LOCUS       NZ_BMVE01000002        25857 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000002
VERSION     NZ_BMVE01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1126124)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 850932
            Orig. end                         :: 876789
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25857
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="lanthipeptide-class-ii"
                     /region_number="6"
                     /rules="(micKC and not PKS_KS)"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..25857
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iii"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22622
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22622
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12622](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12622)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    962..976
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(1023..1038)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     misc_feature    1262..1277
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            1508..8605
                     /locus_tag="IE248_RS09035"
                     /old_locus_tag="GCM10010336_18320"
     CDS             1508..8605
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566667.1"
                     /locus_tag="IE248_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18320"
                     /product="ricin-type beta-trefoil lectin domain protein"
                     /protein_id="WP_190030353.1"
                     /transl_table=11
                     /translation="MPSQAFAAPPSGSRAGVDLIDLQKEPVARDAGTGALDELTGEATQ
                     PVDAYVPEKIDAPAGGQGTAPLTTPAAGQLVKADQLPVLIGPPKDATAAEAAALAGNWQ
                     VALAQPEQTAAAEVDGMLLTVTPPAGASGEVEVSLDYSEFKELYSADWANRLQFVQYPR
                     CFLQSPDNEACNEAVRLNSDNNDDSDRISTTVDVASLTTPPTAPQSAASFTTGGSIVDG
                     VYRTSRKAEALRTLMPAVDGGATGGVFATVDSGSGAKGDYTATPLVSAGTWSAGSNSGA
                     FNYTYQLTAPPAPAGPAPSIAFQYNSQVVDGRTSATNNQASWLGDGWEYNPGSIERTYR
                     GCSDDTAGGANNASHKTGDLCWGSWNAVLSLGGSTTELVRDDTSGQWVTKNGDGSKIQL
                     IKDSAKPKANGDDDDERWIVTTRDGTQYHFGLNRLPGWADGKSTTDSVLTVPVSGNQPG
                     EPCYNSDFSKSFCDQAWRWNLDYVVDVDGNAMSLWWKKETNFYSKNEKYTTPVKYDRGG
                     YLLNIDYGQRSDTLFSAPPVDRVSFGVGERCREEGALKCTDAAFASRDYERYRIWYDTP
                     AHLYCSGTVGKRCPVPSPTFWSRKQLSSVTTQAQRTKGSTALQNVDTWNLTQSFPRTLT
                     DGSPPLWLESVKRTGYGTDGKSLPLNPVEFSHNNAPMPNRVVKGPDDHRPAFDRLRIRR
                     VMTEYGGEIDVQYSTPAGSCASGTGQPTPEANKALCYPVFWSPDPDQETTDWFNKYVVE
                     SVEERPRIDGVPDLVTDYVYVGDAAWAKNDTEFSKRKTRTYDQWHGYAQVDVFKGRPDA
                     TDGSVQSKSSSRFFRGMPGQTVLDSKGATIAADHPAFQGMTAESISYTQAVGGEVSSRS
                     ISYPKAIPLASRARGDGLDALTAYRVENGKSTTITPSSGTGDDKRTSRTATITTEYDSV
                     YGLPEKVESQGDTGVTGDETCTVSEYLHNTAAHLIGLVKQVRTTVGSCAQAATASVVTA
                     SRTAYDGGAYGAAPTRGLATTEWSNDAAGTGWIRSSVLTHDSYGRVRSVEDAAGRTATS
                     SYDPPTGQVYATTSTNAAGKTSTGTVDPGRSTGLTVKDVNGKVTAYAYDALGRATGMWA
                     PSQNPATDPPAKSFSYYTKVGKPVSVTTSVLRDDDTRAESTTFYDGLGRVRQSRKNAVG
                     GGWMVSDTYYNEAGQIRRTDNGYLAEKVPADELFEKKSDFQVPNSTVTTYDGQGQPLTV
                     TPLYAGVAQTARKTTYAYGWDYTTVTPPTGAAKTRTWTDALGRAVRVDHYNSTAPGGLT
                     STRYGFDVRGNRVSAKDAKNNEWSWKFDARGRQIEATDPDTGTRSQTYDDLDQPVLSTN
                     SRGIKVWTGYDVLGRVTGQRLNDANGEQLTAFGYDAVVGAVGQPSSATRYTGGAAYTST
                     ITGYDAEYRPTGKSITVPDTAATKGVAGTYNYGYTYTRSGLRKTTTVPAVGSLPQEKVV
                     TRYNQEGLPVSTSGTDWYTADTTYSPYGEVLRAVTGEQPYRVWTTNVFDEGSGWATQMV
                     TDRETADAHRVNERAFRYDNAGNITLTADKYPSSDAANATVTTDRQCFIYDGLGQLTEA
                     WTSPHTECKAPGQTTRQPVYKDATGAVVATNVTDANEGYWHSYSYDVIGNRTKLVEHDA
                     TPTVTAGQVDTAGDTTKSYSYGIDPSGSGVPKQPHTLTGLSTDTPTVDTTASMGYDSAG
                     NTTTRTYGGEGAQTLTWTWDGKPEKVTGTGKDGFTQVNGLAGKCLDLSNGDPTTGSPIQ
                     LFQCNGTKAQQFRLDGDGTAPGGKTGALKVRDNCVMPTGGGTGSGTTITVAPCTGAANQ
                     KWTTAANDGLKHVASGLCMDVPGGNEANSTDVILYNCNGGANQSWKFEDTTSYVYDADG
                     SRLIASTAGTNTLYLPESEYRTSTTGMLVYCQRYYSQAGAPTVVRNSELNWGASSLTAI
                     ISDQHGTPVAGVDLGSGQNVQRMRTEPFGTERSSSAAFRSHRGYVGGGDDNSTGLTHLG
                     ARLYDSTTGRFVSADPVIDLGDPLQMNGYAYSANNPVTLSDPSGLMPNPKGGCPVCFNP
                     PSTTTPAPTPPPSTSSTTTQTVSVTVTKTVTVRKPPKDCNWWCKTKGWLREHKEVVSFV
                     VEITVSGACFGAAIAGAVETAGATLVAAAGCGALGAAAGASVNNALTPEADHSTLGILK
                     DQAKALAPGAASGVVGLGVGKVLERGAGAIASKLLSTKPAASGAGSAASGKAAGGTPAR
                     ASTLADDGSATSGGATRTNAAYRGDNETVFHGHGSYTEANGTVTVPKGTSIAFYGPHGK
                     TITRQMGMLVSGPGGPARQPLEVFDEGAVIPNYTLAPLGPGFTFRDGATVVEQRTLLSD
                     LLKEGMGRTHWAACRSCRR"
     cand_cluster    2831..25857
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    2831..25857
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12830:15857](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12831..15857
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
     gene            8707..9345
                     /locus_tag="IE248_RS09040"
                     /old_locus_tag="GCM10010336_18330"
     CDS             8707..9345
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS09040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_18330"
                     /product="hypothetical protein"
                     /protein_id="WP_190030354.1"
                     /transl_table=11
                     /translation="MEYVDLSRYVYSTSLVPMQNLGWLGTSAGIQGGSEPPVTPVEAKA
                     LERASKWLSAVTLGVHECEFCPPGRTHSGNGEFHYYSAGGDTYAAPALINHYVRDHGYR
                     PPLIFRAAALSECPLVWDRRADFLAAALADDTVDFELRCEAVVDIAYWADRRSLEMLER
                     AACDAEISDIAGREIGISLRRVLQGMPGSMLSISLDRLAPDVRAGLVDE"
     CDS             9652..9867
                     /gene="allorf_0860584_0860799"
                     /locus_tag="allorf_0860584_0860799"
                     /protein_id="allorf_0860584_0860799"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGGVQIQPPCDQNADGVRPGGSPGQTPLCCRYGEGSMADLRHGER
                     PMGVPACYIGSGKMSLMLQATLKQGK"
     CDS_motif       9652..9714
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGGVQIQPPCDQNADGVRPGG"
                     /locus_tag="allorf_0860584_0860799_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9715..9867
                     /prepeptide="core"
                     /locus_tag="allorf_0860584_0860799_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="5205.1"
                     /monoisotopic_mass="5201.6"
