LOCUS       NZ_BMUU01000014        20696 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence14, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000014
VERSION     NZ_BMUU01000014.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 240118)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 140886
            Orig. end                         :: 161582
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20696
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="1"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20696
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20696
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10696](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10696)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    310..323
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.14"
                     /tool="antismash"
     misc_feature    complement(311..324)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    complement(479..492)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            1962..3191
                     /db_xref="GeneID:96294297"
                     /locus_tag="IE233_RS31435"
                     /old_locus_tag="GCM10010326_64000"
     CDS             1962..3191
                     /codon_start=1
                     /db_xref="GeneID:96294297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236057.1"
                     /locus_tag="IE233_RS31435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64000"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_190028910.1"
                     /transl_table=11
                     /translation="MRDVLKRAGAGTAAALAWAGLTAVLVTALTGCSGGALDIGDIGDK
                     PLTPQEAILVTPDDGAKGVKADQKVEVRVPGGRLERVKVMKTEDAQPEEVPGKISEDGL
                     TWTPTGGALQLAALYTVDTVALDGHGRRQARHTSFATLVPEHRFIGYFKPENRSTVGVG
                     MIVSFNFNQGIKDKAAVERAIRITSQPPVEVRGHWFGKDRLDFRPEKYWVPGTKVTVDM
                     RLRDVLAAPDVYGIQDKTIGFTVGRDQESLVDAEAHTMEVRRGGELVSTLPISAGSPKN
                     TTYNGKMIVTEMYDVTRMNSQTVGFGGEYDIPDVPHAIRLTNTGTFLHGNYWAPSSTFG
                     NSNTSHGCVGLRDVKGGSSDTPAGWFFDRTLIGDVVEVVNSHDREVAPDNGLSGWNLDW
                     AKWKAGSAIS"
     misc_feature    complement(3340..3355)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(3351..3361)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            3477..4712
                     /db_xref="GeneID:96294298"
                     /locus_tag="IE233_RS31440"
                     /old_locus_tag="GCM10010326_64010"
     CDS             3477..4712
                     /codon_start=1
                     /db_xref="GeneID:96294298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578797.1"
                     /locus_tag="IE233_RS31440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64010"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_161248691.1"
                     /transl_table=11
                     /translation="MNGQPISGAAAGRSGRRGSAVLALICGALLLLVTACGGGDGGSKS
                     KAGSAGATEDTKASEAVVDVVPADNAKDVATSGALKISADKGRLTAVAVADSKGNAVAG
                     KISADGLGWVPDQHLASATQYKVHAVAKDAKGRESAKDTTFTTLVPKNTFIGQYVPEDG
                     STVGVGMPVSINFSRGITNPDAVEKAITVTAEPSVPVEGHWFGNDRLDFRPENYWAPGT
                     KVTVKLNLDGVEGRPGVYGKQTRTVHFTIGRSQVSTVDASAHTMKVERDGKLLKTIPIS
                     AGSPQNTTYNGQMVISEKFEVTRMNGATVGFGGEYDIKDVPHAMRLSSSGTFIHGNYWG
                     DPSVFGSANTSHGCVGLRDARGAGDPSTPAAWFYNSSLIGDVVVVKNSKDKVIQADNGL
                     NGWNLSWSEWTK"
     gene            4794..5561
                     /db_xref="GeneID:96294299"
                     /locus_tag="IE233_RS31445"
                     /old_locus_tag="GCM10010326_64020"
     CDS             4794..5561
                     /NRPS_PKS="Domain: ECH (4-246). E-value: 1.6e-76. Score:
                     248.8. Matches aSDomain:
                     nrpspksdomains_IE233_RS31445_ECH.1"
                     /codon_start=1
                     /db_xref="GeneID:96294299"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432556.1"
                     /locus_tag="IE233_RS31445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64020"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_161248689.1"
                     /transl_table=11
                     /translation="MTVNLEVSEGVGTIRLNRPPMNALDVATQDRLRELAEEAARRDDV
                     RAVVLYGGEKLFAAGADIKEMQAMDHAAMVVRGRALQESFTAVARIPKPVVAAVTGYAL
                     GGGCELALCADFRIAGDNAKLGQPEILLGLIPGAGGTQRLARLVGPSKAKDLIFTGRQV
                     KADEALAMGLVDQVVPAAEVYERAHAWAARLAQGPAIALRAAKESIDTGLEADIDTGLA
                     VERNWFAGLFATEDRERGMRSFVEEGPGKAKFL"
     aSDomain        4806..5531
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS31445_ECH.1"
                     /evalue="1.60E-76"
                     /label="IE233_RS31445_ECH.1"
                     /locus_tag="IE233_RS31445"
                     /protein_end="246"
                     /protein_start="4"
                     /score="248.8"
                     /tool="antismash"
                     /translation="LEVSEGVGTIRLNRPPMNALDVATQDRLRELAEEAARRDDVRAVV
                     LYGGEKLFAAGADIKEMQAMDHAAMVVRGRALQESFTAVARIPKPVVAAVTGYALGGGC
                     ELALCADFRIAGDNAKLGQPEILLGLIPGAGGTQRLARLVGPSKAKDLIFTGRQVKADE
                     ALAMGLVDQVVPAAEVYERAHAWAARLAQGPAIALRAAKESIDTGLEADIDTGLAVERN
                     WFAGLFATEDRERGMRSFVE"
     gene            5848..6351
                     /db_xref="GeneID:96294300"
                     /locus_tag="IE233_RS31450"
                     /old_locus_tag="GCM10010326_64030"
     CDS             5848..6351
                     /codon_start=1
                     /db_xref="GeneID:96294300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048437.1"
                     /locus_tag="IE233_RS31450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64030"
                     /product="ATP-binding protein"
                     /protein_id="WP_161248687.1"
