LOCUS       NZ_BMVE01000003        21125 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000003
VERSION     NZ_BMVE01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 698120)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 428548
            Orig. end                         :: 449673
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21125
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="6"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21125
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21125
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11125](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11125
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(454..468)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    485..499
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.59"
                     /tool="antismash"
     gene            complement(567..1244)
                     /locus_tag="IE248_RS12020"
                     /old_locus_tag="GCM10010336_24430"
     CDS             complement(567..1244)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020387.5"
                     /locus_tag="IE248_RS12020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24430"
                     /product="RES family NAD+ phosphorylase"
                     /protein_id="WP_190030698.1"
                     /transl_table=11
                     /translation="MARPAKLPGKLAGTPHQVVWPAGTTLYRVHRKSRSAADFNATVVD
                     HHFGGTRFDSTPNDEYSYLYLAPSAETALVESLLKELPVDDGEPRVVSYSAIEDRRLSR
                     LELLTDVTLLSLLDRRATSAVNQGTWLTQSESPDYPFTRRWGHWLRGQADWAQGLVWTS
                     RQNHPEPTAVLFGDRFGPLVREDGNEVLRPVPGGIDLDDSAGRRWLDSALDPYCARVGA
                     PAD"
     gene            complement(1246..1887)
                     /locus_tag="IE248_RS12025"
                     /old_locus_tag="GCM10010336_24440"
     CDS             complement(1246..1887)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS12025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_24440"
                     /product="DUF3168 domain-containing protein"
                     /protein_id="WP_143196368.1"
                     /transl_table=11
                     /translation="MTEADRIQLDRLLGLFANVSDDDGLRAVGEAVAAHVRGRLPADDP
                     ALRRWRSTMAPDRSAAPGLIRRMATRHGHHVPVRSSGARPLHHRAEPAGPAAPSSWDRI
                     RERLLSASSLSEAQVRDVLRQDPRHPHLIRLTRKGGEVRLPSFQFQEDCVPVPLVLAIN
                     EVLRASKDPWGAADWWLGPNHWLAAPPAEVLGSVPDDELMAAARAVGEGD"
     misc_feature    1881..1894
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(1888..1904)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.74"
                     /tool="antismash"
     misc_feature    1939..1953
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    2052..2064
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     gene            2295..7661
                     /locus_tag="IE248_RS12030"
                     /old_locus_tag="GCM10010336_24450"
     CDS             2295..7661
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024180.5"
                     /locus_tag="IE248_RS12030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24450"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_190030699.1"
                     /transl_table=11
                     /translation="MDASGSDDIRALEREIAALRERARVLHPGGQERWNTEADLAELLF
                     VHALEVVSAGAATAAGAPPLPEGLAEARALLDRLLSQRRPGSASYHWACLLAARAARGE
                     AELTGDPDARDAAIERFETAIAPLPPYGPDTFPPLPGEPEWWTPALAVDARCELGLALY
                     NRSRELTGGSRSRDLDRIVSLLTPVVDGPEAGLAQDLQVTLACLGLALADRSRAPGHRG
                     PDRPADRTEAIGRLRAARETPSEDEVPGAVPFQLALLLFCEHDDGCGGSEGADGRGPYA
                     RPTGELDEALALLWPLTLDPSADGGEATELATMTARHLYEHDGGPAAETALIEWHRRAI
                     DHPGTQRRQVRANRTDLALLLIDRAERGATAPAPGTPAPGTPAPGTPSRSDDLGEAARH
                     LELALDDLALKERAPSVRLRAEDEPPETDADRAEERLNMLLGLVTLLSMLLPESSDDAR
                     LDRLIRRGQELIEVIPDADTERGGACLRLALALFERTSRRTLPQLPALLMRAMTPDRAD
                     PGISLVANVPGVREDNELAIALLRTGVGLYGYEDELYEAAAIALAVSLLIGYTVRLPER
                     DTALIRDAVRWFRIVLDRVPEGGELHSPDLEDLFIGALLNSVWTSEPFVRAQTGSWRDG
                     EGIPDVSRNQSVEDDLQSLRHLLETAVRCREQPVPVYEMVLLLITFMRGKGELDDAEAR
                     HWRDRLRRASAYTDPAEESLKGFLLLAAGAFGYELARRGAAGPAELAEADRLLREGARH
                     MPPGSDFAEWAEGLRATGPATLIQQLLGVFMGGASAPGAAAAGAPGAARRPADDAVRAP
                     GPARPPGSARPPGPVRPPARSAPAEAEDIPLSAAAVLPGDGSPYPFTEPVGRVLEIVAG
                     PAEQRSAPVMAAHALALHRRWLHESEIADLTDAVTLTRRAIAAAEGADGPLADRLSLLL
                     AGMLRDRYLLIGDRMDLQAARSAYERLRDRSDPRAPHPELATLLARPGAAGQPDLAALL
                     RPARPAAPGAFSAELLAAAALTGLLAAREDGVADRAAVELAEAAEALPADHPLLPAVLS
                     ESGLFRATRAARADELAALREAVEDVVRAAALCPPGSAHRAPLLLRAAAVLCAHSDALD
                     AADPAGPAAPGSRTSSLDRGIDLLSGAVDEAGPSFHGARARCRYGLGSLLLTRFRRTRD
                     RADLDRAVGLLRDARTAVLSRPGDPFTVLLTRALAEALRAHGPEDPDHRAQSREAAKSV
                     LAAHGRAVLLQTGTETALDSARAAGSDMMRLVEWCLTDGRTEEALEALELGRGLVLNAA
                     TVAASVPELLEREGRPELAQAWRRADPGRVPGTPADGPVVIPDGLRLLVLQALEGGPAE
                     RRILSAPTPAEIGRALRTVGHDALVHLIPGRDGSGDALIVTATGAVERLRLPGLCVTDD
                     GPAAAYGEALQEFAAATREPVVLPGEDDPAVMWELYRRGRKRLGRASDRWRGALEPLCS
                     WAGEVAMAAVIEHVGAGRRHRPARLVLSPVGMLGMVPWHAARLPGAPGVSGEPGGGYAC
                     GRAVISYCSTSRQLVEVAARARLPWNGAQAVVADPGGTPAMHEEARLIAALYPGATVVG
                     PIDDVPEPGGPGSRPPSRPATAAAVAPLLPGRGGSSVAVCHVNCHATARATPSASSLDL
                     HPAAPVPQVLTLAEIQALAHGRDPSAPGGLLVLANCTSDLTLADYDEALTLSTAFLTAG
                     AASVVGSLWAIADDIRTSMVMYVFHHYLTGRGLPGHPEAVGSPADALRAAQLWMLDPHR
                     IVPPALSAVLEERPGLDLDAPHIWAAFTHHGH"
     misc_feature    7678..7687
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.37"
                     /tool="antismash"
     misc_feature    7684..7698
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    7692..7706
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            7797..8282
