LOCUS       NZ_BMUU01000019        35965 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence19, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000019
VERSION     NZ_BMUU01000019.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 138303)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 35965
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..35965
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /product="hydrogen-cyanide"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..35965
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="neighbouring"
                     /product="NRPS-like"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22928
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22928
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:2928](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <1..2928
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     gene            <1..2928
                     /db_xref="GeneID:96294992"
                     /locus_tag="IE233_RS34990"
     CDS             <1..2928
                     /NRPS_PKS="Domain: AMP-binding (133-530). E-value:
                     6.1e-101. Score: 329.9. Matches aSDomain:
                     nrpspksdomains_IE233_RS34990_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (634-702). E-value: 5.7e-25. Score:
                     79.3. Matches aSDomain: nrpspksdomains_IE233_RS34990_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (725-954). E-value: 6e-36.
                     Score: 116.9. Matches aSDomain:
                     nrpspksdomains_IE233_RS34990_Thioesterase.1"
                     /codon_start=1
                     /db_xref="GeneID:96294992"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="IE233_RS34990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_190029283.1"
                     /sec_met_domain="AMP-binding (E-value: 8e-109, bitscore:
                     356.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.2e-13, bitscore:
                     43.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.6e-06, bitscore: 20.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 8.6e-30, bitscore:
                     97.5, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-09, bitscore:
                     31.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PERSASRHPLFQVMLTVGDTAAGAPDLAGLEAAFLEPELRIAKFD
                     LTFAFGERRAADGSPDGLDIIVEYATDLYEPKTVGLLLERILLLLESAAADPDTAVGSI
                     LLLAPEERHLLDVWSGPATQAPELGLDGLFAGQAARSPEAPAVVFEDQVVSYGELEVWS
                     NRLARYLSGKGVRPGDLVAVHVERSPHMVAAILAVLKAGAGYTMLDPQFPEERLNAVLG
                     QVRPAVVVTQSHLPVLRSDAVRVDLTREVAEISAVSGGAVGTGGSPESVACVMFTSGST
                     GVPKGVAASHRALAATFVGPDYLAFGPEQTFLQCSPVSWDAFALEVFGPLLHGGVCVLQ
                     PGQHTDPHQIVELVERHQVTTLQMSASLFNHMLDEHPAVFGQIREAMTAGEAASPSHAA
                     KALARFPHLRLLNGYGPAESMGFTTTFTIEPGMAEGVASIPVGGPLSGKHAYVLDANLE
                     LVAPGVPGELYVSGHGLAHGYIGQPGLSADRFVANPYGLAGARMYRTGDLARWNKQGAL
                     EYLGRGDQQIKLRGFRIEPGEIEAALASHPQVQQAAAVVREDRPGDKRLVAYVVADTTD
                     TAALVRHTAARLPEYMVPAAVVVLEELPRTVNGKLDRRALPAPDLSAVSDGRAPRNPAE
                     EILCGLFADTLGLASVTIDDHFFHRGGHSLLATRLISRIRTVWGTRVTIRDLFQSPTPA
                     LLAEHIAAGSGSNPLDTVLPIRAPGRDTDTAPLFCVHAVSGVSWGYAGLLPHLGADRPL
                     VALQARRLGGTEDAPESIEEMADDYLAEIRKVQPHGPYHLLGWSFGGLVAHAVAARLEA
                     AGEEVALLALLDSYPLPDGFRAPEIDGRHVLTALLGSRGESVPVRCADSVPDIAELAEA
                     LRQSDPVLAGLEHTQAAAVVAATLDNLRMRYRYVPDVRFGGDALFFDATGTPAAQSGAA
                     AWAPYVGGRVEEFAVDCEHAAMTEAEPLRAVGEVLARRLRPAAHI"
     misc_feature    28..41
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     misc_feature    33..51
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.29"
                     /tool="antismash"
     aSDomain        403..1593
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS34990_AMP-binding.1"
                     /evalue="6.10E-101"
                     /label="IE233_RS34990_AMP-binding.1"
                     /locus_tag="IE233_RS34990"
                     /protein_end="530"
                     /protein_start="133"
                     /score="329.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FAGQAARSPEAPAVVFEDQVVSYGELEVWSNRLARYLSGKGVRPG
                     DLVAVHVERSPHMVAAILAVLKAGAGYTMLDPQFPEERLNAVLGQVRPAVVVTQSHLPV
                     LRSDAVRVDLTREVAEISAVSGGAVGTGGSPESVACVMFTSGSTGVPKGVAASHRALAA
                     TFVGPDYLAFGPEQTFLQCSPVSWDAFALEVFGPLLHGGVCVLQPGQHTDPHQIVELVE
                     RHQVTTLQMSASLFNHMLDEHPAVFGQIREAMTAGEAASPSHAAKALARFPHLRLLNGY
                     GPAESMGFTTTFTIEPGMAEGVASIPVGGPLSGKHAYVLDANLELVAPGVPGELYVSGH
                     GLAHGYIGQPGLSADRFVANPYGLAGARMYRTGDLARWNKQGALEYLGRGDQQIKLR"
     aSModule        403..2865
                     /complete
                     /domains="nrpspksdomains_IE233_RS34990_AMP-binding.1"
                     /domains="nrpspksdomains_IE233_RS34990_PCP.1"
                     /domains="nrpspksdomains_IE233_RS34990_Thioesterase.1"
                     /final_module
                     /locus_tags="IE233_RS34990"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       589..630
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS34990_0001"
                     /evalue="2.10E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="IE233_RS34990"
                     /protein_end="209"
                     /protein_start="195"
                     /score="11.7"
                     /tool="antismash"
                     /translation="LAVLKAGAGYTMLD"
     CDS_motif       817..876
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS34990_0002"
                     /evalue="5.10E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IE233_RS34990"
                     /protein_end="291"
                     /protein_start="271"
                     /score="28.2"
                     /tool="antismash"
                     /translation="ACVMFTSGSTGVPKGVAASH"
     CDS_motif       1387..1473
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS34990_0003"
                     /evalue="4.90E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS34990"
                     /protein_end="490"
                     /protein_start="461"
                     /score="44.4"
                     /tool="antismash"
                     /translation="PGVPGELYVSGHGLAHGYIGQPGLSADRF"
     CDS_motif       1558..1623
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS34990_0004"
                     /evalue="1.80E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE233_RS34990"
                     /protein_end="540"
                     /protein_start="518"
                     /score="36.0"
                     /tool="antismash"
                     /translation="YLGRGDQQIKLRGFRIEPGEIE"
     aSDomain        1906..2109
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS34990_PCP.1"
                     /evalue="5.70E-25"
                     /label="IE233_RS34990_PCP.1"
                     /locus_tag="IE233_RS34990"
                     /protein_end="702"
                     /protein_start="634"
                     /score="79.3"
                     /tool="antismash"
                     /translation="EEILCGLFADTLGLASVTIDDHFFHRGGHSLLATRLISRIRTVWG
                     TRVTIRDLFQSPTPALLAEHIAA"
     CDS_motif       2179..2208
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS34990_0005"
                     /evalue="5.10E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="IE233_RS34990"
                     /protein_end="735"
                     /protein_start="725"
                     /score="9.9"
                     /tool="antismash"
                     /translation="PLFCVHAVSG"
     aSDomain        2179..2865
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS34990_Thioesterase.1"
                     /evalue="6.00E-36"
                     /label="IE233_RS34990_Thioesterase.1"
                     /locus_tag="IE233_RS34990"
                     /protein_end="954"
                     /protein_start="725"
                     /score="116.9"
                     /tool="antismash"
                     /translation="PLFCVHAVSGVSWGYAGLLPHLGADRPLVALQARRLGGTEDAPES
                     IEEMADDYLAEIRKVQPHGPYHLLGWSFGGLVAHAVAARLEAAGEEVALLALLDSYPLP
                     DGFRAPEIDGRHVLTALLGSRGESVPVRCADSVPDIAELAEALRQSDPVLAGLEHTQAA
                     AVVAATLDNLRMRYRYVPDVRFGGDALFFDATGTPAAQSGAAAWAPYVGGRVEEFAVDC
                     EHAAMTE"
     CDS_motif       2359..2433
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS34990_0006"
                     /evalue="1.70E-15"
                     /label="NRPS-te1"
                     /locus_tag="IE233_RS34990"
                     /protein_end="810"
                     /protein_start="785"
                     /score="49.2"
                     /tool="antismash"
                     /translation="QPHGPYHLLGWSFGGLVAHAVAARL"
     gene            3245..4162
                     /db_xref="GeneID:96294993"
                     /locus_tag="IE233_RS34995"
                     /old_locus_tag="GCM10010326_71330"
     CDS             3245..4162
                     /codon_start=1
                     /db_xref="GeneID:96294993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240932.1"
                     /locus_tag="IE233_RS34995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71330"
                     /product="kinase"
                     /protein_id="WP_202519563.1"
                     /transl_table=11
                     /translation="MVDHSGWRVGVASAPIHHGEILQGVFPHQGQLSRGLVTMPCTVHT
                     TQASFIPARGEELTVSPSWKSKARRAAQLAVQACVRPEDGPVGGHLELTGDVPLCRGFG
                     SSTSDVLAAIWAVQDAFVAPLPPEAVARIAVCAETASDSLMFKESSVLFAQREGKVIED
                     FGYRMPAVRVLGFGSRPENEGKGIDTLAFPPARYDSTEIEDFAELHAMLREAIHTKDVA
                     LVGAVASASTAINQRHLPIPLLDSLRVIERETGALGIQTAHSGDIAGLLYDRDDPEVDA
                     RTEHGRRLLHNIGIHEQWIFTTGD"
     gene            4164..5222
                     /db_xref="GeneID:96294994"
                     /locus_tag="IE233_RS35000"
                     /old_locus_tag="GCM10010326_71340"
     CDS             4164..5222
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294994"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669230.1"
                     /locus_tag="IE233_RS35000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71340"
                     /product="PLP-dependent cysteine synthase family protein"
                     /protein_id="WP_190029284.1"
                     /sec_met_domain="PALP (E-value: 2.9e-38, bitscore: 124.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTFTIAGAARVHDSVVDATELPRIIQVTDNLYATAFSLMKLLPA
                     RFIVDRAEAAGLLRPGTRIIETSSGTFALGLAMVCRLRGYDLTIVGDSAIDRDLRNRLE
                     MLGATVEIVEHTGQPGGIQGARLARVEELRRLHPDSFVPGQYDNPDNPGAYAVVAQLIG
                     ETVGSVDCLVGPVGSGGSTGGLAAALRPTDPALHLVGVDTHGSIIFGTPDGPRTLRGLG
                     SSIHPGNVRHAAYDEVHWVTAAEAFHATHELFRNHGLFMGPTSGASFQVASWWAARNPE
