LOCUS       NZ_BMUU01000007        10405 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence07, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000007
VERSION     NZ_BMUU01000007.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 403561)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 78746
            Orig. end                         :: 89151
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5405
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    complement(72..85)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    complement(102..112)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    236..249
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    339..354
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            complement(518..1603)
                     /db_xref="GeneID:96292263"
                     /locus_tag="IE233_RS21190"
                     /old_locus_tag="GCM10010326_43380"
     CDS             complement(518..1603)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96292263"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238577.1"
                     /locus_tag="IE233_RS21190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43380"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_190028043.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 6.4e-21, bitscore:
                     69.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDRTVLHVKGRVLAGPEDVRDELWAVDGRITYERPPGEALTVSG
                     WALPGLVDAHCHVGLDQHGPVSEEVSEKQALTDRDAGTLLVRDAGSPSDTRWIDAREDL
                     PKIIRAGRHIARTRRYIRNYAHEIEPGDLVAYVAREARRGDGWVKLVGDWIDRDAGDLA
                     ACWPRGEVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCIEHATGLTEDTIPLFAE
                     RGVAIVPTLVNIATFPHMADGGEAKFPDWAAHMRRLYERRYDTVRSAYDAGVPVFVGTD
                     AGGSLAHGLVAAEVAELVKAGIPALDALSATAWGARAWLGRPALEEGAPADLVVYDQDP
                     RADVRVLAAPSRIVLNGRIVG"
     gene            1719..2816
                     /db_xref="GeneID:96292264"
                     /locus_tag="IE233_RS21195"
                     /old_locus_tag="GCM10010326_43390"
     CDS             1719..2816
                     /NRPS_PKS="Domain: Aminotran_5 (16-310). E-value: 8.4e-30.
                     Score: 95.8. Matches aSDomain:
                     nrpspksdomains_IE233_RS21195_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:96292264"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957694.1"
                     /locus_tag="IE233_RS21195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43390"
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="WP_161247035.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.3e-24, bitscore:
                     79.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPLLDLAPLTADHFAAIERRVAALLATEQDVVIMQGEALLPLE
                     GCIRGAARPGSTALNVVTGPYGQTFGNWLRDCGAEVVDLEVPFHAAVTAEQIDRALTDR
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRRHGALFMLDAVASVAAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSARAWERIAANPSAPRRSYLSLLDWKQRWIDGGRKALLHAP
                     AQLEMLALEACVERIESEGLDAVMARHASAAAATRAGALALGGGLVPYVHEAPDAAPVA
                     TTLRTPEGVDASELVAKALAADPSLPLIAGGGALASTMVRVNHYGVDATRGVVQSSLAA
                     LGAALGEYGIAVDLEAARKAVSTTW"
     aSDomain        1767..2648
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS21195_Aminotran_5.1"
                     /evalue="8.40E-30"
                     /label="IE233_RS21195_Aminotran_5.1"
                     /locus_tag="IE233_RS21195"
                     /protein_end="310"
                     /protein_start="16"
                     /score="95.8"
                     /tool="antismash"
                     /translation="AAIERRVAALLATEQDVVIMQGEALLPLEGCIRGAARPGSTALNV
                     VTGPYGQTFGNWLRDCGAEVVDLEVPFHAAVTAEQIDRALTDRPEIDFVSLVHAEAATG
                     NTNPVAEIGEVVRRHGALFMLDAVASVAAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAV
                     SVSARAWERIAANPSAPRRSYLSLLDWKQRWIDGGRKALLHAPAQLEMLALEACVERIE
                     SEGLDAVMARHASAAAATRAGALALGGGLVPYVHEAPDAAPVATTLRTPEGVDASELVA
                     KALAADPSLPLIA"
     misc_feature    2857..2871
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.59"
                     /tool="antismash"
     misc_feature    2920..2929
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.55"
                     /tool="antismash"
     misc_feature    2992..3007
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    3017..3031
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.75"
                     /tool="antismash"
     misc_feature    complement(3028..3042)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.85"
                     /tool="antismash"
     misc_feature    complement(3102..3113)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.18"
                     /tool="antismash"
     gene            3141..3662
                     /db_xref="GeneID:96292265"
                     /gene="ectA"
                     /locus_tag="IE233_RS21200"
                     /old_locus_tag="GCM10010326_43400"
     CDS             3141..3662
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96292265"
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121394.1"
                     /locus_tag="IE233_RS21200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43400"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_161247033.1"
                     /transl_table=11
                     /translation="MTAAQTAVRIESPRVEDGAAIWRIARDSEVLDLNSSYSYLLWCRD
                     FARTSAVARDDDGTPIAFITGYVRPDRPGTLVVWQVAVDHAHRGHGLAGLLLEALTARV
                     SASHGTTCLETTVSPDNTPSDRLFTSFAKRRGAALDRELLFDAGLFPDDGHQPEVLYRI
                     GPLHPQGETL"
     gene            3659..4930
                     /db_xref="GeneID:96292266"
                     /gene="ectB"
                     /locus_tag="IE233_RS21205"
                     /old_locus_tag="GCM10010326_43410"
     CDS             3659..4930
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 6.7e-71.
