LOCUS       NZ_BMUU01000001        21605 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence01, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000001
VERSION     NZ_BMUU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1270804)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 885409
            Orig. end                         :: 907014
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21605
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene"
                     /product="hserlactone"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="Autoind_synth"
                     /tool="antismash"
     cand_cluster    1..21605
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="Autoind_synth"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="hserlactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20624
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20624
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10624](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10624
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            568..1482
                     /db_xref="GeneID:96288821"
                     /locus_tag="IE233_RS03850"
                     /old_locus_tag="GCM10010326_08080"
     CDS             568..1482
                     /GO_component="GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523154.1"
                     /locus_tag="IE233_RS03850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08080"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_190026185.1"
                     /transl_table=11
                     /translation="MITRTWRALVQATGALTLTVGALTAGTGPAAAAPQPMGQCTTSSG
                     AVLAVDFSKWGGPVYRSCGTTPTTGYELLNQGGWRTTGTGHDGPAFICRIGYSGYQGGK
                     QFPPPSQEDCVLTPPASAYWSYWHADPGANTWEYSQLGAMLYKPKPGSVDLWIFGGTNV
                     EGTEGRPSVTPDQLRAHNAEPTGGAPQAPDATKKAPALPPGTDTGPAPEHPPVASSTPS
                     SSPSSATPSASASPSPSASASAGATPSPAATPTGGSKVVDAAPAGEAAHDTGSFAPVAI
                     TAGLVVLIGGAGAYAARRRRRSE"
     cand_cluster    949..21605
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    949..21605
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10948:11605](+)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10949..11605
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="2"
     gene            1487..2683
                     /db_xref="GeneID:96288822"
                     /locus_tag="IE233_RS03855"
                     /old_locus_tag="GCM10010326_08090"
     CDS             1487..2683
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036742.1"
                     /locus_tag="IE233_RS03855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08090"
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /protein_id="WP_267907158.1"
                     /transl_table=11
                     /translation="MPPTAVPRSAVSLARPGSDERRLPRTLHPMAWWVWALALATAVSR
                     TNNPLLLVLVLAVLGYVITMRRTEAPWARGFKYYLYLALSVVAIRVIFRALFATGITPH
                     DHFLFSLPHIPTPAWYAGIQLGGPVSLEALLSAAVDGLRLACMLCCIGAANTLANPKRA
                     LRVLPGSLYELGVAVTVSISVAPQLVQSVQRVHRARRLRAGRTKGLRALRGIVVPVLED
                     ALERSLRLAAAMDSRGYGRAGRATKGSRRLTGALLLLGMCGLCSGAYGLLDATAPKLLG
                     LPSMATGALLCVAGLRLGGRRVTRTSYRPDPWRFEEWAVAGCGVLSAVLLFTDVGFNAA
                     ELNPSIYPLSWPTLPMVPAAAILLAGAAGFLAPPPLPVTGARPTPGVPVRPSEKATAT"
     gene            2680..4353
                     /db_xref="GeneID:96288823"
                     /locus_tag="IE233_RS03860"
                     /old_locus_tag="GCM10010326_08100"
     CDS             2680..4353
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288823"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965690.1"
                     /locus_tag="IE233_RS03860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08100"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190026186.1"
                     /transl_table=11
                     /translation="MITFDHVTVQYDAAADPVLRDIDLTVEEGELCLVVGHTGVGKSTL
                     LGAVNGLVPHFTGGTLFGSVTVDGRDTAHHPPRELADVVGVVGQDPLDGFVTDTVEEEL
                     AYSMEQLAVPPETMRKRVEETLDLLGLADLRHRALHELSGGQQQRVAIGSVLTAHPRVL
                     VLDEPTSALDPTAAEEVLAAITRLVHDLGVTVLLAEHRLERVVQYADRVLYLPGDGRAV
                     SGAPADVFRTTTIAPPIVELGRHVGWRPLPLSVRDARRAAAPLRARLAATPVPSARPAI
                     TGAQQPSVLDARAVSVRYRGQALPAVREVDLELRGGETVALMGRNGSGKSSLLWALQGS
                     GQRTGGTVRVSHWPPPKSSPEGPARDPGSVSAAQARRLVGLVPQTPTDLLYLESVKQEL
                     DQSDAESAVGAGPSARTVLDRLAPGIDDGAHPRDLSEGQKLALVLAIQLCAAPGVVLLD
                     EPTRGLDYRAKAELTRICDELAAEGRAVVVSTHDVEFVARTADRVVVMAEGEIVADGPA
                     ADVVVSSPVFAPQVAKVLAPLPYLTVDQVRATEPGEGGRP"
     gene            4350..5195
                     /db_xref="GeneID:96288824"
                     /locus_tag="IE233_RS03865"
                     /old_locus_tag="GCM10010326_08110"
     CDS             4350..5195
                     /codon_start=1
                     /db_xref="GeneID:96288824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060842.1"
                     /locus_tag="IE233_RS03865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08110"
                     /product="ECF transporter S component"
                     /protein_id="WP_161252944.1"
                     /transl_table=11
                     /translation="MSGHVRLRTTAIRITPRAGVIIAMAAFVGVVAFFWPFVVAPGKFG
                     SSYAPPLIFGVLLVLVLCVVISEIAEGGINSKALAMLGVLSAVNAAIRPLGAGTAGIET
                     VFFILVLAGRVYGPGFGFTLGCTSLFASALITGGVGPWMPYQMFGCAFVGMLAGFLPRA
                     SGRLEILLLAVYGSLSGYLFGFLLNLSFWPFSLDPNSSIAYLPGLPFTEQWHRYLAFDL
                     ATSLGWDTGRAVTNFVCVVLAGPAVLTVFRRAARKARFQAPITFAPQRGTGADTPSVEA
                     "
     gene            5274..5756
                     /db_xref="GeneID:96288825"
                     /locus_tag="IE233_RS03870"
                     /old_locus_tag="GCM10010326_08120"
     CDS             5274..5756
                     /codon_start=1
                     /db_xref="GeneID:96288825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019985390.1"
                     /locus_tag="IE233_RS03870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08120"
