LOCUS       NZ_BMUU01000011        10228 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence11, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000011
VERSION     NZ_BMUU01000011.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 276868)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 164910
            Orig. end                         :: 175138
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10228
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10228
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5228](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5228)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    474..489
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     gene            complement(1818..4094)
                     /db_xref="GeneID:96293592"
                     /locus_tag="IE233_RS27865"
                     /old_locus_tag="GCM10010326_56740"
     CDS             complement(1818..4094)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96293592"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157698.1"
                     /locus_tag="IE233_RS27865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56740"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_190028598.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.7e-37, bitscore:
                     121.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHASPPTPHLPAGHGRRRPANTPSDGRRSRARQAPKARPAKV
                     VRSPTVLQMEALECGAASLAMVLAHHGRHVPLEELRIACGVSRDGSRASNVLKAARGYG
                     LTAKGMQMEPAALAEVQAPAILFWEFNHYVVYDGTGRRLGRRGVHINDPDKGRRFVPSE
                     DFDTSFTGVVLVLEPGPDFRPGGRKPGVLGALPARLRGTTGTMLAALLASLLLVAVGAT
                     LPALSRTYIDLFLIGHQTSLLGVLFAAMGLMVVLTVVLTWLQQANLLRGRIISSTLSSA
                     RFFRHLLRLPVTFFAQRSPADLVQRLQSNDAVAETLARDLTAAAVDGVVVLLYAVLLWT
                     YDPQLTVVGVGIALLNVVAMRIVVRLRATDTQKLRADSARLTNTSYTGLQLIETMKATG
                     GENGYFRRWAGQHATTLEVQQRLGVPSAWLGVVAPALATLNSALILWIGGLRAVEGHLS
                     IGLLVAFQALVTRFTAPVTRLNGVAGRIQDFAADVARLKDVENFPADALHSRPEPPAST
                     RRLKGHVTLDDITFGYSPLDKPLLTGFSLTVGPGQQVALVGGSGSGKSTVSRLISGLYA
                     PWEGTIRIDGRRLEDIPRGALAASVSFVDQDVFLFEGTVRDNVALWDPSIPDDAVVLAL
                     RDAELYDDVARRPGGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDA
                     ETEHLIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHEDLVGAAGPYAR
                     LVREH"
     gene            complement(4091..4897)
                     /db_xref="GeneID:96293593"
                     /locus_tag="IE233_RS27870"
                     /old_locus_tag="GCM10010326_56750"
     CDS             complement(4091..4897)
                     /codon_start=1
                     /db_xref="GeneID:96293593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="IE233_RS27870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56750"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_190028599.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEELDLPVRFARPQGRLVLFVTVVVMAAASFW
                     AVTGSVSSTIDAPGILTHAQGSYVLQSPVAGQVTGVLAKEGESLAADAPLLKVRTAQGE