                     Score: 231.0. Matches aSDomain:
                     nrpspksdomains_IE233_RS21205_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GeneID:96292266"
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835756.1"
                     /locus_tag="IE233_RS21205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43410"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_161247031.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.5e-77, bitscore:
                     254.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFESLESEVRSYCRGWPAVFDRAQGARITDEDGHSY
                     LDFFAGAGSLNYGHNNPVLKRALLDYIERDGITHGLDMATTAKRAFLETFQNVILRPRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYLDGRVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALADLCRRRDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTLSKSISGYGLPMS
                     LCLFKGELDVWEPGEHNGTFRGNNPAFVTATAALEAYWADGGQMEKHTLARGEQIEQAL
                     LALCTEHSRLGASYRGRGLVWGLEFADPARASEVCARAFELGLLLETSGPKSEVVKLLP
                     SLTITHEELDEGLRSLARAVAATV"
     aSDomain        3743..4756
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS21205_Aminotran_3.1"
                     /evalue="6.70E-71"
                     /label="IE233_RS21205_Aminotran_3.1"
                     /locus_tag="IE233_RS21205"
                     /protein_end="366"
                     /protein_start="28"
                     /score="231.0"
                     /tool="antismash"
                     /translation="FDRAQGARITDEDGHSYLDFFAGAGSLNYGHNNPVLKRALLDYIE
                     RDGITHGLDMATTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVEAALKLARKVKG
                     RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYLDGRVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALADLCRRRDMLLIVDDIQMGCGR
                     TGAFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKGELDVWEPGEHNGTFRGNNPAFV
                     TATAALEAYWADGGQMEKHTLARGEQIEQALLALCTEHSRLGASYRGRGLVWGLEFA"
     gene            5001..5405
                     /db_xref="GeneID:96292267"
                     /locus_tag="IE233_RS21210"
                     /old_locus_tag="GCM10010326_43420"
     CDS             5001..5405
                     /codon_start=1
                     /db_xref="GeneID:96292267"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358304.1"
                     /locus_tag="IE233_RS21210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43420"
                     /product="ectoine synthase"
                     /protein_id="WP_100574374.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.5e-55, bitscore:
                     181.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIENTDRHVKAASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCTEGEAELTNEETGETHWIEPGTMYLLNGHERHTLRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEPEEG"
     gene            5408..6268
                     /db_xref="GeneID:96292268"
                     /gene="thpD"
                     /locus_tag="IE233_RS21215"
