LOCUS       NZ_BMUU01000044         3029 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence44, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000044
VERSION     NZ_BMUU01000044.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 3029)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 3029
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000044.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..3029
                     /culture_collection="JCM:4594"
                     /db_xref="taxon:67384"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces xanthochromogenes"
                     /strain="JCM 4594"
                     /submitter_seqid="sequence44"
                     /type_material="type strain of Streptomyces michiganensis"
     region          1..3029
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..3029
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..3029
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[438:>3029](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      439..>3029
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            40..>285
                     /db_xref="GeneID:96295900"
                     /locus_tag="IE233_RS39985"
                     /pseudo=""
     CDS             40..>285
                     /codon_start=1
                     /db_xref="GeneID:96295900"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE233_RS39985"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLTVGDTTVSEPELGGLTAQFVTPEIRVAKFDLTFAFGERRAADG
                     SPDGLDITVEYATDLYDPATAEAVAARLVRLLTAAVT"
     misc_feature    complement(290..305)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    343..358
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.75"
                     /tool="antismash"
     gene            439..>3029
                     /db_xref="GeneID:96295721"
                     /locus_tag="IE233_RS38730"
     CDS             439..>3029
                     /NRPS_PKS="Domain: AMP-binding (1-384). E-value: 9.6e-96.
                     Score: 312.8. Matches aSDomain:
                     nrpspksdomains_IE233_RS38730_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (488-556). E-value: 4.9e-26. Score:
                     82.7. Matches aSDomain: nrpspksdomains_IE233_RS38730_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (572-864). E-value:
                     2e-115. Score: 376.9. Matches aSDomain:
                     nrpspksdomains_IE233_RS38730_Condensation_LCL.1"
                     /codon_start=1
                     /db_xref="GeneID:96295721"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="IE233_RS38730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_229893143.1"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-110, bitscore:
                     355.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.9e-18, bitscore:
                     54.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 6.2e-74, bitscore:
                     235.8, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFEDQVVSYGELEVWSNRLARYLSGKGVRPGDLVAVHVERSPYM
                     VAAILAVLKAGAGYTMLDPQFPQERLNAVLGQVRPAVVVTQSHLPVLRSDAVRVDLTRE
                     VAEISAVSGAGLATGGSPESVACVMFTSGSTGVPKGVAASHRALAATFVGPDYLAFGPE
                     QTFLQCSPVSWDAFALEVFGPLLHGGVCVLQPGQHTDPHQIVELVERHQVTTLQMSASL
                     FNHMLDEHPAVFGQIREAMTAGEAASPAHVARALEAYPHLRLLNGYGPAESMGFTTTFA
                     IEPGMAEGVASIPVGGPLSGKHAYVLDANLELVAPGVPGELYVAGHGLAHGYIGQPGLS
                     ADRFVANPYGPAGARMYRTGDLARWNKQGALEYLGRGDQQIKLRGFRIEPGEIEAALAS
                     HPQVQQAAAVVREDRPGDKRLVAYVVGEGVDSAALVRHTAARLPEYMVPAAVVVLEELP
                     RTVNGKLDRRALPAPDLSAVSDGRAPRNPAEEILCGLFADTLGLPSVTIDDHFFHRGGH
                     SLLATRLTSKIRQAFGVRLGVREIFQYPTVGRLAELIAAGTGADERPALVAGGRPERPP