                     /core_sequence="SPGQTPLCCRYGEGSMADLRHGERPMGVPACYIGSGKMSLMLQ
                     ATLKQGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGGVQIQPPCDQNADGVRPGG"
                     /leader_location="[9651:9714](+)"
                     /alternative_weights="5223.1"
                     /alternative_weights="5241.1"
                     /alternative_weights="5259.1"
     CDS             9680..9835
                     /gene="allorf_0860612_0860767"
                     /locus_tag="allorf_0860612_0860767"
                     /protein_id="allorf_0860612_0860767"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTKMPMASDPGVVQVRRHFAAVTAKGAWQISVTVRDPWGYPLVTS
                     APGRCR"
     CDS_motif       9680..9760
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTKMPMASDPGVVQVRRHFAAVTAKGA"
                     /locus_tag="allorf_0860612_0860767_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9761..9835
                     /prepeptide="core"
                     /locus_tag="allorf_0860612_0860767_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.30"
                     /molecular_weight="2673.0"
                     /monoisotopic_mass="2671.4"
                     /core_sequence="WQISVTVRDPWGYPLVTSAPGRCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKMPMASDPGVVQVRRHFAAVTAKGA"
                     /leader_location="[9679:9760](+)"
                     /alternative_weights="2691.1"
                     /alternative_weights="2709.1"
                     /alternative_weights="2727.1"
     CDS             9804..9980
                     /gene="allorf_0860736_0860912"
                     /locus_tag="allorf_0860736_0860912"
                     /protein_id="allorf_0860736_0860912"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLHRLREDVADAPGDAEAGEIGLRLGVQCLEREDLAHGCPPLSSR
                     GGVGRSLRTWARG"
     CDS_motif       9804..9917
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLHRLREDVADAPGDAEAGEIGLRLGVQCLEREDLAHG"
                     /locus_tag="allorf_0860736_0860912_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9918..9980
                     /prepeptide="core"
                     /locus_tag="allorf_0860736_0860912_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.00"
                     /molecular_weight="2041.3"
                     /monoisotopic_mass="2040.1"
                     /core_sequence="CPPLSSRGGVGRSLRTWARG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLHRLREDVADAPGDAEAGEIGLRLGVQCLEREDLAHG"
                     /leader_location="[9803:9917](+)"
                     /alternative_weights="2059.3"
                     /alternative_weights="2077.4"
                     /alternative_weights="2095.4"
     gene            complement(10001..12622)
                     /gene="lanKC"
                     /locus_tag="IE248_RS09045"
                     /old_locus_tag="GCM10010336_18340"
     CDS             complement(10001..12622)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="IE248_RS09045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18340"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_190030355.1"
                     /sec_met_domain="micKC (E-value: 5.2e-145, bitscore: 480.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.7e-14, bitscore:
                     47.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEGFGEALADREYYLPLPSVADPGPRFAPGEVPPGLSGAAQGIW
                     TVWGGPRTGFAEQGWKIHVSARLDRAQHVLDTVAGICFSEGVPFKHLSARLFFLFLHHK
                     HAGRAQAGKFCAVYPPDTATARRLLERLRDALDGEEGPYVLSDRRYRDSRTVHYRYGSF
                     GGRGRLRADGTREGLVRDGSGREVVDLRLPAFHLPAGIVDPFVEQEEQPHAGPILIRDY
                     EVTRAVRLSNAGGAYQARDRRTGRPVFVKEARAHNGLVFDGTDAQQRLRHEHRVLRELH
                     AAAPGVGPEPLDHFTEWEHEFLVTEYVAGQPLVGWLSRSSPLAHADRTAESVEAYYEAC
                     RRLLAELDASLERLHAAGYRFGDLSLGNVVVTPSGGVRLVDFEAASALDAAPSGMGTPG
                     FTPPPGLLRTDTDPLLRDRYGMSALALSFLAPFNEIAEHAPANLALLRRDLADLAPPQD
                     LWQRATAFHPTQDQARDQDGPGRLPSPAELDADPRGCLTRLAEEVAGGLLETADADRPE
                     WAFPPSPEAFRTNNVCLAYGTAGVVHALHSAGARVPEEILERLRRDALAQRGSLPPGLL
                     VGSAGIARVLAGLGRLEEAVDLLRDADEHPLTASCDTLAGGRAGVGLAWLALHRLTGES
                     GHLERAAAAGEHLLRAPGRPAALGDHDARGLLHGRSGVALFLHRLARETGETRCLEGGR
                     LLLHQELDRTFPLDDGALSLSDDARFTRAMPYLATGAAGLAAVLTRYVATAPDERCAAA
                     LPRLVAGIRVSRATKEAGLYRGLAGLSWFLTGHAELTGTDAAREDAVRAATGLLKYAVP
                     YRRGVRFLGAGSQRFTADLSSGGAGVLLALHRLLAGPLLTEPHDAGLRIPAAARRRRAG
                     VP"
     gene            12831..15857
                     /locus_tag="IE248_RS09050"
                     /old_locus_tag="GCM10010336_18350"
     CDS             12831..15857
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488914.1"
                     /locus_tag="IE248_RS09050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18350"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_229895190.1"
                     /sec_met_domain="DUF4135 (E-value: 1.9e-108, bitscore:
                     358.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.8e-26, bitscore:
                     86.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAGQGRAGGSLSAVERWWAAGLVGDGGAEGRPDWAAFAEEASAA
                     APEEAVAPEGDHPGLSGFEWVLRPFTVCAGERLERVLSERARGLVEMTAVRDDLERYLG
                     GRLARTAARTLVLELYEARSAGRLDGEDTRARFRDFLGRVASRRGLTALLAGRPVLARI
                     LGRAALDAADAVAEALERLADDHARLTAGLLAESGGDPGLLVAVAPGAGDGHRGGRSVM
                     LLRFADGTRLVYKPRSLSVHRHFNDLVAWFNELPDSVHLRTLRLLDRGDYGWVEFVGAA
                     PCASATEIETFYRRQGALLALLHLIDGTDLHHENLIAVGADPVLIDVETLFHPPLTGTA
                     TEDPAAGALHDSVYRVGLLPQLLVGDHSALDVSAVGGGREAVSPVVRADWADAGTDRMR
                     LVRRAGRFGESANRPRLADGGPIEPAAHIEALCAGFRAGYKAIGAAREELLHETALLKE
                     FAEDEVRVVVRPTWVYSTLLDESTHPDLLKDAGERQRVLETLRTDVLGTVLAPDLVDEE
                     IAQLWAGDVPLFTARPGRDHLWGAAERPLAGRADLSGIARVAARLAALDAVDRQDQEWI
                     VRAAMATASRAPAHRPVGDRRTRTAERAPEPERLLSAARSVGDRLVSLAYREGPRSNWI
                     GLELLDDRYWRIGPMPADLAGGYTGPALFLAQLAALTGAGHYAEVARTALAPVPGLLDA
                     LRARPADLGAVGSGAFSGLGGIAYALAETARLLDDPEIGSWASAAHRLAGAAALSEREY
                     GVGAGVAGGLVALLAAHRAGGGDEAQETWRDARACADRLTAVDPTAGGRGFTTGAAGLG
                     WALLRFAEAEASAGPGGAAAEGSERYRLAGLSALRAAVDGEPDGGRGPGGHGGAPTDDG
                     PADEARASAWCGGHAGIALAVLDAPGALEDPYLAAWSRRTVEELGRDRPAADDSLCHGE
                     AGLCELLGHTAVPEARPHWIRRAGALLASVEETGARSGAPDGVPHPGLLTGLAGIGHGL
                     LRAGFPERVPSLLLLQTSC"
     misc_feature    complement(12858..12873)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.61"
                     /tool="antismash"
