc gggctcgggg gcgcggtcat acgaggtccc cggaccgttc ggcgggcccc
     8161 gcacccgacg gcgtcaggta cgcgtcggcc tggagccgga agagccgggc gtacgttcct
     8221 ccgagggcca ggagttcccc gtgcgtgccc tcctcgatga gcgagccgcc gtccagcacg
     8281 aggatcttgt ccgcgacccg gacggtcgag aaccggtgcg agaccaccag cgaggtggcc
     8341 cgggagcaga tcgtccgcag gcggccgaag atgtccgcct ccgcctccgg gtcgatcgcg
     8401 gcggtcggct cgtcgaggat cgcgatcggc gcgtcccgca ggaacgcccg ggccagcgcg
     8461 atcttctgcc actgcccgcc ggacagctgc cggccgccct cgaagtgccg gcccagcacg
     8521 gtgtcgtacg tcgcctcgaa cccgtcgacg aacgcgtcgg cgccgctcgc cgcggcggcc
     8581 gcgcggatgc ggtcggtgtc gtcgagctcc tcgacccgcc cgaagccgat gttgtggcgg
     8641 accggcatct cgtagcggat gaagtcctgg aagacgacgc cgatgttgcg ctggaggtcg
     8701 gtggtgtcgt actcctcgat cggcaccccg tcgatgagga tccggcccga ggtgggctcg
     8761 tagagcctgg tcagcagctt gacgaccgtg ctcttgccgg cgccgttcgc gccgacgagc
     8821 gcgcagcagg tgccggcggg gacgaagcag ctgaagcggt ccagggcgac ggtctcggtg
     8881 cccgggtagc ggaaggtgac gtcctggaac tcgatgccgt gggtgaggcg ccgcgggaac
     8941 ggccgggtgc cgccggtgac gctcccctcg ggcagtgaga ggtagtcgaa gaggttcccg
     9001 gtgaacaggg tgttctggta gagggtggcg acgccgagca gcagcccgcc ggctgccacg
     9061 tgcacggcgc cgagcgcctg gaggtagccg gcgagctcgc cgaggcggcc cgtcgagacg
     9121 gtcgacttga gggcgaagac cagggccccg gccgaaccgg ccacgctgac cagccccagg
     9181 accgccgacc agccgtgccg gcgccgcgcc aggccccggt ccacccggaa gaactcctgg
     9241 accagcgccc ggtagcggtc cacgaggtac gggccgagct ggtacagctt cacctccttg
     9301 taggaggagt ccgtcgtcgt caggtcctgg tagtagaagg cccggcggcg gtcctgcgcg
     9361 cggtggtact cgacggcgta cccctccttg ctgaacacga tgtgcgcggc gagcgcgggc
     9421 accggggcga gcaggatgac gaccgcgagc caggcgttcc acgagaacag caccgagctg
     9481 accatcacga gcgacgccag cgaggtgagc gtgcgcagca tctcctcgaa cacctcgaag
     9541 gccgtgccgc cgccgctctc gcgcagggcg cgctgcagcc ggtcgtaggc ctcggggtcc
     9601 tcgtacgagc cgaggtccat ccgggtgccc ttgaccatga cctgctcgcc gatcgcggcc
     9661 ccgaactcca gctggagcag ggagttcagg tactgcgcga ccgacgacag gacgtgctcg
     9721 ccgaccgcga ccgcgaccag cccggcggcg gcccgggtga gccggtcacc ggcgcccgga
     9781 acgccctcga cggcgtcggc gacggcctgc accgcgtcgg cggtgagcca gatcccggcg
     9841 gcggggacgg cggcggtcag cagggtgagc agcgtcaggg cgctcacccg cagcgggctg
     9901 agcccccgga aggagcgcag caccagccac cagtagcgca ggtcccggga gagccggcgg
     9961 tgtgtctgcg cctgcgtctg cgtctgcgtc tgctcggcgc tcactggggc ctcccgcgca
    10021 ggcagttcag tacgtggccc cacaccaggt agcagcggtt ctcggcgggc cggtccatcg
    10081 gcagcagccg gttcacctgc atgtgcgcga ggctcgccag gatggcgtcc cggccgcccc
    10141 acagggtccc ggcggcctcc gcccgggcga cggccagcgc ggcgcggcgt acggccgggg
