LOCUS       NZ_BMUU01000001        21312 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence01, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000001
VERSION     NZ_BMUU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1270804)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1004421
            Orig. end                         :: 1025733
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21312
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="10"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21312
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21312
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11312](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11312)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     misc_feature    complement(366..380)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(523..1047)
                     /db_xref="GeneID:96288920"
                     /locus_tag="IE233_RS04350"
                     /old_locus_tag="GCM10010326_09110"
     CDS             complement(523..1047)
                     /codon_start=1
                     /db_xref="GeneID:96288920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998954.1"
                     /locus_tag="IE233_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09110"
                     /product="DUF6817 domain-containing protein"
                     /protein_id="WP_190026421.1"
                     /transl_table=11
                     /translation="MLEAAGAAKIEHPGGTLAAHLGRTSDLLAAWGARPALVSAGLCHA
                     FYGTDGFAVALLGLGRRDELVEAIGAEAEALVYFYASCDRGASYSQLADSEGVFVDRFT
                     GTHLRPGLPARRDFAELTAANELDLATVSPDFHARHGSGLHALFARWRPLLSSAARAHC
                     DNVLGAAPTGP"
     gene            1232..1459
                     /db_xref="GeneID:96288921"
                     /locus_tag="IE233_RS04355"
                     /old_locus_tag="GCM10010326_09120"
     CDS             1232..1459
                     /codon_start=1
                     /db_xref="GeneID:96288921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059185.1"
                     /locus_tag="IE233_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09120"
                     /product="DUF5133 domain-containing protein"
                     /protein_id="WP_161246634.1"
                     /transl_table=11
                     /translation="MLMAHPVVLRDLLAEYEVLVTLNAADGDEMTRQRLDDVTYTLCVS
                     TGTKDIDAAVVAARHRLPGARTFDDSVLTA"
     gene            1537..2355
                     /db_xref="GeneID:96288922"
                     /locus_tag="IE233_RS04360"
                     /old_locus_tag="GCM10010326_09130"
     CDS             1537..2355
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288922"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537523.1"
                     /locus_tag="IE233_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09130"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_229892172.1"
                     /transl_table=11
                     /translation="MRVVLTDFDASERRIWAGRAEAYAESFGKLCAHPVPRLLDAARVR
                     DGVRVLDVGTGTGTAAAAACARGARVTGVDAEISMVDLAARSVPSAEMHLAELPRLPFS
                     EGLFGAVTANFVLNHVGRPQAALAELRRVVRPGGWVAVTIWAAPAAAGQTLLDRAVQAA
                     GASRPPHLPALAPEDDFARTATGLTGLLASAGLKDATCEPLHWDHHTMAAAWWRGAAGG
                     IGTIGQTVLSQPEHVRAEIERHFHRISAEFATPEGHLALPHSALLAHGRR"
     gene            2580..3035
                     /db_xref="GeneID:96288923"
                     /locus_tag="IE233_RS04365"
                     /old_locus_tag="GCM10010326_09140"
     CDS             2580..3035
                     /codon_start=1
                     /db_xref="GeneID:96288923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559619.1"
                     /locus_tag="IE233_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09140"
                     /product="hypothetical protein"
                     /protein_id="WP_161248178.1"
                     /transl_table=11
                     /translation="MNLRPELTPPPVSRQRLDALRSDVERIAGLLDVHPEAAAEAIMAF
                     NATSGHDYNALDFAKHDGSRSLEEFAREAARPARPVVADITRDELVEIVRRLLMADPES
                     DFYLRLLEANVPHPRVRDLVFHPSDDLEDAFAEQLVDEALKYRPIAL"
     gene            3275..4822
                     /db_xref="GeneID:96288924"
                     /locus_tag="IE233_RS04370"
                     /old_locus_tag="GCM10010326_09150"
     CDS             3275..4822
                     /codon_start=1
                     /db_xref="GeneID:96288924"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036988.1"
                     /locus_tag="IE233_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09150"
                     /product="MFS transporter"
                     /protein_id="WP_190026235.1"
                     /transl_table=11
                     /translation="MTSSQPPPTIAATAPGSGGGGKGIALLVIAACQLMVVLDITIVNI
                     ALPHIQSALHFSTTGLAWVVSAYTLTFGGLLLLGGRTGDILGRRRVFMCGVLLFAVASL
                     LGGLSQSSGQLLAARAVQGVGGAIASPTALALITTTFTEGLERNRAFGVFAAVSAGGGA
                     IGLLAGGMLVEWLDWRWVLFVNVPIAVLILLATPRHIKESERHSGHFDIAGALASTGGM
                     VALVYGFIRAAQEGWRDPITLGSFAVAVVLLCTFVMVERRSQQPITPLHMFADRNRAGT
                     YGIMLSLAAAIFGMFFFLTLFVQDVLGFTPLRAGLAFLPVSAIIAVGAGLASQLLPRYG
                     PKPFMMAGALLAAGGLSWLTQTDIHSTYLGSILGPILVFGLGMGLNFVSLTLMAVSGVP
                     PHEAGAASGMLNATQQVGGSLGLSILVTVFGTASRNEATDQVPKFLSQADPAQRLMFRR
                     TGQLPRPWSDQVLASGVSTAFVVAAIFAVVAALIALIAIQVRPADLERLQGAKPTAP"
     gene            5063..6424
                     /db_xref="GeneID:96288925"
                     /locus_tag="IE233_RS04375"
                     /old_locus_tag="GCM10010326_09160"
     CDS             5063..6424
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288925"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE233_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09160"
                     /product="cytochrome P450"
                     /protein_id="WP_190026236.1"
                     /sec_met_domain="p450 (E-value: 6.3e-78, bitscore: 258.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATLPSRTGKAPGAWPLLGHAWQLHARPLEFLSSLPAHGDLVRI
                     GMGPWPAYVVCEPDAAHRMLTDSRTFDKGGPFFDKARGLFGSSLPMAGWQEHRWQRRQM
                     QPAFQSDRIERYALVMGEEVDRMTGRWRAGQRLDVTAALTTLTLRIVTRSVLAAEAQDE
                     AVAEVQESLHTVIDGIYQRVMLPLGPLYRLPTPANRRYRHACDRLHRAIDGIIAARRAA
                     PGGNDLVSMLLTAVNDDTGEPMSDVDIRDQLMVMIGAGFETTANSLAFALWLLSQHPEA
