LOCUS       NZ_BMUU01000001        22673 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Streptomyces xanthochromogenes strain JCM 4594 sequence01, whole
            genome shotgun sequence.
ACCESSION   NZ_BMUU01000001
VERSION     NZ_BMUU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xanthochromogenes
  ORGANISM  Streptomyces xanthochromogenes
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1270804)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650355.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:28:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,827
            CDSs (total)                      :: 7,752
            Genes (coding)                    :: 7,642
            CDSs (with protein)               :: 7,642
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 110
            CDSs (without protein)            :: 110
            Pseudo Genes (ambiguous residues) :: 0 of 110
            Pseudo Genes (frameshifted)       :: 24 of 110
            Pseudo Genes (incomplete)         :: 94 of 110
            Pseudo Genes (internal stop)      :: 7 of 110
            Pseudo Genes (multiple problems)  :: 12 of 110
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:05:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 502607
            Orig. end                         :: 525280
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22673
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="4"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22673
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22673
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12673](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12673)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            920..1912
                     /db_xref="GeneID:96288478"
                     /locus_tag="IE233_RS02125"
                     /old_locus_tag="GCM10010326_04510"
     CDS             920..1912
                     /EC_number="2.1.1.45"
                     /GO_function="GO:0004799 - thymidylate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006231 - dTMP biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288478"
                     /inference="COORDINATES: protein motif:HMM:NF012524.5"
                     /locus_tag="IE233_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04510"
                     /product="thymidylate synthase"
                     /protein_id="WP_229892064.1"
                     /transl_table=11
                     /translation="MDFETFHDAYPRMLRWLIEEPAYRNAPRGYASREQLGVSFRIARA
                     DQRVPFVPARRLNIVFNFAEALWYLAGRDDLDFIAYYAPSISKYSADGHRLTGTAYGRA
                     LFGAAEGRPDQWPAVVETLREDPDSKRAVIQIFRGEELQVSGNPDVSCTLGLQFLLREG
                     ALHAVGFMRANDVYRGMSSDVFSFTFLQEVLARELGVPVGSYVHQVGSLHLYDPDHSRA
                     LEVLADPAADEPSAWSFPLMPEGDNWPYVREVLAVEEQLRLGRHTLGATPASYGLPDYW
                     TQVLVLFEVHRRIRGKEPVGEAQLSLLSPLYRHLVEERWPAIAPAPVAG"
     gene            1927..2670
                     /db_xref="GeneID:96288479"
                     /locus_tag="IE233_RS02130"
                     /old_locus_tag="GCM10010326_04520"
     CDS             1927..2670
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288479"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.5"
                     /locus_tag="IE233_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04520"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_190025986.1"
                     /transl_table=11
                     /translation="MTTSTHWHSTASIADGFDAYDDLPERLIGYPTVFAALGIGSPDVR
                     TVLDYGCGPGKVATRVTEICEADVVAADVSPRMLEIARTCRPHPRIDYRRIDSGKLTFL
                     ADGSIDAAMSCYVFINVGELPLLHEIAAEIHRVLRPGARYAVLDTNPDTTGVRFSTFRN
                     GEPGRTYACGERRQVLLDQPGGGEPLELVDHHWPRQTYLDVLGEAGFTDLTVEEPLLTD
                     PSALPGAAPAETIHPPFLIVTGVKQ"
     gene            2667..3164
                     /db_xref="GeneID:96295850"
                     /locus_tag="IE233_RS39710"
                     /old_locus_tag="GCM10010326_04530"
     CDS             2667..3164
                     /codon_start=1
                     /db_xref="GeneID:96295850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556032.1"
                     /locus_tag="IE233_RS39710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04530"
                     /product="nucleoside 2-deoxyribosyltransferase"
                     /protein_id="WP_202520077.1"
                     /transl_table=11
                     /translation="MTTTTATESVQQTHSVFLGGPFKALVDSDGAMNAAARTRFEVLIE
                     RLEAEGYHVYNAHRRESWGAKFLTPDECTRLDYDEISASSVFVAIPGHPASPGTHIEIG
                     WASALGKPIVLLLEEGVDYAFLVRGLHTVADVTCLTIGDTDRLATEVVDAVNRLARAGA
                     NG"
     gene            complement(3300..3884)
                     /db_xref="GeneID:96288480"
                     /locus_tag="IE233_RS02140"
                     /old_locus_tag="GCM10010326_04540"
     CDS             complement(3300..3884)
                     /codon_start=1
                     /db_xref="GeneID:96288480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087525.1"
                     /locus_tag="IE233_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04540"
                     /product="hypothetical protein"
                     /protein_id="WP_190025987.1"
                     /transl_table=11
                     /translation="MTAPLPLLFLDVDGPLNPYAAKPHRRPVGYRTHRLRPEGWIAQHP
                     TSLRAYVKPLRVWLNPAHGPALLALADRFELVWATTWEADANEWIGPLLGLPQLPVVTW
                     PTLRETSPDGTFWKTPCLVKYAAGRPFAWVDDDIGPADHRFVAAHHSATALLRRTDPRL
                     GLLETDFTALAAFAQNPGAIQGAGLPATPRG"
     gene            4109..4324
                     /db_xref="GeneID:96288481"
                     /locus_tag="IE233_RS02145"
                     /old_locus_tag="GCM10010326_04550"
     CDS             4109..4324
                     /codon_start=1
                     /db_xref="GeneID:96288481"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE233_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010326_04550"
                     /product="hypothetical protein"
                     /protein_id="WP_167160961.1"
                     /transl_table=11
                     /translation="MTSDELHTRITQLEAQLARPTPPPIGGQVSIPLEPIRHHAYTGDG
                     GPCTTSLFGERCAEPVDHHEIHDQHP"
     gene            complement(4407..5429)
                     /db_xref="GeneID:96288482"
                     /locus_tag="IE233_RS02150"
                     /old_locus_tag="GCM10010326_04560"