                     /product="DUF4430 domain-containing protein"
                     /protein_id="WP_190026187.1"
                     /transl_table=11
                     /translation="MRQTVLRRTVLSTTAIGLALTATPAFACPAPNPNAPVVVTVTVKG
                     PNSTLFNGKVRTKGHDVTTTTGGAHKCDGTNGAKNPAPVPTPTAALDDAAHQRGFAWDG
                     AWYASFDDFSVDTIKNVSGGAAAYWNISVNGTPTPVGGCQFALKAGDKVAFTWTSL"
     gene            6149..6811
                     /db_xref="GeneID:96288826"
                     /locus_tag="IE233_RS03875"
                     /old_locus_tag="GCM10010326_08130"
     CDS             6149..6811
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288826"
                     /inference="COORDINATES: protein motif:HMM:NF024304.5"
                     /locus_tag="IE233_RS03875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08130"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_161252948.1"
                     /transl_table=11
                     /translation="MHSTARTAANRYPERVTYERDAVYAILDEALAVHVGFNTDLGPVV
                     IPTLHMRVDDQLLLHGSAFGRFITTAASGAPLCVTATLIDGVILGRASSHHSAAYRSAM
                     VFGTASPIEDERERADALAQVVESVIPGRLSGPHAARRPNTEEARYTACLTMPIEEFSM
                     KVRAGFARDEPKDDHVESWAGWIPLTTTPGIPVPDEITGDRFPAPTYDPSVHRFRQD"
     gene            7151..8419
                     /db_xref="GeneID:96288827"
                     /locus_tag="IE233_RS03880"
                     /old_locus_tag="GCM10010326_08140"
     CDS             7151..8419
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081245.1"
                     /locus_tag="IE233_RS03880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08140"
                     /product="sodium:proton antiporter"
                     /protein_id="WP_190026188.1"
                     /transl_table=11
                     /translation="MVPTLLATAVAALVRSLAALWLQRWNIGAPAFMVLAGFLLGLDTG
                     DTVESALNTHVAQHVCEIVLAFLLFIDATEIRGGRLWGTSPRLVARVLLVAMPLSLGAA
                     MLLGAWLFPHLPWAVLLIIACVVVPIDFAPAEHLVRDQRLSARVRSVLNIEGGYNDGII
                     SPVFLFALLLAGSASGVSTPVEALATALTQAGVAIAVGLALGAVMAWALDRAGRAGWMT
                     DQSRRIAVVLTPVVTYCAAVQLRGNGFVASFVCGIAFRYLHRVLTARAIRSIPRLPPAQ
                     PPARASTVLTHDFGLIEDVTALMTLTMWFVVGIATVVTPDLGLSWQAALFCLGALTLVR
                     VLPVLGSLTASPLPRADRVLLSLLGPRGTTSIVFGLIAYNQLPTGPGADTVLLTTVLCV
                     LGSVLLHGMGSDTVIRRLAPTPR"
     gene            complement(8463..9932)
                     /db_xref="GeneID:96288828"
                     /locus_tag="IE233_RS03885"
                     /old_locus_tag="GCM10010326_08150"
     CDS             complement(8463..9932)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288828"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009070113.1"
                     /locus_tag="IE233_RS03885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08150"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_190026189.1"
                     /transl_table=11
                     /translation="MNHQVVVAGAGPVGLWLAGELRRAGITVAVIEPRSERDSRSRALT
                     VHPRTIETFASRGAHHPFVSEGVPLPGGHFGALDSRLDFRRLPSPFPHTLALPQERTEA
                     LLEGQALALGAHILRGREVTGFTEHPDHIAVHTAGPHGPSTLQAAYLVGCDGARSTVRA
                     AAGIDFPGTPATVFGWLGDVVLDSPPVPGYSYFGPAGALMAVPLPGGVHRLVGITPRDL
                     TTTWPGDFGLDELRANVAAMAGTDFGLRDPVWLSRYGNATRLADQYRKGRVFLAGDAAH
                     QHFPAGGVGMNVGIQDAANLAWKLAATLNGWAPTGLLDTYHAERHPVGADLTAASRAQV
                     ALMTAFTPEGLDLRGLLARLITTLPDLNDHLAAQVSSLAVTYPPATPGDHPLTGTRAPD
                     LALGDTGLFALLGVDRHLLLDLTGSGRLTGYAGRGLHVHTATPHEPPAEFTDVRAVLVR
                     PDGHVAWASAERDEAALAGSLTAALATTHRK"
     gene            10001..10624
                     /db_xref="GeneID:96288829"
                     /locus_tag="IE233_RS03890"
                     /old_locus_tag="GCM10010326_08160"
     CDS             10001..10624
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288829"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432569.1"
                     /locus_tag="IE233_RS03890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08160"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_161252957.1"
                     /sec_met_domain="T1TS (E-value: 0.00039, bitscore: 16.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKQAGEDTAGQLTRAAVIDAALQVLGERGLDGLSTRAVADRLG
                     VRMNTVLWHVKTKARMLELMADAVLAGIRYDDLPDAPLARARELVGRYRHALLAHRDGA
                     ALVTGTYPAEPNTLRFADRLVDAFLEAGTDERQAAWTAWTVNYFTLGLTQEEQAEGEED
                     DARLAQAVGLGTHPALQRVLPHLRQNFDERFAFGLEAVLSRIPE"
     gene            10949..11605
                     /db_xref="GeneID:96288830"
                     /locus_tag="IE233_RS03895"
                     /old_locus_tag="GCM10010326_08170"
     CDS             10949..11605
                     /codon_start=1
                     /db_xref="GeneID:96288830"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012967.5"
                     /locus_tag="IE233_RS03895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08170"
                     /product="acyl-homoserine-lactone synthase"
                     /protein_id="WP_161252959.1"
                     /sec_met_domain="Autoind_synth (E-value: 3e-31, bitscore:
                     104.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSFAARDCTVLAGRAGEPRLSPALLEDMFRLRYEVFHRRLGWAV
                     DVDNGLERDEFDDLDPVYAIAVHRPSKAVVGCVRVLPTTGPNMLRDVTAFHAALQGRPA
                     PCSPHIWEASRFAIDPRVRPAPRLDPRGFQAVPRALLAAIGTYAAEHGVDQVVGLSGVT
                     IEAKFHASGVPTTRIGDAPCHIGSVLCTAYSFAVADLVALGEPASPQGTSGQLIH"
     gene            11738..12070
                     /db_xref="GeneID:96288831"
                     /locus_tag="IE233_RS03900"
                     /old_locus_tag="GCM10010326_08180"
     CDS             11738..12070
                     /codon_start=1
                     /db_xref="GeneID:96288831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519660.1"
                     /locus_tag="IE233_RS03900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08180"
                     /product="hypothetical protein"
                     /protein_id="WP_190026190.1"
