LOCUS       NZ_BMVE01000003        27227 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000003
VERSION     NZ_BMVE01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 698120)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 27227
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27227
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..27227
                     /SMILES="C(C)=CCC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27227
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3153:7227](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3154..7227
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     gene            54..3047
                     /locus_tag="IE248_RS10130"
                     /old_locus_tag="GCM10010336_20600"
     CDS             54..3047
                     /NRPS_PKS="Domain: PKS_AT (1-238). E-value: 6.6e-85. Score:
                     277.0. Matches aSDomain:
                     nrpspksdomains_IE248_RS10130_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DHt (248-367). E-value: 8.6e-10.
                     Score: 30.8. Matches aSDomain:
                     nrpspksdomains_IE248_RS10130_PKS_DHt.1"
                     /NRPS_PKS="Domain: PKS_KR (542-720). E-value: 1.7e-56.
                     Score: 183.0. Matches aSDomain:
                     nrpspksdomains_IE248_RS10130_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (822-905). E-value: 1.1e-23.
                     Score: 75.4. Matches aSDomain:
                     nrpspksdomains_IE248_RS10130_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (915-995). E-value:
                     6e-09. Score: 28.6. Matches aSDomain:
                     nrpspksdomains_IE248_RS10130_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012901.5"
                     /locus_tag="IE248_RS10130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20600"
                     /product="type I polyketide synthase"
                     /protein_id="WP_229895287.1"
                     /sec_met_domain="PKS_AT (E-value: 7e-84, bitscore: 277.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4.6e-60, bitscore:
                     197.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 7.2e-10,
                     bitscore: 33.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3e-11, bitscore:
                     39.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQPASFAVMVSLAELWRSLGVVPDAVVGHSQGEIAAAVVAGGLS
                     LEDGARVVVLRARLIGRELAGHGGMASVALPVAVVEERLARWAGRLGVAVVNGPSATVV
                     AGDTDAVAEFVTTCEAEGVRARRLPVDYASHSAHVETLAAELEEILADVRPVNGEIPFY
                     STVEAGLVDTASLDAGYWFGNLRRPVRFQETVERLLADGFPVFVEASAHPVLTAAVQET
                     AESMGRKVCAVGSLRREEGGLRRFLTSVAEAFVQGVDVTWPALFDDSGARLVDLPTYPF
                     QHQRYWLESSPSTTVTESAAASGIESWRYRVAWKGLSLPEPVRLDGRWLLVVPEDLDAD
                     GTRVAHDVEHALTTHGATVSRLTVDVTATDRTDLAARLTTTAAEEQEPLVGILSLLGTD
                     ERQHPDHPGVDRATAGTMLLAQACADLDADVARGVEPKLWVVTRGAVAVSPAERPSSAG
                     AQVWGLGRCAALELPTRWGGMVDLPRAARDTGRQGRQLVRVLSETSAEDQVALRASGAY
                     GRRLLPASSPSASARRAAMGGYQPRGTVLVTGGTGSLGGHLARWLARNGAEHIILAGRR
                     GEGAPGAAELSAEIKELGAEVTVAACDVADRNALRDLLDALPAGQPLSAVFHAAGVPHS
                     APLAETDVAGLAAVVSGKVVGARHLHDLTREKELDAFVLYASGAGVWGSGGQSAYGAAN
                     AALDALAEQRRAEGLTATSVSWGLWDGGGMAGEQGEEFLTALGLRAMEPESAVAALGEA
                     LDRGDTCVSVVDVDWSRFAQSFTAFRPSPLIADLPGVRTAPDGPAGGPSEGLSGGARPG
                     GAADHGVLARLARATGDDRREILLDLVRRHAAAVLGHPGPQHIEPDAGFRTLGFSSVTA
                     VELANKLGATVGTKIPATFAFDHPNARAAAARLDVLLAVPSDEATREAEIRQALQNVPL
                     ARLRAAGLLDGLLELAGLEAESGGRADLSGGEPHRGAATPDEESALAEVDGLDAEALVD
                     LVLNQSDS"
     CDS_motif       57..110
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0001"
                     /evalue="3.20E-06"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE248_RS10130"
                     /protein_end="19"
                     /protein_start="1"
                     /score="19.9"
                     /tool="antismash"
                     /translation="LQPASFAVMVSLAELWRS"
     aSDomain        57..767
                     /ASF="Methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10130_PKS_AT.1"
                     /evalue="6.60E-85"
                     /label="IE248_RS10130_PKS_AT.1"
                     /locus_tag="IE248_RS10130"
                     /protein_end="238"
                     /protein_start="1"
                     /score="277.0"
                     /specificity="substrate consensus: mmal"
                     /specificity="PKS signature: Methoxymalonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="LQPASFAVMVSLAELWRSLGVVPDAVVGHSQGEIAAAVVAGGLSL
                     EDGARVVVLRARLIGRELAGHGGMASVALPVAVVEERLARWAGRLGVAVVNGPSATVVA
                     GDTDAVAEFVTTCEAEGVRARRLPVDYASHSAHVETLAAELEEILADVRPVNGEIPFYS
                     TVEAGLVDTASLDAGYWFGNLRRPVRFQETVERLLADGFPVFVEASAHPVLTAAVQETA
                     ESMGRKVCAVGSLRR"
     aSModule        57..2768
                     /complete
                     /domains="nrpspksdomains_IE248_RS10130_PKS_AT.1"
                     /domains="nrpspksdomains_IE248_RS10130_PKS_DHt.1"
                     /domains="nrpspksdomains_IE248_RS10130_PKS_KR.1"
                     /domains="nrpspksdomains_IE248_RS10130_PKS_PP.1"
                     /locus_tags="IE248_RS10130"
                     /monomer_pairings="mmal -> Me-ccmal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS_motif       114..224
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0002"
                     /evalue="2.90E-17"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="IE248_RS10130"
                     /protein_end="57"
                     /protein_start="20"
                     /score="54.5"
                     /tool="antismash"
                     /translation="GVVPDAVVGHSQGEIAAAVVAGGLSLEDGARVVVLRA"
     CDS_motif       333..374
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0003"
                     /evalue="4.10E-03"
                     /label="PKSI-AT-mM_m5"
                     /locus_tag="IE248_RS10130"
                     /protein_end="107"
                     /protein_start="93"
                     /score="9.6"
                     /tool="antismash"
                     /translation="AVVNGPSATVVAGD"
     CDS_motif       441..473
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0004"
                     /evalue="3.60E-04"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="IE248_RS10130"
                     /protein_end="140"
                     /protein_start="129"
                     /score="13.2"
                     /tool="antismash"
                     /translation="VDYASHSAHVE"
     CDS_motif       579..626
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0005"
                     /evalue="1.50E-05"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="IE248_RS10130"
                     /protein_end="191"
                     /protein_start="175"
                     /score="17.0"
                     /tool="antismash"
                     /translation="LDAGYWFGNLRRPVRF"
     aSDomain        798..1154
                     /aSDomain="PKS_DHt"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10130_PKS_DHt.1"
                     /evalue="8.60E-10"
                     /label="IE248_RS10130_PKS_DHt.1"
                     /locus_tag="IE248_RS10130"
                     /protein_end="367"
                     /protein_start="248"
                     /score="30.8"
                     /tool="antismash"
                     /translation="SVAEAFVQGVDVTWPALFDDSGARLVDLPTYPFQHQRYWLESSPS
                     TTVTESAAASGIESWRYRVAWKGLSLPEPVRLDGRWLLVVPEDLDADGTRVAHDVEHAL
                     TTHGATVSRLTVDVT"
     aSDomain        1680..2213
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10130_PKS_KR.1"
                     /evalue="1.70E-56"
                     /label="IE248_RS10130_PKS_KR.1"
                     /locus_tag="IE248_RS10130"
                     /protein_end="720"
                     /protein_start="542"
                     /score="183.0"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="GTVLVTGGTGSLGGHLARWLARNGAEHIILAGRRGEGAPGAAELS
                     AEIKELGAEVTVAACDVADRNALRDLLDALPAGQPLSAVFHAAGVPHSAPLAETDVAGL
                     AAVVSGKVVGARHLHDLTREKELDAFVLYASGAGVWGSGGQSAYGAANAALDALAEQRR
                     AEGLTATSVSWGLWD"
     CDS_motif       1683..1781
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0006"
                     /evalue="6.60E-14"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE248_RS10130"
                     /protein_end="576"
                     /protein_start="543"
                     /score="44.4"
                     /tool="antismash"
                     /translation="TVLVTGGTGSLGGHLARWLARNGAEHIILAGRR"
     CDS_motif       2058..2168
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0007"
                     /evalue="7.40E-17"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE248_RS10130"
                     /protein_end="705"
                     /protein_start="668"
                     /score="53.9"
                     /tool="antismash"
                     /translation="LDAFVLYASGAGVWGSGGQSAYGAANAALDALAEQRR"
     aSDomain        2520..2768
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10130_PKS_PP.1"
                     /evalue="1.10E-23"
                     /label="IE248_RS10130_PKS_PP.1"
                     /locus_tag="IE248_RS10130"
                     /protein_end="905"
                     /protein_start="822"
                     /score="75.4"
                     /tool="antismash"
                     /translation="LARATGDDRREILLDLVRRHAAAVLGHPGPQHIEPDAGFRTLGFS
                     SVTAVELANKLGATVGTKIPATFAFDHPNARAAAARLD"
     CDS_motif       2580..2669
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10130_0008"
                     /evalue="2.20E+01"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE248_RS10130"
                     /protein_end="872"
                     /protein_start="842"
                     /score="-2.3"
                     /tool="antismash"
                     /translation="AAAVLGHPGPQHIEPDAGFRTLGFSSVTAV"
     aSDomain        2799..3038
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10130_PKS_Docking_Cterm.
                     1"
                     /evalue="6.00E-09"
                     /label="IE248_RS10130_PKS_Docking_Cterm.1"
                     /locus_tag="IE248_RS10130"
                     /protein_end="995"
                     /protein_start="915"
                     /score="28.6"
                     /tool="antismash"
                     /translation="TREAEIRQALQNVPLARLRAAGLLDGLLELAGLEAESGGRADLSG
                     GEPHRGAATPDEESALAEVDGLDAEALVDLVLNQS"
     gene            3154..7227
                     /locus_tag="IE248_RS10135"
                     /old_locus_tag="GCM10010336_20610"
     CDS             3154..7227
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (36-466). E-value:
                     6.8e-176. Score: 577.2. Matches aSDomain:
                     nrpspksdomains_IE248_RS10135_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (578-888). E-value: 4e-109.
