LOCUS       NZ_BMUU01000038         7717 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence38, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000038
VERSION     NZ_BMUU01000038.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 7717)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7717
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000038.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     gene            <1..3660
                     /db_xref="GeneID:96295702"
                     /locus_tag="IE233_RS38635"
     CDS             <1..3660
                     /NRPS_PKS="Domain: PCP (86-154). E-value: 3.6e-27. Score:
                     86.4. Matches aSDomain: nrpspksdomains_IE233_RS38635_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (170-466). E-value:
                     3e-117. Score: 382.8. Matches aSDomain:
                     nrpspksdomains_IE233_RS38635_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (635-1029). E-value:
                     1.5e-110. Score: 361.6. Matches aSDomain:
                     nrpspksdomains_IE233_RS38635_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1133-1202). E-value: 9.9e-28.
                     Score: 88.1. Matches aSDomain:
                     nrpspksdomains_IE233_RS38635_PCP.2"
                     /codon_start=1
                     /db_xref="GeneID:96295702"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE233_RS38635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_190029694.1"
                     /sec_met_domain="Condensation (E-value: 1.9e-78, bitscore:
                     250.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-121, bitscore:
                     392.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4e-19, bitscore:
                     56.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AAVVVREDRPGDKRLVAYVVADGDTRVDTEALRRYAGTALPEYMV
                     PAAFVELDLLPLTANGKLDRRALPEPRLGTGPGGRQGRTPVEEVLCGLFADALGLPAVS
                     IDDDFFRLGGHSLLATRLVSRVRRTLGARLSVRDLFRWPTVARIAAFIADGTDADRRPA
                     LVAGERPERIPLSAAQRRLWFLDQMEGPSATYNIPLAVRLVGTLDTDALHLALGDVVAR
                     HEALRTVFPAEQGTPYQQVLPADRARPAPALIPATREALPELLRDLSATTFDLARELPL
                     RADLLRVEDDEHVLLLVIHHIASDGWSTTPLVRDLAAAYTARAEGTAPSWEPLPVQYAD
                     YALWQQALLAADEERQLDHWRRVLDGLPEEVTLPADRARPATASYRGASLTVRCPAGLH
                     ASLTRLARESGTTLFMVAQAATSALLARSGAGSDIPIGSPVAGRSEEALEELVGFFVNT
                     LVLRTDVSGNPTFRELLDRVRTTDLAAWAHQDVPFDRLVEALNPERSAARHPLFQVMLS
                     VTDADTPVPQLPGLQAESEFTALGIAKFDLTFTFHEHRAPDGGPAGLGITVEYATDLYD
                     PATVSAVAARLVRLLQAAADTPDAPIGALDVLADDERARLLDTWHGTRQVRPAAALPEL
                     FAGQAARTPDAVALSHGEQRLTYAELDRRANLLAHRLIAEGVRPGSRVALFQERSPEAV
                     VAILAVVKAGAVYVPLDTRYPKDRVDLIVRVSGAEVFLTDRDLTGFALPDGARVLSVTG
                     PAGSYADTAPEVTVHPDQLAYVMFTSGSTGVPKGVAVTHRNITELAADDRFTGAAHRRV
                     LLHSPLAFDATTYELWVPLLSGGTLVVAPPGLLDTAALTRILAEESITGLWLTAGLFRL
                     VAEEDPAAFAGLREVWTGGDVVPPEAVRRVMDACPDLQVVNGYGPTETTTFASAHPLHR
                     PFDYAGALPIGRPLDNTRLYVLDEHLELVAPGVPGELYIAGTGLAQGYLDRPGLTAERF
                     VADPYGPPGVRMYRTGDLVRWSRDGEVEYLGRADQQVKLRGFRIEPGEIESALVAHPSV
                     AQAAVVVREDRPGDKRLVAYVVGEGVDLDALRTDASEALPDYMVPAVFMALDALPLTAN
                     GKLDKRALPRPPVVAGSGGRAPRNPREEVLCGLFAEVLGVPSVSVDDDFFRLGGHSLLA
                     TRLISRIRTVLGAELPVPALFENPNVARLAERLDRAESARPKLRPMRRMGASQ"
     source          1..7717
                     /culture_collection="JCM:4594"
                     /db_xref="taxon:67384"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces xanthochromogenes"
                     /strain="JCM 4594"
                     /submitter_seqid="sequence38"
                     /type_material="type strain of Streptomyces michiganensis"
     region          1..7717
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..7717
                     /SMILES="NC(C(C)C)C(=O)NC(C(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7717
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:>7717](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <1..>7717
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS_motif       184..210
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0001"
                     /evalue="8.30E-02"
                     /label="NRPS-A_a10"
                     /locus_tag="IE233_RS38635"
                     /protein_end="69"
                     /protein_start="60"
                     /score="5.9"
