LOCUS       NZ_BMUU01000003        10519 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence03, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000003
VERSION     NZ_BMUU01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 648684)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 265387
            Orig. end                         :: 275906
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10519
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="3"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10519
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10519
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5519](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5519
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(490..505)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.07"
                     /tool="antismash"
     gene            791..1030
                     /db_xref="GeneID:96290270"
                     /locus_tag="IE233_RS11155"
                     /old_locus_tag="GCM10010326_22950"
     CDS             791..1030
                     /codon_start=1
                     /db_xref="GeneID:96290270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018545032.1"
                     /locus_tag="IE233_RS11155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_22950"
                     /product="chaplin"
                     /protein_id="WP_167159057.1"
                     /transl_table=11
                     /translation="MNRIAKSVVSAGAGAAVVMLGAGMASADAGAQGVAANSPGVLSGN
                     LLQVPVHVPVNACGLTVNVIGLLNPNFGNTCINK"
     misc_feature    1203..1217
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.76"
                     /tool="antismash"
     gene            1227..1466
                     /db_xref="GeneID:96290271"
                     /locus_tag="IE233_RS11160"
                     /old_locus_tag="GCM10010326_22960"
     CDS             1227..1466
                     /codon_start=1
                     /db_xref="GeneID:96290271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="IE233_RS11160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_22960"
                     /product="chaplin"
                     /protein_id="WP_100573938.1"
                     /transl_table=11
                     /translation="MSRTAKALVLSTAAVAAIAGGAGIAAADAGAHGAATNSPGVLSGN
                     MAQVPVHIPVNVCGNTVNVIGLLNPAFGNTCINK"
     gene            1693..2322
                     /db_xref="GeneID:96290272"
                     /locus_tag="IE233_RS11165"
                     /old_locus_tag="GCM10010326_22970"
     CDS             1693..2322
                     /codon_start=1
                     /db_xref="GeneID:96290272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660307.1"
                     /locus_tag="IE233_RS11165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_22970"
                     /product="hypothetical protein"
                     /protein_id="WP_190026972.1"
                     /transl_table=11
                     /translation="MLVRTPRRLVAAALSTVIVAGSAGTAMAADSPPPRTVRAEAPVPG
                     ADALLGQAQQLNGLGGVLTPVTDLLTGVLKGGSAADTAALAGKATSALDALKQAAPAAP
                     VTPPAAAPVTPPAAGPAAVPLGGPEQDAVLAAAKDDAVAAVKKGIDDLVKAVTSVNVGA
                     IVPAATSVVTGLVGLVLTTVTGGGLPVPNLPGLPKAPTDAVPKLPV"
     gene            2578..2886
                     /db_xref="GeneID:96290273"