                     RTVRAIAAGRLTSLAATIGAVVATGSNVASVERTGGADDPLTVMLYVPGDRAASVPVGA
                     PVDLTVQSVPADRYGVLRGTVAAVGRTAQTPQQIAAFLGDGQLAEQFARDGRPVGVAVR
                     LDRAPGTKSGYRWSSADGPPYAVDSMTPATGTVHLADRRPIDWLLP"
     misc_feature    4862..4874
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.61"
                     /tool="antismash"
     misc_feature    complement(4942..4960)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.93"
                     /tool="antismash"
     gene            complement(5001..5228)
                     /db_xref="GeneID:96293594"
                     /locus_tag="IE233_RS27875"
                     /old_locus_tag="GCM10010326_56760"
     CDS             complement(5001..5228)
                     /codon_start=1
                     /db_xref="GeneID:96293594"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157700.1"
                     /locus_tag="IE233_RS27875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56760"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_161250366.1"
                     /sec_met_domain="strepbact (E-value: 5.2e-30, bitscore:
                     97.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNAPQVETLEISDADLDNVSGGLVGTALGNVTGTADSVLPVSGI
                     VNSVTGLVGSTTGVNTGAVTGLATGLVAGL"
     misc_feature    5291..5304
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(5300..5309)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     gene            5720..6175
                     /db_xref="GeneID:96295852"
                     /locus_tag="IE233_RS39745"
                     /old_locus_tag="GCM10010326_56770"
     CDS             5720..6175
                     /codon_start=1
                     /db_xref="GeneID:96295852"
                     /inference="COORDINATES: protein motif:HMM:NF036395.5"
                     /locus_tag="IE233_RS39745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56770"
                     /product="luciferase family protein"
                     /protein_id="WP_308432630.1"
                     /transl_table=11
                     /translation="MDQLESWPNLVSGPPRCAVGQALFAAECEVVHFHSGFAVDLHLTH
                     PAIERLRPELRHSTAIRLKPGSAWVTVLLDCGADVDLLLTLVSMALKAQALSPPNALAA
                     PCTWYRPAVPPQRVADPPVLTLGPRPGVLPAARRAVGRFLPHGPRAV"
     gene            complement(6263..7315)
                     /db_xref="GeneID:96293595"
                     /locus_tag="IE233_RS27885"
                     /old_locus_tag="GCM10010326_56780"
     CDS             complement(6263..7315)
                     /codon_start=1
                     /db_xref="GeneID:96293595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660526.1"
                     /locus_tag="IE233_RS27885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56780"
                     /product="chitinase"
                     /protein_id="WP_161245319.1"
                     /transl_table=11
                     /translation="MIGRTLRLLGAGLVLALATQVPVAAAPSAPQADTCAVKSRPSGKV
                     LQGYWENWDGASNGVHPPLGWIPITDARIAAHGYNVINAAFPVIRSDGTVLWQDGMDAT