    10201 cctgcgcgtc gaggacggcg gccagccgtt cgtggtgggc gcggccgagc gggtgcggcc
    10261 ggcgctccca gggctggagc agttcgcaca ggtagtcgcg gtccttgcgg taccgctcgc
    10321 gggcctccgt gtcctgcgcg gggcggggca tggcggccag ccgctcgcgg atgccgagcc
    10381 cccactgggc gtagagcgcg tccacggcgg cgatgaccac ggcctcgggt tccaggccgg
    10441 gctcctcctc gtcccacagg aggcgcagca gccggcagga gacgtccgag ttcgcggcga
    10501 agagctcctc gacggcgtcg tggacggccg ggccgccgta acggctgatc tccgggtggt
    10561 aggtggccac ttcgaggcgc tcggcgagac cgcgccggac cagcccctcg ccccaggcga
    10621 gcagcgcggg cagggccgcg gcgggcgccg ccgtacggac gcggatgcgc aggtgggcgt
    10681 cggggtcggc gtaccggatg tagaaccacc ggtccggatc ggcgcccgct tcccgcaact
    10741 ggggtagcag ggcggggagt tcggtcgctg cgatctcgtc gtggaggtcc cgggccgcgt
    10801 acagcttgag gtacgaccac gaggagccgg gcagatgggc ggggtgcgcc gagggcgcgg
    10861 ccttgcgccg gatctcctcg ggggcgaggc cagggccgct ctcccgggcg gcctcccggg
    10921 ccccggtggc gatcagcggg atgacgacct ccgagaggtg gccgcgcccc gacccgtccc
    10981 gcagccaagc ggagtccgga ccgggcagcg cctcgtggag ggtgacccgg ccggagccgg
    11041 agccggcccc gccgcccagc tcggcgagga gttcgtccac gcagagcgga tggtcgaggt
    11101 cgaggagcag ccggttgtcg tcgtccgcga ggtagacgta ccggggcacc ccccagtcgc
    11161 gccgccagcg ggccacctcg tccgccgaac gcggcaccgg caccggcccg cccgccgcgg
    11221 gggcggcctg cgcccccgcc gggtacaggt tccactcggc ggcgcgtacg acgacccggc
    11281 cgcgcacgac gcgcggcagg tgcggggcgc cctcgacggg gccccagccg aaaccggcgg
    11341 gggtggcgta ccgggcccgg gagacctcca gcaggaagcg gcagacgttg ggcgcgccgt
    11401 acgggctgag catgtggttc tggacgacga cgagttcgcg cccgagccgc gccgagtaga
    11461 ggcgcaggcc ctcgtcggcc gcgccgacgt ggatgtcggc gaggtcgatg acctgctccg
    11521 gggcggccgt cggcgcgacg ttgaccggga tctcgtacgc gtgcaccgcc ggccggatcg
    11581 ccacgttcgc gccgcgcccg ttggcgggca ggtacgccag ttcggcgacg acgacgtccg
    11641 gttccagggc ctcgcgggcg cgggcgtagg cgcgcagccg atcggtggcg tccgcgccga
    11701 gcaggtggcc gaaccggccg aaggtgcgac cgccctcgcc gaggccgtcg gggttgagga
    11761 cggcccgcca ctcgccccgg tcgatggcct cggggccgtc cgccgcgatc tggacgtacg
    11821 cgtcgaggcc cgggcagtcg gggcgcccgg aaaggcccgc tgagttcgcg gcgttcgcgg
    11881 cgttcgcggc gtccgggggc agcagccggc ggagcacctc gtcggtcagc tcgacctcgc
    11941 cggcgccgcg ccgccacgcg tcggccgcga gggcgacgag cgcccgggcg gtgtgcgggt
    12001 cgtcctcggc gacgggctgg ttcagggcca tggcgcgcgg cggggtcagg tagccgcccg
    12061 gcgcgtccag gccgcgttcg gcgccgagca ggtcgaggac ggggacgagc gcgtcggagc
    12121 cgtaccgctc catgaacgcc tggtggtacg cgccgaggtg gtcgtacccg gcgggcgcgg
    12181 cccggcccag ctcggccagg cagccgacgg cctcggctac ctcggcggcg atctgccggt
