LOCUS       NZ_BMVE01000002        22217 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces goshikiensis strain JCM 4640 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVE01000002
VERSION     NZ_BMVE01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1126124)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650555.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:30:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,491
            CDSs (total)                      :: 7,410
            Genes (coding)                    :: 7,286
            CDSs (with protein)               :: 7,286
            Genes (RNA)                       :: 81
            rRNAs                             :: 2, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 44 of 125
            Pseudo Genes (incomplete)         :: 101 of 125
            Pseudo Genes (internal stop)      :: 9 of 125
            Pseudo Genes (multiple problems)  :: 27 of 125
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:38:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 388514
            Orig. end                         :: 410731
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVE01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22217
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22217
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22217
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12217](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12217)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(180..196)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.96"
                     /tool="antismash"
     misc_feature    complement(273..290)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.45"
                     /tool="antismash"
     misc_feature    complement(284..301)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.73"
                     /tool="antismash"
     gene            369..1265
                     /locus_tag="IE248_RS07055"
                     /old_locus_tag="GCM10010336_14340"
     CDS             369..1265
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965395.1"
                     /locus_tag="IE248_RS07055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14340"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_008743393.1"
                     /transl_table=11
                     /translation="MDFLRPASWEEALAAKAEFPTAVPIAGGTDVMVEINFDHRRPEYL
                     LDLNRIGLLREWEVAEDVVRLGASVPYTQIMENLRTELPGLALASHTVASPQIRNRGGV
                     GGNLGCASPAGDSHPALLAAGAEVEVESVRGSRLIPIDAFYTGVKRNALAPDELIKTVH
                     VKKADGPQQYSKVGSRNAMVIAVCAFGLALHPETRTVRTGIGSAAPTPIRAKAAEEFLN
                     AALEEGGFWESGKVVTPSIAKQFGDLASGAANPIDDVRGTAKYRRHAVGIMARRQLVWT
                     WEQYRGTGNGRSLEGAA"
     gene            1268..1885
                     /locus_tag="IE248_RS07060"
                     /old_locus_tag="GCM10010336_14350"
     CDS             1268..1885
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944663.1"
                     /locus_tag="IE248_RS07060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14350"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_037794981.1"
                     /transl_table=11
                     /translation="MRVNFTVNGRQQEADDVWEGESLLYVLRERLGLPGSKNACEQGEC
                     GSCTVRLDGVPVCSCLVAAGQVEGRDVVTVEGLADFAKQREEHGHGGACGSGGSAGGCG
                     AKGGVTLDAAKRWQARPGDSQTGEGVELSAIQQAFIDAGAVQCGFCTPGLLVQADALLE
                     ENSSPSDQDIREALSGNLCRCTGYEKILDAVRLAAARQSEAV"
     misc_feature    1275..1289
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.56"
                     /tool="antismash"
     gene            1888..4290
                     /gene="pucD"
                     /locus_tag="IE248_RS07065"
                     /old_locus_tag="GCM10010336_14360"
     CDS             1888..4290
                     /EC_number="1.17.1.4"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pucD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743395.1"
                     /locus_tag="IE248_RS07065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14360"
                     /product="xanthine dehydrogenase subunit D"
                     /protein_id="WP_100580451.1"
                     /transl_table=11
                     /translation="MAQNTRTVPAGTPTNVTQKHAKGGIGESTLRPDGTLKVTGEFAYS
                     SDMWHEDMLWGQTLRSTVAHAEIVSIDISEALALPGVYSILTYDDLPAEMKNYGLEIQD
                     TPVLANGRVRHHGEPVALVAADHPETARRAAAKIKIDYRELPLVTDEASALAEGAPLIH
                     EGRDDHHIGHVPHPNIVHRQPIIRGDVAEARKRADVIVEGEYVFGMQDQAFLGPESGLA
                     VPSEDGGVDLYVATQWLHSDLKQIAPVLGLPEEKVRMTLSGVGGAFGGREDISMQIHAC
                     LLALATNKPVKIVYNRFESFFGHVHRHPAKLHYEHGATKDGKLTHMKCRIVLDGGAYAS
                     ASPAVVGNASSLSVGPYVIEDVDIEAIALYTNNPPCGAMRGFGAVQACFAYEAQMDKLA
                     AKLGMDPVEFRQLNAMEMGTIMPTGQVVDSPAPVAELLRRVKARPLPPERQWETAGEGA
                     DVRALPGGLSNTTHGEGVVRGVGYAVGIKNVGFSEGFDDHSTARVRLEVINGEPVAMVH
                     TAMAEVGQGGVTVHAQIARTELGVTQVTIHPADTQVGSAGSTSASRQTYMTGGAVKNTC
                     EHVREALLEMGRRKNGSYHPAWAHAELLLEGGKVVTDGGEVLADIADILEGEAIDLELE
                     FRHRPTVPFDLVTGQGDGHVQYTFAAHRAVVEVDTELGLVKVVELATAQDVGKALNMLS
                     VVGQIQGGTIQGLGVAIMEEIIVDPKTAKVRNPSFTDYLIPTILDTPTIPVDVLELADP
                     NAPYGLRGMGEAPTLSSTPAVLAAIRQATGLELNKTPIRPEALTGTL"
     gene            4646..6109
                     /locus_tag="IE248_RS07070"
                     /old_locus_tag="GCM10010336_14370"
     CDS             4646..6109
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125408.1"
                     /locus_tag="IE248_RS07070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14370"
                     /product="NCS2 family permease"
                     /protein_id="WP_073796966.1"
                     /transl_table=11