                     VKVPTPAEMCQAKASGQTILMSIGGAAAGIDLSSSAVADRFVASIVPILKQYNFDGIDI
                     DIETGLVGSGNINTLSASQANLIRIIDGVLAQMPAGFGLTMAPETAYVTGGSVTYGSIW
                     GAYLPIVKKYADNGRLWWLNMQYYNGSMYGCSGDSYEAGTVAGFTAQTSCLNKGLVVQG
                     TTIKVPYDKQVPGLPAQPGAGGGYMTTSQVAQAWNTYGGGLKGLMTWSLNWDGSKNWTF
                     GNNVKALQGR"
     misc_feature    complement(7298..7300)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(7418..7433)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.25"
                     /tool="antismash"
     misc_feature    complement(7499..7517)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
     gene            complement(7527..8219)
                     /db_xref="GeneID:96293596"
                     /locus_tag="IE233_RS27890"
                     /old_locus_tag="GCM10010326_56790"
     CDS             complement(7527..8219)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96293596"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957673.1"
                     /locus_tag="IE233_RS27890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56790"
                     /product="HAD family phosphatase"
                     /protein_id="WP_161245320.1"
                     /sec_met_domain="HAD_2 (E-value: 1.7e-37, bitscore: 123.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSHNTSVIFDLDGTLVDSEPNYYEAARQVLARYGLPDFSWEQH
                     ARFIGIGTRETLEILDRQHTLTGPIEEMLAAKNAAYLELARTSTEVFPEMRAFVERLHA
                     DGVRMAVASGSSRSAIDAVLAGTGLAPFMDLVVSAEEVERGKPEPDVFLEAARRLGAAP
                     ADCVVLEDAPPGAAAAHAAGMRCIAVPYLPQSSGDPAFATAGLLFPGGQREFSAERAYA
                     WLGAPSTA"
     misc_feature    8201..8210
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.12"
                     /tool="antismash"
     gene            complement(8260..8736)
                     /db_xref="GeneID:96293597"
                     /locus_tag="IE233_RS27895"
                     /old_locus_tag="GCM10010326_56800"
     CDS             complement(8260..8736)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96293597"
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069408.1"
                     /locus_tag="IE233_RS27895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_56800"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_161245321.1"
                     /transl_table=11
                     /translation="MTVDTLDTRILRLLIEQPRTSIREYARLLGIARGTLQARLDRMER
                     DGVITGTGPMLSPAALGHPVLAFVHIEVTQGHLDEVGDALAAVPEIIEAFSITGGGDLL
                     TRVAARDNAHLEDVIQRLIQLPGVVRTRTEVALRERVAHRLLPLVESVGRAAAK"
     misc_feature    complement(9605..9618)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
ORIGIN
        1 cgaactcccc ggcccacgcc ccgtacgcga agctctccgc cgcggcgacc cgcagcttgg
       61 gcagcccgcg cagggtctgg aacgcctggt tgttgagcct gttgcccagc tccacgaggc
      121 ggcgctgcca gcgcagctcc cacatcccga gcgcgaggaa cacggcggcg atgacgacca
      181 gaagggcgat cgcgaccaac gccagcggca cgctgaagca cagcagcaga gccaggttca
      241 tcgcgccgac cgtgcccgcc tgcaccgcga ccgggccgat cccggaaagg acccgccgga
      301 tcgcgctcac gcccatcgcg gcgctcgcca gctcgccggt ggaacgcccg gcgaagaacg