                     /old_locus_tag="GCM10010326_43430"
     CDS             5408..6268
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96292268"
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007498585.1"
                     /locus_tag="IE233_RS21215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43430"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_161247029.1"
                     /sec_met_domain="PhyH (E-value: 4.1e-41, bitscore: 136.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAQDLYPTRGSAEVVTPRQDPVVWGPSAGLESFEQDGFLAIEDL
                     LSDDEVALYRSELERLIADPAVRADERSIIEPQSQSVRSVFEVHRISDIFARLVRDERV
                     VGTARRILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPRMRTVSVSIALTE
                     NHDTNGGLMIMPGSHRDFLGCEGATPKDNYKKSLQMQDAGTPSDEALTKMADRHGIKLF
                     TGRAGSATWFDCNAMHGSGDNITPFPRSNVFIVFNSVENAAEDPFAAPIRRPEFIGARD
                     FTPVR"
     gene            6384..7052
                     /db_xref="GeneID:96292269"
                     /locus_tag="IE233_RS21220"
                     /old_locus_tag="GCM10010326_43440"
     CDS             6384..7052
                     /codon_start=1
                     /db_xref="GeneID:96292269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381835.1"
                     /locus_tag="IE233_RS21220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43440"
                     /product="hypothetical protein"
                     /protein_id="WP_161247027.1"
                     /transl_table=11
                     /translation="MSMVDEPSRTPVTAADVEHAVRLSVTALRAGLAADWSAPAGTLEW
                     DCWETVEHLSDDLFAYAVQIGPAQPPLDGEVPYLWEARRPGGPRNAVHADRAAGPAGLL
                     QTLEASGALLTAMVRTASPEVRAYHGFGVSDPEGFGAMGIVETLLHTHDVAEGLGLAWT
                     PPAGLCDRVLARLFRDVPEDPDRWRVLLWATGRADLAGRTRPDKWRWYGEPLSSGAATP
                     "
     gene            complement(7027..7728)
                     /db_xref="GeneID:96292270"
                     /locus_tag="IE233_RS21225"
                     /old_locus_tag="GCM10010326_43450"
     CDS             complement(7027..7728)
                     /codon_start=1
                     /db_xref="GeneID:96292270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267489.1"
                     /locus_tag="IE233_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43450"
                     /product="hypothetical protein"
                     /protein_id="WP_161247041.1"
                     /transl_table=11
                     /translation="MESDTTGQAREAARNNADWCAALCRAHGITGREGPYAWTSPRRTP
                     LYYPDAVTLTPEASPGDVLGSIDLTVPGASVKDSFAVLDLSDDGFEVLFEAQWIHRAAP
                     DPTGKGWQLVDGEGELAAWERAWSDGGSEGLFPPALLAEPGHSFLVERDERGEATAGAV
                     AGRSGDVVGISNLYAVDGDQDAAWAGCLATVARLWPGREVVGYESGDDLAAALRAGFAP
                     AGPLRVWLRPN"
     gene            complement(7778..8869)
                     /db_xref="GeneID:96292271"
                     /locus_tag="IE233_RS21230"