                     /transl_table=11
                     /translation="MAGLEGVEQPAQRVSATAARWMPSADDELALKALELFGNPTEEEV
                     RLPSRPESAATARRITQSVVLRQWALSPTLAEHAVLLVSELVGNAVRHTGARVFGLRML
                     RRRGWIRIEVRDPSRGLPCLMPVHELDVSGRGLFLVDKLSDRWGVDLLPRGKTTWFEMR
                     VADR"
     gene            6756..7568
                     /db_xref="GeneID:96294301"
                     /locus_tag="IE233_RS31455"
                     /old_locus_tag="GCM10010326_64040"
     CDS             6756..7568
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294301"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521232.1"
                     /locus_tag="IE233_RS31455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64040"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_190028955.1"
                     /transl_table=11
                     /translation="MNPSPRAVDRRSALRAGAGAAIVGAFTTGCSDDKGGARPAESPTP
                     PSASAAAAPARPGKSRPAPAPRAFPGQPVQIESGPRARPQVALTFHGQGDPKIATTLLS
                     EAEKAGARVTVLAVGSWLDEQPAMARRILDGGHELGNHTQHHIDISTMDESEAYAEITG
                     CADRLRRLTGSIGTWFRPSRAQYATPLVQKLARQAGYPHVLSYDVDSLDFTSPGASAVT
                     RNVTGQIRNGSVVSLHFGYADTVAALPVLLAELERRRLRAVTTTELLI"
     gene            7568..8749
                     /db_xref="GeneID:96294302"
                     /locus_tag="IE233_RS31460"
                     /old_locus_tag="GCM10010326_64050"
     CDS             7568..8749
                     /codon_start=1
                     /db_xref="GeneID:96294302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432553.1"
                     /locus_tag="IE233_RS31460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64050"
                     /product="YncE family protein"
                     /protein_id="WP_190028911.1"
                     /transl_table=11
                     /translation="MPTATKTTTALLAAVLLAALAGCGSGPDHKDEALSTKAALPPAVV
                     KKPVPQGLPGMPPVLDPKDAYAADRPNALQPAVKNFLPRVYVPNTNSNTVSVIDPATYK
                     VIETIPVGHQPQHVVPSWDMKTLWVNNDLGDSLTAIDPATGKTGRTVQVSDPYNLYFTP
                     NGKYAIVMASMDRELVFRDPVTMNRVKTVPVTCAGVNHADFSMDGRYFIVSCEFSGELL
                     KVDTEKMQIVGQQKLPFDGAMPQDVKMSPDGKTFYVADMMAHGMWVLNGDKFDKPVLLP
                     TGKGCHGLYISRDSKEMYISNRGEGTISIFDFTKDKLTKKWELPDGGSPDMGGVSADGK
                     VLWLSGRYNAEVYAIDTATGKELARIPVGSGPHGLAVYPQPGRYSLGHTGIFR"
     gene            complement(8814..10004)
                     /db_xref="GeneID:96294303"
                     /locus_tag="IE233_RS31465"
                     /old_locus_tag="GCM10010326_64060"
     CDS             complement(8814..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294303"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889608.1"
                     /locus_tag="IE233_RS31465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64060"
                     /product="cytochrome P450"
                     /protein_id="WP_190028912.1"
                     /sec_met_domain="p450 (E-value: 7e-17, bitscore: 54.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPEPVLDFPLSRRGDVLPEECTWLREKQPVARVRTLTGDQAWLV
                     SSHALAKQVLEDERFSLKDTAAPGVPRQYALTIPPEVVNNMGNINSAGLRSAVMKSLSP
                     RADGLVNRLRERAGEFVDALLTEGPPADLRAGFADPFSAALHCQVIGVPFTDWRRLMSG
                     LDTAFMTSAHTFEGAGLNWYKDLGYMVERLNAPDVPPDSLLGRLGALREDRESAHLTDE
                     MLATVAVSMFGAGAVSTSAFLSLAVLALLQHPELIGRLREHPERMGRAVDELLRWNLSI
                     GDGLPRLALEDVRLGEVLVEKGELVLVLVEGANFDPAVFSDPERLDLDREHNPHLSFGA
                     GRHFCPATGLGRLHAETALSVLVDRMPGLRLAVPAEQLVWRTGFIKRLPERLPVLW"
     gene            complement(10001..10696)
                     /db_xref="GeneID:96294304"
                     /locus_tag="IE233_RS31470"
                     /old_locus_tag="GCM10010326_64070"
     CDS             complement(10001..10696)
                     /codon_start=1
                     /db_xref="GeneID:96294304"
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889609.1"
                     /locus_tag="IE233_RS31470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64070"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_190028913.1"
                     /sec_met_domain="CDPS (E-value: 6.3e-86, bitscore: 281.2,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAITTEAFTVQPFTRSCHHIWDEGDHVLIGVSPGNSYFSAGRITE
                     LVRWASARFSRIDIVYADLHVADLFSALGYERDHAARRASKELKAVRRRILRGIEDAGP
                     QGTPVDVHGLSEFAGNPVYELLHRRVRHFLSTDPHFRAGCEHMAAHFLATKAGEPAVSA
                     EQLSACLDYIVAELPFFLDTPGILGVPSSVSCYHAPIPLTELLYAKGGGLRASRNQAYA
                     VVRPEGIAA"
     gene            11058..11270
                     /db_xref="GeneID:96294305"
                     /locus_tag="IE233_RS31475"
                     /old_locus_tag="GCM10010326_64080"
     CDS             11058..11270
                     /codon_start=1
                     /db_xref="GeneID:96294305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641092.1"
                     /locus_tag="IE233_RS31475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64080"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_161251968.1"
                     /transl_table=11
                     /translation="MADIEEARKAFAKLDVDGDGRVTASEYKAVMAQLGDFHVTETVAQ
                     AIIRAKDANGDGKLSFEEFWASLNK"
     gene            11332..12054
                     /db_xref="GeneID:96294306"
                     /locus_tag="IE233_RS31480"
                     /old_locus_tag="GCM10010326_64090"
     CDS             11332..12054
                     /codon_start=1
                     /db_xref="GeneID:96294306"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151202.1"
                     /locus_tag="IE233_RS31480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64090"
                     /product="NADPH-dependent F420 reductase"
                     /protein_id="WP_267907209.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 9.6e-11, bitscore:
                     35.0, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSGRGFSERVNAPTPEGQLMKIGIIGAGNIGGNLTRRLTALGH
                     QVSIANSRGPHTLSALAEETGATPVTVEQAADGAQVVVVTIPLKNVPDLPKDLFGKAAD
                     GLAVIDTGNYYPKERDGRIDAIEDGLPESRWTEQHIGHPVIKVFNGTYAQDLLDRPRPK
                     GAPDRVAVPVAGDDAAAKQLVRELVDELGFDTVDAGGIDDSWRQQPATPVYGLRGNTAE
                     VTEALAAAPKERPAAHSA"
     gene            complement(12074..13444)
                     /db_xref="GeneID:96294307"
                     /locus_tag="IE233_RS31485"
                     /old_locus_tag="GCM10010326_64100"
     CDS             complement(12074..13444)
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889625.1"
                     /locus_tag="IE233_RS31485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64100"
                     /product="L-serine ammonia-lyase"
                     /protein_id="WP_161251963.1"
                     /transl_table=11
                     /translation="MAISVFDLFSIGIGPSSSHTVGPMRAARMFAARLKNEGLIAHTAR
                     IRSELYGSLGATGHGHGTPKAVLLGLEGASPRTVDVENADARVEKIKDSGRLNVLGMHE
                     IGFAYDDDLVLHRRKALPYHANGMTVFAYDVDGALLLEKTYYSVGGGFVVDEDAVAGEN
                     PIVPDDTVLRHPFRTGDELLRLAQDTGLSISALMLENEKAWRTEDEIRSGLLDIWRVMQ
                     ACVSRGMSREGILPGGLKVRRRAANTARLLRAEGNPEAHAMEWATLYAMAVNEENAAGG
                     RVVTAPTNGAAGIIPAVLHYYMNFVPGADEDGIVRFLLAAGAIGMLFKENASISGAEVG
                     CQGEVGSACSMAAGALAEVLGGTPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNG
                     MAAVKAVTAAKMAMRGDGSHKVSLDKVIKTMKETGADMSVKYKETARGGLAVNIIEC"
     gene            complement(13602..14861)
                     /db_xref="GeneID:96294308"
                     /gene="glyA"
                     /locus_tag="IE233_RS31490"
                     /old_locus_tag="GCM10010326_64110"
     CDS             complement(13602..14861)
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (77-368). E-value:
                     5.6e-14. Score: 43.9. Matches aSDomain:
                     nrpspksdomains_IE233_RS31490_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GeneID:96294308"
                     /gene="glyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457161.1"
                     /locus_tag="IE233_RS31490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64110"
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_161251961.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.2e-13, bitscore:
                     43.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLNQPLHELDPDVAAAVDAELHRQQSTLEMIASENFAPVAVME
                     AQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAA
                     AMFALLKPGDTIMGLNLAHGGHLTHGMKINFSGKLYNVVPYHVDETGEVDMAEVERLAK
                     ESKPKLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHV
                     VTTTTHKTLGGPRGGVILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEF
                     KERQQRTLDGARILAERLVQDDVRAVGVDVLTGGTDVHLVLVDLRNSELDGQQAEDRLH
                     EVGITVNRNAIPNDPRPPMVTSGLRIGTPALATRGFGDDDFREVADIIAEALKPDFDQD
                     ALAARVSALAAKHPLYPGLK"
     aSDomain        complement(13758..14630)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS31490_Aminotran_1_2.1"
                     /evalue="5.60E-14"
                     /label="IE233_RS31490_Aminotran_1_2.1"
                     /locus_tag="IE233_RS31490"
                     /protein_end="368"
                     /protein_start="77"
                     /score="43.9"
                     /tool="antismash"
                     /translation="AIDRIKALFGAEAANVQPHSGAQANAAAMFALLKPGDTIMGLNLA
                     HGGHLTHGMKINFSGKLYNVVPYHVDETGEVDMAEVERLAKESKPKLIVAGWSAYPRQL
                     DFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHVVTTTTHKTLGGPRGGVIL
                     STQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEFKERQQRTLDGARILAERL
                     VQDDVRAVGVDVLTGGTDVHLVLVDLRNSELDGQQAEDRLHEVGITVNRNAIPNDPRPP
                     MVTSGLRIGT"
     gene            complement(14900..15274)
                     /db_xref="GeneID:96294309"
                     /gene="gcvH"
                     /locus_tag="IE233_RS31495"
                     /old_locus_tag="GCM10010326_64120"
     CDS             complement(14900..15274)
                     /GO_component="GO:0005960 - glycine cleavage complex
                     [Evidence IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294309"
                     /gene="gcvH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946794.1"
                     /locus_tag="IE233_RS31495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64120"
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="WP_161251959.1"
                     /transl_table=11
                     /translation="MSNPQQLRYSKEHEWLSSAEDGVSTVGITEHAANALGDVVYVQLP
                     EVGDTVTAGETCGELESTKSVSDLYSPVTGEVVAANQDVVDDPSLVNSAPFEGGWLFKV
                     KVTDEPGDLLSADEYTDFAS"
     gene            complement(15375..16499)
                     /db_xref="GeneID:96294310"
                     /gene="gcvT"
                     /locus_tag="IE233_RS31500"
                     /old_locus_tag="GCM10010326_64130"
     CDS             complement(15375..16499)
                     /EC_number="2.1.2.10"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004047 - aminomethyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96294310"
                     /gene="gcvT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018509776.1"
                     /locus_tag="IE233_RS31500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64130"
                     /product="glycine cleavage system aminomethyltransferase
                     GcvT"
                     /protein_id="WP_190028915.1"
                     /transl_table=11
                     /translation="MSNAPRLTSLDALHRSLGATMTDFAGWDMPLRYGSERDEHNAVRT
                     RAGLFDLSHMGEITVTGPEAMKALNYALVGNIATIGLGRARYTMICQEDGGIVDDLIVY