                     /translation="MTQSSVEPKTSAEDAGDGSLTPAGRSWLDRYFHITHRGSNVGNEI
                     RGGVTTFMAMAYILLLNPLILSGKDVAGDTMSQKALITATAFAAALTTLLMGFVGKVPL
                     ALAAGLSVSGVLSSQVAPQMTWPQAMGMCVMYGVVICLLVVTGLREMIMNAIPLALKHA
                     ITMGIGLFVALIGLVKAGFVGNGGELSSPVLLGATGELAGWPVLIFCVTLIAIFMLQAR
                     KVRGAILIGIVGGTVLAAVLNAVADIDPKAWKNGAPELTGSAVSMPDFSLFGQVSFGGW
                     GDVGVMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLADDKGRMPGLSKALFIDGAGGAI
                     GGIAGGSGQTVFVESATGVGEGARTGLASVVTGLFFAACLFFTPITQIVPGEVASAALV
                     VIGAMMMQNARHVDWADTATAIPVFLTVALMPFTYSITAGVAAGVISYVAIKVAQGKAR
                     EIGAFMWALTVIFVVFFALHPIEGWLGVN"
     misc_feature    6150..6165
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.15"
                     /tool="antismash"
     gene            6221..7372
                     /locus_tag="IE248_RS07075"
                     /old_locus_tag="GCM10010336_14380"
     CDS             6221..7372
                     /EC_number="1.17.1.4"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675793.1"
                     /locus_tag="IE248_RS07075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14380"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_190030190.1"
                     /transl_table=11
                     /translation="MLDIAEELNRWVEQGRDFAVATVVAISGSAPRQPGAALAVDGDGT
                     AIGSVSGGCVEGAVYELCRQALEDGETVLERFGYSDDDAFAVGLTCGGVIDILVTPVPA
                     GSPARGAFAAALAAAARGEAAALARIAEGPAELMGRALVVRGDGSYEGGLGGHPELDRT
                     LAEEARAMLDAGRTGVVEMGADGRLCGEPLKVLVEASVPPPRMIVFGAIDFASALVRIG
                     KFLGYHVTLCDARPVFATRRRFPEADEIVVDWPHRYLESTDVDGRTVLCVLTHDAKFDV
                     PLLELALRLPVAYVGAMGSRRTHEDRNKRLRDVGVSELELARLRSPIGLDLGARSPEET
                     ALSIAAEIVANRRGGTGTSLTGAHVPIHHDGSKTAMARIGVVA"
     gene            7522..8754
                     /locus_tag="IE248_RS07080"
                     /old_locus_tag="GCM10010336_14390"
     CDS             7522..8754
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743398.1"
                     /locus_tag="IE248_RS07080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14390"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190030191.1"
                     /transl_table=11
                     /translation="MVDIREVPEADIDRAQELAYLVFHDRPDEEGRARHRTLLGHCDRL
                     GAYEGDALVGFMAAHRFRLSVPGADLPCPGLTFVAVAPTHRRRGVLTALMAEQLRRTGA
                     AGAPVAALWASEAAIYGRFGYGSATQGVTIEIDSTRPLALRIAPDRRPLRMIDPADAPA
                     LIGPAHEATRALRAGRPSRGPERWREEWLCEQDEEDEELSPPRIIALGDPGEPLAGYVI
                     YRTKPGGGSGPVRTPGLVRVDELEADTPAVAAALWECVAGLDLTGRVSAWGRPADDPLL
                     HFAADRDQVKVTEVFPALWLRLVDVRAALTARSWAAPVELVLELADVRLPANAGRFRLK
                     AGPGGATYERAAQAPDLELDVRELAACYLGGTRVVELVAAGLVREHTPGAAATLDAALR
                     TELLPHTADEF"
     gene            8898..9401
                     /locus_tag="IE248_RS07085"
                     /old_locus_tag="GCM10010336_14400"
     CDS             8898..9401
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS07085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_14400"
                     /product="hypothetical protein"
                     /protein_id="WP_159031929.1"
                     /transl_table=11
                     /translation="MGLAKRLLREDFTLSIGCRVSVTAGVGSTTVKWQVSRMAAGGGRR
                     PRKGDETVDFTCPRCRKTLSVAVESLAKARIKYEIYRALAWLLALSLLVTLPMLIHLGG
                     QTVEEGDDGAVRVVGWLVLAVAVAVIVAPGFFVAAGNYSGVKKLRLVRPGGGRTIWVQG
                     HRLF"
     gene            complement(9453..9845)
                     /locus_tag="IE248_RS07090"
                     /old_locus_tag="GCM10010336_14410"
     CDS             complement(9453..9845)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE248_RS07090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010336_14410"
                     /product="hypothetical protein"
                     /protein_id="WP_073796962.1"
                     /transl_table=11
                     /translation="MTAEAPARRTPDPASAPAADAGKERRQADRIEAWSIAWMLLAMLM
                     WGCFAFLMLSDYGPQSGDRALCRGPLVRPVSESSLCRDELRQWPALLGVLALAAVVTVV
                     AAATTVYAKVLSRLAHHEPPGARPQA"
     gene            complement(10001..12217)
                     /locus_tag="IE248_RS07095"
                     /old_locus_tag="GCM10010336_14420"
     CDS             complement(10001..12217)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743400.1"
                     /locus_tag="IE248_RS07095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14420"
                     /product="Geosmin synthase"
                     /protein_id="WP_073796961.1"
                     /sec_met_domain="T1TS (E-value: 4e-81, bitscore: 269.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFQLPDFYVPHPARLNPHLEEARVHTKRWARALGMLEGSGVW
                     EESDLDSHDYALLCAYTHPDCDSEALSLVTDWYVWVFFFDDHFLEMYKRSQDRAGAKAY
                     LDRLAAFMPMDLADGFPEPAGPVEAGLADLWERTVPAMSPHWRERFAESTRNLLNESMW
                     ELANINIGRVANPLEYIEMRRKVGGAPWSAGLVEYVSAEVPARVAHTRPLAVLRDAFSD
                     AVHIRNDLFSYEREVADEGELSNAVLVLETFLGCTTQEAAEASNDLLTSRLQQFEQTAL
                     GELPQLFADHAMDPAEIAAVLAYAKGLQDWQSGGHEWHMVSSRYMNKEARPTAPLSLPF
                     MPTGLGGAALDLRSVLEPRALERRRRSFSHVPFERTGPSVIPDIHMPFPLSLSPHHAHA
                     REGSVAWAREMGLLDPQPGDPGSAIWNEPKLRGYDFALCSAGIDPDATREALLLNACWL
                     TWGTYGDDYYPVVFAQAKNLPAAKATTARLIAMIPLDHTERPEPATAMERALGDLWVRT
                     SAQMGPRVRAEFRATLVSMLESWLWEVDNQIQNRIPDPVDYAEMRRRTFGSHLTMYLCR
                     LGQQGRGIPEEIYASGTIRSLENAAADAACMINDIFSYQKEVEVEGEVHNFVLVTRNFF
                     DIGYPEALRICHDLLTRRTEEFEHIVANQLPLLYDDWKLDAGARAGLDAYVGELEDWLA
                     GILNWHRKVRRYREEDLHGLPDLLSSGVWSSSFGMSAARLSLPR"
     gene            complement(12387..14408)