                     /old_locus_tag="GCM10010326_43460"
     CDS             complement(7778..8869)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96292271"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006349979.1"
                     /locus_tag="IE233_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43460"
                     /product="alkene reductase"
                     /protein_id="WP_190028044.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLAGTPLANRIALAPMTRSRATGPGNSPTASTAEYYA
                     QRASAGLLITEGVQPSPVGQGYPDTPGLHSDEQIAAWRKVTDAVHAKGGRIFAQLMHAG
                     RIGHPDLLPGDLINVGPSAVAADGQVFTHEGPKPFITPQALSEDQILVTIGDFAAAARN
                     AIEAGFDGVELHGANGYLIHQFLAPNSNVRTDGWGGSVEGRIRFAVEVTKAVAAEIGAD
                     RTAIRLSPGNPYNGIVEPEPDPVYTALVAALEPLGLAYLHVLEVAPESRELTLRLRKSF
                     SGVFVLNAATEGPTGPDALTLIEDGTADLISYGALFLANPDLPARLRAGGPFNAPDPST
                     FFGGDDRGYTDYPALDAAASLGA"
     gene            8993..9529
                     /db_xref="GeneID:96292272"
                     /locus_tag="IE233_RS21235"
                     /old_locus_tag="GCM10010326_43470"
     CDS             8993..9529
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96292272"
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450490.1"
                     /locus_tag="IE233_RS21235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_43470"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_161247023.1"
                     /transl_table=11
                     /translation="MTSDEPVCTDFPHLPSAARGGPFSHAVSRVARLHRIAAGRQLRSI
                     GLYPGQELLMMHLWDAGAARQSELIKLLELDPSTVTKMLQRLEQAGYVRRSPDPKDRRA
                     ALVEATDDGCVLHERVRQAWTDLEEQTLTGLDAAERAELARLLGKVEANLCRSAGAAAD
                     CEAEPSCPSEAGCGE"
     misc_feature    complement(9596..9610)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.37"
                     /tool="antismash"
ORIGIN
        1 cgagcgccgt gcaggccgcg atcgcggcgg agcgccggcc ggccgggacg ttcgcgggca
       61 ggcggaagtt gttgctgttc aaaatggtgg aacccccaca ggagacatgg cagtccgggc
      121 gcccgccacg gggactcgtg ggactcctgc gaatcgaggg gcgcgccggc gacttgggac
      181 accgaatctt tacgcactga gagtgaactg accgtcacac gccgccagtt caccccaaag
      241 ggtggtttcc gccctcatat tcgattcctc cgcccctgct gcccctcttc gtcacccccg
      301 cctccggccc gcaccccgta cgccgcccgc tcgccccggt gcacacatga agaccttcaa
      361 cgacccgacg cctcccggcg tcacgcccgg tcaacccgaa gcgaactccg tgcagtcctc
      421 atgcatcacc ctcggcgcgg gcatcggctc ctcgcccggc ggcgtacacc tgaaatcccg
      481 gcgacggagc ccgagtcgag gcccctcagc ccgcccctca gcccacgatc cgcccgttga
      541 gcacgatgcg gctcggcgcg gccaggacgc ggacgtcggc gcgggggtcc tggtcgtaga
      601 cgaccagatc ggccggcgcg ccctcctcaa gcgcggggcg gccgagccag gcgcgggcgc
      661 cccaggccgt cgccgacagg gcgtcgaggg cggggatgcc cgccttgacg agttcggcga
      721 cctcggcggc caccaggccg tgggcgagcg agccgcccgc gtccgtaccg acgaagacgg
      781 gcacccccgc gtcgtaggcc gagcgcaccg tgtcgtagcg gcgctcgtac agccgccgca