     CDS             complement(4407..5429)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016628 - oxidoreductase activity, acting
                     on the CH-CH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (86-330). E-value: 1.5e-22.
                     Score: 72.1. Matches aSDomain:
                     nrpspksdomains_IE233_RS02150_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GeneID:96288482"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177257.1"
                     /locus_tag="IE233_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04560"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_190025988.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-18, bitscore:
                     62.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNETALTVHQTARPHGFPTADHFSFAESTIPDPAPGSALVENLYW
                     SVDPYHRELMDDAPGGFALHAPLEGRSIGRVIASRTPRLAEGEIVFHRHGWRTHAVITP
                     DETRRLPRFDGVPLTAYLSTLGGTGLTAYVGLTRIARLQEGEDLFVSAAAGGVGTATGR
                     FARLLHAGRLVGSAGSAAKAVHLVREVGYDAVFDYHDGPVHDLLGRVAPAGVDVFVDNV
                     GGEQLAAAVGALREFGRIVRIGTISQYNTPGAPAPRFNYADIVEKSIRMEGFLVSNYRD
                     VQEELYAFAVPHLQSGRLALDETVIDGFEHIVDAFLGMLRGENTGKIIVRDRTQVPSAH
                     "
     aSDomain        complement(4440..5171)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE233_RS02150_PKS_ER.1"
                     /evalue="1.50E-22"
                     /label="IE233_RS02150_PKS_ER.1"
                     /locus_tag="IE233_RS02150"
                     /protein_end="330"
                     /protein_start="86"
                     /score="72.1"
                     /tool="antismash"
                     /translation="GEIVFHRHGWRTHAVITPDETRRLPRFDGVPLTAYLSTLGGTGLT
                     AYVGLTRIARLQEGEDLFVSAAAGGVGTATGRFARLLHAGRLVGSAGSAAKAVHLVREV
                     GYDAVFDYHDGPVHDLLGRVAPAGVDVFVDNVGGEQLAAAVGALREFGRIVRIGTISQY
                     NTPGAPAPRFNYADIVEKSIRMEGFLVSNYRDVQEELYAFAVPHLQSGRLALDETVIDG
                     FEHIVDAFLGMLRGENTGKIIV"
     gene            5539..6459
                     /db_xref="GeneID:96288483"
                     /locus_tag="IE233_RS02155"
                     /old_locus_tag="GCM10010326_04570"
     CDS             5539..6459
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288483"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177258.1"
                     /locus_tag="IE233_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04570"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_190026386.1"
                     /transl_table=11
                     /translation="MTGSDLVQQELRALVAVADTGGFSAAAEALGLTQSAVSHSVRGSE
                     RKIGAVLFERGRAGARPTPAGEAAVAYARRVLRLLDVLTAEARGAARPDAAEGPLRIAA
                     FRSAALHLLPPALQRLRARHPGIEPRVRIVRELGRGTAGEVADGRADLAIATLGGSAPL
                     PSGLVAGELLTEPYALVHAKGQGTPRSLPLVDWAENCGSYTRRWWAAQDWIPKATIEAE
                     DDGAVLSLVSGGHGMAIMPALSLAGAPDSVGITDLGPGRPTRRVGFVTTSELARSAVVR
                     SLVRELRATAPEAVPHLNNLALQGR"
     gene            complement(6490..7146)
                     /db_xref="GeneID:96288484"
                     /locus_tag="IE233_RS02160"
                     /old_locus_tag="GCM10010326_04580"
     CDS             complement(6490..7146)
                     /codon_start=1
                     /db_xref="GeneID:96288484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113584.1"
                     /locus_tag="IE233_RS02160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04580"
                     /product="FMN-dependent NADH-azoreductase"
                     /protein_id="WP_189762777.1"
                     /transl_table=11
                     /translation="MATLLHLDSSLFPAGASASRAVTDAFRKAWEAQHPQGTVVYRDLS
                     VDPVPHLDGLAASAAFVDPAAHTPEQAAAFAERMKLVTELEQADAVLIGAPMYNFTIPS
                     TLKAWLDQVVLMGRTAGPESTVKGLPITVVASRGGSYAPGTPREPFEYVQNYLGALLSE
                     MLGAEVDFIVPELTLAASNPAMSELIPLAEASREKALADAAEKAKSLAARVGSAA"
     gene            7246..7620
                     /db_xref="GeneID:96288485"
                     /locus_tag="IE233_RS02165"
                     /old_locus_tag="GCM10010326_04590"
     CDS             7246..7620
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288485"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529440.1"
                     /locus_tag="IE233_RS02165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04590"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_161244319.1"
                     /transl_table=11
                     /translation="MADQEERDSGQRHEPEACGRVGDGITQVFGLLGKRWTGLIVSALT
                     QGLDRFTDLRQAVPGISERMLADRLMELVAAGLVLREVDEGPPVRVSYRLTESGAALEP
                     ALTELAQWAEKYLLNGKGSC"
     gene            complement(7672..8562)
                     /db_xref="GeneID:96288486"
                     /locus_tag="IE233_RS02170"
                     /old_locus_tag="GCM10010326_04600"
     CDS             complement(7672..8562)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288486"
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955215.1"
                     /locus_tag="IE233_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04600"
                     /product="ABC transporter permease"
                     /protein_id="WP_190025989.1"
                     /transl_table=11
                     /translation="MTAPALPASDASSPPDRPAVRDGSGPDRVPRLWHELRAVHALVHR
                     DLLRLAAQPVHTGLMLVQPMLYLFILGGGLAALIPNSSLGGGYQTYLFPGVLMMTVQTP
                     AIMVGIRLITDRQSGYVRELLMAPVRRPTLLLGTCAGGTLVATVQGAVLLTLVGAIGLP
                     YDPLLLLTLLVGMMLTSFTLTALALTLAVTLDRPEVFNMLLGLVMMPLLLLSGGFFPVG
                     NLPGWAQALAAANPLAYGVDVLRRCIAARVPDRAAPTTVEWSGWQPPVLLEGTLLLTVG
                     ILALLWAAHRFGRPE"
     gene            complement(8559..9671)
                     /db_xref="GeneID:96288487"
                     /locus_tag="IE233_RS02175"
                     /old_locus_tag="GCM10010326_04610"
     CDS             complement(8559..9671)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288487"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031828.1"
                     /locus_tag="IE233_RS02175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04610"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_190025990.1"
                     /transl_table=11
                     /translation="MQPDAADEARTRATLPPTTAASPDLEPSAVQSAYAISTRGLVKSY
                     PGPDGATTHAVHGLDLDVHRGETFAFLGPNGAGKSTTISLLCALARPTAGQATVAGVDV
                     IRQPDEVRRRVGMLFQQSALDSDLTAEQNLHIHARLYGLSRRHARLRATETLEKVGLAD