                     /locus_tag="IE248_RS07100"
                     /old_locus_tag="GCM10010336_14430"
     CDS             complement(12387..14408)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743401.1"
                     /locus_tag="IE248_RS07100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190030192.1"
                     /transl_table=11
                     /translation="MRLLKRPVPAEPAVSESERRLFGGPLRYDAGWANHEYAQLESGLL
                     STLRAMPRMVRGTLRLAWDTDRPALLTVAAAEAGQGVTSAVGLLVLSAVLRTLFGAGSP
                     AERLQEALPALAAGALVAVLGAVLASRSTAAAGRLEPKVERAAQEQYLHAAVGVELEAI
                     EDGEFRRLLDSAQWGPPSARRTVGACVATLGGLISLFATAGVLTVLHPLLLPMLLLIAA
                     PRGWGAMRVAQRRYLSVMAWVEHVRAARLIGQLLIARTSAPEVRVHGVGRYLLGHYRNM
                     AEHAEGEATRLAKDKAATELLAAALSGLAALVTYAAMGALIAAGRMDLAVAGTAVIAVR
                     AGSASLGALVATTNTLHEESLYVRDLERFVAEAGRRAIPSGGRPLPGRTGTIRLTEVGF
                     GYPDREEPALAGVSLTIEAGQVVALVGENGSGKSTLVKLLAGLHLPDTGTLTWDGVDVR
                     EADRTQVFDRVALLTQDFERWPVTARTNIAIGRPGDAGADGSVDQAAEVVAAARYTGAD
                     EVVAKLPHGYETLLARVFRGASELSGGQWQKFGLARTRYRDARVIVVDEPTSALDPAAE
                     IAAFDSIRGLAGPHRAVVLVTHRMSGVRHADVIYVLHEGRLVEQGSHEELLARDGRYAA
                     MFRMQAEQYAERHGPQPRGAGTPIPRQAPPPQKGSTVT"
     misc_feature    complement(14565..14581)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            complement(14789..18400)
                     /gene="cobN"
                     /locus_tag="IE248_RS07105"
                     /old_locus_tag="GCM10010336_14440"
     CDS             complement(14789..18400)
                     /EC_number="6.6.1.2"
                     /GO_function="GO:0051116 - cobaltochelatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1263: cobaltochelatase subunit CobN"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743402.1"
                     /locus_tag="IE248_RS07105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14440"
                     /product="cobaltochelatase subunit CobN"
                     /protein_id="WP_190030193.1"
                     /transl_table=11
                     /translation="MILLLSTSDTDLLSARAAADGPVPYRFANPSRLPLDDLPGLLDGV
                     DLVVVRLLGGLRAWQEGLDLLLAPAQTRPVVVLTGEQAPDAQLMEASTVPIGIAAEAHG
                     YLAHGGPANLDQLARFLSDTVLLTGHGFEPPAAAPTWGPLERTPGSTTGPRIAVLYYRA
                     HQMSGNTSFVHALCDAIEAKDAQALPLYVSSLRAPEPELIAALESADAVVTTVLAAGGT
                     KPATASAGGDDESWDAGALAGLGVPILQALCLTGSRSAWEENDEGLSPLDAATQVAVPE
                     FDGRLITVPFSFKELDEDGLPAYVADPERAARVAGIAVRHARLRHIERRDKKVALVLSA
                     YPTKHSRIGNAVGLDTPASAVELLRTLIAGGYDFGPVEDVPGLVSGDGDELIRALIEAG
                     GHDQDWLTEEQLARNPVRIPAADYKRWFSELPAELRDSVTEHWGEAPGNMFVDRSANPD
                     GDIVLAALRRGNLLILIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWIQARAEDGGFG
                     ADAMIHLGKHGNLEWLPGKNAGLSAACAPDAALGDLPLIYPFLVNDPGEGTQAKRRVHA
                     TLVDHLVPPMARAESYGDIARLEQHLDEYAQISAMDPAKLPAIRAQIWTLIQAAKLHHD
                     LGLEERPDDEGFDDFLLHVDGWLCEVKDAQIRDGLHVLGGAPAGEARVNLVLAILRARQ
                     IWGGTTALPGLREALGLDESAATRTTADQAEEAARALVQAMEDAHWAPEAVASVAAGHS
                     ADVAAVLDFAAREVVPRLAGTTDEIAHVVSALDGAFVPAGPSGSPLRGLVNVLPTGRNF
                     YSVDPKAVPSRLAWETGQALADSLLNRYRTDNGEWPASVGLSLWGTSAMRTSGDDVAEA
                     LALLGVRPVWDEASRRVTGLEPIPLDELGRPRIDVTLRISGFFRDAFPHVIGLLDDAVR
                     LAAGLEEPAEQNYVRAHAQADLAEHGDERRATTRIFGSRPGTYGAGILQLIDSRDWRTD
                     ADLAEVYTVWGGYAYGRGLEGRAAREEMESAYKRITVAAKNTDTREHDIADSDDYFQYH
                     GGMVATVRALRGTAPEAYIGDSTRPETVKTRTLVEETSRVFRARVVNPKWIEAMRRHGY
                     KGAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPANRAFLEEANPWALHGIAER
                     LLEAESRGMWEKPDPQILESLRQVYLDTEGNLEAEAE"
     regulatory      complement(18433..18590)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(18683..18698)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.48"
                     /tool="antismash"
     gene            18809..20050
                     /locus_tag="IE248_RS07110"
                     /old_locus_tag="GCM10010336_14450"
     CDS             18809..20050
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267283.1"
                     /locus_tag="IE248_RS07110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14450"
                     /product="cobalamin biosynthesis protein CobG"
                     /protein_id="WP_229895164.1"
                     /transl_table=11
                     /translation="MPQSPSATSRDEPVIRDRGDACPGALRLHAADDGFLARVRLPGGL
                     LTAAQAAALADAAERFGDGHLELTSRGNVQLRGLADGCGGALAELLDSVGLLPAPSHER
                     VRNIVASPLGDPAPVRALDRLLCADPGAAALSGRFLFAVDDGRGDVAALDPDVSLLARP
                     GGRALIRLGAAPDAAEVAAGDGPEAALEAARHFLDAAARAGTRAWRVAELPAEHALDAR
                     EFTARLAALGIPARYVADAPRPYAGPPAPGVHGDALCVLIPLGRLRSAQWRELPGALRT
                     TPWRSVIVGDTAARPAGLVTAPGSAWESVTACTGRPGCAKALADVRADARAVAERARGP
                     LSVHWSGCERRCGHPRGTDWVDAVATATGYRLTGPGVPGGPGGPASRHVPATAPELGAA
                     LRDARNTPRVSEEQ"
     gene            20055..20702
                     /locus_tag="IE248_RS07115"
                     /old_locus_tag="GCM10010336_14460"
     CDS             20055..20702
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267284.1"
                     /locus_tag="IE248_RS07115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14460"
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_037798395.1"
                     /transl_table=11
                     /translation="MSEYTVFEYEKDGAAIYRQSFATIRAEADLSGLPASVAQVAVRMI
                     HACGMTDLPKDLGYTPEVVLRARAALTAGAPILCDVQMVASGVTRGRLPADNEVICTLS
                     DPAVPELAAKMGTTRSAAALEVWRDRGLLEGSVIAVGNAPTALFRLLEMIEEGAPRPAA
                     VIGVPVGFIGAAESKDALAAHPSGLDHLIVRGRRGGSAIAAAAVNAIASVAE"
