LOCUS       NZ_BMUT01000018        21224 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces hiroshimensis strain JCM 4586 sequence18, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUT01000018
VERSION     NZ_BMUT01000018.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces hiroshimensis
  ORGANISM  Streptomyces hiroshimensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 116984)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 90X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650335.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:32:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,830
            CDSs (total)                      :: 6,745
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 25 of 125
            Pseudo Genes (incomplete)         :: 107 of 125
            Pseudo Genes (internal stop)      :: 4 of 125
            Pseudo Genes (multiple problems)  :: 11 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 57994
            Orig. end                         :: 79218
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUT01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21224
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21224
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21224
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11224](-)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11224)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            complement(240..860)
                     /locus_tag="IE241_RS30530"
                     /old_locus_tag="GCM10010324_62280"
     CDS             complement(240..860)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE241_RS30530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010324_62280"
                     /product="hypothetical protein"
                     /protein_id="WP_190025098.1"
                     /transl_table=11
                     /translation="MDINMKSKALRRTTTAVVSAATAAAVMATLAPAAQAAEPAEKSTV
                     KAAQKARYTDEEIVGLFTLGSGRAATEHPEVLKKFGIPQQKVDAARVASLTSALRKTDP
                     AFHQAVTQNVQSGNPYKVEKALTTLSADVQAVSNGKGNRADAVALGSWWFKTQQAVVQT
                     GTVATTVAAVAEVGVVFVVAYRSADDTSQFTKQAMAASVARAL"
     gene            1063..1989
                     /locus_tag="IE241_RS30535"
                     /old_locus_tag="GCM10010324_62290"
     CDS             1063..1989
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE241_RS30535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010324_62290"
                     /product="hypothetical protein"
                     /protein_id="WP_190025099.1"
                     /transl_table=11
                     /translation="MDQVVRRWAPVGFLLGTAWLAGALVVPQVWSVGVVWAWAAGWGGL
                     VAALVAGSAAMVALLFAAGLPARGMAPTPRTLPRQLGWAITVFLVGSAGVALGYLARRS
                     GDIGLGGDATLFLWCGVPYAAAAALSVPGRAVRAAAGTAIACTAAFLAWSGDQAHRSEE
                     LASLLKDSPLPRERLLLPEAPDGYEIDEDNGSISSRGFSLGYRYAGRGKVRQTIQYEVS
                     PGDVSPCADDRRPGPATCTDLGGGFTSAARTLGDGSPSTALALRRDGVTLTVTVYERVD
                     ISELRRMLERVHPAGDDELLLALRFTP"
     gene            2136..4565
                     /locus_tag="IE241_RS30540"
                     /old_locus_tag="GCM10010324_62300"
     CDS             2136..4565
                     /GO_function="GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042888.1"
                     /locus_tag="IE241_RS30540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62300"
                     /product="Orn/Lys/Arg decarboxylase N-terminal
                     domain-containing protein"
                     /protein_id="WP_190025100.1"
                     /transl_table=11
                     /translation="MADGTVLFAVREHSGGGSTTAEQLRRIHKELEDSGYEVRWASTSE
                     DARAVLRTEAGLAAAVVDWDLPGSSGDDGREDDKDDGEPGGADVLRQAGRRFRNLPVFL
                     VTAGEDLDHLPLWVAEAVVGYIWPLEDTAPFIAGRIARAARGYQEDLLPPFFKAMRRFD
                     DTHEYSWHTPAHAGGVAFLKSPVGRAFYDHFGERLLRSDLSISVGDLGSLFEHTGPVGA
                     AERNAARIFGADRTYFVLHGDSTCDRMVGHFSVTRDEIALVDRNCHKSVLHGLVLSGAR
                     PVYLVPTRNGYGLAGPLPPAEIQAQSVASRIARNPLTPGAVSPDAQYAVLTNSTYDGLC
                     YDSLQVARALAPSTPRLHFDEAWFAYARFHPLYAGRYGMAVGPDTFPGPERPTVFSTQS
                     THKLLAALSQSAMVHVKPAPRAPVEHERFNEAFMMHGTTSPLYPMIASLDVAAAMMDGP