                     /locus_tag="IE248_RS12035"
                     /old_locus_tag="GCM10010336_24460"
     CDS             7797..8282
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS12035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_24460"
                     /product="hypothetical protein"
                     /protein_id="WP_053065838.1"
                     /transl_table=11
                     /translation="MVAALKFAHSNLDGLKVKELVDKKGIEWYINHCAALAATTGVASG
                     MGGPATMVLGVPADMANTIAQQFRVTMAVIYHKTGSYSLSFDEFMKIVAVSLGVEVGTQ
                     VVVRVAAEIFKRLTAKIAGKFIPLLGGVIGGGLNYGFIKAQGKAMLALDFDKLSRSA"
     misc_feature    8265..8267
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8265..9413)
                     /locus_tag="IE248_RS12040"
                     /old_locus_tag="GCM10010336_24470"
     CDS             complement(8265..9413)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827487.1"
                     /locus_tag="IE248_RS12040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24470"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_190030828.1"
                     /transl_table=11
                     /translation="MNEALLRSLTPSVLGILVRRGADFAAAEDALQEALVEAVRVWPAD
                     MPREPKGWLITVAWRRYLDAARSDTARRRREDLVEEEPAPGPAPGVDDTLQLYFLCAHP
                     ALTPSSAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRAKRTVSGVRFDQPGDVATV
                     LRVLYLVFNEGYSGDVDLAAEAIRLTRQLAASIDHPEVAGLLALMLLHHARRSARTGPD
                     GSLVPLAEQDRGRWDTVMIAEGVAILQAALARDRLGEFQAQAAIAALHADAPTAGETDW
                     VQIVEWYDELVRLTDSPVVRLNRAVAVGEADGPRAGLAALAALDDALPRHTAVAAYLHE
                     RDGDLETAARLYAEAARKASNLAERDHLTRRAARLTQLRRTG"
     gene            complement(9422..9829)
                     /locus_tag="IE248_RS12045"
                     /old_locus_tag="GCM10010336_24480"
     CDS             complement(9422..9829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007512669.1"
                     /locus_tag="IE248_RS12045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24480"
                     /product="YciI family protein"
                     /protein_id="WP_037798881.1"
                     /transl_table=11
                     /translation="MAKYLLLKHYRGAPAAVNDVPMDQWTPEEISAHMRYMQDFADRLE
                     GTGEFVDGQALAPTGTFVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVDSYERAVELAG
                     ELSAAPGAGGKPIHEWLELRPFLTAPPTITE"
     misc_feature    9804..9820
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(9988..10003)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.28"
                     /tool="antismash"
     gene            10001..11125
                     /locus_tag="IE248_RS12050"
                     /old_locus_tag="GCM10010336_24490"
     CDS             10001..11125
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959586.1"
                     /locus_tag="IE248_RS12050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24490"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_190030700.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8e-32, bitscore:
                     105.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHATVNAATLERVLGHRTRFDARFGQYFDSLAGRFDLPVPSRYVP
                     RCLDLLRDLSMRGGKRLRVVLLYEAARLVTTEEVPGLAEAALSIELLQTHGLVHDDIID
                     DAPLRRGGPSTYYAYRREFPGHGATALGLAVLAGDLAGFLSTQVLLEAEAPVALRQALL
                     GVHTRTAAETVAGQIADLERDAHALPDEEFLHTVTDFKSARYSILAPLTMGLLAAGEDP
                     APHRARLHRYARLVGISEQMRDDCLDLFGPFGEGAGSDAVAGAAPAVADKSTGADIRSG
                     RRTYAVRAVLAAATGADAALVEAALGDPRCPDATLERIREIARAAGVDGRLKAEIRRHA
                     EEAAAEAASWEPYWRAEAVEFFRGLPMWNVDRMP"
     gene            complement(11132..11857)
                     /locus_tag="IE248_RS12055"
                     /old_locus_tag="GCM10010336_24500"
     CDS             complement(11132..11857)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321519.1"
                     /locus_tag="IE248_RS12055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24500"
                     /product="DUF4386 domain-containing protein"
                     /protein_id="WP_190030701.1"
                     /transl_table=11
                     /translation="MSETRRLAVVAGALFLVTEVAAIGGLALYRPVLEGPGYVVGSGAD
                     TRVFLGALCELVLALAVIGTGAALYPVLRRRGEAAAVGYVCGRLLEAAVIVVGIVSVLA
                     VVTLRRSAGPSGAADAASLVTAGKALVALHDWTFLLGPNFVLGANTLVLACLMYTSRLV
                     PRALAVLGLAGGALICASATAVLFGAYEQVSVAGSLAALPVFAWEVTLAVRLLFKGFDE
                     AAGDGAGEGARARVDALAG"
     gene            12002..12748
                     /locus_tag="IE248_RS12060"
                     /old_locus_tag="GCM10010336_24510"
     CDS             12002..12748
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981926.1"
                     /locus_tag="IE248_RS12060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24510"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_100580849.1"
                     /transl_table=11
                     /translation="MPADVPAEESRRTPLSRDRVLRAAVAFADGAGIEALSMRRLAQEL
                     GVVPMALYKHVANKEELLDGMVEAVVAGLDPHVPGADWKSAVRRRILGARDALVRHAWA
                     AQVIRSRTSPTPAVLAYLDSVIGMFRAGGFSLDLTHHAMHALGSRVLGLTEELFDAPPS
                     PGPRATATAPVSAPAADPAQTAAREAMALRYPHVTELAGAVAHDRSSVVGGRGCDDRFE
                     FEFALDLLLDGFERLHGQGWTSAPRP"
     gene            12781..13401
                     /locus_tag="IE248_RS12065"
                     /old_locus_tag="GCM10010336_24520"
     CDS             12781..13401
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612216.1"
                     /locus_tag="IE248_RS12065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24520"
                     /product="nucleoside/nucleotide kinase family protein"
                     /protein_id="WP_073798685.1"
                     /transl_table=11
                     /translation="MEFAELEERARTLAASGGRRILGIAGPPGAGKSTLAARLARALGA
                     ELAVAVPMDGFHLAQAELVRLGRADRKGAPDTFDAAGYAALLRRLRAAPGEGAGAVYAP