     CDS             complement(15926..16024)
                     /gene="allorf_0866858_0866956"
                     /locus_tag="allorf_0866858_0866956"
                     /protein_id="allorf_0866858_0866956"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGRSGGRAEPCGGAGGSVCRVVRSCGREVVRS"
     CDS_motif       complement(15986..16024)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGRSGGRAEPCGG"
                     /locus_tag="allorf_0866858_0866956_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15926..15985)
                     /prepeptide="core"
                     /locus_tag="allorf_0866858_0866956_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="1923.2"
                     /monoisotopic_mass="1922.0"
                     /core_sequence="AGGSVCRVVRSCGREVVRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGRSGGRAEPCGG"
                     /leader_location="[15985:16024](-)"
                     /alternative_weights="1941.2"
     gene            16039..16245
                     /locus_tag="IE248_RS09055"
                     /old_locus_tag="GCM10010336_18360"
     CDS             16039..16245
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262709.1"
                     /locus_tag="IE248_RS09055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18360"
                     /product="hypothetical protein"
                     /protein_id="WP_190030356.1"
                     /transl_table=11
                     /translation="MTTQINDSVRYVDSSAGAETAAHDHPVGEVTFGASGMLGLRSRLL
                     RTADSDAAATVDTPWTTGSLTLF"
     gene            16367..19330
                     /locus_tag="IE248_RS09060"
                     /old_locus_tag="GCM10010336_18370"
     CDS             16367..19330
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508338.1"
                     /locus_tag="IE248_RS09060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18370"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190030357.1"
                     /transl_table=11
                     /translation="MRATSSVIVGRDAEIRLLDEALESVTRGAGRAVFLVGEAGIGKSR
                     LAGESTLRAYDRDMPVLRGRATSTGLVVPFRPLVEALSSRFRAAGAPDDPELQPYRPAL
                     AGLVPEWRAEAVAPGYAISLVELAEALLRLLAVLGRERGCVILLEDLHDSDTETIAVVE
                     YVVDNVAELPVLLVGTLRPDPGPALDLALAAELRNTASLRELGPLDETAVRDMAAACLD
                     VGPGEVPPAAGRHLAQWAGGNPYLVEVLLADLLDTGRLSRAEGGWQLAEHDEATVPTGA
                     VRSWARRLARLDEPVRELLLVAATLGGRFSVGALRAVTGLDDRALFAHLRTASEVGIIA
                     PDGAAHDHYTFRHALTADALRASLPPAEQAALARRAASAIEESAVELCGDQKQLVAALR
                     LAAGDKAAASRQFAEVGRQMLDAGASGSAAMLLERARGLAADEDRDEVTVQLAIAQAEC
                     GRLDEAAALLDDLPPAPAGSRAAEERAQAHTQVAWVATMAEQPAQAHRRIRAARALLGA
                     DPRPEQEAALAVVEGHLALLPEQDGRGEGRGPVGWGGEDGRERLEEAERSARRAALTAE
                     QRGRPVVACQAWQLLAMLSRERGFDEADACLERMLAVAEEHRLAVYRAEALVRLGTNAF
                     MRTGEATRLETARTAAHELGSLALLQSVDGLLAMQSVLGGRWERARGIVERSVEASARL
                     QNLSTHRYLLLVDATLAAHQGRAREQERALLRFRRAGGQESMLVPLQRGLCQAVGALMG
                     EDRERAKAELDAALAWEREHPSFFYLSGRYGLGPLLRILDGEDGGREAHREALASPGGQ
                     LAWNRMFLGMADAVLRGRDGDPDGARRAVERAGRAAAVFPQAWHLALRLTAEAALADSW
                     GEPVAWLRSAEEYFHEAGVSPVAGACRAALRQAGVSVPQRRGGRERIPAGLRTAGVTPR
                     EYEVFVLLAQRPGNQQIAQSLCISPRTVEKHMASLMTKTGSADRSALCALSAESADS"
     misc_feature    19408..19420
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            19527..21329
                     /locus_tag="IE248_RS09065"
                     /old_locus_tag="GCM10010336_18380"
     CDS             19527..21329
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511312.1"
                     /locus_tag="IE248_RS09065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18380"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_190030358.1"
                     /transl_table=11
                     /translation="MPRPFAKPAASPSPLRYRVLGPLAVHRDDRALPLGPLKQRVVLAT
                     LLGSANSPVSVDVLTDAVWQEEPPRTARKNLQVYVSALRALLADDELDRPRLIHTGGGY
                     MLRVAEDELDLLRFRSLVRAAEGQGPRPAARLLRQALDLWQGPPLGDDLRLSPRLAEEA
                     ERLELRHLTAYEGWAEAELELGGAPAVVEGLRDLVERHPLRERLRSAWMRALSGSGRQA
                     EALAAYDDYRQLLARELGLEPGGAMAARYRMILAGDDRAGTGAAARPPAAPPPDLPDFT
                     GHGEELRYLTDRLEDEGAGRIVLLSGPAGAGKTTLAVRAAHLLGDRFADGRLCVSLRDA
                     DGRTRSLPAVLAELGERTGQAGLSGPEAWREWLARHRVLVILDDVPDESAVRPLLPCGG
                     LGRVLLTARGQLGGLAPVDRVCVPPLGTAESVQLLAGLVGEGRVRADREAALRIVRACG
                     GSPLAVRVSGMRLAVLRHVPLREFADRLTDPAGALDELTSGDVSVRRWLAHGWEALPEE
                     WGRDAGRLAAGTGEGPFGLTEAAEALGCDERRAVRVVEALIDAGMVTSPCGEVTAHAAQ
                     YELPHLIRLYARGSGLGTPTPVLT"
     gene            complement(21398..23536)
                     /locus_tag="IE248_RS09070"
                     /old_locus_tag="GCM10010336_18390"
     CDS             complement(21398..23536)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262705.1"
                     /locus_tag="IE248_RS09070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18390"
                     /product="prolyl oligopeptidase family protein"
                     /protein_id="WP_229895191.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.4e-53, bitscore:
                     176.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPQTRRYPHAERQDVVEEAHGLRVPDPYRPLEDAESPATLRWSA
                     EQQTLYEAERASWADLEHWKAEVAAIDAVDRARSPEVRGGRVFWLRQDAGQEHPVLMVA
                     EAGADPTGRVLLDPSALDPSGRTVLDAWEPSVEGDLLAFQVSRNGTEDSLLQVLDVATG
                     RIVDGPVDRVRRSSIGWLPGGEAFYYVRNLDPSPHPGEGRYHRRVCLHRVGTDPETDAL
                     VFGEGRDKTQFYSVSVTADGRWLGVTATLGTGRGTDLYLADLSAGPLERPELRPVQEGM
                     DAATRLYAVPGTGPRDLVWLRTDRDAARGRVVACRPAELALGPAAWREVIPERPDAVLT
                     HLVVLSGPELKHPLGLAAWTRDTVAEVTVHDLVEGRQVATVPLPGTGAVGDFSAGPPGG
                     HEAYFAYTDFVTPPRILRFDARTGRASRWERDAPDAPGVGGAVTRQIAFPSRDGTTVRM
                     FVISPTGRPDVARPALLTGYGGFGRTMSPRYRAQVLAWVRAGGVFAWAGLRGGGEEGEA
                     WHRAGSGRNKQNTFDDFAAAGDHLIAEGWTEPGRLAIMGGSNGGLLVGAALTQQPEKYA
                     AVVCVAPLLDMVRYELSGLGPSWTPEYGSAQDPALLPTLLGYSPYHRVTPGTAYPAVLL
                     VAADGDTRTDPLHARKMCAALQHASSGTGPVLLRLERGVGHGDRSASRAVALQAECLAF
                     LAGQVGLPPPGRTAPASP"
     gene            complement(23548..25026)
                     /locus_tag="IE248_RS09075"
                     /old_locus_tag="GCM10010336_18400"
     CDS             complement(23548..25026)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378574.1"
                     /locus_tag="IE248_RS09075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_18400"