                     /locus_tag="IE233_RS11170"
                     /old_locus_tag="GCM10010326_22980"
     CDS             2578..2886
                     /codon_start=1
                     /db_xref="GeneID:96290273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115470.1"
                     /locus_tag="IE233_RS11170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_22980"
                     /product="hypothetical protein"
                     /protein_id="WP_229892447.1"
                     /transl_table=11
                     /translation="MMKSMKVAAALAGSLAVVGAAAPAFAAGDLPPMSLNGGLDTIAQN
                     VSSAPNMIDASPVRTNLLDPKSDDSLLHTVGATAHDLNKTNGAPNPGQLLGGMPLGG"
     misc_feature    complement(2978..2993)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.66"
                     /tool="antismash"
     gene            3045..3287
                     /db_xref="GeneID:96290274"
                     /locus_tag="IE233_RS11175"
                     /old_locus_tag="GCM10010326_22990"
     CDS             3045..3287
                     /codon_start=1
                     /db_xref="GeneID:96290274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743016.1"
                     /locus_tag="IE233_RS11175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_22990"
                     /product="chaplin"
                     /protein_id="WP_100574270.1"
                     /transl_table=11
                     /translation="MNTAKKTALALAAAGLATGAASGAAFADAGAQGVAAHSPGVLSGN
                     MAQVPVHVPVNLCGNTVDVIGGLNPAFGNTCVNSD"
     gene            3502..4002
                     /db_xref="GeneID:96290275"
                     /locus_tag="IE233_RS11180"
                     /old_locus_tag="GCM10010326_23000"
     CDS             3502..4002
                     /codon_start=1
                     /db_xref="GeneID:96290275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003505.1"
                     /locus_tag="IE233_RS11180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23000"
                     /product="DUF5949 family protein"
                     /protein_id="WP_161255507.1"
                     /transl_table=11
                     /translation="MTSATSAVQPSRAALLGSLIVIAWSGESPDGSGDVPFLMAYSLGD
                     GAEGPEGAEAAARSLLDEIGMPAGSVVDQSQGGSFPVTLIVQGGQAVLTMPTLNAQCPV
                     PPEWLAAAEARGTVQFMFATRSWPEGVPGVAVSDEQLKAFAGDEDTISTAGHCVLPVRR
                     LRG"
     gene            4042..4692
                     /db_xref="GeneID:96290276"
                     /locus_tag="IE233_RS11185"
                     /old_locus_tag="GCM10010326_23010"
     CDS             4042..4692
                     /codon_start=1
                     /db_xref="GeneID:96290276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827085.1"
                     /locus_tag="IE233_RS11185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23010"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_161255510.1"
                     /transl_table=11
                     /translation="MPLPGTIPQQAPATASSGPPPAATAAFGAGRGFAWLVVLAGAAGL
                     LASWVITLDEFELLRNPDFVPGCSLNPVISCGNIMKSAQASVFGFPNPMLGLVAYGIVG
                     CVGMSLLGGGRFGRWYWRTLNAGALAGVVFVGWLQFESLYRINALCLWCCLAWVATIAL
                     FWGVTGLNIVKGALPAPSWARSLFAEFGWAVPVLHIGVIGMLILTRWWDFWTG"
     gene            5001..5519
                     /db_xref="GeneID:96290277"