      361 tggtcggcag tctcaacagc cggtcccaga cggcgggttg aagggtgctc tcgatccggc
      421 cctccatgcg gagcacggtg aggttctgga gcagcgtgaa cgcggccgac accacgccgg
      481 tgacgatcac ggcgagcgag acctgcacga tgaggccgtt ctgcgcccgc ggcacgtaca
      541 ccccgagcac ctgaccggtc gcgatcggca cgagcgagcc gagccccacc gtcaccagac
      601 cggcgagcag cagcctgcgc acgtcggggc ggctgccgcg cagcccgaac cggagcagcc
      661 cccaccggcc cagcgggcgg tccggcagcg gccggtagaa catcacggcc cgccgctcga
      721 actcctcggc gttgcccgcg tccacccggg tgcgccgccc ggacaccgga tgcaccgcct
      781 cgtagccgcc gcgtcgccac agcagggcga ccggggtgcc gctcgtgcgg tggccgacga
      841 gcggcccggc gtcctcgcgc caccagcggc cgtcgagccg caccggccgg gtgcggacgc
      901 gcgaggcgac ggcgacccgc tcgaccgggt cgatccggtc gctgaccgca ccgccgaggg
      961 ccgggtcgcc gagggtgatc ccggccgcct ccgcgaccag gcggcaggcg gcgtacgtcg
     1021 agtcgtcgga cgccgccgca cgtgaactcg ccctgccggg ccggccgatg gaggtgagca
     1081 gcgcccggtc cgcctcctcg cggaccgcct caccggcctt gatcccggcg gccgcgcggt
     1141 cctcgtgggc acgctccacc cgctcgatcc agcggtcgag cgcggcgagc agccggtact
     1201 gctggttgac catgccctgc cacaagccac cgtcgacgag caggtccccg gccgcctccg
     1261 cgctgaaggc cgccccgtac tgcacgctgc ccggcgccac cggaagccac aggatgtcgt
     1321 cgtccgccac cgactcgtcc agcggggtgc ggccgtccaa cggggcttcg aacaggactc
     1381 gttggccccg accgacgccg agcgagaagg cgtgctccag gaggctgagg gccgcgtccc
     1441 cggtgtcgta ccggctgagg ccgccgtcgt ggccgccgga ttgcggatgc cggtagagct
     1501 cgcgcagcgg aatgcggcgc agcacgcact cccgcagcgg gcgcccgacc agggtgtgct
     1561 gcgggccctc gacggggccg agcagcaggg tgcccggttc gagccggccg aggaagtgcc
     1621 actggccctg ctccgtcgcg tccaccgcga acaggtcgag ggcgccgctc accaccagcc
     1681 acagcacctg cggcccttcg agggagaagc cgcgcagccc ggcgcagtcg acgccctgcc
     1741 ccaggccgcc gagcgcgccg accacggcgt cctgaccggc ggtgcccggc tgggccaggg
     1801 gatgtacgga gctcatctca gtgctccctc acgagccggg cgtacggccc ggccgcgccg
     1861 acgagatcct cgtggcggcc ccgctccacg accgtgccgt ggtcgagcac cacgatctcg
     1921 tcgctgtcgc ggaccgtgct cagccggtgc gcgatgacga cgcaggcgca gccccggcgg
     1981 cgcaggttgt cgatgatgag gtgctcggtc tccgcgtcca gggcactggt gacctcgtcg
     2041 aggaccagga tgctggggcg ccgcaccagc gcccgcgcga tctccaggcg ctggcgctgg
     2101 ccgccggaga agttgcgccc gtcctgctcg acccggctgt ggatgccgcc gggccgccgc
     2161 gcgacgtcgt cgtacagctc cgcgtcccgc aacgccagga ccacggcgtc gtccgggatc
     2221 gaggggtccc acagtgccac gttgtcccgc accgtgccct cgaagaggaa gacgtcctgg
     2281 tcgacgaagg agacggaggc ggcgagcgcc ccgcgcggga tgtcctccag gcgccggccg
     2341 tcgatgcgga tggtgccctc ccagggggcg tacaggcccg aaatcagcct ggaaaccgtc
     2401 gacttgccgc ttcccgagcc gccgaccaga gccacctgct gacccggccc gacggtcagc
     2461 gagaacccgg tgagcagggg cttgtcgagc gggctgtagc cgaaggtgat gtcgtcgagt
     2521 gtcacgtggc ccttgagacg gcgggtgctc gcgggcggct ccgggcggct gtgcagcgcg
     2581 tccgcgggga agttctcgac gtccttgagc cgggcgacgt cggccgcgaa gtcctggatc
     2641 cggcctgcca ccccgttcag ccgggtcacc ggcgcggtga agcgcgtcac cagggcctgg
     2701 aacgcgacga gcagaccgat cgacaggtgc ccctccaccg cccgcagccc gccgatccac
     2761 agaatcagcg cactgttgag ggtggcgagc gcgggcgcca ccaccccgag ccaggcactc