                     SKVVMVLPDEGYRYQSTVYNTDWLTAQGIEPAPTPGGPVTVAHPLDAPESWSRLVWARR
                     GFDDVMMPGADA"
     gene            5219..6478
                     /db_xref="GeneID:96294995"
                     /locus_tag="IE233_RS35005"
                     /old_locus_tag="GCM10010326_71350"
     CDS             5219..6478
                     /codon_start=1
                     /db_xref="GeneID:96294995"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669229.1"
                     /locus_tag="IE233_RS35005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71350"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_190029285.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 4.8e-14, bitscore:
                     45.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.3e-08,
                     bitscore: 25.8, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPLLLFVESNTTGTGRQFAQRARAFGAEPVLLSADPGRYPYAA
                     DDELRTVVVDTADGDALWAAVQRLAAGARVAGVLSSSEYYVAAAADLAARLGLPGPSAD
                     AVRACRDKSVQRRSLADAGVPVPRFSVAGTVADAVAAAQWQGGPVVVKPVQGSGSLGVR
                     LCRDSGEVVAHAGELLSATVNERGLRTPARVLVEQYLTGAEFSVEVFGEHAVVTVAKHV
                     GEPPVFVETGHDVPAVLPAPEAAALADSAVHAVKALGLGWGAAHVELRLDGGVARVIEV
                     NPRLAGGMIPELVRRARGIDLVGAQVRAGLGLPVDLIGTSGTVGAASIRFLTADGDAVL
                     GDTDAAEAAALAVPGAVDAALYRPPGTRVGPAEDFRGRLGHVIAVADRPEESARAADTA
                     RSLGLATALEHAPVKEEMPV"
     gene            6475..7986
                     /db_xref="GeneID:96294996"
                     /locus_tag="IE233_RS35010"
                     /old_locus_tag="GCM10010326_71360"
     CDS             6475..7986
                     /codon_start=1
                     /db_xref="GeneID:96294996"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012432.5"
                     /locus_tag="IE233_RS35010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71360"
                     /product="argininosuccinate lyase"
                     /protein_id="WP_190029286.1"
                     /transl_table=11
                     /translation="MTTPSQAVGAGGVDTGRLRTALDARAHRIVYDQYRPGADDPIGQE
                     LRLISEVDRAHLVMLAERGIVDTARAGALLGTIDTLRADDFAAVRDRPMPRGLYLAYEG
                     WLVDRLGQETGGVLHTGRSRNDLNATTVRLRVRGPYGQLVSEVLELAEVLLDRAERYRD
                     VTMPAYTHGQPAVPISYGHYLCGVAGAVLRSAEALLDAGREIDVNPLGAGAVGGTSVPV
                     DPGRTGELLGFTGVAPNSVDAVASRDFALRMLSAAAVLGVLMARIARDLTWWTTEEFGL
                     LRMADDLVGSSSMMPQKRNPFLLEHVQGRSSAALAGFTGAATAMSTAGYTNAIAVGTEA
                     VRHLWPGLAGTEEAATLLRLVVAGAEPDRARMTARARDGFTSATYLAERLVVDGMPFRT
                     AHHLVGETVLAALDGGLPLSEAARAQPAVAEAAAGYPADWLDPETVAAACAHGGGPGGA
                     APDAALTRARTELAAARREFGDRRARWADAADRLTDEVAKVMTVR"
     gene            7983..9362
                     /db_xref="GeneID:96294997"
                     /locus_tag="IE233_RS35015"
                     /old_locus_tag="GCM10010326_71370"
     CDS             7983..9362
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294997"
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087828.1"
                     /locus_tag="IE233_RS35015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71370"
                     /product="MFS transporter"
                     /protein_id="WP_190029287.1"
                     /transl_table=11
                     /translation="MNTATAAPPRPRGGLLGQRDFRLLWAGETMSRFGSNITGVAMPLA
                     AVVSLDASTFWVSALAAAAWLPWLLVGLPAGAWVDRLPRRPLMLVCNLGSLVLLASVPA
                     AAWLDVLTMTQLMVVALLTGLANVFFSIAYRVYLPSVVRREDLAEANAKLQGSESAAQL
                     AGLGGGGMLAGLFGAVSGLLVDAGTFLASTLCLLGIRSTEPRPEAPAVPRPLRQEVRDG
                     LHYTLRDPYLRVLTAYGTVTNLLLTGYQALLTVFLVRDLGVGASAVGWLLAGASVGGLL
                     GAVVAGSLSRRFGSARGMLLCKFATAPFGLLVPLAEPGWRVVLLALGGAVLALGVVSAN
                     VIQGTFRQQYCPPHLLGRITASMSVANFGAIPVGSLLGGILGSALGVRPALWMLTGGLA
                     VSSALLLAGPLRARRDLPIEPPLPEGELRCSASPPARTSPGAERDASDGGPRRHPSGRG
                     R"
     gene            9370..10164
                     /db_xref="GeneID:96294998"
                     /locus_tag="IE233_RS35020"
                     /old_locus_tag="GCM10010326_71380"
     CDS             9370..10164
                     /NRPS_PKS="Domain: ACPS (147-198). E-value: 1.5e-08. Score:
                     26.5. Matches aSDomain:
                     nrpspksdomains_IE233_RS35020_ACPS.1"
                     /codon_start=1
                     /db_xref="GeneID:96294998"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849254.1"
                     /locus_tag="IE233_RS35020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71380"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_190029288.1"
                     /transl_table=11
                     /translation="MSGSPSASATLLHPAAPPGRPLPQPGSLDLYLIRVPDIRGAALDT
                     AVLDPTERHRAAELAHADDRIRFTTAHLALRRLLGTYLDTRPQDIRYGRETCPCCGGPH
                     GRPTVLGASRELHFSLSHRGDLVLMGTAVAPIGVDVDLITDPGSAAELAAMLHPAEQAE
                     IAALPPVRRPRELARLWTRKEAYLKGLGTGLGRDPAADYVGSGSSNGPCPPPGWTVLDI
                     PVDRGYAAAVAVHGALTIAAPRVNRLSDHDIRDGPPGGTGRR"
     aSDomain        9811..9963
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS35020_ACPS.1"
                     /evalue="1.50E-08"
                     /label="IE233_RS35020_ACPS.1"
                     /locus_tag="IE233_RS35020"
                     /protein_end="198"
                     /protein_start="147"
                     /score="26.5"
                     /tool="antismash"
                     /translation="SAAELAAMLHPAEQAEIAALPPVRRPRELARLWTRKEAYLKGLGT
                     GLGRDP"
     gene            complement(10215..11087)
                     /db_xref="GeneID:96294999"
                     /locus_tag="IE233_RS35025"
                     /old_locus_tag="GCM10010326_71390"
     CDS             complement(10215..11087)
                     /codon_start=1
                     /db_xref="GeneID:96294999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236219.1"
                     /locus_tag="IE233_RS35025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71390"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_190029289.1"
                     /transl_table=11
                     /translation="MSARRTAASLGVLGATSLTLLCLTPTAASAHGAMFNPVSRIAACY
                     AEGPEHPVSQVCKDLVADSGTQPLYDWNEVNIANANGQSRQLIPDGKLCSANRDKYRAL
                     DWARTDWPSTGVAAGKFDFKFRATAAHSGTMTVYITKQGFDPTKPLKWSDLDNTPVATY
                     QTPRTATDGYYNFTGTLPARTGRHIIYKVWQRDDSPEAFYSCSDVVYGGAAKAAAAPTE
                     QKITAGAAHSTVSHHGHGGDPVTATTPAAAPAASSASTGGSAAPQALAAASAAGVAGGG
                     FLLLRRRRD"
     misc_feature    complement(11076..11091)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.68"
                     /tool="antismash"
     misc_feature    11214..11229
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.92"
                     /tool="antismash"
     misc_feature    complement(11215..11228)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            11434..12702
                     /db_xref="GeneID:96295000"
                     /gene="cbiE"
                     /locus_tag="IE233_RS35030"
                     /old_locus_tag="GCM10010326_71400"
     CDS             11434..12702
                     /GO_function="GO:0046025 - precorrin-6Y
                     C5,15-methyltransferase (decarboxylating) activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0046140 - corrin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295000"
                     /gene="cbiE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578011.1"
                     /locus_tag="IE233_RS35030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71400"
                     /product="precorrin-6y C5,15-methyltransferase
                     (decarboxylating) subunit CbiE"
                     /protein_id="WP_190029290.1"
                     /sec_met_domain="TP_methylase (E-value: 5e-23, bitscore:
                     75.1, seeds: 87, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.4e-06, bitscore: 21.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHPRTPHPDVTVVGIGADGWGGLGGAARAVLGAAEVVVGGARQL
                     ALLPKDACRGERVAWPSPLRPAVPELIAAHAGRRIAVLASGDPMFYGIGRTLTEVLGTP
                     LRVLPHPSSVAYACARLGWSVEETEVVTAVGRPLARVAAALHRGRRLLVLSAGAGTPAE
                     VAALLCDRGFGPSRMWVLDQLGSEDEQCRDGVAEAWDEPAHDALNVVAVDCRRAPGALR
                     LGAVPGLPDAAYEHDGQLTKRHVRAATLGALAPAPGELLWDIGGGSGSIAVEWMRTHPS
                     CRAFSVERDPVRADRIRRNAERLGVPGLGVVLGGAPGALGQLPPPDAVFIGGGLTAPGL
                     LDACWDALPVGGRLVANTVTLESEALLAECYRRHGGDLVRLAVAHAVPVGTFTGWRQAM
                     PVTQWAVAKAGPAPLNTSPGDDR"
     gene            12699..13442
                     /db_xref="GeneID:96295001"
                     /gene="cobM"
                     /locus_tag="IE233_RS35035"
                     /old_locus_tag="GCM10010326_71410"
     CDS             12699..13442
                     /EC_number="2.1.1.133"
                     /GO_function="GO:0046026 - precorrin-4
                     C11-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295001"
                     /gene="cobM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998898.1"
                     /locus_tag="IE233_RS35035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71410"
                     /product="precorrin-4 C(11)-methyltransferase"
                     /protein_id="WP_161251383.1"
                     /sec_met_domain="TP_methylase (E-value: 1.3e-42, bitscore:
                     139.1, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYFIGAGPGAADLITVRGARTLASCRVCLYAGSLVPRELLAEC
                     PDGARLVDTAQLDLDEITGELVRAHEAGHDVARLHSGDPSVFSAVAEQMRRLDAAGVPY
                     EVVPGVPAFAAAAAALKRELTVPTVGQTVILTRVAQRATAMPEGEDLATLGRSGALLVL
                     HLATGYVDRVVEELLPHYGADCPAAVVAFASRPEEVVLRGTLSDIAGQVKDAGIVRTAV
                     ILVGRTLGAAEFRDSHLYSADRHRC"
     gene            complement(13453..14607)
                     /db_xref="GeneID:96295002"
                     /locus_tag="IE233_RS35040"
                     /old_locus_tag="GCM10010326_71420"
     CDS             complement(13453..14607)
                     /EC_number="2.1.1.195"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006373434.1"
                     /locus_tag="IE233_RS35040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71420"
                     /product="cobalt-precorrin-5B (C(1))-methyltransferase"
                     /protein_id="WP_229893047.1"
                     /transl_table=11
                     /translation="MSEAKGGRGAQLKHTGLRPGWTTGACATAATTAAYTALLTGDFPD
                     PVTITLPRGQTPAFALAAEELAPAQPAAGRGAAAGHAMAAVVKDAGDDPDVTHGALVRS
                     TVRLLPPGSGVVFRAGEGVGTITRPGLPLPVGEPAINPVPRQMMRDHVALVAERHGAPG
                     DVEITISVDHGAEIARSTWNPRLGILGGLSILGTTGIVVPYSCSAWIDSIRRGVDVARA
                     AGRTHVAGCTGSTSEKTVVAEHGLPEDALLDMGDFAGAVLKYVRRHPVDRLTICGGFAK