                     AFDRALEEPVAGSIRVGPAVSLVITEGNYLLYGAGEWAQVRPLLDEAWFLAPDDAVRVR
                     RLVDRHVRHGRDRAAAEEWVSRSDESNARLVAPGRAGADLVLE"
     gene            13421..14683
                     /locus_tag="IE248_RS12070"
                     /old_locus_tag="GCM10010336_24530"
     CDS             13421..14683
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.5"
                     /locus_tag="IE248_RS12070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24530"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_190030702.1"
                     /sec_met_domain="Pkinase (E-value: 2.2e-46, bitscore:
                     153.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAESGALIGGRYRLVELRGRGGMGRVWRGLDERLDREVAVKEIV
                     FPDGVDEERREALLHRFVREARAAARLNDPGIITVHDVVEHEGAPVIVMEYVTGPSLAA
                     QVARGGGMPVRRVAELGVLMVKALRRAHAAGIVHRDLKPDNVLLMDDRVIITDFGIAHV
                     ADATMTLTRTGTLLGTPAYMAPEQLEGGPPTPATDLWSLGATLYCALEGRPPFVAETFS
                     ALCVAIVMQDPPVPGRAGPLAPVLAALLTKDPAGRATAEQALAALEAVAGGAAQREPQP
                     QPQPQPEQRRRQRLPGSSLRGAGCFALVWLGTLLPWNHIREWHGFQRELLVGATAAVVA
                     LANAGLRPRGPAGPGWARFAGLNLALFLVAALIWPVWGLPAVIANGLLVGTVSWSLWWS
                     LSRAGVPAGVRPDAVSERGTR"
     gene            complement(14661..15521)
                     /locus_tag="IE248_RS12075"
                     /old_locus_tag="GCM10010336_24540"
     CDS             complement(14661..15521)
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-272). E-value:
                     2.8e-26. Score: 84.6. Matches aSDomain:
                     nrpspksdomains_IE248_RS12075_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558022.1"
                     /locus_tag="IE248_RS12075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24540"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_229895266.1"
                     /sec_met_domain="PF00561 (E-value: 2.2e-22, bitscore: 75.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-19, bitscore:
                     67.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLHFFTSYDGTELAYRVTGDGGAPPLVCLPGGPGRAAAYLGDLG
                     GLGAHRTLILPDTRGSGASAMPADLATCRVDRLVADVEALRGHLGLETFDLLGHSAGGS
                     LAQLYAAAHPGRLRRLVLVTPSFASIGLPSDTGAEEVLRSRAAEPWYARALPAYRAVKA
                     ARSFEEAAAHRPAFEPLMYGRWDAAARAHAAADPAQRSLPVSEAFYAGYAPDTEALAAR
                     LARLAAPVLLLAGERDLWPTAAAAARAAGVFPEAELTVLPGAGHYPWLDDAAAFAAAVT
                     GFLAR"
     aSDomain        complement(14706..15449)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS12075_Abhydrolase_1.1"
                     /evalue="2.80E-26"
                     /label="IE248_RS12075_Abhydrolase_1.1"
                     /locus_tag="IE248_RS12075"
                     /protein_end="272"
                     /protein_start="24"
                     /score="84.6"
                     /tool="antismash"
                     /translation="PPLVCLPGGPGRAAAYLGDLGGLGAHRTLILPDTRGSGASAMPAD
                     LATCRVDRLVADVEALRGHLGLETFDLLGHSAGGSLAQLYAAAHPGRLRRLVLVTPSFA
                     SIGLPSDTGAEEVLRSRAAEPWYARALPAYRAVKAARSFEEAAAHRPAFEPLMYGRWDA
                     AARAHAAADPAQRSLPVSEAFYAGYAPDTEALAARLARLAAPVLLLAGERDLWPTAAAA
                     ARAAGVFPEAELTVLPGAGHYPWLDD"
     CDS_motif       complement(15192..15239)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS12075_0001"
                     /evalue="1.80E-04"
                     /label="NRPS-te1"
                     /locus_tag="IE248_RS12075"
                     /protein_end="110"
                     /protein_start="94"
                     /score="14.1"
                     /tool="antismash"
                     /translation="DLLGHSAGGSLAQLYA"
     gene            15617..16579
                     /locus_tag="IE248_RS12080"
                     /old_locus_tag="GCM10010336_24550"
     CDS             15617..16579
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024248.5"
                     /locus_tag="IE248_RS12080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24550"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_199848616.1"
                     /transl_table=11
                     /translation="MSVEIRLTAAEVARVRFAVSPLAETVLGVRAALTATGQAVHHRWL
                     AEARDVLRDDPELPLLRNLLGHCLPSFLLPVPRERLPSLDEELADLCATDPAYFAAECA
                     AGAGARAAGRLPAAEVALPRLAGALRRCHDRLVAPHWGRMRAVLDADVGRRAVALVDGG
                     VEGLFTQLHRDIAWREGELVVGGRRRAGAAPCAVEASGHGLVLLPSVFAWPDVLVDRSP
                     VTAASIRYPALGVGLLWEPDRPTRDGVAAVLGATRAALLAALAEPLTTPALAARLGVTP
                     SAVSQHLGALRGAGLVSTRRSGRTALHLRTARAVDLLTG"
     gene            16725..17405
                     /locus_tag="IE248_RS12085"
                     /old_locus_tag="GCM10010336_24560"
     CDS             16725..17405
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.5"
                     /locus_tag="IE248_RS12085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24560"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_190030703.1"
                     /transl_table=11
                     /translation="MARPAPTPARSRRRRRIAVAGAALCAGLFVLLAVLVTARHGAPYP
                     LDSAAHRWSVRHRPAVAVAFARAVTSTGSGLFPYVCAAAAGVIAGRGTRERLWGAAAAL
                     LFLGFAQAVRFGVLHLIGRPRPPLADWATVAHDHSFPSGHTTASALAAGLLAWALVRRA
                     GPAAAAIPCVILAGWAVAVGLTRIYLGVHWPTDVLAGWLYALTWFAVGYAVFPYVLRMF
                     TDTD"
     gene            17432..18220
                     /locus_tag="IE248_RS12090"
                     /old_locus_tag="GCM10010336_24570"
     CDS             17432..18220
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037678.1"
                     /locus_tag="IE248_RS12090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24570"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_190030704.1"
                     /transl_table=11
                     /translation="MWAAGEAYEPYVGRWSRLVAAEFVRRLAAAPGGSWRDIGCGTGAV
                     ARAVLTAAAPRRVIGVDPAESYVRHARRHLAGPRADFVVGDALALPFPDGRATAAVSGL
                     VLNFVPDPARAAAEMVRVVGPGGTVAVYLWDYGEGGMRAIRAFWDAARTLDRRAEALDE
