LOCUS       NZ_BMUU01000005        31323 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence05, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000005
VERSION     NZ_BMUU01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 590952)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 31323
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..31323
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..31323
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..31323
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[7804:11323](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7805..11323
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     gene            266..1504
                     /db_xref="GeneID:96291162"
                     /locus_tag="IE233_RS15635"
                     /old_locus_tag="GCM10010326_31970"
     CDS             266..1504
                     /codon_start=1
                     /db_xref="GeneID:96291162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513468.1"
                     /locus_tag="IE233_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_31970"
                     /product="transposase"
                     /protein_id="WP_308432606.1"
                     /transl_table=11
                     /translation="MKTTAISTVRTEDPANRDAEWRLPSDTTVFDEIVADLSSTLFSSF
                     RRKDQRRKAEQYLQGLLTAPGRKSIRNIAAQVGGSSAEQGLHHFISSSTWDWRPLRAAL
                     ASHLEQIHCSQAWVVRSTHIPKAGEHSVGVDKLFAPQSGRTFRGQRAFGVWSVSERLSA
                     PINWRLFLPHQWVNDHERRDRAEVPEEFGTESLEECAVAAALDTVRLRGGRRRPVLVDL
                     RQGGVAKAMARFASAGLPVLARVDASYPLAVADRALPGYGAGALPARRILEMVKGMRRP
                     VHWLDAETSWTSRTSLAAAVAVTCPAGPGAGHPRQLLLVGEWLDPARPPAQVWLTDMTQ
                     LQVAPLLRLTKLTRRVDRDFSHVGEATGLRDFVGRSFRGWHRHITLASAAHTAVVLARD
                     DYGMARGVVPVSA"
     misc_feature    complement(267..281)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.91"
                     /tool="antismash"
     gene            complement(1465..3432)
                     /db_xref="GeneID:96291163"
                     /locus_tag="IE233_RS15640"
                     /old_locus_tag="GCM10010326_31980"
     CDS             complement(1465..3432)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033720.1"
                     /locus_tag="IE233_RS15640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_31980"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_161251713.1"
                     /transl_table=11
                     /translation="MSAETWGTESSLLTVLELLAQDAPQHRFDELVQRARRAGAAADDV
                     RRLERAVHLVEEVQNARDSRRRRENGLAELVETARELTVPHDLESLLRLVAQRVKRLLN
                     LDMTCVALQDAHQDLYIHTCEGSTTALVIGHPIRDSRGLGQRALMSGAPLWTADYLGDD
                     SIAHSLASDAVVRAEGVRALLAVPLRNGGSSIGVLYATMRTVRHFTPEEISLVDSFAAL
                     ATVAIERADRLDRASNEVSELELDRFRTRTRLVRLQQLSEAHSSTMDLLLSGADLDTVA
                     KAMGDALDGALQLRDTSGHFLAGSAELPDLDEDALAAATLDAHTYRRPVAASGTTWVAP
                     VTAGAEELGTLVLCPATALVGGDEWLLQLTAHAFAIQLLLQRSAAVAEGSVRDDLFNEL
                     LTTGHSGQNELKVQGAGRLGVDLEVPHVLLVVRPEGGEPGRAVAWGSSYAHRVTGLKTV
                     RDGCVVLLVPGRDTSAIARSVADELSPLLGHPVSVGAAGPGRGADEVARMYQEAKRCLD
                     ALTALNRTGSVASMRDLGFLGLLLSDDHDAGLFIETAIGPVLGYDSDRLTHLTGTLEAY
                     IRSGASPTSAAEALHVHPNTVSRRLERITELLGARWQQPDRLLDIQLALRLHRIREVLI
                     RQPGTGTGHADTGTTPRAMP"
     misc_feature    complement(3562..3576)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    complement(3620..3631)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(3666..4556)
                     /db_xref="GeneID:96291164"
                     /locus_tag="IE233_RS15645"
                     /old_locus_tag="GCM10010326_32000"
     CDS             complement(3666..4556)
                     /codon_start=1
                     /db_xref="GeneID:96291164"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="IE233_RS15645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32000"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_161251711.1"
                     /transl_table=11
                     /translation="MDIKVLGPFSVRERGGTITSPWPQATQVLALLAAQAGGIVPTAHL
                     IEELWPGLPPRHAEDLVEGHVRHLRSQMGAPAAPTGRAEVQPTDAALASVPGGYRLDSG
                     DGAHDARAFQRAAGAGYRAMETEDFERAAGRLREALGLWGGKPYAGVRTGPHLRAHAAR
                     LEESWKRALDQWIAAGLQLGRCRELHADLLVLLSDFRPRQPLYEGLWAGLQLGGDPCRL
                     LRNHQRLSRGSRIPMASASVHVCGHPKRSLAGNFAAEPAITGRPAGSHLFAWHSRPTGL
                     PATGIGEWGALSYPS"
     misc_feature    4941..4954
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.29"
                     /tool="antismash"
     misc_feature    4947..4960
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.18"
                     /tool="antismash"
     misc_feature    4948..4962
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.21"
                     /tool="antismash"
     gene            complement(5092..6612)
                     /db_xref="GeneID:96291165"
                     /locus_tag="IE233_RS15650"
                     /old_locus_tag="GCM10010326_32020"
     CDS             complement(5092..6612)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291165"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010035066.1"
                     /locus_tag="IE233_RS15650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32020"
                     /product="MFS transporter"
                     /protein_id="WP_161251709.1"
                     /transl_table=11
                     /translation="MSQQHTPNSPGLRAWLGLLVVLGPVLLVSMDGSILYLAMPRVTQD
                     LTPTADQALWTLDIYGFAVGSLLIAFGNIGDRYGRLKLLMIGATVFGLASAGSAFAPNA
                     ELLIASRALMGVAGATLLPSALAVLSELFSDPRRRGQAIGIFAAAFAAGFAIGPVAGGI
                     LLERFWWGSVFLINLPVIALFLIFAPILLREVSTTRPGRIDRFSVVASAAGLLGVVYGL
                     KNAAAEGISLLPTLVGLGGIVLLALFVRRQRHIEYPLMDFTLFRDRVFTVAIITGLLPL
                     AAWSAAAYLSGVYLQSVLGLPVLEAALLALPGAAVLTTTCVVTPLVVDRIGKRTMLIIC
                     HFSIAAGLLFLLPATTSGGIGWYIASTSIAGLGYGISFSVVADTAVGAVPAERAGSAGA
                     IAETSNEIGNALGIALIGSLAALVFRLQGPDLAPTLDETLNLPGLASSVVGDAKSAFVT
                     GLHVAVAVASLLHVALGLLALRWLPRGATEEKAADSVSEENADLSLRP"
     gene            6716..7582
                     /db_xref="GeneID:96291166"
                     /locus_tag="IE233_RS15655"
                     /old_locus_tag="GCM10010326_32030"
     CDS             6716..7582
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038308.1"
                     /locus_tag="IE233_RS15655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32030"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_167152149.1"
                     /transl_table=11
                     /translation="MESLGTFLKSRRDRVTPDEIGLRTHGTGRRVPGLRREELAQLAGV
                     SAGYYTRLEQGQAETASEQVLDALARALQLDPTETVHLHNLARHSTTPRLGEPPAEEPH
                     QRVLALLDSLGEAAPAIVLGRRGDVLAWNRSGHALFADHIAYDSPSDPERRPSIPRMFF
                     LDPVTRDLYRNWHALARAHVAYLRLTAGRYPTDARLAELIGELTMRSDDFSAMWATRDV
                     ADCTTGTMHIQHPTVGAASVDYQVWLQPDSPDHRLEVYTPNDPGSADALRVLTHQSQSG
                     IGSPVKG"
     misc_feature    complement(6750..6762)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            7805..11323
                     /db_xref="GeneID:96291167"
                     /gene="car"
                     /locus_tag="IE233_RS15660"
                     /old_locus_tag="GCM10010326_32040"
     CDS             7805..11323
                     /EC_number="1.2.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0031177 - phosphopantetheine binding
                     [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: AMP-binding (81-514). E-value: 1.5e-68.
                     Score: 223.2. Matches aSDomain:
                     nrpspksdomains_IE233_RS15660_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (657-724). E-value: 5.3e-13.
                     Score: 41.1. Matches aSDomain:
                     nrpspksdomains_IE233_RS15660_PP-binding.1"
                     /NRPS_PKS="Domain: TD (779-1044). E-value: 1.5e-70. Score:
                     229.1. Matches aSDomain: nrpspksdomains_IE233_RS15660_TD.1"
                     /codon_start=1
                     /db_xref="GeneID:96291167"
                     /gene="car"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041592.1"
                     /locus_tag="IE233_RS15660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32040"
                     /product="carboxylic acid reductase"
                     /protein_id="WP_308432607.1"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-66, bitscore:
                     219.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.5e-11, bitscore:
                     37.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 9.4e-58, bitscore:
                     190.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHARYRHPSFSCARDAVSEGHESPLPATEVIGRYTTRRPTMRLAQ
                     VMEDVMVRHADRPAIGERAKEFVRDPATGRVSYRLLPRYETTSFGELWARVRAVANAWH
                     DDHQLKPGDRVAMLGFASGDYTVVDLACTHLGFVSVPLQTSSPASQQRSIIEETQARLV
                     AASVERLDAAVGLAVESPSVERILVFDFHAEVSDHVDALESARGRLDDAGRAVRVDALP
                     ELLRHGAGLPEAPLFVPGDDDDPLAMLIYTSGSTGTPKGAMYTDRLTSAMWGGAWSKLF
                     SEGQTVTFSYMPMSHVAGHSSLKNTLARGGITYFTAKSDLSTFFEDIALARPTELSLIP
                     RVCELIFQKYQSELDRRTATETADRAAVEDQVKADMRVNLLGGHVAWAGCASAPLSAEL
                     TTFMESLLGIELHIIYGSTEAAAVSVDGEMLSPPVTAHKLVDVPELGYYLTDQPHPRGE
                     LLLKTDALVPGYYNHPELTADLLDEDGYYRTGDIVAETGPGRHAIIDRRKSVLKLSQGE
                     FVATSRLEAIFAYSPLVRQVFVYGNSERSYLLAVVVPSADSLGRFEGRPEDLRQQLNES
                     FLRVAKEEGLNSYEIPREFLIEPEPFSQENGLLSDHRKFLRPRLLERYRERLEELYADI
                     TARESEKLLDVRRGAGERSVLETVQRAVQALLGGSGGEVSPSAHFRDLGGDSLTAVGFA
                     DLLDDVFEVRVPVDMIISAATDLRQLAGHIEAKRETGRNRPGFASVHGKGSTEVRAGDL
                     TLEKFMDARIIAGAQQLAAPAGAPRTVLLTGASGYLGRFLCLEWLEQLASVDGQLICLV
                     RGKDVAAARKRIEDSFADGDGAPAQRFRDLAADHLEVVAGDIAEPQLGLSDRTWNRLSE
                     QVDSIVHAGALVNHVLPYNHLFEANVLGTAELIRLALTGRKKPFTYVSSVAVATSTHPA
                     LGEDPDVRRALPVQPVDEGYAGGYATSKWAGEVLLREAHDLCGLPVTVFRSNMILAHRT
                     YSGQLNVPDMFTRLLFSVLATGVAPSSFYRGDGGEDRPSAHYDGLPVDFTAAAVVTLGG
                     QVSDAYRTFSLVNPHDDGISLDTFIDWLIDAGHRIERIDAYTDWLDRFEAAMRALPEEQ
                     RRHSALPLIHGFKDPETAVRGSVIPSDRFRAAVRAVKVGADADIPQLSPSLIRKYAEDL
                     KSLIAL"
     aSDomain        8048..9346
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS15660_AMP-binding.1"
                     /evalue="1.50E-68"
                     /label="IE233_RS15660_AMP-binding.1"
                     /locus_tag="IE233_RS15660"