                     RLGETEAPEYLVVANAGNAQIVLDAITERAAGFDAEVRDDRDAYALIAVQGPESPGILK
                     SVTDADLDGLKYYAGLPGTVAGVPALIARTGYTGEDGFELFVAPEHAEQLWRALTDAGQ
                     GAGLVPCGLSCRDTLRLEAGMPLYGHELTTALTPFDAGLGRVVKFEKDGDFVGRKALEA
                     AAEKAEANPPRKLVGLIAEGRRVPRAGFSVVAGGEVVGEVTSGAPSPTLGKPIAIAYVD
                     AAHAAPGTGGVGIDIRGTHEAYEVVALPFYKRQK"
     regulatory      complement(16653..16750)
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            16880..17548
                     /db_xref="GeneID:96294311"
                     /locus_tag="IE233_RS31505"
                     /old_locus_tag="GCM10010326_64140"
     CDS             16880..17548
                     /codon_start=1
                     /db_xref="GeneID:96294311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010041758.1"
                     /locus_tag="IE233_RS31505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64140"
                     /product="AAA family ATPase"
                     /protein_id="WP_161251955.1"
                     /transl_table=11
                     /translation="MTVGHGTGRTREAPEAEGPGRAARDRPPRPVMSEAVRDLRGRPGR
                     TPPELLFDAGDVVVVSGLPGSGKTTLMRRTVTDRRIDSQDTRLAWQRRLPGIPYALYRP
                     LTRTAHFARTWWALRSGDSLVVHDCGTQAWVRHWLGRGARRRGRALRLVVLDVAPGTAL
                     EGQAARGRWVSRYAFARHRGAARRLIAQVEAGRLPTGCASAVLLDRESASVLHRIGFTK
                     "
     gene            17655..18428
                     /db_xref="GeneID:96294312"
                     /locus_tag="IE233_RS31510"
                     /old_locus_tag="GCM10010326_64150"
     CDS             17655..18428
                     /codon_start=1
                     /db_xref="GeneID:96294312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048456.1"
                     /locus_tag="IE233_RS31510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64150"
                     /product="enhanced serine sensitivity protein SseB"
                     /protein_id="WP_161251953.1"
                     /transl_table=11
                     /translation="MNFPEQAFAHPHGGGGWPGNELEEVLSAAVGQPDAGPRLIEVLGR
                     NPVWVPLPNGGSQDSRDLDLPTMELDGAPYVPVYSSEQQFLRCVGSHMSFAVAPAVEFA
                     RGLPPQLGIVVNPEGAVGMPLPPPAVAELCRTGLTALDGPASGARVRLFEPDWQEEPVD
                     FLAVAAEEFEAIGVVLSARRALASIEGESPTLFIGVEFATWDGAGRGAPMEALGRALGR
                     VPVGWPVNLVLLDVTQDPVATWMRERVRPFYARAQ"
     gene            18596..19393
                     /db_xref="GeneID:96294313"
                     /locus_tag="IE233_RS31515"
                     /old_locus_tag="GCM10010326_64160"
     CDS             18596..19393
                     /codon_start=1
                     /db_xref="GeneID:96294313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018531256.1"
                     /locus_tag="IE233_RS31515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_64160"
                     /product="enhanced serine sensitivity protein SseB
                     C-terminal domain-containing protein"
                     /protein_id="WP_161251951.1"
                     /transl_table=11
                     /translation="MSASGTAAAGQVEHMLRQVTPGRYDVYEALLHALADPASGRIWML
                     LWNGRPGSPDAQYGNMEVDGVSYAPCVTSAQELSASGWNREHEVSGALDIARSLYPDRY
                     GIWLNPHAPGGGVGIPWTDLRRIATGLDRMPAGPLRLSEPAVEIPQFYALLAQHAHRTP
                     AVRSLRRAWVQPALGTPYLAIGLDLYDTGPQSVDAVRAMMQQSIPAVPDGLAVSTVAMS
                     DAYDPVGMWLKAATRPFYDREAHAAPAPGGPGYGYPPAAPRTY"
     misc_feature    19502..19516
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.2"
                     /tool="antismash"
     misc_feature    complement(20586..20606)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.9"
                     /tool="antismash"
ORIGIN
        1 gagcagaccg cgcgcgcccg gctgctccag gagcgaccag tcgagccagc tcacctcgcc
       61 gtcctggcag tacgcgttgt tgttgccgcc ctgggtgcgg cccatctcgt cgcccgcgac
      121 cagcatcggc acgcccgtcg acacgagcag ggtggtgagc aggttccgca gctggcgccg
      181 gcgcagcgcg ttgacctccg ggtcgtcggt ctcgccctcc accccgcagt tccaggcgcg
      241 gttgtcgtcg gtgccgtccc ggttgccctc gccgttggcc tcgttgtgct tgcgctcgta
      301 cgacaccagg tcccgcagcg tgaagccgtc gtgcgcggtg atgaagttga tggacgcgta
      361 cgggcgccgg ccgccccagg cgtacaggtc gctggagccc gagaggcggt agccgaggtc
      421 gcgcatgtcc ggcagcgcgc gccgccagaa gtcccgtacc gcgtcccggt agcggtcgtt
      481 ccactcggtc cacagcggcg ggaaggcacc cacctggtag ccgccgttgc ccacgtccca
      541 cggttcggcg atcagcttca cgcggcgcag caccgggtcc tgggcgatca ccgcgaggaa
      601 gggcgacagc atgtcgacgt cgtgcatcga gcgggccagc gccgccgcga ggtcgaaccg
      661 gaagccgtcc acccccatct cggtgaccca gtagcgcagc gaatcggtga tcaggcgcag
      721 cacatggggc tggaccacgt gcagggtgtt gccgcagccg gtgtagtcgg cgtagcgccg
      781 ggcgtccgcc tggaggcggt agtagccgcg gttgtcgatg ccgcgcaggg acagcgtcgg
      841 ccccatctcg ctcgcctcgg cggtgtggtt gtagaccacg tcgaggatca cctcgatgcc
      901 cgcctcgtgc agtgcccgca ccatccgctt gaactcgccg acctgctgtc ccgcggtgcc
      961 gctcgcgcag tagccggcgt gcggcgcgaa gtagccgatc gagttgtagc cccagtagtt
     1021 cttcaggccc cgccgcagca gatggtcctc gtgcgcgaac tggtgcaccg gaagcagctc
     1081 gaccgcggtg accccgagcc gcaccaggtg gtcgatcgcg gccgggtgcg cgagcccggc
     1141 gtaggtgccg cgcagcggtt cggggatgtc cgggtgcagc cgggtgaagc cgcgtacgtg
     1201 cagctcgtag atgacggagt cggaccaggg cgtcttggga cggcggtcgt cggcccagtc
     1261 gtcgtcgtcc tgcaccacca cgcccttggg gacgtgcggc gccgagtcgc ggtcgtcgcg
     1321 cacggtgtcg gcgacctgct gctgcggcca gtcccgtacg tgcccgtaca cctcgggcgg
     1381 cagcacgaag tcgccgtcca cggcgcgcgc gtacgggtcg agcagcagct tcgccgggtt
     1441 ccagcgggct cccgtccacg ggtcccagcg cccgtgcacc cggaatccgt accgctgccc
     1501 ggggcgcacc ccggggacga agccgtgcca gatctcatgg gtcagctcgg tgaggacgag
     1561 ccgggtctcg gtgcccgccg cgtcgaacag gcacagctcc accgattcgg cgcctcccgc
     1621 ccacagcgcg aagttggtgc ccgcgacccc gtccgggccg acccggaagc gggcgcccag
     1681 cggcgtgggg gcgcccggcc agaccggggg gcgcagggct cccggttcac cccggtggcc
