LOCUS       NZ_BMUU01000001        10390 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence01, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000001
VERSION     NZ_BMUU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1270804)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1126560
            Orig. end                         :: 1136950
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10390
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="12"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10390
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10390
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5390](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5390
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    522..535
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    918..933
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            1102..2262
                     /db_xref="GeneID:96289036"
                     /locus_tag="IE233_RS04935"
                     /old_locus_tag="GCM10010326_10270"
     CDS             1102..2262
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144514.1"
                     /locus_tag="IE233_RS04935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10270"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_161253121.1"
                     /transl_table=11
                     /translation="MVIRSGFRSMAALTATAAIGLCWLAPTPDSSASSPAQVPGAGQQV
                     SPRPGAPALPGDVSALSYVVADARTGKVLAARDAHRKLPPASTLKTLFAVTALPHLHAE
                     DRHTVSEHELAGIGPGSSLVGVEAGHTYQVSDLWRGVFLSSGNDAVHVLASLNGGWEET
                     AAQMQAQARRLGALDTEVVSPDGYDTPGQVSSAFDLAVFGRAGLARPDFAEYCSTASAQ
                     FPGGGGSYGIMNTNRLLSGTDGISRYPGIVGVKNGYTTNAGNTLIAAAKQGDRTLLVTV
                     MNPQAGGGFAVYDEARTLLDWGFAAWDHVDSVGSLEPVRAKSPQRQAQIAHVAAVKPEA
                     AADDDEPGWTLTSSAAAGIAVAGTLFLVVRRRRVVRARTERSRPTE"
     misc_feature    2489..2503
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.59"
                     /tool="antismash"
     misc_feature    2521..2532
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.75"
                     /tool="antismash"
     misc_feature    complement(2557..2571)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            2729..3175
                     /db_xref="GeneID:96289037"
                     /locus_tag="IE233_RS04940"
                     /old_locus_tag="GCM10010326_10280"
     CDS             2729..3175
                     /codon_start=1
                     /db_xref="GeneID:96289037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087908.1"
                     /locus_tag="IE233_RS04940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10280"
                     /product="subtilase-type protease inhibitor"
                     /protein_id="WP_161253118.1"
                     /transl_table=11
                     /translation="MRKIAAAGAVIVALLANGLIGTGLGSAAAAPAEAMKPLSLYPPSA