                     EARVHDEVDRTLAGRTATTADLDGLTYTRRVVNEVLRMYPAGWFFTRVTTTDTTLAGRH
                     LPKGTALLYSAYLLHHRPELFPEPGRFDPDRWAAQAAESLPRGAHVPFGGGNRKCIGDQ
                     FALIEMTLALATVCTRWRLRPDPGSTMTVQVRGTLGPGPLPMTCEPRGRKSADT"
     gene            6611..7975
                     /db_xref="GeneID:96288926"
                     /locus_tag="IE233_RS04380"
                     /old_locus_tag="GCM10010326_09170"
     CDS             6611..7975
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571325.1"
                     /locus_tag="IE233_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09170"
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="WP_190026423.1"
                     /transl_table=11
                     /translation="MSVAALAQAPDRRRTEAWLLAFVVAITLGGHAATGLAMKGRLPAG
                     FGTFAGAVALFALVPHLVVRRWAARADPLLLPLALLLTGLGLVLLQRLDVTYLAEPRLH
                     MVPAGRGQLVWTTVGVASCGGLLIALRDHRRLQRYIYLMMAVALILLAAPAFFSADQFG
                     AKRWIMLGPLSVQPGEFVKIMIAVFFAGYLTVNRDALALSGRRFLGMRLPPGRQLGPIV
                     AIWVLSLLVLVFERDLGTSLIFFGLFVIMLYLATERTSWVVCGLLLAVVGAAVVGSLEP
                     HVHGRVEAWLHPMDAFTPAGQKAHLSSQLGQALFSFGSGGMTGSGLGQGHPELVGFAGN
                     SDFILTTVGEELGLAGVMAVLLLYGLLAQRGLHIAMLARDPFGKLLATGLAGALVLQVF
                     VVTGGVTGLIPLTGKALPFLAKGGSSMVANWLMVGLLIRISDSARRRHEPDPHRP"
     gene            8101..8760
                     /db_xref="GeneID:96288927"
                     /locus_tag="IE233_RS04385"
                     /old_locus_tag="GCM10010326_09180"
     CDS             8101..8760
                     /codon_start=1
                     /db_xref="GeneID:96288927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059819.1"
                     /locus_tag="IE233_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09180"
                     /product="hypothetical protein"
                     /protein_id="WP_161256672.1"
                     /transl_table=11
                     /translation="MVDPGSTPAPSQRRRRGGCLPALVVLLVILGLGFGASKLFGGGSD
                     KSGSSHSSSSASHDSGEWKVGDCGGPDPDDAPNGYKAFGCGDSGATFKALDIQAASFMP
                     DSIQCPAGTDLIIQVSISYGSSKSKGGGIPSKTVCGRNLSADHPGDPGAGGGQLVKGDC
                     VTDTAKEVSCASAGSGAYKVLGLTKETSQCPSGTTEPMRLTLAIGRPYDVICAAKQ"
     gene            complement(8785..10008)
                     /db_xref="GeneID:96288928"
                     /locus_tag="IE233_RS04390"
                     /old_locus_tag="GCM10010326_09190"
     CDS             complement(8785..10008)
                     /codon_start=1
                     /db_xref="GeneID:96288928"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE233_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09190"
                     /product="cytochrome P450"
                     /protein_id="WP_190026237.1"
                     /sec_met_domain="p450 (E-value: 5.9e-25, bitscore: 84.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETAASAEPGIQSLDPAFFDHPHATYREWRQEGAARRARYPGPA
                     PVEGWVVTSYADAKDLLADQRLSKGGAVERFGRHVGLTQGPGSALFSHMLNSDPPHHTR
                     LRKLVQKAFTTRRTAALRPAIEAHVAGLLDAWEGRDEVELISEFALPLPLAVVFDLFGA
                     SDADHETLQVRGNTLDGGQGDGEVSVFTAESMLGYLRALLALKREQPDDGLLSALVEAG
                     AEGEEALSEDEITSMAFLLVIAGHQTTVNLIANGVHTLLTHPDQLALLRADMTLVPGAV
                     EEILRYESPSALASLRYAAEPVEVGEAVFGEGEFVQISLLGANRDPEVFADPDRFDINR
                     EDAARHLAFGHGIHHCLGAPLARLQAEIAFTQLLTRYPGLRLSEDHEARWQANPRHRGL
                     LSLPLRLT"
     gene            complement(10001..11059)
                     /db_xref="GeneID:96288929"
                     /locus_tag="IE233_RS04395"
                     /old_locus_tag="GCM10010326_09200"
     CDS             complement(10001..11059)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288929"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000172: Biaryl bond formation (67% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985364.1"
                     /locus_tag="IE233_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09200"
                     /product="cytochrome P450"
                     /protein_id="WP_229892174.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 1.1e-181,
                     bitscore: 599.5, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 1.1e-12, bitscore: 43.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTSRRTTVLAPRLQALLDEHLGKDLVRLEPDTIGIAGAELSDR
                     ILAARRATETERPTFKPLHGRSISKAEASSVMRTIGKDVRAALEQPDPLPASTDLSGPW
                     PITGHRFLSDLVLRDDPYRLRILMSRTLEIDPRLTWTTIVAGAALPRRPAPGPRLTHLA
                     NLFAEARTYDDRRYAMGIYRRAAAPVCFTVSTLVANALWLGSPFDDGASNRDILFEAMR
                     LLPPSWNLLRNRSPEYPAVDDRIGDGDDLLMLPLLTHRDPALWDAPNEFRPERWAGLDP
                     DNTPGYMPFGHVSERCWGRHMVMPLAELLLDHIRRTGLVVAPGQRTADVPLVGLLGVKT
                     VHIGHRSKVRHV"
     gene            complement(11172..11312)
                     /db_xref="GeneID:96288930"
                     /locus_tag="IE233_RS04400"
     CDS             complement(11172..11312)
                     /codon_start=1
                     /db_xref="GeneID:96288930"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_190026239.1"
                     /sec_met_domain="atropopeptide_precursor (E-value: 1.0,
                     bitscore: 1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGHPSGGSHPDITERKGLIMSKIIAALRAKKSEPSLKQAAWYFW
                     Y"
     misc_feature    complement(11256..11258)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11328..11339)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(11424..11435)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            11597..11848
                     /db_xref="GeneID:96288931"
                     /locus_tag="IE233_RS04405"
                     /old_locus_tag="GCM10010326_09210"
     CDS             11597..11848
                     /codon_start=1
                     /db_xref="GeneID:96288931"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_09210"
                     /product="hypothetical protein"
                     /protein_id="WP_161248875.1"
                     /transl_table=11
                     /translation="MSCPVCSSRRYPCRGGLTPGSAPSPGCPLSGEERALRVQRRERFR
                     EVRSRPEWNQGRARGRRSRVGLLAWAVLALLLLALFLL"
     gene            12037..12426
                     /db_xref="GeneID:96288932"
                     /locus_tag="IE233_RS04410"
                     /old_locus_tag="GCM10010326_09220"
     CDS             12037..12426