                     RRRSRVRTLSGGMRRRLELARGLLHAPQVLFLDEPTTGLDPHARAQIWEYLRALRDQHG
                     NTLFVTTHYLEEAENCDRLGIIDHGRLVAEGTPLALKAAIGDDRVALRTGDDAAARHVV
                     AGLAPEGRAITLDADGVSLRIPDGSTWIPRLCAALAAQGIAVHAASATPPTLDDVFFHH
                     TGRSINAPPSHGTPTAMVPAATPAAIEEAP"
     gene            complement(9777..9932)
                     /db_xref="GeneID:96288488"
                     /locus_tag="IE233_RS02180"
                     /old_locus_tag="GCM10010326_04630"
     CDS             complement(9777..9932)
                     /codon_start=1
                     /db_xref="GeneID:96288488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104907.1"
                     /locus_tag="IE233_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04630"
                     /product="VenA family class IV lanthipeptide"
                     /protein_id="WP_167160951.1"
                     /transl_table=11
                     /translation="MENQDLEVLAHLHALPETDPIGVDEAQFGGTCACTGLLTLLNTVC
                     VGVSCA"
     gene            complement(10001..12673)
                     /db_xref="GeneID:96288489"
                     /gene="lanL"
                     /locus_tag="IE233_RS02185"
                     /old_locus_tag="GCM10010326_04640"
     CDS             complement(10001..12673)
                     /codon_start=1
                     /db_xref="GeneID:96288489"
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523352.1"
                     /locus_tag="IE233_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04640"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_190025991.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-17, bitscore: 60.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8e-47, bitscore:
                     155.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHATEVDLEVLLRRTLQATGMSERWTADVDEMWCRLVRPSGIR
                     RQQGWKLHVSATAASAPEVLVRALGVLLREESIFKFARSLEQVGALNSRATPRGSSGKF
                     ITVYPPSDEDAARLALELHKATAGLAGPRILSDQPYAPNSLVHYRYGAFVGRRRLSEHG
                     LLVWFMEDPDGNPVEDKRTGQYAPPSWAVSPFPASVPLPPQQDTAASSPVLLGGRFSVR
                     EAIRHTNKGGVYRGTDVTTGRAVVIKEARPHVEADASGGDVRDWLRAEATTLEKLKGTG
                     LAPEPVAMFETGGHLFLAQEEVPGVPLHTWVAERYRDVGSERYRADALAQVDRLVDLVD
                     AAHAQGWILRDFTPGNVMVRPDGELRLIDLELAVLEGDSMLPTTVGTPCFSAPERLVGA
                     PVSRTADYYSLGATVCFVLAGKVANLLTEEPATRPAQERFAEWLAACADVLSLPDVLTE
                     VILGLTRDEPGERWTPAAAREALRRANPARPERPAVATGRTEGPDGVTEIVITGMVNHL
                     VDSMNPADDRRLWPVSTQAGETGPCTVQQGAAGVLTALTRYFEATGDPRLPDLLATAGH
                     WMAARTDTASIRPGLHFGGRGTAWALYDAGRAIGDRELMDHAVALALAPLEPTPSYDIT
                     HGSAGSGLAAAHLWHRTGDPRLAERVVADADRLAAAARVEPPGVSWPVPAEAVSQEAGK
                     RYLGFAHGTAGIGCFLLTAAAISNRPEHMQLAVAAGESLVTHAVMVGEAAQWPAQATDV
                     PTAPYWCHGSAGIGTFLIRLWQATGDKRFADLARQAARAVVERASRAALTQCHGLAGNG
                     DFLLDMADATGDPAYRAMAQDLARLIASERAHRNSHVVFPNEYGNVSTSWSDGSAGILA
                     FLLRTRHTGPRHWMVQQPG"
     misc_feature    complement(11873..11875)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(13208..13228)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.44"
                     /tool="antismash"
     misc_feature    13270..13284
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.79"
                     /tool="antismash"
     gene            14158..14820
                     /db_xref="GeneID:96288490"
                     /locus_tag="IE233_RS02190"
                     /old_locus_tag="GCM10010326_04650"
     CDS             14158..14820
                     /codon_start=1
                     /db_xref="GeneID:96288490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031786.1"
                     /locus_tag="IE233_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04650"
                     /product="deoxynucleoside kinase"
                     /protein_id="WP_161247788.1"
                     /transl_table=11
                     /translation="MPVICVGGMIGIGKTSVAELLAKELGSAVFYESVEDNPILPLFYT
                     ASPEEIQAKRYPFLLQLYFLQTRFASIKEAYKQGDNVLDRSIYEDWYFAKVNHDLGRIS
                     SLEMQVYEGLLNEMMREIDGLPYRKAPDLMVYLKADFDTVLHRIGLRGRDFEQDESLVE
                     YYRTLWAGYDDWVHKHYSASDVLVVDMNHTDVVNNPEDAARVVQEVKAALAAAGPRN"
     gene            complement(14977..16089)
                     /db_xref="GeneID:96288491"
                     /locus_tag="IE233_RS02195"
                     /old_locus_tag="GCM10010326_04660"
     CDS             complement(14977..16089)
                     /codon_start=1
                     /db_xref="GeneID:96288491"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015780.5"
                     /locus_tag="IE233_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04660"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_190025992.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.2e-08, bitscore:
                     29.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLHSTYGLTRIINARGPYTPLGVSRSGEGVATAVAAALSEFFVM
                     AELQDVADRALARFAGAEAGTVVHCTASAITLAVAATMTGESAERIAALPDTAGMPRAV
                     VLPAGHAVDYGHSITQAVRLAGAVPVAVGTEEAYTLEDLENGLSRPDVACLLLVSSRLV
                     RGAGAELSEAVAVAHRHGVPVVVDGAAQDFRVDQLLRTGADLVTVSGQKYLGSPTAGLV
                     VGRADPVAAVRAQERGIGRAMKASKEAVVGVLAALEARHGLDMEAWKKQQADKVADFVA
                     RAGALRGVTAAPVSDPTGLPFERARLTVDPAVSRMDAAALESALRSGSPSIWVMPGGRP
                     GAEEVLLELVPLTPAEIDAVLVRLAELLPT"
     gene            complement(16194..17921)
                     /db_xref="GeneID:96288492"
                     /locus_tag="IE233_RS02200"
                     /old_locus_tag="GCM10010326_04670"
     CDS             complement(16194..17921)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288492"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529148.1"
                     /locus_tag="IE233_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04670"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_190025993.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.9e-48, bitscore:
                     159.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.5e-39, bitscore:
                     130.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTVARLFVDALEELGVRQVFGVVGDALNPLTDAIRTSDALSWV
                     GCRHEEAAAFAAGAQSQLTDTLGVCMGTVGPGSVHLLNGLYDAAKSGTPVLAIAGQVPR
                     SEVGTDYFQEVDNDLLFKDVAVFRATVTSPEQLPALLEVAVRTAIGRRGVAVLTIPGDI
                     GDQELPNDRPLRLSVARSENRPDDPALDEAARLIDEGGNVTLLVGRGSRTSRDDVLALA