                     LVISIEPGTGDQGASVQRAVTLSCAPTPSGTHPAPGAACAELKGVQGDFNALVASGAPR
                     LCTQVWQPVTVRADGVWNGKRVSHVQTYANSCLKAAGSEAVFNF"
     misc_feature    complement(3349..3362)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.85"
                     /tool="antismash"
     gene            3381..4472
                     /db_xref="GeneID:96289038"
                     /locus_tag="IE233_RS04945"
                     /old_locus_tag="GCM10010326_10290"
     CDS             3381..4472
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151157.1"
                     /locus_tag="IE233_RS04945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10290"
                     /product="phosphatidylinositol-specific phospholipase C
                     domain-containing protein"
                     /protein_id="WP_229892183.1"
                     /transl_table=11
                     /translation="MSDPRPRRFTPRPRTALLGALAACLALATAGAGGSASAAGPETLP
                     LSGATVSGLHNTYDPAAFSYLAQALDSGTSMIELDVWDDFITKEWKVSHSNPLGNSNNC
                     VNASTPAQLYTGGANKNLESCLDDVRVWLGAHPGHPPLVIKLEMKAGFQATYGMSPAKL
                     DQTISDHLGSAVFRPADLLTKPGGGQYATLDEAAGAGNWPTRQALAGKVMLEVIPGTVE
                     EGNPTDTLWTDVEYARYLRDLAAAGRTGQAQIFPAVHNAQAGDPRSRYADASIRPWFVV
                     FDGDAATYLGGTIDTAWYDTHHYFLVMTDAQNVAPALDDKNPSPADAQARVARLAAAHA
                     SVASNDWTSLPQIQSLALPRGVG"
     misc_feature    4669..4678
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    complement(4720..4737)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.58"
                     /tool="antismash"
     misc_feature    4727..4741
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.6"
                     /tool="antismash"
     gene            5001..5390
                     /db_xref="GeneID:96289039"
                     /locus_tag="IE233_RS04950"
                     /old_locus_tag="GCM10010326_10300"
     CDS             5001..5390
                     /codon_start=1
                     /db_xref="GeneID:96289039"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890875.1"
                     /locus_tag="IE233_RS04950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10300"
                     /product="apotyrosinase chaperone MelC1"
                     /protein_id="WP_161253115.1"
                     /sec_met_domain="melC (E-value: 1e-45, bitscore: 151.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPSRPSRPTRRQAIGVTAGTLAGLALAGTAHAAVPSGRTDAHT
                     GHDAPEAFDEVFQGRRIQGAPAAGHMHHGGGYGVRIDGQELHVMQNADGTWISVVNHYE
                     TFATPRAVARAAVVELQGASLVPLA"
     gene            5445..6272
                     /db_xref="GeneID:96289040"
                     /locus_tag="IE233_RS04955"
                     /old_locus_tag="GCM10010326_10310"
     CDS             5445..6272
                     /EC_number="1.14.18.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="IE233_RS04955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10310"