                     LSKLAAGHLDLHSARSQVDKPFLAELARRGGASEALAAEVADANTGLAALQLCTAAGVR
                     LGDLVAARARDEALSVLRGAPVTVDVICIDRAGNVVGRSEPAGP"
     gene            14663..15409
                     /db_xref="GeneID:96295003"
                     /locus_tag="IE233_RS35045"
                     /old_locus_tag="GCM10010326_71430"
     CDS             14663..15409
                     /EC_number="1.3.1.106"
                     /GO_function="GO:0016994 - precorrin-6A reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523567.1"
                     /locus_tag="IE233_RS35045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71430"
                     /product="cobalt-precorrin-6A reductase"
                     /protein_id="WP_190029291.1"
                     /transl_table=11
                     /translation="MHVLILGGTGEARRLAGLLCDAGVTSLRVTSSLAGRVAEPRLPPG
                     EVRVGGFGGPEGLAAWLRAHAVDALIDATHPFAGTISFNAARAAAEAHVPLLALRRPGW
                     VPGAGDRWHPAGSLEEAAALLPALGRRVFLTTGRMGLAAFARLDALWFLMRSVDAPEPP
                     FPAAMEVLLDRGPFTLEGEREVLRTHRIDVLVTKDSGGAATAPKLAAAREAGIPVVVVR
                     RPPVPDGVERAATPEEAAAWVRRFTG"
     gene            complement(15432..16937)
                     /db_xref="GeneID:96295004"
                     /locus_tag="IE233_RS35050"
                     /old_locus_tag="GCM10010326_71440"
     CDS             complement(15432..16937)
                     /EC_number="2.1.1.130"
                     /GO_function="GO:0030788 - precorrin-2
                     C20-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295004"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047285.1"
                     /locus_tag="IE233_RS35050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71440"
                     /product="precorrin-2 C(20)-methyltransferase"
                     /protein_id="WP_161251377.1"
                     /sec_met_domain="TP_methylase (E-value: 2.1e-52, bitscore:
                     171.1, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSENSSTAGRLYGVGLGPGDPSLMTVRAVEAIAEADVVAYHSARH
                     GRSIARSIAAKHIRADHIEEKLVYPLTVETTDHPGGYRGALNDFYEEASARLAEHLDAG
                     RTVAVLAEGDPLFYGSYQHMHKRLAHRYPTEVIPGVTSVSAAAARLGEPLVEAEEVLTI
                     LPGTLPEEELTARLAATDSAVVMKLGRTFTKVRRALERSGRLDEARYVERATMAGERTG
                     RLADIEAESVPYFSVAVLPSRIDATPPVRERGEVVVVGTGPAGPLWLTPESRGALAAAD
                     DIVGYTTYVDRVPERPGQLRHGSDNKVESERAEFALQLAMRGRRVAVVSGGDPGIFAMA
                     TAVLEVASQPEYAQVPVRVLPGVTAANAAAARAGAPLGHDYATISLSDRLKPWDVIAER
                     LDAAASADLVLALYNPGSASRTWQVAKARELLLEHRLPDTPVVVARDVGGPTERVRIVR
                     LTDLDPAEVDMRTILLVGSSQTRTVRRGDGEEIVWTPRRYPEG"
     gene            complement(16934..17575)
                     /db_xref="GeneID:96295005"
                     /locus_tag="IE233_RS35055"
                     /old_locus_tag="GCM10010326_71450"
     CDS             complement(16934..17575)
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948117.1"
                     /locus_tag="IE233_RS35055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71450"
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_161251375.1"
                     /transl_table=11
                     /translation="MSESTVFDYEKDGAEIYRQSFATIRAEADLGGLPADVSQVAVRMI
                     HACGMTDLTRDLGWTPGVVARAREALRAGAPILCDARMVASGVTRKRLPADNEVLCTLN
                     DPSVPDLAAKLNTTRSAAALELWRDRLDGAVVAVGNAPTALFRLLEMIEEGAPRPAAVI
                     GVPVGFIGAAESKDALAAHPSGLEHLVVRGRRGGSAIAAAALNAIASEAE"
     gene            complement(17643..18962)
                     /db_xref="GeneID:96295006"
                     /locus_tag="IE233_RS35060"
                     /old_locus_tag="GCM10010326_71460"
     CDS             complement(17643..18962)
                     /codon_start=1
                     /db_xref="GeneID:96295006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980411.1"
                     /locus_tag="IE233_RS35060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71460"
                     /product="cobalamin biosynthesis protein CobG"
                     /protein_id="WP_190029344.1"
                     /transl_table=11
                     /translation="MLAAMPPPSSTPPNQGEPPIGGTPGEVAPGPVVRDRDDACPGALR
                     LHTADDGKLARLRLPGGILTNRQVEALAVAAERYGDGHLGITSRGNAELRGIGDHCGNG
                     LAELLRHTALLPSERHERVRNIVASPLAGLDGLGHGGLHSWLRELDALLCAQDWTTALS
                     GRFLFALDDGRGDVTGLGGDVTLLAQGEGAALVRTGGAAPLRVAAADAPRAALAAARAF
                     LAAADAAGTGAWRVRELPRGHEVDLAAALASAGIPAEPAPVPHTAPASAPRPGVAPGPD
                     GTYAVLVAPVLGRVTGAQLRALAGPGGEVRITPWRGFVVPGFEERGAHERLEELGAAGF
                     ITGPGSPWSGVGACTGRPGCAKALADVRRDALPGSGGLPVYWSGCERRCGHPHGDWVDV
                     TATADGRYTVTARSGMAEQQLPYAEGKLADTIGRARGGGR"
     regulatory      19253..19338
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            19430..23059
                     /db_xref="GeneID:96295007"
                     /gene="cobN"
                     /locus_tag="IE233_RS35065"
                     /old_locus_tag="GCM10010326_71470"
     CDS             19430..23059
                     /EC_number="6.6.1.2"
                     /GO_function="GO:0051116 - cobaltochelatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295007"
                     /gene="cobN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1263: cobaltochelatase subunit CobN"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003956840.1"
                     /locus_tag="IE233_RS35065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71470"
                     /product="cobaltochelatase subunit CobN"
                     /protein_id="WP_190029292.1"
                     /transl_table=11
                     /translation="MLHTSGEPAEDPRPILLLSTSDTDLLSARAANGPVPYRFANPSRL
                     ALDTLPALLDGVGLVVVRLLGGVRAWQDGLDQLTASGLPVVVLTGEQAPDAQLMAASTV
                     PVGIAAEAHAYLAHGGPANLDQLARFLSDTVLLTGHGFEPPAPAPSWGPLERTARPVEG
                     PVVAVLYYRAHHMSGNTAFVDTLCGAIEDAGGRPLPLYVSSLRDPEPALIDELRAADAI
                     VTTVLAAGGTKPATASAGGDDESWDAGALSGLDVPILQALCLTGSRSAWEENDEGVSPL
                     DAASQIAVPEFDGRLITVPFSFKEIDADGLPAYVADAERSARAAGIAVRHARLKHIPAA
                     DKRIALVLSAYPTKHSRIGNAVGLDTPASAVALLRRLRAEGYDFGPEDEIPGLVSGDGD
                     ELIRALIDAGGHDQDWLTEEQLAANPVRIPAADYKRWYATLPEELRTNVEQHWGPPPGE
                     MFLDRSRNPEGDIVLAALRRGNLLILIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWI
                     AASAADSGFGADAMIHLGKHGNLEWLPGKNAGLSAACGPDAALGDLPLVYPFLVNDPGE
                     GTQAKRRVHATLIDHLVPPMARADSYGDIARLEQLLDEHAQIASMDPAKLPAIRAQIWT
                     LIQAAKLDHDLGLEDRPEDEGFDEFIMHLDGWLCEIKDVQIRDGLHVLGNAPAGADRVN
                     LVLAILRARQIWGGTTALPGLREALGLDESAATRTSADEAEEQARALVQLMDDADWDLA
                     AIPADQPQQVRAILEFAAREVVPRLAATTAELDHTVHALNGGFVPAGPSGSPLRGLVNV
                     LPTGRNFYSVDPKAVPSRLAWETGQALAESLANRYRTDNGDWPTSVGLSLWGTSAMRTA
                     GDDVAEAMALLGVRPVWDDASRRVTGLEPIPLDELGRPRIDVTLRISGFFRDAFPHTIG
                     LLDDAVRLAASLEEPAEDNYVRAHTQADLAEHGDERRATTRIFGSRPGTYGAGLLQLID
                     SRDWRTDADLAEVYTVWGGYAYGRELDGRPARDEMETAYKRIAVAAKNTDTREHDIADS
                     DDYFQYHGGMVATVRALRGTAPEAYIGDSTRPETVKTRTLVEETSRVFRARVVNPKWIE
                     AMRRHGYKGAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPANREFLQNANPWA
                     LHGIAERLLEAESRGMWAKPDPAVLEALRQVYLETEGDLEDQD"
     cand_cluster    22826..35965
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    22826..35965
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[27825:30965](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      27826..30965
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="2"
     gene            complement(23138..24796)
                     /db_xref="GeneID:96295008"
                     /locus_tag="IE233_RS35070"
                     /old_locus_tag="GCM10010326_71480"
     CDS             complement(23138..24796)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888934.1"
                     /locus_tag="IE233_RS35070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71480"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_190029293.1"
                     /transl_table=11
                     /translation="MISEQIAAVVVAARDGDQRARDELVAGYLPLVYNIVGRALGGHAD
                     VDDVVQESLLRMLDGLGSLREPAAFRSWLVAVTMNEIRRYWQGHRRTPVDGGLQDAHDL
                     ADPGADFVDLTIVRLGLSGQRKEVTEATRWLEPDDRALLSLWWLEAAGVLSRGEVASAL
                     DLSAEHAAVRVQRMKGQLETARVVVRALAGIERCGELYGLALSWDGVPSALWRKRIARH
                     ARTCAVCSGHWSGLIPAEGLLVGLALVPVGAATAGLLAVLGGRAPALETTAHATAATQP
                     SPRAAHGAHAAGRRRAPASRRDRRDRRARRRRRAAAVIAGLAAVAALGGAYRFVTDPGQ
                     DSSRTVADAPLTTTDAASADGISTGPLSPSPSASNSPSKASSSPSPSAPVKHSSPPPAS
                     KSPTHAAPPRPAPSTKRAPAGPDDGTPAAVQQVLDLVNSERGKAGCSALTSNPKLYDAA
                     LKHSENMAAQNFFDHTDPSGAGPGERITAAGYQWSSYGENIARGQADAAAVMDSWMHSP
                     GHRANILNCGYKEIGIGVHYGSGGPWWTQDFGTRS"
     misc_feature    24792..24807
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.2"
                     /tool="antismash"
     misc_feature    complement(24874..24888)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.45"
                     /tool="antismash"
     misc_feature    complement(24954..24969)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            24995..25315
                     /db_xref="GeneID:96295893"
                     /locus_tag="IE233_RS39950"
                     /old_locus_tag="GCM10010326_71490"
     CDS             24995..25315
                     /codon_start=1
                     /db_xref="GeneID:96295893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007263735.1"
                     /locus_tag="IE233_RS39950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71490"
                     /product="hypothetical protein"
                     /protein_id="WP_373300278.1"
                     /transl_table=11
                     /translation="MSDIPASEAERPPEPERPHEAAPVPAAVPGAVRGTVPKPTPMPPP
                     TPDITYTQCKRCGTELAGLDGRYSCGVCGWSNHWSEGHRPLPRAEDDPDAPPTPVNPLG
                     EQ"
     gene            complement(25331..25933)
                     /db_xref="GeneID:96295009"
                     /locus_tag="IE233_RS35080"
                     /old_locus_tag="GCM10010326_71500"
     CDS             complement(25331..25933)
                     /codon_start=1
                     /db_xref="GeneID:96295009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075631.1"
                     /locus_tag="IE233_RS35080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71500"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_161257136.1"
                     /transl_table=11
                     /translation="MFGYVIIPGIDGSDEHHWQSEWERHWGPSAVRTAPDSWSEPDLED
                     WVAAVGSAVDEASRKHDHVVLVAHSLGCWAAATWLGRNPSPAATAAFLVAPPDPLSPAF
                     PSGSAPTFTQLSARPLPVPALVVAGTNDPYCAPETSAAFAAQWGAHHHLAGPIGHINSG