                     /transl_table=11
                     /translation="MDDVLPLFAIFGGLAAVLAALVWLARHVRRRGIAGAGVAAALASW
                     EEAYRVTAHESHWEIKAQAERQFSVLSPDGHWPRAGEGNPRPTASRRRRDGKRLRRLVR
                     RRRPRG"
     gene            complement(12250..13551)
                     /db_xref="GeneID:96288832"
                     /locus_tag="IE233_RS03905"
                     /old_locus_tag="GCM10010326_08190"
     CDS             complement(12250..13551)
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700197.1"
                     /locus_tag="IE233_RS03905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08190"
                     /product="ion channel protein"
                     /protein_id="WP_161252961.1"
                     /transl_table=11
                     /translation="MTTPGDGASAAPAALPSVSARTLLPVVVPALAVGVGCSLLFLAIS
                     AVAERLEDVWWKDLPGALGIGGYSSLWMIAVLTLTGVLVGLVVWKAPGHAGPDPATLGL
                     GESEPLRAHVVPGLLVANVLMLAGGPSLGPENPIIAANAALAFWLGTRAVPKAPGRMWV
                     PLATAATLGALFGTPVAAALVVSEALAGKPLPVKGSLWDNLFGPLLAAAAGALTTTLLA
                     SPSFDLGLPPFGKPGWDDLLAAVVLACLAAALGMLAVCLFPYVHRAFGQLRHPMLMLPL
                     GGLVLGLLGALGGHLTLFKGLHEVGELAADPDGWSAGRFAVMAVVKLAALVIAASCGFR
                     GGRIFPAVFIGAAFGLCAHALVPAVNPSVSVSAGVLGMLLAITRQGWISLFTAAVLVAS
                     PAILALMCIASLPAWLLVTGRPQMQLKQDGSSLR"
     gene            13677..14201
                     /db_xref="GeneID:96288833"
                     /locus_tag="IE233_RS03910"
                     /old_locus_tag="GCM10010326_08200"
     CDS             13677..14201
                     /codon_start=1
                     /db_xref="GeneID:96288833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059589.1"
                     /locus_tag="IE233_RS03910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08200"
                     /product="hypothetical protein"
                     /protein_id="WP_161252962.1"
                     /transl_table=11
                     /translation="MTGQRTDGASSADPANTYLQSLGERLTADKCRMTASNWGEHPVVI
                     GSRSDRKARWFGTKVELFVFAAVVPGVDDAHLAEFTKWAMSYAQSCRSGLPGARNAMMV
                     LPALISGGVHTSAREWASRDARVLGTTVIGRPLTVEAAQGVSRVTMYRGGTVWGGMFTR
                     HVLEKASLYFP"
     regulatory      14411..14633
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            14805..17123
                     /db_xref="GeneID:96288834"
                     /gene="metE"
                     /locus_tag="IE233_RS03915"
                     /old_locus_tag="GCM10010326_08210"
     CDS             14805..17123
                     /EC_number="2.1.1.14"
                     /GO_function="GO:0003871 -
                     5-methyltetrahydropteroyltriglutamate-homocysteine
                     S-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288834"
                     /gene="metE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027494.1"
                     /locus_tag="IE233_RS03915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08210"
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="WP_190026191.1"
                     /transl_table=11
                     /translation="MTAQSAAAAAQATVYGYPRQGRNRELKKAIEGYWKGRVTADALRN
                     TAAELRQGNWRQLADAGIHEVPTGDFSFYDHVLDTTVMVGAIPTRHRSAVDADALDGYF
                     AMARGTQEVAPLEMTKWFDSNYHYLVPELGPDTVFAGDSSHQVGQLKEALALGLSARPV
                     LVGPVTYLLLAKPAPGVAADFEPLTLLDRLLPVYAEVLADLRAAGAEWVQLDEPALVQD
                     RTPAELNAAERAYRDLGALTDRPKLLVASYFARLGDALPVLAKAPVEGLALDFTESAAA
                     NLDALAAVGGLPGKRLVAGVVNGRNIWINDLQKSLSTLGTLLGLADRVDVAASSSLLHV
                     PLDATIERDIEPQILRWLAFAQQKTAEIVTLTKGISQGVDSIKAELAANRADLASRAAS
                     PITRDPAVRARAAAVTDADARRSQPYAERAAAQRAHLGLPLLPTTTIGSFPQTAELRTA
                     RADLRAGRIDTQGYEARIKNEIRDVISFQEETGIDVLVHGEPERNDMVQYFAEQLTGYL
                     ATQHGWVQSYGTRYVRPPVLAGDIARPEPMTVRWTAYAQSLTDRPVKGMLTGPVTMLAW
                     SFVRDDQPLGDTARQVALALRDEVNDLEANGTSVIQVDEPALRETLPLRAADRPGYLTW
                     ATEAFRLTTSGVRPDTQIHTHMCYAEFGDIVQAIDDLDADVISLEAARSHMQVAHELAA
                     HGYPREAGPGVYDIHSPRVPSTDEAADLLRTGLKAIPAERLWVNPDCGLKTRGWPETRA
                     SLENLVAAARTVRGELPAS"
     gene            complement(17210..17593)
                     /db_xref="GeneID:96288835"
                     /locus_tag="IE233_RS03920"
                     /old_locus_tag="GCM10010326_08220"
     CDS             complement(17210..17593)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288835"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735592.1"
                     /locus_tag="IE233_RS03920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08220"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_161247186.1"
                     /transl_table=11
                     /translation="MATSPTGADGGVVYRADCPSRPILDQIADKWSMMVMAVLDKPTRF
                     NEIKRRLEGVTQRVLTQTLRRLERNGMITRRVLPTSPVGVEYSLTPLGESLREPFGRLY
                     AWTVDNTDEIRAHQTAYDQRVQS"
     gene            17715..18548
                     /db_xref="GeneID:96288836"
                     /locus_tag="IE233_RS03925"
                     /old_locus_tag="GCM10010326_08230"
     CDS             17715..18548
                     /NRPS_PKS="Domain: ECH (11-224). E-value: 5.9e-37. Score:
                     119.2. Matches aSDomain:
                     nrpspksdomains_IE233_RS03925_ECH.1"
                     /codon_start=1
                     /db_xref="GeneID:96288836"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735593.1"
                     /locus_tag="IE233_RS03925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08230"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_161247184.1"
                     /transl_table=11
                     /translation="MTHDIYPTLRVSREDGIARVTLDNPPVNVLDVALMADLRHLLTAL
                     SSDGSLRVIVFESANPEFFIAHVDMSLIDTPDAFDQFAPDLPDGVNVFQALGELLRHQP
                     QVTIVKLAGMARGGGAEFVTAADMTFAAIGRAGIGQIEALMGIVPGGGGTQYLAGRVGR
                     NRALEAVLGADLFDAETAERYGWVNRAVPADELDDVVDRLARNIAALPEGVIAAAKRAI
                     VPEDLAEGLLREHDAWAAQFARPDAERLIRGGLAHGAQTRDGERDLEGLLRGLPG"