                     /product="tyrosinase MelC2"
                     /protein_id="WP_161253112.1"
                     /transl_table=11
                     /translation="MAVRKNQADLTATEKRRLVDALLQLKRSGRYDTFVSTHNAFIMSD
                     TDTGDRVGHRSPSFLPWHRRFLIEFEQALQSVDASVTLPYWDWTVDRTPTASLWAADFL
                     GGTGRSRDGQVMDGPFAQSAGGWPLNVRVDGRTYLRRALGASVAQLPTRAEVDSVLAMT
                     TYDMAPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGQMATGASPNDPVFWMHHAFVDKL
                     WSQWQTKHPASPYLPAAGTRDVVDLHDTMRPWNNVTPADMLDHRGYYTYDTAA"
     gene            complement(6295..7095)
                     /db_xref="GeneID:96289041"
                     /locus_tag="IE233_RS04960"
                     /old_locus_tag="GCM10010326_10320"
     CDS             complement(6295..7095)
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471432.1"
                     /locus_tag="IE233_RS04960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10320"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_190026301.1"
                     /transl_table=11
                     /translation="MTEDEGYLLDNRQAEAGERFDALAELFDAATFRHFHALGLTAGHR
                     VWEVGAGGLSVPGGLAERVGPEGYVLATDLDTGWLTGVTPPPPVEVRRHDIGRDEAPSG
                     SFDFVHARLVLVHVTDRARALRTMAGALRPGGVLFVEDADPALQPLLCLDEYGPEQERA
                     NRLRRAFRRLLAERGADLSYGRKLPRLLRELGLERVEADAYFPVTSPAGAVLEAATVRQ
                     VRDQLVDKGLADDEDIERHLASVAAGRLDLATSPMISAWGRRPA"
     gene            complement(7115..7993)
                     /db_xref="GeneID:96289042"
                     /locus_tag="IE233_RS04965"
                     /old_locus_tag="GCM10010326_10330"
     CDS             complement(7115..7993)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289042"
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980847.1"
                     /locus_tag="IE233_RS04965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10330"
                     /product="ABC transporter permease"
                     /protein_id="WP_161253106.1"
                     /transl_table=11
                     /translation="MSAAPAAPQPASAEALDTAGGEKTGALDLLLVPPRARTGWRLLPA
                     RIGALCTVELQKLRHDRAELYTRAVQPALWLLIFGETFTRIKAIPTGGIPYIDYLAPGI
                     IAQSAMFIAIFYGIMIIWERDSGILTKLLVTPTPRSALITGKAFAAGVKALIQAVVVIV
                     IAALLGVALTWNPLRLLGVAVAVILGSAFFSCLSMTIAGIVLTRDRLMGIGQAITMPLF
                     FGSSALYPVSIMPGWLQAVSKANPLSYQVDALRGLLLGTPSHLALDYGVLLLAAALGIL
                     AASSLLGRLAR"
     gene            complement(7953..8807)
                     /db_xref="GeneID:96289043"
                     /locus_tag="IE233_RS04970"
                     /old_locus_tag="GCM10010326_10340"
     CDS             complement(7953..8807)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289043"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602565.1"