                     SLLGSWEEGRDLLDSLLPPAHTPDLTPTPAPAPDTAA"
     misc_feature    25927..25940
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.54"
                     /tool="antismash"
     misc_feature    complement(26068..26081)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.34"
                     /tool="antismash"
     gene            26102..27220
                     /db_xref="GeneID:96295010"
                     /locus_tag="IE233_RS35085"
                     /old_locus_tag="GCM10010326_71510"
     CDS             26102..27220
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382437.1"
                     /locus_tag="IE233_RS35085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71510"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_190029294.1"
                     /transl_table=11
                     /translation="MSDPEFRRRALLATLPMAFAASGCEAAAPRRERDRRPVQGPPPGP
                     VRQPGVAEPQQPHMLFVSYDLTPGTRGAPGRDAVRRLLARWSELLAGLAPGPTATVGIG
                     PGLPERLGVGAPEGLRELPAFVGEHLDVAAGGGEIGVQICARDARGCERLAGLLAGAGA
                     GVLRPRWRQAGFLSGERPGPRSELLAPPRAGEASRDLLGFKNGTSNPTAAENERWVWLP
                     PGGRYADGTFLVVRRIRLRVEEFGRLPVARQEQIVGCRKGGGEVLSSDLNARTPEGSYV
                     LPLDAHVRLAGPGPDGGARMLRRSYSYENSPGDRGMLFLAYMRDPALFVRVGTRLAASD
                     ALNSFAEQYGSALFYVLPGVGGSGRALGSTVL"
     misc_feature    27689..27705
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.14"
                     /tool="antismash"
     misc_feature    complement(27690..27705)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     misc_feature    27801..27816
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            27826..28986
                     /db_xref="GeneID:96295011"
                     /locus_tag="IE233_RS35090"
                     /old_locus_tag="GCM10010326_71520"
     CDS             27826..28986
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295011"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938974.1"
                     /locus_tag="IE233_RS35090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71520"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_190029295.1"
                     /sec_met_domain="DAO (E-value: 2.7e-67, bitscore: 220.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTPDVIVVGAGIVGAACAYYAARAGLRVTVLDRGPVAGGTTGS
                     GEGNLLVSDKAPGPELELALKSAELWRELAERLPPGIEYEPKGGLVVASDEAALTALRT
                     FAAAQEKAGVTVRDVAADRLPDLEPHLARGLAGGVHYPQDAQVMPALAATHLLRASGAE
                     VRLGQEVTGLLTGPGGAIRGVRTASDVFHAPYVVNAAGTWGGELARLAGVLLPVLPRRG
                     FVLVTEPLPRVVRHKVYAADYVADVASDSATLQTSAVVEGTPAGPVLIGASRERVGFDR
                     ALSVPALRRLAAGATALFPVLAGVRVIRTYAGFRPYLPDHLPAIGTDARVPGLLHACGH
                     EGAGIGLAPVTGRIIADCLTGAQPPLDIAPFDPARFEGGTGAGAGA"
     gene            29019..29333
                     /db_xref="GeneID:96295012"
                     /locus_tag="IE233_RS35095"
                     /old_locus_tag="GCM10010326_71530"
     CDS             29019..29333
                     /codon_start=1
                     /db_xref="GeneID:96295012"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237883.1"
                     /locus_tag="IE233_RS35095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71530"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_190029296.1"
                     /sec_met_domain="Fer2_4 (E-value: 1.2e-27, bitscore: 88.8,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARTPGELAGARPGPAFEITVDGRAVSALPGQTVAAALWAAGVLT
                     WRTTRGGGSPRGVFCGIGQCFDCLVTVNGVANRRACLVAVGPGDEVRTQEGEGRGELAV
                     "
     gene            29541..30965
                     /db_xref="GeneID:96295013"
                     /locus_tag="IE233_RS35100"
                     /old_locus_tag="GCM10010326_71540"
     CDS             29541..30965
                     /codon_start=1
                     /db_xref="GeneID:96295013"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038323.1"
                     /locus_tag="IE233_RS35100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71540"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_229893048.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.8e-21, bitscore:
                     67.5, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 2.2e-13, bitscore:
                     43.5, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDLVVVGAGPAGLAGAGTAGELGLRVALLDMAEHVGGQFYRQPA
                     AGLGAARPEALHHDWDAFVALRKRLAAGRVEHLGRHHVWAVERGGDGDWAVHAVVGDDG
                     GEGRPVRVRARAVLLATGAYERQLPFAGWTLPGVVGAGGAQAMLKGGLVLPGKRVVVAG
                     SGPLLLAVASSLASAGAEVPAVIEASGYLGYARHPRALAVNPRKLAEGLTHGAALLRHR
                     IALRTRSAVTEAHGSERVEAVTVSRLDARWRPVPGSGRRIACDALAVGHGLVPGIELGT
                     TLGCGTRTTADNTLALHLGSGQETSVRGVWGAGEVGGVAGAQLARIEGELAARSIAARL
                     GRDPGPEGRVRQLSSRRTRLRTFAEAMAATHAPGPGWTGWLSDDTEVCRCEEVTAGRVR
                     EAVADQGARDARTVKLFTRAGMGWCQGRMCGAAVSCLAGDGQPPAQRRPLAVPLTLGAL
                     AGQGPEDASEPSQSQT"
     misc_feature    complement(30967..30977)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            31013..31720
                     /db_xref="GeneID:96295014"
                     /locus_tag="IE233_RS35105"
                     /old_locus_tag="GCM10010326_71550"
     CDS             31013..31720
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295014"
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938955.1"
                     /locus_tag="IE233_RS35105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71550"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_161249621.1"
                     /transl_table=11
                     /translation="MGHLKQSKVITTTERLRDQVAHALRAALISGELRPGQVYSAPGLA
                     EEFGISATPVREAMLDLAREGLVEPVRNKGFRITEVNERDLDQYTEIRALIEVPMIGRI
                     TRSADRADLEALRPVAEEIVRAARDHDLIGYLEADRRFHLSLLALSGNERLVETVGDLR
                     KRSRLYGLTALDQRDELIPSAEEHIELLDLMLAGDARAAEKCMTRHLGHVRSLWARSEA
                     AEPKPKRRLGAAR"
     gene            complement(31826..32161)
                     /db_xref="GeneID:96295015"
                     /locus_tag="IE233_RS35110"
                     /old_locus_tag="GCM10010326_71560"
     CDS             complement(31826..32161)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047013.1"
                     /locus_tag="IE233_RS35110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71560"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_190029298.1"
                     /transl_table=11
                     /translation="MTADSPLTGRLDDDDYPAYTMGRAAEMIGASPGFLRALGEARLIT
                     PLRSEGGHRRYSRYQLRIAARARELVDQGTPVEAACRIVILEDQLEEAQRLNAEYRAAA
                     DKDPGSR"
     misc_feature    32156..32166
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(32361..32669)
                     /db_xref="GeneID:96295016"
                     /locus_tag="IE233_RS35115"
                     /old_locus_tag="GCM10010326_71570"
     CDS             complement(32361..32669)
                     /codon_start=1
                     /db_xref="GeneID:96295016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964502.1"
                     /locus_tag="IE233_RS35115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71570"
                     /product="SCO5918 family protein"
                     /protein_id="WP_167158692.1"
                     /transl_table=11
                     /translation="MRCVIARFPFDLSKAQVVAAMKGIKPEPVEGDSVLIGRRHYPVKQ
                     VGEVITRQDRRDFSAQEVTRAMTRLGFTCQGLPQAAPARTLTPLEAASEMLGVSALA"
     gene            complement(32759..34309)
                     /db_xref="GeneID:96295017"
                     /locus_tag="IE233_RS35120"
                     /old_locus_tag="GCM10010326_71580"
     CDS             complement(32759..34309)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295017"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310807.1"
                     /locus_tag="IE233_RS35120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71580"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_190029299.1"
                     /transl_table=11
                     /translation="MNRTRTNDRYSRTNNSGGSGAPRGGSRFGSSGSSGGSGRFGSSGR
                     SGSSGRSGGYGRRSSGPQGEFALPVTITPALPAVEAFAELALPPQLLAELAQQGLSVPF
                     PIQGATLPNSLAGRDVLGRGRTGSGKTLAFGLAMLTRTAGRRAEPRQPLALVLVPTREL
                     AQQVTDALTPYARALRLRLATVVGGMSIGRQAGALRSGAEVVVATPGRLKDLIERRDCR
                     LDQVDITVLDEADQMADMGFMPQVTELLDQVRPGGQRMLFSATLDRNVDLLVRRYLSDP
                     VVHSVDPSAGAVTTMEHHVLHVQSADKYATTTEIAARDGRVIMFLDTKHAVDQLTKHLL
                     QSGVRAAALHGGKSQPQRTRTLAQFKTGDVSVLVATNVAARGIHVDNLDLVVNVDPPTD
                     HKDYLHRGGRTARAGESGSVVTLVTPNQRREMSRLMVNASIVPQTTQVRSGDEELSRIT
                     GAQAPSGIPVTIKAPVVERPRRSASASSSRGRRSRPSQDRRAARPARAAEPRQSGTAA"
     gene            complement(34708..34911)
                     /db_xref="GeneID:96295018"
                     /locus_tag="IE233_RS35125"
                     /old_locus_tag="GCM10010326_71590"
     CDS             complement(34708..34911)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96295018"
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125862.1"
                     /locus_tag="IE233_RS35125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_71590"
                     /product="cold-shock protein"
                     /protein_id="WP_031141049.1"
                     /transl_table=11
                     /translation="MAAGTVKWFNAEKGFGFIEQDGGGPDVFAHYSNIAAQGFRELQEG
                     QKVNFDIAQGQKGPTAENIVPA"
     misc_feature    34955..34975
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.8"
                     /tool="antismash"
     misc_feature    complement(34995..35009)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.13"
                     /tool="antismash"
ORIGIN
        1 cccgagcgtt cggcgtcccg gcatccgttg ttccaggtca tgctcaccgt cggcgacacc
       61 gctgccggcg ctccggatct ggctggcctc gaagcggcct tcctggagcc ggagttgagg
      121 atcgcgaagt tcgacctgac cttcgcgttc ggtgagcgcc gggccgccga cggcagcccg
      181 gacggtctcg acatcatcgt cgagtacgcc accgacctgt acgagccgaa gacggtcgga
      241 ctcctgctgg agcgcatcct gctcctgctg gagtcggccg cggccgaccc cgacaccgcc
      301 gtcggctcga tcctgctgct cgcacccgag gaacggcatc tcctcgacgt ctggtccggt
      361 cccgccaccc aggcgcccga actgggcttg gacggcttgt tcgcgggtca ggcggcgcgt
      421 tcgccggagg ctccggctgt ggtgtttgag gatcaggtgg tgtcgtacgg ggagttggag
      481 gtgtggtcga accgtctggc gcggtatctg tcgggcaagg gtgtgcggcc gggtgatctg
      541 gtggcggtgc atgtggagcg ttcgccgcac atggtggcgg cgatcctggc ggtgttgaag
      601 gcgggtgcgg gttacacgat gttggatccg cagttcccgg aggagcgtct gaatgctgtt
      661 ctggggcagg tgcgtccggc tgttgttgtc acgcagtcgc atcttccggt gttgcggtcg
      721 gatgcggtgc gggtcgatct gacgcgtgag gtggcggaga tcagtgccgt ctcgggtggg
      781 gcggtgggga cgggtgggtc tccggagtcg gttgcgtgtg tgatgttcac gtccggttcg
      841 acgggtgtgc cgaagggtgt tgccgcctca caccgggcgc ttgcggcgac gtttgtcggt