                     /codon_start=1
                     /db_xref="GeneID:96288932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950765.1"
                     /locus_tag="IE233_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09220"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_161248873.1"
                     /transl_table=11
                     /translation="MTRNRADATVAERFLTAFAAHDWEALHALFSADLAWSMPGDGTIS
                     GTVHGADAAVDRARKIAGRGLATELRHILTGVHGVALSLHNTAEDADGRALDEHLATVL
                     TIRDGKVCAIDSYVSDVDGMSAFFS"
     misc_feature    complement(12065..12079)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            12476..12910
                     /db_xref="GeneID:96288933"
                     /locus_tag="IE233_RS04415"
                     /old_locus_tag="GCM10010326_09230"
     CDS             12476..12910
                     /codon_start=1
                     /db_xref="GeneID:96288933"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS04415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_09230"
                     /product="hypothetical protein"
                     /protein_id="WP_190026240.1"
                     /transl_table=11
                     /translation="MNVSSEQHPHNARQLQAGQVVAIGWLLCGAALVERVPRFASGHRY
                     LLCHHSSVLDRLTLTALALVLAAGVVALAGAIMMQAKNPHRVAFPAVCLVVVAALLVAA
                     DGVDAHGENLATQLSATPFTAGACDYIPQDYVATPGWFFW"
     gene            complement(13005..13991)
                     /db_xref="GeneID:96288934"
                     /locus_tag="IE233_RS04420"
                     /old_locus_tag="GCM10010326_09240"
     CDS             complement(13005..13991)
                     /codon_start=1
                     /db_xref="GeneID:96288934"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823778.1"
                     /locus_tag="IE233_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09240"
                     /product="alpha/beta hydrolase family protein"
                     /protein_id="WP_190026241.1"
                     /transl_table=11
                     /translation="MRRVPVSTGVVAILVALLAAGFGAGTGHARDRFVRADDGARVVAE
                     QRIAPNRLDLTIDSPALGTTAHVRLLTPDGWSPGRHDWPSLWLLHGCCGGYTDWMTYSD
                     VAQLASLRRVLVVMPEAGAAGWYSDWWNYGRGGAPRWETFHTTEVRQIVERGYGAGGRR
                     VAAGLSMGGFGALSYAAGHPGLFRAVASFSGTVHPLLQVPGGPGPDWFLNLDRTQGVDP
                     YAVWGDPVRQRTVWAAHDPTVRASALRGLPLFLSCGNGEAGPYDPAGAKDPNEAYFERQ
                     NRALADRLGALGSPVLTDFYGPGTHAWPYWERELHRSLPMLLAALAG"
     gene            complement(14191..15660)
                     /db_xref="GeneID:96288935"
                     /locus_tag="IE233_RS04425"
                     /old_locus_tag="GCM10010326_09250"
     CDS             complement(14191..15660)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (65-218). E-value:
                     6.7e-17. Score: 53.4. Matches aSDomain:
                     nrpspksdomains_IE233_RS04425_Condensation_LCL.1"
                     /codon_start=1
                     /db_xref="GeneID:96288935"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1209: polyketide synthase associated protein papA3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006137064.1"
                     /locus_tag="IE233_RS04425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09250"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_190026242.1"
                     /sec_met_domain="Condensation (E-value: 1.2e-10, bitscore:
                     37.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRITDIHGCEVRPGRLVEWSLDPAMVEAATSQPDDSRPPAYVQES
                     HIRTARSVRQDGLFVPTWLGAAFDILGPVDLDVLEAALRTWTLRHETLRSGFRWVDDEM
                     RRFTAAPDAVALRREVVGDFPDAEELSHHLQDRFDVEADALGWPNFLYTAVVRPESTSV
                     YMAFDHSNVDAYSIQRIPAEIHELYSARAEGRTEETAPVGSYVDFCEIERASADQVDDT
                     HAIVARWREFITRCDGRLPAFPVDLGLEPGGGLPEQKLLYKMLVDDADAAAFSAYCRPF
                     GGGQVGILAATSLIVHDIGGEPVYRTVVPLHTRAKSRWADSVGWYVGGAPIEIPVAQAR
                     GFDDALKMVHGALRANKALAHLPIARVLRLLGSDFRPTSPDLYSIVSFVDARDIPGARQ
                     WDELRASALLRVSYGDQVCAWFTRLHGGLQLAIRYPDTAIAHKNIHRYAEQLHELITSI
                     ARDAPAVPPRPRSERPVPAPRLSSEVSQLSL"
     aSDomain        complement(15007..15465)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS04425_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="6.70E-17"
                     /label="IE233_RS04425_Condensation_LCL.1"
                     /locus_tag="IE233_RS04425"
                     /protein_end="218"
                     /protein_start="65"
                     /score="53.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: DHSNVDA"
                     /tool="antismash"
                     /translation="AAFDILGPVDLDVLEAALRTWTLRHETLRSGFRWVDDEMRRFTAA
                     PDAVALRREVVGDFPDAEELSHHLQDRFDVEADALGWPNFLYTAVVRPESTSVYMAFDH
                     SNVDAYSIQRIPAEIHELYSARAEGRTEETAPVGSYVDFCEIERASADQ"
     CDS_motif       complement(15367..15468)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS04425_0001"
                     /evalue="1.60E-08"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE233_RS04425"
                     /protein_end="98"
                     /protein_start="64"
                     /score="26.9"
                     /tool="antismash"
                     /translation="GAAFDILGPVDLDVLEAALRTWTLRHETLRSGFR"
     gene            complement(16260..16655)
                     /db_xref="GeneID:96288936"
                     /locus_tag="IE233_RS04430"
                     /old_locus_tag="GCM10010326_09260"
     CDS             complement(16260..16655)
                     /codon_start=1
                     /db_xref="GeneID:96288936"
                     /inference="COORDINATES: protein motif:HMM:NF014909.5"
                     /locus_tag="IE233_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09260"
                     /product="hypothetical protein"
                     /protein_id="WP_190026243.1"
                     /transl_table=11
                     /translation="MRRSTTVAAIALCGALAAGTAAPAYAAGQAPAVSVPGTGGESMGG
                     RAGDDDVAGVKAELAATMKDINQMIADEKKDAAADVAEAKAEVAAILKEISAMVKEELA
                     QAKPATKPSTAEPAPLSVPNTPPAATG"
     gene            16825..17373
                     /db_xref="GeneID:96288937"
                     /locus_tag="IE233_RS04435"
                     /old_locus_tag="GCM10010326_09270"
     CDS             16825..17373
                     /codon_start=1