                     /locus_tag="IE233_RS04970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10340"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190026302.1"
                     /transl_table=11
                     /translation="MSDDDARTGGEAVRCDGLEYAFGQTRAVDGLDLTVATGEVFGLLG
                     PNGAGKTTAIRCITTLLPVPAGRVRVFGHDAAKERMAVRRLLGYVPQQLSADSGLTGRE
                     NVALFARVFDVPRKERARRVEQALYAVDLTESADRMAKTYSGGMIRRLELAQALVSAPR
                     LLMLDEPTIGLDPIARTSVWEHINAVRRATGMTVLVTTHHMDEADQYCDRLALMHRGRV
                     RALGTPDGLKAELRERRGASGPDDPPPTLEDVFRDVAGRGLDSQGGDFRDVRSTRRTAT
                     RLG"
     gene            complement(8804..9268)
                     /db_xref="GeneID:96289044"
                     /locus_tag="IE233_RS04975"
                     /old_locus_tag="GCM10010326_10350"
     CDS             complement(8804..9268)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96289044"
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602566.1"
                     /locus_tag="IE233_RS04975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_10350"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_161247007.1"
                     /transl_table=11
                     /translation="MAAEEPEPFDDSFADVLAAVQRLVRRRLRRGLSAPRLRGAHIELL
                     RLVATRPGIGVSAAAKELYLAGNSVSTLVNQLVKGGYMRRETDPGDRRSARLHVTPAAQ
                     ERLHDWQRRRAALMGEQVARLDPADRAALAAAMPALRRLAENLHEEAEGS"
     misc_feature    9771..9785
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.38"
                     /tool="antismash"
     misc_feature    9901..9915
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
ORIGIN
        1 cgagcacggc ctggaagtcc gcctgcgaga agtactcgcc cgagtcactg cggccgttca
       61 tgccggagaa accctcgtgg gcgtaggcgg tcgcggcgga ccagccgaag gtcgactgga
      121 gtacggagtt gaagttggtc agggcactgg tctgggcggc ggccccgctg aaccctccgt
      181 cgaacggcat gatcgagaag ttgtccggga cgaagccctg ggtcttggcc tcgttcagca
      241 tctgcttgcc gaaccagccg gtgccgtcgg cagtcccggc ggtggtgacc gagacgtaca
      301 ggccggggtt gttctgctgg aggatcttgg cggcgcctat ctcgtgcgag atggcggcgg
      361 tgttctcgta ctccggctct tcgaggtcga agtcgatcgc cttgagctgg tacttcgtaa
      421 tgacctgctg gtacgcggcg gcggtggagg cggcgtccga acagttctgg cccagcttgg
      481 tgccgccgta cccgccgacg gagaccgaga cgtctccgcc cttggcccgg atcgagccga
      541 tgaccgcggc gaccgcggtg tcggaggaga cgggggccgt tccgccccaa gtcgggctgc
      601 acccgccccc gttgggggcg aggacgaagg ccagctggaa ggccttgagc ccggtggcgt
      661 ccatgatcgc ggaggtgtcg ggcgggttgt tgtcgagggg catcagatag ggagcggcgg
      721 cgtaccagcg gctgccgagc ccggcggcgc cggtggtcgc gccggacgcc tgtcccgcga
      781 cgagggcggt gaggcccgcc gcggcgagtg cggcgctggc ggcgccgcac aggagagcac
      841 gaagtggctt catgtcgagg tctcctgggg agggaggggg atcccagaat tgagcggtgg
      901 ccggaacacg tcaacgactt ggactagacc attgctcttc cttgaacaaa gaccgccggg
      961 ccggtgaacg gagccgtgcg gggcggcgtc tcccccgcgg gccccgcccc gtggacagag