      841 tgtgggcggc ccagtcgggg aacttcgcct cgccgccgtc ggccatgtgc gggaacgtgg
      901 cgatgttgac cagcgtcggc acgatcgcca cgccgcgctc ggcgaacagc gggatggtgt
      961 cctcggtcag gccggtggcg tgctcgatgc agtcgatgcc cgcctcgacg aggtcccgca
     1021 gcgagtcctc ggcgaagcag tgcgcggtga cgcgggcgcc gagccggtgg gcctcggcga
     1081 tcgcggcctc cacctcgccg cgcggccagc aggcggccag gtccccggcg tcccggtcga
     1141 tccagtcgcc gaccagcttg acccagccgt ccccgcgccg cgcctcgcgc gcgacgtagg
     1201 cgaccaggtc gccgggctcg atctcgtgcg cgtagttgcg gatgtagcgg cgggtgcggg
     1261 cgatgtgccg gcccgcccgg atgatcttcg gcaggtcctc gcgggcgtcg atccagcggg
     1321 tgtcggaggg cgagcccgcg tcacgcacca gcagcgtccc ggcgtcccgg tcggtcaggg
     1381 cctgcttctc gctcacctcc tcggacaccg gcccgtgctg gtcgaggccc acgtggcagt
     1441 gcgcgtcgac cagtcccggc agcgcccagc cgctgacggt gagcgcctcg cccggcggcc
     1501 gctcgtaggt gatccgcccg tcgaccgccc acagttcgtc ccgtacgtcc tcgggtcccg
     1561 cgaggacgcg ccccttcaca tgcagcaccg tgcgatcgct catggtcagc actgtacgag
     1621 gcgctgggta gtctccatcc ggaggatcgg acacccgacc cgatcccccg cgtgacctcc
     1681 gatacacgac ctccgaaccg accgaagaag gcatcgccgt gacacacccg ctcctggacc
     1741 tggccccgct caccgccgac cacttcgcgg cgatcgagcg acgggtggcc gccctgctcg
     1801 ccaccgagca ggacgtggtg atcatgcagg gcgaggcgct gctgcccctg gagggctgca
     1861 tccggggcgc ggcccgcccc ggctccaccg cgctcaacgt ggtgaccggc ccctacgggc
     1921 agaccttcgg caactggctg cgcgactgcg gggccgaggt cgtcgacctg gaggtgccgt
     1981 tccacgcggc ggtgaccgcg gagcagatcg accgggcgct cacggaccgc ccggagatcg
     2041 atttcgtctc gctcgtgcac gcggaggcgg cgaccggcaa cacgaacccg gtcgcggaga
     2101 tcggcgaggt ggtgcgccgg cacggcgccc tgttcatgct ggacgcggtg gcctcggtgg
     2161 ccgccgagcc gctgctcccg gacgcctggg gcgtggacct gtgcgtgatc ggcgcgcaga
     2221 aggcgatggg cggcccggcc ggcgtctcgg ccgtctcggt cagcgcccgc gcctgggagc
     2281 ggatcgcggc caacccgagc gccccgcgcc gctcctacct ctcgctcctg gactggaagc
     2341 agcgctggat cgacggcggc cgcaaggccc tgctgcacgc gcccgcccag ctggagatgc
     2401 tggccctgga ggcgtgcgtg gaacgcatcg agtccgaggg cctggacgcc gtgatggccc
     2461 ggcacgcctc ggccgccgcg gcgacccgcg cgggcgccct ggcgctgggc ggcggtctcg
     2521 tcccgtacgt gcacgaggct cccgacgccg ccccggtggc cacgaccctg cgcacccccg
     2581 agggcgtgga cgcctccgag ctggtggcca aggcgctcgc cgcggacccc tcgctgccgc
     2641 tgatcgccgg gggcggggcg ctggcctcga ccatggtccg ggtcaaccac tacggcgtcg
     2701 acgccacgcg cggtgtcgtc cagtcctcgc tcgcggcact gggcgcggca ctcggcgagt
     2761 acggcatcgc cgtggacctg gaagccgccc gcaaggccgt ttccaccacc tggtgacact
     2821 ccccccgcgt tcctccggcg cgtaatgcac aactgaattc tgcaaaacat tccacagaag
     2881 ttccacagaa cgggaagctg cttattcacc gcagcttccc gttttcttat gccccgcctt
     2941 tccgggctca aacgcaaagg tttcaacaag gttccgagcc cgtcacaacg gtgtgatcga
     3001 ctccacaacc ctgccctttt gtccggtaat taccggacaa accggctcgc gtgcatgctc
     3061 gcgtgataac acaaagaagc tccgagcaca cccccggacg ggaatgcgat ttcaatttct
     3121 ggtcggtaaa ttccctcggc atgaccgccg cgcaaacagc agtccgaatc gaaagcccac
     3181 gagtggagga cggagccgcg atctggcgca ttgcccgtga ctccgaggtg ctcgacctca