                     /protein_end="514"
                     /protein_start="81"
                     /score="223.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="PRYETTSFGELWARVRAVANAWHDDHQLKPGDRVAMLGFASGDYT
                     VVDLACTHLGFVSVPLQTSSPASQQRSIIEETQARLVAASVERLDAAVGLAVESPSVER
                     ILVFDFHAEVSDHVDALESARGRLDDAGRAVRVDALPELLRHGAGLPEAPLFVPGDDDD
                     PLAMLIYTSGSTGTPKGAMYTDRLTSAMWGGAWSKLFSEGQTVTFSYMPMSHVAGHSSL
                     KNTLARGGITYFTAKSDLSTFFEDIALARPTELSLIPRVCELIFQKYQSELDRRTATET
                     ADRAAVEDQVKADMRVNLLGGHVAWAGCASAPLSAELTTFMESLLGIELHIIYGSTEAA
                     AVSVDGEMLSPPVTAHKLVDVPELGYYLTDQPHPRGELLLKTDALVPGYYNHPELTADL
                     LDEDGYYRTGDIVAETGPGRHAIIDRRKSVLKLS"
     aSModule        8048..10936
                     /complete
                     /domains="nrpspksdomains_IE233_RS15660_AMP-binding.1"
                     /domains="nrpspksdomains_IE233_RS15660_PP-binding.1"
                     /domains="nrpspksdomains_IE233_RS15660_TD.1"
                     /final_module
                     /locus_tags="IE233_RS15660"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8543..8596
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS15660_0001"
                     /evalue="3.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="IE233_RS15660"
                     /protein_end="264"
                     /protein_start="246"
                     /score="22.8"
                     /tool="antismash"
                     /translation="AMLIYTSGSTGTPKGAMY"
     CDS_motif       9173..9241
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS15660_0002"
                     /evalue="4.40E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS15660"
                     /protein_end="479"
                     /protein_start="456"
                     /score="15.9"
                     /tool="antismash"
                     /translation="GELLLKTDALVPGYYNHPELTAD"
     aSDomain        9776..9976
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS15660_PP-binding.1"
                     /evalue="5.30E-13"
                     /label="IE233_RS15660_PP-binding.1"
                     /locus_tag="IE233_RS15660"
                     /protein_end="724"
                     /protein_start="657"
                     /score="41.1"
                     /tool="antismash"
                     /translation="TVQRAVQALLGGSGGEVSPSAHFRDLGGDSLTAVGFADLLDDVFE
                     VRVPVDMIISAATDLRQLAGHI"
     CDS_motif       10121..10177
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS15660_0003"
                     /evalue="8.40E+00"
                     /label="NRPS-A_a6"
                     /locus_tag="IE233_RS15660"
                     /protein_end="791"
                     /protein_start="772"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="PAGAPRTVLLTGASGYLGR"
     aSDomain        10142..10936
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS15660_TD.1"
                     /evalue="1.50E-70"
                     /label="IE233_RS15660_TD.1"
                     /locus_tag="IE233_RS15660"
                     /protein_end="1044"
                     /protein_start="779"
                     /score="229.1"
                     /tool="antismash"
                     /translation="VLLTGASGYLGRFLCLEWLEQLASVDGQLICLVRGKDVAAARKRI
                     EDSFADGDGAPAQRFRDLAADHLEVVAGDIAEPQLGLSDRTWNRLSEQVDSIVHAGALV
                     NHVLPYNHLFEANVLGTAELIRLALTGRKKPFTYVSSVAVATSTHPALGEDPDVRRALP
                     VQPVDEGYAGGYATSKWAGEVLLREAHDLCGLPVTVFRSNMILAHRTYSGQLNVPDMFT
                     RLLFSVLATGVAPSSFYRGDGGEDRPSAHYDGLPVDFTAAAVV"
     gene            11320..12165
                     /db_xref="GeneID:96291168"
                     /locus_tag="IE233_RS15665"
                     /old_locus_tag="GCM10010326_32050"
     CDS             11320..12165
                     /NRPS_PKS="Domain: ACPS (137-200). E-value: 1.3e-19. Score:
                     62.4. Matches aSDomain:
                     nrpspksdomains_IE233_RS15665_ACPS.1"
                     /codon_start=1
                     /db_xref="GeneID:96291168"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884646.1"
                     /locus_tag="IE233_RS15665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32050"
                     /product="4'-phosphopantetheinyl transferase"
                     /protein_id="WP_229892611.1"
                     /transl_table=11
                     /translation="MKRFIARPVKEHVRRPAGSPNPAGVMGPEKNSRQAALIEFLLSAP
                     MASAERYEDVPGDTLFPSEHRVISGAGSARRREFATVRACARTALGQLGIPAGPILPGD
                     EGAPRWPRGVVGSMTHCAGYRAAAVARRSDIAAVGIDAEPDAPIPIRVRARVTVAEERT
                     HLAELGVRRPGVSWDRLLFSAKESVFKAWYPWTGRWLEFDQVVVTLSPDDGTFHARLLV
                     PGPRIGGGRLRGFTGGWTRRRNLLLTAVSVAPVIPAPSEQPLSRPSGRARPHAADGEVT
                     "
     aSDomain        11731..11919
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS15665_ACPS.1"
                     /evalue="1.30E-19"
                     /label="IE233_RS15665_ACPS.1"
                     /locus_tag="IE233_RS15665"
                     /protein_end="200"
                     /protein_start="137"
                     /score="62.4"
                     /tool="antismash"
                     /translation="VGIDAEPDAPIPIRVRARVTVAEERTHLAELGVRRPGVSWDRLLF
                     SAKESVFKAWYPWTGRWL"
     gene            12497..13669
                     /db_xref="GeneID:96291169"
                     /locus_tag="IE233_RS15670"
                     /old_locus_tag="GCM10010326_32060"
     CDS             12497..13669
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138900.1"
                     /locus_tag="IE233_RS15670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32060"
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_161251705.1"
                     /transl_table=11
                     /translation="MIDIQSYLRSTPALQQPDWESHPSLEEVRTDLGRMPALVDADAVR
                     RLRALLMEAAAGHLQVIQTGDCAEDPAEATPEDVSRKAALLDVLAGTMKLASGSPVIRV
                     GRIAGQYGKPRSSPTETVDGTQLPVYRGHMVNRPEPDAVRRRPDPRHLLSGYRSASDTM
                     HYLGWRGSASRSELEVPVWTSHEALLLDYELPLLRREPDGSLLLTSTHWPWVGERTRQL
                     DGAHIGLLAAISNPVAVKVGPSMSPDELLALCERLDAQRRPGRLTLIARMGADNAGEKL
                     PLLVKAVAQAGHPVLWLSDPMHGNTVSSPEGLKTRMVRTIVREVENFQAAVGENGGVAA
                     GLHLETTPDTVTECVLDESGLDRLGDKYLSFCDPRLNPRQAIEVVSAWRG"
     gene            13805..14464
                     /db_xref="GeneID:96291170"
                     /locus_tag="IE233_RS15675"
                     /old_locus_tag="GCM10010326_32070"
     CDS             13805..14464
                     /codon_start=1
                     /db_xref="GeneID:96291170"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010270977.1"
                     /locus_tag="IE233_RS15675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32070"
                     /product="isochorismatase family protein"
                     /protein_id="WP_190027356.1"
                     /transl_table=11
                     /translation="MPGIPPIEPYPMPEEGDLPPNTVAWPVDPRRAVLLLHDMQKYFLA
                     PFPPSDAPGNALVNNAALVRARCAELGIPVAYTAQPGGMTTEQRGLLADFWGPGMAPTP
                     EHRQVVEPLQPAPGDWEFTKWRYSAFFKSDLLERMRRHDRDQLIICGVYAHVGVLMTAV
                     EAFTHDIQPILVADAVADFSADDHRLALDYAARRAARVMTAKSVLSELDTATRAAR"
     gene            14491..16401
                     /db_xref="GeneID:96291171"
                     /locus_tag="IE233_RS15680"
                     /old_locus_tag="GCM10010326_32080"
     CDS             14491..16401
                     /codon_start=1
                     /db_xref="GeneID:96291171"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180414.1"
                     /locus_tag="IE233_RS15680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32080"
                     /product="anthranilate synthase family protein"
                     /protein_id="WP_190027357.1"
                     /transl_table=11
                     /translation="MAPQDPLAPQDTAHRLLAGVLDGSAGAFALLHRPESGGPDRLEVM
                     VGDVSQADTLAGLPLSARAGSGAGQELLVLIPYQQITERGFAAHRDGAPLLAMEVREQA
                     TLPLGETMALLPNEPVKMTEGRFDVDDDAYADIVRRVVADEIGTGEGANFVIKRSFTAQ
                     LPGFDTSAALSFFRRLLEREAGAYWTFLIHTGERTFVGATPERHLSVRDGTAVMNPISG
                     TYRYPADGPRLDGVLDFLADTKEADELYMVVDEELKMMARICPTGGRVVGPYLKEMARL
                     AHTEYFIEGQTRGDVREILRETLFAPTVTGSPLESAAKVINRYEPGGRGYYSGVAALIG
                     HDAAGNRTLDSAILIRTADIDIDGRLNIGVGATLVRHSDPVSEVQETRAKAAGLLAALG
                     EPEPTRFGAHPAVLGALGERNGTIGQFWLQDLDSRAGTVEELAGRSVLVIDAEDTFTAM
                     IAHQVRSLGCEVTVRRFDEAYDVDGYDLVVMGPGPGDPRDFGHPKIAHLRTAVAQLLQE
                     RRPFLAVCLSHQVLSTLLGLPLVRRAVPNQGAQHRIDLFGQHERVGFYNTFAATSGADG
                     FEHPVHGPVEVSRDPSTGEVHALRARGFASMQFHAESVLTQNGPRILGRLLTEVARTYV
                     P"
     tRNA            complement(16509..16582)
                     /anticodon=(pos:complement(16546..16548),aa:Pro,seq:ggg)
                     /db_xref="GeneID:96291172"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IE233_RS15685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="GCM10010326_t00380"
                     /product="tRNA-Pro"
     gene            complement(16509..16582)
                     /db_xref="GeneID:96291172"
                     /locus_tag="IE233_RS15685"
                     /old_locus_tag="GCM10010326_t00380"
     gene            16676..17158
                     /db_xref="GeneID:96291173"
                     /locus_tag="IE233_RS15690"
                     /old_locus_tag="GCM10010326_32090"
     CDS             16676..17158
                     /codon_start=1
                     /db_xref="GeneID:96291173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072823.1"
                     /locus_tag="IE233_RS15690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32090"
                     /product="DUF309 domain-containing protein"
                     /protein_id="WP_190027358.1"
                     /transl_table=11
                     /translation="MDGSARDRDAEGRARNARPRDGLGRPLPYGADGVARQPEGVARTP
                     GQTLAEAQRLLDAGMPFHAHEVFEDAWKSGPSREEPLWRGLAQLAVGLTHAARGNARGG
                     ASLLERGTDSLNRYAAGDGVPTYGIDLAGLAAWARELAERLPGPLDAAAEAPRLRG"
     gene            complement(17148..17777)
                     /db_xref="GeneID:96291174"
                     /locus_tag="IE233_RS15695"
                     /old_locus_tag="GCM10010326_32100"
     CDS             complement(17148..17777)
                     /codon_start=1
                     /db_xref="GeneID:96291174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040714.1"
                     /locus_tag="IE233_RS15695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32100"