    12241 tcagggcggg cgcggcgagg tcgagggcgg agtccacctg cgacggctgg cccttgtgga
    12301 ggggtacgag ggcccgctgg gcggcgcgga gccggcggag ggcgtcggtg tcgccgtacg
    12361 gcgcgcggcc ggtcagcccg acgatctcgc ggagcgcggc caccgccggg tggtcgactc
    12421 cggcggcggt gagccggtcg aggacgtacg cctcggggcg cggctcggtg acgggcggcc
    12481 gcaggtcggt gacgagcagc cccagcccga ccagctcggc gacgaacgcg ctgatccgct
    12541 cccggccggc cgcggggaac tcctcggcca gctcggtgac cagagtggcg tacgggaccg
    12601 gcgcggcggg cggggcgagc gcgcggatcc gggcgagggg ggcggtgtgg cggacgcgta
    12661 cggcgcggcg gtcggaggcg tcgccgtgca ctccggagga gggcagcacg agccggtcgc
    12721 ccacccggtg ggccatggcg ttgacggaca ccccgagccg ggccagcgac tgcgggtcct
    12781 cctccaggcg ctgcaccagg gcgagcagcc aggccgtgtc ggcccgtacg tgggcctcgc
    12841 cgagcgcggt ggcgccgagg cgggcggtgg tggtgtcccc gaaggtgccg agggcgacgc
    12901 cggagaaggc gccgaagggg gtggggcggg tgctcatccg ggtgaggtag cgcagggcgc
    12961 gggagtgcac ccgccgcgcc tccttgccgg aaccggaacc ggaacccgaa ccggaacctg
    13021 agcccgaccc cggcgccgag ccgtcgagct tcgccagccc gtcgagcagc ccgctcccgg
    13081 cggcgacgag cccgtgccgg acccgggggt cgtcggcgag ggcgcgcagc agccgggccc
    13141 gggtgcgctc gcggtcggcc ccgtcgaggg cgtcccgcca gacgccgacg ggcagggccg
    13201 gcgcgcgcag gaggtggaag tcgagggcgt ggtaccgctg catggggcgg gtcggttcct
    13261 tgcgggtctc gggaagggaa gggtcggggc ggtaagggcg gtccggctca ccgggggaac
    13321 agcacgctcc accagccggg ccggtggccg gtggccaggg cgcgcagggt gagcgcgatg
    13381 ccggcggctc ccgtgagcag cccggggttg tcgacgacgt gcccggtggt ctcgtggtcg
    13441 cggtagagca gcggcagccc ggggtcggcg gcgtccacca gccgcagggt gaggcccggc
    13501 agggcccggg cggccccggc gctgccgtgc gcggcgaact cgtgggcgag cgcggcgatc
    13561 ccggcgagcc cgtggcacac ggtcggcgag cgcggtacgt ccccgtcggc gacccggtcg
    13621 agcagcccgt cgagcgcggc gaacgcccgc gcctccaggc ccggatcgcc ggtcgcgcgg
    13681 gcgacggcta gcagcccggc ggcgacgccc ccggtgccgt ggcaccaggc gggcgcggtc
    13741 tcgccgccgt cggccggcac gacccgcgac caccgcagcc cgcccgcacc gcccgccacg
    13801 cccgcgccgc tcccgccgcg tccgggtccc gtgccaccgt cgccgacggc cagcagccac
    13861 ccggtcagct cctccatggc ggcgcgctgc cccggcaccc gccggtcccg gcgccacgcg
    13921 gcggcgaggg cggccgcgat cccggcggcg ccgtgcgcca tgccggtgtc gagccggccg
    13981 cccacggccc agttcccgtc ggcggccacc cacacgaggt ggcgcaggca ccgctccagg
    14041 gcctcctcga cgagcggggt cgcgggcgcg gccgcacaga gctgtacggc gatcccggcg
    14101 gctccgtaca ccaggtcgta gtggtggtcg gcgacggcgc cgggcaccct cggccagtcg
    14161 gcgtcgatca cctgccgggc cagctgttcg tggagccgcc cgagactggg gaggaagcgc
    14221 ggctcgtcgc gggacacgtc ctggagggcg aaggcgagcc cggcggtccc gtcgaacaga