                     /locus_tag="IE233_RS11190"
                     /old_locus_tag="GCM10010326_23020"
     CDS             5001..5519
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96290277"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378445.1"
                     /locus_tag="IE233_RS11190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23020"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_190026973.1"
                     /sec_met_domain="melC (E-value: 5.8e-38, bitscore: 125.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDATHFWRISRAGRTRPRGRAHEPAGPASRTAWQPVRRGLLRAA
                     FVSATVAFTAAVLSRIPGATPQGGPAGAPGPEPDAGAAFDEMHAGHRIQGWPLGAGRAE
                     LAVFVDGRQLDVMRRADGSYLSSVDHYVSYPTARAAARAAANELGTARLAAVPVHGSHQ
                     EGAGRGVHA"
     gene            5503..6375
                     /db_xref="GeneID:96290278"
                     /locus_tag="IE233_RS11195"
                     /old_locus_tag="GCM10010326_23030"
     CDS             5503..6375
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96290278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="IE233_RS11195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23030"
                     /product="tyrosinase family protein"
                     /protein_id="WP_190026974.1"
                     /transl_table=11
                     /translation="MVYTRKNQRNLTSAERKAFVNAVLELKRSGVYDEFVRTHIEFYVP
                     DGDDGLRVAHMTPSFLPWHRKFLLEFEQALQKINSRVTVPYWDWTRDRSPASSLWSDDF
                     MGGNGRRGDLQVMTGPFAYAHGNWDLAVEVTEARFLTRDLGRPNDPIALPVAADVDRAL
                     ADPVYDTAPWDSTSGSGLRNRMEGWTTGLSGSARFRMHNRVHRWVSGVMLGAASVNDPV
                     FWLHHAYIDSLWARWQAAHPKSQRYLPATPPPSGDPQHGRVAALHDPMPPWNVAPAALL
                     DHTAIYRYA"
     gene            complement(6481..6750)
                     /db_xref="GeneID:96290279"
                     /locus_tag="IE233_RS11200"
                     /old_locus_tag="GCM10010326_23040"
     CDS             complement(6481..6750)
                     /codon_start=1
                     /db_xref="GeneID:96290279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512958.1"
                     /locus_tag="IE233_RS11200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23040"
                     /product="chaplin"
                     /protein_id="WP_100573945.1"
                     /transl_table=11
                     /translation="MSRIAKTAAVVAGAGAMALAGAGIASADAGAEAVAANSPGVLSGN
                     LLQVPVHVPVNLCGNSVNVIGLLNPAFGNTCVNADSHHEGGYGE"
     misc_feature    6793..6809
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.42"
                     /tool="antismash"
     gene            complement(6886..7137)
                     /db_xref="GeneID:96290280"
                     /locus_tag="IE233_RS11205"
                     /old_locus_tag="GCM10010326_23050"
     CDS             complement(6886..7137)
                     /codon_start=1
                     /db_xref="GeneID:96290280"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS11205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_23050"
                     /product="hypothetical protein"
                     /protein_id="WP_167159071.1"
                     /transl_table=11
                     /translation="MSKFSRFSGPAARAALVAALVSVLGTGYAAHAVDHPAPAPPQLAH
                     AGADSRASLLGALSVGAVVTGTAAVALSRRVSRSRYGK"
     gene            complement(7337..8317)