                     /product="LUD domain-containing protein"
                     /protein_id="WP_190027359.1"
                     /transl_table=11
                     /translation="MNARDRILARVRAAVEGAPEAPPVVRDYLVSHTPDDPAAVLDLLH
                     ENLVDYRARVHRTDEAGIGALVAGLLAARGAGSVLVPRGLPPEWLAEAACAHVQDRVES
                     TAAELDAVTSVVTGCALAIAETGTLVLDGGPAQGRRRITLVPDHHICVVRVPDQIVASV
                     PQAMARLDPGRPLTWISGPSATSDIELDRVEGVHGPRTLDVVLLSP"
     gene            complement(17774..19192)
                     /db_xref="GeneID:96291175"
                     /locus_tag="IE233_RS15700"
                     /old_locus_tag="GCM10010326_32110"
     CDS             complement(17774..19192)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0019516 - lactate oxidation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890741.1"
                     /locus_tag="IE233_RS15700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32110"
                     /product="lactate utilization protein B"
                     /protein_id="WP_190027360.1"
                     /transl_table=11
                     /translation="MSGTFVGMPAFPKAARDAVRDTTLRGNLRHATHTIRDKRAKAVAE
                     LDDWQQLREAGKRIKDLTLRHLDRHLLRLEESVTAAGGTVHWAADAAEANRIVGDLVKA
                     TGETEVVKVKSMATQEIGLNEALAAEGIHAYETDLAELIVQLGDDRPSHILVPAIHRNR
                     AEIRAIFRDRMASWGRPAPEGLTDDPADLAEAARLHLREKFLRAKVGISGANFMVAETG
                     TLVVFESEGNGRMCLTLPETLISVVGIEKTVPTWQDLEVFLQTLPRSSTAERMNPYTSM
                     WTGTADGDGPRTFHLVLLDNGRTDALADDVGRQALRCIRCSACLNVCPVYERAGGHAYG
                     SVYPGPIGAILTPQLRGTASEIDASLPYASSLCGACYEVCPVAIDIPEVLVHLREKVAG
                     QGGPGHRLEKAAMKAATWAMDHPGAMAAGERAASRTRALHPRRPPGAGAWTDSRDLPEL
                     PAEPFRDWWRKNRT"
     gene            complement(19189..19944)
                     /db_xref="GeneID:96291176"
                     /locus_tag="IE233_RS15705"
                     /old_locus_tag="GCM10010326_32120"
     CDS             complement(19189..19944)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291176"
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240777.1"
                     /locus_tag="IE233_RS15705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32120"
                     /product="(Fe-S)-binding protein"
                     /protein_id="WP_190027361.1"
                     /transl_table=11
                     /translation="MRVALFVTCVNDAVYPATGIATVKLLERLGVEVDFPAGQTCCGQP
                     QFNTGYRHETEPLVRRTGRVFEGYDHVVTPSGSCVAMIRDNYPRIGRRAAAEGRGGELA
                     EVARSLVPRVYELTEFLVDVLGVTDVGAYFPHTVTYHPSCHGLRLLGLGDRPRRLLEAV
                     KGLELRELPGAEECCGFGGTFAVKNPDVSAAMGTDKVRNAAATGADVLCGADNSCLMHI
                     GGILHRQDAPLRALHIAEILLSTEAEPHL"
     gene            complement(19968..21197)
                     /db_xref="GeneID:96291177"
                     /locus_tag="IE233_RS15710"
                     /old_locus_tag="GCM10010326_32130"
     CDS             complement(19968..21197)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291177"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656918.1"
                     /locus_tag="IE233_RS15710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32130"
                     /product="cytochrome P450"
                     /protein_id="WP_190027362.1"
                     /sec_met_domain="p450 (E-value: 1.3e-15, bitscore: 52.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRHEHARLDALQRDPYPHYARAREAEGLTFVPELDAWLVARDAD
                     VREVLRRPEAFSSANVLRPDVLPGPTVLAEMGRGFGGRPVVVSSDGAQHQRLRAPIVHG
                     LSPARVAAIVPYAVERATALIDAFAESGSADLMAQFALELPGQVIGRLVGLDPADVPLA
                     VHGGYRAEQLLFRPMDEPGQLAAARDVVAMQHLLDTYVRERHARPQDDLCTSLIGALAA
                     GGESPGAELTLDERHEMVAHLQNFLLAGHLTTSALIGSTVLHLLHHRAQWELLCEKPEL
                     IPSAVEEAARYDSPIQGFRRITTRPVMLSGTELPIGAVVFVAYGSANRDPSRHERPDVF
                     DITRPPARHLAFGYGVHGCPGSSLAREQLRVALELLTARLPGLRLAEDRPVVMRPTMIH
                     RSPEELPVLW"
     gene            complement(21342..22199)
                     /db_xref="GeneID:96291178"
                     /locus_tag="IE233_RS15715"
                     /old_locus_tag="GCM10010326_32140"
     CDS             complement(21342..22199)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446837.1"
                     /locus_tag="IE233_RS15715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32140"
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="WP_190027363.1"
                     /transl_table=11
                     /translation="MPLARTGTLVAEAADKRRAVAAFNIITLEHAEAVIAGAEEAKSPV
                     VLQVSENAVKFRYGRVLPLARAAVAAAEAASVPVALHLDHVKQDELLRQAADAGFSSAM
                     YDAAHLPYEENLAATRAAADWAHTQGLWIEAELGEVGGKDGRAPLDAHAPGARTDPDEA
                     RQFVAESGVDALAVAIGSTHAMTSRTAELDHALLGRLDAALRVPLVLHGSSGVPDDALS
                     AAVAGGIAKVNIGTALNIAMTDAIRSYLAANPEAVDARTYLTVGRQAMAATVTRLIGVL
                     DRTV"
     gene            complement(22252..23133)
                     /db_xref="GeneID:96291179"
                     /locus_tag="IE233_RS15720"
                     /old_locus_tag="GCM10010326_32150"
     CDS             complement(22252..23133)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381453.1"
                     /locus_tag="IE233_RS15720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32150"
                     /product="SIS domain-containing protein"
                     /protein_id="WP_161251688.1"
                     /transl_table=11
                     /translation="MSHVENELSSQPECWKRAAELALQHKDALPAAGERVAVVGCGTSF
                     FMAQAVAALRESAGLGETDAFAASEFPAARRYDRVVALTRSGTTTEVLDLLAQVRGRIR
                     TTAITADPTTPVMEAADDIVVLDFADEESVVQTRFATTAFTLLRAHLGLHTEQAVADAR
                     TALAEPLPEGLVESTQFSFLGRGWTNGLAQEAALKMREASLSWTEAYPAMEYRHGPISI
                     STTSTATWMFGEAPEGLAEQVAATGALWIEGRLDPLAELVRAQRLAVAVAAARGLDPDR
                     PRHLTRSVILDA"
     misc_feature    complement(23173..23186)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.1"
                     /tool="antismash"
     misc_feature    23173..23187
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.57"
                     /tool="antismash"
     misc_feature    complement(23174..23187)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.51"
                     /tool="antismash"
     misc_feature    complement(23176..23189)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    23199..23212
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            23275..24054
                     /db_xref="GeneID:96291180"
                     /locus_tag="IE233_RS15725"
                     /old_locus_tag="GCM10010326_32160"
     CDS             23275..24054
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136987.1"
                     /locus_tag="IE233_RS15725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32160"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_190027364.1"
                     /transl_table=11
                     /translation="MSRDARWQALLELLVEQGRLDVDEAATALGVSAATIRRDFDQLAE
                     QQMLVRTRGGALVHGVSYELPLRYKTARQASEKQRIAKAVADLVAPGEAVGLTGGTTTT
                     EVARALAVRPELAHGSPALTIVTNALNIANELAVRPQFKIVVTGGVARPQSYELTGPLA
                     GGVLNQITMDVAVLGVGAFDVVHGASAHDEDEAGINRLLCERAERVVVAADSTKLGKRT
                     FARICATDQVGTLVTDTAVPDATVAEFTEAGVTVIAV"
     gene            complement(24169..24768)
                     /db_xref="GeneID:96291181"
                     /locus_tag="IE233_RS15730"
                     /old_locus_tag="GCM10010326_32170"
     CDS             complement(24169..24768)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291181"
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240902.1"
                     /locus_tag="IE233_RS15730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32170"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190027365.1"
                     /transl_table=11
                     /translation="MSTQAATAAARRSKISPERELELYDAVLDLLREGGYDSVTMEGVA
                     ARTKCGKATLYRQWKNKPLLVTAALGRNRCSFFSGIDTGSLAGDLREAARAVGRREGPD
                     TALMEAVGQAYIKHPDLREALRETVLNPEIAALDAMIRRGVERGEVAPDNPAIDYVAPM
                     VMGMLRVERLFEDRFHGEDTVLGLIESVVLPALRIG"
     gene            24940..25857
                     /db_xref="GeneID:96291182"
                     /locus_tag="IE233_RS15735"
                     /old_locus_tag="GCM10010326_32180"
     CDS             24940..25857
                     /codon_start=1
                     /db_xref="GeneID:96291182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129026.1"
                     /locus_tag="IE233_RS15735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32180"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_190027366.1"
                     /transl_table=11
                     /translation="MFAGITTGARRQTRPAGPETTAARPPLVRELLLVTALFLVYKFGR
                     QLANGHEARAFDNADRVWSWERALHLPGEGAVQHLLLHGDTLVKAANTFYATVHFPATV
                     AFLVYLYLRRPGHYLWSRRVLAGLTAAALVLHITVPLAPPRMLTTAGLVDTAQVYGPSV
                     YASTPDTDTMANQFAAMPSLHFGWALMVAIGMIMATRSRWRWLWLLHPLLTLLVVVGTA
                     NHYWLDAIVATALLGTVLYFVPAPKRPTQLPAASKRAVRRPSVPQNAPGTPPQSHPAPV
                     PQQAPVPSAVSGRTPAPQLSEAVR"
     gene            25854..26768
                     /db_xref="GeneID:96291183"
                     /locus_tag="IE233_RS15740"
                     /old_locus_tag="GCM10010326_32190"
     CDS             25854..26768
                     /codon_start=1
                     /db_xref="GeneID:96291183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893296.1"
                     /locus_tag="IE233_RS15740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32190"
                     /product="DMT family transporter"
                     /protein_id="WP_161251681.1"
                     /transl_table=11
                     /translation="MNESALLAILLSLASAAGYALAAVGQSRLAAQGGGGMGQLLTRPL
                     WWWAVGLNAAGALMHVAALHYGPLTLVQPLGALTLVAALPLSAYYARRRVTRREWRGAA
                     WTLAGLTGLIAVTGPASPGDALSLSEALAIAAATALLLAFLVRAGAHSARGTGLGHATA
                     SGIASGVASALTQTVTASLSRELPGGPLPWWGTALVAVLVATFAVGGLLLSQAAYRGGL
                     AAPLAVVNLANPAAAAVIGVALLGESFHGGPLGWLTAAASAAVAARGVIMLTGATPADL
                     PTPLPTALPTELPTPEPAVRITA"
     gene            complement(26871..27857)
                     /db_xref="GeneID:96291184"
                     /locus_tag="IE233_RS15745"
                     /old_locus_tag="GCM10010326_32200"
     CDS             complement(26871..27857)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004024 - alcohol dehydrogenase (NAD+)
                     activity, zinc-dependent [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (20-196). E-value: 1.9e-24.