     2821 ggcaccccga gccgctgctg cacctccagg gtggtcgcgt gctggcccgc ccagcgccgg
     2881 aagtacccgt tctcgccgcc ggtggccttc atggtctcga tcaactggag cccggtgtac
     2941 gaggtgttgg tgagccgggc gctgtcggcc cgcagcttct gggtatcggt ggcccgcagc
     3001 cgtacgacga tgcgcatcgc gacgacgttg agcagcgcga tgcccacccc gacgacggtg
     3061 agctggggat cgtaggtcca cagcaggacg gcgtagagca gcacgacgac gccgtccacg
     3121 gccgccgccg tcagatcgcg ggccagtgtc tcggccaccg cgtcgttgga ctgcagccgc
     3181 tgcacgaggt cggcggggct gcgctgtgcg aagaacgtga ccggcagccg cagcagatgc
     3241 cggaagaagc gggcgctgct gagcgtggag gagatgatcc gcccgcgcag caggttggcc
     3301 tgctggagcc aggtcagcac cacggtgagc accaccatca ggcccatcgc ggcgaacagg
     3361 actcccagca aagacgtctg atgacctatc aggaacagat cgatgtacgt gcggctcagc
     3421 gcggggagcg tcgcgccgac ggccaccagg agcaggctgg cgagcagtgc ggccagcatc
     3481 gtgcccgtgg tgccgcgcag ccgggcgggc agcgcaccga ggacaccggg cttcctgccg
     3541 ccgggccgga agtccgggcc gggttccagg accaggacga cgccggtgaa gctcgtgtcg
     3601 aagtcctccg acggcacgaa acggcggccc ttgtccgggt cgttgatgtg cacgccccgc
     3661 cgccccagcc gacggcccgt gccgtcgtac acgacgtagt ggttgaactc ccagaacagg
     3721 atggcgggtg cctggacttc ggcgagggcg gccggctcca tctgcatgcc cttggcggtg
     3781 agcccgtaac cgcgcgccgc cttcaggacg ttgctcgccc gcgagccgtc gcgcgagacg
     3841 ccgcaggcga tgcgcagctc ctccaggggc acatggcggc cgtggtgggc gagcaccatg
     3901 gcgagggagg cggcgccgca ctccagggcc tccatctgga ggaccgtggg gctgcgcacc
     3961 accttggcgg gccgggcctt cggtgcctgc cgcgcgcgcg aacggcggcc gtccgaaggg
     4021 gtgttggccg ggcgccgccg gccgtgcccg gccggcaggt ggggggtggg gggtgaggcg
     4081 tggggtgcgg tcacgggagc agccaatcga tggggcgccg gtcggcaagg tggacggtgc
     4141 cggtggccgg ggtcatggag tcgaccgcgt agggcgggcc gtcggccgac gaccagcggt
     4201 agccggactt cgtgccgggc gcccggtcca ggcggaccgc gacccccacc ggcctgccgt
     4261 cccgcgcgaa ctgctcggcg agctgtccgt caccgaggaa cgcggcgatc tgctggggtg
     4321 tctgagccgt cctgccgacc gcggccaccg tgccgcgcag caccccgtag cggtcggccg
     4381 gcacggactg cacggtgagg tcgaccgggg cgccgacggg gacgctcgcg gcacggtcgc
     4441 ccggcacgta cagcatgacc gtcaacgggt cgtcggcgcc gcccgtccgc tcgacgctcg
     4501 ccacgttcga gccggtggcg acgacggcgc cgatggtggc ggcgaggctg gtgagccggc
     4561 ccgcggcgat cgcgcggacg gtccgttcgc cctgcgcggt gcggaccttg aggagcgggg
     4621 cgtcggcggc caggctctcg ccctccttgg cgagcacgcc ggtgacctgg cccgcgaccg
     4681 ggctctgcag gacgtaactg ccctgggcgt gcgtgaggat gccgggtgcg tcgatcgtgg
     4741 aggaaacgga gcccgtcacg gcccagaaag aggcggcggc catgacgacc acggtgacaa
     4801 agagaacgag tcgtccctgc gggcgtgcga aacgcaccgg caggtcgagt tcctccggtg
     4861 actgcagttt ggaaagggcc tgctgacgaa actgcacgga actctttcct tacccgttcc
     4921 ttgcccgcga aacttccgca aagcgtgaac cattcgcaag gagccccgga accgagcggt
     4981 tccggggctc gtgcgcgatc tcagagaccg gcgacgagac cggtggccag gcccgtgacg
     5041 gcacccgtgt tcacaccggt ggtcgaaccg accaggccgg tgaccgagtt gacgatgccg
     5101 gagaccggaa gaacggagtc ggcggtgccg gtcacgttgc cgagggcggt gcccacgagg
     5161 ccgccggaca cgttgtccag gtcggcgtcg gagatctcga gggtctcaac ctggggagcg
     5221 ttgttcatgg tgagtactgc ctttcatggg gacatttcct atcgggaact ccttgccggg