     aSDomain        17748..18386
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS03925_ECH.1"
                     /evalue="5.90E-37"
                     /label="IE233_RS03925_ECH.1"
                     /locus_tag="IE233_RS03925"
                     /protein_end="224"
                     /protein_start="11"
                     /score="119.2"
                     /tool="antismash"
                     /translation="SREDGIARVTLDNPPVNVLDVALMADLRHLLTALSSDGSLRVIVF
                     ESANPEFFIAHVDMSLIDTPDAFDQFAPDLPDGVNVFQALGELLRHQPQVTIVKLAGMA
                     RGGGAEFVTAADMTFAAIGRAGIGQIEALMGIVPGGGGTQYLAGRVGRNRALEAVLGAD
                     LFDAETAERYGWVNRAVPADELDDVVDRLARNIAALPEGVIAAAKRAIVP"
     gene            complement(19143..19964)
                     /db_xref="GeneID:96288837"
                     /locus_tag="IE233_RS03930"
                     /old_locus_tag="GCM10010326_08260"
     CDS             complement(19143..19964)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-170). E-value: 3e-11. Score:
                     35.5. Matches aSDomain:
                     nrpspksdomains_IE233_RS03930_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GeneID:96288837"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151883.1"
                     /locus_tag="IE233_RS03930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08260"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190026192.1"
                     /sec_met_domain="adh_short (E-value: 2.6e-32, bitscore:
                     108.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDYTNSTAVVTGASKGLGEAYARDLASRGAHLILVARSADALHT
                     LAGQIRKTHSVRVDVIAADLSDRRSPQAVVNTIEELGLNVDLLVNNAGMGSVGPFLGRP
                     LEPNFQSVDVNVTALIGLVHLLGTGMVERGRGGIINVASTAAFQPMPYQASYAATKAFV
                     LSFTEALAEEVRNTGVRVMAAHPGATATGFFDRTTASMDPKVTDTPVDVAARTLDDFAR
                     GRSISFPGRASNRAGVWASRLFPRTTVARVTGHLNRKAGLDDVSDLDPAAP"
     aSDomain        complement(19455..19943)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS03930_PKS_KR.1"
                     /evalue="3.00E-11"
                     /label="IE233_RS03930_PKS_KR.1"
                     /locus_tag="IE233_RS03930"
                     /protein_end="170"
                     /protein_start="7"
                     /score="35.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGASKGLGEAYARDLASRGAHLILVARSADALHTLAGQIRK
                     THSVRVDVIAADLSDRRSPQAVVNTIEELGLNVDLLVNNAGMGSVGPFLGRPLEPNFQS
                     VDVNVTALIGLVHLLGTGMVERGRGGIINVASTAAFQPMPYQASYAATKAFVLSFTEAL
                     "
     CDS_motif       complement(19848..19937)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE233_RS03930_0001"
                     /evalue="1.60E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE233_RS03930"
                     /protein_end="39"
                     /protein_start="9"
                     /score="20.8"
                     /tool="antismash"
                     /translation="VVTGASKGLGEAYARDLASRGAHLILVARS"
     gene            20168..20602
                     /db_xref="GeneID:96288838"
                     /locus_tag="IE233_RS03935"
                     /old_locus_tag="GCM10010326_08270"
     CDS             20168..20602
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288838"
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016910009.1"
                     /locus_tag="IE233_RS03935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_08270"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_161247180.1"
                     /transl_table=11
                     /translation="MTRDTLVAAVVANHEIFMRTSDRIGTVLAEHGLTPATAQALWSID
                     PAEAPPSMKELAGRLYCNAPNLSFVMNQLTGRGLVERSADPADRRSRVAALTEEGRRVR
                     SALIEATLALSPLARLDADDLHKLVSLLGKALEPTSGPRR"
ORIGIN
        1 gatggccgcc atggcgctcg acctggtcaa ggacgacaag tcgaaggccg ccgtcaccaa
       61 ggcactggcc tggatcgcca ccaagcagtt gtcggacggc ggcttcaagg gcgcgtcggg
      121 cgactcggtc aactccgcgg cgctcgccat ccagggcctg tccctggacg cggcgaagta
      181 cggggagcag atcaagaagg cccgcaagtt cctggccggc cagcagaaca gcgacggcgg
      241 cttcaacgtc gccgccgacg gccagcccgg ctcggacgtc cgcgcctcca cccaggcact
      301 cggcggtgcc gtcgggacct ccttcgggac gctgacgcga gacctgagcg gaaccaagcc
      361 acagcccacg accgcaccca ccggcggcac cacaccgcag atcgtcacgc ccggcggaga
      421 cgccgccgga acgccggcag gtggcggcag tctcgcctca accggcgctc aggcaacggg
      481 acttgccctc gccgcagctc tcctgtgcct ggcaggctgg cgcacggtcg tcgtagcccg
      541 ccgtcacagc accgagggag cgcagcggtg atcacgcgta cgtggcgggc actcgtccaa
      601 gcgactggtg ccctgacact caccgtcggc gcactcaccg ccggcaccgg gccggccgcc
      661 gccgcgccgc agcccatggg tcagtgcacc acctcgtcgg gggcggtcct cgccgtcgac
      721 ttcagcaagt ggggcggccc ggtctaccgc tcctgcggca cgaccccgac caccggttac
      781 gagctcctca accagggcgg ctggcgcacc acgggcaccg gccacgacgg cccggcgttc
      841 atctgccgca tcggctacag cggttaccag ggcggcaagc agttcccgcc gccctcgcag
      901 gaggactgcg tcctcacccc gcccgcctcc gcctactggt cgtactggca cgcggacccc
      961 ggcgcgaaca cctgggagta cagccagctc ggcgcgatgc tctacaagcc gaagccgggc
     1021 agcgtcgacc tgtggatctt cggcggcacc aatgtcgagg gcaccgaggg acggccgtcg
     1081 gtcacaccgg accaactgcg cgcccacaac gcggagccca ccggaggagc accgcaggca
     1141 ccggacgcca cgaagaaggc acccgcgctc ccacccggca ccgacaccgg accggccccc
     1201 gaacatccgc ccgtcgcatc cagcacaccg tcgagcagcc cgtcgagcgc gacaccgtcc
     1261 gcttcggcat caccgtctcc ctccgcctcc gcatcggccg gcgccacacc gagcccagcg
     1321 gccaccccta cgggcggctc gaaggttgtt gacgccgcgc cggccggtga agccgcccac
     1381 gacacgggat cgttcgcgcc ggtcgccatc accgccggcc tggtcgtcct gatcggcggc
     1441 gccggcgcgt acgcggccag gcgtcgcaga cggtcggagt agccgcgtgc ctcctaccgc
     1501 cgtcccacgc tcggccgtgt ccctcgcccg cccgggctcg gacgagcgcc gcctgccccg
     1561 cacgctgcac cccatggcct ggtgggtctg ggcgctggcc ctggccaccg ccgtcagccg
     1621 caccaacaac ccactgctgc tggtcctggt cctcgccgtc ctcggctacg tgatcaccat
     1681 gcgccgcacc gaggcaccct gggcacgcgg cttcaagtac tacctgtacc tggccctctc
     1741 ggtcgtcgcg atccgcgtga tcttccgcgc gctgttcgcc accggcatca ccccgcacga
     1801 ccacttcctc ttctcgctcc cccacatccc gacccccgcc tggtacgcgg gcatccagct
     1861 cggcggcccc gtctcgctgg aggccctgct ctcggcggcc gtggacgggc tgcgcctggc