                     Score: 356.5. Matches aSDomain:
                     nrpspksdomains_IE248_RS10135_PKS_AT.1"
                     /NRPS_PKS="Domain: ACP (985-1055). E-value: 3.3e-26. Score:
                     83.4. Matches aSDomain: nrpspksdomains_IE248_RS10135_ACP.1"
                     /NRPS_PKS="Domain: Thioesterase (1143-1354). E-value:
                     1.8e-39. Score: 128.4. Matches aSDomain:
                     nrpspksdomains_IE248_RS10135_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743409.1"
                     /locus_tag="IE248_RS10135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20610"
                     /product="type I polyketide synthase"
                     /protein_id="WP_190030527.1"
                     /sec_met_domain="mod_KS (E-value: 1.6e-218, bitscore:
                     720.9, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.7e-90, bitscore:
                     298.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.3e-108, bitscore:
                     356.5, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-14, bitscore:
                     49.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 5.8e-28, bitscore:
                     93.9, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALSQEKVLEALRTSVKDAERLRKRNRELLAARHEPIAIVGMACR
                     YPGGVRSPEDLWELVVSGTDAVGPFPEDRGWDVERIYDLDPSVPGTTYCREGGFLYDAG
                     DFDAAFFGIGPREATVMDPQQRQLLEASWEALEQARLDPRALRGSQGGVFVGAANQGYV
                     PGDAAASGRLPEGADGYLLTGNADAVLSGRISYFLGLEGPSMTVETACSSSLVALHLAV
                     QALRREECEFALAGGVAVLANPAAYVEFARQRGLAPDGRCKAFDDAADGTGWAEGVGVL
                     VVERLSDAVRKGHRVLAVVRGTAVNQDGASSGLSVPNGPSQQRVIRRALADARLKAGQI
                     DAVEAHGTGTRLGDPIEAQALLHAYGEERSPERPLWVGSLKSNFGHAQAAAGVGGVIKT
                     VMALRHGVLPRTLHVKSPTRHVDWGDGQVRLLTETVPWPRTGAPRRAGVSAFGVSGTNG
                     HVILEEAPPAQLEEERPAVAGRPGLVPWTLSGRTGPALREQAARLAAHLEQHPGLDPLD
                     VGFSLAMTRTHFEHRTVLLANASAEGGSRAETLGALKAMAEDRDPGGAVRDTVQGEGRT
                     AFLFSGQGSQRPGMAQQLYAQYPAFARELDTIAEHLDAHLDRPLSTVMFAEAGSPEAAL
                     LDGTHYAQAALFAVEVALFRLLEGWGLRPDVLLGHSVGELAAAHVAGVFGLADACALVA
                     ARGRLMQELPAGGAMLSVRAAEHEVRDLIAGQEDRIAVAAVNGPRSIVVSGDEDAVSAL
                     AEELTEYGVRTKRLNVSHAFHSPRLDSMLEPFRRVADAVEYHEPTFDVISGLTGRAAEA
                     GELTAADYWVRQARETVRFHDGVRAARARGVSTFVELGPDAVLCGLALETLEEEPAGDT
                     SAEVPGRARAALVPVMRRERPEGSTLLMALATAHARGVQVDWSRFYAGTGARHTTLPTY
                     AFQRQRFWLEAAAPVPARDAGPGAPAVGGTAGPADAEETTGSAARPALSAQDLLMLVRT
                     QAAAALGHAELEDVPADTPFGDIGFDSLAAIELSVALTGATGLEVPSSLVFEHPTPREL
                     AGHLAAALTAADSDGTPAKGSDTAGESSLVAMYRRAVRLGRAEPFIGTLAELAAFRPAF
                     AADQVLAEGETLGQAAAAWQPAPVPLATADGAGPELICCAGTAVASGPEEFTALAAALD
                     NRLTVSALRQPGFRADELLPGSLDGLLDAQADAVLRHTGDRPYALLGHSAGGALAHALT
                     CRLEERGAGPTALILADVYLPSSPGAMGVWRNEMLDWVMQRSVVSIDDSRLTAMGAYNR
                     MLLEWVPRPTKAPVLFLRATEPVGQWSGEPESWRARWDGGDHTAVDVPGTHLTLMTEHA
                     RHLAATVRSWLDTL"
     aSDomain        3262..4551
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10135_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="6.80E-176"
                     /label="IE248_RS10135_PKS_KS.1"
                     /locus_tag="IE248_RS10135"
                     /protein_end="466"
                     /protein_start="36"
                     /score="577.2"
                     /tool="antismash"
                     /translation="IAIVGMACRYPGGVRSPEDLWELVVSGTDAVGPFPEDRGWDVERI
                     YDLDPSVPGTTYCREGGFLYDAGDFDAAFFGIGPREATVMDPQQRQLLEASWEALEQAR
                     LDPRALRGSQGGVFVGAANQGYVPGDAAASGRLPEGADGYLLTGNADAVLSGRISYFLG
                     LEGPSMTVETACSSSLVALHLAVQALRREECEFALAGGVAVLANPAAYVEFARQRGLAP
                     DGRCKAFDDAADGTGWAEGVGVLVVERLSDAVRKGHRVLAVVRGTAVNQDGASSGLSVP
                     NGPSQQRVIRRALADARLKAGQIDAVEAHGTGTRLGDPIEAQALLHAYGEERSPERPLW
                     VGSLKSNFGHAQAAAGVGGVIKTVMALRHGVLPRTLHVKSPTRHVDWGDGQVRLLTETV
                     PWPRTGAPRRAGVSAFGVSGTNGHVILEEAP"
     aSModule        3262..7215
                     /complete
                     /domains="nrpspksdomains_IE248_RS10135_PKS_KS.1"
                     /domains="nrpspksdomains_IE248_RS10135_PKS_AT.1"
                     /domains="nrpspksdomains_IE248_RS10135_ACP.1"
                     /domains="nrpspksdomains_IE248_RS10135_Thioesterase.1"
                     /final_module
                     /locus_tags="IE248_RS10135"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       3757..3804
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0001"
                     /evalue="6.10E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE248_RS10135"
                     /protein_end="217"
                     /protein_start="201"
                     /score="21.2"
                     /tool="antismash"
                     /translation="GPSMTVETACSSSLVA"
     CDS_motif       4180..4224
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0002"
                     /evalue="2.90E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE248_RS10135"
                     /protein_end="357"
                     /protein_start="342"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VEAHGTGTRLGDPIE"
     CDS_motif       4285..4329
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0003"
                     /evalue="9.60E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE248_RS10135"
                     /protein_end="392"
                     /protein_start="377"
                     /score="9.0"
                     /tool="antismash"
                     /translation="GSLKSNFGHAQAAAG"
     CDS_motif       4885..4938
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0004"
                     /evalue="1.10E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE248_RS10135"
                     /protein_end="595"
                     /protein_start="577"
                     /score="17.8"
                     /tool="antismash"
                     /translation="FLFSGQGSQRPGMAQQLY"
     aSDomain        4888..5817
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10135_PKS_AT.1"
                     /evalue="4.00E-109"
                     /label="IE248_RS10135_PKS_AT.1"
                     /locus_tag="IE248_RS10135"
                     /protein_end="888"
                     /protein_start="578"
                     /score="356.5"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQRPGMAQQLYAQYPAFARELDTIAEHLDAHLDRPLSTV
                     MFAEAGSPEAALLDGTHYAQAALFAVEVALFRLLEGWGLRPDVLLGHSVGELAAAHVAG
                     VFGLADACALVAARGRLMQELPAGGAMLSVRAAEHEVRDLIAGQEDRIAVAAVNGPRSI
                     VVSGDEDAVSALAEELTEYGVRTKRLNVSHAFHSPRLDSMLEPFRRVADAVEYHEPTFD
                     VISGLTGRAAEAGELTAADYWVRQARETVRFHDGVRAARARGVSTFVELGPDAVLCGLA
                     LETLEEEPAGDTSAEVPGRARAALVPVMR"
     CDS_motif       5134..5256
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0005"
                     /evalue="6.40E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE248_RS10135"
                     /protein_end="701"
                     /protein_start="660"
                     /score="73.1"
                     /tool="antismash"
                     /translation="GLRPDVLLGHSVGELAAAHVAGVFGLADACALVAARGRLMQ"
     CDS_motif       5350..5388
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0006"
                     /evalue="2.40E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE248_RS10135"
                     /protein_end="745"
                     /protein_start="732"
                     /score="14.3"
                     /tool="antismash"
                     /translation="AAVNGPRSIVVSG"
     CDS_motif       5452..5478
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0007"
                     /evalue="7.90E-03"
                     /label="PKSI-AT-M_m6"
                     /locus_tag="IE248_RS10135"
                     /protein_end="775"
                     /protein_start="766"
                     /score="9.3"
                     /tool="antismash"
                     /translation="LNVSHAFHS"
     CDS_motif       5611..5646
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0008"
                     /evalue="1.90E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE248_RS10135"
                     /protein_end="831"
                     /protein_start="819"
                     /score="14.8"
                     /tool="antismash"
                     /translation="YWVRQARETVRF"
     aSDomain        6109..6318
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10135_ACP.1"
                     /evalue="3.30E-26"
                     /label="IE248_RS10135_ACP.1"
                     /locus_tag="IE248_RS10135"
                     /protein_end="1055"
                     /protein_start="985"
                     /score="83.4"
                     /tool="antismash"
                     /translation="LVRTQAAAALGHAELEDVPADTPFGDIGFDSLAAIELSVALTGAT
                     GLEVPSSLVFEHPTPRELAGHLAAA"
     CDS_motif       6361..6390
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0009"
                     /evalue="1.30E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE248_RS10135"