     3241 actcctcgta cagctatctg ctctggtgcc gcgacttcgc caggacctcc gcggtggccc
     3301 gggacgacga cggcacgccc atcgcgttca tcaccggcta cgtacggccc gaccgcccgg
     3361 gcacgctggt ggtctggcag gtcgccgtcg accacgcaca ccgcggccac gggctcgcgg
     3421 ggctgctgct cgaagcgctg acggcgaggg tgtccgcctc gcacgggacg acctgtctcg
     3481 agacgacggt ctcgccggac aacaccccgt ccgaccggct cttcacctcg ttcgccaagc
     3541 gccgcggcgc cgccctcgac cgagaacttc tcttcgacgc gggtcttttc cccgacgacg
     3601 ggcaccagcc cgaagtcctc taccgcatcg gccccctcca cccccaggga gaaacgctgt
     3661 gaccatcacc ccgcccgccc tgagtgtctt cgaatccctc gagtcggagg tgcgcagcta
     3721 ctgccgcggc tggcccgccg tgttcgaccg cgcgcagggt gcccgcatca ccgacgagga
     3781 cggccacagc tatctcgact tcttcgccgg ggccggctca ctcaactacg ggcacaacaa
     3841 cccggtactg aaacgggcgc tgctcgacta catcgagcgg gacggcatca cccacggcct
     3901 cgacatggcg acgaccgcga aacgggcgtt cctggagacg ttccagaacg tgatcctgcg
     3961 cccgcgcgac ctgccgtaca aggtgatgtt cccgggcccg acgggcacca acgccgtcga
     4021 ggccgcgctg aagctggccc gcaaggtgaa gggccgcgag tcgatcgtct ccttcaccaa
     4081 cgccttccac ggcatgtcgc tcggctcgct cgccgtcacc ggcaacgcct tcaagcgggc
     4141 cggggccggc atcccgctgg tgcacggcac cccgatgccg ttcgacaact acctcgacgg
     4201 ccgggtgccc gacttcctgt ggttcgagcg cctccttgag gaccagggct cgggcctcaa
     4261 caagccggcc gccgtgatcg tggagaccgt gcagggcgag ggcggcatca acgtggcccg
     4321 gcccgagtgg ctgcgcgcgc tcgccgacct gtgccgccgc cgcgacatgc tgctcatcgt
     4381 cgacgacatc cagatgggct gcggccgcac cggcgccttc ttctccttcg aggaggcggg
     4441 catcgtgccg gacatcgtca ccctctccaa gtcgatcagc ggctacggac tcccgatgtc
     4501 gctctgcctg ttcaagggcg agctcgacgt gtgggagccc ggcgagcaca acggcacctt
     4561 ccgcggcaac aaccccgcgt tcgtcaccgc gaccgccgcg ctggaggcgt actgggccga
     4621 cggcggccag atggagaagc acaccctggc gcgcggcgag cagatcgagc aggccctgct
     4681 cgcgctgtgc accgagcaca gccggctcgg cgccagctac cgcggccgcg gcctggtgtg
     4741 gggtctggag ttcgccgacc cggcccgcgc ctccgaggtc tgcgcccgcg ccttcgagct
     4801 ggggctgctc ctggagacct ccggtcccaa gagcgaggtg gtcaagctgc ttccgtcgct
     4861 gaccatcacc cacgaggagc tggacgaggg gctgcggtcg ctggcccgcg cggtcgccgc
     4921 gaccgtctga cccgctcgac cggccatcga ccggccgtcg accggcgtac aagagataca
     4981 cagaaaggga gcaagtcacc gtgattgtcc gctcgttcaa ggacatcgag aacaccgacc
     5041 gccatgtgaa ggccgcctcc ggcacctggg agagcaagcg gatcgtcctc gcgaaggaaa
     5101 aggtcggctt ctcgctgcac gagaccgtcc tgtacgcggg caccgagacc tccatgtggt
     5161 acgccaacca catcgaggcg gtcctgtgca ccgagggcga ggccgagctc accaacgagg
     5221 agaccggcga gacccactgg atcgagccgg gcacgatgta tctcctgaac ggtcacgagc
     5281 gccacaccct gcgccccaag accgacttcc gctgtgtctg cgtcttcaac ccgcccgtca
     5341 ccggacggga ggaccacgac gagaacggcg tctacccgct gctgaccgaa cccgaggagg
     5401 gctgaccatg accgcccagg atctctaccc cacccgtggc tcggccgagg tggtcacacc
     5461 ccgccaggac ccggtcgtct ggggtccgtc cgccgggctc gaatcgttcg agcaggacgg
     5521 cttcctcgcg atcgaggacc tgctctcgga cgacgaggtg gcgctctacc gctcggagct
     5581 ggagcggctg atcgccgacc ccgccgtgcg tgccgatgag cggtcgatca tcgaaccgca