                     Score: 78.3. Matches aSDomain:
                     nrpspksdomains_IE233_RS15745_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GeneID:96291184"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980073.1"
                     /locus_tag="IE233_RS15745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32200"
                     /product="MDR family oxidoreductase"
                     /protein_id="WP_190027367.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.5e-12, bitscore:
                     41.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFRAIRVSKDEQGHRVDTVALEEHDLHEGDVTVAVDYSTVNYKD
                     GLALAHGKGVVRTYPLVPGIDFAGTVESSAHASFAPGDKVVLNGYGVGEEHDGGFAQKA
                     RVSGDWLVPLPAALTTRQAAAIGTAGYTAMLSVLALEDAGLTPDSGDVLVTGAAGGVGS
                     VAVTLLARLGYRVLASTGRPAEADYLRDLGAAEIVDRAELSSPGRPLGKERWAGAVDSV
                     GSHTLVNVLAGTRYGGTVTSCGLAQGPDLPGTVLPFILRGVTLAGIDSVQAPMDRRVRA
                     YERLARDLDLTRLEKMTTLIGLDEVPGVAERILAGQVRGRTVVDVNA"
     aSDomain        complement(27270..27797)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS15745_PKS_ER.1"
                     /evalue="1.90E-24"
                     /label="IE233_RS15745_PKS_ER.1"
                     /locus_tag="IE233_RS15745"
                     /protein_end="196"
                     /protein_start="20"
                     /score="78.3"
                     /tool="antismash"
                     /translation="ALEEHDLHEGDVTVAVDYSTVNYKDGLALAHGKGVVRTYPLVPGI
                     DFAGTVESSAHASFAPGDKVVLNGYGVGEEHDGGFAQKARVSGDWLVPLPAALTTRQAA
                     AIGTAGYTAMLSVLALEDAGLTPDSGDVLVTGAAGGVGSVAVTLLARLGYRVLASTGRP
                     AEADYLRDLGAAE"
     CDS_motif       complement(27354..27404)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS15745_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE233_RS15745"
                     /protein_end="168"
                     /protein_start="151"
                     /score="11.7"
                     /tool="antismash"
                     /translation="VLVTGAAGGVGSVAVTL"
     gene            complement(27988..30180)
                     /db_xref="GeneID:96291185"
                     /locus_tag="IE233_RS15750"
                     /old_locus_tag="GCM10010326_32210"
     CDS             complement(27988..30180)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96291185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103719.1"
                     /locus_tag="IE233_RS15750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_32210"
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="WP_229892675.1"
                     /transl_table=11
                     /translation="MHHNSFTGTAYLPEPTDAGNLTSFGGKGGTYDIAAGTLKARVDFL
                     ADDTMRLRAAPDGTFTDPPGSRMIQSRPEPQRNTNSFDAGAYYGIRSKDVVLRVYKKPL
                     RFALYKGDNRTVIWSEADPLRWTSGGMRQSLTRGVDEQFFGGGEQNGSFSHRDQVMNVG
                     NNTNWNEGGWNNSQPFYISSAGYGVFRNTFTPGAYDFGPRVRTGQQERRLDAYYFTGDV
                     KSVIGKYTSLVGKPFMPPVYGLEPGDSDCYLHNANRGERHTLDALKVADGYTRNQMPLG
                     WMLVNDGYGCGYENLAETGKGLQAHDAQLGLWTQDGLDKLAEQVKAGQRVAKLDVAWVG
                     NGYGFALNACDQAKAGIEDNSDARGFVWLPVSWSGAQRCGVLWSGDQKLSWDYLRWQIP
                     TYAGATLSGIAYNTGDVGSIFGHDPKMYTRDLQWKAFLPAIMTMDGWAKDLTTGKAADQ
                     QPWLDGEPYASINRKYLQLKERLIPYMYGLSKDATKTGVGAVRPLSLEYPDDPNTLGAN
                     AKYEFLAGPDFLVAPVYSDTGVRNGIYLPKGTWTDYWTGRTYQGPTTIDGYAAPLDTLP
                     LFVKGGSIVPMWPKGTTSWQSRDKGELDYDIYPQPGSSSYTLYEDDGVTRQFAKGASAT
                     QRVRVTSAGRASVIDVGAAVGSYQGKPASRAYRFTVHTKAAPGIVALGGTRLQRYGSAA
                     GLAAAGTGWFFDPATGVTEVKTPSRSTAHGFAVEIA"
ORIGIN
        1 agaagttcgg cggtgacagc gtgcccgaga cccgccgcaa cgtcacctcc tacctcgacc
       61 acctccagat ccggtgaccg ggccgggccc ggcggccgcc gtcgggccca tggctgtcgg
      121 gccatgaccg tccgcggggt gcagggggag gtggccgaag cagcgcgtcc ggtccgatta
      181 cggtgatctg cgcacctccc ccgggcaggg cccgcgcagc gatcgtgtgg cagtagcgca
      241 aacggcccga catcgctgga gcattgtgaa gacgactgcc atcagcacag tacgcacgga
      301 ggatccggcc aaccgcgatg cggagtggcg actgccatcg gacaccaccg tgttcgacga
      361 gatcgtcgcc gacctgtcat ccaccctgtt ctcctcgttc cgcaggaagg accagcgccg
      421 caaggccgag cagtacctcc aagggctgct gaccgcgccg gggcgcaagt ccatccgcaa
      481 catcgccgcg caggtcggcg gttcgtcggc ggaacagggg ctgcaccact tcatttcgag
      541 ctccacctgg gactggcgtc ccttgcgcgc ggcgctggcc tcgcatctgg agcagatcca
      601 ctgttcccag gcctgggtgg tgcgttcgac gcacataccc aaggcgggcg agcactcggt
      661 gggcgtggac aagctgttcg cgccgcagtc gggaaggacg ttccgcggcc agcgggcctt
      721 cggtgtgtgg tcggtgagcg agcggctgag cgcaccgatc aactggcggc tcttcctgcc
      781 ccaccagtgg gtgaacgatc acgagcggcg cgaccgggcg gaagtgcccg aggagttcgg
      841 cacggagagc ctggaggagt gtgcggtcgc cgccgcactg gacacggtgc ggttgagggg
      901 cggccggcgc aggcccgtgc tcgtcgatct gcggcagggc ggggtcgcga aggcgatggc
      961 gcggttcgcg tcggccggcc tgccggtgct ggcccgcgtc gatgcctcct acccgctcgc
     1021 cgttgccgac cgggccctgc cgggctacgg cgccggcgct ctcccggccc gccgcatcct
     1081 ggagatggtc aagggcatgc gccgcccggt gcactggctg gacgcggaaa ccagctggac
     1141 gtcgcgtacc tctctggcag ccgcggtcgc ggtcacctgc ccggccggcc cgggtgcggg
     1201 acatccgcgg cagctgctgc tcgtcggcga gtggctcgac cccgcgcggc caccggcgca
     1261 ggtgtggctc accgacatga cgcagcttca ggtcgcaccg ctgctgcgtc tgaccaagct
     1321 gacccggcgg gtcgaccgcg acttctcgca cgtgggcgag gcaacggggc ttcgggactt
     1381 cgtgggccgt tcgttccgcg gatggcaccg gcacatcacc ctcgcgtccg cggcacacac
     1441 cgcggtcgtg ctggcgaggg acgactacgg catggcgcgc ggcgtcgtgc ccgtgtccgc
     1501 gtgaccggtc cccgtgccgg gctgccggat cagcacctcg cggatgcgat ggaggcggag
     1561 cgccagttgg atgtcgagga ggcgatccgg ctgctgccat cgcgcaccga ggagttcggt
     1621 gatgcgctcc aggcgcctcg acacggtgtt ggggtgcacg tgcagtgcct cggcggcact
     1681 ggtcgggctg gcgcccgaac ggatgtaggc ctccagcgtt ccggtgaggt gcgtcagccg
     1741 gtcggagtcg tagccgagga ccggtccgat ggcggtctcg atgaacaggc cggcatcgtg
     1801 gtcgtcggag aggagcaggc ccaagaaccc caggtcccgc atcgaggcga cgcttcccgt
     1861 gcggttcagc gcggtcagcg cgtccaggca gcgcttcgcc tcctgataca tgcgcgcgac
     1921 ttcgtccgcg ccccggcccg gtcctgccgc gccgacggac accggatggc cgagcagggg
     1981 tgacagctcg tcggcgacgg agcgtgcgat cgccgacgtg tcccgcccgg gtacgaggag
     2041 gacgacgcag ccgtcgcgga cggtcttgag accggtcacc cggtgggcgt acgacgagcc
     2101 ccacgccacc gcgcggcccg gctcgccgcc ctcggggcgc accacgagca gaacgtgcgg
     2161 gacctccagg tccacgccca gccggccggc cccctggacc ttgagctcgt tctggccgct
     2221 gtgcccggtg gtcagcagct cgttgaagag gtcgtcgcgc accgatcctt cggccacggc
     2281 cgcactgcgc tggagcagca gctggatggc gaaggcatgg gcggtgagct gcaggagcca
     2341 ttcgtctccc ccgaccagcg cggtggccgg gcacagcacg agtgtgccga gctcctccgc
     2401 tccggccgtc accggagcga cccaggtggt gcccgaggcg gccacgggcc tgcggtaggt
     2461 gtgtgcgtcg agcgtcgcgg ccgccagggc gtcctcgtcc aggtccggca gctctgcact
     2521 gcccgccagg aagtgaccgg aggtgtcgcg cagttgaagc gccccgtcca gcgcgtcacc
     2581 catcgccttc gccacggtgt ccaggtcagc gccggagagc aggaggtcca tggtggagct
     2641 gtgggcctcg ctcagctgct gcagtctgac cagcctggtc cgcgtgcgga accggtccag
     2701 ttcgagttcg ctgacctcgt tgctggcccg gtcgaggcgg tcggcgcgtt cgatggccac
     2761 cgtcgcgagg gcggcgaacg agtcgaccag gctgatctcc tcgggggtga agtgccgcac
     2821 ggtgcgcatc gtcgcgtaga gcacaccgat gctgctgcct ccgttgcgca gggggaccgc
     2881 cagcaaggcg cgcactccct cggcccgcac gacggcgtcg ctcgccaggc tgtgcgcgat
     2941 gctgtcgtca ccgagatagt cggccgtcca cagtggcgcc ccgctcatca gcgctcgctg
     3001 ccccagacct cgactgtccc gaatcgggtg tcctatgacc agcgcggtgg tcgacccctc
     3061 acaggtgtgg atgtacaggt cctggtgggc gtcctgcagg gcgacgcagg tcatgtcgag
     3121 gttgagcagc ctcttgacgc gctgggcgac cagccggagc agcgattcga ggtcgtgcgg
     3181 gacggtcaat tcccgtgctg tctcgacgag ttcggccagg ccgttctcgc gccggcgccg
     3241 cgagtcgcgg gcgttctgga cctcttcgac caggtgcacg gcccgttcga ggcgccgtac
     3301 gtcgtccgcg gccgcacccg cgcgcctcgc ccgctggacg agctcgtcga accggtgctg
     3361 cggtgcgtcc tgggccagga gctcaaggac cgtgagcaga ctcgattccg tgccccatgt
     3421 ttccgctgac acgctgcgcc ccccggcggt cctgtcccct gacgcgcttg aaactagttc
     3481 gtgttcaatt cgccagtcaa ccgtgacctg cgcaaacaag gtccgacggt gccggggtca
     3541 cccatcggag ccgacagctg gtggccgaga accacccgat cctggtggca ggtgccgcgg
     3601 ggcccctcgc agaggcggtg cgttcacctc cgcgaggcgg cccgggtgcg cgggcgtccg
     3661 caccgctacg acgggtacga gagcgctccc cactccccaa tgccggttgc gggcagccca
     3721 gttggacggc tgtgccacgc gaagagatgc gatccggccg gtcggcccgt gatcgccggc
     3781 tcggcggcga agtttcccgc cagggagcgc ttcgggtggc cgcagacatg aacggaggcc
     3841 gacgccatgg gaattcggct cccccggctc agccgctggt ggtttctgag cagtcggcag