                     /protein_end="1079"
                     /protein_start="1069"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="DTAGESSLVA"
     aSDomain        6583..7215
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10135_Thioesterase.1"
                     /evalue="1.80E-39"
                     /label="IE248_RS10135_Thioesterase.1"
                     /locus_tag="IE248_RS10135"
                     /protein_end="1354"
                     /protein_start="1143"
                     /score="128.4"
                     /tool="antismash"
                     /translation="ICCAGTAVASGPEEFTALAAALDNRLTVSALRQPGFRADELLPGS
                     LDGLLDAQADAVLRHTGDRPYALLGHSAGGALAHALTCRLEERGAGPTALILADVYLPS
                     SPGAMGVWRNEMLDWVMQRSVVSIDDSRLTAMGAYNRMLLEWVPRPTKAPVLFLRATEP
                     VGQWSGEPESWRARWDGGDHTAVDVPGTHLTLMTEHARHLAATVRSWL"
     CDS_motif       6769..6837
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0010"
                     /evalue="1.60E-08"
                     /label="NRPS-te1"
                     /locus_tag="IE248_RS10135"
                     /protein_end="1228"
                     /protein_start="1205"
                     /score="27.0"
                     /tool="antismash"
                     /translation="DRPYALLGHSAGGALAHALTCRL"
     CDS_motif       7180..7206
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10135_0011"
                     /evalue="4.10E+01"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE248_RS10135"
                     /protein_end="1351"
                     /protein_start="1342"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="ARHLAATVR"
     gene            7309..8532
                     /locus_tag="IE248_RS10140"
                     /old_locus_tag="GCM10010336_20620"
     CDS             7309..8532
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04515.1"
                     /locus_tag="IE248_RS10140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20620"
                     /product="P450-derived glycosyltransferase activator"
                     /protein_id="WP_190030528.1"
                     /transl_table=11
                     /translation="MTAQWTIPSALGRRLQRTYVGYWFAGTHGDPYALILRAQRDDTTP
                     YEEEVRARGPVFRSEVLDTWVIADGALARSVLTDARFGALTRAGGRHRAELLPPAGPET
                     GPARAREHGGVSAGADPAVSAVSAQDEVAVEAIAEQVSRTLLGGLGAGFDLVADFTRRL
                     PAQVLAEFLGLPAARRGRFEELLAGCARSLDSRLCPQTLDITRTGLGAAAELRDLLARH
                     LGDGGPRSAQAALALAVEVAAPAGALICNTFEVLGSSPGQWDALCRNPDEADAVISETW
                     WRRPPVRVESRIAQQDVELAGVPIPADGHVAILVAAAQRDPAVTPGPTENGTSVALGLL
                     GEAHSTSAARTVRALSRGALRVLAQEAPDLRPSGTAVRLRRAPVTLGHARLPVARTGSG
                     ALTHPGAA"
     gene            8576..9853
                     /locus_tag="IE248_RS10145"
                     /old_locus_tag="GCM10010336_20630"
     CDS             8576..9853
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743407.1"
                     /locus_tag="IE248_RS10145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20630"
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_190030529.1"
                     /sec_met_domain="MGT (E-value: 1.8e-147, bitscore: 486.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLMTSIAHNTHYYHLVPLAWALKAAGHEVRVASQPRITDIITG
                     SGLTAAPVGDDKDMMELFAEIGGDITPYQEGLDFAEERPEARSWEHLLGQQTVLTSMCF
                     APLNGESTMDDIVALARSWQPDLVIWETFTYAGAVAAHAVGAAHARILWGPDVIGQARE
                     RFLEAKAEQAPEHREDPMAEWLGWTLERLGLPAAGDGLEELLNGQWVIDPGPKSVRLDL
                     REPILPMRFVPYNGPAVVPDWLSEQPKRPRVCLTQGVSGRETHGKDIVRFQDLLTALGD
                     LDIEIVATLDSTQRENLTEVPDNVRIVDFISMDVLLPSCAAIIYHGGAGTSATALLHGV
                     PQIVIGAHWDVPVRARQLDELGAGIFIRPEDLDAATLRAAVRRVLTEPSLQQTADRLRA
                     EMRSNPTPAETVPVLERLTRSHRQSR"
     gene            9967..10713
                     /locus_tag="IE248_RS10150"
                     /old_locus_tag="GCM10010336_20640"
     CDS             9967..10713
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-168). E-value: 2.1e-19. Score:
                     62.1. Matches aSDomain:
                     nrpspksdomains_IE248_RS10150_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743406.1"
                     /locus_tag="IE248_RS10150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20640"
                     /product="3-oxoacyl-ACP reductase family protein"
                     /protein_id="WP_190030530.1"
                     /sec_met_domain="adh_short (E-value: 9.9e-40, bitscore:
                     131.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 4.5e-34, bitscore:
                     113.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFEGQVALVTGAAKGIGRATVVRLAEAGCDIALNYHSSKSQAEE
                     AAERIAALGRKVELFPGDISRPETARQLVAAVHQKFDRIDILVNNAGMARDKLLLTMEA
                     DDIHQVIATNLVGPMFLTQAVALTMLRQRSGRIVNITSAAASKPGKGQSNYVASKGGLE
                     AFTKAMAVELGSRGILVNAVAPGIVKTDLTEALRDGAQPELLARQVIGSFAEPEAVAEA
                     VAYLASPRNTHTTGTVLTVDGGLKMV"
     aSDomain        9985..10470
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE248_RS10150_PKS_KR.1"
                     /evalue="2.10E-19"
                     /label="IE248_RS10150_PKS_KR.1"
                     /locus_tag="IE248_RS10150"
                     /protein_end="168"
                     /protein_start="6"
                     /score="62.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGAAKGIGRATVVRLAEAGCDIALNYHSSKSQAEEAAERIA
                     ALGRKVELFPGDISRPETARQLVAAVHQKFDRIDILVNNAGMARDKLLLTMEADDIHQV
                     IATNLVGPMFLTQAVALTMLRQRSGRIVNITSAAASKPGKGQSNYVASKGGLEAFTKA"
     CDS_motif       9991..10131
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10150_0001"
                     /evalue="9.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE248_RS10150"
                     /protein_end="55"
                     /protein_start="8"
                     /score="15.1"
                     /tool="antismash"
                     /translation="LVTGAAKGIGRATVVRLAEAGCDIALNYHSSKSQAEEAAERIAAL
                     GR"
     CDS_motif       10327..10380
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE248_RS10150_0002"
                     /evalue="1.10E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE248_RS10150"
                     /protein_end="138"
                     /protein_start="120"
                     /score="-1.2"
                     /tool="antismash"
                     /translation="LTQAVALTMLRQRSGRIV"
     gene            10783..11199
                     /locus_tag="IE248_RS10155"
                     /old_locus_tag="GCM10010336_20650"
     CDS             10783..11199
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024083.5"
                     /locus_tag="IE248_RS10155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20650"
                     /product="amidase domain-containing protein"
                     /protein_id="WP_190030531.1"
                     /transl_table=11
                     /translation="MRKKIDPWTGLMGDDAWGRQSGTGWDWLDQHAYHSESWARAEGLQ
                     NFLLRRGSKEVPRTEAQPGDIVFYEQVAPGTETAPGETHHAAVVTTVTPDGDIKLTQHT
                     SSFQNVSLDSREHIANRNGGEQRIRIVRPEPDWY"
     gene            11199..11639
                     /locus_tag="IE248_RS10160"
                     /old_locus_tag="GCM10010336_20660"
     CDS             11199..11639
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS10160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_20660"
                     /product="hypothetical protein"
                     /protein_id="WP_190030532.1"
                     /transl_table=11
                     /translation="MATTSPSPAASDGTVRPRAVTPGTVTAALLVPLLTVAGVATSLHT
                     QEIEHGWADRQREACRRLPFPMAEYVAGWAGVGLGLAAVAVCVLLARRLRGRYGRRLGE
                     NWPGLVAGTTVWFNVLAIPMELIQLYVVYSAAAAGINLGDGC"
     gene            complement(12352..13281)
                     /locus_tag="IE248_RS10165"
                     /old_locus_tag="GCM10010336_20670"
     CDS             complement(12352..13281)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS10165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_20670"
                     /product="hypothetical protein"
                     /protein_id="WP_190030533.1"
                     /transl_table=11
                     /translation="MAASNEVGRYVYWSDRAVRQVAEENGIELTGRQTWTLGLSFIGLQ
                     GGIGPRQRVTRNRLEEARRIESHLGTAATESLDQEPAASYVKGVGKVEFAEFAAWHTRE
                     AVVMHTRLRNVHGQRVDICLFGSKDNLRGFGPSDGFADGWTSSAAPAVEELLRTRGRQN
                     TSQWDDPQSRSVEALKIALDQGFSGTTGHTDHPETRGFTIGHAGHCEFVAEIYTDVVLD
                     PTRWNLEGDSAGAERIMVGRPMWIRTMTPNAVVRYAELRNGPGWARQRWLRPLRSLRRR
                     PQTEIAAAGQRSMVAATRGRLATPPGCG"
     gene            13585..14196
                     /locus_tag="IE248_RS10170"
                     /old_locus_tag="GCM10010336_20680"
     CDS             13585..14196
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140123.1"
                     /locus_tag="IE248_RS10170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20680"
                     /product="hypothetical protein"
                     /protein_id="WP_190030534.1"
                     /transl_table=11
                     /translation="MEADPQRLVLDYDRFVGPWVEGEAEPVPGEVLDGAVFPSGRPLPP