                     /db_xref="GeneID:96290281"
                     /locus_tag="IE233_RS11210"
                     /old_locus_tag="GCM10010326_23060"
     CDS             complement(7337..8317)
                     /codon_start=1
                     /db_xref="GeneID:96290281"
                     /inference="COORDINATES: protein motif:HMM:NF014237.5"
                     /locus_tag="IE233_RS11210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23060"
                     /product="glycoside hydrolase family 26 protein"
                     /protein_id="WP_373300150.1"
                     /transl_table=11
                     /translation="MHPSGAGPAAWKCALCVLVLLLSALVPLASDSGRPGPAPPPSGNA
                     ASIFTGSDGAGVGRLAAAEKWRGRGPLRVGHTYLPGGTWNDIEGPPGLLAPWARWRDQR
                     TDRVLVLNVPMLDHNEEGVPDARVAALLGQASRGAFDAHFRTLAERLVALRLADTIVVL
                     GWEMNGVTYTHRCGPDPAAWRTYWRRVVTAMRSVTGQRFRFDFAPSRGRDAVPWTACYP
                     GDDWVDVLGMDAYDQPAGMSFAQQVEEPYGLRAQVDFAARHHKPVSYPEWGLFRNGDDP
                     AYVRGMTAWFRRYRPVYQTLTDYCPHGLWECGTNPRAARAYLGAR"
     gene            complement(8356..8589)
                     /db_xref="GeneID:96290282"
                     /locus_tag="IE233_RS11215"
                     /old_locus_tag="GCM10010326_23070"
     CDS             complement(8356..8589)
                     /codon_start=1
                     /db_xref="GeneID:96290282"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS11215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_23070"
                     /product="hypothetical protein"
                     /protein_id="WP_161255522.1"
                     /transl_table=11
                     /translation="MNTHHRLKAATVAASLLLLAAPGIAAADDGVAGQGSVSEFGQPKV
                     LGGRGKIGETLTSGVASLSGALQRGGSPSAGH"
     gene            complement(8639..9919)
                     /db_xref="GeneID:96290283"
                     /locus_tag="IE233_RS11220"
                     /old_locus_tag="GCM10010326_23080"
     CDS             complement(8639..9919)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96290283"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487583.1"
                     /locus_tag="IE233_RS11220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_23080"
                     /product="cytochrome P450"
                     /protein_id="WP_229892449.1"
                     /sec_met_domain="p450 (E-value: 3.8e-18, bitscore: 60.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPRTVPAPRGATGDLADPAFWKQPPTQRLARFAELRQQPRPVF
                     FTERRAGRRRPEQGFYALVRHADVLKASRLPRVFASAPGVTSPEPARWVRAVFGDSMVN
                     LDGADHTRLRRIVQQAFTPRLLAATEVSIRELAVRIVDDMVAERPDEFVSAVASRMSFE
                     VICAMLGVPDAYRRRIARQIDRASEHAGVRRSIGARLLSPGKGLRALARMQLTVARLGR
                     ERRRNPTGDLISALVCADVEGQRLTYRQLGSFFSLLLVAGVETTRNAIAHALSLLTDHP
                     DQLALLRGDFERYADSAVDEIVRHSTPIIQFRRTVTSRYVLSGHTFLPGDKVMLLYASA
                     NRDAGVFTDPDAFDITRDPNPHLGYGGGGPHYCLGAHLARLEIKAVLRELLTRPIAVRT
                     LGEPELGTSNFDHRVRRQPFAFDAPRT"
     gene            complement(9994..10272)
                     /db_xref="GeneID:96295767"
                     /locus_tag="IE233_RS39100"
                     /old_locus_tag="GCM10010326_23090"
     CDS             complement(9994..10272)
                     /codon_start=1