     3901 gggtccccac cgagctgcag tcctgcccac aggccttcgt acaggggctg gcggggacgg
     3961 aagtcggaca gcaggaccag gaggtcggcg tggagttcgc ggcaccgtcc cagctgcaac
     4021 ccggcggcga tccactgatc gagggcccgc ttccaggact cctccagacg ggcggcgtgg
     4081 gcccgcagat gcggccctgt gcgcacgccc gcgtacggct tgcctcccca cagccccagc
     4141 gcctcgcgca gccgcccggc ggcgcgctcg aagtcctcgg tctccatggc gcggtagccg
     4201 gctccggcgg cacgctggaa ggcccgcgcg tcgtgcgcac cgtcgccgct gtcgagacgg
     4261 tatccgccgg gcacggaggc caacgccgca tcggtgggct ggacttcggc ccggcccgta
     4321 ggcgcggccg gcgcccccat ctgggagcgc aggtgccgga cgtgaccctc caccaggtcc
     4381 tcggcatggc gtggcggaag gccgggccac agctcctcga tcaggtgggc ggtcggcacg
     4441 atgccgccgg cctgggccgc caacagtgcg agcacctgcg tcgcctgcgg ccagggtgag
     4501 gtgatcgtgc cacctcgttc ccgaacggag aacggaccca gcaccttgat gtccatgaca
     4561 ccccctccgt tccgcgcggc ctagtaccgg cgctcgcgcg ccgtgccacg gatgggttca
     4621 tgtccggaac ggatgccgcg tgtccccgcg cccctccctg tccggcccgg ctggggtaac
     4681 tggcctgcac ggggccgccg ttggcgccat ggcttcaggg gcgcatcggg ggtgccggtg
     4741 ccgacggcca ctgcggtggc cgtcggggac ttacggcgga cgatggctct gctctgcacg
     4801 cccgtactcc ttcgggagag ctgtcgggca cagcacggag cgccctcccg ctgagagaga
     4861 cgttcaggtg tgccgcgtgg tcgagcacca tcccaacagg cctgggcgag ctaggctatg
     4921 acgtaaaaca caggcatagg tttcatcttt attaagcaaa gtgctggcgt ggagctggac
     4981 ttggacctcg gttcttgctg cggcttcggt tgcgggtgaa cagtggggcg gagtgccgtg
     5041 gtgccaccgc ggggcccggc cgtgcggggt cccgcggtgg gcgtcgcgta cctacgggcg
     5101 gagcgagaga tcggcgtttt cctcggacac ggagtccgcg gccttctcct cggtcgcgcc
     5161 cctgggcagc cagcgaagcg ccagcaggcc gagcgcgaca tgcagcaggc tggccacggc
     5221 cacggccacg tgcaggccgg tgacgaaggc cgacttggcg tcgccgacca ccgaggacgc
     5281 gaggccgggc aggttgaggg tctcgtcgag ggtgggcgcg agatcgggcc cctggaggcg
     5341 gaagaccaga gcggcgaggg agccgatgag agcgatgccc agggcgttgc cgatctcgtt
     5401 gctggtctcg gcgatcgcgc ccgccgatcc ggctcgttcg gcgggcaccg cgccgacggc
     5461 ggtgtcggcg acgacgctga aggagatgcc gtagccgaga cccgcgatcg acgtggaggc
     5521 gatgtaccag ccgatcccgc cggaggtggt ggcggggagc aggaacagca gcccggccgc
     5581 gatggagaag tggcagatga tgagcatcgt ccgcttgccg atgcgatcga ccacgagggg
     5641 cgtgacgacg caggtggtgg tgagcaccgc cgccccggga agggccagga gcgccgcctc
     5701 caggaccggg aggccgagga cggactggag gtagacgccc gacaggtacg cggccgccga
     5761 ccaggccgcc agaggcagca ggccggtgat gatcgcgacg gtgaagaccc ggtcgcggaa
     5821 gagggtgaag tccatcaacg ggtactcgat gtgccgctgg cggcgcacga agagggccag
     5881 cagcacgatc ccgcccagac ccacgagggt ggggaggagc gagatgcctt cggcggcggc
     5941 gttcttgaga ccgtagacga cgcccaggag gccggccgcg gaggcaacca cgctgaagcg
     6001 gtcgatgcgg ccggggcggg tcgtactcac ttcacgcagc aggatcggcg cgaagatcag
     6061 gaacagggcg atgacgggca ggttgatcag gaagaccgag ccccaccaga accgttccag
     6121 caggatgccg cccgccaccg ggccgatggc gaaccccgcg gcgaaggcgg cggcgaagat
     6181 cccgatggcc tgtccccgtc gtcgcggatc gctgaacagc tcactcagca cggccagtgc
     6241 ggacggcagg agcgtcgcgc cggccacacc catcagggcg cgggacgcga tgaggagctc
     6301 cgcgttcggc gcgaacgccg accccgcgga ggcgaggccg aagaccgtcg ccccgatcat
     6361 gagcagcttc agacgcccgt accggtcgcc gatgttgccg aacgcgatca gcagggagcc
     6421 gaccgcgaag ccgtagatgt ccagggtcca cagtgcctga tcggcggtcg gtgtgaggtc
     6481 ctgagtgacc cggggcatcg ccaggtacag gatcgatccg tccatggaga ccagcaggac
     6541 gggtcccagt acgaccagca ggcccagcca tgcgcgcaga ccgggtgagt tgggtgtgtg
     6601 ctgttgcgac atgtcctcga ccgtggggca ccgcgccgac gacagccacc cccctgccgt
     6661 gggtagaccc gacaggtata cccagcgccg tgccggttcc gcttacgctc gtgccgtgga
     6721 aagccttgga acgttcttga agagccgccg tgaccgggtc accccggacg agatcgggct
     6781 gcgcactcat gggacggggc gccgtgttcc cgggctgcgg cgggaggagc tcgcccaact
     6841 cgccggagtg agcgccggtt actacacgcg cctggaacag gggcaggccg agaccgcgtc
     6901 cgagcaggtg ctcgacgcac tcgcccgagc gctccagctc gacccgaccg agaccgttca
     6961 cctgcacaac ctcgcccggc actcgaccac gccacggctg ggcgaacccc ccgcggagga
     7021 accccaccag cgcgtgctcg cgcttctcga ttcgctcggt gaggccgcgc cggcgatcgt
     7081 cctgggccgg cgcggggacg tgctcgcatg gaaccgcagc gggcacgccc ttttcgccga
     7141 tcacatcgcc tacgacagcc cgtcggaccc cgaacgccgg ccgtccatcc cgcgcatgtt
     7201 cttcctcgat ccggtgacgc gcgacctgta ccgcaactgg cacgcactcg cccgcgcgca
     7261 cgtcgcctac ctccggctga ccgccgggcg ctatcccacc gatgcgcgcc tggcggagct
     7321 gatcggcgaa ctcaccatgc gcagcgacga cttctcggcc atgtgggcca ctcgggacgt
     7381 cgcggactgc accacgggaa ccatgcacat ccagcacccc accgtgggtg ccgcgagcgt
     7441 cgactaccag gtctggctgc agcccgacag ccccgaccac cgccttgagg tctacacccc
     7501 caacgacccg ggctccgcgg acgccttgcg cgtcctgacc caccagagcc agtccggcat
     7561 cggctctccg gtcaagggct gatcggcggg ttcgccgtcc ggaccttccg cgattcgcgc
     7621 gcacaattcc ctctcgcatt gcgttctcgc attgccttct ccgtggcttc gcggaccgtc
     7681 ggagaataac cgcgcgacgg acctgacata gaagtccgac cgcctggccg accggtgttc
     7741 gagtaggtag cgtcgcctta cgggcaaagg cggtccagga gatctcttga ccctgcggcc
     7801 ggtcatgcat gcccgatatc gacacccctc cttttcgtgc gcacgggatg ccgtctccga
     7861 aggccatgaa tccccgttgc cggcaactga ggtaataggt cgttacacta cgcggaggcc
     7921 aacaatgcga cttgcgcaag tgatggaaga cgtaatggtg cgccatgcgg accggcccgc
     7981 catcggcgaa cgtgcgaagg agttcgtacg ggacccggcg accggccgcg tctcgtaccg
     8041 cctgcttccg cggtacgaga cgaccagttt cggcgagttg tgggcccgcg tgcgcgcggt
     8101 ggccaatgcc tggcacgacg accaccagct gaagccgggc gaccgggtcg ccatgctcgg
     8161 tttcgccagc ggtgactaca ccgtcgtcga tctcgcctgc acacacctcg ggttcgtcag
     8221 cgttccgctc cagaccagtt cgcccgcgtc acagcagcgg tcgatcatcg aagagaccca
     8281 ggcgcgcctg gtcgccgcga gcgtcgaacg ccttgacgcg gcggtcggtc tcgccgtcga
     8341 gagcccctcg gtcgagcgca tcctggtgtt cgacttccat gccgaagtca gcgaccacgt
     8401 cgacgcgctg gagtccgccc gcggccgtct cgacgacgcc ggccgcgccg tgcgtgtcga
     8461 tgccctgccg gagctgctga ggcacggagc cggccttcct gaagcgccct tgttcgtccc
     8521 cggcgacgat gacgacccgc tggcgatgct catctacacc tcggggagca ccggaacgcc
     8581 caagggcgcc atgtacaccg accgcctgac gagtgcgatg tggggcggag cgtggtcgaa
     8641 gctcttctcc gagggccaga cggtcacctt cagctatatg ccgatgagcc acgtggcagg
     8701 ccattcctcg ttgaagaaca ccctggcacg gggcggcatt acgtatttca cggccaagag
     8761 cgatctgtcg acgttcttcg aggacatcgc gctggcccgc ccgacggaac tctcgctgat
     8821 accgcgggtc tgtgagctga tcttccagaa gtatcagagc gaactcgacc ggcggaccgc
     8881 tacggaaacc gccgaccggg cggccgtcga ggatcaggtc aaggcagata tgcgggtgaa
     8941 tctgctgggc ggtcacgtcg cgtgggccgg ctgcgcgtcc gcaccgttgt ccgccgaact
     9001 gaccaccttc atggagtcgc tcctcggcat cgagctgcac atcatctacg gctccaccga
     9061 ggcagcggcg gtatcggtcg acggggagat gctcagcccg ccggtgaccg cccacaagct
     9121 cgtcgacgtt cccgaactcg gctactacct caccgaccag ccgcatccgc gcggagagct
     9181 gctgctcaag accgacgccc tggtacccgg gtactacaac cacccggagc tgacggccga
     9241 cctcctcgac gaggacggct actacaggac aggtgacata gtcgccgaga ccggcccggg
     9301 gcggcacgcc atcatcgacc gccgcaagag cgtgctgaag ctgtcccagg gcgagttcgt
     9361 ggcgacctcc cggctggagg cgatcttcgc ctacagcccc ctggtccgcc aggtgttcgt
     9421 gtacggcaac agtgagcgct cctatctgct ggcggtcgtc gtcccttccg cggactccct
     9481 cgggcgcttc gagggccggc cggaggatct gcggcagcag ctcaacgagt ccttcctgcg
     9541 ggtcgcgaag gaggaggggc tgaactccta cgagatcccc cgtgagttcc tgatcgagcc
     9601 ggagccgttc agccaggaga acggcctgct gtccgaccac cgcaagttcc tgcgtccccg
     9661 tctcctggag cgctaccggg agcgtctgga ggagctgtac gccgacatca ccgcgcgcga
     9721 gagcgagaag ctgctcgacg tccgtcgcgg cgccggcgag cgctccgtac tggagacggt
     9781 ccagcgcgcg gtccaggcgc tgctcggcgg ctcggggggc gaggtgagcc cctcggcgca
     9841 cttcagggat ctgggcggtg attcgctcac cgccgtgggg ttcgccgatc tcctcgatga
     9901 cgtcttcgag gttcgggttc ccgtggacat gatcatcagc gccgccaccg acctccgaca
     9961 gctggccgga cacatcgagg ccaagcgcga gaccggacgg aaccggcccg gcttcgcgtc
    10021 ggtgcacggg aagggaagca ccgaggtccg ggccggggac ctcaccctgg agaagttcat
    10081 ggatgcgcgg atcatcgccg gggcccagca gctcgcggcg cctgccgggg cgcctcggac
    10141 cgtgctgctg accggggcca gcggatatct gggacgcttc ctgtgcctgg agtggctgga
    10201 acaactggca agcgtggacg ggcagttgat ctgtctcgtg cgcggcaagg acgtggcggc
    10261 cgccaggaag cgcatcgagg actcgttcgc cgacggtgac ggagctccgg cccaacggtt
    10321 ccgggacctg gccgcggacc acctggaggt cgtggcgggc gacatcgccg aaccccagct
    10381 ggggttgagc gaccgcacct ggaacaggct ctccgaacag gtggactcga tcgtgcacgc
    10441 cggcgcgctc gtcaaccacg tcctgccgta caaccacctc ttcgaagcca acgtgctggg
    10501 taccgccgag ctgatccggc tggcgctcac cgggcggaag aagccgttca cctacgtctc
    10561 cagcgtggct gtcgccacct ccacgcatcc cgctctgggc gaggaccccg acgtacgccg
    10621 ggcccttccc gtccagccgg tggacgaggg ctacgccggc ggctacgcga cgagcaagtg
    10681 ggccggagag gtgctgctcc gcgaagccca cgacctgtgc ggtctgccgg tcaccgtgtt