                     /tool="antismash"
                     /translation="GKLDRRALP"
     aSDomain        262..465
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38635_PCP.1"
                     /evalue="3.60E-27"
                     /label="IE233_RS38635_PCP.1"
                     /locus_tag="IE233_RS38635"
                     /protein_end="154"
                     /protein_start="86"
                     /score="86.4"
                     /tool="antismash"
                     /translation="EEVLCGLFADALGLPAVSIDDDFFRLGGHSLLATRLVSRVRRTLG
                     ARLSVRDLFRWPTVARIAAFIAD"
     CDS_motif       268..300
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0002"
                     /evalue="2.30E+00"
                     /label="Cy4"
                     /locus_tag="IE233_RS38635"
                     /protein_end="99"
                     /protein_start="88"
                     /score="1.7"
                     /tool="antismash"
                     /translation="VLCGLFADALG"
     aSDomain        514..1401
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38635_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.00E-117"
                     /label="IE233_RS38635_Condensation_LCL.1"
                     /locus_tag="IE233_RS38635"
                     /protein_end="466"
                     /protein_start="170"
                     /score="382.8"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIASDG"
                     /tool="antismash"
                     /translation="ERIPLSAAQRRLWFLDQMEGPSATYNIPLAVRLVGTLDTDALHLA
                     LGDVVARHEALRTVFPAEQGTPYQQVLPADRARPAPALIPATREALPELLRDLSATTFD
                     LARELPLRADLLRVEDDEHVLLLVIHHIASDGWSTTPLVRDLAAAYTARAEGTAPSWEP
                     LPVQYADYALWQQALLAADEERQLDHWRRVLDGLPEEVTLPADRARPATASYRGASLTV
                     RCPAGLHASLTRLARESGTTLFMVAQAATSALLARSGAGSDIPIGSPVAGRSEEALEEL
                     VGFFVNTLVLRTDVS"
     aSModule        514..3609
                     /complete
                     /domains="nrpspksdomains_IE233_RS38635_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE233_RS38635_AMP-binding.1"
                     /domains="nrpspksdomains_IE233_RS38635_PCP.2"
                     /locus_tags="IE233_RS38635"
                     /monomer_pairings="Val -> Val"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       580..696
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0003"
                     /evalue="1.60E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE233_RS38635"
                     /protein_end="231"
                     /protein_start="192"
                     /score="59.1"
                     /tool="antismash"
                     /translation="ATYNIPLAVRLVGTLDTDALHLALGDVVARHEALRTVFP"
     CDS_motif       898..963
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0004"
                     /evalue="3.50E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE233_RS38635"
                     /protein_end="320"
                     /protein_start="298"
                     /score="35.5"
                     /tool="antismash"
                     /translation="IHHIASDGWSTTPLVRDLAAAY"
     CDS_motif       1012..1050
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0005"
                     /evalue="7.80E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE233_RS38635"
                     /protein_end="349"
                     /protein_start="336"
                     /score="15.3"
                     /tool="antismash"
                     /translation="QYADYALWQQALL"
     CDS_motif       1039..1101
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0006"
                     /evalue="4.00E+01"
                     /label="C2_dual_024-063"
                     /locus_tag="IE233_RS38635"
                     /protein_end="366"
                     /protein_start="345"
                     /score="-3.1"
                     /tool="antismash"
                     /translation="QALLAADEERQLDHWRRVLDG"
     CDS_motif       1300..1389
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0007"
                     /evalue="2.20E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE233_RS38635"
                     /protein_end="462"
                     /protein_start="432"
                     /score="49.0"
                     /tool="antismash"
                     /translation="DIPIGSPVAGRSEEALEELVGFFVNTLVLR"
     CDS_motif       1438..1554
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0008"