                     /product="MFS transporter"
                     /protein_id="WP_190030360.1"
                     /transl_table=11
                     /translation="MTPRLTLINRDYTRLWFGQAVSSVGDAVFSTTLVLWVATVLAKGE
                     SWAPLAVSGIVMASGVAVLVIGPLAGVFVDRWDKRATMLRSEVLRGVLVAVLTVITFLP
                     AGALPAGVWLALIYVTVLLLHAAGQFFSPARFAVLADLVTGDADRARAAGIAQATGETA
                     WIIGPPLAAPLLFTVGLQWALLFNGLSYAVSYIAIRSIGARELGTGSARPAAERGPVER
                     QQGALRKEFMDGLRFFAGSRFLVALLLLAVIGQFGAGALGTLNVFFATDNLHADAHLYG
                     YLGMAMGAGGITGALCGGRMVQWLGARRTTWIGLLVSGVLLVAYSRQTGFLGGVALLFA
                     FAVPLTMLNTAMSPLLLAAAPPDYRGRVMAVFYPVTRLASMLSAALSGWLAGSVLRDVG
                     GSLGGLRFGPVDTIIAASGLIVLLAGVFAMAALPDTGAGKPAARAGEDTAAPADQADPA
                     AKERQDAEVVAHHDDGELSARATDRSDDPRPTDG"
     misc_feature    complement(25001..25014)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
ORIGIN
        1 gccgaggccg ggcagggcga ggacgtcggc gggggtccgg ggggcgccgg agccggcggg
       61 tgtcgcggcg tcgccgaccg tggccgggtc ggccttgccc gcggagtccc acatgaacgg
      121 ggtgggcgag gaggcgacct ccttgccctg acggtccgcg gcgctcaggc tcttggtgac
      181 cgggtcgagg ctgaagacga ggtcgggcga gctcaatccg tacgagaggc tcgccagggc
      241 ggggctcgcg gcggcttcgg cgttcttgac caccaagacg tgggagaagc cggcatcgcg
      301 cgcggtcagc aacaggtcga ctccgggcag cacttccggg tacagggcgc gagggccctc
      361 gatgatgggc agcggaaccg gtccgggcca ggacagggtc agccggtgac cgccggtttc
      421 gagggtggcg agcggggtcg tgcccgcccc ggccgcgtcg agaggggccc gctggacgga
      481 ccgggaagag cgcccggccg tgccggccga gaagaccgcg gggttgttga cggccttcgg
      541 cgcccagccg tcatcggtgc gggtcagcgt ggtgtcgatc tccttccact caccgccgac
      601 cttggcccgt accgggcggg tgtgcgcggt cagctcgaag ctgccgtccg gcatggccat
      661 ggtgctgttg gtcgcggtgc gcagctccgt gacctccacg ggcttgccgg tagaccgggc
      721 cttgtcctgc gcctcgtcgt ggtccagcag gccgttcgcc cgcggggccc ggttcggggc
      781 atcgtgggac gggccgtcag cgggcagcgc cagcagcccg gccgccagcg cggcggtgat
      841 gcccagggcg gcgagtcccg ccgttttgcg attcggcctg cggccgggcc ggagcctttt
      901 cacggtctgt ctttccctcc caggcggact tccgcaggtc cattcggtct gttcacgtaa
      961 tggatcatgc ggtccgcgcg ggcagatcat gacgcatggg cgcgcacgct ccaattcgaa
     1021 gtgtgatcgg aacgtgacgt aggtgggaaa tttgaggcgc gcggaactcc gggcgggcct
     1081 cctgcgtctc tcctggtgag ctgtaccgat ggctgagatg agttgggtga accgcatcaa
     1141 atcggtgagt ccggacaaac ggcatgctgt tctggctgga tttgatccct tgcgatatga
     1201 cctatcgcat tcgccggatg aatgcccgaa gctgcgcact cgcgatgaat cggtaggtcc
     1261 gatacccgtg ggcgttatat ctcgtgatcg agatctcagt gaaatgcatt gatttgacgg
     1321 ccgcattccc ccgcctcaat gatgcgcgga caattgatct ttcgggcctg gggggctctg
     1381 cgtgttctca tcgttgtcgt ggtccgggag gggctccttg ccccggacca cgagtggccg
     1441 gcgtcgtgca cgccggaacc ggctggccgt cggtacggcc acggccgccg cactactggt
     1501 caccctggtg cccagtcagg ctttcgccgc accgccgtcc ggctcccggg ccggtgtcga
     1561 cctgatcgac ctccaaaagg agcccgtcgc gcgggacgcc ggaaccggcg ccctggacga
     1621 gctcaccggc gaggcgaccc agccggtcga cgcctacgtt ccggagaaga tcgacgcgcc
     1681 ggcgggcggc cagggcacgg cgccgctcac cacaccggcc gccggtcagc tcgtgaaggc
     1741 cgaccagcta ccggtgctca tcggcccgcc caaggacgcc accgcggccg aggccgccgc
     1801 gctcgcaggt aactggcagg tcgcactcgc ccagcccgag cagaccgcgg ctgccgaggt
     1861 ggacggcatg ctgctcaccg tcaccccgcc cgcgggcgcc agtggtgagg tggaagtcag
     1921 cctggactac agcgagttca aggagctgta cagcgccgac tgggcgaacc gcctgcagtt
     1981 cgtccagtac ccgcgctgct tcctgcagag cccggacaac gaggcctgca acgaggccgt
     2041 caggctgaac tcggacaaca acgacgacag cgaccggatc agcacgaccg tcgacgtcgc
     2101 cagcctcacc acgccgccca cggcaccgca gagcgccgcc tcgttcacga cgggcggctc
     2161 gatcgtggac ggcgtgtacc ggacctcccg caaggccgag gcgctccgca ccctgatgcc
     2221 ggccgtcgac ggcggtgcca ctggcggcgt gttcgccacc gtggactccg gctccggagc
     2281 caagggcgac tacaccgcga ccccgctggt cagtgccggc acctggtcgg ccggcagcaa
     2341 ctcaggtgcg ttcaactaca cgtaccagct gaccgcaccg ccggctcccg ccggaccggc
     2401 cccgtccatc gccttccagt acaactcgca ggtcgtcgac ggtcgtacct cggccaccaa
     2461 caaccaggcc tcctggctgg gcgacggctg ggagtacaac cccggctcga tcgagcgcac
     2521 ctaccgcggc tgcagcgacg acaccgccgg cggcgccaac aacgcctccc acaagacagg
     2581 cgacctctgc tggggctcgt ggaacgccgt gctcagcctc ggcggcagca ccaccgagct
     2641 ggtccgcgac gacacgtccg gccagtgggt cacgaagaac ggtgacggct ccaagatcca
     2701 gctgatcaag gacagtgcca agcccaaggc gaacggcgac gacgacgacg agcgctggat
     2761 cgtcacgacg cgggacggca cccagtacca cttcggcctg aaccgcctgc ccggctgggc
     2821 cgacggcaag agcaccaccg actccgtcct caccgtcccg gtctccggta accagcccgg
     2881 cgagccctgc tacaacagcg acttctccaa gtccttctgc gaccaggcat ggcgctggaa
     2941 cctcgactac gtcgtcgacg tcgacggcaa cgccatgtcg ctgtggtgga agaaggaaac
     3001 gaacttctac tccaagaacg agaagtacac caccccggtc aagtacgacc gtggcggcta
     3061 cctgctcaac atcgactacg gccagcgctc cgacaccctc ttcagcgcgc ctcccgtgga
     3121 ccgggtcagc ttcggcgtcg gcgagcgctg ccgcgaggaa ggtgcgctca agtgcaccga
     3181 cgcggcgttc gcctcgcgcg actacgagcg gtaccggatc tggtacgaca ccccggcgca
     3241 cctgtactgc tccggtaccg tgggcaagcg ctgcccggtc ccctcgccga ccttctggtc
     3301 gcgcaagcag ctgtcctccg tcaccacgca ggcgcagcgc accaaaggct cgacggcgct
     3361 ccagaacgtc gacacctgga acctgacgca gtcgttcccg cgcacgctga ccgacggctc
     3421 ccctccgctg tggctggaat ccgtcaagcg gaccggatac ggcaccgacg gcaagtcgct
     3481 gcccctcaac ccggtcgagt tctcgcacaa caacgccccg atgcccaacc gtgtggtgaa
     3541 ggggccggac gaccaccgtc cggccttcga ccgcctgcgt atccgccgcg tcatgacgga
     3601 gtacggcggc gagatcgacg tccagtactc cacacccgcc ggctcctgcg cctcgggcac
     3661 cggacagccg actcccgagg ccaacaaggc cctgtgctac cccgtcttct ggagtccgga
     3721 cccggaccag gagaccaccg actggttcaa caagtacgtc gtcgaatccg tcgaggagcg
     3781 cccccgcatc gacggggtgc ccgacctcgt caccgactac gtgtacgtcg gagacgcggc
     3841 ttgggcgaag aacgacaccg agttctccaa gcgcaagacc cgcacctacg accagtggca
     3901 cggctacgcc caggtcgacg tgttcaaggg acggccggac gcgaccgacg gatcggtgca
     3961 gagcaagtcc tcgtcccgct tcttccgcgg tatgccgggg cagaccgtcc tggactccaa
     4021 gggcgccacg atcgcagccg accaccccgc cttccagggc atgacggccg agtcgatcag
     4081 ctatacgcag gcggtcggag gtgaggtctc ctcccgctcg atcagctacc cgaaggcgat
     4141 cccactcgcc agccgggcgc gcggtgacgg cctcgacgcg ctgacggcct accgcgtcga
     4201 gaacggcaag agcacgacga tcaccccgtc gagcggaacc ggcgacgaca agcgcacctc
     4261 gcgcacagcc accatcacca ccgagtacga cagcgtctac ggccttccgg agaaggtcga
     4321 gtcgcagggc gacaccggcg tcaccggcga tgagacctgc accgtctccg agtacctgca
     4381 caacacggcc gcccacctga tcggcctggt caagcaggtc cgcaccaccg tcggcagctg
     4441 cgcgcaggcg gccacggcct ccgtggtcac cgcgagccgc accgcctacg acggcggggc
     4501 gtacggcgcc gcgccgacgc gcggcctggc caccaccgag tggtccaacg acgcagcggg