    14281 ccggggtggt gcagcgggct ctgcccggtg gcggcgaaag cggcccgagt gaaggcgcgg
    14341 gcgcggccct gcccctcctc ccgcccggcg gcgtgccggt gcaggagggc gaggccggcg
    14401 tgcccctcgc tgagggaggc accggcccag aaggacacgt cgctctggcg ggcggcgcgt
    14461 acggcggcgg cgtcggcgcg cgccggggtg tcgaggcgct cggcgatcag gccggccacg
    14521 gcctcggccc gggcggcgag cccggccgga aggggcggta cgacggtcat ggatggccta
    14581 gcgggcttcg gtacgtgcgg tacgtgcggt gcatggggcg ccggagcgga tcctcggagg
    14641 aggcccctcg ggggaggccc cccggccggg aaacggccgg ggaacccacc actcgacgcg
    14701 aacggcgttg gtgtggtcag cacttgccgt tcgtacggac ggcggcgcag gccgcggtca
    14761 tcttgatcgt ctgcttgatc gtctgcttca cgacggcctt gctgacgatg cgcgaggcga
    14821 tgctcgcggc gggggacagc tgggtctcgg ccgggtcggc ggaaacggtc acgcgggcgt
    14881 cgaggtggaa ctcgtccatc ggtactgcac ctttcatctc acacaagggg ccgccccccg
    14941 tgtcggaaca ccggaaggcg ttccggtggc ggcccggaaa tgaaattacc gacgggcgcg
    15001 agacggcagt acccgccgaa tttccttttc ccaccccgcc gttcggcggc cgtgggaccg
    15061 ccggtcagcg ggactggagg gcgtccagtc cgacggccat gcacagggcg aggacccggt
    15121 cgagcgaggg gtcctggacg cggatcacgt agcggtcccg gatgccccac ttccgctcga
    15181 cggacaggac gggcttgtcc tcccgcacga agtcgaagtg gtagacgaac ggcaccggcg
    15241 gtacggggat cacggggacg acgaggtcga gcagctccca cccgcgccgc gcgagggcga
    15301 ccccgagccg ccgttccttg ccgaccgcgg cggcctcgtc cccctgcgtc aggtgccagg
    15361 tggagcgtat gagggacgcc ttgacgtcct tgcggaacgt gccgatcgtc gccccgtcgg
    15421 gccggctgac gtcgtacgtg gccccgaagt cgatgacctg ccgggccttg aaccccccga
    15481 gccggcgggt ccggtcctcg ccgctccaga gggtcagttc ctccttcagc gcgagccgct
    15541 tctgctcggc gaacgcgagg acctgcccgc cgtccggcgt cgtgaccgtg tagcggttga
    15601 ccagcggggt gatcttctgg gtcatcagat attcgttcag gtgctccata cgggaaccct
    15661 aggcagcccg gggttccccc tccctacgcc tgagggcgga acgcaccccc gccgaccggc
    15721 gggtacaccc ccgccgaccg gcgcccggcc ccgccctatc cgtcaccccg gccggatccg
    15781 gcgtccagcc acagcggatg ctcccgcgcc gcccaggacc gcgcgaccga cccggtgcgc
    15841 atgccccggc gcgcctccgg atcggcgagc gcccgtccga tgtgcccggc cagcaccact
    15901 ccgatcgcca gggccagcca gtcgtgcacg aaggtggcgc tggtgcgcca caccagcggc
    15961 gccaggtgcg tgaaccacat cagcagcccg gtcgccagca tcaccaaggc ggcgcccgcg
    16021 atccacgacg cgtagagctt ctgcccggcg ttgaacttcc ccgcgggccg ggacgcgcgc
    16081 cggcgatcgc gtcgccgggc cgcgcgcagc cacgtccggt cgtgcggccc gaagcggttc
    16141 agcctgcgca gatcggcccg gaacgccggg gatccgagcc cgagcaggaa gggcgcgggc
    16201 aacaggatcc cggcccattc gtgcacggtc acgacgagct cccgacgccc gacgagttcg
    16261 gcgacctgcg gtacgtacag ggcggccgcg gtcgccacgc acagcagcac cagagcggcc