                     /db_xref="GeneID:96288937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953032.1"
                     /locus_tag="IE233_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09270"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_190026244.1"
                     /transl_table=11
                     /translation="MGERVERVDEQDRVLGVVERGEAVREGWLYRMAMVLCRDERGRCL
                     VHRRPEGVSRFPGEYSWLVAGAVGVGEPYADAARRELREELGVDAPVRPLFKFLCDGEL
                     GPYWFAVYEAVVEEADVVADASEVAWHGWLTDDELRAAMASWKFVSDSRDAYTRYLALG
                     SSGQDSGAVDPAGHRVADE"
     gene            complement(17329..17616)
                     /db_xref="GeneID:96288938"
                     /locus_tag="IE233_RS04440"
                     /old_locus_tag="GCM10010326_09280"
     CDS             complement(17329..17616)
                     /codon_start=1
                     /db_xref="GeneID:96288938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019060897.1"
                     /locus_tag="IE233_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09280"
                     /product="hypothetical protein"
                     /protein_id="WP_161249248.1"
                     /transl_table=11
                     /translation="MSRRYGGNPAATGILVIVDVMALILILWIAFFLVNANTANDIVSW
                     VRHAADWLSGWSRDMFTIRDDTWRTIVNYGLPAVVYLLIGHAVAGRVNRS"
     gene            complement(17725..18465)
                     /db_xref="GeneID:96295759"
                     /locus_tag="IE233_RS39025"
                     /old_locus_tag="GCM10010326_09290"
     CDS             complement(17725..18465)
                     /codon_start=1
                     /db_xref="GeneID:96295759"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS39025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_09290"
                     /product="hypothetical protein"
                     /protein_id="WP_229892175.1"
                     /transl_table=11
                     /translation="MTKPERSASDQPLADKLVSGHDVPEQPGTHQPGIARDVPAGAAAD
                     QPLSGGAVPDRAAAGEPLTGRDVPERAAPDQSVAGRTATPDQSVTGRTATPDQALPDQP
                     GTGKHLTGQPAAGQPVSERSLSGHPVAEQPAAEGRVPEQAGRRTGAESGAVDDGAVLPP
                     HEREKLQLRLHHAVGGFVDEPRAAVEEAASAVDALTERIIETLGQRRGTLRASWQDASG
                     GSATEDLRMALREYRRLAERLLSL"
     gene            complement(18462..19094)
                     /db_xref="GeneID:96288939"
                     /locus_tag="IE233_RS04450"
                     /old_locus_tag="GCM10010326_09300"
     CDS             complement(18462..19094)
                     /codon_start=1
                     /db_xref="GeneID:96288939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006137656.1"
                     /locus_tag="IE233_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09300"
                     /product="hypothetical protein"
                     /protein_id="WP_190026245.1"
                     /transl_table=11
                     /translation="MSSGVVIILIAIVVIVVLAVVIGMFVARRGQGLRSRFGPEYERTV
                     AEHHGDVKAAEKDLDERVRRYGSLKVDPPSAEERSRYAAQWARVQEEFVESPTRAVAEA
                     EALLGRLANERGFPSGSSDEQLAALSVHHPQHLDSYRRIRGVAQGADGRRPSTEELRET
                     LVQAHEFFAVLTGERRGDKAGRLGVRGGRHASHSGTHHDDTARGSQS"
     gene            19302..19547
                     /db_xref="GeneID:96288940"
                     /locus_tag="IE233_RS04455"
                     /old_locus_tag="GCM10010326_09310"
     CDS             19302..19547
                     /codon_start=1
                     /db_xref="GeneID:96288940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="IE233_RS04455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09310"
                     /product="chaplin"
                     /protein_id="WP_373300108.1"
                     /transl_table=11
                     /translation="MVRIRTALAATVLAATAVIGTAGAAAADPNPPVVGTAQDSPGVLS
                     GDVIQVPVTVPVNACGDTIDLIGLLNPAAGNTCVNH"
     gene            19764..20063
                     /db_xref="GeneID:96288941"
                     /locus_tag="IE233_RS04460"
                     /old_locus_tag="GCM10010326_09320"
     CDS             19764..20063
                     /codon_start=1
                     /db_xref="GeneID:96288941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174059.1"
                     /locus_tag="IE233_RS04460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09320"
                     /product="hypothetical protein"
                     /protein_id="WP_161249254.1"
                     /transl_table=11
                     /translation="MSTASHTEHAEHTHEHGTGCGHVAVPHADHVDYVHDGHLHRSHDG
                     HTDECEPGGHTVHEDHTHRHQAGCGHVSVPHGDHVDYVHDGHRHADHDGHWDDH"
     gene            complement(20129..20863)
                     /db_xref="GeneID:96288942"
                     /locus_tag="IE233_RS04465"
                     /old_locus_tag="GCM10010326_09330"
     CDS             complement(20129..20863)
                     /codon_start=1
                     /db_xref="GeneID:96288942"
                     /inference="COORDINATES: protein motif:HMM:NF019619.5"
                     /locus_tag="IE233_RS04465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_09330"
                     /product="JmjC domain-containing protein"
                     /protein_id="WP_190026246.1"
                     /transl_table=11
                     /translation="MTGGLDGGLMRAPYVELVREGEVVPAAELGAAAGAAHGTEEGFAD
                     PERIMHLLAEGATLLLPRLGRWNASAGALTALLSQDLGRETEAFCFATTVGRSGRDVHC
                     DDADVLVVQLAGRKEWTVYEAPADGDGRPGAVRTPAAPALCTVIGAGDVLYVPRGAPHR
                     ASGEDGLSAHLALTIREAAKPAPDPAPRPIVEAELLATARELLASARARVQTLTHEGPL
                     ARTGGSPPSGARGIPADWPAAD"
ORIGIN
        1 ggtcgagctg gtgggccccg gcggggtacg gaccgtcccg ctgaccgagt tctatctgct
       61 gccacaggac aggcccgatc tggagaccgt catgcggccc ggcgaactcg tcaccgcggt
      121 gctgcttccg gccccgcccg cgggatccgt ctcccgctac cgcaaggccc gcgaccgggc
      181 gggctacacg ttcgcgctgg cctccgtcgc cgccgtggtg cggctggagc ggggtgcggt
      241 gcgtcatgtc accgtcgcct tcggcggcct cgcgcaccgg ccgtggcgag cgaggcggac
      301 cgaggcggcg ctgctcggca cgtcacccac gccggagagc atcgagcgtg cggtcgaggc
      361 ggaactggcc gacgccgtcc cgctgcggca caacgcgtac aaggtggagc tcgcccgggg
      421 cctggcccac gaggtcctga gcaccctgac cacacggccc ggcgccccct gaccacgtga
      481 ctacgggcca accggccgtc caccgtgccg tgttggcgga tgtcacggcc ccgtgggagc
      541 cgcgcccagc acgttgtcgc agtgcgcccg cgccgcggag gagagcagcg gccgccaccg