                     QGRWLIDEALAEAVRFRQTVVRIGRRIAAAGDRPGWFFGVWQPETVTDPATGEQVPFAD
                     APAELLRTDPSCWQLEPGADWHGFPGLTEGYCLLDPVKVTLTCPGIDASGRMSDWGIPA
                     RVLTAYLATRNIVVEKTDSYTTLILFSMGITKGKWGTLMDGLMDFKTLYDEDAPLERVL
                     PELVEAHPQRYTGGTLRGLCQEMHDHLRETDLVELLDTAFQDLPEPVTPPQHCYQRLIR
                     GGTERVRLADAAGRVAAAMVTVTPPGIPVLMPGENTGTPDGPLLRYLKALESFDRRFPG
                     FHSEAHGVTLDPDSGDYLIECVRRIPAQQAGDAAGGEAASGEGAAGEAASVRVSDA"
     gene            complement(4552..5148)
                     /locus_tag="IE241_RS30545"
                     /old_locus_tag="GCM10010324_62310"
     CDS             complement(4552..5148)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742203.1"
                     /locus_tag="IE241_RS30545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62310"
                     /product="HAD family phosphatase"
                     /protein_id="WP_190025101.1"
                     /sec_met_domain="HAD_2 (E-value: 1.9e-29, bitscore: 95.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPDLAPRNAACLLFDWDGTLVDSQYTNYRAMAAALRQEGIELAQ
                     DWFDARTGLSSAEMIRTLLDERGLSLARPVEQVVAARDALFLEEAHTVRPHAAVLAVVE
                     AMKHRLPMAVASGGARHIIETTLKHQPFHDAFQALVTRDDVERGKPAPDIFLAAAEALG
                     AHASRCLVYEDSDEGIAAAHAAGMTVIDVRPFTRR"
     gene            complement(5157..6524)
                     /locus_tag="IE241_RS30550"
                     /old_locus_tag="GCM10010324_62320"
     CDS             complement(5157..6524)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0051119 - sugar transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00879.1"
                     /locus_tag="IE241_RS30550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62320"
                     /product="sugar porter family MFS transporter"
                     /protein_id="WP_229900065.1"
                     /transl_table=11
                     /translation="MTHAPVTQGDVQPSPLRVFTVLLTSLGGLLFGYGTGVIAGALPLV
                     SHTYGLSSWSQGAAVSAALLGAALTAPTSGRLADRLGRRPVLGGATAFYAAGTLLSATA
                     EGTAALLAGRLLVGLALGATSFAVPLYISEIAPPARRGALVTLNQLMITVGLLLSYVVA
                     YVLEPSGNWRTMFALGAAPALILLAGLPFVPESPEWLHSRGRTERAAREAHRLGLPASA
                     ADSTPSATRGLSLRAAAAHAGPRWVALGLAIAVLVHLTGLNTAIYYAPTILASSGLTSS
                     GGVAGSVLVGSCNVLATVFTIVFLDRWGRRPLMLGGLAVMAAAAVAIAGVQSLGDPGVA
                     TAVLLCLFITAGAVGPAAVFWVYIAEIYPARARGALMSLATAAHWAADFVVATTFLPLV
                     QGLSLEGAFLVYAVITAASAVGLGRWMQETKSAPVSASVSQAPAATPPTLPLETER"
     gene            complement(6521..7576)
                     /locus_tag="IE241_RS30555"
                     /old_locus_tag="GCM10010324_62330"
     CDS             complement(6521..7576)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742205.1"
                     /locus_tag="IE241_RS30555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62330"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_229900067.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 5.4e-24, bitscore:
                     78.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 2.7e-27,
                     bitscore: 88.1, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAPTPTPAPAALRWGVLGATSYIATHLMPAIAGTPGCELTAVA
                     SRPGRTEQAATAGEPFGAAAHPDYASLLADPAVDAVYIALPNTDHVEWTVRALEAGKHV
                     LVEKPMAMDEKGCARIEAAAEASSRTVMEAFMYRFHPQQARAAELLASGAIGELRVVRA
                     SFAFGIETGSGNIRLDPALGGGATWDVGCYAIDVPLFFFGQAPADVSARFSRRPGLGVD
                     TSAVATMDFGRGRSAVVDYSIDYGPRAWYELQGTHGTITVRNAWAMSGEDGVITVLTAD
                     GIREETVPAANHYQLQVAHFAEAVRTGASALRVPLADSRRTARVGEALVASAAAGGTAV
                     ACGGDESTAPR"
     gene            complement(7573..9144)
                     /locus_tag="IE241_RS30560"
                     /old_locus_tag="GCM10010324_62340"
     CDS             complement(7573..9144)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742206.1"
                     /locus_tag="IE241_RS30560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62340"
                     /product="GMC family oxidoreductase"
                     /protein_id="WP_190025102.1"
                     /transl_table=11
                     /translation="MKTDGVHGADGTYDVIVVGAGAAGSIVAARLSEQRDRSVLLLEAG