     5281 gctcccgcag tggccaggat caaaacacgc cgacggcggc ggcagccaat cggcgggggg
     5341 atggacaggg ctttcttccg gccttgaatt gccgtcccgt gcagacccgt tcatgattcg
     5401 ggggcatttc cttcacgagc ttcacgggac gaattccccg ggccccggaa tcgcttctcg
     5461 caactgggac actcccgcac caatgccgcg cgctcccggc ggcgcgggag cgggctcacg
     5521 gccccggtga cgggtccgcg cacgccctgt gcagattctc ggaaggtgtc cctccgcttg
     5581 tctgtggggc acgtcggcca cggtcccggc cgacccccgg gtacggatcg gccacgagac
     5641 gcatcccggg ggtggacggg ggtggtcctg ccggtgaagt gtgcgcgagg atggcgtcat
     5701 gaccgcggct catcgcgcca tggatcagtt ggagtcatgg ccgaacctgg taagtggccc
     5761 gccccgatgc gctgtcgggc aagcgctctt cgccgcggag tgcgaagtgg tgcacttcca
     5821 ctccggcttc gcggtggacc tccacctcac ccaccccgcg atagagcggc tgcgccccga
     5881 gctgcggcac agcaccgcca tccgcctgaa gcccggctcg gcctgggtga cggtcctgct
     5941 cgactgcggc gcggacgtgg acctgctgct cacgctggtc agcatggcgc tgaaggcgca
     6001 ggcgctcagt ccgccgaacg cgctggccgc gccctgcact tggtaccgcc cggccgtccc
     6061 cccgcaacgc gtcgccgatc cgccggtgct caccctcggc ccgaggccgg gtgtccttcc
     6121 cgcggcgcgg cgggcggtgg ggcgtttcct gccgcacggg ccgcgcgcgg tgtgaacgga
     6181 gcgtgcgcag ggggccgccg acaggcggaa gccccgcccg ctggagcgcg gacggggctc
     6241 ggacggtggc cgtttcggac ggtcaacgcc cttgcagggc cttgacgttg ttgccgaacg
     6301 tccagttctt cgagccgtcc cagttgaggg accacgtcat cagacccttg agtccgcccc
     6361 cgtaggtgtt ccacgcctgc gccacctgac tggtcgtcat gtagccgcca ccggcgcccg
     6421 gttgagcggg cagcccgggc acctgcttgt cgtaggggac cttgatggtg gtgccctgca
     6481 cgaccaggcc cttgttgagg cagctggtct gggcggtgaa cccggcgacc gtgccggcct
     6541 cgtacgagtc gccggagcag ccgtacatgc tgccgttgta gtactgcatg ttcagccacc
     6601 acaggcggcc gttgtccgcg tacttcttca cgatcggcag gtacgcgccc cagatggacc
     6661 cgtacgtcac gctgccgccg gtgacgtacg ccgtctccgg ggccatcgtg aggccgaagc
     6721 ccgccggcat ctgggcgagc acgccgtcga tgatgcggat caggttggcc tgcgaggccg
     6781 acagcgtgtt gatgttcccg ctgcccacca ggccggtctc gatgtcgatg tcgatgccgt
     6841 cgaagttgta ctgcttgagg atcggcacga tcgacgccac gaaccggtcg gccaccgcgc
     6901 tcgaactgag gtcgatgccc gcggcggccc cgccgatcga catcaggatg gtctggccgg
     6961 acgccttcgc ctggcacatc tcggcggggg tggggacctt caccgtcgcg tccatgccgt
     7021 cctgccacag caccgtgccg tccgaacgga tcaccgggaa cgccgcgttg atgacgttgt
     7081 agccgtgggc ggcgatgcgc gcgtcggtga tcggaatcca gcccagcggt ggatggacgc
     7141 cgttggacgc gccgtcccag ttctcccagt acccctggag caccttgccc gagggtctcg
     7201 acttcaccgc gcaggtgtcc gcctggggcg cgctcggcgc cgcggccacc gggacctggg
     7261 tggcgagcgc caggacgagc ccggctccca gcagacgtaa cgtacgaccg atcatgctgt
     7321 gctccttgcc tccgggagcg ggcgcgacga ggccgcgcgg ctcctggacc gtggggggac
     7381 ctgaggaggt acgagggggt ggcgccccac accgtagatt ggtccagacc ttccgtcaat
     7441 cgtgccggag gcaccaggtc atggacctgc gggctcatca ggtcccttgc gcacagcggg
     7501 agttgagcct gaccaggctc atgggctcag gccgtcgagg gcgcgcccag ccacgcgtac
     7561 gcccgctcgg cgctgaactc ccgctggccg cccgggaaga ggaggccggc ggtggcgaac
     7621 gccgggtcgc cggagctctg cggcaggtac ggcacggcga tgcagcgcat cccggcggcg
     7681 tgcgcggccg ccgctccggg cggggcgtcc tccaggacca cgcagtcggc gggtgcggcg