      601 ggcgaacagg gcgtgcaggc ccgagccgtg acgggcgtgg aagtcggggc tcaccgtcgc
      661 gaggtccagc tcgttggcgg cggtgagttc ggcgaagtcc cgccgggccg ggaggccggg
      721 acgcaggtgt gtgccggtga accggtcgac gaacacgccc tcactgtcgg ccagttggga
      781 gtaggaggcg ccgcggtcgc aggaggcgta gaagtacacg agcgcctcgg cctcggcgcc
      841 gatcgcctcc acgagctcgt cgcggcgccc caggccgagc agcgccacgg cgaatccgtc
      901 ggtcccgtag aaggcgtggc acagccccgc cgacaccagg gccgggcggg ctccccacgc
      961 ggccaagagg tcgctggtac gccccagatg cgccgccagc gtgccgcccg ggtgctcgat
     1021 cttcgcggcg ccggccgctt ccagcatgtc ccacgcctga gcattcacat gccggaacct
     1081 gcccgccccg cgtgccggga aatcccgtgg gtacggcgga gcttgggaca tccgcccgtc
     1141 aacaccgcct ggttcacgac gtgtagggca ggcgaagcgg ggcacgggag cagcacatcg
     1201 tgaacgtctc gaccaccgaa gggccccacc catgctgatg gcgcatccgg tagtgctccg
     1261 tgacctgctc gccgagtacg aggtcctcgt caccctcaac gccgccgacg gcgacgagat
     1321 gacgcggcag cgcctggacg acgtgacgta caccctctgc gtctcgaccg ggaccaagga
     1381 catcgacgcc gccgtcgtcg ccgcacgcca ccggctgccc ggagcccgca ccttcgacga
     1441 ctcggtgctc acggcctgaa cgaccgtccg ccccgggtac ggaccggctc ccgtagggtg
     1501 cccgaagtac ccgcgggggt acggcaggga gaggcggtgc gggtggtgct gacggacttc
     1561 gacgcgagcg agcggcgcat ctgggcgggc cgggccgagg cgtacgcgga gagcttcggc
     1621 aagctgtgcg cccaccccgt cccgcggctg ctcgacgcgg cccgggttcg cgacggcgta
     1681 cgcgtgctgg acgtcggcac cggaacgggc acggccgcgg cggcggcctg cgcgcggggc
     1741 gcccgggtga ccggcgtgga cgccgagatc agcatggtcg acctggccgc ccggagcgtc
     1801 ccctcggccg agatgcatct ggccgaactg ccccgactcc ccttctccga gggcctgttc
     1861 ggcgccgtga ccgcgaactt cgtcctcaat cacgtgggcc gcccccaggc cgcgctcgcc
     1921 gagctgcgac gcgtggtccg gccgggcggc tgggtcgcgg tgaccatctg ggccgccccc
     1981 gccgcggccg gccagaccct gctcgaccgg gccgtccagg ccgcgggcgc ctctcgcccg
     2041 ccgcacctgc cggccctggc ccccgaggac gacttcgcca ggacggcgac gggcctcacc
     2101 ggtctcctcg cctcggcggg cctgaaggac gcgacctgcg aaccgctcca ctgggaccac
     2161 cacaccatgg ccgccgcatg gtggcgcggg gcggcgggtg gcatcggcac catcggccag
     2221 accgtcctga gccagccgga gcacgtgcgc gccgagatcg agcgccactt ccaccgaatc
     2281 agcgccgaat tcgccacgcc cgagggccac ttggcgctcc ctcattccgc cctgctggcc
     2341 cacggccgcc gctgacgccc gcggtaccga agccgggcgc gccgcgcgag gggcgcgcga
     2401 gggccgtccg tctcggcacg gctccggcag gacgacgcct caacgcccgg gcggccgcgc
     2461 gggccgactt gacccccttc gcaagatgat cctgctccga taacacccag aacgcagaag
     2521 tggcagcacg gcagagggct ctgctctggc atgtctgcac cgggggacat aattcggctg
     2581 tgaacctgag accggagctg acacccccgc ctgtgagtcg gcagcggctg gatgcgttgc
     2641 gctctgacgt ggagcggatc gctggcctgc tggatgtaca cccggaggcg gcggccgagg
     2701 cgatcatggc cttcaacgcg acgagcggtc acgactacaa cgctctcgac ttcgcgaagc
     2761 acgacggcag caggagcctg gaggagttcg cgagggaggc ggcccggccg gctcgccccg
     2821 tggtcgcgga catcacccgg gacgagctcg tcgagattgt tcgcaggctc ctgatggccg
     2881 acccggagag cgacttctat ctacggctct tggaggcgaa cgtgccgcat ccccgggtga
     2941 gggacctggt cttccaccct tcggacgacc tcgaagacgc gtttgcggaa cagcttgtcg
     3001 acgaggctct gaaataccgg ccgatcgcac tctgagcgaa tcgaacgccg ccgtcatcgc
     3061 cgggcgccta gccctctgat cgcacactgt caggtgtatt acgcaggcgt actccgcagg
     3121 tgcaccacgc gggtgtactg cgcaggtgta ttacccccac acacataccc cgggcccgtc
     3181 gccgcttgat cgactggtga cgtgcggtac ccgggcatag ggtcgaacag tggacgtcac
     3241 cgtccatcgt ccctcgtgcg agggcaggtc catcatgacg agttcgcagc cgccacccac
     3301 gatcgcggcc acggcccccg gcagcggagg cggcggcaag gggatagcac tgctcgtcat
     3361 cgccgcctgc cagctcatgg tggtcctcga catcaccatc gtgaacatcg ccctcccgca
     3421 cattcagagc gcgttgcact tctccacgac gggactcgcc tgggtggtca gcgcctacac
     3481 gctcacgttc ggcggcctcc tcctgctcgg cggacggacg ggcgacatcc tgggccggcg
     3541 ccgggttttc atgtgcggcg tgctgctgtt cgcggtcgcc tcgctgctcg gcggactgtc
     3601 ccagagttcc gggcagttgc tcgcggcgcg tgcggtccag ggggtcggcg gtgccatcgc
     3661 gtcgccgacc gctctcgcac tgatcaccac gacgttcacc gaggggctcg aacgcaaccg
     3721 cgcgttcggc gtcttcgccg cggtgtccgc gggcggcggc gcgatcggtc tgctcgcggg
     3781 cggcatgctc gtcgaatggc tcgactggcg ctgggtcctc ttcgtgaacg tgccgatcgc
     3841 cgtgctgatc ctgctggcca ccccgcggca catcaaggag tcggagcgac attccggcca
     3901 cttcgacatc gccggagcac tggcctccac cgggggcatg gtcgcgctgg tctacggctt
     3961 catccgggct gcccaggagg gctggcgcga cccgatcacc ctgggctcgt tcgccgtcgc
     4021 cgtggtgctc ctctgcacgt tcgtgatggt ggagcgacgt tcgcagcagc cgatcacacc
     4081 gctgcacatg ttcgccgacc gcaaccgcgc gggcacgtac ggcatcatgc tgagcctggc
     4141 cgccgctatc ttcggcatgt tcttcttcct caccctgttc gtgcaggacg tgctcgggtt
     4201 caccccgcta cgggccggcc tcgccttcct gccggtcagc gcgatcatcg cggtgggcgc
     4261 ggggctcgcc tcccaactcc tgcccagata cggccccaag ccgttcatga tggcgggcgc
     4321 tctcctggcc gcgggcggcc tgtcgtggct cacgcagacc gacatccact ccacgtatct
     4381 gggcagcatc ctgggcccga tcctcgtgtt cggtctgggc atggggctga acttcgtctc
     4441 gctgacgctg atggccgtat ccggtgtgcc cccgcacgag gccggcgcgg cctccgggat
     4501 gctcaacgcg acccagcagg tgggcggttc actgggtctt tccatcctgg tgacggtgtt
     4561 cggcacggcc agccgcaacg aggcgaccga ccaggttccc aagttcctca gccaggccga
     4621 tccggcgcag cgcctgatgt tccggcgtac gggccagctg ccccggccgt ggagcgatca
     4681 ggtgctggcg tccggagtgt ccacggcctt cgtggtcgcc gcgatcttcg ccgtggtggc
     4741 cgccctgatc gccctcatcg ccatccaggt ccgcccggcc gacctcgaac gcctccaggg
     4801 tgcgaagccc accgcgccgt gagaccaggc ccggcatccg acggataccc gttgcgccaa
     4861 ctaccgggca cagcaaggga tatgacgggc catacgcaac cggcacccct atcacagagg
     4921 ctcagcggag cgccagggag cgcggcgtag agccgggcgt gctgccgtgc gccgggttcg
     4981 ggaccaccgg ggcggggaga gatattcggg attcggggcc gaggggcccc ggtcgccgga
     5041 ttccttctgg aggtgcccca ccgtgagcgc gacgcttccc tctcgtacgg gaaaggcccc
     5101 gggagcctgg ccgttgctgg gccacgcatg gcaactccac gcgcggccac tggagttcct
     5161 gtcctcgctc cccgcccacg gcgacctcgt gcgcatcggg atggggccct ggccggcgta
     5221 tgtggtctgc gaaccggacg cggcccaccg gatgctcacc gactcccgca ccttcgacaa
     5281 gggcggcccc ttcttcgaca aggcccgggg tcttttcggc agcagcctcc ccatggccgg
     5341 ctggcaggaa caccgctggc agcgccgcca gatgcagccg gccttccaga gcgaccggat
     5401 cgagcggtac gccctggtca tgggcgagga ggtggaccgg atgaccggcc gttggcgggc
     5461 cggccaacgc ctggacgtga ccgccgcgct gaccaccctg accctgcgca tcgtcacccg
     5521 cagtgtgctc gccgccgagg cgcaggacga ggccgtcgcc gaggtgcagg agagtctgca
     5581 caccgtgatc gacggcatct accagcgggt gatgctgccg ctcggcccgc tctaccggct
     5641 gcccaccccc gccaaccgcc gttaccgcca tgcctgtgac cggctgcacc gcgccatcga
     5701 cggcatcatc gcggcgcgcc gggcggcacc cggagggaac gatctggtct ccatgctgct
     5761 caccgcggtc aacgacgaca ccggcgagcc gatgtccgat gtggacatca gggaccagct