     1021 ccgcccggtc gagtgccttc cgtgtaggcc ggacggcaca gccgacctgc gtgatgcccg
     1081 ttctgttcct acggtggctg aatggtcatc agatccggtt tccgttccat ggcagcactc
     1141 accgccactg ccgccatcgg tctgtgctgg ctcgctccga cgcccgacag ctccgcctcc
     1201 tcgcccgcgc aggtcccggg ggcgggccag caggtcagtc cccggccggg cgcccccgct
     1261 cttccgggtg atgtgtccgc cctgtcgtac gtggtcgcgg acgcccgcac cggcaaggtg
     1321 ctcgccgccc gggacgccca ccgcaagctg ccgccggcca gcaccctcaa gacgctgttc
     1381 gccgtcacgg cactccccca tctgcacgcc gaggaccggc acacggtctc cgagcacgaa
     1441 ctggccggca tcggcccggg cagcagcctg gtgggggtcg aagccggcca cacctatcag
     1501 gtgtccgatc tgtggcgcgg cgtctttctc agctcgggca acgacgccgt gcacgtactg
     1561 gcctcgctga acggcggctg ggaggagacc gcggcccaga tgcaggccca ggccaggcgg
     1621 ctcggcgccc tggatacgga agtcgtctcg cccgacggct acgacacccc gggccaggtc
     1681 tcctccgcgt tcgacctcgc ggtcttcggc cgcgccggcc tggcacgccc ggacttcgcc
     1741 gagtactgct cgacggcgtc cgcgcagttc cccggcgggg gcggctcgta cgggatcatg
     1801 aacaccaacc ggctgctctc gggcacggac gggatctccc gctacccggg gatcgtcggg
     1861 gtcaagaacg gctacacgac gaacgcgggc aacacgctga tcgcggccgc gaagcagggc
     1921 gaccgcacct tgctggtgac cgtcatgaac ccgcaggccg gcggcggctt cgccgtctac
     1981 gacgaggccc gcaccctgct cgactggggc ttcgcggcct gggaccacgt cgactcggtg
     2041 ggctccctcg aacccgttcg ggccaagtcg ccccagcggc aggcgcagat cgcgcacgtc
     2101 gcggccgtca agcccgaggc cgccgcggac gacgacgagc ccggctggac gctgacgagc
     2161 tcggcggccg cgggcatcgc cgtggccgga accctgttcc tggtggtacg ccgccgccgc
     2221 gtcgtccgcg cccgcaccga acggagccgc cccacggagt gagctcccgg cggcgtcccg
     2281 gccaccggga cgccggggcg tcgccgtggc cgcgcggttc cggatgggcg ggggggggcg
     2341 gaccacgtcc gtccgaaaga cggacccgcg catctcccgg gcgacggccc cgggtgccct
     2401 ccgagggcgc cccggacggt ctccgggagg aggctcccgg ggggccgacg gccgcacatc
     2461 cggatctgac cacccctcaa acaggcctaa gattcataga attcagcctt ccgttgcctg
     2521 gaaaacgact tcacacctgc cttcatgcct ttcttttggc cgaccttgac cgactcggcg
     2581 acctgcacac cccttcggcc gcctgcaccg atgcggcttc gttgagtgac ttcgtgtgac
     2641 cgaatgtgtc cggcgtggct cacgggaccg cccgccgcag gacagactcc tgttcgttct
     2701 tcggaaacca accccaggag tgttcgaaat gcggaagatc gcagcagccg gcgccgtcat
     2761 tgtcgcccta ctcgccaacg ggctcatcgg caccgggctc ggcagcgcgg cagcggcgcc
     2821 ggccgaggcc atgaagccgc tgagcctgta cccgccgtcg gccctcgtca tcagcatcga
     2881 gcccggcacc ggcgaccagg gcgcctccgt ccagcgcgcc gtcaccctca gctgtgcccc
     2941 gacaccctcc ggcacccacc ccgcaccggg cgcggcatgt gccgaactca agggcgtaca
     3001 gggtgacttc aacgccctcg tggccagtgg cgccccacgt ctgtgtaccc aggtgtggca
     3061 gccggtgacc gtgcgggcgg acggcgtctg gaacggcaag cgcgtcagcc acgtccagac
     3121 gtacgccaac tcctgcctca aggcggccgg ttccgaggcc gtgttcaact tctaggcgac
     3181 ccgacatcgg ggaggcttgc gactccccgt ctccgaagcc aggttgaccc ccgtcgaccg
     3241 tcacacgagc accatctgcg accggaccgg ccgcaggggg tgacagaagg aatccaactc
     3301 gtgttacttg acatgtcttc gtcgcttcac tcgacgatga caccgtcctg acggagagtc