                     DRLAAPMVLTLKAKEGFEGDNPYQVGQTGLIGNPAAAHAMDHADTLVLLGTDFPYREWY
                     PEGKKVVQVDRVAEHIGRRVPVDVALAADVGPTVRGLLERVAPREDRKHLDSAREKFTH
                     WQDGQRRLAAPGHDKGLIGKVRSAFDNRDHLVRPEALAAAVDAAADDDAVFTSDTGMAT
                     VWLSRFVEMRGSRRLIGSYNLGSMANAMPQAIGAQFLDRDRQTIAFCGDGGLSMLLGDL
                     MTIRTERLPVKLVVFDNRRLGMVKLEQEQAGLPEFGTVLDNPDFAAVAEALGIKGIRVE
                     RAEDLAEAIERTFAEPGPVLLDVLTNPDEIAVPAKPTVQQGWGFAIAKVRENLRSTGS"
     gene            complement(18061..19647)
                     /db_xref="GeneID:96288493"
                     /locus_tag="IE233_RS02205"
                     /old_locus_tag="GCM10010326_04680"
     CDS             complement(18061..19647)
                     /codon_start=1
                     /db_xref="GeneID:96288493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529147.1"
                     /locus_tag="IE233_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04680"
                     /product="FMN-binding glutamate synthase family protein"
                     /protein_id="WP_189762783.1"
                     /transl_table=11
                     /translation="MVRFGAVALLIVCAAAAVTSAFVVSPWWWFAGALLGAIALLGCYD
                     LLQRRHSVLRNYPVLGHARFLLEAIRPELQQYFVERNYDGRPYDRDTRSIVYERAKGVD
                     AEEPFGSERDMYSRGYEFLVPSMRPVDMPKEAPRVRVGGPDCTRPYDMALLNVSAMSFG
                     SLSGNAVLALNTGAARGGFAHDTGEGGLSEYHLRPGGDIIWEIGTGYFGCRTKDGDFDP
                     DKFREKAAHPAVKCVSLKLSQGAKPGMGGVLPGDKVNSEIAQVRGVPEGETVVSPPYHR
                     VFSTPREMVRFLARMRELADGKPVGFKLCPGSRVQFLAVCKAMIAENITPDFIVVDGAE
                     GGTGAAPLEFADHLGMPLTEGLITVHNALVGAGLRDRIRIGASGKVATGSDIVKRLAMG
                     ADWTNAARAMMFAVGCIQAQRCHTNRCPTGVTTQDPRRARALDVADKSERVERFQEATV
                     SSALKIMAAMGVSDPGDLGPHLLRRRATDGDDFRSYAELYEWLKPGELTLDPPAGWGAD
                     WKAADPDSFTG"
     misc_feature    complement(19673..19684)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(19971..19985)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            20063..20803
                     /db_xref="GeneID:96288494"
                     /locus_tag="IE233_RS02210"
                     /old_locus_tag="GCM10010326_04690"
     CDS             20063..20803
                     /codon_start=1
                     /db_xref="GeneID:96288494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152148.1"
                     /locus_tag="IE233_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04690"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190025994.1"
                     /transl_table=11
                     /translation="MRFTSEQHLEDGVRERHFTLGGIPGVLWAPASATPTTPAPLILLG
                     HPPLGLRKMHPRLVARARHSAADGFASATIELPGSGDRPRLPAVEQARAELRRALAAGE
                     PVSDEIVDAVVLPLVDRAVPEWQTALDAVLSLPEIGGPVGYSGGVISIGIRLALVEPRI
                     SAAVLFAGSFVPRAVFEEARQITIPLHVLLQWDDEGNDRQAALDLFDAFGSQDKSLHAN
                     MGGHTGVPQFAGEAAAQFFTRHLK"
     gene            complement(21016..22272)
                     /db_xref="GeneID:96288495"
                     /locus_tag="IE233_RS02215"
                     /old_locus_tag="GCM10010326_04700"
     CDS             complement(21016..22272)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:96288495"
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981693.1"
                     /locus_tag="IE233_RS02215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010326_04700"
                     /product="MFS transporter"
                     /protein_id="WP_190025995.1"
                     /transl_table=11
                     /translation="MTTEPTARSLPRESLGDTHLRRLIVGQGLAAVVDALFLIWLTLFV
                     LKLSEPGMTTGFVLVAVALPRAALLLPAGVLVDRVGPARIAAGAAWLRVAVLLALGALI
                     TLTSPSVATVALLAGLLGAADAAYFPAALALLPAVVPTEKLARVNALVQGAESGGDLVG
                     PAVAAGVIAVVGFDATLGGIAALAALAAVALSMPIRAVRRGERVGDAAGPDEVDGERVS
                     TARALGAGLRYAWREPVVRGMLAAIALINITVVGPVLVGGAVLADQRLGGAGSLGIVLS
                     GFGAGSLAGSLVAGWRPPARRGWTVVGGVAAIGAGMAGLAAVTDVVAATAVVSLIGLGS
                     AFLGVVVVATLQERVPERLLGRVLSLVVLATVAFDPFSYLLAGVLVPFGTRTLFLVCGG
                     AVLACAGLVATSPAIRSLR"
ORIGIN
        1 acggcgacct gcacgacggc gagtccgacc ccgcccgccc cgatgaccac gagccgctcc
       61 ccgggggcgg tgcgggccac cgagcggacg acacggacgg cggtcgtccc tgagcagccc
      121 agaaccgcgg cttcgtcgaa aggcaccgtg tccgcgatcc gaaccagtga gcccgcgtgc
      181 gccaggtagt actcgcacaa cccgccgtcg gagtcgaagc cgaccttcgc cgccgggtcg
      241 gggcagaggt tctccgagcc ctccgcgcac catccgcagt gcccgcaccc ctggtagtag
      301 taggccagga cccggtcgcc gacccggcag gcggctccgt ctcccacctc ggcgacttcg
      361 ccggcgatct cgtgcccgag cacgaggggc agcggcgggg tgagcgccga accgtcggcc
      421 agatgcagat ctgtgtgaca gagcccggcc gcccgcaccc ggatgagcgc ctggccgggc
      481 gcgggtacgg ggcggggacg ggcttcgatc tccaatggct tgcccagtgc gttcagtacc
      541 gcagccgaca tcacaccgct tggcatcgag acctccgtga accgcccgtc gggaacccga
      601 cggcctgcgg aacaagatcc tcacaggccc ggagcaggcg cggcgccacg gccgcgcgac
      661 acgtaccagg attgacgttt ctcttgcctc ccacctgcgg tgatgtcctg cccgccgcgc
      721 ggagattcac ccgttggacg ggctccgagc agctggtacg acatgcagag gtccgaccgt
      781 ccgggccgta gaagcggctc tgacctgctg tttccccgac tcccccgcag cgcgggcgag
      841 caggccggag gggacgggtc cagaacgccg cccagtacgt tccgaaccaa gtggatcacc
      901 ggcagcagag agcgaccctg tggacttcga aacctttcac gacgcctatc cccgcatgct
      961 gcggtggctg atcgaggagc ccgcctaccg caacgcgccc cgcgggtacg ccagccgcga
     1021 gcagctcgga gtcagcttcc ggatcgcgcg ggcggaccag cgggttccgt tcgttccggc
     1081 ccggcggctg aacatcgtct tcaacttcgc cgaggccctc tggtacttgg cgggccggga
     1141 cgacctcgac ttcatcgcgt actacgcgcc cagcatcagc aagtactccg ccgacgggca
     1201 ccggctgacc ggcaccgcct acgggcgtgc gctgttcggc gccgccgagg ggcggcccga
     1261 ccagtggccg gccgtcgtgg agaccctgcg cgaggacccg gactccaagc gggccgtcat
     1321 ccagatcttc cgcggcgagg agctgcaggt gtccggcaac ccggatgtgt cctgcaccct
     1381 gggcctgcag ttcctgctgc gcgaaggggc gctgcacgcg gtgggattca tgcgcgccaa
     1441 cgacgtgtac cggggcatga gcagcgacgt cttctcgttc acgttcctcc aggaggtgct
     1501 cgcccgcgaa ctcggcgtcc cggtcggcag ttacgtgcac caggtcggtt ccctccacct
     1561 ctacgacccc gaccactcaa gggccctgga agtccttgcc gacccggccg ccgacgagcc
     1621 gtcggcctgg agcttccccc tcatgccgga gggcgacaac tggccttatg tgcgcgaggt
     1681 gttggccgtc gaggagcagc tgcggctcgg ccgtcacacg ctcggcgcca cccccgcctc
     1741 gtacgggctg cccgactact ggacgcaggt cctcgtcctc ttcgaggtcc accggcgcat
     1801 ccgcggcaag gagcccgtcg gggaagcgca actgtcgttg ctgtcaccgc tctatcgcca