                     SLRRWLAYDSSLLRRSGWFRPAEESVRSWEFAPLPLGELAVVALGEGWGAPFGALSERF
                     DECSLLPGGSDSRRVLATGEPDAYGEYPVFALDVDDLPCIELMYPGLDVYLADTAGVIG
                     RSGNGYSALAGDPRYSRRMLTQARRYLAGELHELCLDWPE"
     gene            complement(14297..17233)
                     /locus_tag="IE248_RS10175"
                     /old_locus_tag="GCM10010336_20690"
     CDS             complement(14297..17233)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.5"
                     /locus_tag="IE248_RS10175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20690"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_190030535.1"
                     /transl_table=11
                     /translation="MGREAQSARLSQVLDGLERGRGAVVEIAGEPGSGKTQLACWLAEQ
                     AGRRGLPVIWARAPRAGEGPFRVFRDAAGRTGLAEGSDPADPAAWYELIRQRAAGGVLL
                     VDEMHRADPSSLELALRLIRSLSSSAPSPSPFVLVLAHRPRQSPPALLEALDLGVRTAG
                     IVRVEAGPLDVAAVAALLDRWRRPLAVGAYGAGAPDAATAPAYALPSRTGASAAVLHTA
                     SKGLPGYLRLLVAAGFDAGLWPDRAGGDEDRLLREAAPLLAELGALSGPARAAARAAAV
                     LGGTFRPADAARIAGLGARDGLAACAELVRADLVRPAGHGQRLAFRHPVVGQVAHADCE
                     LPFLLDAHRRALRMAAERGAPAVERARHAEHLVHTDGAAAARVLAEGAAETVTRAPAIA
                     ARWLRLALDALPARGREVEERAAWELAHCRALIASGHIREARALAHDLLAEGGSRPADP
                     RPAGRADDGGARLTPRLLLRAYAVCADAERLLCRYEEAEAIARTGMALLPRPLPAVLSP
                     EATELIYEYGLVHVLRGTHDRIRPLLREAARARTEAGPSASAALGVLIAFCDVFSGDIA
                     RGAPEVTRCAALVDALPDGVAGHTPDVLALLGCAELYLERFPDARRHLQRGLDAATGGA
                     QKHIRAHQLLGLTMIDQWAGRLDGAERRAVEAGELARAVGAPDVVTLATAMRAMTLVWA
                     RGRRYAGEAVALAARAVDVVALGRGWWATSAISLLAHAQLLGGDATGCLRTLRDGGGGD
                     GLPQVQPAFRPSLLALMATAALAGGDAVGAERLLADAEADAGRLGLPLQWACVHRAGAQ
                     LRSARGEHAGALELFERAAEAFRGGGLPVQHAWTLIASAPATALVRGPGAALDVLARAE
                     SMARACGAALAVEEAERVRARLSADTRPALSPHPSAGSRVADLWSALSEREREVADLAA
                     AGLRSRQIAERLFLSHRTVDSHLGSAYRKLGVSSRTALARVLGPAVPG"
     misc_feature    complement(16118..16120)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17305..17325
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.97"
                     /tool="antismash"
     gene            17560..18366
                     /locus_tag="IE248_RS10180"
                     /old_locus_tag="GCM10010336_20700"
     CDS             17560..18366
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039771.4"
                     /locus_tag="IE248_RS10180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20700"
                     /product="DUF6426 family protein"
                     /protein_id="WP_100581019.1"
                     /transl_table=11
                     /translation="MKLRSIAATAVLGAVVFTAVPAAAVPFSAYACGGSTLCQDEDPGD
                     EGGGDEGGGGGNWGGGDWGGEGGSGEGGDGGGDWSNDPGDPGNVPSDPGGSGVEIVDGP
                     IGQPIDATLPEVVVTGHATRPSAPASPGIPTTHGGGVSGPGPLVTVHSRGRVWEERGKC
                     YRNQSGSVEAKYSQGVTYTVATQTSTNISATALQMLTAQIGTQLNTTVTETYNTELTLK
                     PGESWAVYVEYQTNVYAITTSDFWGNYSTEFVNVTQPTGVVAGRAC"
     misc_feature    complement(17561..17575)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            complement(18472..22455)
                     /locus_tag="IE248_RS10185"
                     /old_locus_tag="GCM10010336_20710"
     CDS             complement(18472..22455)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024487.5"
                     /locus_tag="IE248_RS10185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20710"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_190030536.1"
                     /transl_table=11
                     /translation="MRNGHAQERRRQALLECWRAIELFSPPTIPALPRRRPAARSGPRD
                     EYVTDLAPEPGRVPPLLPWAPDHPQTGARRAPYGRMWRHEVYCGVFDLESLRQAMIAVL
                     PAGTDPDPGVPQSELVLSGQSAMFALVLDDEGRPLEDTSVISACAWATGRLFDPGPSTP
                     GWLDGFEELDDAFGGAIDDLTATAIPYGPTPPAAGTAYERSPGSEGAAGAPGAAGGGGW
                     QSLLAEILGGAAVGAVGALFGEVAGAALQGAAEPLVRRAADWVAARRHAEEQVEAGRPV
                     RAGSVPEAAAVGPDTSAQSGAGAGAGAGPRALGFADLVALTAQIADLCGVQEHLRPRVV
                     RVRSRLVHRPRDPQTKVAAAAPFLNSLLPPDLARVSAAVGKGIGPALEAYLTELDAVDV
                     GARTDVRRERGVVLEGVAPDLVPAGRWPAPARFPLALSQQFAVDRMLAGRAGTEGGMFS
                     VNGPPGTGKTTMLRDLVAALVVERAAVLATLDRPAQAFTGPVWRGRDRQGGHPRFVSRL
                     DPRLTGFEIVVTSSNNGAVENITAELPGIGALGEHWHNGPDHFSDLASALLGGPAWGLV
                     AAVLGNKANRKEFGDRFWWGRLPQKESDARKAAELPPLRGMREVLSDWIPPKPQTGGRG
                     PAAPADRGATAAAGPARPVPSWTEAVAAFRTARDEVERLRAGRTRLAGALAAVESPSAG
                     QRIADLEAAVSRADRQVTAAAAVLDRAAAATAAARTATAAAEAGHRAASAYVPRARQEL
                     ATARADLSAARELAAHHREYVTALTARHDTPPAVERGLRGGLRRLLQSAADRQAAERQQ
                     EHTQAELAHLLVQQRAALEESLEQVASAVRAESLAAGRHARSGGAVDEAADGLTAARAG
                     ERAASARESSAAASLRQARQSADSSRRDLRGAVAELDGHHRELREAARTLPSLPLGWAH
                     LGEADQELGSPWSDEAWSTARSDLFLRALDLHRAFVAGAAKKVRGNLQVLMELMAGTNG
                     AVPDEEVAHAWQTLFLLVPVVSTTFSSVGSMFARLGRESIGWVLVDEAGQATPQAAAGA
                     LWRARRAVLVGDPLQLEPVVTMPGALQRRLLRAYGVDEHWLPSATSAQAVADRTNRYGT
                     YLPAPDTGDEHVWVGSPLRVHRRCEEPMFTVSNEVAYGGLMVHGTAHKAFPDAERDGLL
                     PSRWLATDDPSRPSDAPWGERDRRAFEFVLDHLRRQGVGVERVRVIAPFRALVAECQKI
                     CRGRDGWTSELIEERCATVHRAQGKEADVVVLVLGGGRPGARDWAARTPHLLNVAASRA
                     KRRLYVIGERGLWAPLPHFDVLASELTEFHHRRDRDTWPPDGA"
     gene            complement(22559..22729)
                     /gene="rpmF"
                     /locus_tag="IE248_RS10190"
                     /old_locus_tag="GCM10010336_20720"
     CDS             complement(22559..22729)
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487568.1"
                     /locus_tag="IE248_RS10190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20720"
                     /product="50S ribosomal protein L32"
                     /protein_id="WP_190030537.1"
                     /transl_table=11
                     /translation="MAVPKRKTSRSNTRHRRAQWKATAPQLVPVTVDGSVYQVPQRLVK
                     AYERGLLRPES"
     gene            22943..24145
                     /locus_tag="IE248_RS10195"
                     /old_locus_tag="GCM10010336_20730"
     CDS             22943..24145
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063678.1"
                     /locus_tag="IE248_RS10195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20730"
                     /product="IS110 family transposase"
                     /protein_id="WP_190030538.1"
                     /transl_table=11
                     /translation="MRERKARVWTGIDAGKGHHWAAVVDETGATLWSRKVDNDEAAILT
                     ALGEILDLADEVRWAVDISGTSSALLLALLAAHGQRAVYVPGRTVNRMSGAYRGEAKTD
                     ARDAYVIAETARHRNDFAAIDVPAQLAADLALLTGHRSDLVADRTRMINRLRDVLTGIF
                     PALERAFDYSSQKGALVLLTGCQTPGAIRRRGRARLTAWLANRSVRSADSVAATALRAA
                     RAQQAALPGEEIAAQIVADLAGQILALDDRLKRIDKQIRETFCSHPQAEIIESMPGMGP
                     TLGAEFVVAAGDLSAYVDAGHLASAAGLVPVPRDSGRRTGNLHRPKRYSRRLRRVFYLS
                     AQTSIIRDGPNRDFYLKKRGEGCKHVQAVIALARRRASVLWALLRDGRVFTSAPPVTQA
                     A"
     gene            complement(24190..24426)
                     /gene="rpsR"
                     /locus_tag="IE248_RS10200"
                     /old_locus_tag="GCM10010336_20740"
     CDS             complement(24190..24426)
                     /GO_component="GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542466.1"
                     /locus_tag="IE248_RS10200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20740"
                     /product="30S ribosomal protein S18"
                     /protein_id="WP_073798032.1"
                     /transl_table=11
                     /translation="MARRQNPHKPLRSRPNPLDTAGITSIDYKDTDLLRKFVSDRGKIR
                     SRRVTRVTARQQRELAAAVKTAREMALLPYGTR"
     gene            complement(24459..25601)
                     /locus_tag="IE248_RS10205"
                     /old_locus_tag="GCM10010336_20750"
     CDS             complement(24459..25601)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1178: cobalamin synthesis protein/P47K family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850222.1"
                     /locus_tag="IE248_RS10205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20750"
                     /product="GTP-binding protein"
                     /protein_id="WP_190030539.1"
                     /transl_table=11
                     /translation="MTLPVVIVGGLHADARKEVVERLLHTVPGSIALHHDLATAAQGTV
                     LRVVRDASGELSRGETPLVNDCACCALREDLVPELERLAGSGLTRLAVVELWDSVEPKA
                     MAEVVAAHGARALELTGVITAVDPALVLPYLVNGDDLADAGLAAAATDQRTVGDTWARQ
                     LEYAPVLALVDSGEAGAEDRALLAQLHPTARRVAADSGELAALALAGFDVEAAAAAQHP
                     ACALLPQEADEAGVTTLVWHRRRPFHPERLYEALEDLCCAAARSRGRFWLADRPDTLLA
                     WDSAGGALCVENTGPWLASLPDAAWELVPPMRRAAASLDWHPDHGDCCQHLVFTSPGLD
                     RPGLEQLLESCLLTDAEYAAGPEAWKCLPAAFDSLLDPVS"
     gene            complement(25598..25846)
                     /locus_tag="IE248_RS10210"
                     /old_locus_tag="GCM10010336_20760"
     CDS             complement(25598..25846)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049846.1"