     1741 gttcaccgtg cggtgcccct ccgtaccggg ggcgccgccc gcggcactcc gcactgcctt
     1801 ctgttcggct gcgctcgaca cctgacggcc tcccgcggct cggcgcgggg gcggcagcgg
     1861 cgtcccggcc gcggcttccc tgcgcgtctc tgcacctgtt cttcccgcaa cagccctcgt
     1921 actcacgttt cccccggcgg ggggcggtcg ttgggccggt cgtgagagac gtactgaagc
     1981 gggcaggggc gggcacggcc gccgccctgg catgggcagg actgacggcg gtcctggtga
     2041 ccgcgctgac cgggtgctcg ggcggcgccc tggacatcgg cgacatcggc gacaagccgt
     2101 tgacgccgca ggaggccatc ctggtgaccc cggacgacgg ggccaaggga gtcaaggcgg
     2161 accagaaggt ggaggtgcgg gtgccgggcg ggcgcctgga acgggtcaag gtcatgaaga
     2221 cggaggacgc gcagcccgag gaggtgccgg ggaagatctc cgaggacggg ctgacctgga
     2281 cgccgaccgg gggcgcgctg caactggcgg ccctctacac ggtggacacc gtggcgctcg
     2341 acggccacgg ccgccgccag gcccggcaca ccagcttcgc caccctcgtg cccgagcacc
     2401 gcttcatcgg gtacttcaag ccggagaacc gctcgacggt gggcgtcggc atgatcgtct
     2461 cgttcaactt caaccagggg atcaaggaca aggcggccgt cgagcgcgcc atcaggatca
     2521 cctcgcagcc ccccgtggag gtgcgcggcc actggttcgg caaggaccgg ctcgacttcc
     2581 ggcccgagaa gtactgggtg cccggcacca aggtcaccgt cgacatgcgg ctgcgcgatg
     2641 tgctcgcggc ccccgacgtc tacggcatcc aggacaagac gatcggcttc accgtggggc
     2701 gcgaccagga gtccctggtg gacgccgagg cgcacaccat ggaggtgcgg cgcggcggcg
     2761 agctggtgtc gacgctgccg atctccgcgg ggtcgccgaa gaacaccacg tacaacggga
     2821 agatgatcgt caccgagatg tacgacgtga cgcggatgaa cagccagacc gtcgggttcg
     2881 gcggggagta cgacatcccg gacgtgccgc acgccatccg gctcaccaac accggcacct
     2941 tcctgcacgg caactactgg gctccctcca gcaccttcgg caactccaac accagccacg
     3001 gctgtgtcgg actgcgggac gtgaagggcg gcagctcgga caccccggcg ggctggttct
     3061 tcgaccggac cctcatcggc gacgtggtcg aggtcgtcaa ctcccatgac cgcgaggtcg
     3121 ctccggacaa cgggctcagt ggctggaacc tggactgggc gaagtggaag gcgggctccg
     3181 ccatctcctg agagccgccc gcggatctgc cgaggccccg ctgaggcacc ctgaggacct
     3241 tctgggcccc gcaccctcga acgcacggcc ccatgaccgt tcccggttaa ccaaccggga
     3301 acggttcctg tgtttcacct gagagttcca ggaaaacttg ggactgaacg gtgacatggg
     3361 agggggagat cggggccggt tcggtgtgat tatctagcgc cgtgcgcgcg aggacgtgcg
     3421 cgggggtgag tgagtgcggg cggtggcggg gccacgccgt gcgaggggag aaagtcttga
     3481 acgggcagcc tatttcgggg gccgcggccg gacggagcgg tcgtcggggc agcgcagtgc
     3541 tggccctcat atgcggggcg ctgctgctcc tcgtcaccgc gtgcggcgga ggcgacggcg
     3601 gatccaagtc gaaggccggc agcgcgggcg ccaccgagga caccaaggcg tccgaggccg
     3661 tggtcgacgt cgtcccggcg gacaacgcca aggacgtcgc caccagcggc gcgctgaaga
     3721 tatccgccga caagggcagg ctgaccgccg tcgcggtcgc cgacagcaag ggcaacgcgg
     3781 tcgccgggaa gatatccgcg gacggcctcg gctgggtccc ggaccagcac ctcgcctccg
     3841 ccacgcagta caaggtccac gcggtcgcca aggacgccaa gggccgtgag tccgccaagg
     3901 acaccacgtt caccacgctc gtcccgaaga acaccttcat cggccagtac gtgcccgagg
     3961 acggctccac cgtcggcgtc gggatgccgg tctccatcaa cttcagccgg ggcatcacca
     4021 acccggacgc ggtcgagaag gcgatcaccg tgacggccga gccgtccgtc ccggtcgagg
     4081 gccactggtt cggcaacgac cgcctcgact tccgccccga gaactactgg gcgcccggca
     4141 ccaaggtcac cgtcaagctg aacctggacg gtgtcgaggg ccggcccggt gtctacggca
     4201 agcagacccg caccgtccac ttcaccatcg gccgctccca ggtctccacc gtcgacgcga
     4261 gcgcccacac catgaaggtg gagcgcgacg gcaagctcct gaagaccatc ccgatcagcg
     4321 cgggctcccc gcagaacacc acgtacaacg ggcagatggt catcagtgag aagttcgagg
     4381 tgacgcgcat gaacggcgcc accgtcggct tcggcggcga gtacgacatc aaggacgtgc
     4441 cgcacgcgat gcgcctgtcc agctcgggca ccttcatcca cggcaactac tggggcgacc
     4501 cgtcggtgtt cggctcggcc aacaccagcc acggctgcgt cggtctgcgc gacgcacgcg
     4561 gcgcgggcga cccgtcgacg ccggccgcct ggttctacaa cagctccctg atcggcgacg
     4621 tggtcgtcgt gaagaactcc aaggacaagg tcatccaggc cgacaacggt ctcaacggct
     4681 ggaacctctc ctggtcggag tggaccaagt aggcccgaac cgaccccgac ggacccggtg
     4741 ctgtgagcga cagcaccggg tccgttgccg ttagtggccg ttaacctgcc ttcatgactg
     4801 tgaacctgga agtctccgag ggcgtcggca ccattcgcct gaaccgcccc ccgatgaacg
     4861 cgctcgacgt cgcgacgcag gaccggctgc gcgagctggc cgaggaggcg gcccggcgcg
     4921 acgacgtgcg ggcggtggtc ctgtacggcg gcgagaagct gttcgcggcg ggcgcggaca
     4981 tcaaggaaat gcaggcgatg gaccacgcgg cgatggtcgt gcgcggccgg gcgctgcagg
     5041 agtccttcac cgccgtcgcc cggatcccca agcccgtcgt ggcggccgtc accggctacg
     5101 cgctcggcgg cggctgcgag ttggcgctgt gcgccgactt ccgcatcgcc ggcgacaacg
     5161 ccaagctcgg ccagcccgag atcctgctcg gcctgatccc gggcgcgggt ggcacccagc
     5221 gcctggcccg gctggtcggc ccgtccaagg cgaaggacct gatcttcacc ggccgacagg
     5281 tgaaggcgga cgaggcgctc gccatgggcc tcgtcgacca ggtggtgccg gccgccgagg
     5341 tgtacgagcg ggcccacgcc tgggccgcgc gcctcgcgca gggtccggcg atcgcgctgc
     5401 gcgccgccaa ggagtccatc gacacgggtc tggaggcgga catcgacacg ggcctcgccg
     5461 tcgaacgcaa ctggttcgcg ggcctgttcg ccaccgagga ccgcgagcgg ggcatgcgca
     5521 gcttcgtcga ggagggcccg ggcaaggcca agttcctctg agcgcaggca agttgagggc
     5581 actgggtcaa cgacggctgt acatgtgatg gtgatgtgta caccctgtgg ggggattagc
     5641 gcagccttaa gggcacctta aggaaaacct ctccggaacg cttggtgatc aagcgaacgc
     5701 ggcaggtcat cgcaggtcgg atggggtgtg gtcgcctctg gactgcccct gacatatgcc
     5761 aatcagcgcc tccggaacgt caggttccgg aggcgctatt ccttcggaac cgccccggag
     5821 gccgccccgg gccgccatga tggaggcatg gcggggctgg agggtgtgga acaaccggcg
     5881 cagcgcgtga gtgcgaccgc ggcacgctgg atgccgtccg ccgacgacga actggcgctg
     5941 aaggcgctgg agttgttcgg taatccgacg gaggaagaag tgcggctgcc gtcgcggccg
     6001 gagtccgcgg cgacggcccg ccggatcacc cagtccgtgg tgctgcgcca gtgggcgctc
     6061 tcgccgaccc tcgccgaaca tgcggtgctg ctcgtctccg agctcgtcgg caacgcggtc
     6121 cggcacaccg gggcccgggt cttcgggctg cggatgctgc gccgccgggg ctggatccgg
     6181 atcgaggtgc gcgacccctc gcgcggcctg ccctgtctga tgccggtgca cgagctcgac
     6241 gtcagcgggc ggggcctctt cctcgtcgac aagctctccg accgctgggg cgtggatctg
     6301 ctgccgcgcg gcaagaccac ctggttcgag atgcgggtcg ccgaccgctg aggcgccggc
     6361 cgcgacggcc gggaatcaca gaagccccct ggctgccgga tgcggcgcct gcgggggctt
     6421 ctgtggagcg ccgcggaccg aagggggtgt gatccacggc gactgaagac gacctggccc