                     /evalue="3.60E-23"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE233_RS38635"
                     /protein_end="517"
                     /protein_start="478"
                     /score="74.0"
                     /tool="antismash"
                     /translation="RTTDLAAWAHQDVPFDRLVEALNPERSAARHPLFQVMLS"
     aSDomain        1909..3090
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38635_AMP-binding.1"
                     /evalue="1.50E-110"
                     /label="IE233_RS38635_AMP-binding.1"
                     /locus_tag="IE233_RS38635"
                     /protein_end="1029"
                     /protein_start="635"
                     /score="361.6"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FAGQAARTPDAVALSHGEQRLTYAELDRRANLLAHRLIAEGVRPG
                     SRVALFQERSPEAVVAILAVVKAGAVYVPLDTRYPKDRVDLIVRVSGAEVFLTDRDLTG
                     FALPDGARVLSVTGPAGSYADTAPEVTVHPDQLAYVMFTSGSTGVPKGVAVTHRNITEL
                     AADDRFTGAAHRRVLLHSPLAFDATTYELWVPLLSGGTLVVAPPGLLDTAALTRILAEE
                     SITGLWLTAGLFRLVAEEDPAAFAGLREVWTGGDVVPPEAVRRVMDACPDLQVVNGYGP
                     TETTTFASAHPLHRPFDYAGALPIGRPLDNTRLYVLDEHLELVAPGVPGELYIAGTGLA
                     QGYLDRPGLTAERFVADPYGPPGVRMYRTGDLVRWSRDGEVEYLGRADQQVKLR"
     CDS_motif       2095..2136
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0009"
                     /evalue="2.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE233_RS38635"
                     /protein_end="711"
                     /protein_start="697"
                     /score="17.3"
                     /tool="antismash"
                     /translation="LAVVKAGAVYVPLD"
     CDS_motif       2320..2379
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0010"
                     /evalue="3.90E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE233_RS38635"
                     /protein_end="792"
                     /protein_start="772"
                     /score="31.6"
                     /tool="antismash"
                     /translation="AYVMFTSGSTGVPKGVAVTH"
     CDS_motif       2884..2970
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0011"
                     /evalue="2.10E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS38635"
                     /protein_end="989"
                     /protein_start="960"
                     /score="52.0"
                     /tool="antismash"
                     /translation="PGVPGELYIAGTGLAQGYLDRPGLTAERF"
     CDS_motif       3055..3120
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0012"
                     /evalue="2.60E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE233_RS38635"
                     /protein_end="1039"
                     /protein_start="1017"
                     /score="38.6"
                     /tool="antismash"
                     /translation="YLGRADQQVKLRGFRIEPGEIE"
     CDS_motif       3325..3351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0013"
                     /evalue="9.50E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="IE233_RS38635"
                     /protein_end="1116"
                     /protein_start="1107"
                     /score="3.1"
                     /tool="antismash"
                     /translation="GKLDKRALP"
     aSDomain        3403..3609
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38635_PCP.2"
                     /evalue="9.90E-28"
                     /label="IE233_RS38635_PCP.2"
                     /locus_tag="IE233_RS38635"
                     /protein_end="1202"
                     /protein_start="1133"
                     /score="88.1"
                     /tool="antismash"
                     /translation="EEVLCGLFAEVLGVPSVSVDDDFFRLGGHSLLATRLISRIRTVLG
                     AELPVPALFENPNVARLAERLDRA"
     CDS_motif       3409..3441
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38635_0014"
                     /evalue="3.60E-02"
                     /label="Cy4"
                     /locus_tag="IE233_RS38635"
                     /protein_end="1146"
                     /protein_start="1135"
                     /score="7.3"
                     /tool="antismash"
                     /translation="VLCGLFAEVLG"
     gene            3657..>7717
                     /db_xref="GeneID:96295703"
                     /locus_tag="IE233_RS38640"
     CDS             3657..>7717
                     /NRPS_PKS="Domain: Condensation_LCL (1-300). E-value:
                     8e-116. Score: 378.2. Matches aSDomain:
                     nrpspksdomains_IE233_RS38640_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (472-874). E-value: 6e-104.
                     Score: 339.8. Matches aSDomain:
                     nrpspksdomains_IE233_RS38640_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (978-1047). E-value: 2.1e-27. Score:
                     87.1. Matches aSDomain: nrpspksdomains_IE233_RS38640_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1062-1354). E-value:
                     9.3e-114. Score: 371.4. Matches aSDomain:
                     nrpspksdomains_IE233_RS38640_Condensation_LCL.2"
                     /codon_start=1
                     /db_xref="GeneID:96295703"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE233_RS38640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_190029695.1"
                     /sec_met_domain="Condensation (E-value: 4.6e-74, bitscore:
                     236.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.2e-116, bitscore:
                     374.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-19, bitscore:
                     57.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPLSYAQQRLWFLAQLEGPSATYNIPLALRLSGDLDTEALTLAL
                     ADVVARHESLRTVYPEREGTPYQHILPAEDARPELPVLAADEDTLADVLAAESAHVFGL
                     AADLPVQARLIRLGEREHVLLVVMHHIASDGWSIAPLLRDLAHAYGARRAGHAPQQEPL
                     EIQYADYTLWQQEVLGEPDADDSLMNRQLAYWQDKLAGFPEEATLPADRPRPAVASYRG
                     DTVTVHCPPGTHTALADLARESGATLFMAAQAALATVLAVSGAGPDVPIGSPVAGRTDE
                     ALDDLVGFFVNTLVLRTDVAGDPTFRELLGRVRETDLGAWAHQDLPFDRLVEALNPERS
                     GARHPLFQVMLTLVQAGSTDPGTDFPGLRTRAEYSATRTAKFDLTVGFDEHLTPDGLPA
                     GLDITAEYATDLYDPETVEALLGRLLRLLGEAAAHPDTPLSGLDLLDPAERTLLLDTWT
                     GRATPVPDASLAALFAAQAARTPDAVALTHAGRSWTYAEADAVSSRFAHRLAGLGVGPE
                     TVVAVLMERSADLVLALLAIVKAGGVYAPLNAVDPASRLTRILADTAAPLLLVDRNLAD
                     HELVTEAGDTRVLLVDDLTADTETAAYPATAPEVAAHPDQWLYVMFTSGSTGVPKGVAV
                     THRNVTELALDHRWRRAAHQRVLFHSPHTFDASTFELWAPWLTGGTVAVAPAGVLDTAA
                     LAAVLAEESITGLWLTAGLFRLVAEEDPAAFTGLGEVWTGGDVVPPEAVRRVMDACPDL
                     QVVNGYGPTETTTFASAHPVRRPFDYAGALPIGRPLDNTRLYVLDDHLGLVAPGVPGEL
                     YIAGAGLARGYLRRPAQTAERFVADPHGPAGTRMYRTGDLVRWSRDGEIEYLGRADQQV
                     KLRGFRIEPGEIESALVAHPSVAQAAVVVREDRPGDKRLVAYVVGEHVDTAALRRHASE
                     ALPDYMVPAAFVLLDTLPLTGNGKLDRRALPAPDLSSDSTGRAPRDPAEEVLCGLFADV
                     LGRPSVTIDDHFLRLGGHSLLATRLVSRIRTAFGVRITVRDMFQHPTVAQLNELIQTSK
                     GDKARPALVAGVRPARLPLSSAQQRLWFLDQLEGPSPTYNIPIALRLAGPLDVDALRRA
                     LTDVVGRHEALRTVFRVADGEAYQLVLAAAEIDVPLPVVPADEATLPALLAEESAKAFD
                     LTAQLPLRAALLQVTGEDHVLVVVTHHIASDGWSNAPFFADLDRAYAARTEGTAPGWEP
                     LPVQYADYTLWQQKLLADEQSSQLDFWRSVLAGLPEEATLPADRPRAAVASYRGATHKV
                     SAPAVTHAALTGLARETGTTLFMVAQAAVASVLSRCGAGVDVPIGSPVAGRTDEALDDL
                     VGFFVNTLVLR"
     aSDomain        3660..4556
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38640_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="8.00E-116"
                     /label="IE233_RS38640_Condensation_LCL.1"
                     /locus_tag="IE233_RS38640"
                     /protein_end="300"
                     /protein_start="1"
                     /score="378.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIASDG"
                     /tool="antismash"
                     /translation="IPLSYAQQRLWFLAQLEGPSATYNIPLALRLSGDLDTEALTLALA
                     DVVARHESLRTVYPEREGTPYQHILPAEDARPELPVLAADEDTLADVLAAESAHVFGLA
                     ADLPVQARLIRLGEREHVLLVVMHHIASDGWSIAPLLRDLAHAYGARRAGHAPQQEPLE
                     IQYADYTLWQQEVLGEPDADDSLMNRQLAYWQDKLAGFPEEATLPADRPRPAVASYRGD
                     TVTVHCPPGTHTALADLARESGATLFMAAQAALATVLAVSGAGPDVPIGSPVAGRTDEA
                     LDDLVGFFVNTLVLRTDV"
     aSModule        3660..6797
                     /complete
                     /domains="nrpspksdomains_IE233_RS38640_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE233_RS38640_AMP-binding.1"
                     /domains="nrpspksdomains_IE233_RS38640_PCP.1"
                     /locus_tags="IE233_RS38640"
                     /monomer_pairings="Val -> Val"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3669..3698
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0001"
                     /evalue="4.10E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE233_RS38640"
                     /protein_end="14"
                     /protein_start="4"