     gene            20699..22186
                     /locus_tag="IE248_RS07120"
                     /old_locus_tag="GCM10010336_14470"
     CDS             20699..22186
                     /EC_number="2.1.1.130"
                     /GO_function="GO:0030788 - precorrin-2
                     C20-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488481.1"
                     /locus_tag="IE248_RS07120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010336_14470"
                     /product="precorrin-2 C(20)-methyltransferase"
                     /protein_id="WP_073796959.1"
                     /sec_met_domain="TP_methylase (E-value: 6.3e-52, bitscore:
                     172.4, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAGRLYGVGLGPGDPSLMTLRAVEVIAEADVIAYHSARHGRSIA
                     RSIAAKHLRADHVEEPLVYPVTTETTDHPGGYQGAMEEFYEDCAARLAAHLDAGRTVAV
                     LAEGDPLFYGSYMHMHKRLADRYEAEVIPGVTSVSAAAARLGTPLVEGEEVLTILPGTL
                     PEEELTARLAATDSAVVMKLGRTFPAVRRAMEASGRLAEARYVERATMAGERTGILADT
                     DAETVPYFAVAVVPSRIGNPGSVPSGPGGVVVVGTGPAGPLWLTPETRRALADAEVLVG
                     YTTYLDRVPVKPGQIRHGSDNKVESERAEFALDLARRGKRVAVVSGGDPGVFAMATAVL
                     EVAGQPEYKDVQVKVLPGVTAANAAAAAAGAPLGHDYATISLSDRLKPWEVIAERLRAA
                     AAADLVLALYNPGSRSRTWQVAQAKELLLELRSPQTPVVVARDVGGPTQTVRVVTLAEL
                     EPAEVDMRTILLIGSSQTQVTDRPDGTRVTWTPRRYP"
ORIGIN
        1 tgggatccct caggtcggtc gtcatgactc cgcggaccgt ccggtcgagt tcttcctcgc
       61 cgcccagcag ccgcagcccc agcgcctcgg tttccagcag tgcgcgcagc cgcatgatgt
      121 cgccgccgat ctgtctcgat gttgccgttg gaaatcgggc aggtcatcgc atcctgcctt
      181 tcatacgaat ctacaagacg ggagaggccg ccagccaact ccttcatggt ttcggtgact
      241 gcacccgggg gacgcgcggc ttgtgtactg actccacacc gcgttaacag cacgtgaacg
      301 accagtcgag ggcccgaagg cctcctggct tgaagtgaac gacacgatga agaagaagag
      361 agccgcacat ggacttcctt cgccccgcca gctgggagga ggcgctcgcc gctaaggccg
      421 agttccccac cgctgtgccg attgcgggtg gcaccgatgt gatggtcgag atcaacttcg
      481 accaccgccg gccggagtac ctcctggacc tgaaccgcat cggtctgctg cgcgagtggg
      541 aggtcgccga ggacgtggtg cgcctgggcg cctccgtccc gtacacgcag atcatggaga
      601 acctccgcac ggagctcccg ggcctggcgc tggcctcgca caccgtcgcg tccccgcaga
      661 tccgcaaccg cggcggcgtc ggcggcaacc tcggctgcgc ctccccggcc ggtgactcgc
      721 accccgcgct gctcgcggcg ggcgccgagg tcgaggtgga gtccgtgcgc ggctcccggc
      781 tgatcccgat cgacgcgttc tacacgggcg tcaagcgcaa cgcgctggcc cccgacgagc
      841 tcatcaagac cgttcacgtg aagaaggcgg acggccccca gcagtactcc aaggtcggct
      901 cgcgcaacgc gatggtcatc gcggtctgcg ccttcggcct ggcgctgcac cccgagaccc
      961 gcaccgtccg taccggcatc ggttcggccg cgccgacccc gatccgcgcg aaggccgccg
     1021 aggagttcct gaacgccgcg ctcgaagagg gcggtttctg ggagtccggc aaggtcgtca
     1081 ccccgtcgat cgccaagcag ttcggtgacc tcgcctccgg cgcggccaac ccgatcgacg
     1141 acgtccgcgg cacggcgaag taccgccgtc acgcggtcgg catcatggct cgccgccagc
     1201 tcgtctggac ctgggagcag taccgcggta ccggaaacgg ccgctcgctt gaaggggctg
     1261 cgtaagcatg cgcgtcaatt tcactgtcaa cggccgtcag caggaagccg acgacgtgtg
     1321 ggagggcgag tccctcctct acgtcctgcg cgagcgcctg ggcctgccgg gttcgaagaa
     1381 cgcctgtgag cagggcgagt gcggttcctg caccgtccgc ctcgacggcg tgcccgtctg
     1441 ttcctgtctt gtggccgccg gccaggtcga gggccgcgac gtcgtgaccg tcgagggcct
     1501 ggccgacttc gccaagcagc gcgaggagca cggccacggc ggagcctgcg gcagcggcgg
     1561 cagcgccggc ggctgcggtg ccaagggcgg tgtcaccctc gacgcggcca agcgctggca
     1621 ggcccggccg ggcgactcgc agaccggcga gggtgtggag ctctccgcca tccagcaggc
     1681 gttcatcgac gccggcgccg tgcagtgcgg tttctgcacc ccgggtctgc tggtccaggc
     1741 cgacgcgctg ctggaggaga actcctcccc gtccgaccag gacatccgtg aggccctgtc
     1801 cggcaacctc tgccgctgca cgggctacga gaagatcctc gacgcggtcc gcctcgcggc
     1861 cgcccggcag tcagaggcgg tctgaccatg gctcagaaca cccgtacggt tcccgccggc
     1921 acgccgacca acgtcaccca gaagcacgcc aagggcggca tcggcgagtc cacgctccgc
     1981 ccggacggca ccctcaaggt caccggcgag ttcgcgtact cctccgacat gtggcacgag
     2041 gacatgctgt ggggccagac cctgcgcagc accgtggcgc acgccgagat cgtctcgatc
     2101 gacatctccg aggccctcgc gctgccgggc gtctactcga tcctgacgta cgacgacctg
     2161 ccggccgaga tgaagaacta cggcctggag atccaggaca ccccggtgct cgccaacggc
     2221 cgggtgcgcc accacggtga gccggtcgcc ctcgtggccg ccgaccaccc ggagaccgcc
     2281 cgccgcgcgg ccgccaagat caagatcgac taccgtgagc tgccgctcgt cacggacgag
     2341 gcctccgccc tcgccgaggg cgcgccgctg atccacgagg gccgcgacga ccaccacatc
     2401 ggtcacgtcc cgcacccgaa catcgtgcac cgccagccga tcatccgcgg cgacgtggcc
     2461 gaggcccgca agcgcgccga cgtcatcgtc gagggcgagt acgtcttcgg catgcaggac
     2521 caggccttcc tcggcccgga gtccggtctg gccgtgccct ccgaggacgg cggcgtcgac
     2581 ctctacgtcg ccacccagtg gctgcactcg gacctcaagc agatcgcccc cgtcctcggc
     2641 ctgcccgagg agaaggtgcg catgacgctc tcgggcgtcg gcggcgcctt cggcggccgc
     2701 gaggacatct cgatgcagat ccacgcctgc ctcctggccc tcgccaccaa caagccggtc
     2761 aagatcgtct acaaccggtt cgagtccttc ttcgggcacg tgcaccgcca cccggcgaag
     2821 ctccactacg agcacggcgc caccaaggac ggcaagctca cgcacatgaa gtgcaggatc
     2881 gtcctggacg gcggcgcgta cgcgtccgcc tccccggcgg tcgtgggcaa cgcctcctcc
     2941 ctctcggtcg gcccgtacgt catcgaagac gtcgacatcg aggcgatcgc gctctacacg
     3001 aacaacccgc cctgcggcgc gatgcgcggc ttcggcgccg tccaggcctg cttcgcctac
     3061 gaggcccaga tggacaagct cgcggcgaag ctgggcatgg acccggtcga attccgccag
     3121 ctgaacgcca tggagatggg cacgatcatg cccaccggcc aggtcgtgga ctccccggcg
     3181 cccgtcgccg agctgctgcg ccgggtcaag gcccgcccgc tgccgccgga gcgccagtgg
     3241 gagaccgccg gcgagggcgc ggacgtccgc gcgctgcccg gcggcctctc caacaccacc
     3301 cacggcgagg gcgtcgtccg cggcgtcggc tacgcggtcg gcatcaagaa cgtcggcttc
     3361 tccgagggct tcgacgacca ctcgaccgcc cgcgtgcgcc ttgaggtcat caacggcgag
     3421 cccgtcgcga tggtccacac ggccatggcg gaggtcggcc agggcggtgt caccgtccac
     3481 gcgcagatcg cccgtacgga gctgggcgtc acccaggtga ccatccaccc ggccgacacg