     5821 catggtcatg atcggcgcgg gcttcgagac caccgccaac agtctcgcgt tcgccctgtg
     5881 gctgctgagt cagcaccccg aggccgaggc ccgggtacac gacgaggtcg accggacgct
     5941 cgcgggccgc accgccacca cggccgacct cgacggtctg acgtacaccc gtcgggtcgt
     6001 caacgaggtc ctgcggatgt atccggcggg ctggttcttc acccgtgtca ccaccaccga
     6061 caccaccctc gccggacggc acctgcccaa gggcaccgcg ctgctctaca gcgcctacct
     6121 cctccaccac cgcccggaac tgttccccga accgggccgc ttcgacccgg accgctgggc
     6181 cgcgcaggcg gcggagtccc tcccccgggg cgcgcacgtg ccgttcggcg gcggcaaccg
     6241 caagtgcatc ggcgaccagt tcgccctcat cgagatgacg ttggccctcg ccacggtctg
     6301 cacgcgctgg cgtctgcgcc ccgatcccgg cagcaccatg accgtccagg tccgcggcac
     6361 cctcggcccc ggaccgctcc ccatgacctg cgagccccgc ggcaggaagt ccgccgacac
     6421 ctgagccccg gcggaagcgg aacgggaacc accattgatc cactgccgtc tctcaacccg
     6481 tgatcgcagc gcgacgcggc ggcgggagat cccgggcctg cggctcgccg gggcggaggt
     6541 gctgcctgtg cgggggccga ccagcgggat gcgcgtgcgg tccggggcgc ccggggacgc
     6601 ctggcgcacg atgtccgtcg ccgccctggc ccaggcaccg gacaggcggc gcaccgaggc
     6661 gtggctgctc gccttcgtgg tggcgatcac gctgggcggc cacgccgcga ccggactggc
     6721 gatgaagggc cgactgcccg cgggattcgg cacgttcgcc ggagccgtcg ccctgttcgc
     6781 gctggtcccg catctggtcg tacgacgctg ggcggcgcgc gccgacccgc tgctgctgcc
     6841 gctcgccctg ttgctcaccg gcctcggtct ggtactcctg cagcgcctgg acgtgacgta
     6901 cctcgccgaa ccacgtctgc acatggtccc ggcgggccgc gggcagctgg tgtggacgac
     6961 ggtcggagtg gcctcctgcg gcggcctgct gatcgcgctg cgcgatcacc gaaggctcca
     7021 gcgttacatc tacttgatga tggccgtcgc cctgatcctt ctggcggcgc ccgcgttctt
     7081 cagcgccgac cagttcggcg ccaaacgctg gatcatgctg gggccgctgt ccgtgcagcc
     7141 gggcgagttc gtaaagatca tgatcgcggt gttcttcgcg ggctacctca ccgtcaaccg
     7201 cgacgcgctg gccctgtcgg gccgccgctt cctcggcatg cgactgccgc ccggccgtca
     7261 gctcggcccg atcgtggcga tctgggtgct cagcctcctg gtgctggtct tcgagcgcga
     7321 cctcggcacc tccctgatct tcttcggcct cttcgtgatc atgctctatc tggccacgga
     7381 gcggacgagc tgggtggtgt gcggcctgtt gctggccgtg gtcggcgccg cggtggtcgg
     7441 ctccctcgaa ccgcatgtgc acggccgcgt ggaagcctgg ctgcacccga tggacgcctt
     7501 caccccggca ggtcaaaagg cgcacctgtc aagccagttg ggtcaggcgc tgttcagttt
     7561 cggcagcggc ggcatgaccg ggagcgggct cgggcagggc cacccggaac tcgtgggctt
     7621 cgccgggaac agcgacttca tcctcaccac cgtcggcgag gagctgggcc tggccggggt
     7681 gatggcggta ctgctcctgt acggcctcct cgcccagcgg ggcctgcaca tcgcgatgct
     7741 cgcccgcgat ccgttcggca aactcctcgc caccggcctg gccggcgcac tggtgctcca
     7801 ggtgttcgtg gtgaccggcg gtgtcaccgg tctgatcccg ctgaccggca aggccttgcc
     7861 cttcctcgcg aagggcggct cctccatggt cgccaactgg ctgatggtgg gcctcctgat
     7921 ccgcatcagc gactccgcgc ggcgccgcca cgagcccgac ccgcaccggc cctgaacgcc
     7981 cccggtgcgg gtcgggcagt cgcctcgcgc cgatcggaac catgaggtgt gcatgccgcg
     8041 tccacccctg tggtcaccac ccgtggcctc gctcaaccgc cgtccccagg gggaaacacc
     8101 atggtcgatc cgggtagcac gcccgcaccc agccaacgcc gcaggagagg gggatgcctt
     8161 ccggcactcg tggttctcct ggtgatcctg ggcctcggct tcggggcgtc caaactcttc
     8221 ggaggcggga gcgacaagtc cgggtcgtcc cactcctcct cgtccgcctc gcacgacagc
     8281 ggtgagtgga aggtgggcga ctgcggcggc cccgaccccg atgacgcgcc gaacggttac
     8341 aaggcgttcg gctgcggcga ctcgggcgcc accttcaagg ccctcgacat ccaggccgcc
     8401 agtttcatgc cggactccat ccagtgcccc gccggtacgg acctcatcat ccaggtgagc
     8461 atcagctacg gcagcagcaa gagcaaaggc ggcggcatcc cctccaagac ggtgtgcgga
     8521 cgcaacctct cggccgacca cccgggtgac cccggcgccg gcggcggcca gttggtcaag
     8581 ggtgactgcg tcaccgacac cgcgaaggag gtttcctgcg cctccgcggg ctcgggcgcc
     8641 tacaaggtgc tcggcctgac caaggagacc tcgcagtgcc cgtccgggac caccgagccc
     8701 atgcgtctga ccctcgccat cggcaggccc tacgacgtga tctgcgccgc gaagcagtag
     8761 cgcgggcgtc cgggccgccc gcgtctacgt caggcgtagg ggcagcgaga gcaggccgcg
     8821 gtggcggggg ttggcctgcc accgtgcctc gtggtcctcg ctcagccgca ggccggggta
     8881 gcgggtcagc agctgggtga acgcgatctc ggcctgcagc cgggccagcg gcgcgcccag
     8941 acagtgatgg atgccatggc cgaaggcgag gtgcctggcg gcgtcctcgc ggttgatgtc
     9001 gaagcggtcg gggtccgcga acacctcggg gtcgcggttg gcgcccagca aggagatctg
     9061 cacgaactcg ccctccccga acaccgcttc accgacctcg accggctcgg ccgcgtaccg
     9121 caacgaggcc agggccgagg gcgattcgta gcgcaggatc tcctcgaccg ctcccggcac
     9181 gagcgtcatg tcggctcgca ggagggcgag ttgatcgggg tgggtcagca gggtgtggac
     9241 gccgttggcg atcaggttga ccgtggtctg atggcccgcg atcaccaaca ggaaggccat
     9301 cgaggtgatc tcgtcctcgc tgagcgcctc ctccccctcc gcgccggcct cgaccagcgc
     9361 ggaaagcagc ccgtcgtcgg gctgttcgcg cttgagggcg agcagcgccc ggaggtagcc
     9421 gagcatggac tcggcggtga acaccgacac ctcgccgtcg ccctgaccac cgtcgagggt
     9481 gttcccgcgc acctggaggg tctcgtggtc ggcgtccgag gcaccgaaga ggtcgaacac
     9541 gacggccagg ggcaggggca gcgcgaactc gctgatcagc tcgacctcgt cgcgcccttc
     9601 ccatgcgtcc aggagtcccg ccacatgggc ctcgatcgcg ggccgcaggg ccgcggtacg
     9661 gcgtgtggtg aacgccttct gcacaagctt gcgcagccgg gtgtggtgcg gtggatcgct
     9721 gttgagcatg tggctgaaca gagcgctgcc ggggccctgg gtgagcccga catgccgccc
     9781 gaacctctcc accgccccgc ccttggagag ccgttggtcg gccagcaggt ccttcgcgtc
     9841 ggcgtacgag gtgacgaccc atccctcgac cggggcgggc ccggggtagc gggcccggcg
     9901 cgccgcgccc tcctggcgcc actcgcggta ggtggcgtgg gggtggtcga agaacgccgg
     9961 gtcgagggac tggatgccgg gctcggcgga tgccgcggtc tcagacatga cgaaccttgc
    10021 tcctgtggcc tatgtggacg gtcttcacac cgagcagccc caccagcggg acgtcggcgg
    10081 ttcgctggcc cggagccacc acaagtccgg tccgacgtat gtggtccagc aggagttcgg
    10141 cgagcggcat caccatgtga cggccccagc agcgctccga gacatggccg aacggcatgt
    10201 agccgggggt gttgtcgggg tcgagtcctg cccagcgttc gggccggaac tcgttcggcg
    10261 cgtcccacag ggcggggtcg cgatgggtga ggagcggcag catcagcagg tcgtccccgt
    10321 ctccgatgcg gtcgtcgacg gccgggtatt ccggtgaccg gttccgcagc aggttccacg
    10381 acgggggcag cagccgcatc gcctcgaaga ggatgtcgcg gttggacgcg ccgtcgtcga
    10441 agggcgagcc gagccacagg gcgttggcta cgagcgtgga gaccgtgaag cagaccgggg
    10501 cggccgcacg gcggtagatg cccatcgcat agcgccggtc gtcgtaggtc cgggcctcgg
    10561 cgaacaggtt ggccagatgg gtcagtcggg gcccgggggc gggccggcgg ggcagggcgg
    10621 cccccgccac gatggtggtc caggtgagcc tggggtcgat ctccagggtg cgggacatga
    10681 ggatgcgcaa ccggtacggg tcgtcgcgca ggacgaggtc gctcaggaac cggtgcccgg
    10741 tgatcggcca gggcccggac agatcggtcg acgcgggcag cgggtcgggc tgctcgagcg
    10801 cggcgcggac gtccttgccg atcgtgcgca tcaccgacga ggcctccgcc ttggagatcg
    10861 accggccgtg caggggcttg aaggtgggcc gctcggtctc cgtcgcccgt cgcgcggcca
    10921 ggatgcggtc ggagagttcc gcgcccgcga tgccgatggt gtcgggttca agacggacga