     1921 ctgcatgctg tgctgcatcg gcgccgccaa caccctggcc aacccgaagc gcgcgctgcg
     1981 cgtgctgccc ggctccctct acgagctggg tgtcgcggtc accgtgtcga tcagcgtggc
     2041 ccctcaactg gtccagagcg tccagcgggt gcaccgcgcc cgccggctcc gcgcgggccg
     2101 caccaaggga ctgcgagcac tgcgcggcat cgtcgtcccc gttctcgaag acgccctgga
     2161 acgctcgctg cggctcgccg cggccatgga ctcgcgcgga tacggccggg ccgggcgggc
     2221 gacgaagggc tcgcgccggc tgaccggcgc cctgctcctg ctcggcatgt gcgggctgtg
     2281 ctcgggggcg tacgggctcc tcgacgccac ggcacccaag ctgctcggcc ttccctcgat
     2341 ggcgaccggc gcactcctgt gcgtagcggg actgaggctc ggcggccggc gcgtcacccg
     2401 gacctcgtac cgccccgatc cgtggcgctt cgaggagtgg gccgtggcgg gctgcggtgt
     2461 gctgtccgcg gtcctgctct tcaccgacgt cgggttcaac gcggccgaac tcaacccgtc
     2521 catctacccg ttgagctggc ccacgctgcc catggtcccg gccgccgcca ttctgctcgc
     2581 gggtgccgcc gggttcctcg cccctccgcc cctccccgtc accggggcgc ggccgacgcc
     2641 gggcgtgccc gtgcggccct ccgagaaagc caccgccacg tgatcacctt cgaccatgtc
     2701 accgtccagt acgacgcggc cgccgatccg gtgctgcgcg acatcgacct caccgtggag
     2761 gagggcgaac tctgcctggt cgtcggccac accggcgtcg gcaagtcgac ccttctcggc
     2821 gcggtgaacg ggctggtccc gcacttcacc ggcggcaccc tcttcggctc cgtcacggtg
     2881 gacggccgcg acaccgcgca ccacccgccc cgggagctgg ccgacgtggt cggtgtcgtg
     2941 gggcaggacc cgctcgacgg cttcgtgacc gacacggtgg aggaagaact cgcttattcc
     3001 atggagcagt tggcggttcc acccgagacg atgcgcaagc gcgtcgagga gaccctcgac
     3061 ctgctcggcc tggccgacct gcgccaccgc gccctgcacg agctgtcggg cggccagcaa
     3121 cagcgcgtcg ccatcggctc cgtcctcacc gcgcatcccc gtgtcctcgt cctcgacgaa
     3181 ccgacctccg cgctcgaccc gaccgccgcg gaagaggtcc tcgccgcgat cacccgcctc
     3241 gtccacgacc tcggcgtcac cgtgctgctc gccgaacacc gcctggaacg ggtggtccag
     3301 tacgcggacc gggtcctgta cctgcccggt gacggacgcg ccgtctccgg cgcccccgcg
     3361 gacgtcttcc gcacgaccac catcgcgccc ccgatcgtcg agctggggcg gcacgtcggc
     3421 tggcggccgc tgccgctgtc ggtacgtgac gcccgccgcg cggccgctcc cctgcgcgcc
     3481 cggctggccg cgacaccggt cccgtctgcc cgccccgcga tcaccggagc acagcagccg
     3541 tccgtgctcg acgcacgagc ggtgagcgtc cgctaccgcg gccaggcgtt gccggccgta
     3601 cgcgaggtcg acctggaact gcggggcggc gagacggtgg cgctcatggg ccgcaacggc
     3661 tccggcaagt cctcgctgct ctgggcgctc cagggctcgg gacagcgaac gggcgggacc
     3721 gtgcgggtga gccactggcc gccgccgaag agctcccccg agggaccggc ccgcgacccc
     3781 ggatcggtgt cggccgccca ggcccggcgg cttgtcggcc tggtccccca gactccgacc
     3841 gatctgctct acctggagag cgtcaagcag gaactcgacc agtccgacgc cgagtccgct
     3901 gtcggcgcgg gcccgtcggc acggaccgtc ctggatcgcc tggcgcccgg catcgacgac
     3961 ggcgcacacc cccgcgacct ctccgaagga cagaagctgg ccctggtcct ggccatccag
     4021 ctctgtgccg caccgggcgt cgtcctcctg gacgagccga cacgcggcct ggactaccgg
     4081 gccaaggccg aactgacgcg tatctgcgac gagttggcgg ccgaaggccg tgccgtggtg
     4141 gtgtcgaccc acgacgtcga gttcgtcgcc cgcaccgcgg accgcgtcgt ggtcatggcc
     4201 gagggggaga tcgtcgccga cgggcctgcc gccgacgtcg tcgtctcctc accggtgttc
     4261 gcaccccaag tggccaaagt cctcgccccc ttgccctacc tgacggtgga tcaagtcaga
     4321 gcgacggagc cgggcgaggg cggacgccca tgagtggcca cgtgcggttg cggaccacgg
     4381 cgatacgcat caccccgcgg gccggcgtca tcatcgcgat ggcggcgttc gtgggcgtgg
     4441 tggccttctt ctggccgttc gtggtcgccc ccgggaagtt cggctccagt tacgcgccgc
     4501 cgctcatctt cggtgtgctg ctcgtcctgg tcctgtgcgt ggtgatctcg gagatcgccg
     4561 agggcggcat caactccaag gcactcgcca tgctgggcgt actgtccgcc gtcaacgcgg
     4621 cgatccgccc gctgggggcg gggacggccg gcatcgagac ggtgttcttc atcctggtcc
     4681 tcgccggccg cgtctacggc cccggcttcg ggttcacgct cggctgtacg tcactgttcg
     4741 cctccgccct catcacgggc ggcgtgggcc cgtggatgcc gtaccagatg ttcggctgtg
     4801 ccttcgtggg gatgctggcg ggcttcctgc cgcgcgcctc cggacgtctg gagatcctgc
     4861 tgctggcggt gtacggctcg ctgtccggct atctcttcgg gttcctgctc aacctgtcgt
     4921 tctggccgtt ctcactcgac cccaacagtt ccatcgcgta cctgccgggg ctgcccttca
     4981 ccgagcagtg gcaccgctac ctcgccttcg acctggccac gtccctgggc tgggacacgg
     5041 gacgcgcggt caccaacttc gtgtgcgtcg tcctcgcggg ccctgccgtg ctcaccgtct
     5101 tccggcgcgc cgcccgcaaa gcgcgcttcc aggcgcccat caccttcgcg ccgcagcgcg
     5161 gcaccggcgc ggacacaccg tccgtcgagg cctagccgag aggccgcgcc gccccatgcc
     5221 ccgcacggcg cagggacgcc gtgcggtcct tcccgctcca gaaaggctcc accatgcgtc
     5281 agaccgtcct gcgccgaacc gtcctgtcca ccaccgccat aggtctcgcc ctgacggcga
     5341 ccccggcctt cgcctgcccc gcgccgaacc cgaacgctcc cgtcgtcgtg acggtcacgg
     5401 tcaagggacc gaacagcacg ctcttcaacg gcaaggtcag aaccaagggc cacgacgtga
     5461 ccaccacgac cggcggcgcc cacaagtgcg acggcaccaa cggcgccaag aaccccgccc
     5521 ccgtccccac tccgacagcc gccctcgacg acgccgccca ccagcgcggc ttcgcctggg
     5581 acggcgcctg gtacgcctcc ttcgacgact tctccgtcga cacgatcaag aacgtgagcg
     5641 gcggagcggc ggcctactgg aacatctcgg tgaacggcac ccccaccccg gtcggcggct
     5701 gccagttcgc cctcaaggcc ggcgacaagg tcgccttcac ctggaccagc ctctagcagg
     5761 ccccgttcgg cggggcgctt cccctccgac cgagccaccc tcgggcgcgg cccgcccccg
     5821 atcgcccgag acacaccaca cggtgctcgc gcgggagacg tccggtctcc cgcgcgaagc
     5881 ccggagacga cagcacgacc gacggaccga ggacgacccg catacccgca gactcccctg
     5941 cgaaagggac ggcagacgct ccgaggagtt cacatgtcct ggcaaccgca gtcaggtccg
     6001 cgccgccgaa cgggccgccg ggtgttcgcg tacccccggg gcagcccgtg tccccgtgtt
     6061 cctccgcccg tcgactcctc ccgcttcgca gatcgtggcg gcgcgtcgca gagctgccac
     6121 tcgggccatt tgccccatat tcctggttat gcattccact gcgcgcacgg ccgccaaccg
     6181 gtaccccgag cgggtcacct acgaacggga cgcggtctac gccatcctcg acgaggccct
     6241 cgccgtccat gtcggcttca acacggatct cggcccggtg gtcatcccca cccttcacat
     6301 gcgggtcgac gatcaactgc tcctgcacgg ctcggcgttc ggccgtttca tcaccaccgc
     6361 cgcatccggc gcgccgctgt gtgtgaccgc gaccctgatc gacggcgtga tcctcggccg
     6421 ggcctcctcc caccactcgg ccgcctaccg ctccgccatg gtcttcggca ccgccagccc
     6481 catcgaggac gagcgggaac gcgcggatgc cctcgcccag gtcgtcgaaa gcgtcatccc
     6541 cggacggctg tccggcccgc acgccgcacg ccgacccaac accgaggaag cccggtacac
     6601 cgcctgcctg accatgccca tcgaggagtt ctcgatgaag gtccgcgccg gtttcgcccg
     6661 cgacgagccc aaggacgacc atgtcgaatc ctgggcgggc tggattccgc tgaccaccac
     6721 cccgggtatc cccgttcccg acgagatcac cggcgaccgc ttccccgccc ccacctacga
     6781 cccttccgtc caccgtttcc gccaggactg accacgcccg cacggagccc cctggcgagc