     3541 caggtcggct ccgccggttc cacgtccgcc tcgcggcaga cgtacatgac cggtggcgcc
     3601 gtgaagaaca cctgcgagca cgtccgcgag gccctgctgg agatgggccg ccgcaagaac
     3661 ggctcgtacc acccggcctg ggcgcacgcc gagctgctcc tggagggcgg caaggtcgtc
     3721 accgacggcg gcgaggtcct cgcggacatc gccgacatcc tcgaaggcga ggcgatcgac
     3781 ctggagctgg agttccggca ccggccgacc gtcccgttcg acctggtcac cggccagggc
     3841 gacggccacg tccagtacac cttcgccgcg caccgcgcgg tggtggaggt ggacaccgag
     3901 ctcggcctcg tcaaggtcgt ggagctcgcc accgcgcagg acgtaggcaa ggccctgaac
     3961 atgctctccg tggtcggaca gatccagggc ggcaccatcc agggcctggg cgtcgcgatc
     4021 atggaagaga tcatcgtgga cccgaagacc gcgaaggtgc gcaacccctc cttcacggac
     4081 tacctgatcc cgaccatcct cgacaccccg accatcccgg tcgacgtcct ggagctcgcc
     4141 gacccgaacg cgccgtacgg ccttcgcggc atgggcgagg cccccaccct gtcgtccacc
     4201 ccggccgtcc tcgcggcgat ccggcaggcg accggtctgg agctcaacaa gacgccgatc
     4261 cgtccggaag ccctcaccgg caccctctag gacggcgctc tccgggggcc gagaggcccc
     4321 cggaccccaa gctctccggg cggtgtgacc agggaacgtc acacttgccg gccgcaccgc
     4381 ccggagtacg aaagcccgga ggacgaaaac gccgcaccgc tcgcggcccg tccaccggca
     4441 ccatcccccc gcagcaaccc gggggcacca ccaccccggt gctcccgcca gtaccgcaga
     4501 acccccgcag tacccgcagt acacgcatcg acattcgcgt cgcctcgggc cgtcaccccg
     4561 ggtcgtgcag ccaaacggcg tttcccaaat cccgcgtctc caatctccaa gcgggtgccc
     4621 ctttgaacct tgggagttag gcaccatgac ccagtcgtcc gtagagccca agaccagtgc
     4681 ggaggatgcc ggcgacggct ctctcacccc cgccgggcgt tcttggctcg accggtactt
     4741 tcacatcacg cacagaggct ccaacgtcgg caatgagatt cgtggcggcg tcacgacctt
     4801 catggcgatg gcgtacatcc tcctgctcaa tcccctgatc ctctccggca aggacgtcgc
     4861 cggggacacc atgagccaga aggccctgat cacggccacg gccttcgccg cggccctcac
     4921 cacgctcctg atgggcttcg tgggcaaggt cccgctcgcc ctggccgccg gactgtccgt
     4981 ctccggcgtg ctgtcctcgc aggtcgcccc gcagatgacc tggccgcaag ccatgggcat
     5041 gtgcgtcatg tacggcgtgg tgatctgtct cctggtcgtc accggcctcc gcgagatgat
     5101 catgaacgcg atccccctcg cgctcaagca cgccatcacc atgggcatcg gcctgttcgt
     5161 ggccctcatc ggcctggtga aggccggttt cgtgggcaac ggcggggaac tttcctcccc
     5221 cgtgctcctc ggcgccaccg gtgagctcgc cggctggccc gtcctgatct tctgcgtgac
     5281 cctgatcgcc atcttcatgc tccaggcgcg caaggtccgc ggcgcgatcc tgatcggaat
     5341 agtcggcgga accgtcctcg cggccgtcct caacgccgtc gcggacatcg acccgaaggc
     5401 ctggaagaac ggcgccccgg agctcaccgg ctccgcggtc tcgatgccgg acttctcgct
     5461 gttcggccag gtctccttcg gcggctgggg cgacgtcggc gtgatgacgg tcggcatgat
     5521 cgtcttcacc ctcgtcctcg ccggcttctt cgacgcgatg gccaccatca tcggcgtcgg
     5581 caccgaggcc aagctcgccg acgacaaggg ccggatgccg ggcctgtcca aggcgctgtt
     5641 catcgacggc gccggagggg ccatcggcgg catcgcgggc ggctccggcc agaccgtgtt
     5701 cgtcgagtcc gccaccggcg tcggcgaggg agcccgtacc ggtctcgcct ccgtcgtcac
     5761 cggcctgttc ttcgccgcct gcctcttctt caccccgatc acgcagatag tcccgggtga
     5821 ggtcgcctcc gcggccctgg tcgtcatcgg cgcgatgatg atgcagaacg cccgccacgt
     5881 ggactgggcc gacaccgcga ccgccatccc ggtcttcctg accgtggccc tcatgccctt
     5941 cacgtactcg atcaccgcgg gcgtcgcggc cggtgtgatc tcctacgtgg ccatcaaggt
     6001 cgcccagggc aaggcccgcg agatcggcgc cttcatgtgg gcactgaccg tgatcttcgt
     6061 ggtcttcttc gccctccacc cgatcgaggg ctggctcgga gtcaactaga tcaccccacg
     6121 tcaccccgat cacccgggtg accagcggct tgtccctctg gtcggcgccg cgcccgccac
     6181 tcatccgata ctggaaacga acccctccga ggaggccgaa atgctggaca tcgccgagga
     6241 actgaaccgg tgggtcgagc agggacgtga cttcgcggtc gccaccgtcg tggcgatcag
     6301 cgggagcgcg ccccggcagc ccggtgccgc gctcgccgtc gacggcgacg gcaccgcgat
     6361 cggttcggtc tccggcggat gcgtggaggg cgcggtgtac gagctgtgcc ggcaggcgct
     6421 ggaggacggc gagaccgtcc tggagcgctt cggctacagc gacgacgatg ccttcgccgt
     6481 gggtctgacc tgcggcggag tcatcgacat cctggtgacc ccggtccccg cgggctcccc
     6541 cgcgcggggg gcgttcgcgg ccgcgctggc cgccgccgcc cgcggggagg cggcggcgct
     6601 cgcccggatc gccgagggcc ccgcggagct gatgggccgc gccctggtcg tccgcggcga
     6661 cggctcgtac gagggcggcc tcgggggcca ccccgagctg gaccgcaccc tcgccgagga
     6721 ggcccgcgcc atgctcgacg cgggcaggac cggcgtcgtg gagatgggcg ccgacggccg
     6781 gctctgcgga gagccgctga aggtactggt cgaggccagc gtgccgccgc cgcggatgat
     6841 cgtcttcggc gccatcgact tcgcctccgc cctggtgcgg atcggcaagt tcctcggcta
     6901 ccacgtgacg ctgtgcgacg cccggcccgt gttcgccacg cgccggcgct tccccgaggc
     6961 ggacgagatc gtggtcgact ggccgcaccg ctacctggag agcacggacg tggacggccg
     7021 gaccgtactg tgcgtcctca cccacgacgc caagttcgac gtcccgctcc tcgaactggc
     7081 cctcaggctt cccgtcgcct acgtcggcgc catgggctcc cgccgcaccc acgaggaccg
     7141 caacaagcgg ctccgcgacg tcggcgtgag cgagctcgaa ctggcccggc tgcgctcccc
     7201 gatcggcctg gacctcggcg cccgctcccc ggaggagacc gcgctgtcca tcgccgccga
     7261 gatcgtcgcc aaccggcgcg gcggcaccgg cacctcgctg accggcgcac acgtacccat
     7321 ccaccacgac ggctcgaaga cggcgatggc caggatcggc gtcgtcgcct gaagggacgc
     7381 ccccgaaccg ccgaggaacc aaaccaccgg cggccgcccg acgctcccaa gttcggagag
     7441 ggggacgggg ggtggtctcg tggggggctt tccggccaat atggggtgag cggtcctcga
     7501 tgaccgatta gtctccggat catggtggac atccgcgagg tacccgaggc cgacatcgac
     7561 cgcgcccagg agctcgccta cctggtcttc cacgaccggc ccgacgagga ggggcgcgcc
     7621 cgtcaccgca ccctgctggg ccactgcgac cggctgggcg cctacgaggg cgacgcgctg
     7681 gtcgggttca tggccgcgca ccgcttccgg ctctcggttc cgggggcgga tctgccctgc
     7741 cccgggctga ccttcgtcgc cgtcgccccc acccaccgcc gccggggcgt gctcaccgcg
     7801 ctcatggccg agcagttgcg ccgcaccggg gcggcgggcg ccccggtcgc cgccctgtgg
     7861 gcctccgagg ccgcgatcta cgggcggttc ggctacggat ccgccaccca gggcgtcacc
     7921 atcgagatcg actccacccg gccgctcgcc ctgcgcatcg ccccggaccg gcggccgctg
     7981 cggatgatcg acccggccga cgcccccgcc ctgatcggcc ccgcccacga ggccacccgc
     8041 gccctgcggg ccggccgccc gagccgcggt cccgagcggt ggcgcgagga gtggctgtgc
     8101 gaacaggacg aggaggacga ggagctcagc ccgccccgga tcatcgccct cggggatccc
     8161 ggcgagccgc tcgccgggta cgtgatctac cgcaccaagc cggggggcgg cagcgggccc