    10741 ccgctccaac atgatcctcg cccacaggac gtacagcggg cagctcaatg tccccgacat
    10801 gttcacccgg ctcctcttca gcgtgctcgc caccggtgtc gcaccttcgt ccttctaccg
    10861 cggtgacggc ggagaggacc ggccgagcgc gcactacgac ggactgcccg tggacttcac
    10921 cgctgcggcc gtcgtgaccc tgggcggcca agtgtccgac gcctaccgga cgttcagcct
    10981 ggtcaatccg cacgacgacg gaatctcgct cgacaccttc atcgactggc tgattgatgc
    11041 gggccaccgc atcgagcgca tcgacgcata cacggactgg ctcgaccggt tcgaggcggc
    11101 catgcgggcg cttcccgaag aacagcggcg gcactccgcc ctgccgctca tccacggatt
    11161 caaggacccg gaaacggcag tccggggctc cgtcataccg tccgaccgat tccgtgcggc
    11221 cgtccgggcc gtgaaggtag gggccgacgc ggacattcca cagctctcac cctccctcat
    11281 ccgcaaatac gccgaggacc tgaagtcact catcgccctg tgaagcggtt catcgcccgc
    11341 cccgtcaagg aacatgtacg ccgcccggca ggttcaccga atcctgccgg ggtgatgggc
    11401 cccgaaaaga acagtaggca ggcggcgttg atcgaattcc tgctgtccgc gccgatggct
    11461 tccgcggaga gatacgaaga cgtcccgggc gatactctct tcccctccga gcaccgggtg
    11521 atttccgggg ccggcagcgc gcggcgccgc gaattcgcca ccgtccgggc ctgcgctcgc
    11581 acggcgctgg ggcagctcgg cattcccgcg gggccgatcc tgcccggcga cgaaggcgct
    11641 ccccggtggc cccgcggcgt cgtcggatcc atgacccact gtgcgggata ccgtgcggcg
    11701 gccgtggccc ggcggtccga catcgcggcg gtcggcatcg acgccgagcc cgatgcgccg
    11761 atccccatcc gcgtgcgcgc ccgcgtgacc gtggccgaag agcgcactca tctcgccgaa
    11821 ttgggagtgc gccggcccgg ggtcagctgg gatcgattgc tcttcagcgc aaaggagagc
    11881 gtcttcaagg cctggtatcc atggaccggc cggtggctgg aattcgatca ggtggtggtc
    11941 acactctctc cggacgacgg cacgttccac gctcgactgc tcgtacccgg ccccaggatc
    12001 ggcggcggca gactccgcgg attcacgggt ggctggacgc ggcgccgtaa tcttctgctc
    12061 acagccgttt ccgtcgcccc ggtgattccc gctccttcgg aacagcccct ttcccgcccc
    12121 tcaggtcggg cccggccgca cgcagccgat ggtgaagtta cttgacgtac tagcgaagca
    12181 gccattgcac ggctcattcc gtcggccgat agtaagggtc aacggatcag ttcaagcccc
    12241 ggaatgaagc aatgaagcgc cgacgggcac gccctccgaa gagggaatcc gacggcggca
    12301 atcccgtggc gttccccgga atcacccgta ctccccggaa tttgcccgta ctccccctga
    12361 agcccgtccg cgcgcctcgc gcatggcgaa cgcacaccgg cccgctccac tccccggagc
    12421 gaaatccgtg tccccctgcg attgaccacg tccgctcctg cccggactcg ctccggcatg
    12481 ctcgatgagg gaatcgatga tcgacattca gtcatacctg cggtccacac ccgcgttgca
    12541 gcagcccgac tgggagagcc acccgtcgct ggaagaggtc cgtacggacc tcgggcggat
    12601 gccggccctc gtggacgccg atgccgtgcg ccgcctgcga gcgctgctga tggaagcggc
    12661 cgccgggcac ctgcaggtga ttcagaccgg ggactgcgcc gaggaccccg ccgaggccac
    12721 acccgaggac gtcagccgca aggccgcgct gctggacgtg ctggccggca cgatgaagct
    12781 cgcctcgggc agccccgtca tcagggtggg caggatcgcc gggcagtacg gcaagccccg
    12841 ctcctccccc accgagaccg tcgacggcac ccaactgccc gtctatcgcg gccacatggt
    12901 caaccggccg gagccggatg ccgtgcggcg ccgtcccgac ccgcgtcacc tgctgagcgg
    12961 ataccggtcc gcgagcgaca ccatgcacta cctcggctgg cgcggctccg cgagccggtc
    13021 cgagctggag gtgccggtgt ggaccagcca cgaggccctg ctcctcgact acgagttgcc
    13081 cctgctgcgc cgtgagccgg acggctcgct cctgctgacg tccacgcact ggccgtgggt
    13141 gggtgagcgc accagacaac tggacggcgc ccacatcggg ctcctcgccg cgatctccaa
    13201 cccggtcgcg gtcaaggtcg gcccgtccat gagccccgac gaactcctcg ccctgtgcga
    13261 gcgcctggac gcccagcggc gtcccgggag gctgacgctg atcgcgcgca tgggtgccga
    13321 caacgccgga gagaaactgc ccttgctggt caaggcagtt gcccaggccg gccacccggt
    13381 gctgtggctg tcggacccga tgcacggcaa cacggtctcc agtcccgagg ggctcaagac
    13441 ccgtatggtg cggacgatcg tccgcgaggt cgagaacttc caggccgcgg tgggcgagaa
    13501 cggcggcgtc gcggcgggcc tgcacctgga gacgaccccg gacacggtca ccgaatgcgt
    13561 tctggacgag tccggcctcg accgcctggg cgacaagtac ctcagcttct gcgacccccg
    13621 tctcaacccg cggcaggcca tcgaggtcgt ctccgcgtgg cggggatgag cccacccggt
    13681 cgagccgaag gaaagcctcc gccgccgatg cgtgggtgcc gtaccgcccg cgtcgtcgcc
    13741 cgccatccga ccgtggacga cggtgccgcg ctcggtgtcc cgtcacgaaa ggaccgacag
    13801 gcccatgcct ggcattcccc ccattgagcc gtacccgatg cccgaggagg gcgacctccc
    13861 gcccaacacc gttgcctggc cggtggatcc gcgccgggcg gtgctgctcc tgcacgacat
    13921 gcagaagtac ttcctcgctc cgttcccgcc gtccgacgcg ccggggaacg ccctggtgaa
    13981 caacgccgcg ctggtgcggg cgcgatgcgc cgaactcggc atcccggtgg cctacaccgc
    14041 tcagcccggc ggtatgacca ccgaacagcg cggcctgctc gccgacttct ggggtccggg
    14101 catggctccc acccccgagc accggcaggt cgtggagccc ctccaaccgg cgcctggcga
    14161 ctgggagttc acgaagtggc gctacagcgc cttcttcaag tccgacctcc tggagcggat
    14221 gcgccgccac gaccgcgacc agctcatcat ctgcggggtg tacgcccatg tcggcgtgct
    14281 gatgaccgcc gtcgaggcgt tcacccacga catccagccc atcctggtcg ccgacgcggt
    14341 ggccgacttc tccgcggacg accaccgcct ggcgctcgac tacgcggccc ggcgagccgc
    14401 ccgcgtcatg acggccaagt ccgtgctgag cgaactcgac accgcgacgc gggcagcacg
    14461 gtgagcgcga cccgggcgaa aggaaggccc atggcaccac aggaccccct ggcaccacag
    14521 gacacggcac accgactcct cgcgggcgtc ctcgacggat ccgcgggggc gttcgcgctg
    14581 ctgcaccgcc ccgagtccgg cggcccggac cgcctggagg tgatggtcgg cgacgtctcg
    14641 caggccgaca cactcgccgg gctccccctg tccgcccggg ccgggtccgg agccggtcag
    14701 gaactcctgg tcctcatccc ctaccagcag atcaccgagc gtggcttcgc cgcccaccgc
    14761 gacggcgctc cgctgctcgc gatggaggtg cgcgagcagg ccaccctccc gctcggcgag
    14821 acaatggcgc tgctgccgaa cgaaccggtc aagatgaccg agggccgttt cgacgtggac
    14881 gacgacgcct acgcggacat cgtgcgccgc gtggtcgcgg acgagatcgg caccggcgag
    14941 ggagccaact tcgtcatcaa gcgttcgttc accgcccagt tgcccggctt cgacacatcc
    15001 gccgcgctgt cgttcttccg ccgcctgctg gagcgcgaag ccggagcgta ctggacgttc
    15061 ctcatccaca ccggggagcg gacgttcgtg ggcgccaccc cggaacggca tctcagcgtc
    15121 cgcgacggca cggcggtgat gaaccccatc agcggcacct accgctatcc ggcggacgga
    15181 ccgcgcctcg acggcgtcct ggacttcctg gccgacacga aggaagccga cgagctctac
    15241 atggtcgtcg acgaagagct gaagatgatg gcgcggatct gccccacggg cggccgggtg
    15301 gtggggccct acctcaagga gatggcccgg ctggcccaca ccgagtactt catcgaggga
    15361 cagacgcggg gcgacgtccg ggagatcctc cgcgagacgc tgttcgcgcc gacggtgacg
    15421 ggctcgccgc tggagagcgc cgccaaggtc atcaaccgct acgagccggg cggccgcggc
    15481 tactacagcg gggtcgcggc gctgatcggc cacgatgccg cgggcaaccg cacactggac
    15541 tccgccatcc tgatccgtac cgccgacatc gacatcgacg gccgcctgaa catcggtgtc
    15601 ggggcgaccc tggtgcggca ctcggacccg gtgtccgaag tccaggagac ccgggccaag
    15661 gcggccgggc tgctcgccgc gctcggtgaa ccggagccca ccaggttcgg cgcacacccg
    15721 gccgtcctcg gcgcgctcgg tgaacgcaac ggcaccatcg ggcagttctg gctccaggac
    15781 ctggacagcc gcgccggcac ggtcgaggaa ctcgccgggc gcagcgtgct ggtgatcgac
    15841 gcggaggaca ccttcaccgc gatgatcgcg catcaggtcc ggtccctcgg ctgcgaggtg
    15901 accgtgcggc gcttcgacga ggcgtacgac gtcgacgggt acgacctggt cgtcatgggc
    15961 ccgggcccgg gcgatccccg ggacttcggc caccccaaga tcgcgcacct gcggaccgcg
    16021 gtggcccagc tcctccagga gcggcggccg ttcctggcgg tgtgcctgag ccatcaggtg
    16081 ctgagcacgc tgctcgggct gcccctggtg cgccgtgcgg ttcccaacca gggcgcccag
    16141 caccggatcg acctgttcgg acagcacgag cgggtgggct tctacaacac cttcgccgcg
    16201 acgtcggggg cggacggctt cgagcatccg gtccacggcc cggtcgaggt gagccgtgac
    16261 ccgtcgaccg gcgaggtgca cgccctcaga gcccgcgggt tcgcgtccat gcagttccac
    16321 gccgagtccg tcctgacgca gaacgggccc cgtatcctcg gccgactgct gacggaggtg
    16381 gcacgcacgt acgtacccta gccgtaccgt cccgcacgac cggggtggta ccccgaccgt
    16441 cccgtaccac gaacgagggc cggtgtcgga tgtctccgat accggccctg atctgcgact
    16501 ccttcgagtc gggacgacag gatttgaacc tgcgacccct tgacccccag tcaagtgcgc
    16561 taccaagctg cgccacgtcc cgatgcccgt ctgacctggg gtttcccccg gccgttcgtg
    16621 catgagaacc ataccgcact ccggcaccgc gacaggaacg ggggacaatc ggcacatgga
    16681 cggttccgca cgtgatcgtg atgccgaggg gcgggcgcgc aacgcgcggc ccagggacgg
    16741 gctcgggcgg ccgctgccct atggcgccga cggggtggcc cgtcagccgg agggcgtggc
    16801 gcgcacgccc gggcagaccc tggccgaggc ccagcggctg ctcgacgccg ggatgccgtt
    16861 ccacgcgcac gaggtcttcg aggacgcgtg gaagtcgggc ccctcgcgcg aggaaccgct
    16921 gtggcggggc ctggctcagc tggcggtggg cctcacacat gccgcgcgcg gcaacgccag
    16981 gggcggagcc tccctgctgg agcgcggcac ggactccctc aaccggtacg cggccgggga
    17041 cggcgtgccc acgtacggga tcgatctggc cgggctcgcg gcctgggcac gggagttggc
    17101 ggaacgcctg ccggggccgc tcgacgcggc ggccgaggcg ccccggctca ggggctgagc
    17161 agcaccacgt ccagggtgcg ggggccgtgc acgccctcga cccggtcgag ttcgatgtca
    17221 ctggtcgccg acgggccgga gatccaggtc agcggccggc cggggtccag ccgcgccatc
    17281 gcctgcggta cggacgcgac gatctggtcg ggcacccgca ccacgcagat gtggtggtcc
    17341 ggcacgagcg tgatccggcg tcgcccctgg gccggtccgc cgtccaggac gagggtgccg
    17401 gtctcggcga tcgcgagggc gcagccggtg accacgctgg tgacggcgtc gagttccgcg
    17461 gcggtcgact ccactctgtc ctgcacgtgt gcgcaggcgg cctccgccag ccactcgggc
    17521 ggcagccccc gcggtacgag gacgctgccg gccccgcgcg cggccaggag tccggcgacg
    17581 agggccccga tgcccgcttc atccgtgcgg tgcacgcggg cacggtagtc gacgaggttc