     4561 taccggctgg atccgcagct cggtcctcac gcacgactcc tacggtcggg tcaggtccgt
     4621 cgaggacgcg gccggacgga ccgccaccag cagttacgac ccgcccaccg gccaggtcta
     4681 cgcgaccacg tccaccaacg ccgcgggcaa gacctcgacc ggcaccgtcg accccggccg
     4741 ctccaccggc ctgaccgtca aggacgtcaa cggcaaggtc accgcctacg cctacgacgc
     4801 cctcggccgg gccacgggca tgtgggcgcc cagccagaac ccggcgaccg acccgccggc
     4861 gaagtccttc tcctactaca ccaaggtggg caagccggtc tccgtcacca cctcggtact
     4921 ccgggacgac gacaccaggg ccgagagcac cacgttctac gacggcctcg gccgcgtgcg
     4981 gcagtcccgt aagaacgccg tcggcggcgg ctggatggtc tccgacacct actacaacga
     5041 agcgggccag atccgccgga ccgacaacgg ttacctcgcc gagaaggtgc cggcggacga
     5101 gctcttcgag aagaagagcg acttccaggt ccccaactcg acggtcacca cctacgacgg
     5161 ccagggccag ccgctcaccg tcaccccgct gtacgcgggc gtcgcgcaga ccgcgcgcaa
     5221 gaccacgtac gcctacggct gggactacac cacggtgacc ccgccgacgg gtgcggccaa
     5281 gacccgtacc tggaccgacg cgctcggccg cgccgtacgg gtcgaccact acaactccac
     5341 ggcgccgggc gggctcacct ccacccggta cggcttcgac gtgcgcggca accgcgtgtc
     5401 ggcgaaggac gccaagaaca acgagtggtc gtggaagttc gacgcccgtg gacgccagat
     5461 cgaggcgacg gacccggaca ccgggacccg ctcccagacg tacgacgatc tggaccagcc
     5521 cgtcctgagc acgaattccc gcggcatcaa ggtctggacg ggctacgacg tcctcggccg
     5581 ggtgaccggg cagcgtctga acgacgcgaa cggcgagcag ctgacggcat tcggctacga
     5641 cgctgtcgtg ggtgccgtcg ggcagccgtc ctccgcgacc cggtacacgg gcggagcggc
     5701 ctacacctcg acgatcaccg gctacgacgc cgagtaccgg ccgaccggca agtccatcac
     5761 cgtcccggac acggccgcca ccaagggcgt cgccggtacg tacaactacg ggtacaccta
     5821 cacccgcagc ggtctgcgca agacgaccac cgtcccggcg gtgggcagcc tgccgcagga
     5881 gaaggtggtc acccggtaca accaggaggg cttgccggta tccacgtccg gcaccgactg
     5941 gtacaccgcc gacaccacct acagcccgta cggcgaggtg ctgcgcgcgg tcaccggtga
     6001 gcagccgtac cgcgtctgga cgacgaacgt cttcgacgag ggcagcggct gggccaccca
     6061 gatggtcacc gaccgcgaga cggctgatgc gcaccgggtc aacgagcggg ccttccgcta
     6121 cgacaacgcc ggcaacatca cgctgacggc ggacaagtac ccgtcctccg acgcggccaa
     6181 cgccacggtc acgaccgacc gacagtgctt catctacgac ggcctcggcc agctgaccga
     6241 ggcctggacc tcgccccaca ccgagtgcaa ggccccgggc cagacgaccc ggcagccggt
     6301 gtacaaggac gcgaccggcg cggtggtggc gaccaacgtc accgacgcga acgagggcta
     6361 ctggcactcg tactcgtacg acgtgatcgg caaccgcacc aagctcgtcg agcacgatgc
     6421 cacgccgacg gtcacagcag gacaggtcga caccgccggg gacaccacga agtcgtactc
     6481 gtacggaatc gaccccagcg ggtcgggagt ccccaagcag ccgcacacgc tgaccggact
     6541 ctccacggac accccgaccg tcgacacgac ggcctcgatg ggctatgact ccgccggcaa
     6601 cacgaccacc cgcacctacg gtggagaggg cgcccagacc ctcacctgga cctgggacgg
     6661 caagcccgag aaggtcacgg gtaccggcaa ggacggtttc acccaggtca acggcctggc
     6721 gggcaagtgc ctggacctga gcaacggcga tcccaccacc ggctcgccca tccagctctt
     6781 ccagtgcaac ggcaccaagg cgcagcagtt caggctcgac ggtgacggca ccgccccggg
     6841 tggcaagacc ggcgcgctga aggtccgtga caactgtgtg atgccgacgg gcggcggcac
     6901 cggatcgggt acgacgatca ccgtcgcgcc ctgcaccgga gcggccaacc agaagtggac
     6961 gaccgctgcg aacgacggcc tcaagcacgt cgcctccggc ctgtgcatgg acgtgcccgg
     7021 cggcaacgag gccaacagca ccgacgtcat cctctacaac tgcaacggcg gagccaacca
     7081 gtcctggaag ttcgaggaca ccacctcgta cgtctacgac gcggacggca gccgcctgat
     7141 cgcgagcacg gccggtacga acacgctgta cctgcccgag tcggagtacc gcaccagcac
     7201 cacgggcatg ctcgtgtact gccagcggta ctacagccag gcgggcgctc cgaccgtggt
     7261 gcgcaactcc gagctgaact ggggagcgtc gagcctcacg gccatcatct ccgaccagca
     7321 cggcaccccc gtggcgggcg tggacctggg atccggccag aacgtgcagc ggatgcgaac
     7381 ggagccgttc ggaaccgagc gaagcagctc ggccgcgttc cgctcgcacc gcgggtacgt
     7441 gggcggcggc gacgacaaca gcacgggact cacccacctg ggcgcccgcc tgtacgactc
     7501 caccacgggc cgcttcgtct cggccgaccc ggtcatcgat ctcggcgacc cgctgcagat
     7561 gaacgggtac gcgtactccg ccaacaaccc ggtgacgctc agcgacccct cgggcctgat
     7621 gcccaacccg aagggcggct gcccggtctg cttcaacccg ccgtccacca ccacacccgc
     7681 gccgaccccg ccgccgagca cgtcgagcac gaccacccag accgtgtcgg tcacggtgac
     7741 caagacggtc acggtgagga agccgcccaa ggactgcaac tggtggtgca agaccaaggg
     7801 atggctccgc gagcacaagg aggtcgtgag cttcgtcgtc gaaatcaccg tcagcggtgc
     7861 gtgcttcggc gcggcgatcg ccggtgctgt cgagacggcg ggtgcaaccc tggtcgccgc
     7921 ggcgggctgc ggcgccttgg gcgcggcggc cggtgcctca gtgaacaacg cgctgacacc
     7981 ggaggcggac cacagcacgc tcggcatcct caaggaccag gccaaggccc tggcccccgg
     8041 cgcggcaagc ggcgtggtgg gcctaggcgt cggcaaggtc ctggagcggg gcgccggcgc
     8101 gatcgccagc aaactgctgt cgaccaagcc ggctgcgagc ggcgccggat ccgcggcttc
     8161 cggcaaggcg gccgggggga cgcccgcgag ggcgagcact ctcgccgacg atggttctgc
     8221 cacctcgggc ggtgcgacgc gtactaatgc ggcatatcgc ggggacaacg aaacggtgtt
     8281 ccacgggcat ggcagctaca ccgaagcgaa cggcaccgtc accgtcccca aggggacctc
     8341 gattgccttc tacggtcccc atggcaagac catcacccgg caaatgggca tgctggtttc
     8401 aggtcctggt gggcccgcta ggcaaccgct cgaagtcttc gatgaaggtg ctgtgattcc
     8461 gaattacacc ctggcccctc tcgggcccgg atttaccttc cgtgacggtg ccacggtggt
     8521 ggagcagcgc acactgctga gcgatctgct caaggaagga atgggacgta ctcactgggc
     8581 cgcgtgccgg agctgccgcc ggtagaatgt ctgttctgaa ctgaccgctg tacgttgccg
     8641 gggcggctcg cctgctcaag gcgggccgcc ccggccgtct tctagctctt cgaccatcga
     8701 ggccctatgg aatatgtgga cctgtctcgc tatgtgtact cgacctcgct cgtgcccatg
     8761 cagaatttgg gatggctggg cacttccgcg ggaatccagg gaggttctga gcccccggtg
     8821 actccagtag aggcgaaggc gctcgagcgc gcatcgaagt ggctctccgc tgtgacccta
     8881 ggtgtgcatg aatgtgagtt ctgtccgcct ggccgcactc attccggcaa tggagagttt
     8941 cattattaca gtgccggcgg cgacacgtat gctgcccctg cgctgatcaa ccactacgtg
     9001 agggatcacg gatatcgacc tcccctgatc ttccgtgcgg ccgcactctc tgaatgtcct
     9061 ttggtgtggg atcggcgtgc agattttctt gcggcagcat tggcggacga cacagttgat
     9121 ttcgaactca ggtgtgaagc ggtcgtcgat attgcctact gggctgacag gcgttccctt
     9181 gaaatgctcg agcgggccgc ctgcgacgcg gaaatttctg atatcgcggg tagggaaatc
     9241 gggatctctc tgaggcgtgt tctgcagggt atgccaggaa gcatgctgtc catctctctg
     9301 gaccggcttg cgcctgatgt gcgagccggg ctggtagacg agtagggcgg ggatggccgt
     9361 ctggtagccg gtcaggcgcc tgcccacgac tcatgacgca ggtacggacc gggaggacaa
     9421 gggaacgcgg acgggcgggg ctgtagcgca gaggtcgacg cgcgcggttg cggttctcgt
     9481 gctcgacgga gtcaccgaag cagccgacgc ccgtcaaagc acccgggcca ccaagggaga
     9541 ctgctgcagg ggaacacgca tcgcctccat ccgccctagg cgcgcgggtt gatccgacca
     9601 tgctgtaggc cgacggcggg cacgtgctga ctgcggcgca gatcgcccgg attgggggga
     9661 gttcaaatcc agccgccgtg tgaccaaaat gccgatggcg tccgacccgg gggtagtcca
     9721 ggtcagacgc cactttgctg ccgttacggc gaagggagca tggcagatct ccgtcacggt
     9781 gagagaccca tgggggtacc cgcttgttac atcggctccg ggaagatgtc gctgatgctc
     9841 caggcgacgc tgaagcaggg gaaataggtc tccggctcgg tgtccagtgc ctggagcgcg