                     PADDDPRIARPASWPFLLGSELDWKYRTVPQAALSGRRLAWPRGRVVGGSGAVNAMVHV
                     RGAASDFDAWARWGGAMWDAQHVMPYLEALEGPAGAPEYGRIPVAENTAPHPFAAAFVA
                     AAEKYGLPSNPDFNSGVQEGVGLYRTTRTDDAASGPGRTTPAAPARRGNTAHTHLRPAL
                     DRPNLTLLTGATVTAVEVENGRAAGVRILREGRVTTVRCAGEVILCGGAVASPQLLLLS
                     GIGPAAGLTALDIPVVTDLPGVGANLHDHVQVSLAYDTTEGHPVADFSNLGEAGGFVTL
                     YPGSPAPDVQLSFAPMKDLNNGSELGHGFTVGPGVTRPRSRGSLTLASADPTAHPLIDP
                     RYLSDPHDLDTLVEGVRIARDIAATAPLADFATGGPLSPAATRRELEDFVRANAQTQFH
                     PVGTCRFGQEADGMAVVGPRLAVRGVAGLRVADASVIPNMITGNIHAAVAAVAERAAEF
                     VQEDLA"
     gene            complement(9249..10004)
                     /locus_tag="IE241_RS30565"
                     /old_locus_tag="GCM10010324_62350"
     CDS             complement(9249..10004)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-122). E-value: 6.1e-15. Score:
                     47.5. Matches aSDomain:
                     nrpspksdomains_IE241_RS30565_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="IE241_RS30565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62350"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_190025103.1"
                     /sec_met_domain="adh_short (E-value: 7.6e-37, bitscore:
                     119.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2e-36, bitscore:
                     119.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDRVPVVLVTGASAGIGREAAAAFAEAGMTVVLAARNEERGHR
                     AAEEIRAGGGKAQFFRCDVTEPEDVRELFARITVTYGRLDYAFNNAGVPGDGRLVDVSE
                     EDFDRAFSVNTRGLWLCLREELRLMAEQGHGSIVNNTSVHGLRTVFPGIGAYVASKHAA
                     VALTRVAALEHARDGVRVNALAPGPIETEMLAASEAAVGGATTWRGLIPSGEIGTPRQV
                     ADVAMWLFSPASSYVNGQTIGVDGGFLAV"
     aSDomain        complement(9639..9983)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE241_RS30565_PKS_KR.1"
                     /evalue="6.10E-15"
                     /label="IE241_RS30565_PKS_KR.1"
                     /locus_tag="IE241_RS30565"
                     /protein_end="122"
                     /protein_start="7"
                     /score="47.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVLVTGASAGIGREAAAAFAEAGMTVVLAARNEERGHRAAEEIRA
                     GGGKAQFFRCDVTEPEDVRELFARITVTYGRLDYAFNNAGVPGDGRLVDVSEEDFDRAF
                     SVNTRGLWLCL"
     CDS_motif       complement(9891..9983)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE241_RS30565_0001"
                     /evalue="4.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE241_RS30565"
                     /protein_end="38"
                     /protein_start="7"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VVLVTGASAGIGREAAAAFAEAGMTVVLAAR"
     gene            complement(10001..11224)
                     /locus_tag="IE241_RS30570"
                     /old_locus_tag="GCM10010324_62360"
     CDS             complement(10001..11224)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742208.1"
                     /locus_tag="IE241_RS30570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62360"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_190025104.1"
                     /sec_met_domain="salQ (E-value: 1.7e-146, bitscore: 480.6,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 9.5e-63, bitscore:
                     204.6, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSAPRSQTWQVRSQQAVSYEIVETRGLLDPRNDALLAVPGGGRA
                     AGTRLVVLDHSIDALYGTRIRNYFAHHDAAVEYLTIRGAEENKNIEQVMQVADKLNEIG
                     THRLSSPPLVIGGGVVADVVGLAASLYRRGIPYVRVPTTLLAQVDVSVAAKTGINYGGY
                     RNRLGSYSPPPRTLIDREFLATVPERELRNGMGEIFKMALIKDRRLFELLETYGAALIS
                     SRFQDPAAGDDGVEGVAGEIADEVIGRAIAGMAGELEPNLWEKNLERSVDYGHSFSPLV
                     EMRAIPELLHGEAVAMDCVFSAVIAANRELIRAEDLRRIVAAARRLGLAPSHPLFCDTD
                     LVLEALEDTVRHRDGRQNLPMLTGIGEVCFLNDVTEVEIKQACDAMADLLDGPRDAASP
                     VSAAGAQR"
     misc_feature    complement(11114..11116)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11354..11369
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            11609..11950
                     /locus_tag="IE241_RS30575"
                     /old_locus_tag="GCM10010324_62370"