                     /locus_tag="IE248_RS10210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20760"
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_037798679.1"
                     /transl_table=11
                     /translation="MKPGIHPAYGPVVFRDKAADFAFLTRSTATSDKTVEWEDGNTYPV
                     IDVEISSRSHPFYTGTARVLDTAGRVERFQRRYGSTS"
     gene            complement(25885..26049)
                     /gene="rpmG"
                     /locus_tag="IE248_RS10215"
                     /old_locus_tag="GCM10010336_20770"
     CDS             complement(25885..26049)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005063154.1"
                     /locus_tag="IE248_RS10215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20770"
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_037798680.1"
                     /transl_table=11
                     /translation="MARNEIRPVVKLRSTAGTGYTYVTRKNRRNDPDRLVLRKFDPVVR
                     RHVDFREER"
     misc_feature    26066..26081
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.22"
                     /tool="antismash"
     misc_feature    26068..26082
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 24.05"
                     /tool="antismash"
     misc_feature    complement(26069..26084)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.1"
                     /tool="antismash"
     misc_feature    complement(26070..26081)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.41"
                     /tool="antismash"
     misc_feature    26071..26089
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            26119..26355
                     /gene="rpmB"
                     /locus_tag="IE248_RS10220"
                     /old_locus_tag="GCM10010336_20780"
     CDS             26119..26355
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240080.1"
                     /locus_tag="IE248_RS10220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20780"
                     /product="50S ribosomal protein L28"
                     /protein_id="WP_073798035.1"
                     /transl_table=11
                     /translation="MSAHCQLTGARPGFGNNISHSHRRTSRRFDPNIQSKRYWLPGEGR
                     HVRLTLSAKAVKTIDVIGIEAAVARIRARGVKV"
     gene            26355..26660
                     /gene="rpsN"
                     /locus_tag="IE248_RS10225"
                     /old_locus_tag="GCM10010336_20790"
     CDS             26355..26660
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850225.1"
                     /locus_tag="IE248_RS10225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_20790"
                     /product="30S ribosomal protein S14"
                     /protein_id="WP_037798683.1"
                     /transl_table=11
                     /translation="MARKSKIAQNEKRKATVERYAARRAELKEVLRRPSATAAERRAAL
                     AELRGQPRDASATRVRNRDSVDGRPRGHLRKFGLSRVRMREQAHAGFLPGVTKSSW"
     misc_feature    complement(26968..26982)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(27145..27159)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
ORIGIN
        1 actggcggct ggcagatgtg ctgggtgatg aggctgcgtt ggagcgggtg gaggtgctgc
       61 agccggcctc gtttgcggtg atggtgtcgc tggcggagtt gtggcggtcg ttgggtgtgg
      121 tgccggatgc ggtggtcggg cattcgcagg gggagatcgc tgccgcggtg gtggcgggtg
      181 gcctgtcgtt ggaggacggg gcccgtgtcg ttgtgctgcg tgcacggttg atcgggcgtg
      241 agctggcggg ccatggcggg atggcgtcgg tggcgttgcc agtggcggtg gtggaggagc
      301 gcctggcgcg gtgggctggg cgtttgggtg tggcggtggt caacgggccg tcggccactg
      361 tggtcgccgg tgacacggac gcggtggcgg agttcgtgac cacatgtgag gcggagggtg
      421 tgcgggcgcg gcgtctgccg gtggactatg cctcgcactc ggcgcatgtg gagacactgg
      481 cagccgagct ggaggagatc ctggccgacg tccgtccggt gaacggcgag atcccgttct
      541 actcgacggt agaggctggc ctcgtggaca cggcgtcgtt ggatgcgggg tactggttcg
      601 ggaatctgcg tcggccagtg cggttccagg aaacggtcga gcgtctcctc gctgacggtt
      661 tcccggtgtt cgtggaggcc agcgcgcacc cggtgctgac agctgcggtc caggagacag
      721 cggaatccat gggccggaag gtatgtgcgg tcggttccct gcgtcgcgag gaggggggtc
      781 tgcgtcgttt cctgacctcg gtggcggagg cgttcgtcca gggcgtcgac gtcacctggc
      841 ccgccctctt cgacgacagc ggcgcgcgtc tcgtcgacct gcccacctac cccttccagc
      901 accagcgtta ctggctcgag tcaagcccct ccacgacggt gaccgagtcc gccgcagcgt
      961 caggaatcga gagctggcgt taccgcgtgg cgtggaaggg cctgtcgttg ccggagccgg
     1021 tgcgtcttga cggccggtgg ctgctcgtcg tgcccgagga cctggacgcg gacggcacac
     1081 gtgtcgccca cgacgtcgag cacgccctca ccacccacgg cgccacggtc tcccgcctca
     1141 cggtcgacgt gacggcgacg gaccgcaccg acctggcggc gcggctcacc accaccgcgg
     1201 ccgaagagca ggaacccctc gtgggaatcc tctccctcct gggcaccgat gagcggcagc
     1261 acccggatca tccgggcgtc gaccgtgcca cggcaggcac gatgctgctc gcgcaggcgt
     1321 gcgcggatct ggacgcggac gtggcccggg gggtggagcc gaagctgtgg gtcgtgaccc
     1381 gtggggcggt cgcggtgtcc cccgccgagc gcccgtcgtc agcgggcgcc caggtctggg
     1441 gcctgggccg ctgtgcggcg ctcgaactcc ccacccggtg gggcgggatg gtggaccttc
     1501 cccgggcggc gcgggatacc ggacggcaag ggcggcagct cgtccgtgtg ctgtcggaga
     1561 ccagtgccga ggaccaggtg gcgctgcgcg cgtcgggcgc gtacggccgc aggctgctgc
     1621 ccgcctccag cccttccgca tccgcccgcc gggccgcgat gggcggctac cagccgcgcg
     1681 gcacggttct ggtgaccggc ggaaccggat ccctcggagg ccatctggca cggtggctgg
     1741 cccgcaacgg cgccgagcac atcattctgg ccgggcggcg gggcgagggc gcgccaggag
     1801 ccgcggaact gtcagcggag atcaaggagc tgggcgcgga ggtgaccgtc gcggcctgcg
     1861 acgtggcaga tcggaacgcg ttgcgggact tgctggatgc cctgccggcc gggcagccgc
     1921 tgtcggcggt gttccacgct gccggtgtcc cgcactcggc gccgctcgcc gagacggatg
     1981 tggcagggct cgccgccgta gtctcgggca aggtcgtcgg ggcgcggcat ctgcacgacc
     2041 tcaccaggga gaaggagctg gacgcgttcg tgctgtacgc gtcgggagcg ggcgtgtggg
     2101 ggagtggcgg gcagagcgca tacggagccg ccaacgccgc actggacgcg ctggccgaac
     2161 agcgccgggc ggagggactg accgccacat cggtctcctg ggggctgtgg gacggcggag
     2221 gcatggccgg cgagcagggc gaggaattcc tcaccgccct cggtctgcgg gcgatggagc
     2281 ccgagtcggc cgtcgccgcc ctgggcgagg cactggaccg gggagacacc tgtgtgagcg
     2341 tggtcgacgt cgactggtcc cggttcgccc agtcgttcac cgctttccgg cccagcccgc
     2401 tgatcgcgga cctgcccggg gtgcgtaccg cgccggacgg accggcgggc ggaccgtcgg
     2461 agggcctctc gggcggcgca cggcccggcg gcgcagccga ccatggagtg ctggcacggc
     2521 tcgcccgggc cacgggcgac gaccggcggg agatcctgct cgatctcgta cgccgccacg
     2581 ccgccgccgt cctcggtcac ccggggccgc agcacatcga gcccgacgcc gggttccgaa
     2641 cgctggggtt cagctcggtc accgccgtgg aactggcgaa caagctcggt gcgaccgtgg
     2701 gcaccaagat ccccgccacc ttcgcgttcg accaccccaa cgcccgtgcc gcggcagccc
     2761 gcctcgacgt cctgctggcg gtgccgagcg acgaggccac gcgggaggcg gagatccggc
     2821 aggcactgca gaacgtgccg ctggcccggc tgcgggccgc gggcctcctc gacggtctgc
     2881 tcgaactcgc cggactggaa gcggagtccg gcggccgggc cgacctgtcg ggcggcgagc
     2941 cgcatcgcgg cgcggccacg ccggacgagg agtccgccct ggcggaagtc gacggtctgg
     3001 acgccgaagc actggtcgac ctcgtcctca accagtccga ctcctgaccg ctgcgggcgc
     3061 cgccggggcc cgccgttccg tcgccgcctt cggccgcacg aaccacacag acctgaccgg
     3121 gccacggccc ggagctcagc aaggagacca ctcatggctc tgtcccaaga gaaggtgcta
     3181 gaggcactgc gcacctccgt caaggacgcc gaacggctgc gcaagcgcaa ccgcgaactc
     3241 ctcgcggccc gtcacgagcc catcgcgatc gtcggcatgg cctgccgcta tcccggaggg
     3301 gtccgttcgc ccgaggacct ctgggaactc gtcgtgtcgg ggaccgacgc ggtgggtccc
     3361 ttccccgagg accggggctg ggacgtggag cggatctacg acctggaccc gtcagtcccg
     3421 ggcacgacct actgccgcga gggcggattc ctgtacgacg cgggagactt cgacgcggcg
     3481 ttcttcggga taggaccgcg cgaggccacc gtgatggacc cgcagcagcg ccagctcctg
     3541 gaggcgtcct gggaagccct ggagcaggcc cggctggacc cgcgcgcgct gcgcggcagc
     3601 cagggcggtg tgttcgtcgg cgcggcgaac cagggctacg tgccgggcga cgcggccgcg
     3661 tcgggacgtc tgccggaggg ggccgacggt tacctgctca ccggcaatgc cgacgcggtc
     3721 ctgtcgggcc ggatcagcta cttcctgggc ctggaaggcc cgtccatgac cgtcgagacg
     3781 gcctgctcct cctcgctggt ggcactgcac ctggcggtgc aggcgctgcg ccgcgaggag
     3841 tgcgagttcg ccctggcggg cggagtcgcc gtgctcgcca acccggccgc ctacgtggag
     3901 ttcgcccggc agcgggggct cgccccggac gggcgctgca aggcgttcga cgacgcggcg
     3961 gacggtacgg gctgggccga gggcgtgggt gtcctggtgg tggagaggct gtcggacgcg
     4021 gtacgcaagg ggcatcgggt cctcgccgtc gtgcggggta cggcggtgaa tcaggacggt
     4081 gccagcagcg gtctgtccgt gcccaatggg ccctcccagc agcgggtcat ccgccgcgcg
     4141 ctggccgacg cccggctgaa ggccggccag atcgatgcgg tggaggcgca cggcaccggt
     4201 acccggctgg gcgaccccat cgaggcacag gccctgctgc acgcgtacgg tgaggagagg
     4261 agccccgaac gccccttgtg ggtggggtcg ttgaagtcga atttcggtca cgcgcaggcg
     4321 gcagccggag tgggcggcgt catcaagacg gtgatggcgc tgcggcacgg tgtgcttccc
     4381 cgcacgctgc atgtgaagag cccgacgcgg cacgtcgact ggggcgacgg gcaggtgcgg
     4441 ctgctgaccg agacggtgcc gtggccgcgg accggcgccc cccggcgggc aggagtctcg
     4501 gccttcggcg tgagcggcac caacggtcac gtcatcctcg aagaggcgcc gcccgcacag
     4561 ctcgaagagg agcggccggc cgtggcgggg cggccgggcc tggtcccgtg gacgctgtcc
     4621 ggccgtacgg ggccagcgct gcgcgagcag gccgcgcgcc tggcagcaca cctggaacag
     4681 cacccgggcc tcgacccgct ggacgtcggg ttctcgctcg ccatgacccg tacccacttc
     4741 gagcaccgga ccgtgctgct cgcgaatgcc tccgccgagg gcggatcccg tgccgaaacg
     4801 ctcggggcgc tgaaggcgat ggcggaagac cgcgacccgg gcggggcggt gcgggacacc
     4861 gtgcagggcg aagggcgtac cgccttcctg ttcagcgggc agggcagtca gcgacccggc
     4921 atggcgcagc agctgtacgc gcagtacccg gcgttcgcac gggagctgga cacgatcgcg