     1861 cctcgtcgag gagcgctggc cagccatcgc ccccgccccc gtcgcgggct gaaagggaaa
     1921 ccgaccatga caacgagcac gcactggcac tccaccgcct cgatcgccga cggcttcgac
     1981 gcctatgacg acctgcccga gcgcctcatc ggctacccga ccgtcttcgc cgccctcggc
     2041 atcgggtctc ccgacgtccg cactgtcctg gactacggct gcggccccgg gaaggtggcg
     2101 acccgcgtca ccgagatctg cgaggcggac gtcgtggcgg ccgacgtgtc gccgcgcatg
     2161 ctggagatcg cccgcacctg ccgaccgcac ccgcgcatcg actaccgccg gatcgacagc
     2221 ggaaagctca ccttcctcgc cgacggctcc atcgacgcgg ccatgtcctg ctacgtgttc
     2281 atcaacgtcg gtgaactccc gctcctgcac gagatcgccg cagagatcca ccgcgtactg
     2341 cggcccggcg cccgctacgc cgtcctcgac accaatccgg acaccaccgg cgtccgcttc
     2401 tccaccttcc gcaacggcga gcccggccgc acctacgcct gcggtgagcg gcgccaggtc
     2461 ctcctggacc agcccggcgg cggcgaaccg ctggaactcg tcgatcacca ctggccgcgt
     2521 cagacctacc tcgacgtcct cggtgaggcc ggcttcaccg acctcaccgt cgaggagccg
     2581 ctcctcaccg acccctcggc cctgcccggg gcggcgccgg ccgagaccat ccaccctccg
     2641 ttcctcatcg tcacgggagt caagcagtga ccaccactac cgccaccgag tccgttcagc
     2701 agacccacag cgtgttcctc gggggccctt tcaaggccct cgtcgactcc gacggggcca
     2761 tgaacgccgc ggcccgcact cgcttcgagg tcctcatcga gcgcctggaa gcggagggtt
     2821 accacgtcta caacgcccac cgccgcgagt cctggggcgc caagttcctc acccccgacg
     2881 agtgcacccg cctggactac gacgaaatct ccgccagcag cgtcttcgtc gccatcccgg
     2941 gccaccccgc ctcccccggc acccacatcg agatcggctg ggcgtccgcc ctgggcaagc
     3001 cgatcgtcct cctcctggaa gagggagtcg actacgcctt cctcgtccgc ggtctccaca
     3061 cggtcgccga tgtcacctgc ctcaccatcg gcgacaccga ccgcctggcc accgaggtcg
     3121 tcgacgcggt gaaccgcctg gcccgagccg gtgccaacgg ctgacctccg cttgcccgtg
     3181 ggcgcgtacc gaccttgcac ccggtgtctc cccatgcggt ccctcaccgg cccacgactg
     3241 tccgaacgtg ggccggcacg gggttggctt gaacgcctgg tcagaccgtg ggcggccgct
     3301 caacctcgcg gcgtggcagg cagaccggcg ccttgaatcg cgcccgggtt ctgagcgaat
     3361 gcggcgagtg ccgtgaaatc ggtttccagc aggccgagtc gagggtctgt ccggcggagc
     3421 aatgcggtgg ccgagtggtg agcggcgacg aaccgatggt cggccggtcc gatgtcgtcg
     3481 tcgacccagg cgaaggggcg tcctgcggcg tacttcacca ggcagggcgt cttccagaat
     3541 gtcccgtccg gtgaggtctc gcgcagggtg ggccatgtga ccacgggcag ctgcggaagt
     3601 cccaggagcg ggcctatcca ttcattggcg tcagcctccc aggtcgtggc ccacaccagc
     3661 tcgaatcggt ccgcgagcgc cagaagagcg ggtccgtgcg cggggttgag ccagacgcgc
     3721 agcggcttca catatgccct gaggctcgtc ggatgctgag cgatccaccc ttcgggccgg
     3781 agtcgatgtg tccggtagcc gacgggccgg cggtggggct tggccgcgta cgggttcagc
     3841 gggccgtcca cgtcgaggaa cagcagcggc agcggggcgg tcatcaggag ccccctccgt
     3901 ccggtcgcgg gcggttggtg cgtcctgacc ctaccggtac acgcgggaca ccctcttgct
     3961 gatttgcgac cccagccgtc acggccccgc cgaccggatc aacacccccg catcgggccg
     4021 cgcaccatcc cgatgacaca cttgagggac caactccggc tgaacgggta gggacatcga
     4081 acggaccgcg acagatggag aagtacctgt gaccagcgat gagctgcata cccgcatcac
     4141 ccagctggag gcgcagctcg cgcggccgac accgccgccg atcggcggac aggtcagcat
     4201 cccgctcgaa ccgatccgcc accacgccta caccggcgac ggcggcccct gcaccaccag
     4261 cctcttcggc gagcggtgcg ccgaacccgt cgaccaccac gagatccacg accaacaccc
     4321 ctgagcaccg gggcaggtcg gatacgcgac actcacgatg cccgtgccga ctgaacgggc
     4381 gggatgggtt cgaggacccg tcggggtcag tgcgcggacg ggacttgcgt acggtcgcgc
     4441 acaatgatct tgccggtgtt ctcgccgcgc agcatcccca ggaacgcgtc cacgatgtgc
     4501 tcgaagccgt caatgacggt ctcgtccagg gcgagccgac cgctctgcag atgcgggacc
     4561 gcgaatgcgt acaactcctc ttgtacgtca cggtagttgc tgaccaggaa gccctccatg
     4621 cggatgctct tctccacgat gtccgcatag ttgaagcgcg gtgccggcgc accgggggtg
     4681 ttgtactggc tgatcgtgcc gatgcggacg atgcgcccga actcgcgcag cgctcccacc
     4741 gccgcggcca gttgctcgcc gcccacgttg tcgacgaaca cgtcgacgcc ggccggagcc
     4801 accctgccca acaggtcgtg cacgggcccg tcgtggtagt cgaagacggc gtcgtagccg
     4861 acctcccgga cgaggtggac cgccttcgcc gccgagcccg cgctgcccac gagccgtccg
     4921 gcgtggagca gcctggcgaa tcgcccggtc gccgtgccga ccccgcccgc ggcggccgac
     4981 acgaacaggt cctccccctc ctggagccgg gcgatccggg tcaggcccac ataggcggtc
     5041 aggccggtgc cgccgagggt gctcaagtac gcggtcaggg gcaccccgtc gaagcggggc
     5101 agccgccggg tctcgtcagg tgtgatgacg gcgtgggtac gccagccgtg ccggtggaac
     5161 acgatttcgc cctcggccag ccggggcgtg cgcgaggcga tcacccgccc gatggaccgg
     5221 ccctccagcg gcgcgtggag cgcgaagcct ccgggcgcgt cgtccatcag ctcgcggtga
     5281 taggggtcga ccgaccagta gaggttttcc acgagcgcgc tgccgggggc gggatcggga
     5341 atcgtggact ccgcgaagga gaaatggtcg gcggtgggga agccgtgggg gcgggcggtc
     5401 tggtgcacgg tgagcgcggt ctcgttcatg cccggaacct agggcgggaa tggccctcgg
     5461 gtgcagccgg ttgggttcat gcgacgcacc gttccatgag cacttctcat acatcgaggt
     5521 gagcgccccg tggcccgcat gaccggctcc gatctcgtcc agcaggaact gcgtgccctg
     5581 gtggcggtcg cggacaccgg gggcttctcg gccgcggccg aggccctcgg cctgacgcag
     5641 tccgcggtct cccactcggt tcgcggcagc gagcgcaaga tcggcgccgt cctcttcgaa
     5701 cgcggtcgcg ccggtgcccg gccaactccc gccggagagg cggcagttgc gtacgcgcgt
     5761 cgtgtcctgc gcctgctgga cgtcctgacc gccgaggcgc gcggcgccgc gcggcccgat
     5821 gcggcggagg ggccgctccg catcgccgcc ttccgcagcg cggccctcca tctgctgccg
     5881 cccgcgctgc agcggctgcg cgcgcggcat cccgggatcg agccgcgggt gcggatcgta
     5941 cgcgagctgg ggcgcggcac cgccggcgaa gtggccgacg gcagggccga cctggccatc
     6001 gcgacgctcg gcggctccgc gccgctcccc tcgggcctgg tcgccggcga actcctgacc
     6061 gagccctatg ccctggtgca cgcgaagggc cagggcactc cgcgctcgct gccgctggtc
     6121 gactgggcgg agaactgcgg ttcgtacacg cgtcgttggt gggccgcaca ggactggatc
     6181 ccgaaggcaa ccatcgaggc ggaggacgac ggagcagtgc tctctcttgt gagcggtggc
     6241 catggaatgg cgatcatgcc cgcgctctcc ctggccggag caccggactc ggtcgggatc
     6301 accgacctcg gcccggggcg cccgacacgc cgggtcggct tcgtgaccac ctccgaactg
     6361 gcccggtccg ccgtcgtgcg ctccctggtg agagaactcc gagccaccgc ccccgaggcc
     6421 gtcccccatc tcaacaacct tgctctccaa ggccgttgag atgggggtgt tgctggtgac
     6481 gaggcgatgt caggcggcgg aaccgaccct ggcggccagg gacttggcct tctcggccgc
     6541 gtccgcgaga gccttctcgc gggacgcctc cgcgaggggg atcagctcgg acatcgccgg
     6601 gttggacgca gccagcgtca gctccgggac gatgaagtcg acctcggcgc ccagcatttc
     6661 ggacaggagc gcgcccaggt agttctgcac gtactcgaag ggctcgcgcg gggtgcccgg
     6721 agcgtacgag ccgccgcggc tggcgacgac cgtgatcggc agacccttga cggtcgattc
     6781 gggacccgcg gtgcggccca tcaggacgac ctggtcgagc cacgccttga gggtcgaggg
     6841 aatcgtgaag ttgtacatcg gcgcaccgat caggaccgcg tcggcctgct cgagctccgt
     6901 gaccagcttc atgcgctcgg cgaaggcggc cgcctgctcc ggggtgtgcg cggcagggtc
     6961 gacgaacgcg gcggaggcgg cgagaccgtc caggtgcggg acggggtcga cggacaggtc
     7021 gcgatagacg accgtgccct gggggtgctg agcctcccag gccttgcgga aggcatccgt