    17641 tcgtgcagca ggtcgaggac ggccgccggg tcgtcgggcg tgtggctcac gaggtagtcg
    17701 cgcacgaccg gcggggcctc gggtgcaccc tccactgcgg cccggacccg ggccaggatg
    17761 cggtcgcgcg cgttcatgtg cggttcttcc tccaccagtc acggaagggt tctgcgggga
    17821 gttcgggcag gtctcggctg tcggtccagg cgccggcgcc ggggggacgc ctcgggtgca
    17881 gggcgcgggt ccgcgacgcc gcccgctccc ccgcggccat ggcaccgggg tggtccatgg
    17941 cccaggtggc cgccttcatc gcggccttct ccaggcggtg ccccgggccg ccctgaccgg
    18001 ccaccttctc gcggaggtgg accaggacct ccgggatgtc gatggcgacc gggcacacct
    18061 cgtagcaggc gccgcacagc gaggaggcgt acggcagcga cgcgtcgatc tcgcttgcgg
    18121 taccgcggag ttgaggggtg aggatggcgc cgatggggcc cgggtacacc gagccgtagg
    18181 cgtgcccgcc ggcccgttcg tagaccgggc acacgttgag gcaggccgag cagcggatgc
    18241 agcgcagcgc ctggcggccg acgtcgtcgg cgagagcgtc ggtgcggccg ttgtccagca
    18301 ggacgaggtg gaaggtccgg gggccgtcgc cgtcggccgt gccggtccac atgctggtgt
    18361 acgggttcat gcgctcggcg gtcgaggagc gcggcagggt ctggaggaag acttccaggt
    18421 cctgccaggt ggggacggtc ttctcgatgc cgacgacgga gatcagggtc tcgggcaggg
    18481 tcagacacat ccgtccgttg ccctcggact cgaagacgac gagggtgccg gtctcggcga
    18541 ccatgaagtt ggcgccggag atgccgacct tcgcccgcag gaacttctcg cgcaggtgca
    18601 gccgggccgc ctcggcgagg tcggcggggt cgtcggtgag tccttccggt gcgggccggc
    18661 cccaactggc catccggtcg cggaagatgg cgcggatctc ggcgcggttg cggtggatcg
    18721 ccgggaccag gatgtgcgag ggccggtcgt cgcccagctg gacgatcagc tcggcgaggt
    18781 cggtctcgta ggcgtggatg ccctcggccg cgagcgcctc gttgaggccg atctcctgcg
    18841 tggccatcga cttgaccttc accacctcgg tctccccggt ggctttgacc aggtccccca
    18901 cgatgcggtt ggcctccgcc gcgtccgcag cccagtggac cgttcccccg gcagccgtga
    18961 ccgactcctc caaccgcagt agatgacggt ccaggtgacg aagcgtcagg tccttgatgc
    19021 gcttgcccgc ctcgcgcagc tgctgccagt cgtcgagttc ggcgaccgcc ttggcgcgct
    19081 tgtcgcggat ggtgtgggtg gcgtgccgca gattgccgcg cagggtggtg tcccgcacgg
    19141 cgtcgcgcgc cgccttcggg aacgcgggca tgccgacgaa ggtgccgctc acagatgggg
    19201 ctccgcttcc gtgctgagga ggatctcggc gatgtggagg gcccgcaggg gggcgtcctg
    19261 gcggtggagg atgccgccga tgtgcatcag acaggagttg tcggcgccgc acagcacgtc
    19321 ggctccggtg gcggcggcgt tgcgcacctt gtcggtgccc atcgccgcgg agacgtccgg
    19381 gttcttgacg gcgaaggtgc cgccgaagcc gcagcactcc tcggcgccgg gcagttcccg
    19441 cagctccagg cccttgaccg cttcgaggag cctgcgcggc cggtcgccca ggcccagcag
    19501 gcgcagcccg tggcaggagg ggtggtaggt gacggtgtgc ggaaagtacg cgccgacgtc
    19561 ggtcacgccc agcacatcga cgaggaactc cgtcagctcg tacacgcgcg ggaccagcga
    19621 ccgcgcgacc tcggccagtt cgccgccccg cccctcggcg gccgcccgcc ggccgatgcg
    19681 cgggtagttg tcacggatca tcgccacgca ggagccggac ggggtgacga catgatcgta
    19741 gccttcgaag acgcggcccg tccggcgcac cagaggttcg gtctcgtgcc ggtagcccgt
    19801 gttgaactgg ggctgtccgc aacacgtctg gccggccggg aagtcgacct cgacgcccag
    19861 ccgttcgagc agcttgacgg tcgcgatgcc ggtggccggg tacaccgcgt cattgacgca
    19921 ggtgacgaag agtgcgacgc gcatggtcgg aggatatgcc gtggcgccta ccagagcacc
    19981 ggcagttcct cgggcgagcg gtggatcatc gtcgggcgca tgacgacggg tctgtcctcc
    20041 gcgaggcgca gtcccgggag gcgagccgtc aggagttcga gggcgacccg gagctgttcg
    20101 cgggccaggg acgagcccgg gcagccgtgc acgccgtacc cgaaggcgag gtggcgcgcg
    20161 ggcgggcggg tgatgtcgaa gacgtcgggg cgttcatggc ggctcgggtc gcggttggcg
    20221 gagccgtacg ccacgaacac cacggcccct atggggagtt cggtgccgga cagcatgacc
    20281 ggacgggtgg tgatgcggcg gaagccctgg atcgggctgt cgtagcgggc ggcttcctcg
    20341 acggcggacg gtatcaactc gggcttctcg cagagcagtt cccactgcgc ccggtgatgc
    20401 agcaggtgca gcaccgtgga accgatcagg gcgctcgtgg tgaggtgccc ggcgagcagg
    20461 aagttctgca gatgggcgac catctcgtgc cgctcgtcca gggtgagttc ggcacctggt
    20521 gactccccgc ccgccgcgag cgcgccgatc agcgaggtgc acaggtcgtc ctgggggcgg
    20581 gcgtggcgct cccgtacgta ggtgtcgaga aggtgctgca tcgcgacgac gtcgcgcgcg
    20641 gctgccagtt ggccgggctc gtccatcggc cggaacagca gctgctcggc acggtagccg
    20701 ccgtgcacgg cgagcggcac gtcggccggg tcgagcccta cgaggcgtcc gatcacctgg
    20761 ccgggcagtt cgagcgcgaa ctgggccatc aggtcggccg agccgctctc ggcgaaggcg
    20821 tcgatgagcg cggtggcccg ctccaccgcg tacggcacga tcgcggccac gcgggcgggc
    20881 gagaggccgt gcacgatggg ggcgcgcagc cgttggtgct gggcgccgtc ggaactgacc
    20941 acgacggggc ggccgccgaa gccccggccc atctcggcga gcacggtggg cccgggcagc
    21001 acgtcggggc gcagcacgtt ggcggaggag aacgcctcgg gccggcgcag gacttcgcgc
    21061 acatccgcgt cccgggccac cagccaggcg tcgagctccg gcacgaaggt cagcccttcg
    21121 gcctcccggg cccgcgcata gtgcggatag gggtcgcgct gcagcgcgtc gagccgagcg
    21181 tgctcatgcc tgtccacagg cccatcgtct acgacgtccg gccacatcgg aagagcgccg
    21241 gacgggcaga acgtggcgct ttcgccgccg ggcggccgac agggccgcga cgcctccgcc
    21301 gccgggtgcc cgacggggcc ccggcggcgg gttcccacgc ctcagacggt ccggtcgagt
    21361 acgccgatga gccgggtgac ggtcgcggcc atcgcctgac ggccgaccgt cagataggtg
    21421 cgggcgtcga ccgcctcggg gttggcggcg aggtagctgc gaatcgcgtc ggtcatcgcg
    21481 atgttgaggg cggtgccgat gttgaccttg gcgatgccgc cggccacggc cgccgacagg
    21541 gcgtcgtccg gaaccccgga ggagccgtgc aggaccagcg gcacccgcag cgccgcgtcg
    21601 agcctgccca gcagggcgtg gtccagttcg gcggtgcgcg aggtcatggc gtgggtgctg
    21661 ccgatggcga cggcgagcgc gtcgacgccc gactcggcga cgaactgccg cgcctcgtcg
    21721 gggtcggtgc gcgcaccggg cgcgtgggcg tcgagcggcg ccctgccgtc cttgccgccg
    21781 acctccccca actcggcctc gatccacagc ccttgggtgt gcgcccaatc ggcggcggcg
    21841 cgcgtcgccg ccaggttctc ctcgtacggc aggtgggccg cgtcgtacat ggcggagctg
    21901 aatccggcgt cggcggcctg gcgcagcagc tcgtcctgct tgacgtggtc gaggtggagc
    21961 gcgaccggta cggaggccgc ctcggcggcg gccaccgccg cccgggccag cggcaggacc
    22021 cggccgtaac ggaacttgac cgcgttctcg ctgacttgga gcacgaccgg cgacttggcc
    22081 tcctcggcgc ccgcgatgac cgcctcggcg tgttccagcg tgatgatgtt gaaggccgcg
    22141 accgcgcggc gtttgtcggc ggcctcggcg acgagtgtgc cggtccgggc gagtggcatc
    22201 agtgcttccc cttcacctgt gtcacgttgt tcggtctctg gtgccggacc ctcaggcgtc
    22261 gaggatcacc gagcgggtga ggtggcgcgg ccggtccggg tccaggccgc gggcggccgc
    22321 gacggcgacg gcgaggcgct gggcgcggac gagttcggcg agcgggtcga ggcggccctc
    22381 gatccacagg gcgccggtgg cggccacctg ctcggcgagc ccttcggggg cctcgccgaa
    22441 catccaggtc gcggtcgagg tggtggagat gctgatgggg ccgtggcggt actccatcgc
    22501 cgggtaggcc tcggtccagg agagcgacgc ctcgcgcatc ttgagggcgg cttcctgggc
    22561 gaggccgttg gtccagccgc ggccgaggaa gctgaactgg gtggattcca cgaggccttc
    22621 gggcagcggc tcggcgagcg cggtgcgcgc gtcggcgacg gcctgctcgg tgtgcagccc
    22681 gaggtgggcc cgcagcagcg tgaaggcggt ggtggcgaag cgggtctgga cgaccgactc
    22741 ctcgtccgcg aagtcgagca ccacgatgtc gtcggcggct tccatcaccg gggtggtggg
    22801 gtcggccgtg atggcggtgg tccggatccg gccgcgcacc tgcgcgagga ggtcgagcac
    22861 ctcggtggtg gtgccggagc gggtgagggc gacgacccgg tcgtagcggc gggcggcggg
    22921 gaactcggag gcggcgaagg cgtcggtctc gccgaggccc gcgctctccc gcagggcggc
    22981 gacggcctgc gccatgaaga aggaggtgcc gcagccgacg acggcgacgc gctcgcccgc
    23041 ggccggcagg gcgtccttgt gctggagggc cagttcggcc gcccgcttcc agcattcggg
    23101 ctgactgctc agttcgttct cgacatggct catgccgggc tcccaccctc tggatgtgac
    23161 gcgctgtcgt gcttgtttct gcaaaatata gctcgatatc gagcacgatc aagcatatgg
    23221 gcgtgcgcta aggtcactac ggacggttac cagtacgaag aacggagggc gcggatgtcg
    23281 cgcgacgccc gctggcaggc gctgctcgaa ctcctcgtgg agcagggccg cctcgatgtc
    23341 gacgaggcgg ccacggccct cggggtgtcg gccgcgacga tccggcgcga cttcgaccag
    23401 ctcgccgaac agcagatgct ggtgcgcacc cggggcggag cactcgtgca cggggtgtcc
    23461 tacgagttgc cgctgcgcta caagaccgcg cgccaggcct cggagaagca gcggatcgcg
    23521 aaggcggtgg cggatctggt ggcgccgggc gaggcggtcg gcctgaccgg cggcaccacg
    23581 acgacggagg tggcccgcgc gcttgccgtg cggcccgaac tggcccatgg atcaccggcg
    23641 ttgacgatcg tgacgaacgc gctcaacatc gcgaacgagc tggcggtgcg gccgcagttc
    23701 aagatcgtgg tgaccggtgg ggtggcccgc ccccagtcct acgagctcac gggccccctc
    23761 gcgggcggcg tcctgaacca gatcacgatg gacgtggcgg tgctcggcgt gggcgcgttc
    23821 gacgtggtgc acggggcctc ggcgcacgac gaggacgagg ccggcatcaa ccggcttctg
    23881 tgcgagcggg ccgagcgggt cgtggtggcc gccgactcca cgaagctggg caagcgcacc
    23941 ttcgcccgga tctgcgcgac ggaccaggtg ggcacgctgg tgacggacac ggcggtcccg
    24001 gacgcgacgg tcgccgagtt caccgaggcg ggcgtgacgg tcatcgcggt ctgaccgcgc
    24061 ccggcaccct cggcgaccct ccaccggagg gccaactctc gtacagctca ggcgacttgg
    24121 gccgcagccc tcaaagaagc tgttcaccgg ggcgggcccc gggccggctc agccgatccg
    24181 cagggccggc agcacgacgg actcgatcag cccgagcacc gtgtcctcgc cgtggaagcg
    24241 gtcctcgaag agccgctcca cgcgcagcat gcccatgacc atgggggcga cgtagtcgat
    24301 cgccgggttg tccggggcga cctcgccgcg ctccaccccc cgccggatca tcgcgtccag
    24361 ggccgcgatc tcgggattca gcacggtctc gcgcagggct tcgcgcagat ccggatgctt
    24421 gatgtaggcc tgcccgacgg cctccatgag tgccgtgtcg ggcccctcgc gccggcccac