                     /db_xref="GeneID:96295767"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS39100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_23090"
                     /product="hypothetical protein"
                     /protein_id="WP_167159077.1"
                     /transl_table=11
                     /translation="MNVRRYLAAAAAGTALAAVIAPSAHAFDLGGTLSGAARTTSAAGA
                     QIKPAANSVVGDKVGQKVTAVKDGVKAGGEAVKAANDAVKAGHALVG"
ORIGIN
        1 cggtggcccg ctcgccctcg ctgacgcaca cgatccgggc ggtccagcgc accgcggcac
       61 gctcccaacc ccgggagagc agcgcggtga tgccgccgac ggcctcgaac gaccaggcgt
      121 gcggctggaa gacggtgggc accctgccgc gcacggcgag ccgggcggcg accccggcct
      181 tggcgctgtg ggcgtggatc acgtcggggc gcacccgccg tacgaggcgg gccgcccgca
      241 gggtctcccc gaagagcgcg gggccaggtg aacgggtggc ccgccagggg tgcacccggg
      301 cacccagacg cgtcagttcg gtgctcaacg ggcctccctc ggggcatgcc acggtgaccc
      361 ggaatccact gcgcagctgg tcccgcacca agtccgtgac gactcgggct acgcccccct
      421 caacgggctg aaccaggtgc aggacactca actgcccggc ggaccccggc ccctcgggtc
      481 cgccgggggt gttcgctctc gtcggcatgc gcggtcactc cggtcctggc gctcgaaaag
      541 aaagctgaac aaaaatgccg cggggctctc cccgcagtgc ggccgccctc gaattccgca
      601 gggccggcgc tccggccgcc gaagatcccg tatgtggcgc ggcccggcgg tgggcaactg
      661 taaccgtatt tacaacccgg tccggtcatg aatgtggaga cggagtgtcc ccttcgagcg
      721 atcgtgcgta tccccttgac gacacggtcg ttgtatcggt ggccccatct ccacccgaaa
      781 ggaaaaagcg atgaatcgaa ttgcaaagtc tgttgtgtcg gcgggcgcag gtgccgcggt
      841 cgtgatgctc ggtgcgggca tggccagcgc cgacgcgggt gcgcagggcg tcgccgccaa
      901 ctctcccggt gtcctgtcgg gcaacctgct ccaggtcccg gtgcacgtcc cggtcaacgc
      961 ctgcggtctg accgtgaacg tgatcggtct gctgaacccg aacttcggca acacctgcat
     1021 caacaagtaa tccccagggg tgacgccgcc ggaccggcgc cgcggctcgc ggcctcggtc
     1081 cggacgggcc ccctcgccat tttcgcggcc cccaaaaccc tggttcaccc gttaggggca
     1141 aaaccgggcg gccgggttcg cgttgaggtg taggtcgagt gacaaacacc cggtcaatga
     1201 ctttctcaat ctaggagtgc ttctccatgt cgcgtaccgc gaaggccctg gtcctgtcca
     1261 ccgctgccgt tgccgccatc gccggtgggg ccggcatcgc cgccgccgac gccggtgcgc
     1321 acggcgcggc caccaactcc cccggcgtcc tgtccggcaa catggcgcag gtccccgttc
     1381 acatcccggt caacgtctgc ggcaacaccg tgaacgtcat cggtctgctg aaccccgcgt
     1441 tcggcaacac ctgcatcaac aagtagttcc tcgccgaagc cccggtccgc tcctctccag
     1501 ggagcgggcc ggggcttcgt gctgccccgg atggcggtag tccgccgggc tcttccggta
     1561 cggggttgtg ccagctcggc gcggcgtggc ggacaactga tgatcactca ggacgaccat
     1621 ccggttgcga ggggttgggg gcgtgcgcac ggtgaggaga gctcgctcgc cccacccaag
     1681 gagaaccgtt tcatgcttgt acgaacaccg cggcgcctgg tcgcagcggc cctttccacc
     1741 gtgatcgtcg ccgggtccgc cgggaccgcg atggccgccg actcaccgcc gccgcgtacg
     1801 gtccgtgccg aggcgccggt cccgggcgcc gacgccctgc tgggccaggc ccagcagttg
     1861 aacggtctcg gcggcgtcct gacgcccgtg accgacctgc tgaccggcgt gctcaagggc
     1921 ggctcggcgg ccgacaccgc ggcgctggcc ggcaaggcca cgtccgccct cgacgcgctg
     1981 aagcaggcgg ctccggcggc ccccgtcacg cccccggccg ccgcgccggt caccccgccc
     2041 gccgccggtc cggcggccgt gccgctgggc ggccccgagc aggacgccgt gctggcggcc
     2101 gccaaggacg atgccgtcgc cgcggtcaag aagggcatcg acgacctcgt caaggcggtc
     2161 accagtgtca atgtcggggc catcgtcccc gccgcgacct cggtggtcac cggcctcgtc
     2221 gggctcgtcc tgaccaccgt gaccggcggc ggcctgccgg tgcccaacct accggggctg
     2281 cccaaggcgc ccacggacgc ggtgccgaag ctgcccgtct gagccgcacc ccgagagcgc
     2341 cggcccggca cggacgggac cggcgctttc ggctgtccgg gtccatcaac gtccctgccg