     8221 gtccgcaccc cgggcctggt ccgggtcgac gaactggagg cggacacccc ggccgtggcc
     8281 gcggcgctct gggagtgcgt ggccggcctc gacctcaccg gccgggtcag cgcctggggc
     8341 cgcccggccg acgacccgct gctgcacttc gccgccgacc gggaccaggt caaggtcacc
     8401 gaggtgttcc cggcgctctg gctgcggctg gtcgacgtac gggccgcgct gaccgcgcgg
     8461 tcgtgggccg cgcccgtgga actggtgctg gagctggccg acgtacggct gcccgccaac
     8521 gccgggcggt tccggctgaa ggcggggccg ggcggggcga cgtacgaacg cgccgcccag
     8581 gccccggacc tggagctgga cgtccgggag ctggccgcct gctacctggg cgggacccgg
     8641 gtcgtcgaac tggtcgccgc cgggctggtg cgcgagcaca ccccgggggc ggcggcgacg
     8701 ctcgacgccg ccctgcgcac tgagctgctg ccgcacaccg ccgacgagtt ctaggccccg
     8761 ccgcctgtgg tggtgtctct ggttcaacag ccttaagtgt cggcctagtt gggcgttgtt
     8821 cgggtggggg ccgggggagc gggactacac tctggctccc tccgtggggg cacggggtgt
     8881 gagggccggg gggttccgtg gggttggcca agcggttgct gagggaggac ttcaccctga
     8941 gcatcgggtg ccgcgtcagt gtgacggcgg gagtgggctc gaccaccgtc aagtggcagg
     9001 tctcccgcat ggctgcgggt ggcggccgtc ggccgcgcaa gggcgacgag accgtcgact
     9061 tcacctgccc gcgatgccgc aagacgctct ccgtcgccgt cgagagcctc gccaaggcgc
     9121 ggatcaagta cgagatctac cgcgccctcg cctggctcct ggcgctctcg ctgctcgtca
     9181 ccctccccat gctcatccac ctcggcggac agaccgtcga ggagggggac gacggggcgg
     9241 tgcgtgtcgt gggatggctg gtcctcgccg tcgccgtcgc cgtcatcgtc gccccgggct
     9301 tcttcgtggc ggccgggaac tactcgggcg tcaagaagct ccggctcgtc cggcccggcg
     9361 gcggcaggac catctgggtg cagggacacc ggctgttctg acggggcgcg gggcacgggc
     9421 cacggcgcgc cgcgcacggt tccgccggag ggtcaggcct gcggccgcgc gccgggcggc
     9481 tcgtggtggg ccaggcggga gaggaccttg gcgtacaccg ttgtcgccgc cgcgacgacg
     9541 gtcacgacgg ccgccagcgc gaggacgccc agcagggcgg gccactggcg cagctcgtcg
     9601 cggcacaggc tgctctcgga caccgggcgg accagcgggc cccggcacag ggctctgtcc
     9661 ccggactggg ggccgtagtc ggagagcatc aggaaggcga agcatcccca catcagcatg
     9721 gccaggagca tccacgcgat ggaccacgcc tcgatgcggt ccgcttgccg gcgttccttt
     9781 ccggcgtccg ccgctggggc gctcgcggga tcgggcgtcc gccgggccgg tgcttcggca
     9841 gtcatgtctc cccctcttgg ccaacgctga acggacgtca gtccatcacg cggcgccggc
     9901 ccaccgcgag ggtgtttccg gaagggcaac gcgatgtccg cggaggccgg gcggtggccg
     9961 gagcgggccc gggccggggc ttccgcggac atcggggcgg tcagcggggc agggagaggc
    10021 gggccgccga catgccgaag gaggagctcc agaccccgct ggagagcagg tcgggcaggc
    10081 cgtgcaggtc ctcctcgcgg taacgccgga ccttgcggtg ccagttgagg atgccggcca
    10141 gccagtcctc cagctccccg acgtacgcgt cgagcccggc gcgggccccc gcgtccagct
    10201 tccagtcgtc gtacagcagc ggcagctggt tcgcgacgat gtgctcgaac tcctcggtgc
    10261 gccgcgtcag caggtcgtgg cagatgcgca gcgcctcggg gtagccgatg tcgaagaagt
    10321 tccgggtgac gagcacgaag ttgtggacct cgccctcgac ctccacctcc ttctggtagg
    10381 agaagatgtc gttgatcatg caggcggcat cggcggccgc gttctccagc gaccggatcg
    10441 tcccggaggc gtagatctcc tcggggatgc cccggccctg ctgccccagc cggcacaggt
    10501 acatcgtcag gtgcgagccg aacgtgcggc ggcgcatctc cgcgtagtcc accgggtccg
    10561 ggatccggtt ctggatctgg ttgtccacct cccacagcca gctctccagc atggacacca
    10621 gcgtcgcccg gaactcggcg cggacccgcg ggcccatctg cgccgaggtg cgcacccaca
    10681 ggtcgcccag cgcccgctcc atcgccgtcg ccggctccgg ccgctcggtg tggtcgagcg
    10741 ggatcatcgc gatcagccgg gccgtggtcg ccttcgccgc cgggaggttc ttggcctggg
    10801 cgaacaccac cgggtagtag tcgtcgccgt acgtgcccca ggtcagccag cacgcgttca
    10861 gcagcagcgc ctcgcgggtg gcgtcggggt cgatgccggc ggagcagagc gcgaagtcgt
    10921 aaccgcgcag cttgggttcg ttccagatcg ccgaaccggg gtcaccgggc tgcgggtcca
    10981 gcagccccat ctcccgggcc caggccaccg atccctcgcg cgcgtgggcg tggtgcgggc
    11041 tcagggagag cgggaacggc atgtggatgt ccgggatcac ggacggcccg gtgcgctcga
    11101 acgggacgtg ggagaaggag cggcggcggc gctccagcgc gcgcggctcc aggacggagc
    11161 gcaggtcgag ggcggctccg ccgagcccgg tcggcatgaa gggcagcgag agcggcgcgg
    11221 tggggcgggc ctccttgttc atgtagcggc tggagaccat gtgccactcg tggccgcccg
    11281 actgccagtc ctggagcccc ttcgcgtagg cgaggacggc ggcgatctcg gccgggtcca
    11341 tcgcgtggtc ggcgaagagc tgggggagtt caccgagcgc ggtctgctcg aactgctgga
    11401 gccgtgaggt cagcaggtcg ttggaggcct cggcggcctc ctgggtggtg cagccgagga
    11461 aggtctccag cacgaggacg gcgttggaga gttcgccctc gtcggccacc tcgcgctcgt
    11521 aggagaagag gtcgttcctg atgtgcacgg cgtccgagaa ggcgtcgcgc agcacagcga
    11581 gcggccgggt gtgcgcgacc cgcgccggga cctcggcgga gacgtactcg accagcccgg
    11641 ccgaccaggg ggcgccgccc accttgcggc gcatctcgat gtactccagc gggttcgcca
    11701 cccgcccgat gttgatgttg gcgagctccc acatcgactc gttgagcagg ttcctggtcg
    11761 actcggcgaa ccgttcccgc cagtgcggcg acatggcggg cacggtccgc tcccacaggt
    11821 ccgcgaggcc cgcctcgacc gggcccgcgg gctcggggaa gccgtcggcg aggtccatcg
    11881 gcatgaacgc ggcgagcctg tcgaggtacg ccttggcgcc ggcgcggtcc tgggagcgct
    11941 tgtacatctc caggaagtga tcgtcgaaga agaacaccca cacgtaccag tcggtcacca
    12001 gcgacagcgc ctcgctgtcg cagtcggggt gggtgtacgc gcacagcagg gcgtagtcgt
    12061 gcgagtcgag gtcgctctcc tcccagacgc cggacccctc cagcattccg agggcgcgcg
    12121 cccaccgctt ggtgtggacc cgcgcctcct ccagatgggg gttcagtcgc gccggatggg
    12181 gcacgtagaa atccggcagt tggaacggct gcgtcacggc ggggtgagcc tttcgtctgt
    12241 ccgtatcggg gctgtctcgg acgcgggcgg acccggtccc gggcaccgcg cacgccgaag
    12301 tgcgggggcc cggtcgcccg ggcccccgca cgagaccagc agtgctctac ccctgacgcc
    12361 cctgggataa gggggagttc accgcatcag gtgacggtgc tgcctttctg tggcggcggg
    12421 gcctgccggg ggataggggt gcccgccccc cgaggctgtg gcccgtgccg ctcggcgtac
    12481 tgctccgcct gcatccggaa catcgccgcg taccgcccgt cccgcgccaa cagctcctcg
    12541 tgggagccct gttcgacgag ccggccctcg tgcaggacgt agatgacatc cgcgtgccgc
    12601 acccccgaca tgcggtgcgt gacgaggacg accgcccggt gcggaccggc caggccgcgg
    12661 atgctgtcga acgcggcgat ctccgccgcc gggtccaggg ccgaggtggg ctcgtccacg
    12721 acgatgacac gggcgtcgcg gtaacgggtg cgggccaggc cgaacttctg ccactgcccg
    12781 ccggagagct ccgaggcacc ccggaagacc cgggcgagca gcgtctcgta cccgtgcggc
    12841 agcttcgcga cgacctcgtc ggcccccgtg taccgggccg cggccaccac ctccgccgcc