     5641 gtcgcagtcc gtgcgttcgg tcttcgaggt gcaccggatc agcgacatct tcgctcgtct
     5701 ggtgcgcgac gagcgggtcg tgggcacggc acgccgcatc ctcggctcgg acgtgtacgt
     5761 ccaccagtcg cggatcaacg tgaagccggg cttcggcgcc tcgggcttct actggcactc
     5821 ggacttcgag acctggcacg ccgaggacgg tctgccgcgg atgcggacgg tctcggtctc
     5881 gatcgcgctg accgagaacc acgacaccaa cggcggcctg atgatcatgc ccggctcgca
     5941 ccgggacttc ctcggctgcg agggcgccac cccgaaggac aactacaaga agtccctcca
     6001 gatgcaggac gcgggcaccc cctccgacga ggcgctcacc aagatggccg accggcacgg
     6061 catcaagctg ttcaccggcc gggcgggctc ggcgacctgg ttcgactgca atgcgatgca
     6121 cggctccggg gacaacatca ccccgttccc gcgcagcaac gtgttcatcg tcttcaacag
     6181 cgtggagaac gcggccgagg accccttcgc ggccccgatc cgccgcccgg agttcattgg
     6241 ggcgcgggac ttcacgccgg tgcggtagcc gcaggactac gcgcaggagc acgcgcgaag
     6301 gcaaaggccc gggggctccc ccactgctcc cgggccaagg accgtaccaa cgtctccaca
     6361 gagatcgttg gtacggtccc tccatgtcca tggtcgatga accttcccga actcccgtca
     6421 ccgccgccga tgtcgagcac gcggtgcggc tgtccgtcac cgcgctgcgc gccgggctcg
     6481 ccgcggactg gagcgcgccg gccggcacgc tggagtggga ctgctgggag accgtcgagc
     6541 acctctcgga cgacctcttc gcctacgccg tgcagatcgg cccggcccag cccccgctgg
     6601 acggcgaggt cccctatctc tgggaggcca ggcggcccgg cggcccgcgc aacgcggtgc
     6661 acgcggaccg tgccgcgggc ccggccgggc tcctgcagac cctggaggcg agcggcgccc
     6721 tgctgaccgc gatggtgcgc accgcctcgc ccgaggtacg ggcgtaccac ggtttcggcg
     6781 tctcggaccc ggaggggttc ggtgcgatgg gcatcgtcga gacgctgctg cacacgcacg
     6841 acgtggccga ggggctcggc ctggcctgga ctccgccggc cggtctgtgc gaccgggtgc
     6901 tggcccggct gttccgggac gtgccggagg acccggaccg ctggcgggtg ctgctgtggg
     6961 ccaccggccg cgcggacctg gcggggcgga cccgcccgga caagtggcgc tggtacggcg
     7021 agccgctcag ttcgggcgca gccacaccct gagcggcccg gccggggcga agcccgcgcg
     7081 cagggcggcg gccaggtcgt cgccgctctc gtagccgacg acctcgcggc ccggccacag
     7141 tcgggcgacg gtggcgaggc agcccgccca ggccgcgtcc tggtcgccgt cgacggcgta
     7201 caggttggag atgcccacga cgtccccgct ccggccggcg acggctcccg cggtcgcctc
     7261 tccccgttcg tcgcgctcca ccaggaagga gtggccgggt tcggcgagca gcgcgggcgg
     7321 gaagagccct tcgctcccgc cgtcggacca cgcccgctcc caggcggcca actcgccctc
     7381 gccgtcgacg agttgccagc ccttgccggt ggggtcgggg gccgcccgat ggatccactg
     7441 cgcctcgaag aggacctcga agccgtcgtc gctcaggtcg aggacggcaa agctgtcctt
     7501 cacggacgcg ccgggtacgg tcaggtcgat ggagccgagg acgtcaccgg gcgaggcctc
     7561 gggggtgagc gtcaccgcgt ccggatagta gagcggggtg cggcgcgggc tggtccaggc
     7621 gtacggcccc tcgcgccccg tgatgccgtg tgcgcggcag agcgcggcgc accagtcggc
     7681 gttgttgcgg gcggcttcgc gcgcctgccc ggtcgtgtcg ctctccatgg tcacggcccg
     7741 atcctgccgt gccgggccgg gccgtgacca gcggatttca ggcgcccagc gaggcggccg
     7801 cgtcgagcgc ggggtagtcg gtgtagccgc ggtcgtcgcc gccgaagaag gtcgacgggt
     7861 cgggggcgtt gaacgggccg cccgcccgca gccgggccgg caggtccggg ttggcgagga
     7921 agagcgcgcc gtaggagatg aggtcggcgg tgccgtcctc gatcagggtg agcgcgtccg
     7981 gcccggtggg cccttcggtg gccgcgttga ggacgaacac gccggagaac gacttgcgca