                     AVRFPLAGRKPLRELLTGAGLAGVETGEITVPTRFRDFDDYWGPFLGGQGPAPAYVASL
                     PEDHRAELRERLRATLPRACDGSIRLTARAWTAWGARPPG"
     gene            complement(18305..18520)
                     /locus_tag="IE248_RS12095"
                     /old_locus_tag="GCM10010336_24580"
     CDS             complement(18305..18520)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS12095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_24580"
                     /product="hypothetical protein"
                     /protein_id="WP_073777114.1"
                     /transl_table=11
                     /translation="MYEMRAESIADRCQLLWHVIAKDTTFSTLCGSLLNPDQTPPPAAD
                     PAAERYCAPCMTAFSRAVHAFGTPSE"
     gene            18671..18964
                     /locus_tag="IE248_RS12100"
                     /old_locus_tag="GCM10010336_24590"
     CDS             18671..18964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491103.1"
                     /locus_tag="IE248_RS12100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24590"
                     /product="hypothetical protein"
                     /protein_id="WP_037798895.1"
                     /transl_table=11
                     /translation="MAWASWTTTGVFPGAGGVRTEEVGIISGDLTVHTTWTGAQAQVAV
                     QYSSSSDWFTLSGSPVECVSEPESRDLHQAVVEAVRGGGGSGVPPHWATFAA"
     gene            complement(19241..20038)
                     /locus_tag="IE248_RS12105"
                     /old_locus_tag="GCM10010336_24610"
     CDS             complement(19241..20038)
                     /EC_number="1.1.1.30"
                     /GO_function="GO:0003858 - 3-hydroxybutyrate dehydrogenase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979647.1"
                     /locus_tag="IE248_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24610"
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="WP_190030705.1"
                     /transl_table=11
                     /translation="MTSKLPPALPLPAPGPAGVDLRGRVALVTGGGSGIGRACAVALAA
                     AGAAVHVVDVDAPSAASVARLVRGRAHVADLADPAAIEELPAQVDILVNSAGLQHVAPI
                     TQFPVERFALIQQVMVTAPFLLLRRVLPHMYASGWGRVVNISSVHGLRASAYKSAYVAA
                     KHGLEGLSKVTALEGAPYGVTSNCVSPGYVRTPLVEGQIADQAAAHGIGAADVVADVLL
                     TRSAIKRLIEPEEVAAAALWLCGPHTGYITGISLPLDGGWAAN"
     gene            20233..20730
                     /locus_tag="IE248_RS12110"
                     /old_locus_tag="GCM10010336_24620"
     CDS             20233..20730
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS12110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_24620"
                     /product="hypothetical protein"
                     /protein_id="WP_073798694.1"
                     /transl_table=11
                     /translation="MTPDIDTAELVAAVNTVERARNLLGEARDELGGAGVSRDQEWTAA
                     GSPVQTLQGADDMHRGSGQFLDDLALALGYAAAGLAEQALRQRERAGQGFLGLSGADRM
                     ARPLPAPTVEALELLRGLDLLTPEFRERITGALEAEAATYPDPAPQRPLRLGTSGLTPT
                     AG"
     gene            complement(20740..20988)
                     /locus_tag="IE248_RS12115"
                     /old_locus_tag="GCM10010336_24630"
     CDS             complement(20740..20988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158037.1"
                     /locus_tag="IE248_RS12115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_24630"
                     /product="DUF6296 family protein"
                     /protein_id="WP_073798695.1"
                     /transl_table=11
                     /translation="MSEDHEDRYELVFGSGEPEGEGEDLVVVSRTAQKGPGGHPVYADS
                     TGIVRAEISDQGEVRMLPSGGQQSLAQPTRARRPGSP"
ORIGIN
        1 cgaccctgaa cccctcggcg aagtcggtgc cgccctgcgg gctgagcgtg ggcatccgcg
       61 cgtgggccat gtcgctgagc ggcaggacac aggcggcagt gtcggagaac gtgaccaccg
      121 agacgcgggc gatctctccg gtggtcgggt cgtccaggat cgcccgctgc atggcgggga
      181 gcgcggtgtt catcgccgcc atcgggccgc ccgacatcga cccggacacg tcgatgagaa
      241 ggcagacggg gaataccgcg ggacgttccg attgcgagaa ctgggacacg ggaactccaa
      301 tttcgtgcgg acgcgcgaga cgggcatgga agtgaccgga agggaaaggg aggggaatgc
      361 cgggtaatcg gcatgaggaa tggagcggct cgcggaacat tccgcgcctc gcggctccgc
      421 attccccctg atcgcgtccc tccactatgc acgatcgggg agggtgatcg agcgctgttt
      481 tccgtatagt gaggcaattc ccggaggacg cccggactac gcccggatcg cgcccggccc
      541 gcgcccgggc cgggcgcccg gcggcttcag tccgcgggcg cgccgacccg cgcgcagtac
      601 gggtccaacg cgctgtcgag ccagcgccgg cccgcactgt cgtcgaggtc gatgccgccc
      661 gggacggggc gcaggacctc gttcccgtcc tcgcggacca gcgggccgaa gcggtcgccg
      721 aagagcaccg cggtgggctc cggatggttc tgccgggagg tccagaccag cccctgcgcc
      781 cagtcggcct gcccgcgcag ccagtggccc cagcgccggg tgaaggggta gtcgggggat
      841 tcggactggg tcagccaggt gccctggttg accgcgctcg tcgcgcggcg gtcgagcagc
      901 gagagcagcg tgacgtcggt cagcagctcc agccgggaca ggcgccggtc ctcgatggcg
      961 ctgtacgaga ccacgcgcgg ctccccgtcg tcgaccggga gctccttcag caggctctcg
     1021 acgagggcgg tctcggcgct gggggccagg tagaggtagg agtactcgtc gttgggggtg
     1081 ctgtcgaagc gggtgccgcc gaagtggtgg tcgaccacgg tcgcgttgaa gtcggccgcc
     1141 gatcggctct tgcggtgcac ccggtagagc gtcgttccgg cgggccagac cacctggtgc
     1201 ggtgtgcccg cgagcttgcc ggggagtttc gccggacgtg ccacgtcagt ccccctcgcc
     1261 cacggcccgg gccgcggcca tcagttcgtc gtccgggacg ctgcccagga cctccgccgg
     1321 cggggccgcg agccagtggt tgggccccag ccaccagtcc gcggcgcccc acgggtcctt
     1381 ggaggccctg agcacctcgt tgatggccag gaccagcggc accgggacgc agtcctcctg
     1441 gaactggaac gacggcagcc gcacctctcc gcccttccgg gtcagccgga tcaggtgcgg
     1501 gtgccgggga tcctgccgca gcacgtccct gacctgagcc tcggagagcg aggaggcgga
     1561 gagcagccgc tcgcggatgc ggtcccacga ggagggcgcc gcagggcccg ccggctcggc
     1621 ccggtggtgc agaggccggg cgcccgagga ccggacgggc acgtggtggc cgtgccgcgt
     1681 ggccatccgg cggatgagcc cgggcgccgc cgaccggtcg ggcgccatgg tcgagcgcca
     1741 cctgcgcagg gcggggtcgt cggccgggag ccggccgcgc acatgggccg ccaccgcctc
     1801 gccgacggcc ctgagcccgt cgtcgtccga gacgttcgcg aacagtccca gcaaacgatc