     9901 aggatctggc tcatggctgc cctccacttt cttctcgggg tggtgtcggt cggtcactgc
     9961 gtacctgggc acggggctga tcgccgccgt gaccaggcgt ttacgggacg cccgcccggc
    10021 gccgccgggc ggcggccggg atccggagac ccgcgtcgtg gggctccgtc aggagcgggc
    10081 cggccagcag gcggtgcagg gccagcagga cgccggcccc gccactggac aggtcggcgg
    10141 tgaagcgctg ggaacccgct ccgaggaagc ggacaccgcg ccggtacggg acggcgtact
    10201 tcagcaggcc ggtcgcggcg cgcacggcgt cctcgcgggc ggcgtccgtg ccggtgagct
    10261 cggcgtgccc ggtcaggaac cagctcagtc ccgccagccc ccggtacagg cccgcctcct
    10321 tcgtggcgcg ggagacccgg atgccggcga ccagcctcgg cagcgccgcg gcgcagcgct
    10381 cgtccggcgc ggtggccacg tagcgggtga gcaccgccgc gagaccggcc gcgcccgtgg
    10441 cgaggtacgg catggcgcgg gtgaaccgcg cgtcgtcgga gagggacagg gcgccgtcgt
    10501 ccagcgggaa ggtccggtcc agctcctggt ggagcagcag acggcccccc tccagacagc
    10561 gggtctcgcc ggtctcgcgg gccaggcggt ggaggaagag ggcgaccccc gagcggccgt
    10621 gcagcaggcc gcgggcgtcg tggtcgccga gggcggccgg ccggccgggg gcgcgcagca
    10681 ggtgctcccc ggccgcggcg gcccgctcca gatggccgct ctccccggtc agccggtgca
    10741 gggccagcca ggccaggccg accccggccc ggccgccggc cagcgtgtcg caggaggcgg
    10801 tgagcgggtg ctcgtcggcg tcccggagca ggtcgacggc ctcctccagc cggccgaggc
    10861 cggccagcac ccgggcgatg ccggccgagc cgacgagcag cccggggggc agcgagccgc
    10921 gctgcgccag cgcgtcgcgg cgcagccgtt cgaggatctc ctcaggtacc cgggccccgg
    10981 cgctgtgcag ggcgtgcacc accccggccg tgccgtacgc caggcacacg ttgttggtac
    11041 ggaacgcctc gggcgacggc gggaaggccc actccggccg gtcggcgtcg gccgtctcca
    11101 gcagcccccc ggccacctcc tcggccagcc gggtgaggca gccgcgcgga tcggcgtcca
    11161 gctcggcggg ggagggcagc cggccgggac cgtcctggtc ccgcgcctgg tcctgcgtcg
    11221 gatggaaggc ggtcgcccgc tgccacaggt cctgcggcgg agccaggtcc gccaggtcgc
    11281 ggcgcagcag tgcgaggttg gcgggcgcgt gctcggcgat ctcgttgaac ggcgccagga
    11341 aggagagcgc gagcgccgac atgccgtacc ggtcccgcag cagcggatcg gtgtcggtcc
    11401 ggagcaggcc cggcggcgga gtgaaccccg gggtgcccat cccggagggg gcggcgtcca
    11461 gcgccgaggc cgcctcgaag tccaccagcc ggaccccgcc cgacggcgtg accaccacat
    11521 tgcccaggct gaggtcaccg aaccggtagc cggcggcgtg cagccgctca agcgaggcgt
    11581 ccagctcggc cagcaggcgc cggcacgcct cgtagtacgc ctcgacggac tcggccgtac
    11641 ggtcggcgtg ggccagcggg gaggaccggc tcagccagcc caccaaaggc tgccccgcga
    11701 cgtactcggt gacgaggaac tcgtgctccc actccgtgaa gtggtccagt ggctccgggc
    11761 ccaccccggg cgcggccgcg tgcagttcgc gcagcacgcg gtgctcgtgc cgcagccgct
    11821 gctgcgcgtc ggtcccgtcg aagaccaggc cgttgtgggc gcgggcctcc ttcacgaaga
    11881 cggggcgccc ggtccgccgg tcccgggcct ggtaggcgcc gccggcgttg ctcaggcgca
    11941 ccgcgcgggt cacctcgtag tcgcggatca ggatcgggcc cgcgtgcggc tgctcctcct
    12001 gctcgacgaa ggggtcgacg atccccgcgg gcaggtggaa ggcgggcagc cgcaggtcca
    12061 cgacctcgcg gccggagccg tcgcggacca gcccctcccg ggtgccgtcg gcccgcagcc
    12121 ggccgcggcc accgaaggag ccgtagcggt agtggaccgt ccgcgagtcg cgatagcgcc
    12181 ggtcggagag gacgtacggc ccctcctccc cgtccagcgc gtcgcgcagg cgttccagca
    12241 gccggcgggc ggtcgccgtg tccggcgggt agacggcgca gaacttgccc gcctgggccc
    12301 gcccggcgtg cttgtgatgg aggaacagga agaagagccg ggcgctcagg tgtttgaacg
    12361 gcacgccttc ggagaagcag atcccggcga ccgtgtcgag cacgtgctgc gcccggtcca
    12421 gccgcgccga cacgtggatc ttccagccct gctcggcgaa cccggtccgc ggaccgcccc
    12481 acaccgtcca gatgccctgg gcggcgccgc tcaggcccgg cggcacctcg ccgggggcga
    12541 agcgcggccc ggggtcggcc acgctgggca gcggcaggta gtactcccgg tccgcgagcg
    12601 cttcgccgaa gccttcgagc acgggatctc ctcgcggggt ggtggtgggc ggcgacaacg
    12661 gtcttcgtgc cagacgctag gagcggcagg tatggaaacg gttcggcggc ggcatgcgac
    12721 cggtctggcg gggtggaaaa catgggggac tcttccccat gcgggggagg caccccccgt
    12781 accaggatcg ggcgtggcgc agagcggtgg gccgggggcg aggagcggtg atggtggctg
    12841 ggcaggggcg ggccgggggt tcgctgtcgg cggtcgagcg gtggtgggcg gccgggctcg
    12901 tcggcgacgg cggggctgaa gggcgcccgg actgggccgc gttcgccgaa gaggcgtcgg
    12961 ccgccgcgcc cgaggaggcc gtggcacccg agggggacca tccggggctg agcggtttcg
    13021 agtgggtact gcgcccgttc acggtctgcg cgggggagcg gctggagcgg gttctgtcgg
    13081 agcgggcccg cgggctcgtg gagatgaccg ccgtacggga cgacctggag aggtacctcg
    13141 gcggcaggct ggcacggaca gcggcgcgga ccctggtgct ggagctgtac gaggcgcgga
    13201 gcgccgggcg gctcgacggg gaggacacgc gggcccggtt ccgggacttc ctggggcgcg
    13261 tcgcgtcccg gcgcggtctg acggccctgc tggccggccg gccagtgctg gcgcggatcc
    13321 tggggcgggc ggcgctcgac gcggcggacg ccgtcgcgga ggcactggag cggctggcgg
    13381 acgaccacgc ccgtctgacc gccggtctcc tcgcggagtc cggcggggac ccggggctgc
    13441 tcgtggccgt cgcgccgggg gccggcgacg ggcaccgggg cggccggagc gtgatgctgc
    13501 tgcgcttcgc cgacggcacc cggctggtgt acaagccgcg ttccctctcc gtgcaccgcc
    13561 acttcaacga cctcgtcgcc tggttcaacg agctgcccga ctccgtgcac ctccgtacgc
    13621 tgcggctgct cgaccggggc gactacgggt gggtggagtt cgtcggcgcg gccccctgcg
    13681 cctccgcaac ggagatcgag acgttctacc gccgccaggg cgcgctgctg gcgctgctgc
    13741 acctgatcga cgggaccgac ctgcaccacg agaacctgat cgccgtcggc gccgacccgg
    13801 tgctgatcga cgtggagacc ctgttccacc cgccgctgac gggcaccgcc acggaggacc
    13861 ccgccgccgg agcgctccac gactcggtgt accgcgtcgg attgctgccc caactgctgg
    13921 tgggcgacca cagcgccctg gacgtgtccg cggtcggcgg cggccgcgaa gcggtgtcgc
    13981 ccgtcgtccg ggcggactgg gccgacgccg gcaccgaccg gatgcgcctg gtgcgcaggg
    14041 ccggaaggtt cggcgagtcc gccaaccggc cacgcctcgc cgacggcggg cccatcgagc
    14101 cggcggccca catcgaggcg ctctgcgccg gattccgcgc cgggtacaag gcgatcggcg
    14161 cggccagaga ggaactgttg cacgagacgg ccctgttgaa ggagttcgcc gaggacgagg
    14221 tgcgggtggt ggtacgtccc acctgggtgt acagcacgct gctcgacgag tcgacgcacc
    14281 ccgatctgct gaaggacgcg ggcgagcggc agcgggtcct ggagaccctg cggaccgacg
    14341 tgctcgggac ggtcctcgcg cccgacctgg tggacgagga gatcgcccag ctctgggcgg
    14401 gggacgtacc gctgttcacc gcccgtccgg gccgggacca cctgtggggc gcggcggagc
    14461 ggccactggc cggccgcgcg gacctctccg ggatcgcccg ggtcgccgcg aggctcgccg
    14521 ccctggacgc ggtcgaccgc caggaccagg agtggatcgt acgggccgcg atggcgacgg
    14581 cctcccgcgc tcccgcgcac cggcccgtcg gggaccggcg cacccgtacg gcggagcgcg
    14641 ccccggagcc ggagcggctg ctgtcggcgg cccggtccgt cggggaccgg ctggtctccc
    14701 tcgcctaccg cgaaggcccg cgcagcaact ggatcggtct ggagctcctg gacgaccgct
    14761 actggcggat cggcccgatg ccggccgacc tggccggcgg ttacaccgga ccggccctgt
    14821 tcctggccca gttggcggcg ctcaccgggg ccggacacta cgcggaggtg gcccgtacgg
    14881 ccctggcgcc ggtgcccggg ctgctcgacg cgctgcgcgc ccggcccgcg gacctcggtg
    14941 cggtgggctc gggggccttc tccggcctcg gcggcatcgc gtacgcgctc gccgagacgg
    15001 cacggctgct ggacgatccg gagatcggct cttgggcgtc cgccgcgcac cggctggcgg
    15061 gggcggcggc cctgtccgag agggagtacg gggtgggcgc gggcgtcgcg ggcgggctcg
    15121 tcgcactgct ggccgcccac cgggccggcg gcggggacga ggcgcaggag acctggcggg
    15181 acgcgcgggc ctgcgcggac cggttgaccg cggtggatcc cacggccggc ggccggggct