     3361 accccccact aggaggaccc gtgtcggatc cccggcccag acgcttcacg ccccggccgc
     3421 gcaccgctct gctcggcgcg ctcgccgcct gcctcgccct cgccacggcg ggtgccggcg
     3481 gcagcgcatc cgcggcgggg cccgagaccc tgccgctgtc cggggccacc gtctccgggc
     3541 tgcacaacac ctacgatccg gcggccttct cctatctggc acaggccctg gactccggca
     3601 cctcgatgat cgagctcgac gtctgggacg acttcatcac caaggagtgg aaggtcagcc
     3661 actccaaccc cctgggcaac agcaacaact gcgtcaacgc cagcaccccc gcccagctct
     3721 acaccggcgg cgcgaacaag aacctggaga gctgcctcga cgacgtacgg gtgtggctcg
     3781 gcgcccaccc cgggcatccg ccgctcgtca tcaagctgga gatgaaagcg ggcttccagg
     3841 ccacctacgg catgagcccc gccaagctgg accagacgat cagcgaccac ctgggctcgg
     3901 cggtcttccg cccggcggac ctgctcacca agcccggcgg cggacagtac gccaccctcg
     3961 acgaggccgc gggcgccggc aactggccga cccgacaggc actcgcgggc aaggtgatgc
     4021 tcgaagtgat cccgggcacg gtcgaggagg gcaaccccac cgacaccctg tggacggacg
     4081 tcgagtacgc gcgctacctg cgcgatctgg cggcggccgg ccgcaccggc caggcccaga
     4141 tcttccccgc ggtccacaac gcccaggcgg gcgacccgcg ttcacgctat gccgatgcct
     4201 cgatccgccc gtggttcgtc gtcttcgacg gggacgcggc gacgtatctg ggcggcacga
     4261 tcgacaccgc ctggtacgac acccatcact acttcctcgt catgaccgac gcgcagaacg
     4321 tcgcgccggc cctcgacgac aagaacccct caccggcgga cgcacaggcg cgggtggccc
     4381 ggctcgccgc ggcccacgcg agcgtcgcct cgaacgactg gacctccctt ccccagatcc
     4441 agtcgctggc cctgccgcgc ggcgtggggt agtccggctc cgccggacgg aaaggcggcc
     4501 acccggctcg cacgacagga gtgccggggc ggccgccttt ccttgccctc cacaccccgg
     4561 ttccgcgtgg tcgactccgc gccgacgcag gccggtggtc gaggaacggt gtccgcgaac
     4621 cgcccacgtc cggggcccgg ttcaggccag cggccgaacc gtggtgcgtg tttttggaca
     4681 gcttcggcgc gtgagcacag acacatcccc cgcatcaagg caacaagatt ttcacaaact
     4741 tggcatatgc cagagagaat cttcacccac ggctcccaag tgacgcgtgt tcagcaagat
     4801 cctccttgtt gaacactgca cttcgaatcg ggacatgtcc gcatagcggc caaccccccg
     4861 tccaccgctt cttgccaccc cacctcgacc ggtagggatg gatgtgcacc ggttcgccgg
     4921 gcatcccggc cgtgaccagg ccggtcgaat gctcccggcg gacccgcgcg ccaactcgcc
     4981 gcgaagcaat ggggatcgcc atgtctcaac cctcccgacc gtcccgaccc acccgccgcc
     5041 aggccatcgg cgtcaccgcc ggcaccctcg ccggactcgc cctggcgggc accgcgcacg
     5101 ccgccgtgcc cagcggccgc accgacgccc acaccggcca cgacgcaccc gaggcgttcg
     5161 acgaggtgtt ccaggggcgc cgcatacagg gcgcgccggc cgccgggcac atgcaccacg
     5221 gcggcggcta cggcgtacgg atagacggcc aggaactgca tgtgatgcag aacgccgacg
     5281 ggacctggat cagcgtcgtg aaccactacg agaccttcgc cacgccccgc gcggtcgccc
     5341 gcgccgccgt ggtcgagctc cagggcgcct ccctggtccc gctcgcctga tccggccacg
     5401 accgccttac caccctcgtc ccacgcccaa ccaggagcac agccatggcc gttcgcaaga
     5461 accaggcaga cctcaccgcc accgagaagc gccgactcgt cgacgcgctg ctccagttga
     5521 agcgcagcgg aaggtacgac accttcgtca gcacgcacaa cgcgttcatc atgagcgaca
     5581 ccgacaccgg cgaccgggtc ggccaccgtt caccgtcctt cctgccctgg caccgcagat
     5641 tcctcatcga gttcgagcag gcgctgcagt cggtcgacgc gtcggtgacc ctgccgtact