     7081 caccgcgcgg gatgcggagg ctccagcggg gaacagggac gagtcgaggt gcagcagggt
     7141 ggccatgagg atctcccgaa tggtggcact tttcgtaggc cactagtgat agcacagcta
     7201 cttacttttt ttcaccccct cacaagaggg tagtagtctg aggccatggc ggaccaggaa
     7261 gagcgcgaca gcgggcagcg gcacgagccg gaagcctgcg gccgggtggg cgacggcatc
     7321 acgcaggtct tcgggctgct cggcaagcgg tggacggggc tgatcgtgtc cgccctcacc
     7381 caggggctcg accgcttcac ggatctccgc caggccgtcc cgggcatcag cgagcgcatg
     7441 ctcgcggatc ggctgatgga actcgtggcc gcggggctcg tcctgcgcga ggtggacgag
     7501 ggaccaccgg tgcgggtctc ctaccgcctc accgaatcgg gcgccgcgct ggaaccggcc
     7561 ctcacggaac tggcccagtg ggccgagaag tacctgctca acggcaaggg cagctgctga
     7621 acacactccc gcccgacgcg gcaggcccgc tcccccgagc cccgcggtga ttcattcggg
     7681 gcggccgaac cggtgggccg cccagagcag ggccaggatt ccgacggtca gcaggagggt
     7741 gccctccagg agcacggggg gctgccaccc ggaccactcg acagtcgtgg gggccgcccg
     7801 gtccgggacc cgtgcggcga tgcagcggcg gagcacgtcc accccgtagg ccaggggatt
     7861 ggccgcggcc agtgcctggg cccagcccgg caggttcccg accgggaaga agccgccgga
     7921 caggagcagc agcggcatca tcaccaggcc gagcagcatg ttgaagacct ctggccggtc
     7981 cagggtcacg gccagggtca gcgcgagggc cgtgagggtg aaggaggtca gcatcatgcc
     8041 gacgaggagc gtcagcagca ggagcgggtc gtaggggagc ccgatcgcac cgaccagagt
     8101 gaggagcacc gctccctgca ccgtggcgac gagggtcccg ccggcacagg tgccgaggag
     8161 cagggtgggc cgccggaccg gcgccatcag gagttcacgc acataaccgc tctgccggtc
     8221 ggtgatcaga cggatgccga ccatgatggc cggagtctgg accgtcatca tcagcacgcc
     8281 cgggaagagg tacgtctggt agccgccccc cagcgaggag ttggggatca gggcggccag
     8341 gccgccgccc aggatgaaga ggtagagcat cggctggacc agcatcaggc cggtgtggac
     8401 gggctgggcc gccaggcgca gcaggtcgcg gtggaccagc gcgtggacgg cgcgcagttc
     8461 gtgccacagg cggggcaccc gatcggggcc ggagccgtcg cggaccgcgg gccggtcggg
     8521 tggggaggag gcgtccgagg ccggtagtgc gggtgcggtc atggggcctc ctcgatggcc
     8581 gccggggtgg cggcgggaac catggcggtc ggtgtcccgt gggacggcgg ggcgttgatg
     8641 ctgcgaccgg tgtggtggaa gaacacgtcg tcgagtgtcg gcggggtggc ggaagcggcg
     8701 tgcaccgcga tcccctgggc cgcaagtgcc gcgcacaggc ggggaatcca ggtgctgccg
     8761 tcggggatgc ggagtgatac gccgtcggcg tccagggtga tggcgcgccc ctccggcgcg
     8821 agcccggcga cgacgtgccg ggccgccgcg tcgtcgcccg tgcgcagtgc cacccggtcg
     8881 tcgccgatcg cggccttcag cgccaggggc gtgccctcgg cgacgagccg gccgtggtcg
     8941 atgatgccga gacgatcgca gttctccgcc tcctccaggt agtgggtggt gacgaagagc
     9001 gtgttgccgt gctggtcgcg cagcgcgcgc aggtactccc agatctgggc acgggcgtgc
     9061 gggtcgagtc ctgtggtcgg ctcgtcgagg aacagcacct ggggggcgtg gagcaggccc
     9121 cgggcgagtt ccagtcggcg ccgcatccct ccggacaagg tgcgtacccg ggaccgccgc
     9181 cggtcggcaa ggcccacctt ctccagcgtc tcggtggcac gcaggcgggc gtggcggcgg
     9241 ctcagtccgt agaggcgtgc gtggatgtgc aggttctgtt cggccgtcag atccgagtcc
     9301 agtgcgctct gttggaagag catgccgacc ctgcgccgca cctcgtccgg ctgcctgatc
     9361 acgtcgacgc ccgcaaccgt ggcctgtccc gccgtgggcc gggccagagc gcacagcagg
     9421 gagatggtgg tggacttccc cgcgccgttg gggccgagga aggcgaaggt ctcaccccgg
     9481 tgcacgtcga ggtccaggcc gtgaacggca tgggtggtgg cgccgtccgg gcccgggtag
     9541 ctcttgacca gaccgcgcgt gctgatggcg tacgccgact ggacggcgga cggctccagg
     9601 tccggggacg cggcggtggt cggcggcagg gtcgctcggg tgcgggcctc gtcggcggcg
     9661 tccggctgca tggtcgcgtc ctcgtctacg ggggtggctg ccgcgggcct gcccgccaca
     9721 gcggtcgcgg ctccggccgg tggctgcgaa ggcaaccacc ggccggaggt cttggactag
     9781 gcgcaactga cgccgacgca cacggtgttg agcagggtca gcagaccagt acacgcacag
     9841 gtcccgccga actgtgcctc gtccacgccg atcgggtcgg tctccggaag ggcgtgcagg
     9901 tgcgcaagaa cttcaaggtc ttggttctcc atgactttct ccttctctgt gaggtgctcg
     9961 atgatgtgac gacagggacg atggtgcgca tccctgtcgc tcagcccggc tgctggacca
    10021 tccagtgccg ggggcctgtg tggcgggtcc tgagcaggaa cgccaggatt cccgcggatc
    10081 cgtcgctcca gctcgtcgag acgttcccgt actcgttggg gaagacgacg tggctgttgc
    10141 ggtgggctcg ttcggaagcg atgagtcggg ccaggtcttg ggccatcgcg cggtaggcgg
    10201 gatcgccagt ggcgtcggcc atgtcgagga ggaagtcgcc gttgccggcg agcccgtggc
    10261 actgggtgag ggcggcgcgg gaagcgcgct ccacgactgc tcgggcggcc tggcgggcaa
    10321 ggtcggcgaa ccgcttgtcc ccggtcgcct gccagaggcg gatcaggaac gtgccgatgc
    10381 ccgccgaacc gtggcaccag tacggggccg tgggcacgtc cgtggcctgg gccggccact
    10441 gggccgcctc gccgaccatc acggcgtggg tcaccaggga ctctccggcc gccacggcca
    10501 gctgcatgtg ttcgggccgg ttggagatgg ctgccgcggt gaggaggaag cagccgatgc
    10561 cggccgttcc gtgcgcgaag ccgagatagc gtttgccggc ctcctgggac acggcttccg
    10621 ccggtacggg ccagctcaca ccgggcggct ccacccgtgc cgcggcagcc agccggtcgg
    10681 cgtcggcgac gacccgttcg gccaggcgcg ggtcgcctgt ccggtgccac agatgggcgg
    10741 cggcgagtcc gctgcccgcc gagccgtggg tgatgtcgta gctgggtgtc ggctccagcg
    10801 gggccagggc cagggccacc gcgtggtcca tgagttcacg atcgccgatc gcgcgtccgg
    10861 cgtcgtagag cgcccaggcg gttcctcggc cgccgaagtg caggcccgga cggatggagg
    10921 cggtatcggt gcgggcggcc atccagtgac ccgcggtggc gaggagatcg ggcaggcgtg
    10981 ggtcgccggt ggcctcgaag taccgggtca gggcggtcag tacccctgcc gcaccttgct
    11041 ggacggtgca ggggccggtc tctcccgcct gggtggacac gggccacagt cgacggtcgt
    11101 cggccggatt catcgaatcg accaggtggt tcaccatccc ggtgatcacg atctccgtga
    11161 cgccgtccgg cccttcggtg cgccctgtgg cgacggcggg gcgctccggc cgagcagggt
    11221 tcgccctgcg cagggcctca cgtgccgcgg ccggggtcca tcgctcgccg ggttcgtccc
    11281 tcgtcagccc gaggatcacc tcggtcagga cgtccggcag gctcagcacg tcggcacagg
    11341 ccgcgagcca ctcggcgaac cgctcctgcg cgggcctggt ggccggctcc tccgtgagca
    11401 ggttcgccac cttgcctgcg agtacgaagc acacggtggc gccgaggctg tagtagtcgg
    11461 ccgtccgcga cacgggagcg ccgaccaggc gctcaggggc actgaagcag ggggtcccca
    11521 ccgtggtcgg gagcatgctg tcgccctcca ggacggcgag ctccaggtcg atgaggcgca
    11581 gttcgccgtc ggggcggacc atgacgttgc cgggggtgaa gtccctcagg atccagcctt
    11641 gggcgtgggc cgcgtcgacc aggtccacca ggcgatcgac ctgggcgagc gcgtccgctc
    11701 ggtagcgttc gctcccgacg tcccggtaac gctcggccac ccaggtgtgc aggggaacgc
    11761 ccggtacttc ttcctgggcg aggaacaggt gcccgcccgt ctcgaacatc gcgaccggct
    11821 cgggggcaag gccggtgccc ttgagcttct ccagcgtcgt ggcctcggca cgtaaccagt
    11881 cacggacgtc gccgcccgag gcatcggcct cgacgtgcgg ccgggcttcc ttgatcacca
    11941 ccgctctgcc cgtggtgacg tccgtgcccc ggtagacgcc ccccttgttg gtgtgccgga
    12001 tcgcctcccg taccgagaac cggccgccga gcagcaccgg gctgctcgcc gcggtgtcct
    12061 gctgcggcgg gagcggcacc gaggcgggga acgggctcac cgcccatgac ggcggcgcgt
    12121 actgaccggt tcgtttgtcc tcgaccgggt tgccgtcggg gtcctccatg aaccacacca
    12181 gcagtccgtg ttccgacagc ctgcgccggc cgacgaaggc tccgtagcgg tagtggacca