     4981 gagcatctgg acgcccatct ggaccggccg ttgtcgacgg tgatgttcgc ggaggccggt
     5041 tcgccggagg ccgcgctgct cgacggcacg cactacgccc aggccgccct gttcgccgta
     5101 gaggtcgcgt tgttccggct cctcgaaggc tgggggctgc gccccgacgt gcttctgggg
     5161 cactccgtgg gcgagctggc cgcggcccac gtggccgggg tgttcgggct ggcggacgcc
     5221 tgcgcactgg tcgccgcccg cggccggctc atgcaggaac tgccggccgg cggcgcgatg
     5281 ctctcggtcc gtgccgccga gcacgaggtg cgggacctga tcgccggaca ggaggaccgc
     5341 atcgcggtgg cggccgtcaa cgggccccgc tccatcgtcg tctccgggga cgaggacgcc
     5401 gtctcggcgc ttgccgagga gctgaccgag tacggcgtgc ggaccaagcg cctgaacgtg
     5461 agccacgcct tccactcccc tcggctggac tccatgctgg aaccgttccg ccgggtcgcg
     5521 gacgccgtgg agtaccacga gccgacgttc gacgtgatca gcggcctgac cggccgcgcg
     5581 gccgaggccg gggaactcac cgccgccgac tactgggtcc ggcaggcgag ggagaccgtc
     5641 cggttccacg acggggtgcg cgccgctcgc gcgcgcggcg tcagcacctt cgtggagctg
     5701 gggccggacg ccgtgctctg cggcctggcc ctggagaccc tggaggagga gccggccggg
     5761 gacacgtccg ccgaggtgcc cggccgggcg cgggccgcgt tggtgcccgt gatgcgtcgg
     5821 gagcggccgg agggcagtac cctcctgatg gcgctcgcca cggcccacgc gcgcggcgtg
     5881 caggtggact ggtcccggtt ctacgccggc accggtgccc gccacaccac actgcccacc
     5941 tatgccttcc agcgccagcg gttctggctg gaggcggcgg cccccgtgcc cgcgagggac
     6001 gccgggcccg gcgcgcccgc ggtgggcggg acggccggac cggccgacgc ggaggagacc
     6061 accggttcgg cggcccggcc cgcgctgagt gcgcaggacc tgctcatgct ggtgcggaca
     6121 caagcggcgg ccgcactcgg tcacgccgaa ctggaagacg taccggccga cacccccttc
     6181 ggcgacatcg gtttcgactc gctcgccgcc atcgaactga gcgtcgccct gaccggtgcc
     6241 accgggctgg aggtgccctc ctccctcgtc ttcgaacacc ccacccccag ggaactggcc
     6301 gggcacctgg cagccgccct gacggccgcc gacagcgacg gcacacctgc caaaggctcg
     6361 gacacggccg gtgagagcag cctggtggcg atgtaccggc gggccgtgcg gctcggccgg
     6421 gccgagccgt tcatcggcac actcgccgaa ctcgccgcct tccggcccgc cttcgccgcc
     6481 gatcaggtcc tcgcggaagg agaaaccctc gggcaggcgg ccgccgcatg gcagccggct
     6541 ccggtacccc tggccaccgc ggacggtgcg ggaccggagc tgatctgctg cgcgggcacg
     6601 gcggtggcgt cgggtccgga ggagttcacc gcactggccg cggccctgga caaccggctg
     6661 accgtgtcgg cgctgcgcca gcccggcttc cgcgcggacg agttgctgcc cggctccttg
     6721 gacgggctgc tcgacgccca ggcggacgcg gtgctgcggc acaccggtga caggccgtac
     6781 gccctcctcg gccactcggc gggcggggcg ctggcacacg cgctgacctg ccgactggag
     6841 gagcgcggcg cgggtcccac ggcgctgatc ctggcggacg tctatctccc cagctcgccg
     6901 ggggcgatgg gggtgtggcg caacgagatg ctcgactggg tcatgcagcg ttccgtggtg
     6961 tcgatcgacg actcccggct gacggcgatg ggcgcctaca accggatgct cctggagtgg
     7021 gtgccgaggc ccacgaaggc gccggtcctg ttcctgcgcg cgacggagcc ggtagggcag
     7081 tggtccgggg aaccggagag ctggcgggca cgctgggacg gcggcgacca caccgccgtc
     7141 gacgtgccgg gcacccacct gacgctgatg accgagcacg cccgccacct cgcggcgacc
     7201 gtccgcagct ggctcgacac cctgtgaacc gccccgggga gggctgcgcc gggcgccgga
     7261 cggctgcttc ccccgtttcc gtacaccgcg acaccttgga ggactcccgt gacagcgcag
     7321 tggaccatcc cgtccgcact cggccgcagg cttcaacgca cctacgtggg ctactggttc
     7381 gcaggaacgc atggagaccc gtacgcgctg atcctgcgcg cccagcggga cgacaccacc
     7441 ccctacgagg aggaggtccg cgcacgcgga ccggtgttcc gcagcgaggt gctggacacc
     7501 tgggtgatcg cggacggcgc cctcgcccgg tccgtcctga ccgacgcccg cttcggagcg
     7561 ctgacccgcg cgggaggacg gcaccgcgcg gaacttctcc cgccggcagg ccccgagacc
     7621 ggtccggccc gggcacggga gcacggcggc gtgtcggccg gcgccgatcc ggcggtgtcg
     7681 gctgtgtcgg cgcaggacga ggtggccgtt gaggccatcg ccgagcaggt gtcacgcacc
     7741 ctcctgggcg ggctcggcgc cggcttcgat ctcgtcgccg atttcacgcg acgcctgccg
     7801 gcgcaggtcc tggcggaatt cctggggctg cccgcggccc ggcgcggccg gttcgaggaa
     7861 ctgctggccg gctgtgcccg cagcctcgac agccggctgt gcccgcagac tctcgacatc
     7921 acacggaccg gcctgggggc agcggccgag cttcgggacc tgctcgcgcg ccacctcggc
     7981 gacggcggac cacggtccgc tcaggcggct ctcgctctgg cagtcgaggt ggccgcaccc
     8041 gccggtgcgc tcatctgcaa cacgttcgag gtgctgggca gctctcccgg gcaatgggac
     8101 gccctctgcc ggaacccgga cgaggccgac gccgtcatct ccgagacctg gtggcggcgg
     8161 ccgccggtgc gggtggaaag caggatcgcg cagcaggacg tcgaactggc cggagtaccg
     8221 atccccgcag acgggcatgt ggcgatcctc gtcgccgccg cccagcgcga cccggcggtc
     8281 accccagggc cgacggagaa cggcaccagc gtcgctctgg ggctcctcgg cgaggcgcac
     8341 tccacctctg ccgcccggac ggtccgcgcc ctctcccgcg gtgcgctgcg ggtgctcgcg
     8401 caggaggcgc cggacctgcg gccgagcggg acagcggtgc gtctcaggcg ggcgcccgtc
     8461 acgctcggcc acgcccgcct ccccgtcgcc cggacgggat ccggggcact gacccacccg
     8521 ggtgcggcat gagcacccgc gacgaacacc gactgccgaa cggggagacg agccgatgcg
     8581 cgtcctgatg acgtcgatcg cccacaacac gcactactac cacctggtgc cgctggcctg
     8641 ggccctgaaa gccgcgggcc acgaggtgcg agtggccagc cagccccgca tcaccgacat
     8701 catcaccggg tccggcctca ccgccgcacc ggtcggtgac gacaaggaca tgatggagct
     8761 gttcgccgag atcggcggag acatcactcc gtaccaggag ggactggact tcgccgagga
     8821 gcggcccgag gcacggtcct gggagcatct gctcggccag cagaccgttc tgacctcaat
     8881 gtgcttcgcg ccgctcaacg gcgagtccac gatggacgac atcgtcgcgc tggcccgctc
     8941 ctggcagccg gacctggtga tctgggaaac cttcacctac gcgggagcgg tcgccgccca
     9001 tgccgtgggc gcggcgcacg cccgcatcct gtggggcccc gatgtcatcg gtcaggcccg
     9061 ggaacggttc ctggaggcca aggcagagca ggctcccgag caccgggagg acccgatggc
     9121 cgagtggctc ggctggaccc tggagaggct gggcctcccg gcggccggag acgggctgga
     9181 ggagctgctg aacggccagt gggtcatcga cccaggcccc aagagtgtgc ggctcgacct
     9241 tcgcgagccg atcctgccca tgcgcttcgt tccctacaac ggccctgccg tcgtacccga
     9301 ctggctgtcc gagcagccga agcgaccgcg cgtctgcctc acccagggag tgtcggggcg
     9361 cgagacccac ggcaaggaca tcgtccgctt ccaggacctg ctcacggcgc tgggcgacct
     9421 cgacatcgag atcgtcgcca cgctggacag cacccagcgg gagaacctga cggaagtccc
     9481 cgacaacgtc cggatcgtcg acttcatctc gatggacgtg ctgctgccga gttgcgccgc
     9541 gatcatctac cacggtggcg ccggcacctc ggcgacagcc ctcctgcacg gcgttccaca
     9601 gatcgtcatc ggcgcgcact gggacgtgcc ggtcagggcc cggcaactcg acgagctggg
     9661 cgccggcatc ttcatccggc ccgaggacct ggacgcggcc acactgcgcg cggcggttcg
     9721 gcgagtgctc accgagcctt ccctccagca gaccgcggac cggctgcggg ccgagatgcg
     9781 gtccaacccc acccccgcgg agaccgtacc ggtgttggag cggctcaccc ggagccaccg
     9841 gcagtcccgc tgaccacccg gccggtgcac ggtgcgggac cgtgtgccgg ggcaccaccg
     9901 tcgccggcgg tcgtcggacc gccgtccggt cgtctcccgt aaccaacgga tggagcagag
     9961 cagcacatgg aattcgaagg tcaggtcgcg ctcgtgacgg gggccgccaa gggcatcggc
    10021 cgtgcgacgg tcgtccggct ggcggaagcc ggatgcgaca tcgcgctcaa ctaccacagc
    10081 tcgaagtcac aggctgagga agccgccgag cgcatcgccg cactgggccg caaggtcgaa
    10141 ctgttcccgg gtgacatctc ccgccccgag accgcacggc agctggtggc cgcggtgcac
    10201 cagaagttcg accggatcga cattctggtg aacaacgcgg gcatggcgcg ggacaagctc
    10261 ctgttgacca tggaggcgga cgacatccac caggtcatcg ccaccaacct cgtcggcccg
    10321 atgttcctca cccaggccgt cgcactcacc atgctgcgtc agcgttccgg acgcatcgtc
    10381 aacatcacct ccgcggccgc gagcaagccc ggaaaaggcc agtccaacta cgtcgcgtcc
    10441 aagggcggcc tggaggcgtt caccaaggcg atggcggtgg aactcggatc ccgtggaatc
    10501 ctcgtcaacg cggtcgctcc cggcatcgtc aagaccgatc tgaccgaggc tctccgcgac
    10561 ggggcgcagc cggaactcct ggcccggcag gtgatcgggt ccttcgccga gcctgaggcg
    10621 gtggcggagg cagtggccta cctggcgagc cctcgcaaca cgcacacgac gggcacggtc
    10681 ctcaccgtcg acggcggcct caagatggtg tgagcgccac cggacacagg accgccgccc
    10741 tggcgacggc cagggcggca gaggcgggag gaagcgggtg gcatgaggaa gaagatcgac
    10801 ccgtggacgg ggctgatggg cgacgacgcc tggggccgcc agagcgggac cggttgggac
    10861 tggctcgacc agcacgcgta ccactccgag tcatgggcac gggccgaggg actgcagaac
    10921 ttcctgctgc gccgcggcag caaggaggtg ccgaggaccg aggcacagcc cggtgacatc
    10981 gtcttctacg agcaggtggc tcccggcacg gaaaccgccc ccggcgagac ccaccacgcc
    11041 gccgtcgtaa ccacggtcac cccggacgga gacatcaagc tgacccagca cacgagctcg
    11101 ttccagaacg taagtctgga cagccgggaa cacatcgcga acaggaacgg gggcgagcag
    11161 cgcatccgca tcgtccgccc ggaaccggat tggtactgat ggccaccacc tcgccctcac
    11221 ccgccgcgag cgacggcacg gtgcgcccgc gtgccgtcac gccgggcacc gtgacggcgg
    11281 cgctgctggt gccgctgctg accgtggccg gtgtggccac ctccctgcac acgcaggaga
    11341 tcgagcacgg gtgggccgac cggcagcgcg aagcctgccg gcgcctgccc ttcccgatgg
    11401 cggagtacgt cgcggggtgg gccggtgtgg gcctcggcct ggcggcggtg gccgtgtgcg
    11461 tgctgctcgc acggcggctg cgcggacggt acggccggcg gctcggggag aactggccgg
    11521 gtctcgtcgc cggtaccact gtctggttca acgttctggc gatcccgatg gaactgatcc
    11581 agctgtacgt cgtctactcg gccgccgcgg cggggatcaa ccttggcgac gggtgctgac
    11641 gagctcgtgc acggtgggcg ggtgagacgt cggggccagt ggcctgttgc ccggcgtcaa
    11701 gctgagggca cggggaacgg cggggtggtg cctcatcgga cgctgcccga ggggatggca
    11761 gcggccggga gccgtgattc tcaagctgca accgagccgg cccgatcgag gggaagatct
    11821 tcgaatcccc atcccggcca tcactccgtt tcctagcctg gtctggggcg gtcacgggcg
    11881 aggcagcaaa ggtgtgaagc gtggctgggg gcgacttgtc ggagagggcc gacggccttg
    11941 ccgtggtcct ttcgatgtgc aggtgctcgc agtcctgaag aaggtgccca tgccatgggc
    12001 gagtgacttc gtcgccattc ggtgcggggc tcctcgggcg ccaacctttt gttgacgccg
    12061 gagggtccaa tacgttcctg acctgcacga aaacggattt ctcgtgttac gttctgcaac
    12121 cggatcgggc gcagcaatga agagatcgtc caagcccgcc aggactggat gcagggcacc
    12181 cgcttcggct aggcaaaggg ctacgacggc ccccgatccc cgtccccaac tcccgccggc
    12241 ccccctgaag ccccgcggcc gggtgcgctg aactgctggt ttgttcagaa gcccgctggg
    12301 tgcggtgctc gcacccagtc ttccggtttt ggtctggcga ttggctgaaa gtcacccaca