    10981 ggtccttgcc gaggtgttcg tcgagcaggg cctgcaggcg aggggcgaga accgtggtgc
    11041 ggcgactggt acgggtcatg gcggatggca tacggagcgc tccggaaatg aaaatgcgga
    11101 gggcccgcac acgcgactga ccgaaattca gtcggcctgc ctcgtgtgcg ggcccaggat
    11161 tggccttcgg cttagtacca gaagtaccag gcggcctgct tcaggctcgg ctcgctcttc
    11221 ttggcacgca gggcggcaat aatcttcgac atgattaatc ccttcctctc ggtgatatcc
    11281 ggatgtgaac caccggacgg atgcccttcc attcacacac ctggggtgtg ttcatttcca
    11341 gtcaccggcc gctgagggga agtgaagcgg gccacggcga gcgttgtcaa tggttccgct
    11401 tttcttcttt cctgtgagtc ctggcgttca agtacaaccg ctcgaaacat gcattgtggc
    11461 ggtacgaaaa gaagtgcccg aacggtcatg ggcgattgcc cggaaatacc tttcgacgct
    11521 catacccgcc tgctatcaag ggaaatgggt acgctgtggt tcccgccgtc ggctgtcgcg
    11581 cgagtgagaa agtcccgtga gttgcccggt ctgctcgtcc cgccgctacc cctgccgggg
    11641 aggtctgact ccgggcagcg ccccgtcgcc cggctgtccg ctgagcggtg aggagcgggc
    11701 gctgcgcgtc cagcggcgcg aacggttccg cgaagtcagg tcccggcccg agtggaacca
    11761 gggccgggcg cgtgggcggc gcagccgggt cggcctgctc gcctgggcgg tgctcgcgct
    11821 gttgctcctc gccctcttcc tgctctgagc cctcttcccg ctttgacgcc cgcgcctcgg
    11881 cggtgccctt gtggccacgc tccggcggcg gctccacccg actccgggcg cggggccgcc
    11941 ggccgaaccc cttattgtcg ggcgggccac gggcgcccgt ggcccgccgg gcgagcacct
    12001 tcgcccggcc cgcccgaccc aggagtgtgc gacgacatga cccgcaaccg agccgacgcg
    12061 accgtggccg aacgattcct caccgcgttc gccgcacacg actgggaggc gctgcacgcg
    12121 ctcttctccg ccgacctggc ctggagcatg cccggcgacg gcaccatctc ggggacggtg
    12181 cacggcgcgg acgcagccgt cgaccgggcg cggaagatcg ccggccgggg cctggccacc
    12241 gagttgcgcc acatcctgac cggcgtgcac ggggtcgccc tctccctgca caacaccgcc
    12301 gaggacgccg acggccgtgc gctcgacgag cacctggcga ccgtgctgac cattcgcgac
    12361 ggcaaggtct gcgccatcga cagctatgtg tccgacgtgg acggcatgag cgccttcttc
    12421 agctagccca tggccggtgg gcacacgccg gctcgaccgc acatccgggg gaaccgtgaa
    12481 cgtcagcagt gaacaacacc cgcacaacgc acggcagttg caggccggtc aggtggtcgc
    12541 gatcggctgg ctgctgtgcg gcgccgcgct cgtcgaacgc gttccacgct tcgcctcagg
    12601 gcatcggtac ctgctgtgcc accactcgtc ggtcctcgac cgactcacgc tcacagccct
    12661 cgctctggta ctggcggcgg gggtggtcgc cctggccggc gcgatcatga tgcaggcgaa
    12721 gaacccccac cgggtggcct tccccgcggt gtgcctcgtc gtcgtggccg ctctcctcgt
    12781 cgcggcggac ggggtcgacg cccatggaga gaacctggcc acacagctgt cggccacacc
    12841 gttcacggcg ggcgcgtgtg actacatccc gcaggactat gtcgccacac cgggctggtt
    12901 cttctggtag ggcacagcca catgggccgg tgctacatgg acgggtgcta catggacggg
    12961 tgccacacgg gcggcgccgc agtcgtccgg cgtccggtcg cgagtcaccc ggccagcgcg
    13021 gcaaggagca tcggcaggga acggtgcaac tccctctccc agtagggcca tgcatgggtt
    13081 ccgggcccgt agaagtcggt gagcaccgga ctgccgaggg cgcccaaccg gtcggcgagg
    13141 gcccggttct gccgctcgaa gtaggcctcg ttcgggtcct tggccccggc cggatcgtac
    13201 gggcccgcct caccgttccc gcaggacagg aagaggggga gcccgcgcag tgcgctcgcc
    13261 cgtaccgtgg ggtcgtgcgc ggcccacacc gtacgttggc gcacgggatc accccagacg
    13321 gcgtacgggt ccacgccctg cgtgcggtcg aggttcagga accagtcggg gccgggtccg
    13381 ccgggcacct ggagcagcgg gtgcacggtg ccgctgaacg aggcgacggc ccggaacagg
    13441 cccgggtggc cggccgcgta cgagagcgcg ccgaaaccgc ccatcgagag accggcggcg
    13501 acgcgtcggc cgcccgcgcc gtagccgcgc tcgacgatct gacggacctc ggtggtgtgg
    13561 aaggtctccc agcgaggtgc gccgcccctg ccgtagttcc accagtcgct gtaccagccc
    13621 gccgcgccgg cctccggcat caccaccaac acccgccgca gggaagccag ttgggccaca
    13681 tcgctgtacg tcatccagtc ggtgtaccca ccgcagcagc cgtgcagcaa ccacagggac
    13741 ggccagtcgt gccgccccgg cgaccagccg tccggagtga gcaggcgtac atgggcggtg
    13801 gtgcccaggg ccggggaatc gatggtgagg tcgaggcggt tgggggcgat ccgttgctcc
    13861 gcgacgaccc gcgcgccgtc gtcggcccgg acgaaccggt cccgcgcgtg gcccgtgccc
    13921 gcgccgaacc cggcggccag cagggcgacc aggatcgcga caacgcctgt gctgaccggt
    13981 acgcgacgca tcccgccccc tttgtgtgag ccccgggccc ggtgcggaac accgcgccac
    14041 tcggcgaccg atggccccgc cggtctacca gccgcgtccc ttcgcgcgcg agaggcgctc
    14101 cccggccacc cccatgtggg ttcaccacat gggggccgca cccatggcgt gtcctgccgc
    14161 tggggccgca ccggctcacc cgtacggctc tcagagcgac agctgggaca cctcgctgct
    14221 cagcctcggc gccggaaccg gtcgttccga gcgcggcctc ggcggcacgg ccggagcgtc
    14281 ccgggcgatc gaggtgatga gctcgtgcag ctgctccgcg tagcggtgga tgttcttgtg
    14341 cgcgatcgcc gtgtccgggt agcggatggc cagttgcagc ccgccgtgca gccgggtgaa
    14401 ccacgcgcac acctggtcgc cgtaggagac ccggagcagc gcggacgccc ggagctcgtc
    14461 ccactgccgg gccccgggga tgtcccgggc gtccacgaac gacacgatcg agtagaggtc
    14521 gggggacgtc gggcggaagt ccgagccgag gagccgcagc acccgtgcga tcggcaggtg
    14581 ggcgagcgcc ttgttggccc gcagcgcgcc gtggaccatc ttcagggcgt cgtcgaaccc
    14641 ccgcgcctgt gccaccggga tctcgatggg cgccccgccg acgtaccacc ccaccgaatc
    14701 agcccaccgg gacttcgctc gggtgtgcag cggcaccacc gtgcggtaga ccggctcgcc
    14761 cccgatgtcg tggacgatga ggctggtcgc cgccagaatg ccgacctgcc cgccgccgaa
    14821 cggccggcag tacgccgaga aggcggcggc gtccgcgtcg tccacgagca tcttgtacag
    14881 gagcttctgc tcgggcagtc ccccgccggg ttcgagcccg aggtccaccg ggaaggccgg
    14941 cagcctgccg tcgcaccggg tgatgaactc ccgccagcgc gccacgatcg cgtgggtgtc
    15001 gtcgacctgg tccgcgctgg cccgctcgat ctcgcagaag tcgacatagc tgccgaccgg
    15061 tgccgtctcc tcggtacgcc cttcggcgcg cgccgagtac agctcatgga tctcggcggg
    15121 gatgcgctgg atcgagtacg cgtcgacgtt gctgtggtcg aaggccatgt agacgctggt
    15181 ggattcgggc ctgacgaccg ccgtgtacag gaagttcggc cagcccaggg cgtccgcctc
    15241 cacatcgaaa cgatcctgga ggtggtggct cagctcctcc gcgtcgggga agtcacccac
    15301 gacctcgcgc cggagcgcca ccgcgtcggg cgcggcggtg aagcggcgca tctcgtcgtc
    15361 gacccagcgg aagccgctgc gcagcgtctc gtgccgcagg gtccaggtcc gcagggccgc
    15421 ttccaggacg tccaggtcga ccggccctag gatgtcgaag gcggcgccca gccaggtcgg
    15481 cacgaacagg ccgtcctggc gcacggaccg agcggtcctg atgtgtgatt cctgcacata
    15541 ggcggggggc cgggagtcgt cgggctggct ggtcgcggcc tcgaccatgg cgggatccag
    15601 actccactcc accagccgtc cgggacggac ctcgcagccg tgaatgtcgg tgattcgcac
    15661 gggagttgtc cattcacaag ctgtcgggga acacgggcga gcggcgggcc gcgggtgctg
    15721 gtacggctgc gcgggaacgc ccgccgcggc cggccctgcg gagcacctgg cggcagtcgg
    15781 ccggacaggg cgagcggccc ggccgggcgc gtacggcccg atggccccgg acacggcgcg
    15841 cggcgcggca gacgaccgct gccccggtcc ggccctcaca ccccgagtgc tcccctgcgg
    15901 ggcaggccga gccggccgga tcgcacggct gccccggcct cggtgccaca acgcccctca
    15961 gcggggcacc cgttggagag ggcgtcgggc gagtcgcggc cgccgcgcac cgcagcccaa
    16021 gaaatacggt catgtggtga ccaacgcggg acaggcgctc ccgggcacgc aaaaccaccc
    16081 catcgagtcg tttgcgccga ccctcgcgtc ctcgcgcccc cgaagggatc acactcccgc