      901 cctgactatc tggcgttcgg tccggagcag acgttcttgc agtgttctcc ggtgtcgtgg
      961 gatgcgttcg cgctggaggt cttcggtccg ctgcttcatg gtggggtgtg tgtgcttcag
     1021 ccgggtcagc acactgatcc gcatcagatc gtggagctgg tggagcggca tcaggtgacg
     1081 acgctgcaga tgtcggcgag tctgttcaac cacatgctgg acgaacaccc cgccgtcttc
     1141 ggccagatcc gtgaagccat gacggctggt gaagctgcgt caccctccca cgccgcaaag
     1201 gcacttgctc gcttcccgca cctgcggttg ctgaacgggt acgggccggc ggagagcatg
     1261 ggcttcacga ccacgttcac catcgagccg ggtatggccg agggcgtggc gagcattccg
     1321 gtgggtggtc cactgtctgg gaagcacgcc tatgtgctcg acgcgaacct ggagttggtg
     1381 gcgccgggcg tgccgggtga gttgtacgtg tccgggcatg gtctggcgca cggatacatc
     1441 gggcagccgg gtctgtcggc ggatcgattc gtggccaacc cttacggctt ggccggggcg
     1501 cggatgtatc gcacgggcga cttggcgcgt tggaacaagc agggtgcgct ggagtatctc
     1561 ggccggggtg atcagcagat caagctgcgg ggcttccgga tcgaaccggg cgagatcgag
     1621 gcggcgttgg cctcgcatcc gcaggtgcag caggcggcgg cggtggtccg tgaggaccgt
     1681 cccggtgaca agcgcctggt tgcctacgtc gtggccgaca cgaccgatac ggcggctctg
     1741 gtgcggcaca ccgcggcgcg gctgccggag tacatggtcc ctgcggccgt cgtggtcctg
     1801 gaggagttgc cgcgtacggt caacggcaag ctcgaccgtc gtgccctgcc cgcgccggat
     1861 ctgtccgctg tgtccgacgg tcgtgccccg cggaatccgg ccgaggagat cctgtgcggt
     1921 ctcttcgccg acaccctcgg gctcgcttcc gtcaccatcg acgaccactt cttccaccgc
     1981 ggcggccact ccctgctcgc cacccggctg atcagccgca tccgtacggt ctggggcacc
     2041 cgcgtcacca tccgcgacct gttccagagc cccaccccgg cactgctggc cgagcacatc
     2101 gcggcgggca gcggaagcaa cccgctcgac accgtgctgc ccatcagggc acccggccgg
     2161 gacacggaca cggcgccgct gttctgcgtg cacgccgtct ccggggtgag ctggggctac
     2221 gccgggctgc tgccgcacct cggtgccgac cggccgctcg tcgccctcca ggcccgtcgg
     2281 ctcggcggta ccgaggacgc gccggaatcc atcgaggaga tggcggacga ctacctcgcc
     2341 gagatccgca aggtccagcc gcacggcccg taccacctgc tcggctggtc gttcggcggg
     2401 ctcgtagcgc acgcggtcgc cgcccgtctg gaggcggccg gggaggaggt cgcgctgctg
     2461 gcgctgctcg actcctaccc gctgcccgac gggttccggg cgcccgagat cgacggcagg
     2521 cacgtactga ccgccctgct cggcagccgg ggcgagtccg tgccggtgcg gtgtgccgac
     2581 tcggtgccgg acatcgccga actcgccgag gcgctgcggc agtcggaccc cgtgctcgcc
     2641 ggtctggagc acacacaggc ggcggccgtg gtggcggcga ccctcgacaa cctgcggatg
     2701 cggtaccggt acgtgccgga cgtccggttc ggcggtgacg cactgttctt cgacgcgacc
     2761 ggcacgccgg cggcgcagtc gggggcggcg gcctgggccc cgtatgtcgg gggccgggtc
     2821 gaggagttcg cggtagactg cgagcacgcg gcgatgaccg aggcggagcc gctgcgcgcg
     2881 gtcggggagg tgctcgcccg ccgtctgcgg ccggcggccc acatctgaga cagcgcctcg
     2941 tccgggacgg ccgcctcgcc cgagacggcg cgtcgcccga gacgcggcac acggcaggcg
     3001 acacgggaca tgcggcacac ggccccgggg cccgtacggc ggatttgatc gccgtacggg
     3061 ccccggggtc tgtccgggtc tgcgctccgc accgcttccc gcggccccgg ctgccgctaa
     3121 ctgcccgcat actgccgctt cggcagccgg attcgggtgc cggtgttgcc tagcgtggag
     3181 gggtccgcat gatcggcctg gcccagtgaa cggtccggtc cggcccccag aggaagtcaa
     3241 ggacatggtg gatcattccg gttggcgcgt cggcgtcgct tccgcgccga tacatcacgg
     3301 cgaaatactc cagggcgtct ttccgcacca gggtcagctc agccgggggc tggtcacgat
     3361 gccctgtacc gtccacacca cccaggcgtc cttcatcccc gcccggggcg aggagctgac
     3421 cgtctccccg tcctggaagt ccaaggcgcg gcgggcggcg cagctcgccg tccaggcctg
     3481 tgtgcggccc gaggacgggc cggtcggcgg gcatctcgaa ctgaccggcg acgtgccgct
     3541 gtgccgtggc ttcggctcct cgaccagtga cgtgctggcc gcgatctggg ccgtgcagga
     3601 cgccttcgtg gcgccgctgc cgcccgaggc cgtcgcgcgg atcgcggtgt gtgccgagac
     3661 cgcgtccgac tccctcatgt tcaaggagag ctcggtgctg ttcgcgcagc gcgagggcaa
     3721 ggtcatcgag gacttcggct accggatgcc ggccgtgcgg gtcctcggct tcggctcccg
     3781 gccggagaac gaaggcaagg gcatcgacac cctggccttc ccgccggccc gctacgacag
     3841 cacggagatc gaggacttcg ccgagctgca cgcgatgctg cgcgaggcca tccacaccaa
     3901 ggacgtcgcc ctggtcggcg cggtggcctc ggccagcacc gcgatcaacc agcggcacct
     3961 gcccatcccg ctcctggaca gcctgcgcgt catcgagcgg gagaccggag ccctcggcat
     4021 tcagaccgcg cacagcgggg acatcgccgg actcctctac gaccgcgacg accccgaggt
     4081 cgacgcccgc accgagcacg gccggcgact gctgcacaac atcggcatcc acgagcagtg
     4141 gatcttcacg acgggtgact gacatgacca ctttcacgat cgcgggcgcc gcgcgggtgc
     4201 acgactcggt ggtggacgcc accgagctgc cccgcatcat ccaggtgacc gacaacctct
     4261 acgccaccgc gttcagcctg atgaagctgc tgccggcgcg gttcatcgtc gaccgtgcgg
     4321 aggccgcggg cctgctgcgg cccggcaccc ggatcatcga gacctcgtcg ggcaccttcg
     4381 cgctcggcct ggcgatggtg tgccggctgc gcggctacga cctgaccatc gtcggtgact
     4441 ccgcgataga ccgggacctg cgcaacaggc tcgaaatgct gggcgccacc gtcgagatcg
     4501 tcgagcacac cggccagccc ggcggcatcc agggtgcccg gctggcccgc gtggaggaac
     4561 tgcgccggct gcaccccgac agcttcgtcc ccgggcagta cgacaacccg gacaaccccg
     4621 gcgcctacgc ggtcgtcgcc cagctcatcg gggagaccgt cggttcggtg gactgcctgg
     4681 tcggcccggt cggctccggc ggctccaccg gtgggctcgc cgccgccctg cgccccaccg
     4741 acccggccct gcacctggtc ggcgtcgaca cccacggctc gatcatcttc ggcacccccg
     4801 acgggccgcg caccctgcgc ggcctcggca gcagcatcca cccgggcaac gtgcgccacg
     4861 ccgcctacga cgaggtccac tgggtcaccg cggccgaggc cttccacgcc acccacgaac
     4921 tgttccgcaa ccacggcctg ttcatgggcc cgaccagcgg cgcctccttc caggtcgcgt
     4981 cctggtgggc ggcgcggaac cccgagagca aggtcgtcat ggtgctgccc gacgagggct
     5041 accgctacca gtcgaccgtc tacaacaccg actggctgac cgcgcagggc atcgaaccgg
     5101 cccccacccc gggcggtccc gtgaccgtcg cgcacccgct ggacgccccg gagtcctggt
     5161 cccgtctggt ctgggcgcgg cgcggattcg acgacgtgat gatgccgggg gccgacgcat
     5221 gagcgccccg ctgctgctgt tcgtcgagtc caacaccacc ggtacggggc gccagttcgc
     5281 gcagcgggcg cgcgctttcg gtgccgagcc ggtgctgctg agcgccgacc ccggccgcta
     5341 cccgtacgcg gccgatgacg agctgcgcac ggtcgtcgtg gacaccgcgg acggtgacgc
     5401 cctgtgggcc gccgtccagc ggctcgccgc cggtgcgcgc gtcgccggtg tgctgtccag
     5461 ctccgagtac tacgtggccg ccgccgccga cctggcggcg cggctcgggc tgcccgggcc
     5521 gtccgccgac gcggtgcgtg cctgccggga caagtcggtg cagcgccgca gcctggccga
     5581 tgcgggtgtg cccgtccccc ggttctcggt ggccggcacg gtcgccgacg cggtcgccgc
     5641 cgcgcagtgg cagggcggcc cggtggtggt caagccggtg cagggctccg gcagcctggg
     5701 cgtacgcctg tgccgcgaca gcggtgaagt cgtcgcccac gccggggagt tgctgtccgc
     5761 gacggtcaac gagcgcgggc tgcgcacgcc cgcccgggtc ctggtggagc agtacctcac
     5821 cggggccgag ttctccgtcg aggtgttcgg cgagcacgcc gtggtgaccg tcgccaagca
     5881 cgtcggcgaa ccgccggtct tcgtggagac cggccacgac gtgccggccg tgctgcccgc
     5941 gcccgaggcc gccgcactgg ccgacagcgc cgtgcacgcc gtgaaggcgc tcggcctcgg
     6001 ctggggcgcc gcccatgtcg agctccgcct cgacggcggc gtggcccgtg tcatcgaggt
     6061 caacccgcgc ctggccggcg gcatgatccc ggaactggtg cgccgcgccc ggggcatcga
     6121 cctcgtcggc gcccaggtgc gtgccgggct cggcctgccc gtcgacctca tcggcacgag
     6181 cggcaccgtg ggagcggcct ccatccggtt cctcaccgcg gacggcgacg ccgtcctcgg
     6241 ggacaccgac gccgccgagg ccgccgccct cgccgtgccc ggtgccgtgg acgccgccct
     6301 ctaccgcccg cccggcaccc gggtcgggcc ggccgaggac ttccgcggcc ggctcggcca
     6361 cgtcatcgcc gtcgccgacc gccccgagga gtcggcgcgc gcggccgaca ccgcccgctc
     6421 cctcggactg gccaccgccc tggaacacgc cccggtgaag gaggagatgc cggtatgacg
     6481 actccttcgc aggccgtcgg cgccggggga gtggacaccg ggcggctgcg caccgctctg
     6541 gacgcccgcg cccaccgcat cgtctacgac cagtaccggc ccggcgccga cgacccgatc
     6601 gggcaggagc tgcggctgat cagcgaggtg gaccgggccc acctggtcat gctcgccgag
     6661 cgcggcatcg tggacaccgc ccgcgccggg gcgctcctcg gcaccatcga caccctgcgc
     6721 gccgacgact tcgcggccgt ccgggaccgc cccatgccgc gcgggctgta tctggcgtac
     6781 gagggctggc tcgtggaccg gctcggccag gagaccggcg gcgtgctgca caccggccgc
     6841 tcccgcaacg acctcaacgc caccaccgta cggctgcggg tacgcggccc ctacggccaa
     6901 ctggtctccg aggtactgga gttggcggag gtcctgctcg accgggccga gcggtaccgg
     6961 gacgtcacca tgcccgccta cacgcacggc cagcccgcgg tgccgatcag ctacgggcac
     7021 tacctgtgcg gggtcgccgg cgcggtcctg cgctcggcgg aggcactgct cgacgcgggg
     7081 cgcgagatcg acgtcaaccc gctcggcgcg ggcgccgtcg gcggcacctc cgtgcccgtc
     7141 gaccccggcc gcaccggcga actcctcggt ttcaccgggg tggccccgaa ctcggtcgac
     7201 gccgtcgcct cccgtgactt cgcgctgcgc atgctgtcgg ccgcggccgt gctgggtgtc
     7261 ctcatggccc ggatcgcccg cgacctgacc tggtggacca ccgaggagtt cgggctgctg
     7321 cggatggccg acgacctggt cggttccagt tcgatgatgc cgcagaagcg caaccccttc
     7381 ctgctggagc acgtccaggg ccgttccagt gccgcgctgg ccggtttcac gggtgccgcc
     7441 accgccatgt ccaccgccgg ctacaccaac gccatcgccg tcggcaccga ggccgtacgg
     7501 cacctgtggc ccggcctcgc cgggaccgag gaggcggcga ccctgctgcg gctcgtcgtc
     7561 gccggcgccg aacccgatcg cgcgcgcatg acggcccggg cccgggacgg cttcacctcc
     7621 gccacctacc tcgccgaacg cctcgtcgtg gacggcatgc ccttccgcac cgcccaccac
     7681 ctcgtcggcg agaccgtcct cgccgccctg gacggcggcc tcccgctgtc cgaggcggcc
     7741 cgcgcacagc ccgccgtcgc cgaggccgcc gccggatacc ccgcggactg gctcgacccg
     7801 gagaccgtcg ccgccgcctg cgcccacggc gggggacccg gcggcgccgc gcccgacgcc
     7861 gccctgaccc gggcccgcac ggaactcgcc gccgccaggc gggagttcgg ggaccgccgg
     7921 gcacgctggg ccgacgccgc cgaccggctg accgacgagg tggccaaggt gatgacggtc
     7981 cgatgaacac cgccaccgcc gccccgccac ggccgcgtgg cggactcctg ggccaacggg
     8041 acttccggct gctgtgggcg ggcgagacca tgagccggtt cggcagcaac atcaccggtg
     8101 tggccatgcc gctggccgcc gtcgtcagcc tcgacgcgag caccttctgg gtgagcgcgc
     8161 tggccgccgc cgcctggctg ccctggctgc tggtcggcct gcccgccggg gcctgggtgg
     8221 accggctgcc gcgccgcccg ctgatgctgg tctgcaacct gggctcgctc gtgctgctgg
     8281 ccagcgtgcc cgcggcggcc tggctggacg tcctgaccat gacccagctc atggtggtcg
     8341 cgctgctcac cgggctcgcg aacgtgttct tctccatcgc ctaccgcgtc tacctgccct
     8401 ccgtcgtccg ccgcgaggac ctcgccgagg ccaacgccaa actccagggc agcgagtcgg
     8461 cggcccagct cgccgggctc ggcggcggcg gcatgctggc cgggctgttc ggcgcggtca
     8521 gcggtctcct cgtcgacgcc gggaccttcc tcgcctccac cctgtgcctg ctcggcatcc
     8581 gcagcaccga accccgcccc gaggcgccgg ccgtgccccg gccgctgcgc caggaggtgc
     8641 gtgacggcct gcactacacg ctgcgcgatc cctacctgcg cgtcctcacc gcctacggca
     8701 ccgtcaccaa cctgctgctc accggttacc aggccctcct caccgtcttc ctggtccgtg
     8761 acctgggcgt cggcgcgtcc gcggtgggct ggctgctcgc cggtgccagc gtcggggggc
     8821 tgctcggcgc cgtcgtcgcg gggtccctgt cgcggcggtt cggctccgcc cgcggcatgc
     8881 tgctgtgcaa gttcgccacc gcgccgttcg gcctgctcgt accgctggcc gaacccgggt
     8941 ggcgggtcgt cctgctcgcc ctcggcgggg cggtgctcgc cctgggcgtg gtgtccgcca
     9001 acgtcatcca gggcacgttc cgtcagcagt actgcccgcc gcacctgctg ggccggatca
     9061 cggcgagcat gtcggtcgcc aacttcggtg ccattcccgt gggttcgctc ctcggcggca
     9121 tcctgggcag cgctctgggc gtgcggcccg cgctgtggat gctcaccggc ggcctcgcgg
     9181 tcagctccgc gctgctgctg gccggaccgc tgcgcgcccg ccgcgacctg ccgatcgaac
     9241 caccgctccc agaaggggag ttgaggtgtt ccgcctcgcc gccggcgcgc acgtcgccgg
     9301 gtgcggagcg ggatgcctcc gacggcggtc cgcgccgtca tccatcagga agaggtcggt
     9361 gagtgaccca tgagcggttc tccgtccgcg agcgccaccc tgctccaccc ggcggctcca
     9421 ccgggacggc ccctgcccca gcccggctcc ctggacctct atctcatcag ggtcccggac
     9481 atccgcggcg ccgccctcga caccgcggta ctggacccga ccgaacggca tcgcgccgcc
     9541 gaactggcgc acgccgacga ccggatccgc ttcaccacgg cccatctggc gctgcgccga
     9601 ctgctcggca cctatctcga cacccggccg caggacatcc gctacggccg cgagacctgc