    12361 cccgggtggg gtcgcgagtc gcccccgcgt ggcggcgacc atgctgcgct gccccgccgc
    12421 agcgatctcg gtctgcggcc gcctcctcag ggagcgcaac ggccgcagcc agcgttgacg
    12481 ggcccatccc ggtccgttgc gcagctcggc gtagcggacg actgcgttgg gggtcatcgt
    12541 tcggatccac atcggtcttc cgaccatgat gcgttcggcg ccggccgaat cgccttcgag
    12601 gttccaccgc gtgggatcga gtacgacgtc ggtgtagatc tcggcgacga actcacagtg
    12661 tcccgcgtgg ccgatggtga agccgcgggt ctcagggtgg tccgtgtggc cggtggtgcc
    12721 agagaatccc tggtccaaag cgatcttcaa tgcctctacg gatcgggact gcgggtcgtc
    12781 ccattgggag gtgttctgcc ttcccctggt gcgcagcagc tcttcgaccg ccggcgccgc
    12841 tgaggaggtc cagccgtcgg cgaagccgtc gctcggcccg aagccgcgta ggttgtcctt
    12901 gcttccgaag aggcagatgt cgacgcgctg gccgtgcaca tttcgcagcc gagtgtgcat
    12961 gactacggct tcccgggtgt gccatgcggc gaactcggcg aactcgactt tgccgacacc
    13021 cttgacgtag gaggccgcgg gttcctggtc caggctttcc gtcgccgcgg taccgaggtg
    13081 actctcaatc cggcgcgcct cttccaggcg gttccgcgtc acacgctgtc ggggcccgat
    13141 gcctccttgg aggccgatga acgagaggcc gagggtccag gtttgccgtc cggtgagctc
    13201 gatgccgttc tcttcggcaa cttgtcggac tgctcgatcc gaccagtaga cgtatcggcc
    13261 gacctcgttg ctggctgcca tccgacctcg aattcgttgg tgcccccgta tgccggagtg
    13321 gggtcatgct ggcacggcag caccggtgcc tggcgtggtc ggcgggttcc cgcacgggac
    13381 agcctccgac ctgctaggga gtcagggttg gcagtgccgt gataccggtg catgcgccga
    13441 atcctgcctg gagggcggtg ttggggctta gggtcgtggt gaccgggtgc ttggtccggc
    13501 gctttggaag ggctgtcagg atccgtgacg tcgtcaaccg ccgctgacca tgggatcgcg
    13561 cttaccgagc gcgtcatctc cgctgtggag gctgacccgc agcggctcgt cctcgactac
    13621 gaccggttcg tggggccgtg ggtcgagggg gaggcggagc cggtgcccgg cgaggtgctt
    13681 gacggggcgg tcttccccag cgggcggccg ctgccgccca gcctgcggcg ttggctggcg
    13741 tacgacagca gcctgctgcg ccgctccggc tggttccggc cggccgagga gtcggttcgg
    13801 tcctgggagt tcgcgcccct gccgctcggc gagctggccg tggtggcgct cggcgagggc
    13861 tggggcgcgc cgttcggggc gctgtcggag cgcttcgacg agtgctccct gctgcccggc
    13921 ggatcggact cccggcgcgt gctggccacg ggcgaacccg acgcgtacgg cgagtacccg
    13981 gtgttcgcgc tcgacgtgga cgacctgccg tgcatcgagt tgatgtaccc ggggctggac
    14041 gtctacctgg cggacaccgc cggggtgatc ggccgttcgg ggaacggcta ttccgcgctg
    14101 gccggggatc cgcgctacag ccggcggatg ctcacccaag cgcggcgcta cctggcgggt
    14161 gagctgcacg aactctgcct ggactggccg gagtagggcg gtagagcggt ccgatgttgt
    14221 tgtgtgccgg gggcccggcc cggcccatgg cggcaggtgg gccacgggcg ccttcgggac
    14281 ccggccacga gtagaactag ccggggacgg ccgggcctag gacgcgggcc agggcggtgc
    14341 gggaggagac gcccaacttg cggtaggcgc tgcccagatg ggagtcgacc gtgcggtggc
    14401 tgaggaagag gcgctcggcg atctgccggg agcgcagtcc cgcggcggcc agatcggcga
    14461 cctcccgctc gcgctcgctc agcgcggacc agaggtccgc gacccgggag cccgcgctcg
    14521 gatgggggct cagggccggc cgagtgtcgg cggagaggcg ggctcggacg cgttcggctt
    14581 cctccacggc cagggccgcc ccgcaggccc gggccatgga ctcggcccgg gccagaacgt
    14641 ccagtgcggc gcccggaccg cgtaccagcg cggtcgccgg tgccgaggcg atgagcgtcc
    14701 acgcgtgctg cacgggcagg cctccaccac ggaaggcctc cgccgcccgc tcgaacagct
    14761 ccagcgcccc ggcgtgctcc ccgcgcgccg accgcagctg ggcgccggcc cggtggacgc
    14821 acgcccactg caacggcaga ccgagccggc cggcgtccgc ctccgcgtcg gcgagcaacc
    14881 gctcggcgcc cacggcgtca ccgccggcca gcgcggcggt cgccatcagg gcgaggagcg
    14941 agggccggaa ggcgggctgc acctgcggca ggccatcacc gccgccgccg tcccgcagcg
    15001 tccgcaggca gccggtggcg tccccgccga gcagctgtgc gtgcgccagc aggctgatcg
    15061 cggaagtggc ccaccagccc cggccgagag ctacgacgtc caccgcccgc gccgcgagcg
    15121 cgaccgcctc gcccgcgtac cgccgccccc gggcccagac cagcgtcatg gcgcgcatcg
    15181 ccgtcgccag cgtcaccacg tcgggcgcgc cgaccgcgcg ggccagctct cccgcctcga
    15241 cggcccggcg ctccgccccg tcgagccggc cggcccactg gtcgatcatg gtcaggccca
    15301 gcagctggtg ggcgcggatg tgcttctgcg ccccgccggt cgcggcatcc agaccccgct
    15361 ggaggtggcg gcgggcgtcc gggaaccgct ccaggtacag ctccgcgcag ccgaggaggg
    15421 cgaggacgtc cggggtgtgg ccggccaccc cgtccggcaa cgcgtccacc agagcggcgc
    15481 agcgggtcac ttcgggcgct ccccgcgcga tgtcgccgga gaacacgtcg cagaaggcga
    15541 tgaggacgcc cagggccgcc gaggcggagg gcccggcctc ggtccgcgcc cgggcggcct
    15601 cccgcagcag cggccggatc cggtcgtggg tgccgcgcag gacgtgcacc agcccgtact
    15661 cgtagatcag ctcggtggcc tcgggggaca gtacggcggg cagcggccgg ggcagcagcg
    15721 ccatcccggt gcgggcgatg gcctccgcct cctcgtagcg gcacagcagc cgctccgcgt
    15781 cggcgcagac cgcgtacgcc cgcagcagca gccgcggggt cagccgagcg cccccgtcgt
    15841 cggcccgccc ggcgggccgg gggtcagcag gccgggaacc gccctcggcg agcaggtcat
    15901 gggcgagggc gcgggcctcc cggatgtgtc cggaggcgat gagcgcccgg cagtgcgcga
    15961 gctcccaggc cgcccgctcc tcgacctccc ggccacgggc gggcagcgcg tccagggcga
    16021 gccgcagcca gcgggccgcg atcgcgggtg cccgggtgac cgtctccgcg gccccttcgg
    16081 cgaggacgcg agccgcggcg gccccatcgg tgtgcactaa gtgctccgcg tgccgggccc
    16141 gctccacggc cggggcgccc cgctcggcgg ccatccgcaa ggcccgccgg tgggcgtcca
    16201 gcaggaaggg aagctcgcag tcggcgtggg cgacctgccc gacgaccgga tgacggaacg
    16261 ccagccgctg gccgtggccc gccggacgca ccagatccgc gcggaccagc tccgcgcacg
    16321 ccgccaggcc gtcccgcgcg ccgagcccgg cgatccgggc ggcgtccgcg ggccggaacg
    16381 tcccgcccag cacggccgcc gcccgcgcgg cggcccgcgc cggtccgctc agcgcgccga
    16441 gctcggcgag cagcggcgcc gcctcccgca gcagacggtc ctcgtccccg cccgcccggt
    16501 ccggccacag cccggcatcg aagccggccg cgaccagcag ccgcaggtac cccggaagtc
    16561 ccttcgacgc ggtgtgcagg accgccgcgg aggcccccgt cctgctcggg agtgcatacg
    16621 cgggggccgt ggccgcatcc ggcgctccgg ccccgtacgc ccccaccgcg agcggtcggc
    16681 gccagcggtc gagcagggcc gccaccgccg ccacgtccag cgggccggcc tccacccgga
    16741 cgatcccagc cgtccgtacg cccaggtcaa gcgcctccaa cagggccggc ggactttgcc
    16801 ggggccggtg cgccagaacc agcacgaagg gggaggggga aggagcggag gacgagaggg
    16861 agcggatcag ccggagcgcc agctccagcg aggacggatc ggcccggtgc atctcgtcga
    16921 ccaacagcac gccaccggcg gcccgctgcc ggatcagctc gtaccaggcg gccgggtcgg
    16981 ccgggtcgga cccctcggcc agcccggtcc gccccgcggc gtcgcggaag acccggaacg
    17041 ggccctcgcc cgcgcggggc gcgcgggccc agatcaccgg aagcccgcgc cgcccggcct
    17101 gctccgccag ccagcaggcc aactgcgttt tgccggaacc cggttcaccg gcgatctcga
    17161 ccacggcccc ccggccgcgc tccaatccgt ccaggacctg cgagagccgc gcgctctgcg
    17221 cctcacgtcc caccggcgga ccgtccgcca tcggtgacgg cacaacgaac atcacccctc
    17281 ccccctgcgg ccgctgctcg atccaggcat tgccaaggca atgccaaggc aatgccaagg
    17341 caatgcaagg cgaggccgca cgtcagtctc ggaaacctct ccccccgctc ctcactttgt
    17401 agcgcgccgc actgacaacg acccggcgcc gccgacggct cacttcaccg acggcgtcct
    17461 gcgctacgta tccggttgcg tagttctacg gctgtgcggg gccgggccac cgggaagact
    17521 gccgtcccgt cagctcatca ccccgacctg ggagaacccg tgaagttgag atccattgcg
    17581 gcgacggccg tactcggcgc cgtcgtcttc accgccgttc cggccgctgc cgtccccttc
    17641 agcgcctacg cctgcggtgg ctccaccctc tgccaggacg aggacccggg cgacgagggc
    17701 ggcggcgatg aaggcggcgg cggtggcaac tggggcggcg gcgactgggg cggcgaagga
    17761 ggcagtggcg agggaggcga cggcggcggc gactggagca acgacccggg cgaccccggg
    17821 aacgtcccct ccgatccggg gggctcgggg gtggagatcg tggacgggcc gatcggccag
    17881 cccatcgacg cgaccctgcc cgaggtcgtg gtcaccgggc acgccacccg tccctccgcc
    17941 ccggccagcc ccggcatccc gacgacccac gggggcggcg tcagcggccc cggccccctg
    18001 gtcaccgtgc acagccgggg cagggtgtgg gaggagcgcg ggaagtgcta ccgcaaccag
    18061 tccggctccg tcgaggccaa gtacagccag ggagtgacct acacggtcgc cacccagacc
    18121 agcaccaaca tctcggcgac ggcgctccag atgctcaccg cccagatagg tacgcagctc
    18181 aacaccaccg tgaccgagac ctacaacacc gagctcacgc tcaagccggg tgagtcctgg
    18241 gccgtttacg tcgagtacca gaccaatgtc tacgcgatca ccacgtccga cttctggggc
    18301 aactactcga ccgagttcgt caacgtcaca cagcccaccg gcgtcgtggc gggtcgcgcc
    18361 tgctaggtcc tgatgtcaca tgtcccgccc acctcagcag tgacgcgagg gagacggctg
    18421 ctgggtggag cgggggcggt ggaagggcct gtcgtggggg ccgtcgggcg gtcacgcgcc
    18481 gtccggcggc caggtgtcgc ggtcgcggcg gtggtggaac tccgtcagtt ccgaggcgag
    18541 gacgtcgaag tgcgggagcg gggcccacag gccgcgctcg ccgatgacgt agaggcggcg
    18601 tttggcccgg ctcgcggcga cgttgagcag gtgcggggtg cgggccgccc agtcgcgggc
    18661 gccgggccga ccgccgccga gcacgaggac gacgacgtcg gcttccttgc cctgggcccg
    18721 gtggacggtg gcgcagcgct cctcgatcag ttcggacgtc cagccgtcac ggccgcggca
    18781 gatcttctgg cattcggcga cgagggcccg gaagggggcg atgacgcgca cgcgctcgac
    18841 gccgacgccc tgccggcgca ggtggtcgag gacgaactcg aaggcccggc ggtcgcgttc
    18901 gccccacggc gcgtcggacg ggcgggacgg gtcgtcggtg gccagccagc ggctgggcag
    18961 caggccgtcc cgttccgcat cggggaacgc cttgtgtgcg gtgccgtgga ccatgaggcc
    19021 gccgtacgcg acctcgttgc tgaccgtgaa catcggctcc tcgcaacggc ggtgcacgcg
    19081 cagcggcgag cccacccaaa cgtgctcgtc gccggtgtcc ggggccggca ggtaggtgcc
    19141 gtagcggttg gtccggtcgg cgacggcctg ggccgaggtg gccgacggca gccagtgctc
    19201 gtcgacgccg taggcgcgca gcagtcggcg ctggagggcc ccgggcatgg tgacgacggg
    19261 ttcgagctgg agcggatcgc cgaccagaac ggccctgcgg gcccgccaca gcgcgccggc
    19321 ggcggcctgc ggggtggcct gcccggcctc gtcgacgagg acccagccga tggactcccg
    19381 gccgaggcgg gcgaacatgc tccccacgga ggagaaggtg gtcgagacga cgggcaccag
    19441 gaggaacagg gtctgccagg cgtgcgcgac ctcctcgtcg gggacggccc cgttggtccc
    19501 ggccatcagc tccatgagga cctggaggtt gccgcggacc ttcttcgcgg ccccggcgac
    19561 gaaggcccgg tgcaggtcga gggcgcgcag gaacaggtcg ctgcgcgcgg tggaccacgc
    19621 ctcgtcggac cagggcgagc cgagttcctg gtcggcttcg ccgaggtggg cccagccgag
    19681 cggcagggac ggcagcgtcc gggccgcctc ccgcagttcg cggtggtggc cgtcgagttc
    19741 ggcgacggcg ccccgcaggt cgcggcggga cgagtcggcg ctctgccggg cctgccgcag