    15241 tcactacggg ggccgccggt ctcggatggg ccctgctgcg gttcgccgag gccgaggcca
    15301 gcgcagggcc cgggggcgcg gcggccgagg gcagcgagcg gtatcgactc gcgggcctgt
    15361 ccgcgctgcg ggcggccgtg gacggggagc cggacggcgg ccggggtccg gggggccacg
    15421 ggggagcccc tacggacgac gggcccgcgg acgaggccag ggcctcggcc tggtgcgggg
    15481 ggcacgccgg catcgccctc gcggtgctgg acgcgccggg cgccctggag gacccgtacc
    15541 tcgcggcctg gtcccgcagg accgtcgaag agctgggccg ggacaggccc gccgccgacg
    15601 acagcctctg ccacggcgag gccggactgt gcgaactcct gggccacacc gcggtcccgg
    15661 aggcacgccc gcactggatc cgccgggccg gagcccttct cgcctccgtc gaggagaccg
    15721 gtgcccgcag cggcgctccg gacggggtcc cgcatcccgg cctgctgacc gggctggcgg
    15781 ggatcgggca cggactcctc cgggccgggt tcccggagcg cgtgccctcc ctgctcctcc
    15841 ttcagacgtc ctgctagggg acggtccggc accacccacg gccgccgtcc gaggcgctcc
    15901 cgcacggagc ccccggcccc cgacctcacg acctcacgac ctcacgaccg cacgaccgca
    15961 cgacccgaca caccgaacca ccggcaccac cgcacggctc agcacggcct ccactcctgc
    16021 ccatacgaag gacggaccat gaccacgcag atcaacgact cggtgagata cgtcgacagc
    16081 agcgccggcg cggagaccgc ggcccacgac cacccggtgg gcgaggtgac gttcggggcg
    16141 agcggcatgc tggggctgcg cagccgactg ctccgaacgg ccgactccga cgccgccgcc
    16201 accgtggaca cgccgtggac caccggatcc ctcacgctgt tctgaggggg aggaggggca
    16261 cgtcgcgccg cgaggtgaca gggatgcgcc ccggacggat cgggcggagg ccggggggtt
    16321 ccccggccct ctgccgcgca cgaaaaagat caagtaacct gcgcgcatgc gagcgacgtc
    16381 gtcggtcatc gtggggcggg acgccgagat ccggctgctg gacgaggcac tggagagcgt
    16441 cacgaggggt gcgggacggg cggtgttcct cgtcggcgag gcggggatcg gcaagtcccg
    16501 gctggccggg gagtccaccc tgcgcgcgta cgaccgggac atgccggtgc tgcgcggccg
    16561 agccacgtcc accgggctcg tcgtgccctt ccggccgctg gtcgaggcgc tgtcctcgcg
    16621 gttccgggcg gcgggtgccc cggacgaccc ggaactgcag ccctaccggc ccgcgttggc
    16681 cggcctcgtg ccggaatggc gggccgaggc ggtggcgccc ggatacgcga tctcgctggt
    16741 cgaactggcc gaggcgctgc tccggctgct ggccgtgctc ggccgcgagc ggggctgcgt
    16801 gatcctgctg gaggacctgc acgactccga caccgagacg atcgcggtcg tcgaatacgt
    16861 cgtcgacaac gtggccgagc tgccggtcct cctggtcggc acgctccggc ccgatcccgg
    16921 cccggcgctg gacctcgcgc tcgccgccga gctgcgcaac accgcctcgc tcagggagct
    16981 ggggccgctg gacgagaccg ccgtacggga catggcggcc gcctgtctgg acgtcggacc
    17041 gggtgaggtg cccccggccg cggggcggca cctggcgcag tgggcgggcg ggaacccgta
    17101 cctggtggag gtgctcctgg ccgacctgct ggacaccgga cggctgagcc gggccgaggg
    17161 cgggtggcag ctcgcggagc acgacgaggc gacggtgccg acgggcgcgg tccgcagctg
    17221 ggcgcgccgg ctggcccggc tcgacgaacc ggtgcgggaa ctgctgctcg tcgcggcgac
    17281 gctcggcggc cggttctccg tcggggccct cagggcggtg accggactcg acgaccgggc
    17341 gctgttcgcc catctccgga cggcctccga ggtggggatc atcgccccgg acggggccgc
    17401 ccacgaccac tacaccttcc gtcacgccct gacggcggac gcgctcaggg cctcgctgcc
    17461 gcccgccgag caggccgcgc tggcccggcg cgcggcctcg gccatcgagg aatccgccgt
    17521 cgaactctgc ggtgaccaga agcagttggt ggccgccctg agactggcgg cgggcgacaa
    17581 ggcggcggcg tcgcgacagt tcgccgaggt cggccggcag atgctggacg ccggtgcctc
    17641 gggctcggcc gccatgctgc tggagcgtgc ccgggggctc gcggccgacg aggaccggga
    17701 cgaggtcacg gtgcagctgg cgatcgccca ggccgagtgc gggcgcctcg acgaggcggc
    17761 cgcgctgctc gacgaccttc cgccggcgcc cgccgggtcg cgtgccgccg aggaacgggc
    17821 ccaggcgcac acgcaggtcg catgggtcgc caccatggcg gagcagccgg cgcaggcgca
    17881 ccgccggatc cgggcggccc gcgccctgct cggggccgac ccgcgcccgg agcaggaggc
    17941 ggcgctcgcg gtggtcgagg gccatctcgc gctgctgccg gagcaggacg gccggggcga
    18001 ggggcgcggt ccggtgggct ggggcggaga ggacggccgc gagcgactgg aagaggcgga
    18061 acgttccgcc cggcgcgccg cgctcaccgc ggagcagcgc ggccggcccg tcgtggcctg
    18121 ccaggcgtgg cagctgctgg ccatgctgtc ccgggagcgc gggttcgacg aggccgacgc
    18181 ctgcctggaa cggatgctgg cggtcgccga ggagcaccgg ctcgcggtgt accgggccga
    18241 ggcgctggtg cggctcggta ccaacgcctt catgcggacc ggtgaggcga cccgcctgga
    18301 gaccgcccgt acggcggctc acgaactcgg ttcgctggcc ctgctccagt ccgtcgacgg
    18361 gctgctcgcc atgcagagcg tgctgggcgg gcgatgggag cgggcgcggg ggatcgtcga
    18421 gcggtcggtg gaggccagcg cccgcctcca gaacctgtcg acgcaccgct atctgctcct
    18481 cgtcgacgcc acgctcgccg cccaccaggg gcgggcccgc gagcaggaac gcgccctgct
    18541 ccgcttccgc cgggcgggcg gccaggagtc catgctcgtg cccctgcagc gcggactgtg
    18601 ccaggccgtg ggcgcgctga tgggagagga ccgggagcgg gcgaaggccg agctcgacgc
    18661 ggcgctggcg tgggagcggg agcacccgag cttcttctac ctcagcggcc gctacgggct
    18721 cggccccctc ttgcggatcc tcgacggcga ggacggcggc cgggaggcgc accgggaggc
    18781 gctggcctcg ccgggcggac agctggcctg gaaccggatg ttcctcggca tggcggacgc
    18841 ggtgctgcgc ggccgggacg gcgacccgga cggcgcgcgg cgcgccgtgg agcgggccgg
    18901 ccgtgcggcg gcggtgttcc cgcaggcatg gcacctcgcc ctgcggctga ccgccgaggc
    18961 ggccctcgcc gactcctggg gcgagccggt cgcctggctg cgcagcgccg aggagtactt
    19021 ccacgaggcg ggagtgtcgc cggtggccgg ggcctgccgc gccgcgctgc ggcaggcggg
    19081 ggtcagcgtc ccgcagcgcc ggggcggccg ggagcggatc cccgcgggcc tgcggaccgc
    19141 gggcgtcacg ccgcgcgagt acgaggtgtt cgtgctgctc gcgcagcggc ccggcaacca
    19201 gcagatcgcc cagagcctgt gcatctcgcc ccgaacggtg gagaagcaca tggcgagcct
    19261 gatgaccaag accggctccg cggaccgctc ggcgctgtgc gccctgtccg cggagtccgc
    19321 ggattcctag ggcccgtcgt tcggatcatg ccgggctggc gggccgggat gggggacgct
    19381 cccgccttta tgggggtgcg gtcccccatg acgcggtcac ggacggcgcg actctgcggg
    19441 cccggcaccg atgtgtgacg ggtacgggcc ggaggaccat cgaggggtac ggccaactcc
    19501 cccgtcaccc tacggaggtt cgctcgatgc cgcgtccgtt cgcgaagccc gcagcgtcac
    19561 ccagcccgct caggtaccgc gtcctcggcc cgctcgcggt ccaccgggac gaccgggccc
    19621 tgcccctcgg cccgttgaag cagcgggtcg tgctggccac actgctcggc tccgccaaca
    19681 gcccggtctc cgtcgacgtg ctgaccgacg cggtctggca ggaggagccc ccgcgcaccg
    19741 cccgcaagaa cctccaggtg tacgtgagcg ccctgcgcgc gctcctcgcg gacgacgagc
    19801 tggaccggcc gcggctcatc cacacgggcg gcggatacat gctgcgcgtg gcggaggacg
    19861 agctcgacct cctgcggttc cgctccctgg tgcgggccgc cgaggggcag gggccccgcc
    19921 cggccgcccg actgctgcgc caggcactcg acttgtggca gggaccgccg ctgggagacg
    19981 acctccggct gtcgccccgg ctggccgagg aggccgagcg gctggagctg cgccacctca
    20041 cggcctacga gggctgggcg gaggcggagc tggagctggg cggcgcgccg gccgtggtcg
    20101 aggggctgcg ggacctggtg gagcggcacc cgctccggga gcggctccgg tccgcctgga
    20161 tgcgcgcgct gagcggctcc ggccggcagg ccgaggccct cgcggcgtac gacgactacc
    20221 ggcagctcct cgcccgggag ctgggcctgg agccgggcgg cgcgatggcg gcccgctacc
    20281 ggatgatcct cgcgggtgac gaccgggccg ggacgggcgc cgccgcccgg ccgccggccg
    20341 ctccgccgcc cgacctcccc gacttcaccg ggcacggcga ggaactgcgc tacctcaccg
    20401 accgcttgga ggacgagggc gccggccgca tcgtgctgct gtcgggcccc gccggggccg
    20461 ggaagaccac gctggcggtg cgggccgccc acctgctcgg ggaccggttc gccgacgggc