    16321 gtcgtacggt gcgtccagcg ctcggcccgg ctgaacctcc gtacccgcgc gcccggttca
    16381 gacggtgggg gcgtcgccgc ggccgttgga ccggccgacc caggcgtcga cgtcatagcc
    16441 gcgctcctcc cagtagccgg ggcgcacctc ggaggtgacg gtgatcccgg agatccattt
    16501 cgccgacttg tagaagtaca tcggagcgac gtagagccgg accgggccgc cgtgcgcgtg
    16561 gctgacgggc tcgtcccgca tccgcaggca gacgaggacg tcgtcgcgcc gggcctgcgg
    16621 gagggtgagg ctctcgctgt acgcgccgtc gaagcaggtg aagcggatcg cccgggcccc
    16681 gggacgcacc ccggcggcgt ccagcaggag cgacagcctc acgccggaga aggcggtcgc
    16741 gggcacgcgc cagccggtca cgcactgcac gtcccgtacg acacgggtct gcggcagcgc
    16801 gcgcagcgcg tcgaggccgt acgtcgcggg gcgctcgacg agcccgtcca cggtgagccg
    16861 gtagtcgccc tcgggccgcc gcggcacgga ggaggcgacg gagtagtagc ggaacccgcc
    16921 cccgttgggg agcagcccgg tgaggccggt ggggtccgtg tccgaggcgg ccccgagcag
    16981 ggcctccgtc ccgcgctgca cgtacggcgc ggcgacgagc cccccggcgc cgagcccgag
    17041 catgccgagc accacacggc gtccgacggg ggcgccctcg ctgtcgggat ggtctgtcgt
    17101 cacgccccga gtcgaacacc gcgcgccacg gatgaccagc gaaaccgccg tgacgtcaga
    17161 cttccgtcat cacctgccgt cggagaagtt gtgcacgccc caccagcccg aggagtcgtg
    17221 atggaggccc acgccgacct cggtgaagtc cggactgacc tgcgccttgt agtggccggg
    17281 gctgtggcgc cacatcgact ggaacttctc ggcggcttcc tgggcggtca tcgaggcgtc
    17341 gctgaaccag acgatgttct cgccggtcca ggtccgcgtg ccggtcttca ggtaggcgcg
    17401 ttcctcggag gaggagtggg agaacccgct cgtccgcatg tgctcggccc acttgcgggc
    17461 gaagtcgctg aggtcctgcc tgagcgcgag cgggggccgg ccgacggcgg cccgctcggc
    17521 gttgagcagc tgcagggaca gcgactgggc ggtccggacg tcctgcgtgg aggtacggtc
    17581 cccgggcacc ttggggtccg gccccgccgg cccgctcgcc ggcgacgcgg cggccttgga
    17641 agggcgcgcg tgcgcggagg ccgacgcgga ggccctcggg cgggttgccg ccggggtggc
    17701 agtgacggag gcaacggggc gaggactgct ggagacggtc ccggtgctgg tgggagccgg
    17761 caccgcacca ccccccacca cgggatccgg ccgaccggcg agcgcggagg gcgcggaggg
    17821 cgcggagggc gcccccgcta cagcgaccgc tgtccgctca ggcgccgcac cggacaggag
    17881 cgcgtaggca cccccgcccc cggcgagcag taccacggcg gccgccgccg cgagcaccgg
    17941 cgccttgcgc cgccgcttcc ggtgcccccg gcccacccgc ccgagccggt cctcacggtc
    18001 gtgatcctgc atcgcatctc ctcgaagccg acggcccacc tggcctgaca cagagggaga
    18061 ctcccgggcc ccgcggagat aacaccttcc tcgccaggac cggcgaacga cttggtgcgc
    18121 ggccccgacg gaaccgggta acgtctttgt catgttcttc cagacgccga tttacgagcg
    18181 tggggcgtga cgggcccccg ctgacgccct tcgacgtcgc cgcgcccgcc ccccacccat
    18241 gaatccgtag atcactccac agttaccggg agaacccatg accgacagca agaacatcaa
    18301 caaccccgtg ggccagggcg gcggccagcg caagaagctg tcccgcgccg aacgccagaa
    18361 caacggcccg caccgcaacc tcgaccgcaa gggcgccgcc gaccagaagg cggagctgat