     1861 gagctgaata cgatcagctt cggtcaaacg ttcgcgtata tcgtcaggat tcgattcgag
     1921 gtcggccaga atcgaaagat caatatcgtc catgcatcgt tccccctcac gcgcctgcca
     1981 gtacgttccg ggacggcaaa gcggtcgcca cgagcgtact ggaaaaaccg gatcggtcca
     2041 ccgagtgcgc catccatatt gccaggcacg tacctcgccg ggcagaatcg cagcgtcccc
     2101 gccacgccat cgtgaaggca aggggcaaag aaggggatac ggggaccgcg acggtccccg
     2161 gggggagtcg gggatcgcgg caccgtgaac ttccggtgcc gcgggaaaac aggctgacgg
     2221 cggaccggca tccgctccgg atcgtgaatt ccggccgccg gaccgggccg tcgcggaaga
     2281 gcaacggggg gatcatggac gcgtcaggga gcgacgacat ccgggcgctg gagcgggaga
     2341 tcgccgcgct gcgcgagcgg gcccgggtcc tgcaccccgg tggtcaggag cgctggaaca
     2401 ccgaagccga cctcgccgaa ctcctcttcg tccacgccct ggaggtcgtc tcggccgggg
     2461 cggccaccgc cgccggggcg cccccgctcc cggagggtct cgccgaggcc cgcgccctgc
     2521 tcgaccggct gctgtcccag cgccgccccg gcagcgcctc gtaccactgg gcctgcctgc
     2581 tcgcggcccg cgccgcccgg ggcgaggccg agctgaccgg cgatccggac gcccgggacg
     2641 cggcgatcga gcggttcgag accgcgatcg cgccgctgcc cccgtacggg cccgacacct
     2701 tcccgccgct gccgggcgaa cccgagtggt ggacgcccgc cctggccgtg gacgcccggt
     2761 gcgagctggg cctcgccctg tacaaccgca gccgcgagct caccggcggg agccggtccc
     2821 gggacctgga ccgcatcgtc agccttctca cccccgtggt ggacggcccc gaggccgggc
     2881 tcgcccagga cctccaggtg acactggcct gtctgggact cgccctcgcc gaccgctcgc
     2941 gcgcccccgg ccaccgcggc ccggaccggc cggccgaccg taccgaggcg atcggcaggc
     3001 tccgcgccgc ccgcgagacc ccctcggagg acgaggtgcc gggagccgtc ccgttccagc
     3061 tggcgctgct cctcttctgc gagcacgacg acggctgcgg cggttccgag ggcgccgacg
     3121 gccgcggacc gtacgcccgg cctaccgggg aactcgacga agcgctcgcc ctgctgtggc
     3181 cgctgaccct ggatccgtcg gccgacggcg gcgaggcgac ggaactcgcg acgatgaccg
     3241 cccggcacct gtacgaacac gacggcggtc cggccgccga gacggccctg atcgaatggc
     3301 accgcagggc gatcgaccac cccggcaccc agcgccgcca agtacgcgcc aaccggaccg
     3361 acttggcgct gctgctcatc gaccgggccg agcgcggcgc cacggcgccc gcccccggga
     3421 cgcccgcccc cgggacgccc gcccccggga cgcccagccg ctcggacgac ctcggcgaag
     3481 ccgcccggca cctcgaactc gccctcgacg accttgcctt gaaggagcgg gccccgtccg
     3541 tacggctgcg ggcggaggac gagccgcccg agaccgacgc ggaccgagcc gaggagcggc
     3601 tcaacatgct cctcgggctc gtcacgctgc tgagcatgct cctgcccgag agctccgacg
     3661 acgcccggct cgaccgcctg atccgccgcg ggcaggagct gatcgaggtc attcccgacg
     3721 ccgacaccga gcgcggcggc gcctgcctcc ggctcgccct cgccctcttc gagcggacct
     3781 cccggcgcac cctgccgcag ctgcccgccc tgctgatgcg cgcgatgacc ccggaccggg
     3841 ccgacccggg gatctccctc gtcgccaacg tcccgggggt gcgggaggac aacgagctgg
     3901 cgatcgccct gctgcggacc ggagtcggcc tctacggata cgaggacgag ctctacgagg
     3961 ccgccgccat cgcgctggcg gtgagcctgc tcatcggcta cacggtccgg ctgcccgagc
     4021 gggacaccgc gctgatccgt gatgcggtgc gctggttccg catcgtcctc gaccgggtgc
     4081 ccgagggcgg cgagctccac agcccggacc tggaggacct gttcatcggg gcgctgctca
     4141 acagcgtctg gaccagcgag ccgttcgtac gggcgcagac cggctcgtgg cgcgacggag
     4201 aggggatccc cgacgtctcc cgcaaccaga gcgtcgagga cgacctccag agcctcaggc
     4261 acctgctgga gacggccgtg cgctgccgcg aacagcccgt gcccgtctac gagatggtgc
     4321 tcctgctgat caccttcatg cgcggcaagg gcgagctcga cgacgcggag gctcggcact
     4381 ggcgcgaccg gctccggcgg gcatcggcct acaccgaccc ggccgaggaa tcactgaagg
     4441 gcttcctgct gctggcggcc ggggcgttcg ggtacgagct ggcgcggcgc ggagccgccg
     4501 gcccggccga actcgccgag gccgacaggc tgttgcgcga gggcgcgcgc cacatgccgc
     4561 cgggcagcga cttcgcggag tgggccgagg ggctgcgggc gaccgggccc gccacgctga
     4621 tccagcagct gctgggcgtg ttcatgggcg gcgcctcggc ccccggggcg gcagcggcgg
     4681 gagcccccgg cgcggcccgt cgcccggcgg acgatgccgt acgcgctccc ggccccgcgc
     4741 gaccgccggg ctccgcccgc ccgccgggtc ccgtccggcc cccggcccgg tcggcgcccg
     4801 ccgaggcgga ggacatcccg ctgtcggccg cggcggtcct gcccggagac ggcagcccgt
     4861 accccttcac cgaacccgtg ggccgcgtcc tcgaaatcgt cgccgggccg gccgagcagc
     4921 ggtccgcccc cgtcatggcc gcgcacgccc tggcgctgca ccggcggtgg ctgcacgaga
     4981 gcgagatcgc cgacctcacc gacgccgtca ccctcacccg gcgggcgatc gccgccgcgg
     5041 agggcgccga cggccccctg gccgaccggc tgtcgctgct gctcgcgggc atgctgcgcg
     5101 accggtacct gctgatcggc gaccggatgg acctccaggc cgcccggtcg gcgtacgagc
     5161 ggctgcgcga ccggtccgac ccgcgcgccc cgcaccccga actcgccacg ctgctggcgc
     5221 ggcccggagc cgcggggcag cccgacctcg cggccctgct gaggcccgcc cgcccggcgg
     5281 cccccggcgc cttctccgcc gagctcctcg cagccgcagc cctgaccgga ctgctcgccg
     5341 cccgcgagga cggcgtcgcc gaccgcgccg cggtggaact cgccgaagcc gccgaggcgc
     5401 tgcccgccga ccaccccctg ctgcccgccg tactcagcga atcgggcctc ttccgcgcca
     5461 cccgggcggc ccgcgccgac gagctcgcgg ccctgcgcga ggccgtcgag gacgtcgtac
     5521 gggcggccgc cctctgcccg cccggcagcg cgcaccgggc gccgctgctg ctccgcgcgg
     5581 ccgccgtgct gtgcgcgcac agcgacgcgc tggacgcggc cgacccggcc ggccccgccg
     5641 cccccggctc ccgtacgagc tccctcgacc gcggcatcga cctgctgtcc ggcgcggtcg
     5701 acgaggcggg gccgagcttc cacggggccc gggcccgctg ccggtacggg ctggggagcc
     5761 tgctgctcac ccgcttccgg cgcacccgcg accgggccga cctcgaccgg gccgtcggcc
     5821 tcctccggga cgcccgcacg gccgtcctct cccgcccggg cgacccgttc acggtgctcc
     5881 tcacccgggc cctggccgag gcgctgcggg cccacggtcc cgaggacccg gaccaccgcg
     5941 cgcagtcccg ggaggcggcc aagtccgtcc tcgcggcgca cggccgggcg gtgctgctcc
     6001 agaccggcac cgagaccgcc ctcgactccg cccgcgcggc cggctccgac atgatgcgcc
     6061 tggtcgagtg gtgcctcacg gacggccgta cggaagaggc gctggaagcc ctggaactgg
     6121 ggcgcggact ggtgctgaac gcggcgaccg tcgccgcctc cgtacccgaa ctgctggagc
     6181 gggagggccg gccggagctg gcgcaggcgt ggcggcgggc cgatcccggc cgggtgcccg
     6241 gtacacctgc cgacggcccc gtggtcatcc ccgacggact gcggctgctc gtgctccagg
     6301 cgctggaggg cggcccggcg gaacgccgca tcctctccgc gcccacaccg gccgagatcg
     6361 gccgggcgct gcggacggtc ggtcacgacg cgctggtcca cctgatcccg ggccgggacg
     6421 ggtccggcga cgccctgatc gtgaccgcga ccggagcggt ggagcggctg cggctgccgg
     6481 ggctgtgcgt caccgacgac ggcccggcgg ccgcgtacgg cgaggccctc caggagttcg
     6541 ccgcggccac ccgggagccg gtcgtgctgc cgggggagga cgacccggcc gtgatgtggg
     6601 agctctaccg gcgcggccgc aagcgcctcg gccgggcctc ggaccggtgg cgcggcgccc