     9661 ccgtgctgcg gcggtccgca cggccggccc accgtgctgg gcgcgagccg cgaactgcac
     9721 ttctcgctct cgcaccgggg cgacctggtg ctcatgggaa cggcggtggc ccccatcggc
     9781 gtggacgtgg acctgatcac cgaccccggc agcgccgccg aactcgccgc gatgctgcac
     9841 ccggccgaac aggcggagat cgcggccctg ccacccgtcc gccgccctcg cgaactggct
     9901 cgcctctgga cccgtaagga ggcctacctc aagggtctcg gcaccggcct cggccgtgac
     9961 ccggcggccg actacgtggg ctccggcagc tcgaacggcc cctgcccgcc gcccggttgg
    10021 accgtcctcg acatccccgt ggaccgcggc tacgcggcgg ccgtggccgt ccacggcgcc
    10081 ttgacgatcg cggcgccccg cgtcaaccgg ctctcggacc acgacatccg cgacggcccg
    10141 cccggcggca cgggaaggcg ctgacaccgc ccccggatgc cgtccggggg cggtcagcac
    10201 ctcgccgtgc cggttcagtc gcggcggcgg cgcaggagga ggaagccgcc gcccgccacg
    10261 ccggcggcgg aggccgcggc cagggcctgg ggggcggccg aaccgccggt ggaggcggag
    10321 gaggcggccg gggcggccgc gggggtggtg gcggtcacgg ggtcgccgcc gtggccgtgg
    10381 tggctcaccg tggagtgggc ggctcccgcg gtgatcttct gctcggtcgg cgccgcggcg
    10441 gccttcgcgg cgccgccgta caccacgtcc gagcagctgt agaacgcctc cgggctgtcg
    10501 tcgcgctgcc agaccttgta gatgatgtgg cggccggtgc gggccggcag cgtaccggtg
    10561 aagttgtagt agccgtccgt cgcggtgcgc ggggtctggt aggtggccac gggggtgttg
    10621 tccaggtcgg accacttcag cggcttcgtc gggtcgaagc cctgcttggt gatgtagacg
    10681 gtcatcgtgc ccgaatgggc ggccgtggca cggaacttga agtcgaactt gcccgccgcg
    10741 acgccggtgg acggccagtc ggtacgggcc cagtccagcg cacggtactt gtcgcggttc
    10801 gccgagcaca gtttgccgtc ggggatgagc tggcgggact ggccgttggc gttggcgatg
    10861 ttcacctcgt tccagtcgta cagcggctgc gtgcccgagt cggccacgag gtccttgcac
    10921 acctgcgaca ccggatgctc cgggccctcg gcgtagcagg cggcgatccg gctgaccggg
    10981 ttgaacatgg ccccgtgcgc ggaggcggcg gtgggggtga ggcagaggag cgtcagggag
    11041 gtggccccga ggacacccag ggacgctgcg gtgcggcgag cggacatgcg agtgctcctt
    11101 gatcgtgggg aggcgggcgc ccacggcggc cgtgccgtcg cggcccgcgg cagggcagga
    11161 cggagcacgg gcgcgccaag tcgcccttgg gtagcggtac ttggcagact ggcattggtc
    11221 tggaccaagc cgcaagaggg ctacgcctac cggtcgggcg tcgtgcggtc gccatcccgc
    11281 ggccggccgc acaaggcccg caggcggagg cgggttcgag gggtgcgggg aaccgcgggc
    11341 ggggccgcgg agggcgggcc acccggggcg ggaggggcgc gggcccggac agtagagtgc
    11401 gggtccagac gccgcccgac ctccgaggta tccgtgaacc acccccgcac cccgcacccc
    11461 gacgtcaccg tcgtcggcat cggggccgat ggatggggcg ggctcggggg cgccgcccgg
    11521 gcggtgctcg gggccgccga ggtggtcgtg ggaggggcac ggcagctcgc gctcctgccg
    11581 aaggacgcgt gccgcgggga gcgcgtcgcc tggccctcgc cactgcggcc cgcggtgccg
    11641 gagctgatcg cggcccacgc cgggcgccgc atcgccgtcc tggccagtgg tgaccccatg
    11701 ttctacggga tcggccgcac cctcaccgag gtgctcggca ccccgctccg cgtcctcccg
    11761 cacccctcat ccgtcgccta cgcctgcgcc cggctcggct ggtccgtgga ggagaccgaa
    11821 gtcgtgaccg ccgtcgggcg gcccctcgcc cgggtcgcgg ccgccctgca ccgcggccgg
    11881 cgcctgctgg tgctcagcgc cggcgccggc acccccgccg aggtcgccgc cctgctgtgc
    11941 gaccgcgggt tcgggcccag ccggatgtgg gtgctcgacc agctcgggtc cgaggacgag
    12001 cagtgccggg acggcgtcgc cgaggcctgg gacgagcccg cccacgacgc gctcaacgtc
    12061 gtcgccgtcg actgccgccg cgcccccggc gccctccggc tcggtgccgt gccgggtctg
    12121 cccgacgcgg cgtacgagca cgacgggcag ctcaccaagc ggcacgtccg cgccgccacg
    12181 ctcggcgcgc tcgcgcccgc gcccggcgaa ctgctctggg acatcggcgg gggctccggc
    12241 tcgatcgccg tggagtggat gcgtacgcac ccgtcctgcc gggccttcag cgtcgagcgg
    12301 gacccggttc gcgccgaccg catccggcgc aatgccgagc ggctcggtgt gcccggcctc
    12361 ggggtggtcc tcggcggtgc gcccggtgcg ctcggtcaac tcccgccccc cgacgccgtg
    12421 ttcatcggcg gcgggctcac tgcgcccggg ctgctggacg cctgctggga cgcgctgccc
    12481 gtcggcgggc ggctcgtcgc caacaccgtc acgctcgagt ccgaggcgct gctcgccgag
    12541 tgctaccggc gccacggcgg cgacctcgtc cggctcgccg tcgcgcacgc cgtgccggtc
    12601 ggcaccttca cgggctggcg ccaggccatg ccggtcaccc agtgggcggt ggccaaggcc
    12661 ggacccgccc ccctcaacac ctctccagga gacgacagat gaccgtgtac ttcatcggcg
    12721 cggggcccgg tgccgccgac ctgatcacgg tgcgcggcgc ccgtacgctc gcctcctgcc
    12781 gggtctgcct gtacgcgggc agcctggtgc cgcgcgaact gctcgcggag tgccccgacg
    12841 gcgcccgtct cgtcgacacc gcgcagctcg acctggatga gatcaccggg gagctggtgc
    12901 gcgcccacga ggcgggccac gacgtggcgc ggctgcattc gggcgacccg tcggtgttca
    12961 gcgcggtcgc cgagcagatg cggcgcctgg acgcggccgg ggtgccctac gaggtcgtgc
    13021 cgggggtgcc cgcgttcgcc gcggcggcgg ccgccctcaa gcgggagctc accgtgccga
    13081 ccgtgggcca gaccgtcatc ctgacccgcg tcgcgcagcg cgccaccgcc atgcccgagg
    13141 gcgaggacct cgcgaccctc gggcgcagcg gcgctctgct cgtgctgcac ctcgccaccg
    13201 ggtacgtcga ccgtgtcgtc gaagagctgc tgccgcacta cggggccgac tgccccgcgg
    13261 ccgtcgtcgc cttcgcctca cggcccgagg aggtcgtgct gcgcggcacc ctgtccgaca
    13321 tcgcgggaca ggtgaaggac gccgggatcg tgcggaccgc cgtcatcctg gtggggcgga
    13381 cgctgggcgc ggccgagttc cgggacagcc atctgtactc cgccgaccgc caccgctgtt
    13441 gaggacgacg gctcacgggc ccgccggctc gctccggccc accacgttgc ccgcccggtc
    13501 gatgcagatc acgtccaccg tcaccggcgc cccgcgcagc acggacagcg cctcgtcgcg
    13561 ggcccgcgcg gccaccaggt cgcccagccg gacgcccgcc gctgtgcaca actgcagtgc
    13621 cgcgaggccc gtgttggcgt ccgccacctc ggccgcgagc gcctcgctcg cgccgccccg
    13681 gcgggcgagc tcggcgagga agggcttgtc cacctgggag cgggccgagt gcaggtcgag
    13741 atggcccgcg gccagcttcg acagcttggc gaagccgccg cagatggtga ggcggtccac
    13801 cggatgacgg cgtacgtact tgaggaccgc gcccgcgaag tcgcccatgt cgagcagggc
    13861 gtcctccggc aggccgtgtt ccgcgacgac cgtcttctcc gacgtcgagc ccgtgcagcc
    13921 cgccacatgg gtgcggcccg ccgcccgcgc cacgtccacc ccgcgccgga tcgagtcgat
    13981 ccaggccgag cacgagtacg gcacgacgat cccggtcgtg cccaggatgg acagaccgcc
    14041 caggatgccc aggcgcgggt tccaggtcga gcgggcgatc tccgcgccgt ggtccaccga
    14101 gatggtgatc tccacgtccc ccggggcgcc gtgccgttcg gccaccagcg ccacgtggtc
    14161 gcgcatcatc tggcgcggca ccgggttgat cgccggttcg cccaccggca gcggcagccc
    14221 ggggcgggtg atcgtgccca ccccttcgcc cgcccggaac accacgcccg agccgggcgg
    14281 aagcagccgt accgtcgagc ggaccagcgc gccgtgggtg acgtccgggt cgtcgcccgc
    14341 gtccttcacc accgccgcca tcgcatgacc ggcggcggcc ccccgcccgg cggccggctg
    14401 cgcgggggcc agttcctcgg cggccagcgc gaacgcgggg gtctggccgc gcggcagcgt
    14461 gatcgtcacc ggatcgggga agtcgccggt caggagcgcg gtgtacgcgg ccgtcgtggc
    14521 cgcggtcgcg caggcaccgg tcgtccagcc ggggcgcagc ccggtgtgct tgagttgggc
    14581 gccgcggcca cccttcgcct cactcacggt cactcacgga actcatggcc ctcggcctca
    14641 ctcacgaacg gaacccgatc ctgtgcacgt cttgattctg gggggtacgg gcgaggcccg
    14701 tcggctggcg gggctgctgt gcgacgccgg agtcacctca ctgcgcgtga cgagttcgct
    14761 cgccggacgg gtcgcggagc cccggctgcc gcccggcgag gtccgcgtcg gcgggttcgg
    14821 cgggcccgag gggctcgccg cgtggctgcg tgcgcacgcg gtggacgcgc tcatcgacgc
    14881 cacccaccct ttcgccggga cgatcagttt caacgcggcg cgggccgccg ccgaggccca
    14941 tgttcccctg ctcgcgctgc gccggcccgg ctgggtcccc ggcgcgggcg accgctggca
    15001 tccggcgggc tccctggagg aggccgccgc cctgctgccc gcgctcggcc gccgcgtctt
    15061 cctcaccacc ggacgcatgg gcctggcggc cttcgcccgt ctcgacgcgc tgtggttcct
    15121 catgcggtcc gtggacgcgc ccgagccgcc cttcccggcc gcgatggagg tgctgctcga
    15181 ccgcggtccc ttcaccctcg aaggggagcg ggaggtgctg cggacgcacc ggatagacgt
    15241 cctcgtcacc aaggacagcg ggggcgcggc caccgctccc aagctcgccg ccgcccgcga
    15301 ggcggggatt cccgtcgtcg tggtgcgccg gccgcccgtg ccggacgggg tcgagcgggc
    15361 ggccaccccc gaggaggcgg ccgcctgggt gcgccggttc accgggtgac cccgtccgga
    15421 cggtcggtgg ctcagccctc cgggtagcgg cgcggggtcc agacgatctc ctcgccgtcg
    15481 ccgcgccgga ccgtgcgggt ctgcgacgag ccgacgagca ggatcgtgcg catgtcgacc
    15541 tcggccgggt ccagatcggt caggcgcacg atgcggaccc gctcggtggg gccgcccacg
    15601 tcccgggcga ccacgaccgg ggtgtccggc aagcggtgct ccaggagcag ctcgcgcgcc
    15661 ttggcgacct gccaagtgcg gctcgcggag ccggggttgt agagcgcgag caccagatcg
    15721 gcggaggccg ccgcgtcaag ccgctccgcg atgacgtccc acggcttgag ccggtcggag
    15781 agcgagatcg tcgcgtagtc gtggccgagc ggggcgcccg cgcgggcggc ggccgcgttc
    15841 gccgcggtca cccccggcag gacccgcacg gggacctgcg cgtactcggg ctgcgaggcg
    15901 acttcgagta ccgcggtggc catcgcgaag atgcccgggt cgccgcccga caccacggca
    15961 acccgcctgc cccgcatggc cagttggagg gcgaactcgg cgcgctcgga ctccaccttg
    16021 ttgtccgagc cgtgccgcag ctgcccggga cgctccggca cccggtccac gtacgtggtg
    16081 tagccgacga tgtcgtcggc ggcggcgagg gcgccgcgcg actcgggggt cagccacagc
    16141 ggcccggccg gaccggtgcc gacgaccacg acctcgccgc gctcacgcac gggcggcgtg
    16201 gcgtcgatgc ggctcggcag caccgcgacg gagaagtacg gcaccgactc ggcctcgatg
    16261 tcggcgagcc ggcccgtgcg ctcgcccgcc atggtggcgc gctccacgta ccgcgcctcg
    16321 tccaggcgcc ccgaacgctc aagtgcccgg cggaccttgg tgaaggtgcg gcccagcttc
    16381 atcaccaccg ccgagtcggt ggcggccagc cgcgcggtga gctcctcctc cggcagcgtg
    16441 ccgggcagga tcgtgagcac ctcctcggcc tccaccaagg gctccccgag ccgggcggcc
    16501 gcggcgctca ccgacgtcac accggggatc acctcggtcg ggtagcggtg tgcgagccgc
    16561 ttgtgcatgt gctggtacga gccgtagaac agcgggtcgc cctcggcgag cacggcgacc
    16621 gtgcggcccg cgtcgaggtg ctcggccagg cgcgccgagg cctcctcgta gaagtcgttc
    16681 agggcgcccc ggtagccgcc gggatggtcg gtggtctcca cggtgagcgg gtagaccagc
    16741 ttctcctcga tgtggtcggc acggatgtgc ttcgccgcga tcgagcgcgc tatggaacgg
    16801 ccgtgccgcg ccgagtggta cgccaccacg tcggcctcgg cgatggcctc caccgcccgc
    16861 accgtcatca gggacgggtc gccgggcccg aggccgactc cgtagagacg gccggccgtg
    16921 ctgctgttct cgctcattcc gcctcgctcg cgatcgcgtt gagggcggcc gcggcgatcg
    16981 cgctgccgcc gcgccggccc cgtaccacca ggtgttccag gcccgagggg tgcgcggcga
    17041 gcgcgtcctt ggactcggcc gcgccgatga agccgaccgg tacgccgatg acggccgccg
    17101 gacggggggc gccctcctcg atcatttcga gcagccggaa cagggcggtg ggcgcgttgc
    17161 cgacggccac gaccgcgccg tcgagccggt cgcgccacag ctcaagggcg gcggcgctgc
    17221 gcgtggtgtt gagcttcgcg gcgaggtcgg gcaccgacgg gtcgttcagg gtgcacagca
    17281 cctcgttgtc ggcgggcagc cgcttgcggg tcaccccgct ggcgaccatc cgcgcgtcgc
    17341 acaggatcgg cgcgcccgcg cgcagcgcct cgcgggcccg ggccacgacg ccgggcgtcc
    17401 agccgaggtc gcgggtcagg tccgtcatgc cacaggcgtg gatcatgcgg accgcgacct
    17461 ggctcacgtc ggcgggcagc ccgccgaggt ccgcctcggc gcggatcgtg gcaaaggact
    17521 ggcggtatat ctccgcgccg tccttctcgt agtcgaacac tgtgctctcg ctcatctcgt
    17581 cgtggtcccc gtcgccggcg tgcccgttgt cgctttcctg tgtgtgccgg ctggtgcggc
    17641 gttcatcgtc cgccgcctcg cgcccggccg atggtgtccg ccaacttgcc ttctgcataa
    17701 ggcagttgct gctcggccat accgctccgg gccgtcaccg tgtagcggcc gtcggcggtc
    17761 gcggtcacgt ccacccagtc gccgtgcgga tgcccgcagc ggcgttcgca cccggaccag
    17821 tagaccggca ggccgccgct gcccggcagg gcgtcccggc ggacgtcggc cagcgccttg
    17881 gcgcagccgg gccgcccggt gcacgccccg accccgctcc acggggagcc ggggccggtg
    17941 atgaacccgg cggcgccgag ttcttccagc cgctcgtggg cgccgcgctc ctcgaagccg
    18001 gggacgacga atccgcgcca cggcgtgatc ctgacctcac cgccggggcc ggcgagcgcc
    18061 cgcagctgcg cgccggtcac ccggccgagc accggcgcca cgagtacggc gtacgtgccg
    18121 tcggggccgg gcgcgacgcc gggccgcggg gcgctcgcgg gcgccgtgtg cggtacgggg
    18181 gcgggctcgg ccgggatgcc cgcgctggcc agggcggcgg cgaggtccac ctcgtggccc
    18241 cggggcagct cgcgcacccg ccaggcgccg gtgcccgcgg cgtccgcggc ggcgaggaag
    18301 gcgcgggcgg cggcgagggc ggcgcggggg gcgtcggccg cggccacgcg caggggggcc
    18361 gcccctccgg tccggacgag cgccgcaccc tccccctgtg cgagcaaggt cacatcgccg