    16141 cccgcggccc atgaggcttt gcccggtccc caactccacc tgaaacacac cgatttgaag
    16201 ctcgcgcgac ccggaagagg caggcagcgg ggcgcggtgg gaagcggacg ggccgcgcgt
    16261 cagcccgtcg cggcgggcgg cgtgttcggc accgacagcg gggcgggctc ggccgtggac
    16321 ggcttggtcg ccggcttcgc ctgcgcgagc tcctccttga ccatggcgga gatctccttc
    16381 aggatcgccg ccacctccgc cttggcctcg gcgacgtccg ccgcggcgtc cttcttctcg
    16441 tcggcgatca tctggttgat gtccttcatc gtcgccgcca gctcggcctt gacgccggcg
    16501 acgtcgtcgt caccggcccg gccgcccatc gactcgcctc ccgtcccggg gacggatacg
    16561 gccggcgcct gtccggcggc gtaggcaggt gctgcggtac ctgcggcgag ggcgccgcac
    16621 agggcgatcg cggcgacggt ggtactacgg cgcatgatcg cgctcctcat cagatcgacg
    16681 gcatccggtt cactccactc tcgatccact gttcgccacc ttcggatgga gggccacccg
    16741 ggccttccga acgagtgagc ccggtctgac gctccgtcgg ggggtgccgc acactatgcg
    16801 gcggccgtca tggaggatcg ggccatgggt gaacgtgtgg aacgggtcga cgagcaggat
    16861 cgtgtcctcg gcgtcgtcga gcggggcgag gccgtgcgcg agggctggct gtaccggatg
    16921 gccatggtgc tgtgccgtga tgagcggggc cgctgcctgg tgcaccggcg cccggagggc
    16981 gtctcacgct ttccgggcga gtacagctgg ctggtggcgg gggcggtggg tgtgggcgag
    17041 ccctacgcgg acgccgcacg ccgggagctc cgcgaggagc tcggggtgga cgctccggtg
    17101 cgtccgctct tcaagttcct gtgcgacggg gagctcggac cgtactggtt cgcggtgtac
    17161 gaggccgtcg tggaggaggc ggacgtcgtg gcggacgcgt cggaggtcgc ctggcacggc
    17221 tggctgaccg acgacgagtt gagggcggcc atggcgagct ggaagttcgt ctcggacagc
    17281 cgggacgcct atacccgcta tctcgccctc ggctcgtcgg gccaggactc aggagcggtt
    17341 gacccggccg gccaccgcgt ggccgatgag taggtaaacc acggcgggca gaccgtagtt
    17401 gacgatcgtg cgccaggtgt cgtccctgat ggtgaacatg tcgcgcgacc agcccgagag
    17461 ccagtccgcc gcgtggcgca cccacgacac gatgtcgttg gccgtgttgg cgttcaccag
    17521 gaagaaggcg atccagagga tcaggatcag ggccatgaca tcgacgatga cgagtatgcc
    17581 ggtggctgcg gggttaccgc cgtagcgcct ggacatgtcc aactccttgt ctgtaccgat
    17641 gggttgaggt gccgatccgg ccgaccgtga cgtgccccgg gggcgccacg ggggcgcccg
    17701 ccgggacacg ggggatgtcg gtcctcacag gctgagcagg cgttccgcga gcctgcggta
    17761 ttcgcgcagg gccatccgga ggtcctcggt ggccgaaccg ccggacgcgt cctgccagga
    17821 cgcgcgcagc gtgccgcgcc gctgcccgag ggtctcgatg atccgctcgg tcagggcgtc
    17881 gaccgcggag gccgcttcct cgaccgccgc gcggggttcg tccacgaacc cgccgaccgc
    17941 gtggtgcagc ctgagctgca gcttctcccg ctcgtggggc ggcagtacgg caccgtcgtc
    18001 gacagcgccg gactcggccc cggtccgccg cccggcctgc tcggggacgc gcccctcggc
    18061 cgcgggctgt tccgccacgg gatgcccgga cagcgaccgt tcggacacgg gctgcccggc
    18121 tgcgggctgc ccggtgaggt gcttcccggt cccgggctgg tcgggaaggg cctggtcggg
    18181 ggtggcggta cgtccggtca cggactggtc gggggtggcg gtgcgcccgg ccacggactg
    18241 gtcgggggcc gcccgttcgg ggacgtcacg gccggtcaac ggctctccgg cggcggcccg
    18301 gtcggggacg gcacccccac tcaggggctg atcggcggcg gccccggcgg gaacatcgcg
    18361 tgcgatgccg ggctgatgag tgcccggctg ctcggggacg tcgtgccccg agacgagttt
    18421 gtcggccagg ggctgatcgg atgcggaacg ctcgggcttg gtcatgactg gctccctcgg
    18481 gcggtgtcgt cgtggtgcgt gccgctgtgg gacgcgtgcc ggccgccgcg cactccgagg
    18541 cgcccggcct tgtcaccgcg gcgttccccg gtcagtacgg cgaagaactc gtgggcctgc
    18601 acgagcgtct cgcgcagttc ttccgtgctg ggcctgcgcc cgtcggcgcc ttgggcgacg
    18661 ccacggatcc ggcggtagct gtccaggtgc tgggggtggt gcaccgagag cgcggccagt
    18721 tgctcgtcgg acgagccgct cgggaaaccg cgttcgttcg cgagccggcc gagcagcgcc
    18781 tcggcctcgg ccaccgcgcg ggtgggcgat tccacgaact cctcctggac acgggcccat
    18841 tgggccgcgt accggctgcg ctcctcggcg ctcggggggt cgaccttcag gctgccgtac
    18901 cggcggaccc gctcgtcgag gtccttctcc gcggccttca catctccgtg gtgctcggcc
    18961 acggtccgct cgtactcggg tccgaaccgg ctgcgcaggc cttggccccg ccgcgctacg
    19021 aacatgccga tgaccaccgc cagaacaacg atcaccacga tcgctatcag gatgatgacg
    19081 acaccactgg acatggcctg ccttcccgtt ggagaacggc cccgcactac gggctgtcct
    19141 ccaccgtgta gacgcgaaac ggccgaataa acgcgccgtc aagggacgtg tcccgcgact
    19201 tccgcacggc gggccgttca ccccatcggg tcacgcaatt ttcctccggg ccggaacacg
    19261 gagacgctgc agaggaacaa acccccacaa actggaggaa aatcgtgcgt atccgtaccg
    19321 cactcgccgc aactgtcctg gccgccactg ccgtcatcgg cacggcgggt gccgcggcag
    19381 ccgaccccaa cccgccggtg gtcggcacgg cccaggactc ccccggcgtc ctgtccggcg
    19441 acgtcatcca ggttccggtc accgtccccg tcaacgcgtg cggcgacacc atcgacctca
    19501 tcgggctgct caacccggcg gccggcaaca cctgcgtgaa ccactgacgc accggctgcg
    19561 cacctgactt cgccccggaa cggcaccagg gttccggggc gaagccgcgt tccccacacc
    19621 cgcaccgctc ggcgaagaac cgggccgctg cggaatacag cccggttcac ctcgcgtcgg
    19681 acgtgcatcg ccgccgtgtc cggagcagac tcgccctcgc taggggggcc tgcgaagaac
    19741 agaacgaaca ggaaagcagc gtcatgtcga ctgccagcca caccgagcac gccgaacaca
    19801 cccatgaaca cggcaccggc tgcggccatg tggccgtgcc ccacgcagac catgtcgact
    19861 atgtgcacga cggccatctc caccggtccc acgacggcca caccgacgag tgcgagccgg
    19921 gcggccacac cgtgcacgag gaccacaccc atcgccacca ggcgggctgt ggacatgttt
    19981 ccgtaccgca cggcgaccat gtcgactacg tccacgacgg ccaccgtcac gccgaccacg
    20041 acggccactg ggacgaccac tgagcgtcgg ccgcccctga acacggccgc atcgactccg
    20101 gcgcgatccc cgttcggtcc gcggcaggtc agtccgcggc cggccagtcg gccggaatcc
    20161 ccctcgcccc cgacggcggc gatccgcccg tccgggcgag ggggccctca tgggtgagcg
    20221 tctgtactct cgcccgcgca ctcgccagca actcccttgc cgtggccagg agttcggctt
    20281 cgacgatcgg tctcggcgcg ggatccggcg ccggtttcgc cgcctcgcgg atggtgaggg
    20341 cgaggtgggc ggagaggccg tcctcaccgc tggcgcggtg cggggcgccg cgcggtacgt
    20401 acaggacgtc acccgcaccg atgacggtgc acagggcggg cgcagccgga gtccggaccg
    20461 cgcccggacg tccatcgccg tcggccgggg cctcgtacac cgtccactcc ttgcggccgg
    20521 cgagctgtac gacgaggaca tcggcgtcgt cgcagtgcac atcgcggcca ctgcgcccca
    20581 ccgtcgtcgc gaagcagaac gcctccgtct cacggcccag gtcctgggag aggagggccg
    20641 tcagggcgcc ggccgaggcg ttccaccggc cgagtcgggg cagcaggagc gtggccccct
    20701 ccgcgagcag atgcatgatc cgttccggat cggcgaatcc ttcctcggtc ccgtgggccg
    20761 cgccggcggc ggcaccgagc tccgccgccg gtacgacctc gccctcccgc accagctcga
    20821 cgtacggcgc gcgcatcaga ccgccgtcga gccctcccgt caactcccgt agtgtgggca
    20881 cctcttgagg cagggatgga ggcgtgaaca cacgcggccg gcccaggcgg cacgtctcga
    20941 agaacgaccc gggctcgccc agcaggcggt caagcactcc ccaacgcatc gtctctcccc
    21001 aggtcggggg cggtccggcg ccgcccctag ccgaacctac gggagcgatc acgcatatgc
    21061 cccgggacga tcgggcagcg taggcggtcg cgaagtcgcg gaatctgccc gggagatcat
    21121 tgacgggtcg gcgaacgcgt cgcacccgat cgttgacctc aagcacggtg gaggtcgtac
    21181 gttcctcgca tgagtatgga agccaccgcg tggacgcagc tccacaacgt catgaacgcc
    21241 cagcaggaca agcggccctt caaccgggcc acgctgcgcc gcatcgccgc cttcgcccgc
    21301 ccccaccggc gc
//