                     LSSAQQRLWFLDQLEGPSPTYNIPLGVRLTGALDIEALRRALVDVVGRHEALRTTFPSE
                     QGRPHQAVRSLAETDLALPVTPVTEESLHQALARLAGVTFDLATDLPIRADLLALSPEE
                     HVLLVVMHHIASDGWSNGPLLRDLATAYEARTRDAAPDWEPLPVQYADYSLWQRSLLAT
                     EEERQLDFWQSQLAGLPEEATLPADRPRAAVASYRGATHKVSAPAVTHAALTGLARETG
                     TTLFMVAQAAVASVLSRCGAGVDVPIGSPVAGRTDEALDDLVGFFVNTLVLR"
     aSDomain        442..1590
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38730_AMP-binding.1"
                     /evalue="9.60E-96"
                     /label="IE233_RS38730_AMP-binding.1"
                     /locus_tag="IE233_RS38730"
                     /protein_end="384"
                     /protein_start="1"
                     /score="312.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VFEDQVVSYGELEVWSNRLARYLSGKGVRPGDLVAVHVERSPYMV
                     AAILAVLKAGAGYTMLDPQFPQERLNAVLGQVRPAVVVTQSHLPVLRSDAVRVDLTREV
                     AEISAVSGAGLATGGSPESVACVMFTSGSTGVPKGVAASHRALAATFVGPDYLAFGPEQ
                     TFLQCSPVSWDAFALEVFGPLLHGGVCVLQPGQHTDPHQIVELVERHQVTTLQMSASLF
                     NHMLDEHPAVFGQIREAMTAGEAASPAHVARALEAYPHLRLLNGYGPAESMGFTTTFAI
                     EPGMAEGVASIPVGGPLSGKHAYVLDANLELVAPGVPGELYVAGHGLAHGYIGQPGLSA
                     DRFVANPYGPAGARMYRTGDLARWNKQGALEYLGRGDQQIKLR"
     aSModule        442..2106
                     /complete
                     /domains="nrpspksdomains_IE233_RS38730_AMP-binding.1"
                     /domains="nrpspksdomains_IE233_RS38730_PCP.1"
                     /locus_tags="IE233_RS38730"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       586..627
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0001"
                     /evalue="1.80E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="IE233_RS38730"
                     /protein_end="63"
                     /protein_start="49"
                     /score="11.8"
                     /tool="antismash"
                     /translation="LAVLKAGAGYTMLD"
     CDS_motif       814..873
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0002"
                     /evalue="4.40E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IE233_RS38730"
                     /protein_end="145"
                     /protein_start="125"
                     /score="28.4"
                     /tool="antismash"
                     /translation="ACVMFTSGSTGVPKGVAASH"
     CDS_motif       1384..1470
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0003"
                     /evalue="4.30E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS38730"
                     /protein_end="344"
                     /protein_start="315"
                     /score="44.6"
                     /tool="antismash"
                     /translation="PGVPGELYVAGHGLAHGYIGQPGLSADRF"
     CDS_motif       1519..1542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0004"
                     /evalue="3.10E+01"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE233_RS38730"
                     /protein_end="368"
                     /protein_start="360"
                     /score="-1.9"
                     /tool="antismash"
                     /translation="DLARWNKQ"
     CDS_motif       1555..1620
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0005"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE233_RS38730"
                     /protein_end="394"
                     /protein_start="372"
                     /score="36.2"
                     /tool="antismash"
                     /translation="YLGRGDQQIKLRGFRIEPGEIE"
     aSDomain        1903..2106
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38730_PCP.1"
                     /evalue="4.90E-26"
                     /label="IE233_RS38730_PCP.1"
