LOCUS       NZ_BMUU01000047         2565 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence47, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000047
VERSION     NZ_BMUU01000047.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 2565)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 2565
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000047.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..2565
                     /culture_collection="JCM:4594"
                     /db_xref="taxon:67384"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces xanthochromogenes"
                     /strain="JCM 4594"
                     /submitter_seqid="sequence47"
                     /type_material="type strain of Streptomyces michiganensis"
     gene            <1..>2565
                     /db_xref="GeneID:96295724"
                     /locus_tag="IE233_RS38745"
     region          1..2565
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..2565
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..2565
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:>2565](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..>2565
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             1..>2565
                     /NRPS_PKS="Domain: Condensation_LCL (1-301). E-value:
                     3.8e-114. Score: 372.7. Matches aSDomain:
                     nrpspksdomains_IE233_RS38745_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (471-841). E-value: 2.1e-97.
                     Score: 318.2. Matches aSDomain:
                     nrpspksdomains_IE233_RS38745_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GeneID:96295724"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE233_RS38745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_190029706.1"
                     /sec_met_domain="Condensation (E-value: 1.3e-72, bitscore:
                     230.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1e-80, bitscore:
                     257.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPLSAAQRRLWFLAQMEGPSATYNAPLGLRLRGTLDTPALQAAL
                     SDVVERHEALRTVFPEQDGEPFQQVLLGERAVPLLHVRDCADEHALAAAVKQAEHCVFD
                     LSADLPIRAFLFGAGPQEHVLVLVVHHIATDGWSLAPLMRDVATAYEARCAGTEPQWSA
                     LPVQYADYTLWQQELLGVADDPHSRIAEQVEYWAGALAGVPDQLGLRFDRPRPVEASYR
                     GGRVEWTVEPELHAQLKELAAAHHVTLFMVLQAGLAALLSKLGAGTDVPIGTSVAGRTD
                     VALDDLVGFFINTLVLRTDTSGDPTFAELLDRVRETDLAAFAHQDVPFEQLVEVLNPAR
                     STAHQPLFQIMLVVQNNDEATLELPGLEVTAEPPTYSAEKFDLTVAFAENHAESGAPGG
                     LTAVFSYATDLFDRATIEAMAARLVRLLEAVAADPNRIPGHLDVLSAEERHRLLVEWND
                     TAVEIPQQWAHELFEAQVRRTPTATAVVFEDTEISYEELNTRANRLAHHLIDHGVGPEA
                     IVALALPRSADLVVAILGVLKAGGAYLPIDLDHPQDRIDGLLSDARPVLTLHELPDLAA
                     RPSSNPETPTHPSDPAYVIYTSGSTGKPKGVVVEHAALGAYLIRAREMYPDAAGTALVN
                     SSIAFDLTVTALYTPLVSGGRVILAELDERAGTAGRPSFMKVTPSHLGILENLPEEVSP
                     SGTLILGGEMLTGHALRRMRATHPDLTVIAAYGATETTVNSTEFRISPEHILDPGAVPI
                     GRPFWNTRVYVLDQSLRPVPPGVVGELYVAGSGLARGYLNRAGLTAGRFVANPWGDGER
                     MYRTGDLVFWNHDGQLAYVGRTDNQVKVRGFRIELGEVEAALV"
     aSDomain        4..903
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38745_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.80E-114"
                     /label="IE233_RS38745_Condensation_LCL.1"
                     /locus_tag="IE233_RS38745"
                     /protein_end="301"
                     /protein_start="1"
                     /score="372.7"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIATDG"
                     /tool="antismash"
                     /translation="LPLSAAQRRLWFLAQMEGPSATYNAPLGLRLRGTLDTPALQAALS
                     DVVERHEALRTVFPEQDGEPFQQVLLGERAVPLLHVRDCADEHALAAAVKQAEHCVFDL
                     SADLPIRAFLFGAGPQEHVLVLVVHHIATDGWSLAPLMRDVATAYEARCAGTEPQWSAL
                     PVQYADYTLWQQELLGVADDPHSRIAEQVEYWAGALAGVPDQLGLRFDRPRPVEASYRG
                     GRVEWTVEPELHAQLKELAAAHHVTLFMVLQAGLAALLSKLGAGTDVPIGTSVAGRTDV