                     /score="9.8"
                     /tool="antismash"
                     /translation="SYAQQRLWFL"
     CDS_motif       3720..3836
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0002"
                     /evalue="1.00E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE233_RS38640"
                     /protein_end="60"
                     /protein_start="21"
                     /score="59.7"
                     /tool="antismash"
                     /translation="ATYNIPLALRLSGDLDTEALTLALADVVARHESLRTVYP"
     CDS_motif       4038..4103
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0003"
                     /evalue="2.70E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE233_RS38640"
                     /protein_end="149"
                     /protein_start="127"
                     /score="35.9"
                     /tool="antismash"
                     /translation="MHHIASDGWSIAPLLRDLAHAY"
     CDS_motif       4152..4190
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0004"
                     /evalue="1.10E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE233_RS38640"
                     /protein_end="178"
                     /protein_start="165"
                     /score="14.8"
                     /tool="antismash"
                     /translation="QYADYTLWQQEVL"
     CDS_motif       4458..4547
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0005"
                     /evalue="1.70E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE233_RS38640"
                     /protein_end="297"
                     /protein_start="267"
                     /score="49.3"
                     /tool="antismash"
                     /translation="DVPIGSPVAGRTDEALDDLVGFFVNTLVLR"
     CDS_motif       4596..4715
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0006"
                     /evalue="4.60E-24"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE233_RS38640"
                     /protein_end="353"
                     /protein_start="313"
                     /score="76.9"
                     /tool="antismash"
                     /translation="RETDLGAWAHQDLPFDRLVEALNPERSGARHPLFQVMLTL"
     aSDomain        5073..6278
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38640_AMP-binding.1"
                     /evalue="6.00E-104"
                     /label="IE233_RS38640_AMP-binding.1"
                     /locus_tag="IE233_RS38640"
                     /protein_end="874"
                     /protein_start="472"
                     /score="339.8"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FAAQAARTPDAVALTHAGRSWTYAEADAVSSRFAHRLAGLGVGPE
                     TVVAVLMERSADLVLALLAIVKAGGVYAPLNAVDPASRLTRILADTAAPLLLVDRNLAD
                     HELVTEAGDTRVLLVDDLTADTETAAYPATAPEVAAHPDQWLYVMFTSGSTGVPKGVAV
                     THRNVTELALDHRWRRAAHQRVLFHSPHTFDASTFELWAPWLTGGTVAVAPAGVLDTAA
                     LAAVLAEESITGLWLTAGLFRLVAEEDPAAFTGLGEVWTGGDVVPPEAVRRVMDACPDL
                     QVVNGYGPTETTTFASAHPVRRPFDYAGALPIGRPLDNTRLYVLDDHLGLVAPGVPGEL
                     YIAGAGLARGYLRRPAQTAERFVADPHGPAGTRMYRTGDLVRWSRDGEIEYLGRADQQV
                     KLR"
     CDS_motif       5259..5300
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0007"
                     /evalue="3.00E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="IE233_RS38640"
                     /protein_end="548"
                     /protein_start="534"
                     /score="11.2"
                     /tool="antismash"
                     /translation="LAIVKAGGVYAPLN"
     CDS_motif       5511..5567
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0008"
                     /evalue="1.80E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IE233_RS38640"
                     /protein_end="637"
                     /protein_start="618"
                     /score="29.6"
                     /tool="antismash"
                     /translation="YVMFTSGSTGVPKGVAVTH"
     CDS_motif       6072..6158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0009"
                     /evalue="6.60E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS38640"
                     /protein_end="834"
                     /protein_start="805"
                     /score="53.6"
                     /tool="antismash"
                     /translation="PGVPGELYIAGAGLARGYLRRPAQTAERF"
     CDS_motif       6243..6308
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0010"
                     /evalue="3.00E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="IE233_RS38640"