    12241 ggctgttcgg ggcgtagggc tggtccgaga ggatgcgcgg gccggccagt cccgcggtgg
    12301 ccttgtgcag ttcgagcgcc agtcgggccg cgtcctcgtc ggagggcggg taaacggtga
    12361 tgaacttgcc ggaacttccc cggggcgtgg cccgtgagtt gagcgcgccc acctgttcga
    12421 gcgaccgggc gaacttgaat atcgactctt cccgcagcag cacgcccaaa gccctcacca
    12481 ggacttccgg tgccgacgcg gccgtcgcgg acacatgaag tttccagccc tgctgacgac
    12541 gaataccgga cgggcgcacg aggcggcacc acatctcgtc cacatcggcc gtccaacgct
    12601 cgctcatgcc cgtggcctgc agagtccgac ggagcagaac ttcgagatcg acctcggtcg
    12661 cgtgactcgt catgcgcgtc cctctcaacg gtgaaaaccg ctggtggaat atgccttcgg
    12721 taaggagaaa ggtatagctt gaaaccgctg gaagatactt ggtgcagctg gcgcacggtg
    12781 gcactggggc aatacatggc gcagtccggc gcaaatggag gcgcacggcc gccgacagac
    12841 ggaaataatc catttgttcg acgtttcggc cgcggccaca ggcagtacag gaaatgacga
    12901 gttcaggatc atttctccac ttcgcagcgc ttgttccgtc aaaaaggcca ttgatcgatg
    12961 gacctggcac cagacccgca ggtcaggcca gtgtccatgc accgtccggt caggagcacc
    13021 ggccctccgt cccgcacccc agttcggatc aagcggcgcc ttgatcacca gcatggtccg
    13081 gttgcggcac gagccagggg cacgtcccgc cgacccagct tcgccctcac caggtacccg
    13141 gtaaagggca caatcccgcc acccttccca ccgccgaaag gggcaatcca agccacctgc
    13201 acaaccatga tcgtcagctc gattcaagcc ttcactaaag atattgaatc gtcaacccat
    13261 tccacgtgtt tcatcatttg cgaatgagcc gggctcatga agaactgctt ggacgccaca
    13321 cgcagaacaa acggaacaaa ggaaatacga gtcgactctc gaaacaactc ggtgcggcat
    13381 ttccgcaggc gacccgggtg gttgagccgc aacgtcgaga agctgagcat cgcggccacc
    13441 ccttgcggcg accgcccgct ccgcgcagat acgaagggtg tcatggaatt ccgcacgctc
    13501 ctcgtgcgcc gccaggtcgt gaatcgacca ccgaaggttc tcagtcccct cggggagaat
    13561 gcctcgcgga gaacagcagt tgcccatggg cctctgttct tcgagcgtga cttgcctcgt
    13621 ggtcggctgt gggagacgag tcggctccgg tggcagtcgg gaggtcggtc agcgcggtga
    13681 tgtgtgcgcc gggcgcatcg caccccccgg cggcaaccgc gcgccggctc cgggtgaatc
    13741 cggccaccac gtacgccggt tcaccgcagg gagcagggcc gattagcagc ggccgcttct
    13801 cgtcaggcgc tctgcggctt ccatgccgcc ggggccaggc cgcgccgatc cggtcggacg
    13861 gatcgagcgg gggagccgcg cggacggggc gagcggacgc gtcccgtcgg tcctactccc
    13921 ccggtgtccg cgctcgggcc actcgctttg ctgcccaccc cccgtgcggg cggggcatgg
    13981 gagttcgtca tttatgcttc agggcggcct cggggtggcg ggtccgaaca gtggccacgt
    14041 gacggccgag ctgaacgttc ttggggagtc gactctccgc cgacacgcgt cttcgtcggt
    14101 gcgggacgcg cagcccggcc cgcccgcgag cagagatccc ccggggagaa gtgaggaatg
    14161 ccagtgatct gcgtcggagg catgatcggg atcggcaaga cgagcgttgc cgaactgctc
    14221 gcgaaggagc tgggcagcgc ggtcttctac gagagcgtgg aagacaaccc gatccttccg
    14281 ctcttctaca cggcaagccc cgaggagatc caggcgaagc gctatccctt cctcctccag
    14341 ctctacttcc tgcagacgcg gttcgcctcc atcaaggagg cgtacaagca gggcgacaac
    14401 gtcctggacc ggtccatcta cgaggactgg tacttcgcca aggtcaatca cgacctgggc
    14461 cgcatcagct ccctggagat gcaggtctac gagggcctgc tcaacgagat gatgcgcgag
    14521 atcgacggcc tgccgtaccg caaggcgccc gacctcatgg tctacctcaa ggccgacttc
    14581 gacaccgtgc tgcaccgcat cgggctgcgg ggccgcgact tcgagcagga cgagagcctc
    14641 gtcgagtact accggacgct gtgggccggc tacgacgact gggtgcacaa gcactattcc
    14701 gcgagtgacg tcctcgtcgt cgacatgaac cacaccgatg tggtgaacaa ccccgaggac
    14761 gcggctcgcg tggtgcaaga ggtcaaggcc gccctcgcgg cggccggccc ccggaactga
    14821 atccgttccc aagctcagcg acacccgctc gtcgcccgcg cccgccgcac cacccctgga
    14881 cgtagtccgg ggtcacggcg ggcgcgccct cgcgttccgc aacgtcgcgg ccggtccacg
    14941 cacgccctgg agtccgcccc tcgcggacca agcccgtcag gtgggaagga gttcggccag
    15001 tcggacgagg acggcgtcga tctcggccgg tgtcagaggc acgagttcga gcaacacctc
    15061 ctccgcgccg ggccggccgc ccggcatgac ccagatcgat ggtgagcccg accgcagcgc
    15121 gctctccagg gccgcggcgt ccatgcgcga aacggcgggg tccaccgtga gccgggcgcg
    15181 ttcgaagggc agcccggtcg ggtcggagac gggcgcggcg gtgactcccc gaagggcacc
    15241 ggcccgcgcg acgaagtccg ccaccttgtc cgcctgttgc ttcttccagg cctccatgtc
    15301 cagtccgtgt cgcgcctcca gcgcggcgag gactccgacg acggcctcct tgctcgcctt
    15361 catcgcacgg ccgatacccc gttcctgcgc ccgcaccgcc gccaccggat ccgcccggcc
    15421 caccacgagg ccggcggtcg gcgaccccag gtacttctgt ccgctgacgg tcaccaagtc
    15481 cgcacccgta cgcagcagtt gatcgacgcg gaagtcctgg gcggcgccgt cgacgacgac
    15541 gggcaccccg tggcggtgcg cgaccgccac cgcttcggac agctcggcac cggccccgcg
    15601 taccagacgg gaggacacca gcaacaggca cgcgacatca gggcgcgaga ggccgttctc
    15661 caggtcctcc agcgtgtacg cctcctcggt gcccacggcg accggaacag cacccgcaag
    15721 ccgaacggcc tgcgtgatgg agtggccgta atcgaccgcg tggcccgcag gcaggacgac
    15781 ggcgcggggc atcccggccg tgtccggcag ggccgcgatg cgctccgcgg actcccccgt
    15841 catcgtggcc gcgaccgcga gggtgatcgc ggacgccgtg cagtgcacca ccgtccccgc
    15901 ctctgccccg gcgaaccggg cgagcgcgcg atcggccacg tcctggagtt ccgccatgac
    15961 gaagaactcc gacagggccg cggcaaccgc cgtggcaaca ccctccccac tgcgtgagac
    16021 gcccaacggg gtgtacgggc cccgcgcgtt gatgatccgg gtgagtccgt aggtggagtg
    16081 aagtcccatg gacgacatcc tgcctggctg acgggatcaa gtccccgacg ggggtgcccg
    16141 gttgatccac cgcggggttc cgcccggctg ccggggctgc cgggctgtcg ggctcaactc
    16201 cccgtgctgc gcaggttctc acgcaccttg gcgatggcga agccccagcc ctgctggacg
    16261 gtgggcttgg ccgggacggc gatctcgtca gggttggtga gcacgtcgag gaggacggga
    16321 ccgggctcgg cgaaggtgcg ctcgatcgcc tcggccagat cctcggcgcg ctccacgcga
    16381 atgcccttga tgccgagcgc ctcggcgacc gccgcgaagt ccgggttgtc caggacggtg
    16441 ccgaactcgg gcaggccggc ctgctcctgt tcgagcttca ccatgccaag gcgccggttg
    16501 tcgaagacga cgagcttgac gggcagtcgc tcggtacgga tcgtcatcag gtcgccgagc
    16561 agcatcgaca ggccgccgtc gccgcagaac gcgatggtct ggcggtcgcg gtccaggaac
    16621 tgcgcgccga tggcctgcgg catcgcgttg gccatggacc ccaggttgta ggagccgatc
    16681 agccgtcggc tgccgcgcat ctcgacgaag cgggagagcc agacggtggc catgccggtg
    16741 tcggaggtga acacggcgtc gtcgtcggcc gcggcgtcca ccgcggcggc gagcgcctcg
    16801 gggcgtacga ggtgatcgcg gttgtcgaag gcggaacgga ccttgccgat caggcccttg
    16861 tcgtggccgg gtgcggcgag cctgcgctgg ccgtcctgcc agtgcgtgaa cttctcgcgc
    16921 gcggagtcga ggtgctttcg gtcctcgcgg ggggcgacgc gctccaggag gccgcgcacg
    16981 gtcgggccga catcggcggc gagcgccacg tcgacgggca cgcgtcgccc gatgtgctcg
    17041 gccacgcggt ccacctggac gaccttcttg ccctccgggt accactcccg gtacgggaag
    17101 tcggtgccga gcaggaccag cgtgtccgcg tggtccatgg catgggcggc ggccgggttg
    17161 ccgatcaggc cggtctggcc gacctggtag gggttgtcgc cctcgaagcc ctccttggcc
    17221 ttgagggtga ggaccatggg tgcggcgagc cggtcggcga gggcgaggac gtcgtcgcgc
    17281 gaggtacggg aaccgcggcc gacgagaagg gtgacgttcc cgccttcgtc gatgaggcgg
    17341 gcggcctcgt cgagggccgg gtcgtcggga cggttctcgg aacgggcgac ggagagccgc
    17401 agcggccggt cgttgggcag ctcctggtcg ccgatgtcgc cggggatggt caggacggcg