     6841 gctcccgagg tacgcccggc cgaagcctgt ctccccctgc cgtccatcgc cgcaccggtc
     6901 gccacccaca ccccggcgct gcgcggcggg cggtacgtcg ccggctccgg tcaactgccc
     6961 acgtccgact gccagttggt cgacgccggc aggcggcggc gcacaaggcg caccggagca
     7021 ggccgcgcac gcctcctcca gatcccgctg gaccggcgcc tgagctgaag gcgtcggccc
     7081 ggccatcacg ccgagtccgt acccggggac ctgtccccgg tccccgcact gaacgaaggt
     7141 ccgacacccc atggtcccca cccttctggc caccgcggta gcggcgctgg tccgctcgct
     7201 cgcggccctg tggctccagc gatggaacat cggcgcaccg gcgttcatgg tgctggccgg
     7261 gttcctgctc gggctggaca ccggcgacac ggtcgagagc gccctcaaca cccatgtcgc
     7321 ccagcacgtc tgtgagatcg tgctcgcctt cctgctgttc atcgacgcca ccgagatccg
     7381 cggcggccgg ctctggggca cctcgccgcg gctggtcgcc cgcgtgctcc tcgtggccat
     7441 gccgctgagc ctgggcgcgg cgatgctgct gggcgcctgg ctgttcccgc acctgccctg
     7501 ggcggtgctg ctcatcatcg cgtgcgtcgt cgtgccgatc gacttcgccc ccgcggagca
     7561 cctcgtccgc gaccagcgcc tgtcggcgcg ggtgcgcagc gtcctgaaca tcgaaggcgg
     7621 ttacaacgac ggcatcatct ccccggtgtt cctgttcgcc ctgctcctgg caggcagcgc
     7681 ctccggcgtc agtacaccgg tggaagcgct cgccaccgcc ctcacccagg caggggtggc
     7741 catcgcggtg ggactggcgc tgggcgcggt gatggcctgg gccttggacc gggccggccg
     7801 ggccggctgg atgaccgatc agtcacggcg catcgcggtc gtgctcaccc ctgtggtgac
     7861 atactgcgcc gccgttcaac tgcgcggcaa cggcttcgtg gcgtccttcg tgtgcggtat
     7921 cgccttccgc tacctccacc gcgtcctgac cgcccgcgcg atccgcagca tcccccggct
     7981 gccacccgca cagccgcccg cgcgtgcgtc gacggtcctg acccacgact tcggcctgat
     8041 cgaggacgtc accgccctga tgaccctcac catgtggttc gtggtcggca tcgccaccgt
     8101 cgtcaccccg gacctcggcc tcagctggca ggccgctctc ttctgcctgg gcgcgctcac
     8161 gctcgtacgc gtccttccgg tcctgggctc gctgaccgcc tctcccctgc cgcgcgccga
     8221 ccgtgtgctg ctcagcctgc tcggaccgcg gggaacgacc tccatcgtct tcggcctcat
     8281 cgcctacaac cagctgccca ccggcccggg agccgacacc gtcctgctga ccacggtgct
     8341 ctgcgtcctg ggcagtgttc tgctccacgg catgggctcg gacaccgtca tccgccgcct
     8401 cgcaccgact ccccgctgac cgcgacagcc acggcactca cccttcgccc gatccgggcg
     8461 gttcacttcc ggtgggtggt ggcgagggct gcggtgagac tgccggcgag ggcggcttcg
     8521 tcgcgttccg cgctcgccca ggcgacatgc ccgtcggggc ggacgagaac ggcgcggacg
     8581 tcggtgaact cggccggcgg ctcgtgcggg gtggcggtgt ggacgtgcag ccctcggccc
     8641 gcgtatccag tgaggcggcc gctgccggtg aggtccagca ggaggtggcg atcgacgccc
     8701 agcagcgcga acaggccggt gtcgccgagg gccaggtcgg gggcgcgggt gccggtcagc
     8761 gggtggtcgc cgggcgtggc cggcgggtag gtgacggcga gggaactgac ctgcgcggcc
     8821 aggtggtcgt tgaggtcggg cagggtggtg atcagccggg cgagcaggcc gcgcaggtcg
     8881 agtccttcgg gggtgaaggc ggtcatcagg gcgacctggg cgcggctggc ggcggtgagg
     8941 tcggcgccga cggggtggcg ctcggcgtgg taggtgtcca acaggcctgt cggcgcccag
     9001 ccgttgaggg tggcggcgag tttccaggcg aggttggcgg cgtcctggat gccgacgttc
     9061 atgccgacgc caccggcggg gaagtgctgg tgggcggcgt ctccggcgag gaagacgcgg
     9121 cccttgcggt actggtcggc gaggcgggtg gcgttgccgt agcgggagag ccagaccggg
     9181 tcgcgcaggc cgaagtcggt gccggccatg gcggccacgt tcgcgcgcag ctcgtccagg
     9241 ccgaagtcgc cgggccaggt ggtggtgagg tcgcgggggg tgatgccgac caggcggtgg
     9301 acgccgccgg gcagggggac ggccatgagg gcgcccgcgg ggccgaagta gctgtagccg
     9361 gggacgggcg ggctgtccag gaccacgtcg ccgagccagc cgaacacggt ggcgggggtg
     9421 ccggggaagt cgatgccggc cgcggcgcgc acggtgctgc gggcgccgtc gcagccgacg
     9481 aggtaggccg cttggagagt ggagggcccg tgcggtccgg cggtgtgcac ggcgatgtgg
     9541 tcggggtgct cggtgaagcc ggtgacctcg cggccgcgca ggatgtgcgc gcccagggcg
     9601 agggcctgac cctccagcag tgcctcggtg cgctcctggg gaagggcgag ggtgtgcggg
     9661 aaggggctgg gcaggcggcg gaagtccagg cgggagtcga gggcaccgaa atggcctccg
     9721 ggcagcggta cgccctcgct cacgaaggga tggtgcgcac cgcgagaggc aaaggtctcg
     9781 atggtgcggg gatgcaccgt cagggcgcgg gagcgggagt cgcgttcgga gcggggctcg
     9841 atcacggcga cggtgatgcc cgcgcggcgc agttcgccgg cgagccacag gcccacgggt
     9901 ccggcacctg cgacgacgac ctggtgattc atggtccttc tccttctcgg tacaggctct
     9961 tggtcagtga ccaatgctcg atgcggagta aactaggtca gtgaccaaga agcaagccgg
    10021 agaagacacc gcaggccagc tcacccgcgc cgcagtcatc gacgcggccc tccaggtgct
    10081 gggagagcgc ggcctcgacg gcctctccac ccgggcggtc gcggaccgcc tcggggtgcg
    10141 gatgaacacc gtgctgtggc acgtgaagac caaggcccgg atgctggagc tgatggccga
    10201 cgccgtcctc gccggtatcc gctacgacga cctgcccgac gcccctctgg cacgcgcccg
    10261 cgagctggtc ggccgttacc gccacgcgct gctcgcccat cgcgacggcg ccgccctggt
    10321 caccggcacc tatccggccg aaccgaacac cctgcgcttc gccgaccgcc tcgtcgacgc
    10381 gttcctggaa gccggtaccg atgagcggca ggcggcgtgg acggcctgga cggtcaacta
    10441 cttcactctc ggcctgaccc aggaggagca ggccgagggc gaggaggacg atgcgaggct
    10501 cgcccaggcc gtcggcctcg gcacacaccc ggcgctgcag cgcgtcctgc cccatctccg
    10561 gcagaacttc gacgagcgct tcgccttcgg ccttgaggcg gtcctgtccc gcattcccga
    10621 gtgacagcac gggtgttgcg agctttacgg gcgtcccggc cgcggtgtct cggcgaccag
    10681 tacgcccttg agccgaattg accaggcacg gaactgttcc ggcgtgcgtc cgcgccggcc
    10741 gatgggccgt caggacggtg atccggtcac ggtgtcggga gggccggtgg accaactggc
    10801 gcggcgcgaa ctcggtccgg cgccactcgt tcgcgtgatg ttcgccgacc cggctgccgt
    10861 gaaccccgcc ttcaacaccc catgcctgaa gatcaaccag ttcggccgat gcacaagaca
    10921 tcgcacaaga aggcgggccc cctttcagat gacctcattc gcggcgcggg actgtacggt
    10981 gctggccggg cgagccggtg agcctcgcct gtcaccggca ctgctggaag acatgttccg
    11041 gctgcgctac gaggtctttc accgccggct gggctgggcc gtagacgtcg acaacggcct
    11101 cgaacgggac gagttcgacg acctcgatcc cgtctacgcc atcgcggtcc atcgccccag
    11161 caaggccgtt gtgggctgcg tacgcgtcct gccgaccacc ggcccgaaca tgctccgcga
    11221 cgtgacggcc ttccatgcgg ccctgcaagg ccggcccgcg ccctgctcgc cgcacatctg
    11281 ggaagccagc aggttcgcca tcgatccccg ggtccgcccg gcgccccgcc tcgacccccg
    11341 ggggttccag gccgtgcccc gggcgctgct ggccgccatc ggcacctacg cggccgagca
    11401 cggagtcgac caggtcgtgg gactttccgg agtcaccatc gaagccaagt tccacgccag
    11461 cggcgtaccg accacccgca tcggcgacgc gccttgccac atcggctccg tactgtgcac
    11521 ggcctacagc ttcgccgtcg ccgacctggt cgcactcggg gaaccggctt cgccgcaggg
    11581 cacctccggc cagctcatcc actgaaaccg ccgaccaagc acgactgccg caagtcgagc
    11641 tccacgtaat gtatttgacg catcgtcaag tctcatcgcg ccttgaccgt catgcgacat
    11701 gtgcccctgc ggcgagagtg aacgtagtct cggcgacatg gatgatgtcc tgcctctgtt