                     /protein_end="884"
                     /protein_start="862"
                     /score="38.4"
                     /tool="antismash"
                     /translation="YLGRADQQVKLRGFRIEPGEIE"
     aSDomain        6591..6797
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38640_PCP.1"
                     /evalue="2.10E-27"
                     /label="IE233_RS38640_PCP.1"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1047"
                     /protein_start="978"
                     /score="87.1"
                     /tool="antismash"
                     /translation="EEVLCGLFADVLGRPSVTIDDHFLRLGGHSLLATRLVSRIRTAFG
                     VRITVRDMFQHPTVAQLNELIQTS"
     aSDomain        6843..>7717
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS38640_Condensation_LCL.2
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="9.30E-114"
                     /label="IE233_RS38640_Condensation_LCL.2"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1354"
                     /protein_start="1062"
                     /score="371.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIASDG"
                     /tool="antismash"
                     /translation="ARLPLSSAQQRLWFLDQLEGPSPTYNIPIALRLAGPLDVDALRRA
                     LTDVVGRHEALRTVFRVADGEAYQLVLAAAEIDVPLPVVPADEATLPALLAEESAKAFD
                     LTAQLPLRAALLQVTGEDHVLVVVTHHIASDGWSNAPFFADLDRAYAARTEGTAPGWEP
                     LPVQYADYTLWQQKLLADEQSSQLDFWRSVLAGLPEEATLPADRPRAAVASYRGATHKV
                     SAPAVTHAALTGLARETGTTLFMVAQAAVASVLSRCGAGVDVPIGSPVAGRTDEALDDL
                     VGFFVNTLVLR"
     CDS_motif       6858..6890
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0011"
                     /evalue="8.00E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1078"
                     /protein_start="1067"
                     /score="9.0"
                     /tool="antismash"
                     /translation="SSAQQRLWFLD"
     CDS_motif       6909..7025
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0012"
                     /evalue="1.00E-20"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1123"
                     /protein_start="1084"
                     /score="66.1"
                     /tool="antismash"
                     /translation="PTYNIPIALRLAGPLDVDALRRALTDVVGRHEALRTVFR"
     CDS_motif       7230..7292
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0013"
                     /evalue="3.00E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1212"
                     /protein_start="1191"
                     /score="26.2"
                     /tool="antismash"
                     /translation="HHIASDGWSNAPFFADLDRAY"
     CDS_motif       7341..7379
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0014"
                     /evalue="1.30E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1241"
                     /protein_start="1228"
                     /score="14.6"
                     /tool="antismash"
                     /translation="QYADYTLWQQKLL"
     CDS_motif       7527..7562
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0015"
                     /evalue="4.20E+01"
                     /label="C3_dual_135-156"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1302"
                     /protein_start="1290"
                     /score="-2.3"
                     /tool="antismash"
                     /translation="HAALTGLARETG"
     CDS_motif       7629..>7717
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS38640_0016"
                     /evalue="1.70E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE233_RS38640"
                     /protein_end="1354"
                     /protein_start="1324"
                     /score="49.3"
                     /tool="antismash"
                     /translation="DVPIGSPVAGRTDEALDDLVGFFVNTLVLR"
ORIGIN
        1 gcggcggtgg tcgtgcgtga ggaccgtccc ggcgacaagc gcctcgtcgc ctacgtcgtg
       61 gccgacggcg acacccgcgt cgacaccgaa gcgctgcgcc ggtacgccgg cacggcactg
      121 cccgagtaca tggtcccggc cgccttcgtg gaactcgacc tgctgccgct gaccgccaac
      181 ggcaagctcg accgccgtgc gctgcccgag cccaggctcg gcaccgggcc cggtggccga
      241 cagggtcgta cgcccgtcga agaggtgctg tgcgggctgt tcgcggacgc gctggggctg
      301 cccgccgtct ccatcgacga cgacttcttc cgcctcggcg ggcactccct gctcgccacc
      361 cgccttgtca gccgcgttcg gcgcaccctg ggcgcccggc tgtcggtacg cgatctgttc
      421 cggtggccca ccgtggcccg gatcgcggcg ttcatcgccg acggcacgga cgcggaccgg