     5701 gggactggac ggtggaccgc accccgacgg cctcgctgtg ggcggccgac ttcctcggcg
     5761 gcaccggccg cagtcgggac ggccaggtga tggacggccc gttcgcccag agcgcgggcg
     5821 gctggcccct caacgtccgt gtggacggcc gcacttatct gcgccgggca ctcggcgcct
     5881 cggtcgccca gctgccgacg cgggccgagg tcgacagcgt tctcgccatg acgacgtacg
     5941 acatggcgcc gtggaacagc gcctccgacg gcttccgcaa ccacctggag ggctggcgcg
     6001 gggtcaacct gcacaaccgc gtccatgtgt gggtgggcgg ccagatggcg acgggggcct
     6061 cgcccaacga cccggtgttc tggatgcacc acgcgttcgt cgacaagctg tggtcgcagt
     6121 ggcagaccaa gcacccggcc tcgccgtatc tgccggcggc gggcacgcgg gacgtcgtgg
     6181 acctgcacga cacgatgcgg ccgtggaaca acgtgacccc cgcggacatg ctggaccaca
     6241 ggggttacta cacgtacgac accgcggcct agccgtcccg gccgccggtc gcgctcaggc
     6301 cggccggcgg ccccaggcgg agatcatcgg cgaggtcgcc aggtcgaggc ggccggcggc
     6361 cacgctcgcc agatggcgct cgatgtcctc gtcgtcggcc aggcccttgt cgacgagctg
     6421 gtccctgacc tggcgcacgg tggccgcttc gaggacggcg ccggccggcg aggtgaccgg
     6481 gaagtacgcg tcggcctcga cccgttcgag gcccaactcc cttagcaggc gcgggagttt
     6541 gcgcccgtag gacaggtcgg cgccgcgctc cgcgaggagt cgcctgaacg cgcggcgcag
     6601 acggttggcc cgttcctgtt cggggccgta ctcgtcgagg cagagcagcg gctggagcgc
     6661 ggggtccgcg tcctcgacga acaggacgcc gccggggcgc agcgccccgg ccatcgtgcg
     6721 cagcgcccgg gcccggtcgg tgacgtggac caggaccagg cgcgcgtgca cgaagtcgaa
     6781 gctccccgag ggcgcctcgt cccggccgat gtcgtgccgc cgcacctcga cagggggcgg
     6841 cggggtgacg ccggtcagcc agccggtgtc gaggtccgtc gcgaggacgt acccctcggg
     6901 gccgacccgt tcggcgaggc cgcccggcac cgagagacct cccgcgccca cctcccagac
     6961 ccggtgcccc gcggtcaggc cgagggcgtg gaagtggcgg aacgtggcgg cgtcgaagag
     7021 ctcggcgagc gcgtcgaacc gctcccccgc ctcggcctgc cggttgtcca ggaggtatcc
     7081 ctcgtcctcg gtcatgggga tcatgatggc agcctcagcg ggccagcctg ccgagcagcg
     7141 aggaggccgc gaggatgccg agggccgccg cgagcagcaa caccccgtag tcgagggcca
     7201 gatgggacgg ggtaccgagc agcagtccgc gcagcgcgtc gacctggtag ctgagcgggt
     7261 tggccttgct gacggcctgg agccagcccg gcatgatcga caccgggtag agggcgctgg
     7321 agccgaagaa cagcggcatc gtgatggcct gcccgatgcc catcaggcgg tcgcgggtca
     7381 gcacgatccc ggcgatcgtc atcgacaggc aggagaagaa ggccgagccg aggatcacgg
     7441 ccacggcgac gccgagcagc cgcagcgggt tccaggtgag ggccacgccg agcagggccg
     7501 cgatgacgat caccacgacc gcctggatga gcgccttgac gcccgccgcg aaggcctttc
     7561 cggtgatgag ggcggagcgc ggcgtcgggg tgacgaggag cttggtgagg atgcccgagt
     7621 cccgctccca gatgatcatg atgccgtaga agatggcgat gaacatggcg gactgggcga
     7681 tgatgccggg cgccagatag tcgatgtacg ggatgccacc ggtggggatc gccttgatgc
     7741 gcgtgaaggt ctcgccgaag atcagcagcc acagggcggg ctgtacggcc cgggtgtaga
     7801 gctccgcgcg gtcgtgccgg agcttttgca gttcgaccgt gcacagtgcg ccgatccggg
     7861 ccggcagcag ccgccagccg gtgcgggccc gtggcgggac gagcagcaga tcgagggcgc
     7921 cggtcttctc gccccctgcg gtgtcgaggg cctcagccga ggcgggttgc ggtgcggcgg
     7981 gtgctgcgga catcgcggaa gtcacctccc tggctgtcga gcccacgccc tgcgacgtcg