    18421 acgcaaaatg cgcgagaaga ccgccgcacc cgagcagccc aacaccccca cccaaacctg
    18481 acccaccccc gccaccccca ggtcccggac cgcacccccg ctccgggccc ttccgcgtca
    18541 cgcgcacccc cgccccagcc gcccgactgc ggaagccgcc tccgacgccg ctccacgcac
    18601 gcaccgggac gcccggccgc catcaccact cccctacgcc cacaccacgc gagcgacgcc
    18661 ctgctccgcg cggccaacgc ggaagcggta ctgccccggg aacccgatac agccggacac
    18721 gggggacgat cgtcacggac ccggacggta cgcccgaaga acgggtcaag gagaggccgg
    18781 agcacatgcg taacgggaga cgcaagaaca aatgaccgcg atcgaacgcc tatggggaga
    18841 cttcgagctg cccatcaagg acgcactcca ctatgccaac gggcactcct acgatgtcgc
    18901 cctcgactcc gccgcaccga cgggtttcac ggtgctaacc cctttcgatc tcgctggaac
    18961 gctggaaggc gacccgtcgt gggtgtcctc ggtcgatggg cttgccgccg tagacctggg
    19021 agaaaagggg ctgctgtggg gcggcgaggg ttcgcacggg tcggaaggat tcatcgcacg
    19081 cctgaccgtt gaccgcgcgc taacttgggc gatgttcttc acggagtcga atccgttcga
    19141 ccggattcga ctgtcaggaa acgttgccac cttcagctcg acctcggggc tggagatcga
    19201 actcgacatc gacgatccac gaaccccaat tcccgagccc ggcccgaccg ccgcccggat
    19261 gaccgacacc gccgcagaca cctcctccta gagaacttct cccgtcctcg ccggtgggta
    19321 cgaggcgctg tcgtgccccc acggcccgat gccccccgag acaccggccg agctcctaca
    19381 gaaggaggtg gccgccgccc tcgtcaggga tggtgcgcga ggcccgagcg ggactgggta
    19441 acgaagaagg cccaggtcgt tgacctaggc cttcgttcaa gagcggacga cgggaatcga
    19501 agcgggtgag cgttgccacc gcgacacggg gccacgctct ctgcgtgatc gaggccaaag
    19561 gagttcacac ccgtcgacgc cgcacacgcc ctgacctgtg cagaccctga taaccccggc
    19621 gactggaccg gtgtcgagag gacgttccgg gacggacatg ccgaaacgtg gtgggcagcc
    19681 cctcggtcgg tggggccctg acggcaacgt ccgcctggtc gtggccacca ccgacccggc
    19741 caccctcccc gcacacagca cctggtacct ggccaccgac ctgccccggc ccggcggacc
    19801 ccgtgaggcc ggcaaaccac cgctagaggg gcggcgcccc gcgcagatga cgtacgagct
    19861 gttcgagggc ggtccagctc tcggcggtct cgccgtcgcc gagcgcgtag tagtagcccg
    19921 gccgggcgct ggggcccagc tgcaccgggc gttcccgcag cggcgtcctg ctcgcggtgt
    19981 cgcgccctgc ctcccggacc tccgcggggc ccagtacgaa ggcgtacggc agcggtgggt
    20041 gctcgaagcg gggcggggcg ctcaggtccc ggcgcgcctc gcgcagctgg cagatcatgg
    20101 tcttcagccc gtgccgggtc accagctcgc cggccagctc cggcagcgcc tccaggggca
    20161 gctgctcacc gaggccgtag cccaccgtga gggtgacgtc ctcctccacc ccctccgccg
    20221 tgcggatcac gcgcagggtg gcgacggcgg gccggtccgg ggtgccgacg accaccgtcc
    20281 aggtggactg gggggcgcgc tcgtacgcca ggtcggtcag ctgccgccgc gaccaggtca
    20341 gaccggccgg ctccgaagtc ccccagccgg ccggcgggct gccggtcagc gcccggtaag
    20401 cggcttccag cccaccgccg aggacgaggt ccgcctccgg cgggtgcagg gtacggaagg