    18421 ccgaggccgg tgacgtcgcc gcggccgtcg tccagcgcga acagaaagcg ccccgacagg
    18481 gcggtggtcc agtcctgggc gcacagcagc gcgtccagct cgcgcagcca ggagtgcagg
    18541 ccaccgtggc cgaggccgtc caggccggcc agcggggacg ccacgatgtt gcgtacgcgc
    18601 tcgtgccgct cggagggcaa cagggcggtg tggcgcagga gttcggcgag gccgttgccg
    18661 cagtggtcac cgatgccgcg gagctcggcg ttgccgcgcg aggtgatgcc gaggtggccg
    18721 tccccgtacc gctcggccgc gacggccagc gcctccacct gacggttcgt caagatgccg
    18781 ccgggcaggc ggagtcgggc cagtttcccg tcgtcggcgg tgtgcagccg gagggcgccg
    18841 gggcaggcgt cgtcgcggtc ccgcacgacg gggccgggcg cgacttcgcc cggggtgccc
    18901 cctatggggg gttcgccctg gttggggggt gttgaggagg ggggcggcat ggcggcgagc
    18961 atacccaggg gggaggcggt ggccacgccg ggagtggtcc gggtgccggt cggctgccgg
    19021 ggcgccgccc ccgaccccgt tcgcgcctcg gcggcgcggg gctgtgacat gcgcggctcc
    19081 gccgcgtcca gccccgcacg gtccgcagcc gaacgcacac gagccgctcc ccgcccccgg
    19141 agggtccgca ccccccgggc cgcaggcccc cgcaccccca accaccccgc gcccaaaagc
    19201 gcgggcgacc ggggtagcta ctatgcaggc ggcgccggcg acggcggcag gggaggaagc
    19261 ccggtgggaa tccggcgcgg tcccgccact gtgagcccgg accgaggcca gctcggagac
    19321 cgggtgagtc aggaactccc cctcccaggc cggggaagcc tccccggctc gggggaccca
    19381 ttccgacacc acccggggcg cggacacccc gaggaaggcc tgacgccgca tgctgcacac
    19441 gtccggggag cccgcagagg acccccgccc catcctgctc ctgtcgacgt ccgacaccga
    19501 cctgctctcc gcccgcgcgg cgaacggccc ggtgccctac cggttcgcga acccgtcccg
    19561 cctcgcgctc gacaccctgc ccgcgctcct cgacggcgtc ggcctcgtcg tcgtacgcct
    19621 cctcggcggc gtgcgcgcct ggcaggacgg cctggaccag ctgaccgcga gcggcctgcc
    19681 cgtcgtcgtc ctgaccggcg aacaggcccc ggacgcccag ctgatggcgg cctccaccgt
    19741 gccggtcggc atcgccgcgg aggcgcacgc ctacctcgcg cacggcggcc ccgccaacct
    19801 cgaccagctc gcccggttcc tgtccgacac cgtgctgctc accggccacg gcttcgagcc
    19861 gcccgcgccc gccccgtcct ggggcccgct ggagcgcacc gcccggccgg tcgaggggcc
    19921 cgtcgtcgcg gtgctctact accgcgccca ccacatgagt ggaaacaccg ccttcgtgga
    19981 caccctgtgc ggcgcgatcg aggacgccgg gggccgcccg ctcccgctgt acgtgtcctc
    20041 gctgcgcgac cccgagcccg cgctcatcga cgagctgcgc gccgccgacg ccatcgtcac
    20101 caccgtcctc gcggccggcg gcaccaagcc ggccaccgcg tccgcgggcg gcgacgacga
    20161 atcctgggac gcgggcgcgc tcagcggcct ggacgtaccg atcctgcagg cgctctgcct
    20221 caccggctcg cgcagcgcct gggaggagaa cgacgagggc gtgtcgccgc tcgacgcggc
    20281 cagccagatc gccgtccccg agttcgacgg ccgcctgatc accgtgccgt tctccttcaa
    20341 ggagatcgac gccgacggcc tgcccgccta cgtcgccgac gccgagcgct ccgcccgcgc
    20401 cgccgggatc gcggtccgtc acgcccgcct caagcacatc ccggccgccg acaagcgcat
    20461 agcgctcgtg ctctccgcgt acccgaccaa gcactcccgc atcggcaacg ccgtcggcct
    20521 cgacaccccg gccagcgccg tcgcgctgct gcgccgactg cgcgccgagg gctacgactt
    20581 cggccccgag gacgagatcc cgggcctggt ctccggcgac ggcgacgagc tgatccgcgc
    20641 cctcatcgac gcgggcggcc acgaccagga ctggctcacc gaggagcagc tggccgccaa
    20701 ccccgtccgc atcccggccg ccgactacaa gcgctggtac gcgacgctgc ccgaggaact
    20761 gcgcacgaac gtcgagcagc actggggccc gccgcccggc gagatgttcc tcgaccgctc
    20821 ccgcaacccc gagggcgaca tcgtcctcgc ggccctgcgc cgcggcaacc tgctgatcct
    20881 catccagccg ccgcgcggct tcggcgagaa cccgatcgcg atctaccacg accccgatct
    20941 gccgccctcg caccactact tggcggccta ccgctggatc gcggcgagcg ccgccgacag
    21001 cggcttcggc gccgacgcga tgatccacct gggcaagcac ggcaacctgg agtggctgcc
    21061 cggcaagaac gcgggcctgt ccgccgcctg cggccccgac gccgcactcg gcgacctgcc
    21121 gctggtctac ccgttcctgg tcaacgaccc gggcgagggc acccaggcca agcgccgcgt
    21181 gcacgccacg ctcatcgacc acctcgtgcc gccgatggcc cgcgccgact cctacggaga
    21241 catcgcgcgc ctggagcaac tcctcgacga gcacgcccag atcgcgtcca tggaccccgc
    21301 caagctcccc gcgatccgcg cccagatctg gaccctgatc caggccgcga agctcgacca
    21361 cgacctcggg ctcgaagacc gccccgagga cgagggcttc gacgagttca tcatgcatct
    21421 cgacggctgg ctctgcgaga tcaaggacgt ccagatccgc gacggcctgc acgtcctcgg
    21481 caacgcaccg gccggcgccg accgcgtcaa cctcgtcctc gccatcctgc gcgcccgcca
    21541 gatctggggc ggcaccaccg ccctgcccgg actgcgcgaa gccctcggcc tcgacgagtc
    21601 cgccgccacc cgcaccagcg ccgacgaggc cgaggaacag gcccgcgccc tcgtccagtt
    21661 gatggacgac gccgactggg acctcgccgc gatccccgcc gaccagcccc aacaggtccg
    21721 cgccatcctg gagttcgccg cccgcgaggt cgtgccgcgc ctcgccgcca ccaccgccga
    21781 actcgaccac accgtgcacg ccctgaacgg cggcttcgtc ccggcgggcc cctcgggctc
    21841 accgctccga ggcctggtca acgtcctgcc gaccggccgc aacttctact ccgtcgaccc
    21901 caaggccgtc ccctcccggc tcgcctggga gaccggacag gccctcgccg aatcgctggc
    21961 caaccgctac cgcaccgaca acggcgactg gccgacctcg gtcgggctct ccctgtgggg
    22021 cacgagcgcg atgcgcacgg ccggcgacga cgtggccgag gccatggcgc tgctcggcgt
    22081 ccggcccgtc tgggacgacg cctcccgccg ggtcaccggc ctggagccga tcccgctcga
    22141 cgaactcggc cgcccccgca tcgacgtcac cctgcgcatc tcgggcttct tccgcgacgc
    22201 cttcccgcac accatcggcc tgctcgacga cgccgtacgc ctcgcggcct ccctggagga
    22261 gcccgccgag gacaactacg tacgcgccca cacccaggcc gacctcgccg agcacggcga
    22321 cgaacgccgg gccaccaccc gcatcttcgg ctcccgcccc ggcacctacg gcgcgggcct
    22381 gctccagctc atcgactccc gcgactggcg caccgacgcc gacctcgccg aggtctacac
    22441 ggtctggggc ggctatgcct acggccgcga gctcgacggc cgcccggccc gggacgagat
    22501 ggagacggcg tacaagcgga tcgcggtcgc ggcgaagaac accgacaccc gcgagcacga
    22561 catcgccgac tcggacgact acttccagta ccacggcggc atggtggcca ccgtccgcgc
    22621 cctgcgcggc accgcccccg aggcctacat cggcgactcg acgcgccccg agacggtcaa
    22681 gacccgcacc ctggtcgagg agaccagccg ggtcttccgg gcccgggtcg tcaaccccaa
    22741 gtggatcgag gcgatgcgcc gccacggcta caagggcgcc ttcgaactcg ccgccaccgt
    22801 ggactacttg ttcggctacg acgccacgac cggcgtggtc gccgactgga tgtacgacaa
    22861 gttgaccgag acgtacgtcc tggacccggc caaccgcgag ttcctccaga acgccaaccc
    22921 ctgggccctg cacggcatcg cggaacgcct cctggaggcc gagtcccgcg gcatgtgggc
    22981 caagcccgac ccggccgtgc tcgaagcgct gcggcaggtg tacctggaga ccgagggcga
    23041 cctggaggac caggactgaa cgggtaggaa cggcgtacgg acgcacaggg gcgggcccgg
    23101 tcgcgaagac cgggcccgcc cccgtacgtc ggcggcatca gctccgggtg ccgaagtcct
    23161 gggtccacca ggggccgccg gacccgtagt gcacaccgat gccgatctcc ttgtacccgc
    23221 agttcaggat gttggcgcgg tggccggggc tgtgcatcca ggagtccatg acggcggccg
    23281 cgtccgcctg gccccgggcg atgttctcgc cgtacgaact ccactggtac ccggctgcgg
    23341 tgatgcgctc gccggggccc gcgccgctgg ggtcggtgtg gtcgaagaag ttctgcgcgg
    23401 ccatgttctc ggagtgcttg agggcggcgt cgtagagctt cggattgctg gtgagcgccg
    23461 agcaacccgc cttgccgcgc tcggagttga cgagatcgag cacctgctgc acggcggccg
    23521 gggtgccgtc gtccgggccg gccggcgccc gcttggtgct gggcgcgggc ctgggcggtg
    23581 cggcgtgcgt gggcgacttg ctggccggag gcggggagga gtgcttgacc ggggcgctcg
    23641 gcgacggcga actggacgcc ttggaaggcg agttggaggc ggacgggctc ggcgacaggg
    23701 gcccggtgct gatgccgtcg gcgctggcgg cgtcggtggt ggtgaggggg gcgtccgcga
    23761 cggtccggga cgagtcctgg ccggggtcgg tgacgaagcg gtaggcgccg ccgagagccg
    23821 cgacggcggc gagcccggcg atgacggcgg ccgcccggcg ccgtcgccgc gctcgccggt
    23881 cgcgccggtc gcgccgggag gcgggggccc gccgccggcc cgcggcgtgg gcgccgtgcg
    23941 cggcgcgggg agagggctgg gtggcggcgg tcgcgtgggc ggtggtctcc agggcggggg
    24001 cccggccgcc cagaaccgcg agcagaccgg cggtggccgc tcccaccggg accagggcga
    24061 gtccgacgag aagcccctcg gcgggtatga gcccgctcca gtgcccggag cagaccgcgc
    24121 aggtacgggc gtggcgggct atgcgcttgc gccacagggc cgacggcacg ccgtcccagg
    24181 acagggcgag cccgtacagc tcgccacagc gctcgatccc ggccagtgcc cgcacgacga
    24241 cccgggcggt ctccagctgg cccttcatgc gctggacgcg tacggcggcg tgctcggcgc
    24301 tcaggtcgag cgccgaggcg acctcgcccc ggctgagcac gcccgccgcc tccagccacc
    24361 acagcgagag cagcgcccgg tcgtcgggct ccagccagcg ggtggcctcg gtgacctcct
    24421 tgcgctgccc ggacaggccg agccgcacga tggtgagatc gacgaagtcg gcaccggggt
    24481 cggccaggtc gtgggcgtcc tggagtccgc cgtcgacggg ggtacggcgg tggccctgcc
    24541 agtaccggcg gatctcgttc atggtgacgg cgacgagcca cgaccggaag gccgcgggct
    24601 cgcgcagcga gccgagcccg tcgagcatcc gcagcaggct ctcctgcacg acgtcgtcga
    24661 cgtcggcgtg cccgcccagc gcccgcccga cgatgttgta cacgagcggc agatacccgg
    24721 cgacgagctc gtcgcgcgcc cgctgatccc cgtcccgggc cgcgacgacc accgcggcta
    24781 tctgttcact gatcacgcct cgttcactct cccggagcac cgaacctaac tgacccgacg
    24841 gagaggagaa cagggcgacg gccggcggat aacagaaaac ggatgacaga tatcgaccgc
    24901 gcccacccgc ataccgggcg ccacctggcg gtccgggtgg tgcgacgggt gtacgtgagc
    24961 cgtgtcactc ccgcgcgggc gtacgctccg acgcatgagt gacatccccg cgtccgaggc
    25021 ggaacggccg cccgagccgg aacggccgca tgaggccgcg ccggttccgg cagccgtccc
    25081 cggggccgtt cgggggacgg tgccgaagcc gacgccgatg ccgcccccga cgccggacat
    25141 cacgtacacg cagtgcaagc ggtgcggtac ggagctggcc gggctcgacg ggcggtactc
    25201 gtgcggggtc tgcggctggt ccaaccactg gtcggagggt caccgcccgc tcccccgcgc
    25261 cgaggacgac ccggacgcac cgcccacgcc ggtcaatccg ctgggcgagc agtagcggag
    25321 cagtgccggt tcaggccgcc gtgtcggggg ccggggccgg ggtgggggtg aggtcggggg
    25381 tgtgggcagg cgggagcagg gagtcgagaa ggtcccggcc ctcctcccaa ctgcccagca
    25441 ggctcccgga gttgatgtgc ccgatgggtc cggccagatg gtgatgggcg ccccactgtg
    25501 cggcgaaggc ggcggaggtc tcgggggcgc agtacgggtc gttcgtgccg gccaccacca
    25561 gggcggggac gggcagcggg cgcgccgaca gctgggtgaa ggtcggtgcg gacccgctcg
    25621 ggaacgccgg ggacagcggg tcgggcgggg ccaccaggaa cgcggccgtg gcggcgggcg
    25681 aggggttccg gcccagccag gtggccgccg cccagcagcc caggctgtgg gccacgagca
    25741 cgacgtgatc gtgcttccgg gaggcctcgt cgacggccga cccgaccgcc gcgacccagt
    25801 cctccaggtc cggctcggac cacgagtcgg gcgccgtgcg caccgccgac ggcccccagt
    25861 gccgttccca ttcgctctgc cagtggtgct cgtcggaccc gtcgataccg ggaatgatca
    25921 cgtagccgaa catggcttcc ccccgcgctg atcgctcgct gatcgcctgt cgatcgcgtg
    25981 ctggtcgctg tgctgcccgt tgctcttcgt ctgccgctta cggagatccc cgtacccggg
    26041 ccaccgcagg tgtatcgtac cgagcacttc tctcacgaaa tgtactgttt tgtacgatga
    26101 cttgagtgac ccggagttcc ggcgccgcgc gcttctcgcc acgcttccca tggccttcgc
    26161 ggcgagcggg tgcgaggccg cggcgcctcg gcgcgagcgg gaccggcggc ccgtccaggg
    26221 gccaccgccc ggccccgtcc ggcagcccgg ggtggccgag ccccagcagc cgcacatgct
    26281 cttcgtctcc tacgacctca ctcccggcac ccggggcgcc cccgggcggg acgcggtgcg
    26341 gcggctgctc gcgcggtgga gcgagctgct cgccgggctg gcgcccgggc ccaccgcgac
    26401 cgtcggcatc ggccccggcc tgccggagcg gctcggggtc ggggcgcccg agggcctgcg
    26461 tgagctgccc gccttcgtcg gggaacacct ggacgtggcg gcggggggcg gtgagatcgg
    26521 cgtgcagatc tgcgcgcggg acgcgcgggg gtgcgagcgc ctggccgggc tgctcgcggg
    26581 agccggagcg ggggtgctgc ggccgcgctg gcgccaggcg ggcttcctgt cgggcgagcg
    26641 ccccggcccg cgttccgaac tcctcgcgcc cccgcgggcg ggggaggcct cgcgtgacct
    26701 gctgggcttc aagaacggca cgtcgaaccc cacggcggcg gagaacgagc gctgggtgtg
    26761 gctgccgccc ggggggcgtt acgcggacgg cacgttcctg gtggtgcggc ggatccggtt
    26821 gcgggtggag gagttcgggc ggttgccggt cgcccggcag gagcagatcg tcgggtgccg
    26881 caagggcggc ggggaggtgc tgtcctccga cctgaacgcg cgtacgccgg aggggagtta
    26941 cgtcctgccc ctggacgccc acgtgcgcct ggccggaccc gggccggacg gcggcgcccg
    27001 gatgctccgg cggagctact cctacgagaa cagccccggg gaccggggca tgctcttcct
    27061 cgcctacatg cgggaccccg cgctgttcgt acgggtgggc acccggctgg ccgcgtccga
    27121 cgcactcaac tcctttgcgg agcagtacgg ttcggctctg ttctatgtgc tgccgggggt