                     /locus_tag="IE233_RS38730"
                     /protein_end="556"
                     /protein_start="488"
                     /score="82.7"
                     /tool="antismash"
                     /translation="EEILCGLFADTLGLPSVTIDDHFFHRGGHSLLATRLTSKIRQAFG
                     VRLGVREIFQYPTVGRLAELIAA"
     aSDomain        2155..>3029
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38730_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.00E-115"
                     /label="IE233_RS38730_Condensation_LCL.1"
                     /locus_tag="IE233_RS38730"
                     /protein_end="864"
                     /protein_start="572"
                     /score="376.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIASDG"
                     /tool="antismash"
                     /translation="ERPPLSSAQQRLWFLDQLEGPSPTYNIPLGVRLTGALDIEALRRA
                     LVDVVGRHEALRTTFPSEQGRPHQAVRSLAETDLALPVTPVTEESLHQALARLAGVTFD
                     LATDLPIRADLLALSPEEHVLLVVMHHIASDGWSNGPLLRDLATAYEARTRDAAPDWEP
                     LPVQYADYSLWQRSLLATEEERQLDFWQSQLAGLPEEATLPADRPRAAVASYRGATHKV
                     SAPAVTHAALTGLARETGTTLFMVAQAAVASVLSRCGAGVDVPIGSPVAGRTDEALDDL
                     VGFFVNTLVLR"
     CDS_motif       2170..2202
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0006"
                     /evalue="4.60E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE233_RS38730"
                     /protein_end="588"
                     /protein_start="577"
                     /score="9.6"
                     /tool="antismash"
                     /translation="SSAQQRLWFLD"
     CDS_motif       2221..2337
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0007"
                     /evalue="7.90E-20"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE233_RS38730"
                     /protein_end="633"
                     /protein_start="594"
                     /score="63.3"
                     /tool="antismash"
                     /translation="PTYNIPLGVRLTGALDIEALRRALVDVVGRHEALRTTFP"
     CDS_motif       2539..2604
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0008"
                     /evalue="8.30E-12"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE233_RS38730"
                     /protein_end="722"
                     /protein_start="700"
                     /score="37.5"
                     /tool="antismash"
                     /translation="MHHIASDGWSNGPLLRDLATAY"
     CDS_motif       2653..2691
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0009"
                     /evalue="8.20E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE233_RS38730"
                     /protein_end="751"
                     /protein_start="738"
                     /score="18.3"
                     /tool="antismash"
                     /translation="QYADYSLWQRSLL"
     CDS_motif       2839..2874
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0010"
                     /evalue="2.00E+01"
                     /label="C3_dual_135-156"
                     /locus_tag="IE233_RS38730"
                     /protein_end="812"
                     /protein_start="800"
                     /score="-1.3"
                     /tool="antismash"
                     /translation="HAALTGLARETG"
     CDS_motif       2941..>3029
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38730_0011"
                     /evalue="1.00E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE233_RS38730"
                     /protein_end="864"
                     /protein_start="834"
                     /score="50.0"
                     /tool="antismash"
                     /translation="DVPIGSPVAGRTDEALDDLVGFFVNTLVLR"
ORIGIN
        1 cccgagcgtt cggcgtcccg gcatccgttg ttccaggtca tgctcaccgt cggcgacacg