    12901 tggtcgaccg agccgtccgc ccccgcgtcg ccgggccgcc cgatggcgat gttggtacgg
    12961 gcggtcaccg gccagcgttc gaagtcctgg gtcagcaggg cgacccggtc gaagacctgc
    13021 gtccggtcgg cctcccggac gtccaccccg tcccaggtca gcgtgcccgt gtcgggcagg
    13081 tgcagaccgg cgaggagttt gacgagggtg ctcttgccgg agccgttctc cccgaccagg
    13141 gccaccacct ggcccgcctc gatcgtcagc gacaccccgg ccagggccgg ctcctcccgg
    13201 tcggggtagc cgaaccccac ctcggtgagc cggatcgtgc ccgtccgccc gggcagcggc
    13261 cgcccgccgc tcgggatggc gcggcgcccc gcctcggcga cgaaccgctc caggtcccgg
    13321 acgtacaggg actcctcgtg cagggtgttg gtggtggcga cgagcgcccc caggctcgcg
    13381 gagccggcgc gcaccgcgat cacggcggtg ccggccaccg ccaggtccat ccgcccggcg
    13441 gcgatcagcg cgcccatcgc ggcgtacgtg acgagcgcgg cgagcccgga gagggcggcg
    13501 gcgagcagtt cggtggccgc cttgtccttg gcgagccggg tggcctcgcc ctcggcgtgc
    13561 tcggccatgt tgcggtagtg gcccagcagg tagcggccga cgccgtgcac ccggacctcg
    13621 ggagccgacg tacgggcgat cagcagctgc ccgatcagcc gggcggcccg gacgtgctcc
    13681 acccaggcca tcaccgacag gtagcggcgc tgcgccaccc gcatcgcgcc ccagccgcgc
    13741 ggggcggcga tcagcagcag catcggcagc agcagcgggt gcagcacggt cagcaccccg
    13801 gcggtcgcga acagggagat cagcccgccc agggtggcca cgcaggcgcc gacggtccgg
    13861 cgggccgacg gcggccccca ctgggcgctg tccagcagcc gccggaactc cccgtcctcg
    13921 atggcctcca gctcgacccc gacggcggcg tgcaggtact gctcctgcgc ggcccgctcg
    13981 accttgggct ccagccgccc ggcggccgcc gtcgaccggg aggccaggac ggctcccagt
    14041 acggcgacca gcgccccggc ggcgagggcg ggcagggcct cctgcagccg ctcggcgggg
    14101 ctgcccgcgc cgaacagggt acggagcacc gcgctcagga cgagcagccc gacggcggag
    14161 gtgacgccct ggccggcctc ggcggcggcg acggtgagca gcgcgggccg gtcggtgtcc
    14221 caggcgagcc ggagggtgcc gcggaccatc cggggcatgg cgcgcagggt gctgagcagc
    14281 ccgctctcca gctgggcgta ctcgtggttg gcccagccgg cgtcgtagcg cagcgggccg
    14341 ccgaagagcc ggcgctcgct ctcggagacg gcgggttcgg cgggcacggg ccgcttgagg
    14401 agcctcatgc gcggccacct ccgccccgcg gggtcgaaca ccacatgaac gtgcacggat
    14461 cgcaagattc ctcccggggt accgcgacgg gcgaactgac gccggaagaa cgcggctgct
    14521 cagagcgccg tcacgggccg ccgggagcga atgctcgtac gcagttgcga gggctgtgcc
    14581 gaccccaagg ggcgcccggg ccccggcccg tgacgcggcg ttcgaatcac ccgcgggtgt
    14641 gcgggacccc cttcgaggta ttgcgtcgat atccggccgc cgatcacatt cccgtcatgg
    14701 acatggccag acgaggaccg cccccgcgcc gtgcgggcgc gggggcggtc tcgggaatct
    14761 ccgggagcct tcgggaagct ccgggcggtt actccgcctc ggcctccagg ttgccctcgg
    14821 tgtccaggta cacctggcgc agggactcca ggatctgcgg gtccggcttc tcccacatgc
    14881 cgcgcgactc cgcctccagc aggcgctccg cgatgccgtg cagggcccag gggttggcct
    14941 cctccaggaa ggcgcggttg gccggatcca ggacgtacgt ctccgtcagc ttgtcgtaca
    15001 tccagtccgc gaccacgccc gtcgtggcgt cgtagccgaa gaggtagtcc accgtcgccg
    15061 ccagctcgaa ggcgcccttg tagccgtggc ggcgcatcgc ctcgatccac ttggggttca
    15121 cgacgcgggc gcggaagacg cgcgaggtct cctccaccag ggtgcgggtc ttgaccgtct
    15181 ccgggcgggt ggagtcgccg atgtacgcct ccggggccgt gccgcgcagc gcgcggacgg
    15241 tggccaccat gccgccgtgg tactggaagt agtcgtccga gtcggcgatg tcgtgctcgc
    15301 gggtgtccgt gttcttcgcg gccaccgtga tccgcttgta ggcgctctcc atctcctcgc
    15361 gcgccgcccg gccctccaga ccgcggccgt aggcgtaacc gccccacacc gtgtagacct
    15421 cggcgaggtc ggcgtccgtg cgccagtcgc gcgagtcgat cagctggagg atgcccgcgc
    15481 cgtacgtgcc cgggcgcgag ccgaagatac gggtcgtcgc gcgccgctcg tcgccgtgct
    15541 cggcgaggtc cgcctgggcg tgggcccgga cgtagttctg ctccgcgggc tcctccagcc
    15601 ccgccgccag ccgtaccgcg tcgtccagca gcccgatgac gtgcgggaac gcgtcccgga
    15661 agaagcccga gatgcgcagc gtgacatcga tgcgggggcg gcccagctca tcgagcggga
    15721 tcggctccag acccgtgacg cggcgcgagg cctcgtccca gaccgggcgg acgcccagca
    15781 gggcgagggc ttccgccacg tcgtcgccgg aggtgcgcat cgcgctcgtg ccccacagcg
    15841 acaggccgac ggaggcgggc cactcgccgt tgtccgtgcg gtaccggttc agcagcgagt
    15901 ccgccagcgc ctgcccggtc tcccacgcga ggcgggaggg gacggccttc gggtccacgg
    15961 agtagaagtt ccggccggtc ggcaggacgt tcaccaggcc gcgcagtggc gagccggacg
    16021 ggcccgccgg gacgaaggca ccgtccagcg cgctgaccac gtgcgcgatc tcgtcggtgg
    16081 tgccggccag gcgcgggacg acctcacggg ccgcgaagtc cagtacggcc gccacgtccg
    16141 ccgagtgccc ggcggcgacc gaagccaccg cctccggcgc ccagtgcgcg tcctccatcg
    16201 cctggaccag cgcgcgggcc gcctcctccg cctggtcggc ggtggtgcgg gtggccgccg
    16261 actcgtcgag gcccagcgcc tcgcgcaggc ccggcagggc cgtcgtaccg ccccagatct
    16321 gccgggcgcg caggatcgcc aggaccaggt tgacccgggc ctcgccggcc ggggcgccgc
    16381 ccaggacgtg cagaccgtcg cggatctggg cgtccttgac ctcgcacagc cagccgtcga
    16441 cgtgcagcag gaagtcgtcg aagccctcgt cgtccgggcg ctcttcgagg cccaggtcgt
    16501 ggtggagctt cgcggcctgg atcagggtcc agatctgggc gcggatggcc ggcagcttcg
    16561 ccgggtccat cgccgagatc tgcgcgtact cgtccaggtg ctgctccagg cgggcgatgt
    16621 cgccgtacga ctccgcgcgc gccatcggcg gcaccaggtg gtcgaccagg gtggcgtgca
    16681 cccggcgctt ggcctgggtg ccctcaccgg ggtcgttgac caggaacggg tagatgagcg
    16741 gcaggtcgcc gagggcggcg tcgggcgcgc aggccgccga caggccggcg ttcttgcccg
    16801 gcagccactc caggttgccg tgcttgccca ggtggatcat cgcgtcggcg ccgaagccgc
    16861 cgtcctcggc gcgcgcctgg atccagcggt acgcggccag gtagtggtgc gagggcggca
    16921 ggtccgggtc gtggtagatc gcgatcgggt tctccccgaa gccgcgcggc ggctggatca
    16981 ggatcagcag gttgccgcgc cgcagggccg cgaggacgat gtcgccgtcc gggttcgcgg
    17041 agcggtcgac gaacatgttg cccggggcct cgccccagtg ctcggtgacg ctgtcgcgca
    17101 gctcggccgg cagctcggag aaccagcgct tgtagtcggc ggccgggatc cggaccgggt
    17161 tgcgggccag ctgctcctcg gtcagccagt cctggtcgtg gccgccggcc tcgatcaggg
    17221 cgcggatcag ctcgtcgccg tcgccggaga ccagacccgg gacgtcctcg acggggccga
    17281 agtcgtagcc gcccgcgatg agggtgcgca gcagctccac ggcgctggcc ggggtgtcga
    17341 gacccaccgc gttaccgatg cgggagtgct tggtggggta cgcggacagg acgagcgcga
    17401 ccttcttgtc acggcgctcg atgtgccgca gccgggcgtg ccggacggcg atccccgcga
    17461 cccgggcggc ccgctcgggg tcggcgacat aggcgggcag gccgtcctcg tcgagctcct
    17521 tgaaggagaa cgggacggtg atcagacggc cgtcgaactc gggcacggcg acctgcgtcg