     6481 gggtcaatgg gggtcgtggc tccgactatg acagatggtc gccccatcct caaaagtcct
     6541 tagtcggaca taacgggatc aactattaca gtttagctgt gaatcgtagg tgagctacag
     6601 cactcacctt ccaaagcatg aataagtatc ggggcccctg agtgaatcag tgccctgggt
     6661 gccctccgag cgtccccggg caacgcgacc cgcaaaggtc ctgaagtggg tcaatcgtta
     6721 ccaaccgacc ctcggcgcac ttaaatgtcc atgtgctgaa tccatcaccc cgtgcggtag
     6781 accgccgcag cgccctgcgg gccggggcgg gcgcggccat cgtgggggca ttcacgacgg
     6841 gctgctcgga cgacaagggc ggcgcgcggc cggccgaatc cccgacgccg ccgtccgcct
     6901 ccgcggccgc cgcccccgcc cgccccggca agtcccgccc cgcaccggcc ccccgcgcct
     6961 ttcccgggca gccggtccag atcgagagcg gaccccgggc ccgcccgcag gtcgccctca
     7021 ccttccacgg ccagggcgat ccgaagatcg ccaccaccct gctcagcgag gccgagaagg
     7081 ccggtgcccg cgtcaccgtc ctcgccgtcg gcagctggct cgacgagcag cccgcgatgg
     7141 cccgccgcat cctggacggc ggccacgaac tgggcaacca cacccagcac cacatcgaca
     7201 tctccaccat ggacgagtcg gaggcgtacg ccgagatcac cggctgcgcg gaccgcctgc
     7261 gccggctcac cggctccatc gggacgtggt tccgcccctc ccgtgcccag tacgcgacgc
     7321 cgctcgttca gaaactggcc cggcaggcgg gttacccgca cgtcctgtcg tacgacgtcg
     7381 actcgctcga cttcacctcg cccggcgcct cggccgtgac ccgcaacgtc accgggcaga
     7441 tccgcaacgg atcggtggtg agcctgcact tcggctatgc ggacacggtc gccgcgctgc
     7501 ccgtcctact cgccgaactg gaacgccgcc gactgcgcgc ggtcacgacc acggagctgc
     7561 tgatctgatg ccgaccgcaa cgaagacgac caccgcgctg ctcgccgccg tcctgctcgc
     7621 ggccctcgcc ggctgcggct cgggccccga ccacaaggac gaggcgctca gcaccaaggc
     7681 ggcgctcccg cccgccgtcg tcaagaagcc cgtgccgcag ggcctgcccg ggatgccgcc
     7741 cgtcctcgac cccaaggacg cctacgcggc ggaccggccg aacgcgctgc agcccgcggt
     7801 gaagaacttc ctgccgcgcg tgtacgtgcc caacaccaac tccaacacgg tgtccgtgat
     7861 cgacccggcc acgtacaagg tcatcgagac gatcccggtc ggccaccagc cgcagcacgt
     7921 cgtgccgtcg tgggacatga agacgctgtg ggtcaacaac gacctgggcg actcgctcac
     7981 cgccatcgac ccggcgaccg gcaagaccgg ccgtaccgtg caggtctccg acccgtacaa
     8041 cctctacttc acgcccaacg gcaagtacgc catcgtcatg gcctcgatgg accgcgagct
     8101 cgtcttccgc gaccccgtca ccatgaaccg ggtcaagacc gtcccggtga cctgtgcggg
     8161 cgtcaaccac gcggacttct ccatggacgg ccggtacttc atcgtctcct gcgagttctc
     8221 cggcgagctg ctcaaggtcg acaccgagaa gatgcagatc gtcggccagc agaagctgcc
     8281 gttcgacggg gcgatgccgc aggacgtgaa gatgtccccg gacggcaaga cgttctacgt
     8341 ggccgacatg atggcccacg gcatgtgggt cctgaacggc gacaagttcg acaagccggt
     8401 cctgctgccc accggcaagg gctgccacgg gctctacatc agccgcgact ccaaggagat
     8461 gtacatctcc aaccgtggcg agggcaccat ctccatcttc gacttcacca aggacaagct
     8521 caccaagaag tgggaactgc cggacggcgg cagccccgac atgggcggcg tctccgccga
     8581 cggcaaggtg ctctggctgt ccggccgcta caacgccgag gtgtacgcca tcgacaccgc
     8641 caccggcaag gagctggccc gcatccccgt cggctcgggc ccgcacggcc tcgccgtcta
     8701 cccccagccg ggccgctact cgctcggcca caccggcatc ttccgctgag ccggccccgg
     8761 tccgcaccgc ccccacgtgc cccgaggccc gccggccccg gggcacccgc cggtcaccac
     8821 agcaccggca gccgctccgg caggcgcttg atgaagccgg tgcgccacac cagctgctcg
     8881 gccgggaccg cgaggcgcag ccccggcatc cggtccacca ggaccgagag cgcggtctcc
     8941 gcgtgcagcc ggccgaggcc cgtggccggg cagaagtgcc ggccggcccc gaacgacagg
     9001 tgcggattgt gctcccggtc gaggtccagg cgctcggggt cgctgaagac cgccgggtcg
     9061 aagttggcgc cctcgaccag gacgagcacc aactcgccct tctcgacgag gacttcaccc
     9121 agccgcacgt cctccagggc gagccgcggc agcccgtcgc cgatggacag gttccagcgc
     9181 agcagttcgt ccacggcccg tcccatgcgc tcggggtgct cgcgcagacg gccgatcagc
     9241 tccgggtgct ggagcagggc caggaccgcc aggctcagga acgcggaggt cgagaccgcg
     9301 cccgcgccga acatggacac cgcgaccgtg gccagcatct cgtccgtcag atgcgcggac
     9361 tcccggtcct cgcgcagcgc cccgagccgg ccgagcaggc tgtccggcgg cacatcgggc
     9421 gcgttcagcc gctccaccat gtacccgagg tccttgtacc agttgagccc ggcgccctcg
     9481 aaggtgtgcg cgctcgtcat gaacgcggtg tccaggcccg acatcagccg ccgccagtcc
     9541 gtgaacggaa ccccgatcac ctggcagtgc agcgccgccg agaaggggtc ggcgaacccc
     9601 gcccggaggt cggccggcgg gccctcggtg agcagcgcgt cgacgaactc cccggcccgc
     9661 tcgcgcagcc ggttgacgag accgtcggcg cgcgggctca gggacttcat cacggcggag
     9721 cgcaggcccg cgctgttgat gttgcccatg ttgttgacga cctcgggcgg gatcgtcagc
     9781 gcgtactggc gcgggacgcc cggcgcggcg gtgtccttga ggctgaaccg ctcgtcctcc
     9841 aggacctgtt tggccagcgc gtgactgctc accagccagg cctggtcgcc ggtgagcgta
     9901 cggacccggg ccacgggctg cttctcgcgc agccaggtgc actcctcggg cagcacgtcc
     9961 ccgcggcgcg agagcgggaa gtcgagtacg ggctcggggg tcatgcggct attccttccg
    10021 ggcgcaccac tgcgtaggcc tggttgcggg aggcgcggag cccgccgccc ttggcgtaga
    10081 ggagttcggt cagggggatc ggcgcgtggt agcacgacac cgaggagggg acgccgagga
    10141 tgcccggggt gtccaggaag aaggggagct cggcgacgat gtagtcgagg caggcggaga
    10201 gctgctccgc gctcacggcc ggttcgccgg ccttcgtggc gaggaagtgc gccgccatgt
    10261 gctcacagcc cgcgcggaag tgcgggtcgg tggacaggaa gtgccgcacc cggcggtgca
    10321 gcagctcgta caccgggttc ccggcgaact ccgagagccc gtgcacatcg accggagtgc
    10381 cctgcgggcc cgcgtcctcg atgccgcgca gaatcctgcg gcgtaccgcc ttcagctcct
    10441 tggaggcacg gcgggccgcg tggtcccgct cgtagccgag cgcgctgaac agatcggcca
    10501 catggaggtc ggcgtacacg atgtcgatgc gggagaaccg tgccgaagcc caacggacga
    10561 gttcggtgat gcggccggcg ctgaaatagc tgttacccgg actcacaccg atgaggacgt
    10621 gatcgccctc gtcccatatg tggtggcaac ttcgtgtgaa gggctgcacg gtgaatgctt
    10681 cagttgtgat ggccacagct gtaacgcccc agcgccgcta gtccctgggt gccctgtgct
    10741 cccggtgtgg cggcgacagc atgaagttat ccaccagtgg cggagcgtga ggaagcggcg
    10801 gcgggaagtt ggcgtgaact cccctttgtc gggcggaaaa ctgtcctccg tgtatggcga
    10861 acagtcaggg tcgcgggccc ttgggtgatt cggccgaacg ccggtgcccg caccgccggg
    10921 attccagcgg cgggaaccgg ccatccgccg cggcggcgct caggggccat ccgccgcacg
    10981 gtgcgcgcac atcggcggct aatctgaccg gcgtcagaaa agcaccaagc agtagcacca
    11041 acaaaggggt ggacccagtg gcggacatcg aagaggcgcg caaggcgttc gcgaagctcg
    11101 acgtcgacgg tgacggacgc gtcaccgcga gcgagtacaa ggcggtcatg gcgcagctgg
    11161 gcgacttcca cgtcaccgag accgtggccc aggccatcat cagggccaag gacgccaacg