                     ALDDLVGFFINTLVLRTDT"
     aSModule        4..2523
                     /domains="nrpspksdomains_IE233_RS38745_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE233_RS38745_AMP-binding.1"
                     /incomplete
                     /locus_tags="IE233_RS38745"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       64..180
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0001"
                     /evalue="3.00E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE233_RS38745"
                     /protein_end="60"
                     /protein_start="21"
                     /score="58.2"
                     /tool="antismash"
                     /translation="ATYNAPLGLRLRGTLDTPALQAALSDVVERHEALRTVFP"
     CDS_motif       385..450
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0002"
                     /evalue="3.30E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE233_RS38745"
                     /protein_end="150"
                     /protein_start="128"
                     /score="35.6"
                     /tool="antismash"
                     /translation="VHHIATDGWSLAPLMRDVATAY"
     CDS_motif       499..537
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0003"
                     /evalue="6.20E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE233_RS38745"
                     /protein_end="179"
                     /protein_start="166"
                     /score="15.6"
                     /tool="antismash"
                     /translation="QYADYTLWQQELL"
     CDS_motif       805..894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0004"
                     /evalue="2.30E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE233_RS38745"
                     /protein_end="298"
                     /protein_start="268"
                     /score="42.5"
                     /tool="antismash"
                     /translation="DVPIGTSVAGRTDVALDDLVGFFINTLVLR"
     CDS_motif       943..1059
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0005"
                     /evalue="8.60E-22"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE233_RS38745"
                     /protein_end="353"
                     /protein_start="314"
                     /score="69.6"
                     /tool="antismash"
                     /translation="RETDLAAFAHQDVPFEQLVEVLNPARSTAHQPLFQIMLV"
     aSDomain        1414..2523
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38745_AMP-binding.1"
                     /evalue="2.10E-97"
                     /label="IE233_RS38745_AMP-binding.1"
                     /locus_tag="IE233_RS38745"
                     /protein_end="841"
                     /protein_start="471"
                     /score="318.2"
                     /specificity="substrate consensus: Asp"
                     /tool="antismash"
                     /translation="FEAQVRRTPTATAVVFEDTEISYEELNTRANRLAHHLIDHGVGPE
                     AIVALALPRSADLVVAILGVLKAGGAYLPIDLDHPQDRIDGLLSDARPVLTLHELPDLA
                     ARPSSNPETPTHPSDPAYVIYTSGSTGKPKGVVVEHAALGAYLIRAREMYPDAAGTALV
                     NSSIAFDLTVTALYTPLVSGGRVILAELDERAGTAGRPSFMKVTPSHLGILENLPEEVS
                     PSGTLILGGEMLTGHALRRMRATHPDLTVIAAYGATETTVNSTEFRISPEHILDPGAVP
                     IGRPFWNTRVYVLDQSLRPVPPGVVGELYVAGSGLARGYLNRAGLTAGRFVANPWGDGE
                     RMYRTGDLVFWNHDGQLAYVGRTDNQVKVR"
     CDS_motif       1600..1641
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0006"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE233_RS38745"
                     /protein_end="547"
                     /protein_start="533"
                     /score="18.5"
                     /tool="antismash"
                     /translation="LGVLKAGGAYLPID"
     CDS_motif       1774..1833
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0007"
                     /evalue="1.20E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="IE233_RS38745"
                     /protein_end="611"
                     /protein_start="591"
                     /score="36.2"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVVVEH"