     2401 catcccgcaa ttcatgaaat cccatacgcg tatcggggcc ccgcaattgg gtggcggccc
     2461 atgaatccgg aaccgaaggg tttcccgggc gtcggcgggt cgttacccag ggcgaagcag
     2521 cgcaatgcat tcagggacaa gcacggttcg gcgacggaac tcgccgcgga aggattgatg
     2581 atgaagtcga tgaaggttgc cgcggcactc gccggatccc tcgcggtcgt gggtgcggcg
     2641 gcgccggcct tcgcggccgg ggacctcccg cccatgagcc tgaacggcgg cctcgacacg
     2701 atcgcccaga acgtgtcgtc cgctccgaac atgatcgacg cgtcgccggt gcgcaccaac
     2761 ctgctcgacc ccaagtcgga cgactccctg ctccacaccg tgggtgccac cgcgcacgac
     2821 ctgaacaaga ccaatggggc gcccaacccg ggccagctcc tcggcggaat gccgctgggc
     2881 ggttagcagc aacacgaacg ggtccttccg cacggcgaat tgaggggccg ttcggccgcc
     2941 tcgtgcgctg tacgagggaa agacaataaa cccggcgtgt tcgcttccgg cggctcccgg
     3001 ccatttgcct acgctgaggc aacccccgaa tggaaggttc catcatgaac actgccaaga
     3061 agacggctct cgccctcgcc gccgccggtc tcgccacggg tgccgcctcc ggcgccgcct
     3121 tcgccgacgc gggcgcgcag ggtgtggccg cgcactcgcc cggcgtcctg tccggcaaca
     3181 tggcgcaggt cccggtccac gtcccggtga acctctgcgg caacacggtc gacgtcatcg
     3241 gcggtctgaa cccggccttc ggcaacacct gcgtcaactc ggactgatcc agggccggtt
     3301 gagaccggtc ggcttcagtg cgtggtgagc ggcttcgtgg agttggggat cccggagccg
     3361 cttcgccgtg tccggacgcg ccgagtcgcg cacgggtgac cgaagagtcg cacatgggtg
     3421 ccagaagacc ggtgaaggac ctttcatcca gatgggtgac agctgcgaag ggctcgaccc
     3481 ggaatgtcct agagtcccgg catgacttca gccaccagtg ccgtacagcc gtccagggca
     3541 gccctgttgg gctcgctcat cgtcatcgcg tggagcggtg agtcccccga cgggtccggc
     3601 gatgtgccct tcctcatggc gtactccctc ggtgacgggg ccgagggccc cgagggtgcg
     3661 gaggccgcgg cgcggtcgct gctcgacgag atcggcatgc cggccggcag cgtcgtcgac
     3721 cagtcgcagg gcggctcgtt cccggtgacc ctcatcgtcc agggcggcca ggccgtcctc
     3781 accatgccga cgctcaacgc ccagtgcccg gtgccgcccg agtggctggc cgcagccgag
     3841 gcgcggggca ccgtccagtt catgttcgcc acccgctcct ggcccgaggg cgtgcccgga
     3901 gtcgccgtct ccgacgagca gttgaaggcg ttcgcgggcg acgaggacac catctccacc
     3961 gccggccact gcgtgctccc cgtccgccgc ctgcgcggct gaccgcaccc caccgccgga
     4021 cgagaacgga gacgcaaggc catgcccctt cccgggacga tcccgcagca ggctcccgcc
     4081 accgcctcgt ccggcccccc acccgcggcc accgccgcgt tcggcgccgg gcggggcttc
     4141 gcctggctgg tcgtccttgc cggcgcggcg gggctgctcg cgtcgtgggt catcaccctc
     4201 gacgagttcg agctgctgcg gaatcccgac ttcgtccccg ggtgcagcct caacccggtg
     4261 atctcctgcg gcaacatcat gaagagcgcc caggcctccg tcttcggctt ccccaacccg
     4321 atgctcggcc tggtcgcgta cgggatcgtc ggctgcgtgg gcatgagcct gctcgggggc
     4381 ggccggttcg ggcgctggta ctggcgcacg ctcaacgcgg gggcgctggc cggggtcgtc
     4441 ttcgtcggct ggctgcagtt cgagtcgctg taccggatca acgcgctgtg cctgtggtgc
     4501 tgcctggcgt gggtcgccac catcgccctg ttctgggggg tgaccggcct caacatcgtc
     4561 aagggggctc tgcccgcgcc gagttgggcc cgaagcctgt tcgccgagtt cggctgggcg
     4621 gtgccggtgc tgcacatcgg ggtcatcggg atgctgatcc tgacccgctg gtgggacttc
     4681 tggacgggct gagccccgca ggaacgttgg tccgaccgcg tgattggccc gcccccgccg
     4741 ccacggtggg cgcccggcgg cgttgaccca ctgaccagtc gcatggttga ggcctccccg
     4801 ggccgtgcat ccagtaccgg cccggggagt gcccgctgcc gcgcgccgac ggccgtggcc
     4861 gtttcctggg acgccgggcc tcgttgaacc cggcatcgga caaggagcgg acgtttggac
     4921 gggccccgga accagcacgg tttccggggc ccacgtgtgt gccggacgcg tccgccccgg
     4981 cgagcacgag ggagacgccg atgaacgacg cgacgcactt ctggcgcatc agccgggcgg
     5041 gccgcacccg cccgcggggg cgggcccacg aacccgccgg gcccgcgtcc cgcaccgcct