      481 cggcccgcgc tggtggcggg ggagcggccc gagcggatac cgctgtcggc ggcccagcgg
      541 cggctgtggt tcctggacca gatggagggc ccctccgcca cctacaacat cccgctcgcc
      601 gtccggctcg tcggcaccct cgacaccgac gcgctgcacc tcgccctggg cgacgtcgtg
      661 gcccggcacg aggcgctgcg gaccgtcttc ccggccgagc agggcacccc gtaccagcag
      721 gtcctgcccg ccgaccgggc ccggcccgcg ccggcactga tcccggcgac ccgcgaggca
      781 ctgccggagc tcctgcgcga cctgtccgcc accaccttcg acctggcccg cgaactgccg
      841 ctgcgcgccg acctgttgcg ggtcgaggac gacgagcacg tgctgctcct cgtcatccac
      901 cacatcgcct ccgacggctg gtccaccacg cccctcgtgc gggacctggc cgccgcctac
      961 acggcccgcg ccgagggcac ggccccgagc tgggagccgc tgccggtcca gtacgccgac
     1021 tacgcgctgt ggcagcaggc gctgctcgcg gcggacgagg agcgccagct cgaccactgg
     1081 cgccgggtgc tcgacgggct gccggaggag gtgacgctgc ccgccgaccg ggcccggccc
     1141 gccaccgcct cgtaccgggg cgcctcgctg accgtgcgct gccccgcggg tctgcacgcc
     1201 tcgctcaccc ggctggcccg ggagagcggc accaccctgt tcatggtcgc gcaggcggcc
     1261 acgtcggccc tgctggcgcg ctccggcgcc ggcagcgaca tccccatcgg ttccccggtc
     1321 gcgggccgga gcgaggaggc gctggaggag ctggtcgggt tcttcgtcaa cacgctcgtg
     1381 ctgcgcaccg acgtcagcgg caacccgacc ttccgggaac tgctcgaccg ggtgcggacg
     1441 accgacctcg cggcctgggc acaccaggac gtgccgttcg accggctggt ggaggccctc
     1501 aacccggagc ggtccgccgc ccggcacccc ctcttccagg tcatgctgtc ggtcaccgac
     1561 gccgacaccc cggtgcccca actgccgggt ttgcaagccg agtcggagtt caccgcgctc
     1621 ggcatcgcca agttcgacct caccttcacc ttccacgagc accgcgcccc cgacggcggc
     1681 ccggccggtc tcggcatcac cgtcgagtac gccaccgacc tgtacgaccc ggcgaccgtc
     1741 tcggccgtcg ccgcacggct ggtacggctg ctccaggccg ccgccgacac cccggacgca
     1801 ccgatcggag ccctcgatgt cctggccgac gacgagcggg cgcggctgct cgacacctgg
     1861 cacggcaccc ggcaggtccg gccggccgcc gcgctgccgg agctgttcgc cgggcaggcc
     1921 gcccgcaccc ccgacgccgt cgccctctcg cacggcgaac agcgcctgac gtacgccgag
     1981 ttggaccgca gggcgaacct gctcgcccac cggctgatcg ccgagggggt gcggcccggc
     2041 tcccgggtgg cgctcttcca ggagcgctca ccggaggcgg tcgtcgcgat cctcgccgtc
     2101 gtcaaggccg gcgcggtgta cgtgccgctg gacacccgct acccgaagga ccgcgtcgac
     2161 ctcatcgtgc gcgtgtcggg cgcggaggtg ttcctcaccg accgcgacct gacgggcttc
     2221 gcactcccgg acggcgcgcg cgtcctgtcg gtcaccggac cggccggttc ctacgctgac
     2281 acggcccccg aggtcaccgt ccacccggac cagctcgcct acgtcatgtt cacctcgggc
     2341 tcgacgggcg tgccgaaggg cgtcgccgtc acccaccgca acatcaccga gctggccgcc
     2401 gacgaccgct tcaccggcgc cgcgcaccgc cgggtcctgc tgcactcgcc gctcgccttc
     2461 gacgcgacca cctacgaact gtgggtgccg ctgctgtccg gcggcaccct ggtcgtcgcc
     2521 ccgcccggcc tgctggacac ggccgcgctc acccggatac tcgccgagga gtcgatcacc
     2581 gggctgtggc tgacggcggg tctgttccgg ctggtcgccg aggaggaccc ggccgccttc
     2641 gcgggcctgc gcgaggtgtg gaccggcggt gacgtggtgc cgccggaggc ggtacggcgg
     2701 gtcatggacg cctgcccgga cctccaggtc gtgaacggct acgggcccac cgagaccacc
     2761 accttcgcca gcgcccaccc gctgcaccgc ccgttcgact acgcgggtgc cctgcccatc
     2821 ggccgccccc tcgacaacac ccggctctac gtcctcgacg agcacctgga gctggtcgcc
     2881 ccgggcgtcc ccggcgagct gtacatcgcc ggcaccggac tcgcccaggg ctatctggac
     2941 cggcccggcc tcaccgccga acggttcgtg gccgacccgt acggaccgcc gggcgtgcgc
     3001 atgtaccgca ccggtgacct ggtgcggtgg tcgcgggacg gtgaggtcga gtatctgggc
     3061 cgtgccgacc agcaggtcaa gctgcggggc ttccggatcg agccgggtga gatcgagtcg
     3121 gccctggtgg cccacccgtc cgtcgcccag gccgcggtgg tcgtgcgtga ggaccgcccg
     3181 ggcgacaagc gcctggtggc ctacgtcgtc ggcgagggcg tcgatctcga cgccctgcgc
     3241 accgacgcga gcgaggcact gcccgactac atggtcccgg ccgtcttcat ggccctggac
     3301 gccctgccgc tgaccgccaa cggcaagctc gacaagcgtg cgctgccccg gccccccgtc
     3361 gtggccggca gcggcggccg ggcgccgcgc aacccccgcg aggaagtcct gtgcggcctg
     3421 ttcgccgaag tcctcggcgt gccgtccgtc tccgtggacg acgacttctt ccgcctcggc
     3481 gggcacagcc tgctcgccac ccggctcatc agccggattc gtaccgtcct cggggccgaa
     3541 ctcccggtcc ccgccctctt cgagaacccg aacgtggcca ggcttgccga gcggctggac
     3601 cgcgcggaga gcgcgcgccc caagctgcgg ccgatgcgcc ggatgggagc ctcccagtga
     3661 tccccttgtc gtacgcccag cagcgcctgt ggttcctcgc ccaactggag ggcccctcgg
     3721 cgacctacaa catcccgctc gccctgcggc tgtccggcga cctcgacacc gaggcgctca
     3781 ccctggccct cgcggacgtc gtcgcccggc acgagagcct gcgcaccgtc taccccgagc
     3841 gtgagggcac cccgtaccag cacatcctgc ccgccgagga cgcccggccc gagctgcccg
     3901 tcctggcggc cgacgaggac accctcgcgg acgtcctcgc cgccgagtcc gcgcacgtct
     3961 tcggactcgc cgccgacctg cccgtccagg cccggctgat ccggctcggc gagcgggaac
     4021 acgtcctgct ggtcgtcatg caccacatcg cctccgacgg ctggtccatc gcccccttgc
     4081 tgcgcgacct ggcccacgcc tacggggccc gcagagcggg tcacgcgccc cagcaggaac