    20461 agacgatgag ctgacgctcg ccggtgggcc ggacctcggt gaacgcgtcc gccaccgggg
    20521 tctcaccgct ctcgtcccgg tccgggcaga aggcgccgtc ctgccagcgc agcaccgcgc
    20581 cggtcagccc gtcgtagtag ccgcaccgct cgtcctgcac cacccagcgc gagggcaggg
    20641 actgcagcag catgcgggtg ggcagggaga gccggcagtg cggcggggtg acgatctgca
    20701 gggaccggtc gctctccacg gtggcccgca acgcctcgga gagccagctc gtcatgggaa
    20761 cgaccgggcg gtcctggagg acgacggcgg cctcgtcggt gagcatgtcg acggccggct
    20821 gggcagcggc gggtacgggt acggcagtga tgcccgcgac gtcgaccggg cgtgccgcac
    20881 cgatggtgcc gggggcgtcc ggcggccaga cccggccgcc cagaagcatg gtcagacggg
    20941 ccgcgaaggc acccgcaagc tgctctgcct gggggaggcc cgtggtggcg cgggcctcga
    21001 tccaccacgc cgggccgtcg ccggacggct cggcgccggg ccccagcagc cgggccgcct
    21061 cgcccggcac ctggagcatc agcggcgcct cgatcgagac gagcggccgg ccctcggcgt
    21121 cgcacagctg gatcacggcg ccctcgccgg tggtcccgat cgtcaggtct gggccgccgg
    21181 ccagcaggcc cgccaggatg ctcagggcgt ccggcatgcg ctcggtaagt gcgatcacgt
    21241 ccttggtcat acggtgttcc ccctggtcat acgtggtcgg ccggagtttc ggtgtcgccg
    21301 tccgcggcgg cgagcgctgt ctggaccagc cgggtcggct cgccccggcg tacgagcgtg
    21361 ccgcgcccgg gcggctggct gttcgcgtac acgccgggga acagctggcc ctcctgccgg
    21421 tcgccggtca tgacgaccgc cgtcgtaccg ctctcacgga gcgtcatcat gaacggctcg
    21481 tacagcgccc gcgaggctcc cgccaccctg cgggtgacga cgaagtgcag gcctatgtcc
    21541 tgcgcggagg ggatgaacgg cacgaacggc gcgagcggtt gctggccgcc gctggtgagg
    21601 acgtcgtagt cgtcgatgag gatgacgatg cgcggacccg agtaccaagt gccggacgcg
    21661 agggcgtcct gggcggcgag gtcctcgggc atgcgtttct cgagctcggt ggcgataccg
    21721 gtggccagcg cgccgcacag ccgtgagttg tgggcgtaac cgccgcggta ctcctcgggg
    21781 accagcctgc gcaggccccg gcgcgggtcc atgaccgcga agacgatctc ctcgtcggag
    21841 tagcggtcca tgagcccttg ggtgaccagg cgcagcaggt tggtcttccc gcactcgctg
    21901 tcgcccagga tgatcaggtg ctggtcgcgc ttgaacaggt cgagcaggac gggcgcgagg
    21961 gccgtctggt ccagtccgag cggcacccgg ttgggttcgg ccgtcacgga cggcagggcg
    22021 gcggcgggga tgcgggtggg cagcaccctg atccgctggg cgccgtcgcc ggaccaggac
    22081 gagcggatcg ccagggccgc ctgttcgacg gccgggccca gctcggaggt cgaggccagg
    22141 gagtcgatgc ggggcagcgc cgtctgggcg aagagcttgc cgtcggtcag gacgcggccc
    22201 ttctcgtccg gggccagggt ctcggcgagc ttgcggtcga tgctggagtc gccggggtcg
    22261 ttcaggcgca gctcgacgcg ggtgccgaac agggactggg tggcgatgcg gacgtcgttc
    22321 cagcgcagca tgcccgcgac gacgtggatg ccatagccgc caccgcgctt gagcaggtcg
    22381 gtgaccgcgt cctcgatctc gtcgaagtca tcgcgcaggg cgccgaagcc gtcgacgagg
    22441 agcacgatct cggtcgagga cagctcgggg agccggcctt cggcgcgcag ttcgcgcagc