    11761 cgcgatcttc ggcggtctgg ccgcggtcct tgccgcactg gtgtggctgg cacgccacgt
    11821 acgccgccgg ggcatagccg gtgcaggcgt cgcggcggcg ctggcctcgt gggaagaggc
    11881 gtatcgcgtg accgctcacg agtcccactg ggaaatcaag gcgcaggcgg agcggcagtt
    11941 ctccgtgctg tcccctgacg gccactggcc gcgtgccggc gagggcaatc cccggccgac
    12001 tgcatcacgg cgccgtcgag acggcaagcg tctccgccgc ctggtacgcc gacggcgacc
    12061 gcggggctag cggtacgcca atcgcccggc cgacatcgcc ttacctgagc cgctcggcgc
    12121 caagcacgag agcaggacct ttccttctcc tcgtccgctg cccccgcagc gtcgaccggg
    12181 gtgccgtcgt gcctggcgtt ccacacccga agcgctgtcg cggcgaaagg aatcccagcc
    12241 gccgcgggat cagcgcagcg aggagccgtc ctgcttcagc tgcatctgcg ggcgccctgt
    12301 caccaggagc caggccggca gcgacgcgat gcacatgagg gccaggattg cgggtgatgc
    12361 cacgagtacg gcggccgtga acaggctgat ccagccctgc cgggtgatgg cgaggagcat
    12421 gccgagtacg ccggccgaga cactgacgga ggggttcacc gccggcacga gcgcatgcgc
    12481 gcacagaccg aaggcggctc cgatgaacac ggccgggaag atccgccctc ctcggaatcc
    12541 gcaggacgcc gcgatcacga gtgccgccag cttcacgacg gccatgacgg cgaaccgacc
    12601 ggccgaccac ccgtccgggt cggcggccag ctcgcccacc tcgtgcaggc ccttgaacag
    12661 ggtcaagtgc ccgcccaggg cgccgagcag accgagtacg agcccgccta gcggcagcat
    12721 cagcatcggg tgccgcagtt ggccgaaggc gcggtgcacg tacgggaaga ggcagacggc
    12781 cagcatgccc agcgccgcgg ccaggcaggc gagcacgacc gcggcgagca ggtcgtccca
    12841 cccgggcttc ccgaagggcg gcaggccgag gtcgaaggag ggcgaggcga gaagcgtcgt
    12901 cgtcaacgcg cccgccgcgg cggcgagcag cggaccgaag aggttgtccc acagtgaccc
    12961 cttcaccggc aggggcttgc ccgccagcgc ttcggagacc acgagggcgg cggcgacggg
    13021 cgtgccgaag agtgcgccga gcgtcgcagc ggtggccagc ggcacccaca tccgtcccgg
    13081 ggccttcggc accgccctgg tcccgagcca gaacgcgagc gcggcgttgg cggcgatgat
    13141 cggattctcc gggcccaggc tgggaccacc ggcgagcatc aagacgttgg cgacgagcag
    13201 tcccggcacc acatgcgccc gtagcggctc cgactcgccg aggccgagcg tggcggggtc
    13261 ggggcccgcg tgtccgggcg ccttccacac cacgagcccg accagaacgc ccgtcagggt
    13321 gaggacggcg atcatccaca gcgacgagta gccgccgatg ccgagcgcac cgggcaggtc
    13381 cttccaccac acgtcttcga gcctctcggc caccgcactg atcgcgagga acagcaggct
    13441 gcatcccacc cccaccgcaa gagcgggcac gacgacaggc agcagggtgc gggccgagac
    13501 ggaagggagg gccgcggggg ccgccgacgc gccatcgcct ggagtagtca cagcctcacc
    13561 ctaggtgatg ggtccggttc gctcgtgctc cacctgcacc atcccgtacg cggcgggagt
    13621 ggcccggccc ggcggaaccc tttccaccgc ccccggcggt gggggatgat ccgcgcatga
    13681 ctgggcagcg aaccgacgga gcgtcatcgg ccgatccggc caacacctac ctccagtcgc
    13741 tcggcgagcg gctgacggcg gacaagtgcc gtatgacagc gtcgaattgg ggcgagcacc
    13801 cggtcgtgat cggcagccgg tcggaccgca aggcgcggtg gttcggcacc aaggtggagc
    13861 tgttcgtctt cgccgccgtc gtgcccggcg tcgacgacgc ccacttggcc gagttcacca
    13921 agtgggcgat gtcctatgcg cagagctgcc gcagcgggtt gcccggtgcc cgcaacgcca
    13981 tgatggtcct gcccgctctg atcagcgggg gcgttcacac gtccgccagg gagtgggcct
    14041 cccgggacgc ccgggtcctc ggcacgaccg tgatcggccg tccgctcacc gtggaagcgg
    14101 cccagggggt cagccgggtc accatgtacc ggggcggaac ggtgtggggc ggaatgttca
    14161 cgcgccatgt gctggagaag gcgtccctct acttcccctg acttctgact ttctgcgtcc
    14221 cccgaccatc cactcccccc tcgacatcgc cgacggtcag cgcacggcgg cgaccccgcc
    14281 gatccctgtc gccggaaggc ggtccgggtg aacacggctc tctccacgcg ctgttcacga
    14341 cgcgcacggg atgtgtctca gaacaccgtc cggaatccgg acggcctggc acccccctcc
    14401 tccggcccgt aggctgacct cagcagctgg ttcactccgt ccgccaggcg gggtgtcgca
    14461 agagggaacc cggtgggaat ccgggactgc cccgcagcgg tgagtgggaa cgaccgccgt
    14521 catacgcact gggtccgaga taccgggcct gggaagcgac ggccagtagg tgtcctccga
    14581 cgaggagggt gtgcccgcga gtccgaagac ctgccaactg cccgtgcacg gaccattccg
    14641 tgcgcggata tttccggtga cctcgagggc gggtcggcgt acacaccaga cggaacgacc
    14701 gtgcctgtgc ggcgcggggt cgttgccgtc cggttcgtcg tttccttcgc gctctcgtcc
    14761 catccccggg gatgttcagg agtcatctcg cgaaggagat ttccgtgaca gcgcagtccg
    14821 cagccgcggc agcacaggcc accgtttacg gctacccccg tcagggccgg aaccgtgagc
    14881 tgaagaaggc catcgagggc tactggaagg gccgcgtcac cgccgacgcc cttcggaaca
    14941 ccgccgccga gctccggcag ggcaactggc ggcagctcgc cgacgccggc atccacgaag
    15001 taccgaccgg tgacttctcg ttctacgacc acgtcctcga caccactgtc atggtggggg
    15061 ccatccccac gaggcaccgt agcgccgtcg acgccgacgc gctggacggc tacttcgcca
    15121 tggcccgcgg cacccaggag gtcgcgccgc tcgaaatgac caagtggttt gattcgaact
    15181 accactatct cgtaccggag ttgggccccg acaccgtatt cgccggggac tcctcccacc
    15241 aggtcgggca gctgaaggag gccctcgcgc tcggcctgtc cgcgcggccc gtgctcgtgg
    15301 gaccggtgac gtacctgctg ctcgccaagc ccgccccggg cgtcgccgcc gacttcgaac
    15361 cgctcaccct cctggaccgg ctgctgcccg tgtacgccga ggtcctggcc gatctgcgtg
    15421 cggccggagc cgagtgggtg cagctggacg agcctgccct ggtccaggac cgcacccctg
    15481 ccgaactgaa cgccgccgag cgggcctacc gcgacctggg cgccctcacc gaccggccca
    15541 agctgctcgt ggcctcctac ttcgcccggc tcggcgacgc cctgccggtc ctggccaagg
    15601 ccccggtcga gggcctcgcc ctggacttca cggagtcggc cgcggccaac ctggacgccc
    15661 tggccgccgt cggcgggctg ccgggcaagc gactcgtcgc cggcgtggtc aacgggcgca
    15721 acatctggat caacgacctg cagaagtcgc tgtccaccct cggcacgctc ctcggactcg
    15781 ccgaccgggt cgacgtcgcc gcatcgtcct ccctgctgca cgtcccgctg gacgcaacca
    15841 tcgagcggga catcgagccg cagatcctgc gctggctcgc cttcgcgcag cagaagactg
    15901 ccgagatcgt cacgctcacc aagggaatct cccagggcgt cgacagcatc aaggccgaac
    15961 tcgccgcgaa ccgggccgac ttggcgtccc gagcggcctc gcccatcacg cgtgacccgg
    16021 cggtgcgcgc ccgcgccgca gccgtcaccg acgccgacgc gcgccgctcg cagccgtacg
    16081 ccgagcgggc cgccgcccag cgcgcccacc tgggcctgcc gctgctgccg accaccacca
    16141 tcggctcgtt cccgcagacc gccgaactgc gcacggcccg ggccgacttg agggcgggac
    16201 ggatcgacac ccagggctac gaggcgcgca tcaagaatga gatccgcgat gtcatctcct
    16261 tccaggagga gaccggcatc gacgtcctgg tgcacggtga gcccgaacgc aacgacatgg
    16321 tgcagtactt cgccgagcag ctcaccgggt acctcgccac ccagcacggc tgggtccagt
    16381 cctacggcac ccggtacgtc cggcccccgg tcctcgccgg tgacatcgcg cgccccgagc
    16441 cgatgacggt ccgctggacg gcgtacgccc agtcgctcac cgaccgtccg gtgaagggca
    16501 tgctcaccgg gcccgtcacc atgctcgcct ggtccttcgt ccgcgacgac cagccgctcg
    16561 gggacaccgc ccgacaggtc gccctcgctc ttcgcgacga ggtcaacgac cttgaagcga
    16621 acggtacttc ggtcatccag gtcgacgaac cggccctgcg tgagaccctt ccgctgcgcg