     CDS_motif       2317..2406
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0008"
                     /evalue="1.30E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS38745"
                     /protein_end="802"
                     /protein_start="772"
                     /score="52.6"
                     /tool="antismash"
                     /translation="PPGVVGELYVAGSGLARGYLNRAGLTAGRF"
     CDS_motif       2488..2553
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38745_0009"
                     /evalue="5.50E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE233_RS38745"
                     /protein_end="851"
                     /protein_start="829"
                     /score="37.6"
                     /tool="antismash"
                     /translation="YVGRTDNQVKVRGFRIELGEVE"
ORIGIN
        1 ctgttgccgt tgtcggccgc gcagcgcagg ctgtggttcc tcgcccagat ggagggaccg
       61 agcgcgacgt acaacgcgcc gctcggtctg cggttgcggg gcacgctgga cacccccgcg
      121 ctgcaggcgg cgctgtccga tgtggtggag cggcacgagg ccctgcgcac cgtgttcccc
      181 gagcaggacg gcgaaccctt ccagcaggtg cttctcggcg agcgggccgt tcctctgctg
      241 catgtgcggg actgcgccga cgagcatgcg ttggccgccg cggtgaagca ggccgagcac
      301 tgcgttttcg atctgtcggc cgacctgccg atccgagcct tcctgttcgg cgccggcccg
      361 caggagcacg tactcgtgct ggtggttcac cacatcgcca ccgacggctg gtccctggcc
      421 ccgttgatgc gtgacgtggc gactgcctac gaggcccggt gcgcgggtac ggagcctcag
      481 tggtccgccc tgccggtcca gtacgccgac tacaccttgt ggcagcagga gctgctgggt
      541 gtcgctgacg acccccacag ccggatcgcc gagcaggtgg agtattgggc cggcgccctg
      601 gcgggagtgc cggatcagct ggggctgcgt ttcgaccggc cgcgtccggt cgaggccagc
      661 taccggggcg gccgcgtgga atggaccgtc gagccggaac tccacgcaca actcaaggag
      721 ttggccgcgg cccaccacgt cacgctgttc atggtcctgc aagccgggct ggccgcgctg
      781 ctgagcaagc tgggtgccgg cacggacgtt ccgatcggga cctcggtcgc cggccgcacc
      841 gacgtggcgc tcgacgacct ggtggggttc ttcatcaaca ccctggtgct gcgcaccgac
      901 acctcgggcg acccgacctt cgccgagctc ctggaccggg tccgcgagac cgacttggcc
      961 gcgttcgccc accaggacgt ccccttcgag cagctcgtgg aggtgctcaa cccggccagg
     1021 tcgactgccc atcagccgct gttccagatc atgctggtgg tgcagaacaa cgacgaggcc
     1081 accctcgaac tgcccggcct ggaggtgacc gcggaacctc ccacctacag cgccgagaag
     1141 ttcgacctca ccgtcgcctt cgccgagaac cacgccgaat ccggcgcccc cggcgggctc
     1201 accgctgtct tcagctacgc cacggacctg ttcgaccggg ccacgatcga ggcgatggcc
     1261 gcccggctgg tccgcctgct ggaggcggtg gccgccgacc cgaaccggat acccggccac
     1321 ctcgatgtgc tctccgccga ggagcggcac aggctcctgg tggagtggaa cgacaccgcg
     1381 gtcgagattc cacagcagtg ggcccacgaa ctgttcgaag cccaggtgcg ccgcactccc
     1441 acggccaccg ccgtggtctt cgaggacacc gagatctcct acgaagaact caacacacgc
     1501 gccaaccgtc tggcacacca cctcatcgac cacggagtgg gcccggaagc cattgtggcc
     1561 ctggccctac cgcgctccgc cgacctcgtc gtcgcgatcc tcggtgtgct gaaagccggc
     1621 ggagcctacc tgccgatcga tctcgatcac ccgcaggacc gcatcgacgg cctcctcagc
     1681 gatgcgcgcc cggtgctcac cctccacgag ctgcccgatc tggccgcccg tccgtcgagc
     1741 aacccggaga cacccacaca tccgtccgac cccgcatacg tcatctacac ctccggctcc
     1801 accgggaagc ccaagggcgt ggtggtagaa cacgccgctc tgggtgccta tttgatccgg
     1861 gcgcgagaga tgtaccccga cgcggccggt acggcgttgg tgaattcctc catcgctttc
     1921 gacctgacgg tcaccgcgct ttacacaccc ttggtgagtg gagggcgggt gatcctggcc
     1981 gaactggacg aacgcgccgg gacggccggc cggccctcgt tcatgaaagt caccccgtcc
     2041 cacctcggga tactcgagaa ccttccggag gaagtctccc cgtccggaac gctgatcctc
     2101 ggcggggaaa tgctgaccgg tcatgcactg cgacggatgc gcgcgacgca tccggacctg
     2161 accgtgatcg ccgcctacgg ggcgaccgaa accacggtca acagcaccga gttccgtatc
     2221 tccccggagc acattctcga tccgggcgcc gtgcccatcg gccgcccctt ctggaacacg
     2281 cgcgtctatg ttctggatca gtcgttgcgg cccgtgccac ccggcgtggt gggagagctg
     2341 tacgtggcgg gttcgggtct ggcccgcggc tacctcaacc gggccggcct gaccgctggg
     2401 cgcttcgtcg ccaacccctg gggcgacggc gagcggatgt atcgcaccgg tgacctcgtg
     2461 ttctggaacc acgacgggca gctggcctac gtcggccgca cggacaacca ggtgaaggtg
     2521 cggggtttcc gtatcgagtt gggtgaggtc gaggcggcgc tggtg
//