     5101 ggcagccggt ccggcggggc ctgttgcggg ccgcgttcgt ctcggcgacc gtcgccttca
     5161 ccgccgccgt cctctcccgc atcccgggcg ccaccccgca gggcggaccc gcgggtgccc
     5221 ccgggccgga acccgatgcg ggcgccgcct tcgacgagat gcacgccgga caccgcatcc
     5281 agggctggcc gctcggggcg ggccgggccg agctcgccgt gttcgtggac ggccggcagc
     5341 tggacgtgat gcggcgggcg gacggcagct acctcagctc cgtcgaccac tacgtgtcgt
     5401 accccaccgc acgcgcggcc gcccgggccg ccgcgaacga gctgggcacc gcccgcctcg
     5461 ccgccgttcc cgtgcacggc agccaccagg agggagccgg ccgtggtgta cacgcgtaag
     5521 aaccagcgga acctgacgag cgccgagcgc aaggccttcg tgaacgcggt gctcgaactc
     5581 aaacgcagcg gcgtctacga cgagttcgtg cgcacccaca tcgagttcta cgtcccggac
     5641 ggcgacgacg ggctgcgggt cgcgcacatg acgccgtcgt tcctgccctg gcaccgcaag
     5701 ttcctgctcg aattcgagca ggccctccag aaaatcaact cccgtgtgac ggtgccctat
     5761 tgggactgga cgcgggaccg ttcccccgcg tcgtccctct ggtccgacga cttcatgggc
     5821 ggcaacggcc gccgcggcga cctgcaggtc atgaccgggc cgttcgcgta cgcgcacggc
     5881 aactgggacc tcgcggtcga ggtcaccgag gcccgcttcc tgacccggga cctggggcgc
     5941 cccaacgacc ccatcgccct gcccgtcgcc gccgacgtcg accgggcact cgccgacccg
     6001 gtgtacgaca ccgcgccctg ggactccacc agcgggtccg gtctccgcaa ccgcatggag
     6061 ggctggacga ccgggctttc gggcagcgcc cgcttccgca tgcacaaccg ggtgcaccgc
     6121 tgggtcagcg gcgtcatgct gggcgccgcc tccgtcaacg atccggtgtt ctggctgcac
     6181 cacgcctaca tcgacagcct gtgggcccgc tggcaggccg cgcaccccaa gtcccagcgc
     6241 tatctgccgg ccacgccacc gccgtccggg gacccccagc acggccgggt ggcggccctc
     6301 cacgacccga tgccgccgtg gaacgtggca ccggcggcgc tgctcgacca caccgcgatc
     6361 taccggtacg cctgacacgg cgacggcctc ccggggggag aagtccggga ggccgcggta
     6421 ctgctgtgag ccatgaccgg ccgggccacc gtgagggggc ccggccgaag cggggggtaa
     6481 ttactccccg tagccgccct cgtggtggct gtcggcgttg acgcaggtgt tgccgaacgc
     6541 ggggttcagc agcccgatga cgttgaccga gttgccgcag aggttgaccg ggacgtgcac
     6601 cggcacctgg agcaggttgc cggacaggac gccgggggag ttcgcagcga cggcctcggc
     6661 gccggcgtcg gccgaggcga tacccgcacc ggccagcgcc atggcgcctg ctccggcgac
     6721 gacggcggcc gtcttcgcga tacgagacat caaagttctc cttgatatgg acacgcgacc
     6781 gcagacacgc agtcgtcatt tcacttcaac gtgccgaacg ggcataagta acggacacct
     6841 gcgcccaaaa cggttctgca cggccgaccg gcgcaaggac tgccgctact tgccgtagcg
     6901 gctgcgggag acgcgtcgcg agagggcgac cgccgccgtg cccgtgacga ccgcgccgac
     6961 gctcagcgcg ccgagcagcg aggcccgcga gtcggcgccg gcgtgggcga gttgcggcgg
     7021 ggccggggcg gggtggtcga cggcgtgcgc cgcgtacccc gtgccgagca cggagaccag
     7081 cgccgcgacg agggcggcgc gcgccgcggg acccgagaac ctcgagaact tggacatgcc
     7141 tgcgaccctt cgacaggaag acgggggagg gggaggcgca tcagatgctg atacgcgtaa
     7201 ttcattgggt cggatcggct ccgccccggt cccccggcca cgcgcgccgc agccgacaga
     7261 caacccgtcc ggcgcagccc ccggcccccg cacggcccag tgcgcgggcc gtccccgagg
     7321 gcggacgccg ggccgttcac cgggcgccga gataggcccg ggccgcccgc ggattcgtgc
     7381 cgcactccca caggccgtgc gggcagtagt cggtcagggt ctggtagacc ggccggtacc
     7441 gccggaacca ggcggtcatc ccgcgcacgt acgccgggtc gtccccgttg cggaagaggc
     7501 cccactccgg gtacgagacc ggcttgtggt ggcgggcggc gaagtcgacc tgggcccgca
     7561 gcccgtacgg ctcctcgacc tgctgggcga acgacatgcc cgcgggctgg tcgtaggcgt
     7621 ccatgccgag gacgtccacc cagtcgtccc ccgggtagca cgcggtccac ggcaccgcgt
     7681 cccgcccccg gctcggcgcg aagtcgaagc ggaaccgctg ccccgtgacc gaccgcatcg
     7741 ccgtcacgac gcggcgccag tacgtccgcc acgcggcggg atcggggccg caccggtggg