     7741 cccagacgcc gggcggcctc caggaagacg tcgggctcgg gcttgccgcg ctcgacctcc
     7801 tccgccgaca ccacgaggtc catgaagggg gcgagcccgg tccccgccag gaccgcgtcg
     7861 atcgcggacc gcgaggagcc ggaggccacc gccatgcgga cgccgtcggc gtgcagccgc
     7921 tccacgaagg cccgcatttc ggggaagacc tcggtcgagg tccgggccag ctccagatag
     7981 gcggcgttct tggccgccag catctcctcg atcgggccgg tcagggtgtg ctggcggtcc
     8041 aggatctcca gggtctcgcg ggtgccgatg ccgatgaagc gggcgtgctg ttcccagctg
     8101 aagtcgggca ggccgtagcg cgcgagcacc tgacgcgcgg cttcgtaata gttcggctcg
     8161 ctgtccacga gggtgccgtc gagatcgaag atgaccgaag tgttatgtga tgtgctcatg
     8221 tgtcccagca tgccaagggt cggcggcgtt ccgcgccgct cacttcgcgg cggcccggcc
     8281 caccgactcc acgagcggca gcagccggtg cgccacccgc tcgcgcagtg ccacctcggt
     8341 ccgggtgcgg acgacgcccg ggagctggat caggcgctgg atgacgtctt cgaggtgggc
     8401 gttgtcgcgg gccgcgaccc gggtcagcag atcgccgccg ccggtgatcg agaacgcctc
     8461 gatgatctcg ggaaccgccg cgagcgcgtc acccacctcg tccagatgcc cctgggtcac
     8521 ctcgatgtgg acgaaggcga gcaccgggtg gccgagggcc gcgggcgaga gcatggggcc
     8581 ggtgccggtg atcaccccgt cccgctccat ccggtcgagc cgcgcctgga gcgtgccgcg
     8641 ggcgatcccc agcaggcgcg cgtactcgcg gatgctggtg cgcggctgct cgatgagcaa
     8701 ccgcaggatg cgggtgtcga gtgtgtccac cgtcatgtcc cgttggctcc ttcctggtcc
     8761 tgcgactggg ccatcgactg taccaatggc ccacccacac ggtgctcggt tgagccactg
     8821 tccccccggg tgttttcctc tggtggtaga tggcgccgcg cagcgcgcgg gacggcgacg
     8881 aagccggtcc gggccccgcg gcgcctttgt catgcctgag accgattgca cgtaaggggg
     8941 cgcggcgacc gccgtgaaga ggatgtttgt ggctccggac ccggggcttc tgcgactgcg
     9001 ggtgtccctg cgagccgtgc tcggcgtggg cctctcggtg accgccgccg aactgtgcgg
     9061 gctctcgctc gccgcgtcga tcaccgccgg cctcgccgcg ctgctcgcgc tgttcaccgt
     9121 tggcgacgcc accgtccgcg cccagatcac caccaccgcg ctgctgcccg ccgtcggctt
     9181 cccggtactc gccctcgcgg ccgcgctgca cggcaccccg acggcgcgcg acgccgcctg
     9241 gctcgtggtg atcttcgccg gggtgtacgc caggcgctgg agcccgcgcg gacatgcgct
     9301 cggcatcttc gccttcatga tgttcttcgc gacccagttc ctgcacgcgg tcacctccca
     9361 actgcccgag ctgtacggcg ccatcgcgct ggcgatcgcc gcctcggcgt cggtcaggtt
     9421 cggtctgtgg tgcatcgagc gccacatcac gcagcccgcg gccccggccc cgctggccgg
     9481 ccggggattt gcccgccaca ccactcggca ggccttccag gcgaccgtgg cctgcggctt
     9541 cgcgctcggt gtgggccaag tgctctccga ggaccgctgg tactgggccg tcggcgccgc
     9601 ctggtggatc ttcgtcaaca ccgcctcgcg cggcgagacc ctggtccgcg gcttccgccg
     9661 ggtcctcggc acggtcgtcg gcatcgtggc cggactgctc atcgcgatcc cgctgcacgg
     9721 ggcaccggcc ccgaccgcgg cgctggtcgc ggtgtgcgtc ttcgggatct tctacacggc
     9781 cgcgccgagc tacagctgga tgatgttctt cgtcaccgtc atggccggcc tgctctacgg
     9841 gctcctcggt gtgctccacc ccgggctcct cgtgctccgc gtccaggaga cggcggtggg
     9901 tgcgctcggc gcggtcatcg gcgtcgccgt cgtgctgccg gtcacgacgc acaccgccac
     9961 cgacgcgtgg atccagcggg ccctgcactg cgtccgccgg tgcaccgcgg cggccgccca
    10021 ccggctcgcc ggggacgaga gcgccgaccc ggcgccccgc gccgccgaac tggagctgct
    10081 gctcatccgg gtgcgcctct cgctcgcccc gctggtccac ccgctcagcc cgcttcgggc
    10141 ccgccgggcc cgtgcccacc aggtcctggt cctgctcgac gagtgcgccc gcgaggtgcg
    10201 gggcctggcc gcggtggccg ccgacccg
//