     6661 tggaaccgct ctgctcctgg gccggcgaag tggcgatggc cgcggtgatc gagcacgtcg
     6721 gggcggggcg gcggcaccgg ccggcccggc tggtgctgtc cccggtgggc atgctcggga
     6781 tggtcccctg gcacgccgcg cgactgccgg gcgcgcccgg ggtgtccgga gagcccggcg
     6841 gcggctacgc ctgcggccgg gcggtgatct cgtactgctc cacgtcccgc cagctggtgg
     6901 aggtggcggc ccgggcgcgg ctgccgtgga acggcgctca ggcggtggtc gccgacccgg
     6961 gcggcacccc ggccatgcac gaggaggccc ggctgatcgc ggcgctgtac cccggggcca
     7021 ccgtcgtcgg gccgatcgac gacgtgcccg agccgggcgg ccccgggagc cgcccgccgt
     7081 cccggccggc cacggcggcg gcggtggcgc cgctgctgcc gggccgcggc gggtccagcg
     7141 ttgccgtctg ccacgtcaac tgccacgcca ccgcccgggc gacgccctcc gcgtccagcc
     7201 tcgacctgca ccccgccgcg cctgtgccgc aggtgctgac cctggcggag atccaggccc
     7261 tcgcccacgg ccgcgacccg tcggcgcccg gcggtctgct ggtcctcgcc aactgcacca
     7321 gcgacctgac cctggcagac tacgacgagg cgctgaccct gtcgacggcg ttcctcacgg
     7381 cgggcgccgc ctcggtggtc ggctccctct gggcgatcgc cgacgacatc cgcacctcga
     7441 tggtgatgta cgtgttccac cactacctca ccggccgcgg actgcccggg cacccggagg
     7501 cggtgggctc gccggccgac gcgctgcgcg ccgcgcagct ctggatgctc gacccgcacc
     7561 ggatcgtccc gcccgcgctg tccgccgtac tggaggagcg tcccggactc gacctcgacg
     7621 ccccgcacat ctgggccgca tttacccacc acgggcactg acgtcactcc attaacgtat
     7681 tttgtcatag cggtcgattt cggccacggc ttctgccacg atggtggcga gtaaagcctc
     7741 aaaggcgatc gggaaaaacc caggggggaa atgcggtgag gtacgatcaa gcggccatgg
     7801 tggcggccct gaaattcgcc cacagcaatc tcgacggact gaaggtcaag gagttggtcg
     7861 acaagaaggg aatcgagtgg tacatcaacc actgcgccgc gctcgcggcg acgaccggtg
     7921 tggcgtcagg gatggggggc cccgccacga tggtgctggg cgtcccggcg gacatggcca
     7981 acaccatcgc gcagcagttc cgcgtcacga tggcggtgat ctaccacaag accgggagtt
     8041 attcgctttc gttcgatgaa ttcatgaaga tcgtggccgt gtcgctcggg gtggaggtcg
     8101 gaacccaggt cgtcgtgcgg gtggcggcgg aaatcttcaa acgactcacg gcgaagatcg
     8161 cggggaagtt catccccctc ctcggcggcg tcattggcgg gggcctgaat tacggcttca
     8221 tcaaggctca gggaaaggcc atgctcgcgc tggatttcga caagttatcc cgttcggcgt
     8281 agctgggtga ggcgggcggc ccggcgcgtc agatggtcgc gctcggcgag gttggatgcc
     8341 ttccgagccg cctcggcgta cagccgggcc gccgtctcca ggtcgccgtc ccgctcgtgg
     8401 aggtacgccg ccaccgcggt gtggcggggc agcgcgtcgt ccagcgccgc gagcgccgcc
     8461 agcccggcgc gcggaccgtc ggcctcgccg acggccaccg cgcggttgag ccggacgacc
     8521 gggctgtccg tcaggcgtac gagctcgtcg taccactcga cgatctgcac ccagtcggtc
     8581 tccccggcgg tgggcgcgtc ggcgtgcagt gccgcgatgg cggcctgagc ctggaactcg
     8641 cccagccggt cgcgggccag ggccgcctgc aggatcgcga cgccctcggc gatcatcacg
     8701 gtgtcccagc ggccgcggtc ctgctcggcg agcggtacga ggctgccgtc gggcccggtc
     8761 cgggcggagc gccgggcgtg gtggagcagc atgagggcga gcagcccggc cacttcggga
     8821 tggtcgatcg aggccgcgag ctgccgggtg agccggatgg cctcggcggc gaggtcgacg
     8881 tcgccggagt agccctcgtt gaagaccagg tagaggacgc gcagcacggt ggcgacatcg
     8941 ccgggctggt cgaaccgcac cccggagacg gtgcgcttgg cccggctgat gcgctgcgcc
     9001 atggtcgcct cgggcaccag gtaggcctgg gcgatctggc gggtggtcag cccgcccacg
     9061 gcgcgcagcg tgagcgcgac cgcggacgag ggtgtcagcg ccgggtgggc gcacaggaag
     9121 tacagctgga gcgtgtcgtc cacaccgggc gcgggtcccg gcgcgggctc ctcctcgacg
     9181 aggtcctcgc gccggcgccg ggcggtgtcc gaccgggccg cgtcgaggta ccggcgccag
     9241 gccacggtga tcagccagcc cttcggctcc cgcggcatgt cggccggcca gacgcggacc
     9301 gcctcgacca gcgcctcctg cagggcgtcc tcggccgccg cgaagtcggc tccgcggcgg
     9361 acgaggatcc cgagcacgct cggggtgagg ctcctgagca aggcctcgtt catcggtgag
     9421 gtcactccgt gatggtgggc ggcgcggtca ggaacgggcg cagttcgagc cactcgtgga
     9481 tcggcttccc gcccgccccg ggggcggcgg acagctctcc ggccagctcg acggcgcgct
     9541 cgtaactgtc gacgtcgatc accatccagc cggcgatgag gtccttggtc tcggcgaacg
     9601 ggccgtcggt gacgggcggg cggccctcgc cgtcgtaccg gacgaaggtc cccgtggggg
     9661 cgagcgcctg accgtcgacg aactcgccgg tcccctccag ccggtccgcg aagtcctgca
     9721 tgtaccgcat gtgggccgag atctcctccg gcgtccactg gtccatgggg acgtcgttga
     9781 ccgccgcggg ggcgccccgg tagtgcttga gaagcaggta cttggccatg gtggttctcc
     9841 tcgtacgggt gcggcccatt ctggccgcgt tcaccccggg gacggagcgg gccacgggtt
     9901 ctcgacatcg caggcggaat ttttttcgcg gcatcccgcc agcccgcgca ccccgcgcct
     9961 gccggcccgg cccccggccc ggtcgccgat actgatctcc atgcacgcca cggtcaacgc
    10021 cgccaccctg gaacgcgtcc tcgggcaccg gacccgcttc gacgcccggt tcggacagta
    10081 cttcgacagc ctcgccgggc gcttcgacct gccggtgccg agccggtacg tcccccggtg
    10141 cctggacctc ctgcgggacc tctcgatgcg cggcggcaag cggctgcggg tcgtcctgct
    10201 gtacgaggcg gcccggctgg tcaccaccga ggaggtgccg gggctcgcgg aggccgccct
    10261 gagcatcgaa ctgctccaga cccacgggct cgtccacgac gacatcatcg acgacgcgcc
    10321 cctgcgccgc ggcggcccct ccacgtacta cgcctaccgc cgggagttcc ccggccacgg
    10381 ggccaccgcc ctcgggctcg cggtgctcgc cggtgacctc gccgggttcc tctccacgca
    10441 ggtcctgctg gaggccgagg cgcccgtcgc gctccgccag gccctgctcg gcgtacacac
    10501 gcgcaccgcc gcggagaccg tggccgggca gatcgccgac ctggagcggg acgcccacgc
    10561 gctgcccgac gaggagttcc tgcacaccgt caccgacttc aagagcgcgc ggtactcgat
    10621 cctggcgccg ctgacgatgg gtctgctggc ggcgggcgag gatccggcgc cgcaccgcgc
    10681 ccggctgcac cggtacgcca ggctggtggg catcagcgag cagatgcgcg acgactgcct
    10741 cgacctcttc ggcccgttcg gcgagggcgc gggctcggac gcggtcgcgg gcgcggctcc
    10801 cgcggtcgcg gacaagtcca ccggggccga catccgctcc ggccgccgca cctacgccgt
    10861 ccgcgcggtc ctggccgccg cgaccggggc cgacgccgcc ctcgtcgaag ccgcgctggg
    10921 cgatccccgc tgcccggacg ccaccctgga acggatccgg gagatcgccc gcgccgccgg
    10981 agtggacggc cggctgaagg cggagatccg gcgccacgcg gaggaggcgg ccgccgaggc
    11041 cgcgtcctgg gagccgtact ggcgggcgga ggccgtggag ttcttccggg gtctgccgat
    11101 gtggaacgtg gaccggatgc cctgagcgcc ctcacccggc gagggcgtcc acgcgggcgc
    11161 gggcgccctc gccggcgccg tcaccggccg cctcgtcgaa gcccttgaac agcagccgga
    11221 ccgccagggt cacctcccag gcgaagacgg gcagggccgc gagcgaaccc gccacggaga
    11281 cctgctcgta ggccccgaac agcacggcgg tcgccgaggc gcagatcagc gcgccgccgg
    11341 ccagcccgag cacggcgagg gcccgcggca ccagccgcga ggtgtacatc aggcaggcca
    11401 gcaccagggt gttggccccg aggacgaagt tgggcccgag caggaacgtc cagtcgtgca
    11461 gcgccaccag ggccttcccg gccgtgacga gggaggcggc gtcggcggcg cccgacgggc