       61 acggtgagcg aacctgaact cggcggtctg acagcacagt tcgtcactcc cgagatccgc
      121 gtcgcgaagt tcgacctgac cttcgcgttc ggtgagcgcc gggccgccga cggcagcccg
      181 gacggtctcg acatcacggt ggagtacgcc accgacctct acgaccctgc caccgcggag
      241 gccgtcgccg ctcgcctggt acgtctcctc accgccgctg tcaccacccc cgaccagccg
      301 gtctccaccc tgtccctcct caccgaggac gagcacaccc gcctcaccga ctggtcaggg
      361 cccgccactg cggcgccccg gctcggtctg gacggcttgt tcgcgggtca ggcggcgcgt
      421 tcgccggagg ctccggctgt ggtgtttgag gatcaggtgg tgtcgtacgg ggagttggag
      481 gtgtggtcga accgtctggc gcggtatctg tcgggcaagg gtgtgcggcc gggtgatctg
      541 gtggcggtgc atgtggagcg ttcgccgtac atggtggcgg cgatcctggc ggtgttgaag
      601 gcgggtgcgg gttacacgat gttggatccg cagtttccgc aggagcgtct gaatgctgtt
      661 ctggggcagg tgcgtccggc tgttgttgtc acgcagtcgc atcttccggt gttgcggtcg
      721 gatgcggtgc gtgttgatct gacgcgtgag gtggcggaga tcagtgccgt ctcgggtgcg
      781 ggactggcga cgggtgggtc tccggagtcg gttgcgtgcg tgatgttcac gtccggttcg
      841 acgggtgtgc cgaagggtgt tgccgcctca caccgggcgc ttgcggcgac gtttgtcggc
      901 cctgactatc tggcgttcgg tccggagcag acgttcttgc agtgctctcc ggtgtcgtgg
      961 gacgcgttcg cgctggaggt cttcgggccg ctgcttcatg gtggggtgtg tgtgcttcag
     1021 ccgggtcagc acactgatcc gcatcagatc gtggagctgg tggaacggca tcaggtgacg
     1081 acgctgcaga tgtcggcgag tctgttcaac cacatgctgg acgaacaccc cgccgtcttc
     1141 ggccagatca gagaggcgat gaccgcgggc gaggcggcct caccggcgca tgtcgcccgc
     1201 gccctggagg cctatccgca cttgcggttg ctgaacgggt acgggccggc ggagagcatg
     1261 ggcttcacga ccacgttcgc cattgagccg ggtatggccg agggggtggc gagcattccg
     1321 gtgggtggtc cgctgtccgg gaagcatgcc tatgtgctcg atgcgaacct ggagttggtg
     1381 gcacctggcg tgccgggtga gttgtatgtc gccgggcatg gtctcgcgca tggctatatc
     1441 gggcagcccg gtttgtcggc ggaccgtttc gtggccaacc cttacggacc tgctggggcg
     1501 cggatgtatc gcacggggga cttggcgcgt tggaacaagc agggtgcgct ggagtatctc
     1561 ggccggggtg atcagcagat caagctgcgg ggtttccgga tcgaaccggg ggagatcgag
     1621 gcggcgttgg cctcgcatcc gcaggtgcag caggcggcgg cggtggtccg tgaggaccgc
     1681 cctggtgaca agcgcctggt cgcctatgtg gtgggtgagg gtgtcgacag tgcggctctg
     1741 gtgcgccaca ccgcggcgcg gctgccggag tacatggtcc ctgcggccgt cgtggtcctg
     1801 gaggagttgc ctcgtacggt gaacggcaag ctcgaccgcc gtgccttgcc cgccccggat
     1861 ctgtccgccg tctccgacgg ccgtgccccg cggaatccgg ccgaggagat cctgtgcggt
     1921 ctcttcgccg acaccctcgg gctcccttcc gtcaccatcg acgaccactt cttccaccgc
     1981 ggcggccact ccctgctcgc cacccggctc acctcgaaga tccggcaggc cttcggcgta
     2041 cggctcgggg tgcgggagat cttccagtac ccgacggtcg gacggctggc cgagctgatc
     2101 gcggcgggca ccggcgcgga cgagcgtccg gcgctggtgg cgggggggcg gcccgaacgg
     2161 ccgccgctct cctccgccca gcaacggctc tggttcctgg accagttgga ggggccctca
     2221 ccgacgtaca acattccgct gggcgtacgg ctcaccggtg cgctcgacat cgaggcgctg
     2281 cgccgcgcgc tggtcgacgt ggtcggccgg cacgaagccc tgcggaccac attcccctcg
     2341 gagcagggcc ggcctcacca ggccgtccgc tccctcgcag agaccgacct cgcgctcccg
     2401 gtgaccccgg tgacggagga gtccctgcac caggcgctgg cccggctggc cggcgtcacc
     2461 ttcgacctcg ccaccgatct gcccatccgc gcggatctgc tggcgctgtc ccccgaggag
     2521 cacgtgctcc tggtggtgat gcaccacatc gcctccgacg gctggtcgaa cggcccgctc
     2581 ctgcgggacc tcgccacggc gtacgaggcg cgcacgcggg acgcggcccc cgactgggag
     2641 ccgctgcccg tccagtacgc cgactacagc ctgtggcagc gcagtctcct cgccaccgaa
     2701 gaggagcgcc aactcgactt ctggcagtcg cagttggccg ggttgccgga ggaggcgacg
     2761 ttgccggccg atcggccgcg tgctgctgtc gcttcttatc gcggggccac tcacaaggtg
     2821 tccgcccctg ctgtcacgca tgctgctctg accgggttgg cgcgtgagac cggtaccacg
     2881 ttgttcatgg ttgctcaggc ggctgtggcg tccgtgcttt cgcggtgtgg tgcgggtgtt
     2941 gatgtcccga tcggttcgcc ggtcgcgggc cgtacggacg aggctctcga tgatctcgtg
     3001 gggttcttcg tcaatacgtt ggttctgcg
//