    17461 acgccccggc ggccgatcgc ggtgcgcacg gcgacctcga ggagggcggg gagctgctcg
    17521 ggcgaggtga cggtggcgcg gaagacggcg acgtccttga agaggagatc gttgtcgacc
    17581 tcctggaagt agtcggtgcc gacctcggag cgcggcacct gcccggcgat ggcgagcacg
    17641 ggcgtgccgc tcttggccgc gtcgtacagg ccgttgagca ggtgcaccga gccggggccg
    17701 acggtgccca tgcagacgcc cagggtgtcg gtgagctgcg actgggctcc ggccgcgaac
    17761 gcggcggcct cctcgtggcg gcagccgacc caggagaggg cgtcggaggt ccggatggcg
    17821 tcggtgagcg ggttgagcgc gtcacccacg actccgaaga cctgccgcac tccgagttct
    17881 tcgagggcat cgacgaagag gcgggcgacg gtgcgggaca tggaggggtg tcctttctgt
    17941 ggggccggcc cgcggggcgt ggcccgcggt tcttcagtgg tcggggcgtc gggtccgtac
    18001 atccggtgcg cccggcgcgg atggttcaaa caggatgggg caaaggggac tgccgagcgg
    18061 tcagccggtg aagctgtccg gatcggctgc cttccagtcg gcgccccacc cggcgggcgg
    18121 gtcgagggtc agctcgccgg gcttcagcca ttcgtagagc tccgcgtagg agcggaagtc
    18181 gtcgccgtcg gtggcgcggc ggcgcagcag gtgcgggccg aggtcgccgg ggtcggagac
    18241 ccccatcgcg gccatgatct tcagggcgct ggagacggtc gcctcctgga agcgctcgac
    18301 ccgctcggac ttgtccgcga catcgagggc tcgggctcgg cgcgggtcct gggtggtgac
    18361 gccggtgggg cagcggttgg tgtggcagcg ctgcgcctga atgcagccga cggcgaacat
    18421 catggcgcgg gcggcgttgg tccagtcggc gcccatggca aggcgcttga cgatgtcgga
    18481 gccggtggcc accttgccgc tggcgccgat ccggatgcgg tcgcgcagtc cggcgccgac
    18541 cagcgcgttg tggacggtga tcagcccttc ggtgagcggc atgcccaggt ggtcggcgaa
    18601 ctccagcggg gccgcgccgg tgccgccttc ggcgccgtcg acgacgatga agtcgggggt
    18661 gatgttctcc gcgatcatcg ccttgcacac ggcgaggaac tgcacgcggg agccggggca
    18721 gagcttgaag ccgaccggct tgccgtcggc gagctcgcgc atccgggcca ggaaccgcac
    18781 catctcgcgc ggggtggaga agacgcggtg gtacggcggt gagacgaccg tctccccctc
    18841 ggggacaccg cggacctggg cgatctcgct gttgaccttg tcgccgggca gcactcctcc
    18901 catgccgggt ttggcgccct gggagagctt gagggagacg cacttgacgg ccgggtgagc
    18961 ggccttctcg cggaacttgt ccgggtcgaa gtcgccgtcc ttcgtacggc agccgaaata
    19021 gccggtgcct atctcccaga tgatgtcgcc gccgggacgc aggtggtact cggagaggcc
    19081 gccctcaccg gtgtcgtgag cgaaccctcc ccgtgcggcg cccgtgttga gagcgaggac
    19141 ggcgttgccg gagagggagc cgaagctcat cgcggagacg ttgagcagcg ccatgtcgta
    19201 cggacgcgtg cagtcggggc cgccgacccg cacccggggt gcctccttcg gcatgtcgac
    19261 cggacgcatc gacggcacca ggaattcgta gccgcggctg tacatgtcgc gctcgctgcc
    19321 gaagggctcc tcggcgtcga cgcccttggc ccgttcgtag acgatgctgc gggtgtcgcg
    19381 gtcgtagggg cggccgtcgt aattgcgttc cacgaagtac tgctggagct cgggacggat
    19441 cgcctcgagg aggaagcggg cgtgccccag aacgggatag ttgcgcagga ccgaatggcg
    19501 ccgctggagc aggtcgtagc atccgagcag ggcgattgcg ccgagcagag ccccggcgaa
    19561 ccaccaccac ggcgagacga cgaacgccga ggtcaccgct gcggctgcac acacaatgag
    19621 tagggccacg gccccaaatc gcaccatgga tgaccggata tccgggatcg aggcattcat
    19681 gtacgcccag gaccttcgct cccgcctcgg actcggccga ggacttcacc ggttgcgtat
    19741 cccgctaccc ccgggccatc ggggcacgct ccctggggac ggtgtgttgg ggcggtgttg
    19801 ttgcagaggc cgacgaaccg ccatcggcgc ccggtccggg tcggaccggt tcgccgccgc
    19861 ccactcctgg ccggccgcac tctcaataac cggttggaga ccaggtcggc cactgctacg
    19921 ttctcggagg ccgtgcgaga catcgaggag gtggtacccg tgaacgcagt atcgacacgg
    19981 gtgctcccct ccggggtcat ggtcgggcga tagtcaggtc gtccgggagc gccgttccag
    20041 tgcactcccg aaaggcaaga ccatgcggtt cacttctgaa cagcacctcg aagacggcgt
    20101 ccgtgagcgc catttcaccc tcggtgggat ccccggcgtc ctgtgggccc ccgcatccgc
    20161 caccccgacc acaccagcac cactgattct gctcggccac cctcccctcg ggctgcgcaa
    20221 gatgcacccg cggctggtgg cccgggcccg gcactccgcg gcggacggct tcgccagtgc
    20281 caccatcgag ctccccggaa gcggtgaccg gcctcgtctg cccgccgtcg agcaggcccg
    20341 ggccgagctg cgccgggcgc tggcggccgg cgagccggtc agcgacgaga tcgtcgacgc
    20401 cgtcgtcctc ccgttggtcg acagggcggt cccggagtgg cagaccgcgc tggacgcggt
    20461 cctgtcactg cccgagatcg gcggcccggt cgggtactcg ggcggagtga tctccatcgg
    20521 catccggctc gcgctggtcg agccacgcat ctcggccgcc gtcctgttcg ccgggagttt
    20581 cgtgcctcgc gccgtgttcg aggaggcccg gcagatcacc attccgctgc acgtcctgct
    20641 gcagtgggac gacgaaggca acgaccgcca ggcagccctg gacctgttcg acgccttcgg
    20701 ctcccaggac aagtccctgc acgccaatat gggcgggcac accggcgtcc cgcagttcgc
    20761 aggggaagcc gccgcccagt tcttcacccg gcacctgaag tgaggccagg ccgacggacc
    20821 ggtagcacgt agcggctgat ggcggcaggc cgaccacccg tcgagggcgc tttcctgccg
    20881 ccgtcaccgc tcagtaccgc gcgggcctct gctgattctc ggcgggggcc cgcgctgcgg
    20941 ccgcatgccg cggtgtgcgg ctgggcccag tcacccttgt tcccgtggcc gctcgcccct
    21001 cgcccacacc tccggtcagc gcagagagcg gatcgccggg ctcgtggcca ccaggccggc
    21061 gcacgccagg acggcgccgc cgcacaccag gaacagcgtc ctcgtgccga aggggaccag
    21121 aacaccggca agcaggtagg agaaggggtc gaaggccacc gtggccagga cgacgaggct
    21181 gagcacacgg cccagcaatc gctccggaac ccgctcctgc agggtggcca cgacaaccac
    21241 tccgaggaac gcggacccga ggccgatgag cgagacgaca gccgtggcgg ccacgacgtc
    21301 ggtgacggcc gccagtccgg ccatgcccgc gccgatcgcc gctaccccgc cgaccacggt
    21361 ccagccgcgc cgagcgggcg ggcgccaccc ggccacgagt gaaccggcca gcgaaccggc
    21421 accgaaaccg gagagcacga tgcccaacga cccggcgcca ccgaggcgtt gatcggcgag
    21481 caccgctccg cccacgagca cgggacccac gaccgtgatg ttgatcagcg cgatcgccgc
    21541 cagcatcccc cgcaccaccg gctcgcgcca cgcgtatctc aagcccgcac ccagggcacg
    21601 cgcggtgctg acccgctcac cgtcgacctc gtccggcccg gcagcgtccc cgactcgttc
    21661 gccacgccgc accgcccgga tgggcatgct gagggcgacg gcggccagcg cggccagcgc
    21721 cgcgatccct ccgagcgtcg cgtcgaagcc gacgacggcg atgactccgg cggccaccgc
    21781 ggggccgacc agatcgcccc ccgactccgc gccctgcacg agcgcgttga cccgggcgag
    21841 cttctcggtc ggtacgacgg cgggaagcag tgcgagggct gcggggaagt acgcggcgtc
    21901 ggcggcaccg agcagtccgg cgagcagtgc gaccgtcgcc accgatggcg aggtgagggt
    21961 gatcagagcg ccgagggcga gcaggaccgc gacccggagc caggccgcgc cggccgcgat
    22021 acgggcggga ccgacgcggt cgaccagcac gcccgcggga agcaggagtg ccgcacgtgg
    22081 cagtgccact gccaccagga cgaaacccgt ggtcatcccg ggttccgaca gcttcagcac
    22141 gaagagcgtg agccagatga ggaacagcgc gtcgaccacg gccgccaggc cctggcccac
    22201 gatcagtcgg cgcaggtgcg tgtcgccgag cgattcgcgc ggcagggatc gggcagtcgg
    22261 ctccgtcgtc atcgcccgct ccccgcggcg ccatctggat cgccaccgtg cggaaagcgg
    22321 tcgactacgt ggctgtgggt gcacaacttc cttgcagtgg ctcccagttg acgggtgagc
    22381 tcaatacccg cgtcgtcacc cccaccaagt ccgcacccgg ctgaacccgg acggtcggga
    22441 ccgcccctca ctccgatcga caactggaac acatccactc gcttccgatg ggacgcgctg
    22501 cgtcggcaga ctcaccctgc ctgtcactag gcgatgtgcg tacctccgtc gaccgtcagg
    22561 gtggtgccgg tgatgtagga cgacgcgtcg gacaccagga agaccagggc cgcggcgagc
    22621 tcctcgggct gcccgacgcg gcccgcgagc acccgcggca tcatcgcttc gag
//