    22501 cgctcgacgg agtcgatgcc gtgttcgcgg aacagctcct cgcggtcggc gagcatgccg
    22561 cggatctcct cgaccgtacg ggcggcgcgt tcgcggtcgg cgcggccggc gatgccgccg
    22621 acgtgcggga gcccggtcag ggcggcgagg ccgccgccga tgaggtcgag gccgtagatg
    22681 ccgacctcgc gcggcgtgtg cgtcatggcg agggacagtg ccagcgtgcg cagcagggtg
    22741 gtcttgccgg actgggggcc gccgatgacg gcggcgtggc cgccggcgac ggtgaggtcg
    22801 aggacccact gcccctgcca ctgcttggcc gggtcgtcga ggaggccgag cggcaccttg
    22861 agcgggcccg gccggacggc cagctggatg ccgcgctcgc cggcccggag cggacctgcg
    22921 gaggtgtcca gggcgatgac ccggggcagc ggcggcagcc agatggcacg ggtgggccgg
    22981 gccgcgtcgc ggagttggtc gacgacgacg gacatgacgg tcggcccggg gttgcggtgg
    23041 cgcatggccg gctggccctc gccggggccc gtctcgggct cgccgagggt gttgaactcc
    23101 gggtaggggt gtacggccgg gcccgcttcg gcgtcccggg cgaccgggcc gtggtagggg
    23161 ccggagacga agctggcctt gaaccgctcg tacgcgctgg tgtcgacctt gaggtagccg
    23221 aatccgggga tgggcggcag gtggaaggcg tcggtggtgt ccagcaccgt acgggactcg
    23281 tcggcggaga aggtgcgcag gccgagccgg tacgagaggt acgtgtccag gcccttgagc
    23341 ttgccgccct cgatgcgctg gctggagagc agcaggtgga cgccgatgga gcggccgatg
    23401 cggccgatgg acaggaacag gtcgatgaaa tcgggtttgg cggtgaggag ttcgccgaac
    23461 tcgtcgatga cgacgaagag gtgcggcagc gggtcgaggt cggggcgggt ctcgcgcagc
    23521 gcggcgtagt gcccgatgtc ggcgatgttg ccggcgtcct tgaggacctg ctggcggcgc
    23581 ttcacctcgc cggcgaggga ggagtggacg cgctcgacga gaccggcctg gttctcgagg
    23641 ttggtgatga cgccggcgac gtgcggcagg ccggcgaagg gggcgaaggt ggcaccgccc
    23701 ttgtagtcga cgaggaccat ggcgaggtcc tccggcgggt gcgaggcgac gagcgccagc
    23761 accagcgtgc gcagcagctc gctcttgccc gagccggtgg cgccgacgca caggccgtgc
    23821 gggcccatgc cgagttcgga ggattccttc aggtcgagca ggaccggctg gcgggagtcg
    23881 ctgatgccga tcggtacgcg caggaaggcg cgttcgctgc ggggccgcca cagttccttg
    23941 acgtccaggg cggccgggtc ctcgacgccg agcatctcgg cgaaggcgac ggggccggag
    24001 agcggggcgt cgacgaggga ctcgggggac agcctcagcg gggccagcag gcgggccagg
    24061 ccctcggcgc cgggggcggt ggcctggtcg gctgtgccgt cggcggtgac gggctcggag
    24121 gggcgcaggt catcgatgtg gacccggtcg ccgtcgacgg tgatgcgcag ggagacctgg
    24181 ccgggctcat gcacccgctc ggccaccagg tgcagcacgg tgacgcccat gtcccgcagg
    24241 ctcacggcct cgtcggggcg gggcagctcg cgcgcgtcgt caccgtactc gtcgctgacg
    24301 atcagcagcc ggtcggtcat ctccagcgcg tccttgccgg aaaggccgcg ccgcacctcg
    24361 gcggcgtagg aggcgcgggc gcgcaggtcc cggtgcatga gccgggcgag tggggccagc
    24421 gccggggcga tgcggcgggc gctgacgggc ccgtcgtgct cgtcggggtc gaggatgtgg
    24481 ggcagccact tgacccaggc ccagtcggtc atgcggtcgc cggggcaggc gagggcgagg
    24541 gcgacgtcgt cgggggcgtg ggcgaccgcg
//