    11221 gcgacggcaa gctctccttc gaggagttct gggcgtccct gaacaagtga ccccgaccgg
    11281 tgccggtggc gcggaaccgc ccgggcggag cgccaccggt gccgggccgg aataacccgc
    11341 agtggccgtg ggttctcgga gcgtgtcaac gcaccaactc cggaaggcca gctcatgaag
    11401 atcggcatca tcggcgcggg caacatcggc ggcaacctga cccgccgcct caccgcactc
    11461 ggccaccagg tgtccatcgc caactcccgt ggcccacaca ccctttccgc cctcgcggag
    11521 gagacgggtg cgaccccggt caccgtcgag caggcggccg acggcgccca ggtcgtcgtg
    11581 gtcaccatcc cgctgaagaa cgtgcccgac ctgcccaagg acctgttcgg caaggccgcc
    11641 gacggcctcg ccgtcatcga caccgggaac tactacccga aggagcgcga cggccggatc
    11701 gacgcgatcg aggacggcct ccccgagagc cgctggaccg agcagcacat cggccatccg
    11761 gtgatcaagg tgttcaacgg cacgtacgcg caggacctcc tggaccggcc gcgccccaag
    11821 ggcgcccccg accgggtcgc cgtgcccgta gccggggacg acgcggccgc caagcagctg
    11881 gtccgcgagc tcgtcgacga gctgggcttc gacaccgtgg acgcgggcgg catcgacgac
    11941 tcctggcgcc agcagcccgc cacccccgtc tacggcctgc gcggcaacac ggccgaggtc
    12001 accgaggccc tggcggcggc ccccaaggag cgcccggcgg cgcactccgc ctgagcggag
    12061 ccgggagacc ggctcagcac tcgatgatgt tgacggcgag gccgccgcgg gccgtctcct
    12121 tgtacttgac gctcatgtcg gcccccgtct ccttcatcgt cttgatgacc ttgtccaggg
    12181 acaccttgtg gctgccgtca ccgcgcatcg ccatcttggc ggcggtgacg gccttcaccg
    12241 cggccatgcc gttgcgctcg atgcacggga tctggaccag gccgccgacc gggtcgcagg
    12301 tcaggcccag gttgtgctcc atgccgatct cggccgcgtt ctcgacctgc tcgggggtgc
    12361 cgccgagcac ctcggcgagc gcgcccgccg ccatcgagca ggcggagccg acctcgccct
    12421 ggcagccgac ctcggcgccg gagatcgagg cgttctcctt gaacagcatg ccgatcgcgc
    12481 cggcggcgag caggaagcgg acgatgccgt cctcatcggc tccgggcacg aagttcatgt
    12541 agtagtgcag gaccgccggg atgatgccgg ccgcgccgtt ggtgggcgcg gtcacgaccc
    12601 ggccgcccgc cgcgttctcc tcgttgaccg ccatcgcgta cagcgtcgcc cactccatgg
    12661 cgtgcgcctc ggggttgccc tcggcgcgca gcaggcgggc ggtgttggcg gcgcggcggc
    12721 ggaccttgag gccgccgggc aggatgccct cgcgggacat gccgcgcgag acacaggcct
    12781 gcatgacccg ccagatgtcg aggagcccgg agcggatctc gtcctcggtg cgccacgcct
    12841 tctcgttctc cagcatcagc gcggagatgg agaggcccgt gtcctgcgcg aggcggagca
    12901 gttcgtcgcc ggtgcggaag gggtgccgca ggacggtgtc gtccggcacg atcgggttct
    12961 cgccggccac ggcgtcctcg tcgacgacga agccgccgcc gaccgagtag tacgtcttct
    13021 ccaggagcag cgcgccgtcg acgtcgtacg cgaagaccgt catgccgttg gcgtggtagg
    13081 gcagcgcctt gcggcggtgc aggaccaggt cgtcgtcgta ggcgaagccg atctcgtgca
    13141 tgccgagcac gttgagccgc ccggagtcct tgatcttctc cacccgcgcg tcggcgttct
    13201 ccacgtcgac cgtgcgcggg gacgcgccct ccaggccgag cagcaccgcc ttcggggtgc
    13261 cgtggccgtg gccggtcgcg ccgagcgagc cgtacagctc ggaccgtatc cgcgcggtgt
    13321 gggcgatgag gccctcgttc ttgagccgcg cggcgaacat ccgggccgcg cgcatcgggc
    13381 cgacggtgtg ggagctggac gggccgatgc cgatcgagaa caggtcgaag accgagatgg
    13441 ccacgggaga ctccttgtgg gggttggtag acgccgttgt ctgccggggt atcgcagagc
    13501 aaagctggca cagcatggga tggggcaccg cgctcactac ccagtgtgcg cggtgccccg
    13561 gggcttcgta cggaatgaac cgagaacgaa agcgtacgaa actacttcag gccggggtac
    13621 agggggtgct tcgcggccag agcggacacc cgggcggcca gggcgtcctg gtcgaagtcc
    13681 ggcttcaggg cctcggcgat gatgtcggcg acctcacgga agtcgtcgtc gccgaagccg
    13741 cgggtggcga gcgccggggt gccgatccgc aggcccgagg tcaccatcgg cggccgcggg
    13801 tcgttcggga tggcgttccg gttgaccgtg atgcctacct cgtggagacg gtcctcggcc
    13861 tgctggccgt ccagctccga gttgcgcagg tccaccagga ccaggtgcac gtcggtgccg
    13921 ccggtcagga cgtcgacgcc gacggcccgc acgtcgtcct ggaccaggcg ctcggccaga
    13981 atccgggcgc cgtccagggt gcgctgctgg cgctccttga actcgggcga ggccgcgacc
    14041 ttgaacgaca ccgccttcgc cgcgatgacg tgctccaggg gaccgccctg ctgacccggg
    14101 aagaccgccg agttgatctt cttggcgagc tcctgcgtcg acaggatgac accgccgcgc
    14161 ggaccgccga gggtcttgtg cgtggtggtg gtcacgacgt gggcgtgcgg caccgggttg
    14221 gggtgcagac ccgcggcgac caggcccgcg aagtgggcca tgtcgaccat caggtacgcg
    14281 ccgacctcgt ccgcgatgcg gcggaaggcg gcgaagtcca gctggcgcgg gtacgcggac
    14341 cagccggcca cgatcagctt cggcttggac tccttggcca ggcgctcgac ctcggccatg
    14401 tcgacctcgc cggtctcgtc gacgtggtac gggaccacgt tgtagagctt gccggagaag
    14461 ttgatcttca tgccgtgggt caggtgaccg ccgtgggcca ggttcagacc catgatcgtg
    14521 tcgcccggct tgagcagcgc gaacatcgcg gccgcgttgg cctgggcgcc cgagtgcggc
    14581 tgcacgttgg cggcctcggc gccgaacagc gccttgatgc ggtcgatcgc gatctgctcg
    14641 accacgtcga cgtgctcgca gccgccgtag tagcggcggc ccgggtagcc ctcggcgtac
    14701 ttgttggtga ggaccgagcc ctgggcctcc atgaccgcga ccggagcgaa gttctccgag
    14761 gcgatcatct cgagggtgga ctgctggcgg tggagctcgg cgtcgacggc ggcggcgacg
    14821 tccgggtcca gctcgtggag gggctggttc agaagcgaca tcagacgatc ccttgaatcc
    14881 cttgtcccag tggcctgggt cagctggcga agtcggtgta ctcgtcggcg gagagcaggt
    14941 cgcccggctc gtccgtgacc ttcaccttga acagccaacc gccctcgaac ggggccgagt
    15001 tgacgagcga ggggtcgtcc acgacgtcct ggttggcggc gacgacctca ccggtgaccg
    15061 gggagtacag gtcgctgacc gacttggtgg actccagctc gccgcaggtc tcgcccgcgg
    15121 tcaccgtgtc acccacctcg gggagctgga cgtacaccac gtcaccgagc gcgttggccg
    15181 cgtgctccgt gatgccgacc gtcgagacgc cgtcctcggc gctcgacagc cactcgtgct
    15241 ccttgctgta gcgaagctgc tgcgggttgc tcatgacctg aattctcctg tacgcggggg
    15301 agtgctggtg acggggtctg gacgagtgtc tcggacggcg agacgggaaa ggggctgccg
    15361 gacggaggcg ctcgtcactt ctggcgcttg tagaagggca gcgcgacgac ctcgtacgcc
    15421 tcgtgcgtgc cgcggatgtc gatgccgaca cctccggtgc cgggcgcggc gtgcgcggcg
    15481 tccacgtatg cgatcgcgat cggcttgccg agcgtcgggg agggggcgcc cgaggtgacc
    15541 tcgccgacga cctcgccgcc ggccaccacc gagaacccgg cgcgcggcac ccggcgcccc
    15601 tcggcgatca ggccgaccag cttgcgcggc gggttggcct cggccttctc ggcggcggcc
    15661 tccagcgcct tgcggccgac gaagtcgccg tccttctcga acttcacgac ccggccgagc
    15721 cccgcgtcga acggcgtgag cgcggtcgtc agctcgtgcc cgtacagcgg catgcccgcc
    15781 tcgaggcgca gcgtgtcgcg gcaggacagg ccgcacggca cgaggcccgc gccctggccg
    15841 gcgtcggtca gcgcccgcca cagctgctcg gcgtgctccg gcgccacgaa cagctcgaag
    15901 ccgtcctcac cggtgtagcc ggtgcgggcg atcagcgcgg gcacaccggc gaccgtgccg