    16681 cggccgaccg acccgggtac ctgacctggg ccaccgaggc gttccgtctc accaccagcg
    16741 gggtgcgacc ggacacgcag atccacacgc acatgtgcta cgccgagttc ggcgacatcg
    16801 tccaggccat cgacgacctc gacgccgacg tcatcagcct cgaagcggcc cgctcgcaca
    16861 tgcaggtcgc ccacgaactc gccgcccacg gctacccgcg cgaggccggc cccggcgtgt
    16921 acgacatcca ctccccccgg gtgccgagca ccgacgaagc cgccgatctc ctgcgcaccg
    16981 gcctcaaggc catccccgcc gagcgcctgt gggtcaaccc ggactgcggc ctgaagaccc
    17041 gcggttggcc cgagacccgg gcctccctgg agaacctggt cgccgccgcc cgcacggtcc
    17101 ggggcgagct gcccgcctcc tgatcgagaa agccggtggg ccgggacgct ccgagcgtcc
    17161 cggcccaccg cgtggcgccg ccgtcctggg gtctgtcggg cacgccttct cagctctgaa
    17221 cgcgttggtc gtaggcggtt tggtgcgccc ggatctcgtc cgtgttgtcg accgtccagg
    17281 cgtacagccg cccgaacggc tcccggaggg attcaccgag cggagtgagg gagtactcga
    17341 ccccgaccgg cgaggtgggc agcacgcggc gcgtgatcat cccgttgcgc tccaggcggc
    17401 gcagcgtctg ggtcaggacc cgctgggtca cgccttcgag gcggcgcttg atctcgttga
    17461 accgagtggg cttgtcgagg actgccatca ccatcatcga ccacttgtcg gcgatctggt
    17521 cgaggatcgg gcggctgggg cagtcggccc ggtagacgac tccgccgtcg gcgccggttg
    17581 gagaagtggc catgtcggta tccttcgcga tccttgcgat gccgaaagtg cgttattgac
    17641 gccggtcact cgccatcgga ccgtaagtat gcatcaggaa ccaggtgcgt atcaggtacc
    17701 gatcggagtt ctccatgacc cacgacatct acccgaccct gcgggtgagt cgcgaggacg
    17761 gcatcgcacg cgtcaccctc gacaacccgc ccgtcaacgt cctggacgtt gccctgatgg
    17821 ccgacctccg gcacctgctg accgcgctga gcagcgacgg ctctctccgg gtgatcgtgt
    17881 tcgaaagcgc caatccggag ttcttcatag cccacgtcga catgtccctc atcgacactc
    17941 cggacgcctt cgaccagttc gcgcccgacc ttccggacgg cgtcaacgtc ttccaggctc
    18001 tgggggaact gctccggcac cagccccagg tgaccatagt caagcttgcc gggatggcgc
    18061 gcggcggagg ggcggagttc gtcacagccg cggacatgac gttcgccgcg atcggccgcg
    18121 ccgggatcgg ccagatcgag gctctcatgg gcatcgtccc cggcggcggg ggcacgcagt
    18181 atctcgccgg ccgggtcggc cgcaatcgcg ctctggaggc ggtgctgggt gcggatctgt
    18241 tcgacgccga aaccgcagag cgctacggct gggtcaaccg ggcggtcccc gccgacgagc
    18301 tcgacgatgt cgtcgaccgc ctcgcccgca acatcgccgc cttgcccgag ggcgtgatcg
    18361 cagcggccaa gcgcgcgatc gtccccgagg acctggccga gggtctcctg cgggagcacg
    18421 acgcgtgggc ggcccagttc gcgcgccccg acgccgagcg tctcatccgc ggcggactgg
    18481 cccacggcgc ccagacccgc gacggcgagc gcgatctgga gggcctgctc cggggcctgc
    18541 ccggatagcc cacatccgta cccggcccga actgcaccag tagcaagcct ccttgggcgc
    18601 agtggtgcag cccccgctcg gtcttcgcgc acaccgcatg cgtgtgggcg ccgcgagacc
    18661 ctactcgtca cttgtcccgg cggcggaggc gcacggctgc cattcctgag cccacggcga
    18721 gaagaacagg cagggaggcc acccacgcct cggtggcaga cgcgccggtc aacgtcatga
    18781 tgaccccgcc caacacatag atggccagga aggcgcccac cagcggtgtg atcccactct
    18841 ttggcggatt ggtccttctt gctctcatcg cgggaatcgc cttctcgttc ctgaagaggg
    18901 aggatggcag tcacggctgc gtgctcggcg tacttgtcgc cggcacagtt ccgctcgttc
    18961 cctttctcct catcggaatt cccctgttgt tcaagatgtt ctcgggatga agcgggtagc
    19021 caggtacgcc aactccccct gcgttgcgcg gccttgacgc tggcgggcag atccgaaatc
    19081 tgcaaggcag accggcgggc cgtccggcgc cgttgttcgg cttcgcaccg cgggttgcgg
    19141 tgtcacgggg cggcagggtc gaggtcgctc acgtcgtcca aaccggcctt gcggttgagg
    19201 tggccggtga cgcgggcgac cgtggtccgg ggaaacaggc gcgacgccca gactccggcg
    19261 cggttcgagg cgcgtccggg gaaggagatg gaccggccgc gtgcgaagtc gtcgagtgtt
    19321 ctggcggcga cgtcgacggg ggtgtccgtg accttcggat ccatggacgc ggtcgtacgg
    19381 tcgaagaatc cggtggcggt ggctcctggg tgggccgcca tcacgcgtac gccggtgttg
    19441 cggacctcct cggcgagtgc ctcggtgaac gagagcacga acgccttggt ggcggcgtaa
    19501 ctggcctggt agggcatggg ctggaaggcg gcggtcgagg cgacgttgat gatgccgccg
    19561 cggccgcgtt cgaccatgcc ggtgcccaga aggtggacca ggccgatcag cgcggtgacg
    19621 ttgacgtcga cggactggaa gttgggttcg aggggccggc cgagaaaggg ccccaccgat
    19681 cccatcccgg cgttgttgac caagaggtcg acgttcaggc cgagttcctc gatggtgttc
    19741 accaccgcct gcggggagcg ccggtccgag aggtctgcgg cgatcacgtc gactcggacg
    19801 gaatgggtct tccggatctg cccggcaagg gtgtggagtg cgtcggccga gcgggcgacg
    19861 aggatgaggt gtgcgccacg ggaggcgagg tcccgtgcgt aagcctcgcc cagccccttc
    19921 gaagcgcccg tgaccacggc ggtgctgttc gtgtagtcgt gcatgagtga gtgcttcctg
    19981 ttcggctggg cgccgggccg cgtcggagtg gacgggcctc gggaaggacg gaacgcgcgg
    20041 agtgtcccac tatggggacc cctggggacg gcccccgcat ccacagcggg aacaagggcc
    20101 aattacttcg agtctcgaag gaacgtaaca cttcgagact cgaagtaaca aggactaggg
    20161 tgaggccatg acgcgagaca cccttgtggc ggcggtggtg gcgaaccacg agatcttcat
    20221 gcggaccagc gaccggatcg ggaccgtcct ggccgaacac ggtctgacgc cggcgaccgc
    20281 tcaggcgctc tggtcgatcg acccggccga ggcgccgccc tcgatgaagg aactggccgg
    20341 caggctgtac tgcaacgcgc ccaacctcag cttcgtcatg aatcagctca ccggtcgggg
    20401 actcgtcgaa cgttccgccg accccgccga ccgccgttca cgcgtcgcag cactgacgga
    20461 agaaggccga cgcgtgcggt cggcgctgat cgaggcaaca ctggccctga gcccgcttgc
    20521 ccgactggac gccgacgacc tgcacaagct ggtgagcctc ctggggaagg cgctcgaacc
    20581 gacgtcaggt ccccggcgct gaccaggtcg cggaagcgaa ggtattggcc gaccggggtg
    20641 cgtctgcgga aacgccgcga tgccggcgca ggagttcccc atcttcggcg tgcgtacggt
    20701 gcgcgtggcg caggccgcct tgggcggtcg gggcgtgggg aactaacgcg gcgcggagac
    20761 gtgtcggcga cccatcgggg cggaggcgcc ccggcttcat ttcatgacga cgaactttgc
    20821 gaccgtgacg acggagatcc gtcacaacct cgcgatcggc ccccggcgga acatcgggat
    20881 cggccccccg catgaggcac gtcccgcgca tccggcgcga gctggggcac cccgttcggc
    20941 gggtgccggt ggcccgcgtc gtcacggcgg cccgcggccc ggtcaggcgc gccactcccg
    21001 gaaggagtcc cgtttcccct cccctgggca accaacgccc gcgcggcaaa gagaacaagg
    21061 tcacaccccg tcatctcctg ctcatctgtc gatctgacct agcatccggg catgacggtc
    21121 ctgcccgacg acgggttctc cttggcggcc gagtttcctc acgcgacgca tgagcagtgg
    21181 cagcacctgg tagcgggtgt tctgcgcaag tcgggaaggg aagtctcggc cgagacggcg
    21241 gaagacgccc tgtccaccgc gctcgaagac gggctgcgcg cccgcccgct gtacacggct
    21301 cgcgatgccg cgccaccgac cgggctgccc gggttcgcgc ccttcgtgcg cggcggccgc
    21361 gccgaggggc agacggccgg cggctgggac gtgcgtcagc cgcacagcgt cccggactcc
    21421 gccgcggtgc tctccgacct ggagaacggc gtcacctccc tgtggctctc cgtcggcgag
    21481 cacacgggct ttcccgtgtc cgcgctgccc gccgccctcg acggcgtcta tctggatctc
    21541 gccccgatcg tgctccaggc cggcgcggag agcgccgcgg ccgcggcaca actgctgcgc
    21601 ctgca
//