    17581 cggcgtcgag cggggagagg ccctcgtcgt tctcctccca ggcgctgcgc gagccggtca
    17641 ggcacagggc ctgcaggatc ggtacgccca gacccgcgag cgcgccggcg tcccaggact
    17701 cgtcgtcgcc gcccgccgag gcggtggcgg gcttggtgcc gcccgccgcg aggacggtgg
    17761 tgacgaccgc gtccgccgat tccagcgcgg cgatcagctc cggctcgggg gcgcgcaggg
    17821 aggacacgta gagggggagc gcctgggcgt ccttcgcctc gatcgcgtcg cacagggcgt
    17881 gcacgaagga ggtgttcccg ctcatctggt gggcgcggta gtacagcacg gcgatccggg
    17941 ggcccgtggt gctcccgggg gtgcgctcca gcgggcccca ggtgggggcg gcggccggcg
    18001 gctcgaagcc gtggccggtg agcaggacgg tgtccgagag gaagcgcgcc agctggtcca
    18061 ggttggcggg gccgccgtgc gcgaggtagc cgtgcgcctc ggcggcgatg ccgatgggga
    18121 cggtggaggc ctccatcagc tgggcgtccg gggcctgttc gccggtcagt acgaccaccg
    18181 ggcgggtctg ggcgggggcc agcagcaggt cgaggccctc ctgccaggcg cggaggccgc
    18241 cgaggaggcg tacgacgacc aggtcgacac cgtcgaggag accggggagg tcgtcgaggg
    18301 gaaggcggga ggggttcgcg aaccggtacg ggacggggcc gtccgcggcg gcgcgggcgc
    18361 tgagcagatc ggtgtcggac gtcgacagca gcaagatcat gcggcggcag gccttcctcg
    18421 gggtttccgc gccccgggca gtgaggacga cgggagttcc tgactcaccc ggccgatcgc
    18481 tccgcagggt tcacagtggc gggaccgcgc cggattcgca ccgggcttcc tcccatgtcg
    18541 ccgtcctcgg cgatggcgga ccgagcggtc cgccgcaggt catcttaggt gccctgatcc
    18601 ccggccggga gtccgggccg ccccgcggta tcaccggggc cccggcacgg ccggattccg
    18661 ccaggagggc cggaaacatg tggtgaaacg ggggtgaagc ggcgggggcg cgggtggggg
    18721 tgcgggcggg gggcctgcgg tgacgggtgg tggcagggtg gtgacggaca cagaccgggc
    18781 ggggggaatc ctgggtatgc tcgccgccat gccccagtcc ccctccgcca catcgcggga
    18841 cgaacccgtc atacgggacc gcggtgacgc atgccccggc gcgctccggc tgcacgcggc
    18901 ggacgacggg ttcctcgcgc gggtccggct tccgggcggg ctgctcaccg ccgcgcaggc
    18961 cgccgcgctc gcggacgccg ccgagcggtt cggggacggg cacctcgaac tcacctcgcg
    19021 cggaaacgtc cagctccgcg gcctcgccga cggctgcggc ggggccctcg ccgaactcct
    19081 ggactccgtc ggcctgctgc ccgcgccctc gcacgagcgg gtccgcaaca tcgtcgcgag
    19141 ccccctcggg gaccccgctc cggtgcgcgc cctggaccgg ctgctctgcg ccgaccccgg
    19201 cgccgccgct ctctccggcc ggttcctgtt cgccgtggac gacgggcgcg gggacgtcgc
    19261 cgccctcgac cccgacgtgt ccctgctcgc gcgccccggc ggccgggcgc tgatccggct
    19321 cggcgccgcg cccgacgccg ccgaggtggc cgccggcgac ggacccgagg cggcgctgga
    19381 ggccgcccgg cacttcctcg acgccgccgc ccgcgccggc acccgggcct ggcgcgtcgc
    19441 cgagctgccc gccgaacacg ccctggacgc gcgggagttc accgcccggc tggccgccct
    19501 cggcatcccc gcccggtacg tcgcggacgc gccccgcccg tacgcggggc cgcccgcccc
    19561 cggcgtgcac ggggacgcgc tctgcgtcct gatcccgctc ggccggctcc gcagcgccca
    19621 gtggcgggag ctgcccggcg cgctgcggac cacgccctgg cgcagcgtca tcgtcggcga
    19681 caccgccgcc cgccccgccg ggctggtgac cgcgcccggc agtgcctggg agtccgtgac
    19741 cgcctgcacc ggccggcccg gctgcgcgaa agccctcgcg gacgtacgcg ctgacgcgcg
    19801 cgccgtcgcg gaacgggccc gcggaccgct gtccgtccac tggtccggct gcgagcgccg
    19861 ctgcgggcac ccgcgcggca ccgactgggt cgacgccgtc gccaccgcga ccggctaccg
    19921 gctgaccggg cccggcgtgc ccggcggtcc cggcgggccc gcgtcgcggc acgtccccgc
    19981 caccgccccc gaacttggcg cggccctccg ggacgcgcgc aacacccccc gagtgtccga
    20041 agagcagtga agaaatgagc gagtacaccg tgttcgagta cgagaaggac ggcgccgcga
    20101 tctaccgcca gtcctttgcc acgatccgcg ccgaggcgga cctctccggg ctgcccgcct
    20161 ccgtcgccca ggtcgcggtg cgcatgattc acgcctgcgg gatgacggac ctgcccaagg
    20221 acctcggcta caccccggag gtcgtgctgc gggcgcgcgc cgcgctgacc gccggcgccc
    20281 cgatcctgtg cgacgtgcag atggtcgcca gcggcgtcac ccgggggcgg ctccccgccg
    20341 acaacgaggt gatctgcacc ctctccgacc cggccgtacc ggagctcgcc gcgaagatgg
    20401 gcaccacgcg cagcgccgcc gccctcgaag tgtggcgcga ccggggcctg ttggagggct
    20461 cggtgatcgc cgtcggcaac gcgccgaccg cgctgttccg gctgctggag atgatcgagg
    20521 agggcgcccc gcgccccgcc gccgtcatcg gtgtccccgt cggcttcatc ggcgccgccg
    20581 agtccaagga cgccctcgcc gcgcaccctt cgggcctcga ccacctgatc gtgcgcggcc
    20641 ggcgcggcgg cagcgccatc gccgccgccg ccgtcaacgc gatcgcgagc gtggccgaat
    20701 gagcgccgga cgcctgtacg gggtcgggct cggccccggc gacccgtccc tgatgacgct
    20761 gcgggccgtc gaggtcatcg ccgaggcgga cgtcatcgcc taccacagcg cccgccacgg
    20821 ccgctccatc gcccgctcca tcgcggcgaa gcacctgcgc gccgaccacg tcgaggaacc
    20881 gctggtctac ccggtcacca ccgagaccac cgaccacccc ggcggctacc agggggcgat
    20941 ggaggagttc tacgaggact gcgccgcccg cctcgccgcg cacctggacg ccggccggac
    21001 cgtcgccgtg ctcgccgagg gcgacccgct cttctacggc tcgtacatgc acatgcacaa
    21061 gcggctcgcc gaccggtacg aggccgaggt catccccggc gtcacctccg tcagcgccgc
    21121 cgccgcccgc ctcgggaccc cgctggtgga gggcgaggag gtgctgacca tcctgcccgg
    21181 caccctgccg gaggaggagc tcaccgcccg cctcgccgcc accgactcgg ccgtcgtgat
    21241 gaagctcggc cgcaccttcc ccgccgtgcg gcgcgccatg gaggccagcg gccgcctcgc
    21301 cgaggcccgc tacgtggagc gcgccacgat ggcgggcgag cggaccggga tcctcgccga
    21361 caccgacgcc gagaccgtcc cgtacttcgc cgtcgccgtc gtccccagcc ggatcgggaa
    21421 ccccggcagc gtgccctccg ggcccggcgg cgtcgtggtc gtcggcaccg gtccggccgg
    21481 gccgctgtgg ctgacccccg agacccggcg ggcgctggcc gacgccgagg tgctcgtcgg
    21541 gtacacgacg tacctggacc gggtgcccgt gaagccgggc cagatccggc acggctccga
    21601 caacaaggtg gagtccgagc gcgccgagtt cgccctcgac ctcgcccggc gcggcaagcg
    21661 cgtcgccgtg gtctccggcg gtgaccccgg agtcttcgcc atggcgaccg ccgtcctgga
    21721 ggtcgccggg cagccggagt acaaggacgt ccaggtcaag gtcctgccgg gggtgaccgc
    21781 cgccaacgcg gccgccgccg cggccggagc cccgctcggc cacgactacg ccacgatctc
    21841 cctgtccgac cggctcaagc cctgggaggt catcgcggag cggctgcgcg cggccgccgc
    21901 ggccgacctg gtgctggccc tgtacaaccc cggctcccgc agccgcacct ggcaggtcgc
    21961 ccaggccaag gagctcctgc tggagctgcg ttccccgcag accccggtgg tcgtcgcccg
    22021 cgacgtgggc ggccccaccc agacggtgcg cgtcgtcacg ctcgccgaac tggagccggc
    22081 cgaggtggac atgcgcacga tcctgctgat cggctcctcg cagacccagg tcacggaccg
    22141 ccccgacggc acccgtgtca cctggacccc gcgccgctac ccgtgacggc gccggcgcgc
    22201 tgaacgccga aggcccg
//