    11521 cggcggaccg tctcagcgtc acgaccgcca gcacgctgac gatgccgacc acgatgacgg
    11581 cggcctccag caggcgcccg cagacatagc cgacggcggc cgcttcgccg cgccgccgca
    11641 ggaccgggta cagcgcggcc ccggtgccga tgaccgccag cgccagcacg agttcgcaca
    11701 gcgcccccag gaacacccgg gtgtcggcgc cggatccgac gacgtagccg gggccctcca
    11761 gaacggggcg gtagagcgcg agcccgccga tcgccgcgac ctccgtgacg aggaacaacg
    11821 cccccgcgac gaccgcgagc ctcctggttt cactcatgcg gaacagcccc tccctcgatg
    11881 ggtgtacggc gtacacccgg catctggcgc tcacggtagg tgtacgtcgt acactcgtca
    11941 aggcgggatg ccgtatccac gcccgcccgc cgggcggaag cgacgaccag ggagaaccga
    12001 catgccggcc gacgtgccag ccgaggagtc acgccggacc cccttgagcc gggaccgggt
    12061 gctgcgcgcc gccgtcgcct tcgccgacgg cgccgggatc gaggcgctga gcatgcgcag
    12121 gctcgcccag gaactgggcg tcgtgccgat ggcgctctac aagcacgtgg ccaacaagga
    12181 ggaactcctc gacggcatgg tggaggccgt cgtcgcgggc ctcgaccccc atgtgccggg
    12241 agccgactgg aagagcgcgg tccgccgccg gatcctcggg gcccgcgacg ccctcgtgcg
    12301 gcacgcctgg gcggcccagg tgatccgctc gcgcaccagc ccgacaccgg ccgtgctcgc
    12361 gtacctggac tccgtgatcg ggatgttccg ggccggtggc ttctcgctcg acctcaccca
    12421 ccacgcgatg cacgccctcg gcagccgggt gctgggcctc accgaggaac tgttcgacgc
    12481 cccgccgagc cccggaccac gagcgacggc gacggcgccg gtgtcagcgc cggcagcgga
    12541 cccggcgcag acggccgcgc gcgaggcgat ggccctgcgg tacccccatg tcaccgagct
    12601 ggccggggcg gtggcccatg accggagttc cgtcgtgggg ggccggggct gcgacgaccg
    12661 gttcgagttc gagttcgctc tggacctcct cctcgacgga ttcgaacgcc tccacgggca
    12721 gggctggacg tcggcccccc gtccgtgacg cggatccgca cggtgccgca ggatgggggc
    12781 atggagttcg cggaactgga ggagcgggcg cgtacgctcg cggcgtcggg cggcaggcgg
    12841 atcctcggga tcgccggacc gcccggggcg ggaaagtcga cactggccgc gcgcctcgcc
    12901 cgggccctcg gggccgaact ggccgtcgcc gtaccgatgg acgggttcca cctcgctcag
    12961 gccgagctcg tccggctcgg ccgggcggac cgcaagggcg cgcccgacac cttcgacgcc
    13021 gccgggtacg cggcgctgct gcggcggctg cgcgccgccc ccggggaggg ggccggggcg
    13081 gtctacgccc cggccttcga ccgggccctg gaagagccgg tcgccgggag catccgggtc
    13141 ggcccggccg tcagcctggt gatcaccgag ggcaactacc tgctgtacgg ggcgggggag
    13201 tgggcgcagg tacggccgct cctcgacgag gcttggttcc tcgcccccga cgacgcggtc
    13261 cgcgtccggc ggctcgtcga ccgccacgtc cgtcacgggc gggaccgggc ggccgccgag
    13321 gagtgggtgt cccgctcgga cgagtcgaac gcccggctgg tcgccccggg ccgggcggga
    13381 gcggacctgg tgctggaatg aggcccgtta gggttgcccc gtgacagcgg agagcggagc
    13441 cctgatcggc gggcggtacc ggctggttga gctccggggc cggggcggca tggggcgcgt
    13501 gtggcggggc ctggacgagc ggctggaccg tgaggtcgcc gtcaaggaga tcgtgttccc
    13561 ggacggcgtc gacgaggaac ggcgcgaggc cctgctccac cggttcgtgc gcgaggccag
    13621 ggcggcggcg cggctcaacg accccgggat catcacggtg cacgacgtgg tcgagcacga
    13681 gggcgctccc gtcatcgtca tggagtacgt gaccggccca tcgctcgcgg cccaagtggc
    13741 gcgcggcggg gggatgccgg tgcggcgcgt cgccgagctg ggcgtcctga tggtgaaggc
    13801 gctgcggcgg gcgcacgccg cgggcatcgt ccaccgcgac ctcaagccgg acaacgtgct
    13861 gctcatggac gaccgggtga tcatcacgga cttcgggatc gcccacgtgg cggacgccac
    13921 gatgaccctc acccgcaccg gaacccttct cggcacgccc gcctacatgg cgcccgagca
    13981 gctggagggc gggcctccga cgcccgccac cgatctctgg tcgctcggcg ccacgctgta
    14041 ctgcgcgctg gaggggcggc cgccgttcgt cgccgagacc ttctccgccc tgtgcgtggc
    14101 catcgtcatg caggaccctc cggtccccgg gcgggccggc ccgctggcgc ccgtactggc
    14161 cgcgctcctg acgaaggacc cggccgggcg ggccaccgcg gagcaggccc tggccgccct
    14221 ggaggccgtc gccgggggcg ccgcgcagcg ggagccgcaa ccgcaaccgc agccccaacc
    14281 ggagcagcgg cggcggcagc ggctcccggg gtcgtcgctg cgcggcgcgg gctgcttcgc
    14341 actggtctgg ctgggcaccc tgctgccgtg gaaccacatc cgcgaatggc acggattcca
    14401 gcgggagttg ctggtcggcg cgacggccgc ggtggtggcc ctggcgaacg cgggcctgcg
    14461 gccccggggg ccggccggac cggggtgggc gcggttcgcc gggctgaacc tcgcactgtt
    14521 cctggtggcg gccctgatct ggcccgtctg ggggctcccc gccgtcatcg ccaacgggct
    14581 gctcgtgggc accgtctcct ggtcgctgtg gtggtcgctc tcccgcgccg gggtgcccgc
    14641 cggggtccgc cccgacgccg tcagcgagcg aggaacccgg tgacggcggc ggcgaaggcc
    14701 gccgcgtcgt ccagccacgg atagtggccc gctcccggca gtacggtcag ctccgcttcc
    14761 gggaagacac cggcggcccg cgcggccgcg gccgccgtcg gccagaggtc acgctcaccg
    14821 gccagcagca gcaccggcgc cgcgagccgg gcgagccggg ccgccagggc ctcggtgtcg
    14881 ggggcgtacc cggcgtagaa ggcctcgctg accggcagcg aacgctgggc cggatcggcg
    14941 gcggcgtgcg cccgggcggc ggcgtcccac cgcccgtaca tcagcggctc gaaggcgggc
    15001 cggtgcgcgg ccgcctcctc gaaggagcgg gccgccttca cggcccggta ggccgggagg
    15061 gcccgcgcgt accagggttc ggcggcccgc gaacgcagga cctcctcggc gccggtgtcc
    15121 gagggcagcc cgatcgaggc gaaggacggg gtgaccagca ccagccggcg cagccgcccg
    15181 ggatgggcgg cggcgtacag ctgggccagg gatccgccgg ccgaatggcc cagcaggtcg
    15241 aaggtctcca ggcccaggtg gccgcggagc gcctcgacat cggccacgag ccggtcgacc
    15301 cggcaggtgg cgaggtccgc gggcatcgcg gaggcgccgg agccccgggt gtccgggagg
    15361 atcagggtcc ggtgcgcgcc gaggccgccg aggtccccca ggtaggcggc ggcgcgaccg
    15421 gggccgccgg gcaggcagac gagcggcggg gcgccgccgt cgccggtcac ccggtaggcc
    15481 agctcggttc cgtcgtacga agtgaagaag tgcaggtcca tgccgggtag cctgcgggcc
    15541 gccggcaccc gccgactact gttcagccag agctacatgg tcgggcgccg gacgggcccg
    15601 ccggacgggg gtggcggtgt ccgtcgagat caggctgacg gcggcggagg tggcccgcgt
    15661 cagattcgcc gtgtcgccgc tcgccgagac ggtgctgggc gtgcgcgccg cgctgacggc
    15721 cacgggccaa gccgtgcacc accggtggct ggccgaggcc cgggacgtac tccgcgatga
    15781 ccccgaactg cctttgctga gaaacctgct ggggcactgc ctgccgtcgt tcctgctccc
    15841 ggtgccgcgt gaacggctgc cctcgctgga tgaggagctg gccgacctgt gcgccacgga
    15901 tcccgcgtac ttcgcggccg aatgcgccgc cggagccggc gcgcgggccg cggggcggct
    15961 tccggccgcc gaggtcgccc tgccccggct ggccggcgcc ctgcggcgct gtcacgaccg
    16021 tctggtggcc ccgcactggg ggcggatgcg ggccgtcctc gacgccgatg tgggccggcg
    16081 cgccgtggcc ctcgtcgacg gcggggtcga ggggctgttc acgcagctgc accgcgacat
    16141 cgcctggcgc gagggcgagt tggtcgtcgg cgggcggcgc cgggccggcg ccgcgccctg
    16201 cgcggtcgaa gcctcggggc acgggctggt gctgctgccc tccgtgttcg cctggccgga
    16261 cgtactggtc gaccggtcgc cggtgacagc ggcctccatc cgctatccgg ccctcggggt