     8041 gccggagtgt caactcccgg ctctccggcg cgacttcgag aacgtggagg taggcgaggc
     8101 cgagcggctc aagggcggcc acgagcgcgg tgtagaccgg gtcgggctcg ggctccacga
     8161 tgccgttgta cgggttgccg ggcgagaggc ggatggcggt gcgatcggcg ccgatctcgg
     8221 cggccacggc cttggtcacc tcgacggcga accggatgcg gccctcgacc gaaccgcccc
     8281 aaccatcggt gcgcacattg gagttgggcg cgaggaactg atggatgagg taaccgttgg
     8341 cgccgtgcag ctcgacgccg tcgaagccgg cctcgatcgc attgcgcgcg gcggccgcga
     8401 agtcgccgat ggtgaccagg atctggtcct cgctgagcgc ctgcggggtg atgaagggct
     8461 tggggccctc gtgcgtgaag acctgcccgt cggcggccac ggcggacggg cccacgttga
     8521 tcaggtcgcc gggcagcaga tcggggtggc cgatccggcc cgcgtgcatg agctgggcga
     8581 agatccggcc gcccttggcg tgcacggcat cggtgacctt gcgccaggcc gcgatctgct
     8641 cgtcgctgtg cagccccggg gtgtcggggt agccctggcc gaccggggag ggctggacgc
     8701 cctcggtgat gaggagcccg gccgaggcgc gctgggcgta atactcggcg gtcgacgcgg
     8761 tcggcgagtt gcccggcccg gtggcgcggc tgcgggtcat gggcgccagg gcgatgcggt
     8821 tggcgagcgg ggtgccggcc aggtcgatcg gatcgaaagc ggtggtcaca gcggcctcca
     8881 gggagacaag ggagagtatg cggccgatcc cgaaggttta tgtggtcggc caagtatcgg
     8941 tgccgagagc cactgtagcg cattacttgg ccgaccaagg taatcttgtc gcatgacctc
     9001 cgacgagccc gtctgtaccg atttccccca cctgccgagc gcggcccgcg gcggcccgtt
     9061 cagccatgcg gtctcacggg tggcccgtct gcaccgcatc gccgcgggcc gtcagctgcg
     9121 ctccatcggg ctctacccgg ggcaggagct cctgatgatg cacctgtggg acgcgggggc
     9181 ggcccgccag tccgagctga tcaagctgct tgagctcgac ccgtcgacgg tcaccaagat
     9241 gctccagcgc ctggagcagg ccggctatgt ccggcgcagc cccgacccga aggaccggcg
     9301 cgccgcgctg gtcgaggcga ccgacgacgg ctgcgtcctg cacgagcgcg tgcggcaggc
     9361 ctggacggac ctggaggagc agaccctgac gggcctggac gcggccgaac gggccgagct
     9421 ggcaaggctg ttggggaagg tggaggccaa cctgtgccgc tcggcgggcg ccgcggccga
     9481 ctgcgaggcc gaaccgtcct gcccgagcga ggcgggctgc ggagagtgag gcgccccgcg
     9541 gggagcccgg cggctcccgg ggggtgagcc cggccggggc gtcaactccc ccggccggac
     9601 gggaacttcc gcggacgggc gcttcagcgg gcgggcagca gctccaagag gcggtccacg
     9661 tccgcggccg agctgtacag atggaaggcc gcgcgcagat tgcccgcgcg gttggagagt
     9721 tcgacccccg cacggctcag ctcctcctgg tggtgaccga ggcccgggac cgccacgatc
     9781 gccgagccgg gcgcggccac cggcccgtgc ccgagcgggg cgagcccggc gcggaagcgg
     9841 tcggcgagcg ccgtgttgtg cgcgtggatg cgctcgatgc ccacctcctc gacgagggcc
     9901 agcgaatgcc gggccccggt gtacgagaac agcgccgggc tctcgtcgaa ccgccgcgcg
     9961 gagtgcgcga gttcgtcgat ggggccgtaa caggcgtccc aggggtgctc gcccgccacc
    10021 cagcccgcga agatcgggtt caggtcgccg aggtcgtcgg ggacggtcag gaaggcgacc
    10081 ccgcgcgggg cggccagcca tttgaagccg accgtcacgg tgtagtcgta cgccccggcg
    10141 tcgaccgggt accagcccgc cccctgggac acgtcgacca gggtccgggc gccgtgggca
    10201 cgggcggcct cgcggatcgc ggcgaggtcg gcgatgcggc cgtccgcgga ctggaccgcg
    10261 ctcaccgcga ccagggcggt gcccggccgc accgactcgg ccagccgctc caggggcgcg
    10321 gtgcgcacct tcaggtcccg gcgcatgtgg aacgggttca ccacggaact gaagtcggcc
    10381 tcggcgacga ggacttcggc gccct
//