    15961 ggcagaccgg cgtagtactt caggccgtcg aggtcggcgt cggtgacgga cttcaggatg
    16021 ccgggggact cggggccctg caccgcgatg agcgcgtagg cgtcccggtc gtcgcggacc
    16081 tcggcgtcga agccggccgc gcgctcggtg atcgcgtcga gcacgatctg cgcgttgccc
    16141 gcgttggcga cgaccaggta ttcgggggcc tcggtctcgc ccaggcggta gacgatcagg
    16201 tcgtcgacga tcccgccgtc ctcctggcag atcatcgtgt accgggcgcg gccgaggccg
    16261 atggtggcga tgttgccgac cagcgcgtag ttcagcgcct tcatggcctc ggggccggtg
    16321 acggtgatct cgcccatgtg ggacaggtcg aagagcccgg cgcgggtgcg cacggcgttg
    16381 tgctcgtcgc gctcgctccc gtaccgcagc ggcatgtccc agcccgcgaa gtcggtcatc
    16441 gtggcgccca gcgaacgatg cagggcatcg agggaggtca gacggggggc gttgctcatg
    16501 gatgttgctc caaggtcccg gggcatgacg gtcgaggaca tcctccccat ctgtcatcgg
    16561 aacctgagag gttcaccgtc gcgcgctgcg cggcacggct tgcaccttgg gtgggaccgc
    16621 ccggcagggg acggtccgct tttcagatct gcctcgtccg cgcggtacgg ggcctgagag
    16681 attcaaggga ggaacttgct ccttcggcgc cccagctcac agctgctgag gactctcccg
    16741 cgcggattcg aacggccggt atgcagttgg cgcgcacatc attgcacgca tcccggaagc
    16801 ggcaaatcgc ttgagcccta ttaccgtctc tttacacttc cagggcaggg gtcccggaat
    16861 ccgaacaggg gggagtgcca tgacggttgg acacggaacg ggccggacgc gggaggcgcc
    16921 ggaggcggaa gggccggggc gggcggcacg ggaccggccg ccgcgcccgg tgatgagcga
    16981 ggcggtgcgg gacctgcgcg ggcggcccgg gcgcaccccg cccgagctgc tcttcgacgc
    17041 gggggacgtc gtggtggtgt cgggtctgcc cggaagcggc aagacgacac tgatgcgccg
    17101 caccgtcacc gaccgccgca tcgactccca ggacacccgg ctcgcgtggc agcgccggct
    17161 ccccggcatc ccgtacgccc tctaccgccc gctcacccgc accgcgcact tcgccaggac
    17221 ctggtgggcg ctgcgctccg gcgacagcct cgtcgtgcac gactgcggga cgcaggcctg
    17281 ggtgcggcac tggctgggcc ggggcgcccg gcgccggggg cgcgcgctgc gcctggtcgt
    17341 gctcgacgtg gcgcccggca ccgccctgga gggccaggcc gcccggggcc gctgggtgtc
    17401 caggtacgcg ttcgcccggc accgcggcgc ggcccgccgc ctcatagccc aggtggaggc
    17461 cggacggctt ccgaccggct gcgcgagcgc ggtgctgctc gaccgcgagt cggcgtcggt
    17521 actgcaccgc atcggcttca cgaagtagcg ccgcatggcg tccgccgggc ccattcccgg
    17581 caccctttcc gcggcgcgcg tcggcggcgc tagggtcgag gggcacgaca gcagtcgggg
    17641 gagaaggacg gcacatgaac tttccggagc aggcgttcgc gcatccgcac ggcggcgggg
    17701 gatggcccgg caacgagctc gaagaggtcc tgtccgcggc cgtcgggcag cccgacgcgg
    17761 gcccccgcct catagaggtg ctcggccgca accccgtatg ggtgccgctg cccaacggcg
    17821 gcagccagga cagcagggac ctcgacctgc ccaccatgga gctcgacggc gctccctatg
    17881 tgccggtgta cagctccgag cagcagttcc tgcgctgcgt cggctcccac atgtcgttcg
    17941 ccgtcgcccc cgccgtcgag ttcgcgcgcg ggctgccacc gcagctcggc atcgtcgtca
    18001 accccgaggg cgcggtgggc atgccgctgc ctccgcccgc cgtcgccgag ctgtgccgca
    18061 ccggactcac cgcgctcgac gggcccgcgt cgggcgcgcg ggtgcggctc ttcgagccgg
    18121 actggcagga ggagccggtc gacttcctgg ccgtcgcggc cgaggagttc gaggcgatcg
    18181 gcgtggtgct cagcgcccgc cgcgcgctcg cctccatcga gggcgagtcg cccacgctct
    18241 tcatcggcgt ggagttcgcc acctgggacg gggcggggcg cggcgccccc atggaggcgc
    18301 tcggccgggc gctcggccgg gtcccggtcg gctggccggt caatctggtc ctgctcgacg
    18361 tgacccagga tccggtcgcc acctggatgc gcgagcgggt acggcccttc tacgcacggg
    18421 cccagtagca accaccgggt gcgtcgcggc agctcccgcc gggtcatggc ggtgtctgta
    18481 cggcggctta acctggtttc atgacccttg cacccccgca gccgcacgcg tgtgcccggg
    18541 gctgcggggc ggcgcaggcg tcggcacggt ggatcgaaga ggggcgggac ccagggtgag
    18601 cgcgtcaggc accgcggcgg ccgggcaggt cgagcacatg ctgcgccagg tgacccccgg
    18661 gcgctacgac gtgtacgagg cgctgctcca cgcgctcgcg gaccccgcgt ccggccggat
    18721 ctggatgctg ctgtggaacg gccggccggg ctccccggac gcgcagtacg gaaacatgga
    18781 ggtcgacggc gtctcctacg cgccctgtgt cacctccgcg caggagctgt ccgccagcgg
    18841 ctggaaccgg gagcacgaag tgagcggcgc gctcgacatc gcccgctcgc tctaccccga
    18901 ccgctacggg atctggctca atccgcacgc ccccggcggc ggcgtcggca tcccctggac
    18961 ggatctgcgc cggatcgcca ccggcctcga ccggatgccc gcgggaccgc tgcggctctc
    19021 cgaaccggcc gtggagatcc cgcagttcta cgccctgctc gcgcagcacg cgcaccgcac
    19081 cccggccgtg cgctcactgc gccgcgcctg ggtgcagccc gcgctcggca cgccgtacct
    19141 ggcgatcggg ctcgacctct acgacaccgg tccgcagtcg gtggacgcgg tgcgggcgat
    19201 gatgcagcag tccatccccg cggtgccgga cggcctcgcc gtctccaccg tcgcgatgtc
    19261 cgacgcgtac gacccggtcg gcatgtggct gaaagccgcc acgcggccct tctacgaccg
    19321 cgaggcgcac gccgccccgg cccccggcgg gcccggctac ggctacccgc cggccgcccc
    19381 ccgcacgtac tgaccccccg cacgtactga cccgcgtacc ggggccgccc cgcgcatggg
    19441 ggtgtgtccc gttcggcgcc ccaaccggga cagacccggc caactcccct cacgcgtaag
    19501 gggaatgtcc gttctgatgg ggcgaacgcc gcaatggtcc agcgcgtcgc ttgcgcccca
    19561 acttccgcat gtccgcccct ggttcacctg cgtccgcata acggaaaccc tctttccgca
    19621 tcacgtttac gcatacattc gccgccaggt ctggcgggtg atcgcgacgc cattgaagac
    19681 tcccggcatg cagggccgtt cgggcccttg tgcgagcagc tcgacccgct gcccggtgtc
    19741 gccccccgct cgcactgctg atgggaacgc gccgctacag cggcaagtgc gggccggtca
    19801 ccgccggttg agaggggtcc ttgccacgat gacggcacca ttgcacgaca cacccgccga
    19861 cgcggacccg accgcggaca tcagtgtcac gccgagcggc gagaccagag cggtcgaggg
    19921 acgttcgctg ggccgcatcg cctggaaccg gctgaagaag gacaagctcg ccctcaccgg
    19981 tggcatcgtt gtcgtgttcc tggtcctcgt cgcgatcttc gctccgttga tcgtcgacgc
    20041 gttcgggcac ccgccggacg acttccacga ggaccagatc gacccgctgc tctcgacccc
    20101 ggtgggcagc tggggcggca tcaactcgca cttcctgctg ggtgttgagc cggtcaacgg
    20161 gcgcgacgtg ttcagccgca tcgtctacgg cgcgcgcatc tcgctcctcg tgggcttcct
    20221 cgcggccgtc ttcgcggtcc tggtcggcac cgtcctcggc gtgatcgccg gatacttcgg
    20281 cggctggctc gacgccatca tcagccgcgt gatggacatg ctgctctcct tcccgcagct
    20341 gctcttcatc atcgcgctga tctccgtggt ccccaaccag ctcttcggcc tcaacggcac
    20401 cggggtccgg ctgctcgtga tgatcctggt gatcggcttc ttcgggtggc cgtacgtcgg
    20461 acgcatcgtg cgcggccaga cgctgtcgct gcgcgagcgc gagtacgtcg aggcggcgcg
    20521 cagtctcggc gcgggccgcg gctacatcct gttccgggag ctgctgccca acctcatcgc
    20581 gccgatcacc gtctacatga cgctgatgat ccccacgaac atcctcaccg aagcggcact
    20641 cagcttcctg ggagcgggcg tcaagccgcc cacggcctcc tgggggcaga tgctct
//