     4141 ccctggagat ccagtacgcc gactacaccc tctggcagca ggaggtgctc ggcgagccgg
     4201 acgccgacga cagtctcatg aaccgccaac tcgcctactg gcaggacaag ttggccggat
     4261 tccccgaaga ggccacgctg cccgccgacc ggccgcgccc cgccgtcgcc tcctaccgcg
     4321 gcgacaccgt caccgtgcac tgcccgcccg gaacgcacac cgctctcgcc gacctggccc
     4381 gcgagagcgg cgccaccctc ttcatggccg cacaggccgc actcgccacc gtgctcgccg
     4441 tctccggcgc gggccccgac gtcccgatcg gctccccggt cgccggccgc accgacgaag
     4501 ccctggacga cctcgtcgga ttcttcgtca acacgctcgt cctgcgcacc gacgtcgccg
     4561 gcgacccgac cttccgggaa ctcctcggac gggtgcggga gaccgacctg ggcgcctggg
     4621 cacaccagga cctgcccttc gaccggctgg tggaggccct caaccccgag cgcagcggcg
     4681 cccggcaccc cctcttccag gtcatgctca ccctggtgca ggccggctcc accgaccccg
     4741 gcaccgactt ccccggcctg cggacccgcg ccgagtactc ggccacccgc accgccaagt
     4801 tcgacctcac cgtcggcttc gacgagcacc tgacccccga cggcctgccc gccggcctcg
     4861 acatcaccgc cgagtacgcc accgacctgt acgaccccga gaccgtcgag gccctgctcg
     4921 gccggctgct gcggctgctc ggcgaggcgg ccgcgcaccc cgacaccccg ctgtccggcc
     4981 tcgacctcct cgacccggcc gaacgcaccc tgctgctcga cacctggacc ggccgcgcca
     5041 ccccggtgcc ggacgcctcc ctcgccgccc tcttcgccgc gcaggccgcc cgcacccccg
     5101 acgccgtcgc cctcacgcac gccggccgtt cctggacgta tgccgaggcc gacgccgtgt
     5161 ccagcaggtt cgcgcaccgc ctcgccgggc tcggcgtcgg cccggagacc gtcgtcgccg
     5221 tcctgatgga acgctccgcc gacctggtcc tcgccctgct ggccatcgtc aaggcgggcg
     5281 gcgtctacgc ccccctcaac gccgtcgacc cggcctcccg gctcacccgc atcctcgccg
     5341 acacggcagc cccgctcctc ctggtcgacc ggaacctcgc cgaccacgag ctcgtcaccg
     5401 aggccggcga cacccgggtc ctcctggtcg acgacctcac cgccgacacg gagaccgccg
     5461 cgtacccggc gaccgcccca gaggttgcgg cccaccccga ccagtggctg tacgtcatgt
     5521 tcacctcggg ctcgacgggc gtgccgaagg gcgtcgccgt cacccaccgc aacgtgaccg
     5581 aactcgccct cgaccaccgc tggaggcgcg ccgcgcacca gcgcgtcctc ttccactcgc
     5641 cgcacacctt cgacgcctcc accttcgaac tgtgggcgcc ctggctgacc ggcggcaccg
     5701 tcgccgtcgc accggccggc gtgctcgaca cggccgccct ggccgccgtg ctcgccgagg
     5761 agtcgatcac cgggctgtgg ctgacggcgg gcctgttccg gctggtcgcc gaggaggacc
     5821 cggccgcctt caccgggctc ggcgaggtgt ggaccggcgg tgacgtggtg ccgccggagg
     5881 cggtgcgacg cgtcatggac gcctgcccgg acctccaggt cgtcaacggt tacgggccca
     5941 ccgagaccac caccttcgcc agcgcccatc cggtccgccg cccgttcgac tacgcgggtg
     6001 ccctgcccat cggccgcccc ctcgacaaca cccggctcta cgtcctcgac gaccacctcg
     6061 gcctggtcgc cccgggcgtc cccggcgagt tgtacatcgc gggcgcaggc cttgcccgcg
     6121 ggtacctgcg ccgccccgcc cagaccgccg aacgcttcgt cgccgacccg cacggcccgg
     6181 ccgggacgcg catgtaccgc accggtgacc tggtgcggtg gtcgcgggac ggtgagatcg
     6241 agtatctggg ccgtgccgac cagcaggtca agctgcgcgg tttccggatc gagccgggtg
     6301 agatcgagtc cgccctggtg gcccacccgt ccgtcgccca ggccgcggtg gtcgtgcgtg
     6361 aggaccgccc gggcgacaag cgcctggtgg cctacgtcgt cggcgagcac gtcgacaccg
     6421 ccgccctgcg ccgccacgcg agcgaggcac tgcccgacta catggtgccg gccgccttcg
     6481 tcctcctcga caccctgccg ctgaccggca acggcaagct cgaccggcgc gccctgcccg
     6541 cacccgacct gagctccgac agcaccgggc gcgccccgcg cgaccccgca gaggaggtgc
     6601 tgtgcggcct gttcgccgat gttctcggcc gcccctccgt caccatcgac gaccacttcc
     6661 tgcgcctcgg cgggcactcc ctgctcgcca cccgcctcgt cagccgcatc cgcaccgcct
     6721 tcggcgtccg gatcaccgtc cgcgacatgt tccagcaccc cacggtcgcc cagctcaacg
     6781 agctgatcca gacgagcaag ggcgacaagg cgcgccccgc gctggtggcc ggcgtacgcc
     6841 ccgcacgcct cccgctctcc tccgcccagc aacggctctg gttcctcgac cagttggagg
     6901 gcccgtcacc gacgtacaac attccgatcg ccctccgcct cgccggcccc ctcgacgtcg
     6961 acgcactgcg gcgcgccctc accgacgtcg tcgggcgtca cgaggccctg cgcaccgtct
     7021 tccgggtggc ggacggcgag gcgtaccaac tcgtcctggc ggccgccgag atcgacgtac
     7081 ccctgccggt cgtacccgcc gacgaggcca cgctgcccgc gctgctcgcc gaggagagcg
     7141 ccaaggcctt cgacctcacg gcacaactcc cgctgcgggc cgccctgttg caggtgacgg
     7201 gcgaggacca cgtcctggtc gtcgtcaccc accacatcgc ctccgacggc tggtcgaacg
     7261 cccccttctt cgccgacctc gaccgcgcct acgcggcccg caccgagggc acggccccgg
     7321 gctgggagcc gctgccggtc cagtacgccg actacaccct ctggcagcag aagctgctgg
     7381 cggacgaaca gtcctctcaa ctcgacttct ggcgctcggt gttggccggg ttgccggagg
     7441 aggcgacgtt gccggccgat cggccgcgtg ctgctgtcgc ttcttatcgt ggggccactc
     7501 acaaggtgtc cgcccctgct gtcacgcatg ctgctctgac cgggttggcg cgtgagaccg
     7561 gtaccacgtt gttcatggtt gctcaggcgg ctgtggcgtc cgtgctttcg cggtgtggtg
     7621 cgggtgttga tgtcccgatc ggttcgccgg ttgcgggtcg tacggacgag gctctcgatg
     7681 atctcgtggg gttcttcgtc aatacgttgg ttctgcg
//