    16321 cggcctgctc tgggagccgg accgccccac ccgcgacggc gtggccgccg tcctcggggc
    16381 gacccgggcg gcgctgctgg ccgcgctcgc cgaaccgctg accaccccgg cgctggcggc
    16441 ccgcctcggg gtcaccccca gcgccgtctc ccagcacctg ggcgccctgc gcggcgcggg
    16501 cctggtctcc acgcgccggt ccgggcggac ggccctgcac ctgcgcaccg cccgcgcggt
    16561 cgacctcctg accggctgag cccgccgcgg ccgccccggc ccccgtccgg gccggtgtca
    16621 cccgtaccgc tcgtgtcgcc ccggggaacc aggggaacga tcttccctgc ccgttcgtct
    16681 ggattgccca ggactgtccg tgcgcatgag gggagcaccg tcccatggcc cgacccgctc
    16741 cgacgcccgc ccggtcgcgg cgacgccgtc gtatcgcggt cgccggggcc gcgctgtgcg
    16801 cgggcctgtt cgtgctgctg gcggtcctcg tcaccgcccg gcacggcgcc ccgtacccgc
    16861 tggacagcgc cgcgcaccgc tggtccgtac ggcaccggcc cgccgtcgcc gtcgcgttcg
    16921 cgcgggccgt cacctcgacc ggcagcggcc tgttccccta cgtgtgcgcc gccgcggcgg
    16981 gggtcatcgc cgggcgcggc acccgcgagc ggctgtgggg tgcggccgcc gcgctgctct
    17041 tcctcggctt cgcccaggcg gtccgcttcg gtgtgctcca cctgatcggc cggccccggc
    17101 ctcccctcgc ggactgggcc accgtggccc acgaccactc cttcccctcc ggccacacca
    17161 ccgcctccgc cctcgcggcc gggctgctgg cctgggcact cgtacgtcgc gccggtcccg
    17221 ccgccgccgc gatcccctgc gtgatcctgg cgggctgggc cgtcgccgtc gggctgaccc
    17281 ggatctacct cggggtgcac tggcccacgg atgtcctcgc cggatggctc tacgcgctca
    17341 cctggttcgc cgtcggctac gccgtcttcc cgtacgtcct gcggatgttc acggacaccg
    17401 actgacaccg cacccgaaag gacgtgggcc gatgtgggct gccggggagg cgtacgaacc
    17461 gtacgtcgga cggtggagcc ggctggtcgc cgccgagttc gtccgccggc tggccgccgc
    17521 gcccggcggc agctggcgcg acatcggctg cggtacgggt gcggtcgccc gggccgtgct
    17581 gaccgcggcc gccccgcgcc gggtgatcgg cgtcgatccc gcggagagct acgtacgcca
    17641 cgcccgccgg cacctcgccg gtccccgggc cgacttcgtc gtgggcgacg cgctggccct
    17701 gccgttcccc gacgggcggg cgacggcggc cgtcagcggg ctcgtgctca acttcgtgcc
    17761 ggacccggcg cgggcggccg ccgagatggt gcgcgtcgtc gggcccggcg ggacggtggc
    17821 cgtctacctc tgggactacg gcgaaggcgg aatgcgggcc atccgtgcgt tctgggacgc
    17881 cgcccgcacg ctcgaccggc gggccgaggc cctggacgag gcggtcaggt tcccgctggc
    17941 cggccggaag ccgctgcgcg agctgctcac cggcgccggg ctggcgggcg tggagaccgg
    18001 cgagatcacc gtaccgaccc ggttcaggga cttcgacgac tactgggggc cgttcctggg
    18061 cggccagggc cccgcgcccg cctatgtggc ctcgctgccc gaggaccacc gcgcggagct
    18121 gcgggaacgg ctgcgcgcca ccctgccccg ggcctgcgac ggctcgatcc gcctgaccgc
    18181 gcgggcctgg acggcgtggg gtgcgcggcc gccgggctga gcccggtcac ccgtcggccg
    18241 caggggcagc gccagggccc agcgcgaggg cccggtgggg atgtcccacc gggccctcgc
    18301 ggggtcattc ggacggcgtg ccgaaggcgt gcaccgccct gctgaacgcg gtcatgcaag
    18361 gcgcgcagta gcgctcggcg gcggggtcgg ccgccggtgg aggggtctgg tcggggttga
    18421 ggagggatcc acacagggtg ctgaaggtcg tgtccttcgc tatgacgtgc cacaggagct
    18481 ggcatcggtc ggctatggac tcggcgcgca tctcgtacat gggcgtacct ttccgcgcta
    18541 gcgcgggcag aggaacggaa ccggcctgtt gtccatgaga gccccccgtg acgaatgcgg
    18601 ccaatgtggg tagaccaaca gaaggaaaac cagttggagc aggtttagcc gagcagggag
    18661 gagaccgtcg atggcatggg cttcgtggac gacgacaggg gtctttccgg gggccggagg
    18721 ggtccggacc gaggaggtcg ggatcatttc gggagacctg accgtgcaca ccacctggac
    18781 gggcgcccaa gcccaggtgg cggtgcagta cagcagctcg tcggactggt tcaccctgtc
    18841 cggcagcccc gtggaatgcg tgtcggaacc ggagagccgg gacctgcacc aggccgtggt
    18901 ggaggcggtc cgtggtggag gcggcagcgg cgttccaccc cattgggcca ctttcgcggc
    18961 ctgacggaca cagcctgata acgcctcgcg acctcccgga gtggaggatc gttcagcctt
    19021 gtatgaaagc catgagtccc ggggccacga tgcccgccac cctccccgcc cgtccgcggc
    19081 cacccgcagc cacggcggcg gcgggtggcc ggccggacac ggtcaccgcc acgggcacgc
    19141 cgatctacga cgcgctcatc gaccagtggt cccgggaggg ccgtgagctc cccctgggca
    19201 tagaaccgac cggccgcacc cccgtgccct ccccctcgcg tcagttcgcg gcccagccgc
    19261 cgtccagcgg cagggagatc ccggtgatgt agccggtgtg gggcccgcac agccagagcg
    19321 cggccgccgc cacctcctcg ggctcgatca gccgtttgat cgcggaccgg gtcagcagca
    19381 cgtccgccac cacgtccgcg gcgccgatgc cgtgcgcggc ggcctggtcc gcgatctggc
    19441 cctcgaccag gggggtgcgc acatagccgg ggctgacgca gttgctggtc accccgtacg
    19501 gggccccctc cagggcggtg accttgctca gcccctccag cccgtgcttg gccgcgacgt
    19561 aggcggattt gtaggcgctg gcccgcagcc cgtgcacgct ggagatgttg accacccggc
    19621 cccaccccga tgcgtacatg tgcggcagca cccggcgcag cagcaggaac ggcgcggtga
    19681 ccatcacctg ctggatcagg gcgaagcgct cgacggggaa ctgcgtgatc ggcgccacgt
    19741 gctggagccc cgcgctgttg accaggatgt ccacttgggc gggcagctcc tcgatggccg
    19801 ccgggtcggc gaggtcggcc acgtgcgccc gcccccggac gagacgggcc acggacgccg
    19861 ccgaaggcgc gtcgacgtcc acgacgtgca cggcggcgcc cgccgccgcc agggccaccg
    19921 cgcaggcccg gccgattccg ctgccgccac cggtcaccaa agcgacgcgc ccccgcaggt
    19981 ccacccccgc ggggccgggc gcgggcaggg gaagcgcggg aggaagttta ctcgtcatgg
    20041 ttcgcaacag taaggacggc ccgcccgcgc gcccatggcg tggcgcacca cactcccggc
    20101 cggggcagtg tcggcggccg ccatacgggg cgggagtccg ccgtcccccg ggagccgggt
    20161 ccgctcaggc atggtgcgcg ggccccgtcg tcttctacgg tgcctccagc actcaccacc
    20221 tggaggcacc ggatgacccc tgacatagac accgccgagc tcgtcgccgc cgtcaacacc
    20281 gtcgagcggg cccgaaacct gttgggggaa gcccgcgacg agctcggcgg ggcgggggtg
    20341 tcgcgggacc aggagtggac ggccgcggga agcccggtgc agacgctcca gggcgccgat
    20401 gacatgcacc ggggatccgg tcagttcctg gacgacctcg ccctggccct gggctacgcc
    20461 gccgcgggcc tggccgagca ggccctgcgt cagcgcgagc gcgccggcca ggggttcctc
    20521 gggctgagcg gtgcggaccg gatggcccgg ccgctgcccg cgcccacggt cgaggccctc
    20581 gaactcctgc gcggtctgga cctgctcacc ccggagttcc gcgaacggat cacgggggcg
    20641 ctggaggcgg aggccgccac ctacccggac ccggcgccgc agcggcccct gcggctgggc
    20701 acctccgggc tcaccccgac ggccggctga ccgccccgct cagggggagc cggggcggcg
    20761 ggcccgggtc ggctgggcga gggactgctg gccgcccgag ggcagcatcc gtacctcgcc
    20821 ctggtcactg atctccgccc gtacgatccc ggtggagtcg gcgtagaccg gatggccgcc
    20881 cggccccttc tgcgcggtgc gcgagacgac cacgaggtcc tcgccctcac cctcgggctc
    20941 gccgctgccg aacaccagct cgtagcggtc ctcgtggtcc tcgctcaccg atgtgcctcc
    21001 cggtccccgc cgccggcccg cgccgacgga ctgtcaccaa cctgcaccat cggatgccgg
    21061 ggccggacac accacgcggt actcaggtcc gaccagggga ttcaggagga cccgtgcgtc
    21121 agcgc
//