     7801 tgtaggtgac gccgttcatc tcccagccca acaccacgat cgtgtcggcg agtcgaaggg
     7861 cgaccagacg ctcggccagg gtccggaagt gggcgtcgaa ggcgccccgc gaggcctggc
     7921 cgagcagggc cgctacccgc gcgtcgggca cgccctcctc gttgtggtcg agcatcggca
     7981 cgttgaggac gaggacgcgg tccgtgcgct gatcgcgcca gcgcgcccag ggggcgagca
     8041 gccccggcgg cccctcgatg tcgttccagg tgccgcccgg caggtaggtg tggcccacgc
     8101 gcagcggccc ccggccgcgc catttctcgg ccgccgcgag cctgccgacg ccggccccgt
     8161 ccgagcccgt gaagatgctc gccgcgttgc ccgacggggg aggcgccggg cccggccgcc
     8221 cgctgtcgga cgcgagcggc acgagggccg agagcagcag gaccagcacg cacagcgcgc
     8281 acttccacgc ggccgggccg gcgccggacg ggtgcacggg gccccgggga gcggcgctgc
     8341 ggcgggtcct ggccgtcagt ggcccgcgga cggggagcca ccgcgctgga gcgccccgct
     8401 cagcgaggcg acacccgagg tcagcgtctc gccgatcttg ccgcgcccgc cgaggacctt
     8461 gggctgcccg aactcgctga cactgccctg cccggcgacc ccgtcgtcgg ccgcggcgat
     8521 gccgggcgcg gccaggagca ggagggacgc ggcgacggtg gcggccttga ggcggtggtg
     8581 agtgttcatg cccggtacaa cgccgctcgc ccggtgaggg tgcgcggcgg tcgggcggtc
     8641 acgtcctggg cgcgtcgaag gcgaagggct gcctgcgcac ccggtggtcg aagttggacg
     8701 tgcccaactc cggttccccg agcgtgcgta cggcgatcgg acgggtcagc agctcgcgca
     8761 gtacggcctt gatctccagg cgggccagat gcgcgcccag gcagtagtgc gggccgccgc
     8821 ccccgtagcc caggtgcggg ttggggtcgc gggtgatgtc gaaggcgtcc gggtcggtga
     8881 agacgccggc gtcccggttg gccgacgcgt acaggagcat caccttgtcg ccgggcagga
     8941 acgtgtggcc ggacaggacg tagcgcgagg tgacggtccg gcggaactgg atgatgggtg
     9001 tggagtgccg cacgatctcg tcgaccgcgc tgtccgcgta gcgctcgaaa tcccctcgca
     9061 gcaaggccag ttgatccggg tggtcggtca gcagggacag ggcgtgggcg atggcgttgc
     9121 gggtcgtctc gactcctgcc acgagcaaca gggagaagaa cgaccccagt tgacggtacg
     9181 tcaggcgctg gccttccacg tccgcgcaca ccagcgccga gatgaggtcg ccggtcgggt
     9241 tccggcgccg ctcccgcccg agacgggcca cggtcagctg catccgggcc agcgcccgca
     9301 gtccctttcc ggggctgagc agccgggcgc cgatgctgcg ccgcaccccg gcgtgctccg
     9361 atgcccggtc gatctggcgg gcgatccggc ggcggtaggc gtcgggcacg ccgagcatgg
     9421 cgcagatgac ctcgaacgac atccgggagg cgaccgcgga gacgaactcg tcggggcgct
     9481 cggcgaccat gtcgtccacg atgcgcacgg cgagctcgcg gatgctgacc tcggtggcgg
     9541 cgagcaggcg cggggtgaac gcctgctgca cgatgcgcct caggcgcgtg tggtcggcgc
     9601 cgtcgaggtt gaccatcgag tcgccgaaca cggcccgcac ccagcgggcc ggctcgggcg
     9661 aagtgacgcc gggcgcgctc gcgaagaccc gcggaaggcg gctcgccttc agcacgtcgg
     9721 cgtgccggac cagggcgtag aagccctgct cggggcggcg ccggccggcc cggcgttccg
     9781 tgaagaagac cgggcgcggc tgctgtctca actcggcgaa acgcgcgagg cgttgggtgg
     9841 gaggctgctt ccagaacgcc gggtcggcga gatcgccggt ggcgccgcgg ggcgccggga
     9901 ccgtccgggg gtgagtcacg cgcgcaccgt cctggccgcc tcgcggctgt cgaacaacac
     9961 tgtcgggcag gggagttgag ggcggccgaa gcgtcagccg accagggcgt gtccggcctt
    10021 gaccgcgtcg ttggcggcct tcaccgcctc gccgccggcc ttcacgccgt ccttcacggc
    10081 ggtcaccttc tggcccacct tgtccccgac gacgctgttc gcggcgggct tgatctgggc
    10141 accggcggcg ctggtggtgc gcgccgcacc gctgagggtg ccgccgaggt cgaaggcgtg
    10201 cgcggagggg gcgatgacgg cggcgagggc ggttccggcc gcggcggccg cgaggtatcg
    10261 acgtacgttc atgccgccta caacgcacga gccgggcgga gggcacgccc cgtgcctcca
    10321 tgcgccgcgc acgggggccg cgttgctgca agcaggggaa ctttgcagtg ataccgccgc
    10381 cgggatcgtt cttgctgaaa gacacggccg agtaggccac cagggaagga agagaacacc
    10441 catgggaatc acttcacgcg cgggcctggc gggcatcatg gcatgcatgg cgaccgcggc
    10501 cgccgtggca ccggccgcc
//