    27181 aggggggagc ggccgagcac tgggcagcac ggtcctgtag ccctggtccc gcccccttgg
    27241 tgcggcttcg caccgtgctc gcttctcgcg cagttccccg cgcccctaaa agcttcggtg
    27301 ctggccggca tcgggcattt cagcccgtca tgggggtccc ccctggccct taaggccttg
    27361 ggggagtttg aggacgagcg ccgttgaggc gcgaacgggg tccggggcgg agccccgaac
    27421 gggggtgcag ggggcggagc cccttgcggg ggttcgaggg gcgcagcccc tcagcgggtc
    27481 tggggcgaag ccccagggct cagctcatcc aacccgccgc acgggtggga gggtgggcaa
    27541 gcccccgggg tccggggcgg agccccgatc gggggtgcag ggggcggagc cccttgcggg
    27601 ggttcgaggg gcgcagcccc tcagcgggtc tggggcgcag ccctagggct cagctcatcc
    27661 aacccgccgc acgggcgggc gggtgggcaa acccccccgg ggtctggggc gcagccccag
    27721 ggagccggaa ccatccaacc ccgagcgatg ggcaggaggg tgggcaagcc ccccggccaa
    27781 ctccttggca cacgcggtgc catgtgaaat attaccgggg tggtcatgac aagcaccccg
    27841 gacgtcatcg tcgtgggcgc cggcatcgtg ggcgccgcct gcgcctacta cgcggcccgc
    27901 gccggcctga gggtgaccgt cctcgaccgg ggccccgtgg ccggcggcac caccggctcg
    27961 ggcgagggca acctcctcgt ctccgacaag gcccccggcc ccgaactgga actcgccctg
    28021 aaatcggcag agttgtggcg agagctggcc gaacgcctcc cgcccgggat cgagtacgaa
    28081 cccaagggcg gactggtcgt cgcctccgac gaggcggccc tgaccgcgct gcgcaccttc
    28141 gcggcggcgc aggagaaggc gggcgtgacc gtacgcgacg tggcggccga ccggctgccc
    28201 gacctggagc cgcacctggc tcgcggtctc gcggggggcg tccactatcc ccaggacgcc
    28261 caggtcatgc ccgccctcgc cgccacgcat ctgctgcgcg cgtccggcgc cgaggtccgg
    28321 ctcgggcagg aggtgacggg gctgctcacg ggtccgggtg gtgcgatacg cggcgtacgg
    28381 accgcatccg acgtgttcca cgcgccgtac gtcgtcaacg ccgccggtac ttggggcggc
    28441 gaactcgccc ggctggccgg ggtgttgctg ccggtgctgc cccgccgggg cttcgtactg
    28501 gtcacggagc cgctgccgcg cgtggtgcgg cacaaggtgt acgcggcgga ctacgtcgcg
    28561 gacgtggcca gcgactcggc cacgctccag acctcggcgg tggtcgaggg gactccggcg
    28621 gggccggtcc tgatcggcgc gagccgcgag cgggtcgggt tcgaccgtgc cctctcggta
    28681 ccggccctgc ggcggctcgc ggccggggcg accgcgctgt tccccgtgct tgcgggggtg
    28741 cgcgtgatcc ggacgtacgc ggggttccgt ccgtatctgc cggaccacct cccggcgatc
    28801 gggacggatg cgcgggtgcc ggggctcctg cacgcgtgcg gccacgaggg ggcggggatc
    28861 gggctcgccc cggtgacggg gcggatcatc gcggactgcc tgaccggagc ccaaccgccg
    28921 ctggacatcg ccccgttcga tccggctcga ttcgagggcg ggaccggggc gggggccggg
    28981 gcatgaggcg ccggtggcgg tcggcaaagc aggacgtggt ggcccgaacc cctggtgagc
    29041 tggccggggc ccggccgggc cccgcgttcg agatcacggt ggacggccgg gcggtgtcgg
    29101 cgctgccggg gcagaccgtc gcggccgcgt tgtgggccgc gggcgttctg acgtggcgaa
    29161 cgacccgtgg aggtggaagc cctcgggggg tgttctgcgg gatcgggcag tgcttcgact
    29221 gcctggtcac ggtcaacggc gtggccaatc ggagggcgtg ccttgtggcg gtgggccccg
    29281 gggacgaggt caggacgcag gagggggagg ggcgtgggga gctcgcggtg tgagcggggt
    29341 gccggtgcgg gtgcggctcc gccgcgcccc ggtgcgggac gtgcctggcc ggtcgcgcag
    29401 ttccccgcgc ccctgcggga gttgccgtcg ggcgaggtgg ccgcgaagtt ctgggcgtcc
    29461 ccaactgagc tgatgcgagg cggagttgta gtgatggggg agttttccgt gagctcggcg
    29521 gtgttggtgt ggtgaccggg gtgttcgacc ttgtggtggt gggcgcgggg cccgccgggc
    29581 tggccggggc cgggacggcg ggggagctcg ggcttcgggt cgcgctgctg gacatggcgg
    29641 aacacgtcgg gggacagttc taccggcagc ccgccgccgg gctcggggcc gctcggcccg
    29701 aggcgctgca tcacgactgg gacgcgttcg tcgcgctgcg gaagcggctc gcggccgggc
    29761 gggtcgagca cctcgggcgg caccatgtgt gggccgtcga gcggggcggg gacggtgatt
    29821 gggctgtgca cgccgtcgtc ggggacgacg ggggtgaggg gcggcccgtg cgggttcggg
    29881 cgcgggccgt gttgctcgcc accggcgcct atgaacgcca actccctttc gctggctgga
    29941 cgttgcccgg cgtcgtcggg gccggtggtg cgcaggccat gctcaagggc gggctcgtgc
    30001 tgccgggcaa gcgggtcgtc gtcgccggga gcgggccgct gctcctcgcc gtcgcgtcct
    30061 cgctcgcctc ggccggggcc gaggttccgg ccgtgatcga ggcgtccggc tatctcggct
    30121 atgcccgcca cccccgggcg ctcgccgtca acccccgcaa gctcgccgag ggcctgacgc
    30181 acggcgcggc cctgctgcgg caccggatcg cgctgcgtac ccgcagcgcg gtgaccgagg
    30241 cgcacggctc cgagcgggtc gaggcggtca ccgtctcccg gctcgacgcg cggtggcggc
    30301 ccgtgcccgg gtccgggcgg cggatcgcct gtgacgcgct cgccgtcggc cacgggctcg
    30361 tccccgggat cgaactcggc accaccctcg gctgcggcac ccgcaccacc gccgacaaca
    30421 ccctggccct gcacctgggt tcggggcagg agacctccgt gcggggcgtc tggggggccg
    30481 gggaggtcgg tggtgtcgcg ggcgcccaac tcgcccgtat cgagggagag ttggctgccc
    30541 gttccatcgc cgcgcggctc ggtcgtgacc ccggacccga ggggcgcgtg cgacagttgt
    30601 cgtcccgccg cacccggctg cgtaccttcg ccgaagccat ggccgccacg cacgcgccgg
    30661 ggccgggctg gaccggctgg ctctccgacg acaccgaggt gtgccgctgc gaggaggtca
    30721 cggcgggccg cgtccgcgag gcggtcgccg accagggtgc ccgggacgcc cgtaccgtca
    30781 agctgttcac gcgggccggc atgggctggt gccagggacg gatgtgcggg gcggcggtgt
    30841 cctgcctcgc cggggacggc caaccgcccg cacagcggcg cccgttggcg gtgcccctca
    30901 cgctcggggc gctggccggc caggggcccg aggacgcctc ggaaccgagc cagtcgcaaa
    30961 cgtaacgtga cattgtactc tgggtctccg ctcggtacgg aggaacagca gcatgggaca
    31021 cctgaagcag agcaaggtca tcaccaccac cgagcggctg cgcgaccagg tcgcccacgc
    31081 gttgcgcgcc gcgctgatct ccggcgagct gcgccccgga caggtctatt cggcgcccgg
    31141 cctcgccgag gagttcggga tctccgcgac ccccgtgcgc gaggccatgc tcgacctcgc
    31201 ccgggagggc ctggtggagc cggtccgcaa caagggcttc cggatcaccg aggtcaacga
    31261 gcgcgacctc gaccagtaca ccgagatccg tgcgctgatc gaggtcccga tgatcggccg
    31321 gatcacccgc agcgcggacc gcgcggacct ggaggcgctg cggccggtcg ccgaggagat
    31381 cgtgcgcgcg gcccgcgacc acgacctcat cggctatctg gaggccgacc gccgcttcca
    31441 cctctcgctg ctcgccctgt ccgggaacga gcgcctggtg gagaccgtcg gcgatctgcg
    31501 caagcgctcc cgcctgtacg gtctgaccgc gctcgatcag cgcgacgagc tgatcccgtc
    31561 ggccgaggag cacatcgagc tgctcgacct catgctggcc ggtgacgccc gggcggccga
    31621 gaagtgcatg acccgccacc tcggccacgt ccgctcgctg tgggcgagga gcgaggccgc
    31681 cgaaccgaag cccaagcgcc gcctgggcgc ggcccgctga accccgccgg ccccccgccg
    31741 ttcacgcgtg cgccggcccg gtccgcgcga tcgggcaggg gcggcggctc gaccggcccg
    31801 ggggtgccgg ggacgggggc ggctgtcagc gggagccggg gtccttgtcg gccgccgcac
    31861 ggtactccgc gttgaggcgc tgggcctcct ccagctggtc ctccaggatg acgatgcggc
    31921 aggccgcttc gacgggggtg ccctggtcga cgagctcgcg ggcgcgggcg gcgatgcgca
    31981 gctggtagcg ggagtagcgc cggtggccgc cttcggagcg cagcggagtg atcaggcggg
    32041 cctcgccgag ggcgcgcagg aagccggggc tcgcaccgat catctcggcg gcccggccca
    32101 tcgtgtaggc gggatagtcg tcgtcgtcca gtcgaccagt gagcgggctg tccgctgtca
    32161 tgtcacctct ttcgcaccgc gtcgggggtt cgcggtgcct tgcgggaccg cgggcccgag
    32221 gggaaattca acaccatcgg gtgccccggg tgccgcgccg accggctggg gcggcgaaca
    32281 cgggcacacg acgagggccc cgccggtgtc ccggcggggc cctcgtggtg atcgcgtgcg
    32341 gtggtgtgcc cggttccggg tcaggccagc gcgctcacgc cgagcatctc ggacgccgct
    32401 tccagcgggg tcagggtgcg ggcgggcgcg gcctggggca ggccctggca ggtgaagccc
    32461 aggcgggtca tggcccgggt cacctcctgg gcgctgaagt cgcggcggtc ctgccgggtg
    32521 atgacctcgc ccacctgctt gacggggtag tgacggcgtc cgatgaggac ggagtcgccc
    32581 tcgacgggct cgggcttgat gcccttcatg gcggccacca cttgggcctt ggagagatcg
    32641 aacgggaagc gggcgatgac gcagcgcatg atgccttcca aggcttgggg ggtggaccga
    32701 ccgggtgccc ggtcggcggc cggggcgcga acgccccggt gcgatgccgg gtgcgggctc
    32761 aggcggccgt tccggactgg cggggctcgg cggcgcgggc ggggcgggcg gcgcgccggt
    32821 cctgggacgg gcggctgcgg cggccgcgcg aggaggaggc ggaggcgctc cggcgggggc
    32881 gctccactac cggtgccttg atggtgaccg ggatgccgga gggtgcctgg gcgccggtga
    32941 tgcggctcaa ctcctcgtcg cccgagcgca cttgggtggt ctgcggcacg atgctcgcgt
    33001 tgaccatcag gcggctcatc tcgcggcgct ggttgggcgt gacgagggtg acgacgctgc
    33061 cggactcgcc cgcgcgggcg gtgcggccgc cgcggtggag gtagtccttg tggtcggtcg
    33121 gcgggtcgac gttgaccacc aggtcgaggt tgtcgacgtg gatgccgcgc gccgcgacgt
    33181 tggtggcgac caggacggac acgtcaccgg tcttgaactg ggcgagcgta cgggtgcgct
    33241 ggggctgcga cttcccgccg tgcagcgccg ccgcccgcac accgctctgc agcaggtgct
    33301 tggtcagctg atccaccgcg tgcttggtgt ccaggaacat gatcacccgg ccgtcacggg
    33361 ccgcgatctc ggtcgtcgtg gcgtacttgt cggcgctctg cacgtgcagc acgtggtgct
    33421 ccatcgtggt caccgcgccc gccgacgggt ccaccgagtg cacgaccggg tcgctcaggt
    33481 agcggcgcac caggaggtcg acgttgcggt ccagggtcgc cgagaacagc atccgctgcc
    33541 cgcccgggcg cacctggtcc aggagctcgg tgacctgcgg catgaagccc atgtcggcca
    33601 tctggtccgc ctcgtccagg accgtgatgt cgacctggtc cagacggcag tcccggcgct
    33661 cgatcaggtc cttgagccgg cccggcgtcg ccaccacgac ctccgcaccc gaccgcagcg
    33721 cacccgcctg ccgcccgatc gacatcccgc cgacgaccgt cgccagccgc agccgcagag
    33781 cacgggcgta cggggtcagc gcgtcggtga cctgctgggc cagctcacgc gtggggacga
    33841 ggaccagggc gagcggctgg cggggctcgg cgcggcggcc cgccgtgcgg gtgagcatcg
    33901 cgaggccgaa ggcgagggtc ttgccggagc cggtgcggcc acggccgagc acgtcacggc
    33961 cggcgagcga gttcggcagc gtcgcgccct ggatggggaa cgggacgctg aggccctgct
    34021 gggcgagctc ggccaacagc tgcgggggaa gcgcgagttc ggcgaaggcc tcgacggcgg
    34081 gcagcgccgg ggtgatggtg accggcagcg cgaactcgcc ctgggggccg gaggagcggc
    34141 ggccgtaacc gcccgagcgg cccgaggagc cggagcggcc ggacgagccg aaccggccgg
    34201 agccgccgga agagccggag gagccgaagc ggctgccgcc gcggggggcg ccggagccgc
    34261 cggagttatt ggtgcggctg tagcgatcgt tcgtacgggt gcggttcatg cggaaccttc
    34321 cttgatacgg cacgcatcga ggaattcccg ggagaaagca cagtacgggg aatcgcaaga
    34381 acgagccggg cggatgcgaa agcgcatcgg gccgaattcg atattcgggg cgcatcgctg
    34441 tgatgaggtg cgaagaaaat cccgggcgcc gtgggcgggc ggtccctgcc gtgcggcggg
    34501 gcgcgcggtc gatccggggt ggtgcggtgc tgctcggggt gctgcgtggg gtgcgttctc
    34561 gccggtcagg tgctcacggc gggacgggcg cgaagccgtc gtggcgggcg cgggggccgg
    34621 cggcacgggc ggtcgggccc gaaaacgcga cgagccgggg cccgcacccc aaggtgcggg
    34681 ccccagctgc gaagtgcgtg tcgacgatca ggccggaacg atgttctcgg cggtcgggcc
    34741 cttctggccc tgcgcgatgt cgaagttgac cttctggcct tcctggagct cacggaagcc
    34801 ctgggcggcg atgttcgagt agtgggcgaa cacgtccgga ccgccaccgt cctgctcgat
    34861 gaagccgaag cccttttccg cgttgaacca cttcacggta cctgcagcca tgtcattctc
    34921 cttggggcaa tttcggagac cacgccgtgc ggactccgcg tcactgtgat gattgccctg
    34981 ctgggaacca caactgcaac tgatatcgac agtagcacgg cgcaatcgcc gaagcatggt
    35041 caataattct gctcggccgg tcgcgcgaga aattctggtg aggccgcgac aattaattct
    35101 tgtgcggccg tgacagatat acgcgcaccg cggcgagggc cggacggcgt tttccggtgc
    35161 ggcacaacgg cccccggccg tcaggcgggt tgggccgaga ggggtcccgc gggccgtgcg
    35221 ctgactactc tgcacgggtg accaccgagt tgaccttgct tacgcgcgtc gcctaccgcg
    35281 gccaggaggt gaccgcgccc cggctgcgcg ggctcctcgc gctgctcgcc gaagacctgc
    35341 gggccggatg cagcaccggg cggctcgtcg aggggctgtg ggacgacgag ctgcccgaac
    35401 ggcccggcaa ggcggtgcag gtactggtgt cgcggctgcg ctcgcagctc ggccccgacg
    35461 tcgtcgccag caccccggcc ggctaccgcc tcgcgctcac cgaggagcag gtcgacagct
    35521 cggccctgcc gctgcgcgcg gcggccgccg aggcgcgggc ccgcgccggt gcgcacgacg
    35581 atgcgctcgc cgaggcggag gcggggctcg ccctgtggga cggcgtcgtc gcgagcgggg
    35641 acggcgagga cctgcacgac cccgtggccg cgctgcgccg cgcgcgcggc ggcgcccacc
    35701 gcaccctcgt gcgctgccgc gcactcgcgc tcgcccggct cggccgcaag gcggacgcgg
    35761 tccggccgct ggcccagctc gcccgtgaac tgccgcgcga cgaggaggtg ttggcggagc
    35821 tgctgcgctg cgaggccgcc accgcggggc cggccgccgc cctgacccgg tacgacctct
    35881 accgccgcgc cctgcgcgac gagctcggtg ccgaccccgg gcccgaactg gccgctctgc
    35941 accaggagtt gctgcgcggc gaggc
//