     8041 cggaagacgt cctccagggt gggcggcgga tcgtcggggc cgctcgcgcc gcggcgctcg
     8101 cgcagttcgg ccttgaggcc gtcgggcgtg cccagggcgc gtaccctccc gcggtgcatg
     8161 agcgcgagac ggtcgcagta ctggtcggcc tcgtccatgt ggtgggtggt caccaggacc
     8221 gtcatgccgg tggcccggcg cacggcgttg atgtgctccc acacgctggt gcgggctatc
     8281 gggtcgaggc cgatggtcgg ctcgtcgagc atcagcaggc ggggcgcgct gaccagcgcc
     8341 tgcgccagtt cgaggcggcg gatcatgccg cccgagtacg tcttggccat ccggtcggcg
     8401 gactcggtga ggtcgacggc gtacagggcc tgctcgacgc ggcgggcccg ctccttgcgg
     8461 gggacgtcga agacccgggc gaacagggcc acgttctcgc ggccggtcag gccggagtcg
     8521 gccgacagct gctgcggtac gtagccgagc agccggcgca ccgccatccg ttccttggcg
     8581 gcgtcgtgcc cgaacacccg gacgcggccc gccggtacgg gcagcagggt ggtgatgcac
     8641 cggatcgcgg tggtcttgcc cgcgccgttc gggccgagca gcccgaagac ctcgccggtg
     8701 gcgacggtca ggtcgagccc gtcgacggct ctggtctgcc cgaaggcgta ctccaggccg
     8761 tcgcaccgca ccgcctcgcc gccggtcctc gcgtcgtcgt cactcatgac ccctccgctt
     8821 cctcgtgcag gttctcggcc agccggcgca gtgcgggcat cgcggccgcc agcgcggccc
     8881 ggtcggccgg gtccaggcgt gccacctgct cgcccatgag cgcggcccgg cggcgctgcc
     8941 agtcgtgcaa ccgctcctgg gctgcgggcg tcacgtggag ccgggcggag cgacggtcgc
     9001 ccggatcggt ctcgcgcctc atgtacccgc ccttcaccag ctggttgacc agcgtggaga
     9061 ccgaattgcc ggccagatag agctccttgg cggcggccga caccccgatg ccgggccggg
     9121 tggcgaccag cctgagcagt tcgatgtggg cgccgcgcag ccggggcgcg ctcagcccgc
     9181 ggcgcagcct gcgccggacg agccgctgga cggcggccag cacatcggcg aaggagtcgt
     9241 cgaacggttc gggctcttcg gcggccatgt cctcatttta tctctcactc agaggtaatg
     9301 accagagggc gtcggtgccg caccagggcg atgcgccgcc aaacgcgacg ggagtgtggc
     9361 aagggacaca tgtggacccg ctgtgcgaac ggacgagggc cacatgacat ctttccccgg
     9421 ggccccgtgt gctccaccga acgtcattcg catcgggcag ggaaacagga gctgaacaca
     9481 cgtgccggcc atcagccaga ggatgcatct gatcctgctc tccgcatgga ccgcgctgtg
     9541 gttcgccgtg gtggagccca acggcggctt ctcctggcac tatctgcggg ccgggggcga
     9601 gctcatcttc cagggaccct ccggcgacgg caccggcgga ctcaatctct acgcgcacca
     9661 tcccgagctc cagatgggtc ccgtcagctt cctgacggcg ggcctcttca acccgttccc
     9721 cgagcggacc gggcagttcc tcgccgcgct cctcatgtcg gtgctcggcc tggtcatcgt
     9781 ggtcatcgcc gggcgcagcg ccgcgtggta cttcctggga accggcacca accaccagcg
     9841 gctgcggcag cgcgtgctga tcgcggggct cgccttcatc ccgatgtgga tcgaggtgtc
     9901 ggtgcgcttc ggccacctcg acgacgtgct cgccctgttc ttcaccgctc tcgcggtccg
     9961 ttcggtgacg cgcgacagtc cggtgggcac cgggatctgg ctggcgctcg cgatggactc
    10021 gaagccgacc gcggtgacgt tcgcggcgct cctcttcgcc ctgccccggc accagtggct
    10081 gcgggccggg ctgtggtgcg cggcggtgct cgcgatcgcc tgggcgccgt tcttcctcag
    10141 caatccgcac tcgatgtcgg cggccggctt cgcgataccc aaccagcccg cgtcggcgct
    10201 gcgctggctg ggcgtcgccg atgccgagac acccggctgg gaccggcccg cgcaggccgc
    10261 gctcggactg ctgctcggcg cgatcgcggt gtggcggggc cggtgggcgg cggtggtgct
    10321 gctcggcgcc aacgcgcgga tcgtgctcga ccccagcgtc tacacgtact acaccgcctc
    10381 cgtcctgctc
//