    24481 cgcgcgggcc gcctcgcgca ggtccccggc gagcgaaccg gtgtcgatgc cggagaagaa
    24541 cgagcagcgg ttccggccca gcgccgccgt gacgagcagg ggcttgttct tccactgccg
    24601 gtacagggtg gccttgccgc acttggtgcg cgcggccacg ccctccatcg tcacggagtc
    24661 gtagccgccc tctctgagca ggtcgagcac cgcgtcgtac agctcgagct cgcgctcggg
    24721 gctgatcttg ctgcggcggg cagcggccgt ggcggcctgc gtcgacatcg ttccctccgg
    24781 agaaaaacaa ggggcactcc tgcacgtacg agagtaggct ccgctcaatc gagacgcaaa
    24841 cgtatcgaga cgtttgcgtc tcgatgagtt tcgctctagc cttcctctgt ttgcttgtgt
    24901 tttttcttcg tatcgatcca ggttcaaagg ggccggagca tgtttgccgg tataaccacg
    24961 ggggcgcgtc gtcagacccg ccccgccgga ccggagacga ccgccgcacg gccgcccctg
    25021 gtgcgcgagc tgctgctcgt gaccgcgctc ttcctcgtgt acaagttcgg ccgtcagctg
    25081 gccaacgggc acgaggcgag ggccttcgac aacgccgatc gcgtatggag ctgggagcgc
    25141 gcactgcacc tgcccggcga gggcgcggtc cagcatctgc tgctgcacgg cgacaccctc
    25201 gtgaaggccg ccaacacctt ctacgcgacc gtgcacttcc cggccaccgt ggccttcctg
    25261 gtctacctgt acctgcgccg cccgggtcac tacctgtggt cgcgccgggt cctcgccggc
    25321 ctcaccgccg cggccctggt gctgcacatc acggtcccgc tggccccgcc gcgcatgctc
    25381 accacggccg gactcgtcga caccgcccag gtctacggcc cctccgtgta cgcgtcgacg
    25441 ccggacacgg acacgatggc caaccagttc gcggcgatgc cctcgctgca cttcggctgg
    25501 gcgctgatgg tcgcgatcgg catgatcatg gcgacccgga gccgctggcg gtggctgtgg
    25561 ctgctgcatc cgctgctcac cctgctcgtg gtcgtcggca ccgcgaacca ctactggctg
    25621 gacgcgatcg tggccacggc gctcctcggc acggtgctgt acttcgtgcc cgcgccgaag
    25681 cggcccacac agttgcctgc ggcatccaag cgggcggttc gtcggccgtc cgtgccgcag
    25741 aacgcgcccg ggacgccccc gcagtcgcac ccggcgcccg tgccccagca ggcacccgta
    25801 ccgtccgcag tttccgggcg cacccccgcg ccccagctct ccgaggccgt gcgatgaacg
    25861 aatccgcgct gctcgccatc ctgctctcgc tcgcctcggc cgccggctac gcgctggccg
    25921 ccgtcggcca gtcccggctc gccgcccagg gcggcggcgg catgggccag ttgctcaccc
    25981 ggccgctgtg gtggtgggcc gtcggcctca acgccgccgg tgccctcatg cacgtggccg
    26041 cgctgcacta cggcccgctc accctggtcc agccgctcgg cgccctcacc ctggtcgccg
    26101 cgctgccgct gtccgcgtac tacgcgcggc gccgtgtcac ccggcgcgag tggcgcggcg
    26161 cggcctggac gctggcgggg ctcaccgggc tgatcgcggt caccgggccc gcgagccccg
    26221 gcgacgcgct cagcctgagc gaggcgctcg ccatcgccgc ggccaccgcg ctgctgctcg
    26281 ccttcctggt acgggccggg gcccactcgg cccgcggcac cggcctcggc cacgccaccg
    26341 cgtccggcat cgcctccggt gtggcctccg cgctgaccca gacggtcacc gcctcgctct
    26401 cccgcgaact gcccggcggc ccgctgccct ggtggggcac cgccctggtc gcggtgctcg
    26461 tggcgacgtt cgccgtcggc ggcctcctgc tctcgcaggc ggcctaccgc ggcggcctcg
    26521 ccgccccgct ggccgtggtg aacctcgcca acccggcggc cgccgcggtc atcggagtgg
    26581 ccctgctcgg cgagagcttc cacggcggtc cgctcggctg gctgaccgcc gccgcgtcgg
    26641 cggccgtcgc ggcccgcggc gtgatcatgc tgaccggcgc cacccccgcc gacctcccca
    26701 ccccgctccc cacggccctg cccaccgagc tcccgacccc ggaacctgcg gtacggatca
    26761 cggcctgagc ggcgggcccg ggcaggcacc gtccctcgcc ggcccgcggc ccggacgcgc
    26821 ctcggacgtc cagtgcgacg gcgttcccgg cctcgccggg cgcgagcacg tcaggcgttg
    26881 acgtcgacca cggtccggcc gcgcacctgc cccgcgagga tgcgctcggc gacgcccggc
    26941 acctcgtcca ggccgatgag cgtggtcatc ttctccaggc gcgtcaggtc gaggtcccgg
    27001 gcgaggcgct cgtaggcgcg gactcggcgg tccatcgggg cctgtacgga gtcgatgccg
    27061 gccagggtca ccccgcgcag gatgaacggc aggaccgtgc cgggcaggtc ggggccctgg
    27121 gcgaggccgc agctggtgac cgtgccgccg tagcgggtgc ccgcgaggac gttgaccagg
    27181 gtgtggctgc cgaccgagtc gaccgctccg gcccagcgct ccttgccgag cgggcggccg
    27241 ggtgacgaga gttcggcacg gtcgacgatc tcggccgcgc cgaggtcacg caggtagtcc
    27301 gcctcggcgg gccgccccgt ggaggccagt acccggtacc ccagcctggc gagcagcgtc
    27361 accgcgaccg agccgacacc gcccgcggcc ccggtgacga gcacgtcacc gctgtcgggg
    27421 gtcaggcccg cgtcctcaag cgcgagcacg ctgagcatcg cggtgtagcc ggcggtgccg
    27481 atcgcggcgg cctgccgggt ggtgagcgcg gcgggcagcg ggaccagcca gtcgccgctg
    27541 acccgggcct tctgcgcgaa cccgccgtcg tgctcctccc ccacgccgta cccgttgagc
    27601 accaccttgt cgccgggggc gaacgaggcg tgcgcggacg actcgacggt gcccgcgaag
    27661 tcgatgccgg gcaccagcgg atacgtccgc acgacgccct tgccgtgggc gagcgcgagg
    27721 ccgtccttgt agttgaccgt cgagtagtcc acggcgacgg tcacatcgcc ctcgtggagg
    27781 tcgtgctcct ccagggcgac cgtgtcgacg cggtggccct gctcgtcctt ggacacacgg
    27841 atggcgcgga atgacatcga atccctctcc tgcggtcggg gctgtgcggt cctgcgtcga
    27901 tcttgcccca gcctcccccg cgcgcatgcg gaggggccgc accggacggc tcacggcacg
    27961 gcccccgacc cggtggcggt cctcaggtca cgcgatctcg acggcgaagc cgtgcgcggt
    28021 ggaccgcgac ggcgtcttca cctccgtcac tccggtcgcg ggatcgaaga accagccggt
    28081 gcccgccgcg gccagcccgg ccgcagaacc gtagcgctga agacgcgtgc ccccgagcgc
    28141 gacgatgccc ggggcagcct tggtgtggac ggtgaaccgg tacgcacgag aggcgggctt
    28201 gccctggtaa ctgcccacgg ccgcaccgac gtcgatgacc gaggccctcc cggccgaggt
    28261 gacccgcacc cgctgggtgg cggaggcgcc cttggcgaac tgccgggtga cgccgtcgtc
    28321 ctcgtacagc gtgtaggagg aactgcccgg ctgcggatag atgtcgtagt ccagctcgcc
    28381 cttgtcccgg ctctgccagg acgtggtgcc cttgggccac atcggcacga tggagccgcc
    28441 cttcacgaag aggggcaggg tgtccagcgg agccgcatag ccgtcgatcg tcgtggggcc
    28501 ctggtaggtc ctgccggtcc agtagtcggt ccaggtgccc ttgggcagat agatgccgtt
    28561 gcggacgccg gtgtcgctgt agacgggcgc gaccaggaag tcgggcccgg caaggaactc
    28621 gtacttggcg ttcgcgccaa gggtgttggg gtcgtccggg tactccaggg agagcgggcg
    28681 gaccgcgccg acgccggtct tcgtggcgtc cttggagagc ccgtacatgt acgggatgag
    28741 ccgctccttc agctggaggt acttccggtt gatggaggcg tacggctcgc cgtcgagcca
    28801 gggctgctga tcggcggcct tcccggtggt gaggtccttg gcccagccgt ccatcgtcat
    28861 gatggcgggc aggaacgcct tccactgcag gtcgcgggtg tacatcttcg ggtcgtggcc
    28921 gaagatgctg cccacgtcgc ccgtgttgta cgcgatcccg gagagcgtgg cacccgcgta
    28981 cgtggggatc tgccagcgca gatagtccca gctgagcttc tggtcgccgc tccacaggac
    29041 gccgcagcgc tgggcgccgg accaggagac gggcagccat acgaagccgc gggcgtcgct
    29101 gttgtcctcg atgccggcct tcgcctggtc gcaggcgttc agggcgaagc cgtagccgtt
    29161 gccgacccag gcgacgtcca gtttcgcgac ccgctggccc gccttgacct gctcggcgag
    29221 cttgtcgagg ccgtcctggg tccacagccc cagctgggcg tcgtgggcct ggagtccctt
    29281 gccggtctcg gcgaggttct cgtagccgca gccgtagccg tcgttgacga gcatccagcc
    29341 gagcggcatc tggttccggg tgtacccgtc ggcgaccttc agcgcgtcca gggtgtgccg
    29401 ctcgccccgg ttggcgttgt gcaggtagca gtcggagtcg cccggttcga gcccgtacac
    29461 cggcggcatg aacggcttgc ccaccagcga ggtgtacttg ccgatgacgg acttcacgtc
    29521 accggtgaag tagtaggcgt ccaggcgccg ttcctgctgt ccggtccgca cccgcggccc
    29581 gaagtcgtac gcaccgggcg tgaaggtgtt gcggaagacg ccgtacccgg cggacgagat
    29641 gtagaagggc tgggagttgt tccagccgcc ctcgttccag ttggtgttgt tgccgacgtt
    29701 catgacctgg tcgcggtgcg agaagctgcc gttctgctcc ccgccgccga agaactgctc
    29761 gtcgacgccg cgcgtcaggc tctgccgcat gccgccggag gtccagcgca gcgggtcggc
    29821 ctcggaccag atcacggtcc tgttgtcgcc cttgtagagc gcgaagcgca ggggcttctt
    29881 gtagacgcgc aggacgacgt ccttgctgcg gattccgtaa taggcgcccg cgtcgaagga
    29941 gttggtgttc cgctgcggct cgggccggct ctggatcatg cggctgccgg gcgggtcggt
    30001 gaacgtcccg tccggggcgg cacgcagccg catcgtgtcg tcggcgagga agtccacccg
    30061 agccttgagc gtcccggcgg cgatgtcgta cgtgccgccc ttgccgccga acgaggtgag
    30121 gttcccggca tcggtcggct cgggcaggta ggcggtgccc gtgaacgagt tgtggtgcac
    30181 gtcgtagggg acgacgacca cgtggtacgt ccccgacgcc ttcgggatga cggtggcctc
    30241 ggggtcggcg gtgcccgcgc tggaagcgac ctgcttgccg gcgtcgtcgt agacgtacag
    30301 gtcgaagtcg tcggtggggg tggcccattg gacggagacc ggcacccctc cctccgggtt
    30361 gtcgtcccac tgcccggccg gcggcttcac ggtgaggtcg aagcgggcgc agaccgcacc
    30421 gtccgggtcc tgcgcgggtt gcgggcactt gtcgggcgag tcgacggtgc ccttctcgta
    30481 gaccgggctc tgccaggtca gggacttggt cccgctgtcc agggtgccgc cgggcggcgt
    30541 cccgccctcg gcgtgggcgg ccggaacggc cagggcggtg agggcgagcg ccagcaccga
    30601 gaggacggcg acggcgggcc gtcggggcgg gtgggagcca tgccaggggg tccgcaaggt
    30661 ttcgttctcc gttcgtaccg agcaacagcc gggcgcggcg tgcgcgttca tgcttggaac
    30721 cgaggagttt cgagcatcaa gattcaccgt gaggcgggta catgtcaacg ggtgaggcgt
    30781 gagggggtgg ccaaccccct tgtggtgcgg ggtggttggg gtgtgaacgg tggatatgtg
    30841 cggcgaggcc ggggcgcggc gggcgcggcg gggccgtcgc gcccggcccg gccgagggcc
    30901 ggcgccccct ccgggaccgg gcggaggcaa atcccgcgcg aggctccacg aggccctgcg
    30961 aggtctcttc gagccgggga ggccccgggc ggcccggttc gagggccggc tccacgagag
    31021 gagtccctcg gcgcggccct cgccgtgcgg gcggacacga tcgctcccgc atcgcccccc
    31081 gaggctcggg cgggcgcgac ggccgagcgt cgcgacagcg gggtactccc cgcactcggt
    31141 cgtgcggcgt tcgccgccgc gggccgttac ggcaggacga accagtccat gccgaacgcc
    31201 gccgccaggc ccaccacgag cagccaggag ccgagccggg tgcgcccgtt gcggctcagc
    31261 tcgatcacca cgccgcagag gatgagggcg agcccgtaca caccgaccac cagcacggag
    31321 gag
//