    20521 ggctctgcgt gtccctgcgt gacgcggacg gccgtacccg ctcgctcccg gcggtgctcg
    20581 cggagctcgg tgaacggacc ggccaggccg ggctgtccgg gcccgaggcg tggcgggagt
    20641 ggctggcgcg gcaccgcgta ctggtgatcc tggacgacgt gcccgacgaa agcgccgtac
    20701 ggccgctgct cccgtgcggc gggctgggca gggtgctgct caccgcccgc ggccagctgg
    20761 gcggtctggc gcccgtggac cgggtctgcg taccgccgct cggcaccgca gagtcggtgc
    20821 aactgctcgc ggggctcgtc ggcgagggac gggtgcgggc cgaccgggag gccgcactgc
    20881 gcatcgtgcg cgcctgcggc gggtcgccgc tggcggtccg ggtgagcggg atgcggctcg
    20941 cggtgctccg ccacgtgccg ctgcgggagt tcgcggaccg gctcaccgac cccgccgggg
    21001 cgctggacga actgacctcc ggggacgtgt ccgtgcggcg gtggctggcc cacggctggg
    21061 aggcgctgcc cgaggagtgg ggccgggacg cgggacggct ggccgcgggc accggggagg
    21121 ggcccttcgg cctgaccgag gcggccgagg ccctcggctg cgacgagcgg cgcgccgtga
    21181 gggtggtgga ggcgctcatc gacgccggaa tggtgacttc gccctgcggt gaggtcaccg
    21241 ctcacgcggc gcagtacgaa ctgccccacc tgatacgcct gtacgcgcgc ggctcggggc
    21301 tcggtacccc cacccccgta ctgacctgag gccgagcgct gcccgggctc aggcgccggt
    21361 tccggccgcc cccccgtcgg cggccggaac cggcgggtca cggggacgcc ggagcggtac
    21421 gtcccggggg cgggagcccc acctgccccg ccaggaaggc gaggcactcg gcctgcaggg
    21481 ccaccgcgcg ggacgcggaa cggtcgccgt ggccgacccc gcgctccagc cgcagcagca
    21541 ccggaccggt acccgaagag gcgtgctgga gcgcggcgca catcttgcgg gcgtgcagcg
    21601 gatcggtccg ggtgtcgccg tccgcggcga ccagcagcac cgccgggtag gcggtcccgg
    21661 gcgtgacccg gtgatagggg gagtagccga gcagcgtcgg cagcagggcg ggatcctgag
    21721 cgctgccgta ctcgggcgtc cagctgggcc cgaggccgga cagttcgtag cggaccatgt
    21781 ccagcagggg cgccacgcac accacggcgg cgtacttctc cggctgctgg gtgagggcgg
    21841 cgcccaccag cagcccgccg ttggagccgc ccatgatcgc gaggcggccc ggttccgtcc
    21901 agccctcggc gatcaggtgg tccccggccg cggcgaagtc gtcgaaggtg ttctgcttgt
    21961 tcctcccgct gcccgcccgg tgccaggcct cgccctcctc gccgcccccg cgcaggcccg
    22021 cccaggcgaa caccccgccg gccctgaccc aggcgaggac ctgggcgcgg taccgcggcg
    22081 acatcgtccg gccgaagccg ccgtagccgg tcagcagcgc ggggcgcgcc acgtccggac
    22141 gcccggtggg ggagatcacg aacatgcgca ccgtcgtacc gtcccgcgag gggaaggcga
    22201 tctggcgggt gaccgcgccg ccgacgcccg gggcgtccgg ggcgtcgcgc tcccaacgcg
    22261 aggcgcggcc cgtccgggcg tcgaagcgca ggatccgggg cggagtgacg aagtcggtgt
    22321 aggcgaagta ggcctcgtga cccccgggcg gcccggccga gaagtcgccg accgcgccgg
    22381 tgccgggcag cgggaccgtg gcgacctgcc gtccctcgac caggtcgtgc acggtcacct
    22441 cggccaccgt gtcgcgggtc caggcggcca ggccgagcgg gtgtttgagc tccggtcccg
    22501 acagcacgac gaggtgggtc agtaccgcgt cgggccgttc ggggatcacc tcgcgccagg
    22561 cagcggggcc cagggccagt tcggccggcc ggcacgcgac gacgcgtccg cgagcggcgt
    22621 cgcggtcggt gcgcagccac accaggtccc gcggaccggt gccgggcacc gcgtacaggc
    22681 gggtggcggc gtccatgccc tcctggacgg gccgcagttc cgggcgctcc agcggccccg
    22741 ccgacaggtc ggccaggtag agatcggtgc cgcggccggt gccgagcgtg gccgtgacgc
    22801 cgagccagcg gccgtccgcg gtcacggaca cgctgtagaa ctgggtcttg tcccgcccct
    22861 caccgaagac cagggcgtcc gtctcggggt ccgtgccgac ccggtgcagg cacacccggc
    22921 ggtggtagcg cccctcgccg gggtgcggcg aagggtcgag gttcctgacg tagtagaacg
    22981 cctcaccgcc gggcagccag ccgatcgacg acctgcgcac ccggtccacc ggcccgtcga
    23041 cgatcctccc ggtggccacg tcgagcacct ggagcagcga gtcctccgtg ccgttccggg
    23101 acacctggaa ggccagcaga tcgccctcca cggagggctc ccaggcgtcg agcacggtgc
    23161 gtccggacgg gtcgagggca ctggggtcca gcagcacccg cccggtcgga tcagctcccg
    23221 cctccgccac catgagtacc ggatgctcct ggccggcgtc ctgccgcagc cagaagaccc
    23281 tgccgccgcg gacctcgggc gagcgggcgc ggtccacggc gtcgatcgcc gccacctccg
    23341 ccttccagtg ctccaggtcc gcccaggacg cccgctccgc ctcgtagagc gtctgctgct
    23401 ccgcgctcca gcggagcgtc gcgggggact cggcgtcctc cagcgggcgg tacgggtcgg
    23461 ggacgcgcag accgtgcgct tcctcgacga cgtcctgccg ctccgcgtgc ggatagcggc
    23521 gggtttgcgg gctcactctt tgctccctca tccatcggtg ggtcgggggt cgtcggaccg
    23581 gtcggtggcg cgggcggaga gttccccgtc gtcgtggtgg gccacgacct cggcgtcctg
    23641 cctctccttc gccgccgggt ccgcctggtc cgccggcgcg gccgtgtcct cgcccgctct
    23701 cgcggcgggc ttcccggcgc ccgtgtcggg cagggcggcc atcgcgaaga cgccggccaa
    23761 gaggacgatc agtcccgacg cggcgatgat cgtgtcgacg gggccgaacc ggagcccgcc
    23821 gagcgagccc ccgacgtccc gcagcacgga tccggcgagc cagccggaca gggccgcgga
    23881 cagcatcgac gccagcctcg tcaccgggta gaacacggcc atcacccggc cccggtagtc
    23941 cgggggcgcc gccgcgagca gcagcggtga catcgcggtg ttcagcatgg tgagcggaac
    24001 ggcgaacgcg aagaggaggg cgacaccgcc caggaagccg gtctgccggg agtaggccac
    24061 cagcagcaca ccgctcacca gcaggccgat ccaggtggtc cttcgcgccc cgagccactg
    24121 caccatccgg cccccgcaca gcgctcccgt gatgccgccc gcgcccatgg ccatgccgag
    24181 gtatccgtag aggtgggcgt ccgcgtggag gttgtcggtg gcgaagaaga cgttgagggt
    24241 gcccagcgcc ccggccccga actggcctat gacggcgagc aggagcagcg ccaccaggaa
    24301 ccggctgccc gcgaagaagc gcagtccgtc catgaactcc ttgcgcagcg cgccctgttg
    24361 ccgctcgacg ggcccccgct cggcggccgg ccgggcggag ccggtgccga gctcgcgtgc
    24421 gccgatggaa cggatcgcga tgtacgacac cgcgtacgaa aggccgttga agagcagggc
    24481 ccactgcagt ccgacggtga acagcagcgg cgcggcgagg ggcggcccga tgatccaggc
    24541 cgtctcaccg gtcgcctgcg cgatgcccgc cgccctggcg cggtccgcat ccccggtcac
    24601 caggtccgcg aggaccgcga agcgcgccgg ggagaagaac tggccggccg cgtggagcag
    24661 gagcacggtc acgtagatca gggcgagcca gacaccggcc gggagggcgc cggccggcag
    24721 gaaggtgatg accgtcagta cggccaccag gacgccgcgg agcacctcgc tgcgcagcat
    24781 cgtggcgcgc ttgtcccagc ggtcgacgaa cacgcccgcg agcggaccga tgaccagcac
    24841 ggcgacgccc gaagccatca cgatgccgct gaccgccaac ggcgcccacg actcgccctt
    24901 cgccagcacg gtggccaccc acagcaccag cgtcgtactg aagacggcgt ccccgacgga
    24961 cgagacggcc tggccgaacc agagccgggt gtagtcgcgg ttgatcaggg tcagccgcgg
    25021 cgtcatgacg gcctcggcga cgcgacgatc agcgccatga gggcggtgac cagggtcgtg
    25081 tggtacgccg cccggaagaa ctccccgccg gaggccgacg ggtccgccgc gctcgccgca
    25141 gaccgcccgg ggagcgcccc gtcgggccgc tgggcccgca ccaggcactc cacggccgcg
    25201 gctcccgagg gtgtgtccag cggctcgctc cccaggatga actgggtgag gaccagctcc
    25261 gcggccaggt cccacaggtc gtgctcgacg ctgtggcgca gcaagcggtc gaccaggtcc
    25321 cgggcgtgcg ccagggcgtc cccgcccagc ccgggggcgg tccggccgaa gtcgccgaga
    25381 tagaaggcgg tgtgcgtcac ggcgtacgcc tgcgggaggg tgagcggcgc gccgtccccc
    25441 gagggggcct ccccgggccc ggcggcgcgg aacgcgacga gcgggctgtg tggcaggagc
    25501 tccgtgtacg gctcgatggt gtggcggaca ccggccttgt ccgcgtagtg gcggacctcg
    25561 acgcgctggt agggggactt cccccgcggc gagaggaagg cggggtcgag ccccgcgagc
    25621 accgcgcgga cctgggcgtc gtcgatcgcg tcgggggcca gtgcggcgta gatcaacccg
    25681 tagccggacg tgtacttcgg gacctcggcg aacagccgcg ggaggtcagg gtcctgccag
    25741 agcccccgta ccagggcccc ggcctcgccc agcgcctgcg ggggctcggc caggcggtcc
    25801 gcgcagtggc agagcagcgc cagttccagc gccgccttcg cccttgcgag gggcgcc
//