    19801 ggaggcggct gccgaggact cccgcgcgct cgcggcccgt tcgccggcgc gggcggcggt
    19861 gaggccgtcg gccgcctcgt cgaccgcgcc gccggaccgg gcgtgccggc cggcggccag
    19921 ggattcggcg cgcacggctg aggcgacctg ctccagggac tcttcgagcg cggcgcgctg
    19981 ctggacgagc aggtgcgcga gctcggcctg ggtgtgctcc tgctgccgtt cggcggcctg
    20041 ccggtcggcc gcgctctgca gcagccggcg cagcccgccg cgcaggcccc gctcgacggc
    20101 cgggggcgtg tcgtggcggg cggtgagcgc ggtgacgtac tcgcggtggt gcgcggccag
    20161 ttcacgcgcg gccgagaggt ccgcgcgggc ggtggccagc tcctggcggg cccgcggtac
    20221 gtatgcggag gccgcccggt gtccggcctc ggccgccgcg gtggccgtcc gggcggcggc
    20281 ggtggcggcc gcggcccggt ccaggaccgc ggcggcggcg gtgacctgcc ggtcggcccg
    20341 ggacacggcg gcctccaggt ccgcgatccg ctgcccggcc gacggggact cgacggccgc
    20401 cagggccccg gccagccggg tgcgcccggc gcgcagccgc tcgacctcgt cccgggcggt
    20461 acggaacgcg gcgacggctt cggtccacga cggcacgggc cgggcgggcc cggccgccgc
    20521 ggtcgcgccc cggtccgccg gggcggcggg accacggcca ccggtctgag gcttgggcgg
    20581 gatccagtcg ctcaggacct cccgcatgcc gcgcagcggc ggcagctccg cggccttgcg
    20641 ggcgtcgctc tccttctgcg gcagccggcc ccaccagaac cggtccccga actccttgcg
    20701 gttggccttg ttgccgagca ccgccgcgac cagaccccag gccggcccgc cgaggagcgc
    20761 ggaggcgagg tcggagaagt ggtcggggcc gttgtgccag tgctcgccga gcgcaccgat
    20821 gccgggcagc tcggcggtga tgttctccac ggcgccgttg ttggaggagg tgaccacgat
    20881 ctcgaacccg gtcagccggg ggtcgagccg cgacacgaac cgggggtgcc cgccctggcg
    20941 gtccctgccc cgccacaccg ggccggtgaa cgcctgcgcg ggccggtcga gcgtggccag
    21001 caccgccgcc cgctcgacga ccagggcggc gaccaggtcg cgcagcatcg tggtcttgcc
    21061 cgtgcccggc gggccgttca cggagaacat cccgccctcg gttcccgccc gtccggcgag
    21121 catgcggtcg accgcgaact gctggctcag cgcgagcggg aaccgcgccg gtgcgggcca
    21181 gcggccggcc ggaaccaggt ccggggccac cccttccagg acgaccccgc gctcccggcg
    21241 cacatccgtc cgcgccccca cgtcgacggc gtcgagctcg gtcaggtacg cctccagcgc
    21301 cgggccgatc cccttcccga cggccgcgga cacccgggcc agatcagggg ggagcaggct
    21361 gttcaggaac ggcgcggcgg cggcgacctt cgtctgcggg tcccgcggcc ggtggaccag
    21421 cctgctccgc acccggacca cccgcggccg caggtgctcc tgaaccccgc acaggtcggc
    21481 gatctgcgcg gtcagagcca ccagatcggc gaaccccagc gcacggggac cggccccggc
    21541 cccggccccg gccccggact gtgccgacgt gtcaggaccg acggccgccg cctcgggaac
    21601 gctcccggcg cggaccggcc gcccggcctc cacctgctcc tcggcgtggc gccgcgccgc
    21661 gacccagtcc gcggcgcggc gcaccagggg ttccgccgcg ccctgcaacg cggcgccggc
    21721 gacctcgccg aacagggccc cgaccgcgcc gacggcggcg ccgcccagga tctcggcgag
    21781 cagcgactgc cagcccccgc cgcccgccgc tcccggcgct cccgccgcac cctcggagcc
    21841 gggcgaccgc tcgtacgccg ttccggcggc cggtggggtg gggccgtagg ggatcgcggt
    21901 ggcggtgaga tcgtcgatcg ccccgccgaa cgcgtcgtcg agctcctcga atccgtccag
    21961 ccacccgggt gtggacggcc ccggatcgaa gaggcggccg gtcgcccagg cgcacgccga
    22021 gatcacggac gtgtcttcga gcggtcggcc ctcgtcgtcc aggaccagcg cgaacatcgc
    22081 gctctggccc gacagcacca gctcgctctg cggcacgccg gggtcgggat cggttcccgc
    22141 gggcagtacc gcgatcatcg cctggcggag cgactccagg tcgaagaccc cgcagtagac
    22201 ctcgtgccgc cacatacggc cgtacggtgc cctccgggcc cccgtctgag gatggtcggg
    22261 agcccacggc aggagcggcg gtacccggcc cggctccggc gccaggtcgg ttacgtactc
    22321 gtccctcggc ccggagcggg cggcggggcg ccggcggggt agcgccggga tggtcggcgg
    22381 gctgaacagc tcgatcgcgc gccagcactc cagcagggcc tgccgtcgac gctcctgtgc
    22441 gtgtccgttc cgcacccact gcccccgtgt cgcccgcgcg gcatgctgcc gctcccctga
    22501 agatcagccg tacagccgaa tctaccggac cgtcagcagg ccgtgccccg gcggcggctc
    22561 agctctcggg gcggagcagg ccgcgctcgt acgccttcac caggcgctgc ggcacctggt
    22621 acacggagcc gtcgaccgtg accgggacca gctgcggcgc ggtggccttc cactgggccc
    22681 ggcggtggcg ggtgttgctg cgggacgtct tcctcttggg gacggccatg gggtcctccg
    22741 taagttgtta ggtggcccgg gagggccgga tgtggcttat ggggtcttgt cttcagtggc
    22801 ttcccaggag tggccgtccg gctctccggg gcgccctggc tgctgattga gatgtgcgcg
    22861 cttcgtgcgg tcgctgattg cggagatgac agcggggtgt tcctcgggcc gacggctgtt
    22921 ggtgcggaac gaggaggggc gaatgaggga gcggaaggcc cgggtctgga ccggtatcga
    22981 tgccggtaaa ggccaccact gggcggctgt ggtcgatgag accggggcaa cgctgtggtc
    23041 gaggaaggtc gataacgacg aggcggcgat cttgaccgca ctcggtgaaa tcctcgacct
    23101 ggcggacgag gtccgttggg cggtggacat ctccggcaca tcgtccgcgc tgctgcttgc
    23161 cctgctcgcg gctcacggcc agcgggccgt ctacgtgccc ggccgcacgg tcaaccgcat
    23221 gtcgggtgcc taccggggcg aggcgaagac cgatgcccgc gacgcctacg tcatcgccga
    23281 gaccgcccgc caccgcaacg acttcgccgc catcgacgtg cccgcccaac tcgccgccga
    23341 cctcgccctc ctgactggcc accgctcgga cctggtggcc gaccgcacga ggatgatcaa
    23401 ccgactgcgc gacgtactga ccgggatctt ccccgccctg gagcgtgcct tcgactacag
    23461 ctcgcagaag ggcgcactgg tcttgttgac gggctgccag accccgggcg caatccgccg
    23521 ccgcggccgg gcacgcctca cggcctggct ggccaaccgc agcgtgcgaa gtgcggacag
    23581 cgtcgccgcg accgcattga gggcggcccg ggcccagcag gctgcgctgc ccggtgagga
    23641 gatcgccgca cagatcgtgg ccgacctggc tggacagatc ctggccctgg acgaccggct
    23701 gaagcggatc gacaagcaga tccgcgagac gttctgcagc catccgcaag ccgagatcat
    23761 cgagtccatg cccggcatgg gcccgacact cggcgccgag ttcgtcgtcg ccgccggcga
    23821 cctgtccgca tacgtcgatg caggccatct ggcctcggcg gcagggctcg tgcccgtgcc
    23881 gcgtgactcc ggccgccgga ccggcaacct ccaccggccc aagcgttaca gccgccgtct
    23941 gcgacgggtg ttctacctgt ccgcgcagac cagcatcatc cgcgacgggc cgaaccggga
    24001 cttctacctc aagaagcgcg gcgagggctg caaacacgtc caggccgtca tcgctctcgc
    24061 ccgtcgacgg gccagcgttc tgtgggcgct gctgcgtgac ggacgagtct tcacctccgc
    24121 tccgccggtc acgcaggcgg cttgacttcg tcattgagac tcctgggtga gtcgggttgt
    24181 tgccggggtc tatcgggtgc cgtacgggag cagggccatc tcccgggcgg tcttgacggc
    24241 ggcggcgagc tcgcgctgct gccgggccgt gacgcgggtg acgcggcggc tgcggatctt
    24301 gccgcggtcg gagacgaact tcctcagcag gtcggtgtcc ttgtagtcga tggaggtgat
    24361 ccccgccgtg tccagcgggt tggggcggga cctgagcggc ttgtgggggt tctggcggcg
    24421 ggccatgcgt gttcctttcg ggggttgggt gtacgggctt acgagacggg gtcgagcagc
    24481 gagtcgaagg cggcgggaag gcacttccac gcctcgggtc ccgccgcgta ttcggcgtcg
    24541 gtgaggaggc aggactcgag gagttgctcc aggccgggcc ggtcgaggcc gggggaggtg
    24601 aagacgaggt gctggcagca gtcgccgtgg tcggggtgcc agtcgagcga ggccgccgcc
    24661 cgccgcatcg gcgggaccag ctcccaggcg gcgtccggca gtgacgcgag ccaggggccg
    24721 gtgttctcca cgcacagggc gccgcccgcg gagtcccagg cgagcagggt gtcggggcgg
    24781 tccgcgagcc agaagcggcc gcggctgcgg gcggcggcgc agcagaggtc ctccagcgcc
    24841 tcgtagaggc gttcggggtg gaaggggcgg cggcggtgcc agaccagggt ggtcactccg
    24901 gcctcgtccg cctcctgggg gaggagggcg caggccgggt gctgggcggc ggccgcggcc
    24961 tccacgtcga acccggcgag ggccagcgcg gccagctcgc cgctgtcggc ggccacccgg
    25021 cgggcggtcg gatggagctg ggcgagcagg gcacggtcct cggcgccggc ctccccgctg
    25081 tcgacgaggg cgagcacggg cgcgtattcg agctgccgcg cccaggtgtc cccgacggtg
    25141 cgctgatcgg tggcggcggc cgcgaggccc gcgtcggcca ggtcgtcgcc gttgacgagg
    25201 tacggcagga cgagcgccgg gtccaccgcg gtgatcacgc cggtgagttc gagcgcgcgg
    25261 gcgccgtgcg cggcgacgac ctcggccatc gccttgggct cgacggagtc ccacagttcg
    25321 acgacggcca gccgggtcag gccgctgccg gccagccgtt ccagctcggg gacgaggtcc
    25381 tcgcgcagtg cgcagcaggc gcagtcgttg acgaggggcg tctcgccccg ggacagctcg
    25441 cccgaggcgt cgcgcaccac gcgcaggacc gtgccctgcg ctgccgtggc caggtcgtgg
    25501 tggagggcga tgctgccggg gacggtgtgc agcaggcgct ccacgacttc cttgcgggcg
    25561 tccgcatgga gcccgccgac gatgacgacg ggcagggtca cgacgtgctc ccgtaccggc
    25621 gctggaagcg ctcgacgcgg ccggcggtgt ccaggacgcg ggcggtgccg gtgtagaagg
    25681 ggtggctccg cgaggagatc tccacgtcga tgacggggta ggtgttgccg tcctcccact
    25741 ccaccgtctt gtcgctggtg gcggtcgagc gggtgaggaa ggcgaagtcg gcggccttgt
    25801 cgcggaagac gacggggccg taggcggggt ggattccggg cttcatgtcg gtgtccttcg
    25861 gggcggggga ggggcggggg ccggtcagcg ctcttcgcgg aagtcgacgt gccggcgcac
    25921 caccgggtcg aacttgcgca ggaccaggcg gtccgggtcg ttccgccggt tcttgcgggt
    25981 gacgtacgtg tagccggtcc ccgccgtgga gcggagtttg acgacgggac gtatctcgtt
    26041 gcgtgccatg ccgctactat acgggaatgg aaatcgtttc caataaccac ttccgtccag
    26101 agaggggcag gtagcacttt gtccgcccac tgccagctga ccggcgcccg gccgggcttc
    26161 ggcaacaaca tctcccactc gcaccggcgt acctcccgcc gcttcgaccc caacatccag
    26221 agcaagcgct actggctgcc gggcgagggg cgccacgtgc gcctgaccct gagcgccaag
    26281 gcggtcaaga ccatcgacgt catcggcatc gaggccgcgg tggcccggat ccgcgcccgg
    26341 ggggtgaagg tctgatggcc aggaagagca agatcgcgca gaacgagaag cgcaaggcga
    26401 cggtcgagcg gtacgccgcg cggcgcgccg agctgaagga ggtcctgcgg cggccgtccg
    26461 ccacggcggc cgagcggcgc gcggcgctgg cggagctgcg cgggcagccc cgcgacgcga
    26521 gcgccacccg ggtgcgcaac cgggacagcg tggacggccg gccccgcgga cacctgcgga
    26581 agttcgggct ctcgcgcgtc cggatgcgtg agcaggcgca tgccgggttc ctgcccggag
    26641 tgaccaagtc ctcctggtag cagccgtatc ccggacggtc gtccgcacag gtgtggcccg
    26701 gcacctcctc gtcgtccgag gaggtgccgg gcctgtgtca cggtctcagg agacggtgac
    26761 gaagacgctg tgccagccgc tcgcgccgtc ggggacggtc cgggcgcgct cttcggtctg
    26821 cacccggccg gcgccgtcgg tggcgcggac ggtgagcgtg tgcccgccgg gggtggcgtt
    26881 ccagcggtac gaccacgggc gccaggtgtc gacggtgtcc tgtacggcga ggtcggcgtc
    26941 ctgccaccgg ccgtcgtcga cgcgcacctc gacgcgggtg atgccgcggc gctgggccca
    27001 ggcgacgccg ccgacggtga cggcgccggc ggcgggacgc gcgaagggct tcggggtgtc
    27061 gatccgcgcc tgggtcttga tcggtgcgcg gcgggcccag ctgcgcttga cccagtaggg
    27121 gtcgtaggcg tcgaaggtgg tgagttcgag gtcggtgatc cacttgcagg ccgatacgta
    27181 gccgtacagg ccggggacga gcatgcggac gggaaagccg tggtcga
//