     CDS             11609..11950
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE241_RS30575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010324_62370"
                     /product="hypothetical protein"
                     /protein_id="WP_190025105.1"
                     /transl_table=11
                     /translation="MNVATAEGLLHLIAAEPTLLASAPADPDESDLHLRARDGGHLCLG
                     CGQPARCAVVVNADVHGPRWLDLCSPCWQTVRTANVLCGEAEGGEGPGNAGGPENAGGP
                     ENGDGQARS"
     gene            complement(11935..12429)
                     /locus_tag="IE241_RS30580"
                     /old_locus_tag="GCM10010324_62380"
     CDS             complement(11935..12429)
                     /GO_function="GO:0072570 - ADP-D-ribose binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140205.1"
                     /locus_tag="IE241_RS30580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62380"
                     /product="macro domain-containing protein"
                     /protein_id="WP_190025106.1"
                     /transl_table=11
                     /translation="MPSEIIYERGDATAPRGSGPRVIAHVCNDSGGWGRGFVLALSRRW
                     RAPEAAFRRWYRDRQRNDFGLGAVQYVEVEPGLWVANMVGQHGIRTAAERAAGIGVPVR
                     YEAIDAALASLGDKALALGASVHMPRIGCGLAGGRWEMVEPLVTRRLTGRGVPVTVYDL
                     A"
     gene            12605..14482
                     /locus_tag="IE241_RS30585"
                     /old_locus_tag="GCM10010324_62390"
     CDS             12605..14482
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982328.1"
                     /locus_tag="IE241_RS30585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62390"
                     /product="hypothetical protein"
                     /protein_id="WP_190025107.1"
                     /transl_table=11
                     /translation="MSTQEERSALTPRTSLYAYALRLHDAEPDGSLPRGGYRLPDPDPA
                     PATTPPTATAPPQRPGSIDRAEAQAAATDAVIPLLTEPDTVRAADEVHRRLHALGVGVS
                     HVRHAFTELPLEDEAAARALGRRLVRTGTSAPAVSVGLGLLTRLGEPEDVPYLKVLGLF
                     RTFTRPAITALTSIDCPAAALVWLSRYTEGRELRRLVDALLAHDDQAARAGLLSVSLDP
                     RAVGSETARRIAEAVMLDDIISDDPVDTRTLAQAGRLLSRMAGAGTYQPEILAYDRAVA
                     AYEAFVTGAYRLPPGLDHYAILLSVALDLHSGPSVLLDWRPGRREALLDTLESVLSAPA
                     WAAVPTDPGLTDPDLTDPADRRRVRWIRRAAPQPFTRPEAPGRLRVEVVVRDPADREPV
                     ETRLLIDGRPLVPEAFGRGPAHAPEYLLHTGRLRATAEPQEVQLAEAYCTEGCCGALYV
                     TIRRDGDHVVWSDWRRPGTLPSGQPAPGLPEYRFDAPACDAEIARAENDHSWAWPARNA
                     ARLITAGLRERPGILARWDARMDWVGTGFHDPDTVAVSFTFRPGIAAGRQDKDGHSLQF
                     IWDFPDDGTPPEEQAAAALHRLSTQDPKGYAEVRGGSRESAEALGYPWP"
     gene            complement(14528..15136)
                     /locus_tag="IE241_RS30590"
                     /old_locus_tag="GCM10010324_62400"
     CDS             complement(14528..15136)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577777.1"
                     /locus_tag="IE241_RS30590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62400"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190025108.1"
                     /transl_table=11
                     /translation="MPKQVDHRERRETIARALWRVVEQRGVAHLTMREVAQEAGISHGA
                     LQHYFASRGAMLSFAMDFAAEQTSLRVGRGLQELGDRPHPRDVLRLMLTETLPLHADAR
                     ATSRMSAAYVLEALHDEDVHARARDGLLQGRALVEQLIRQAIADGHIPPDRDPATETNL
                     LLALTGFTPLIELDVIDTRDVLTAVDQYLDRLFTGEGQQ"
     misc_feature    15162..15178
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.34"
                     /tool="antismash"
     misc_feature    15166..15180
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.06"
                     /tool="antismash"
     misc_feature    complement(15167..15180)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.08"
                     /tool="antismash"
     misc_feature    15179..15195
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.49"
                     /tool="antismash"
     gene            15239..16780
                     /locus_tag="IE241_RS30595"
                     /old_locus_tag="GCM10010324_62410"
     CDS             15239..16780
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130279.1"
                     /locus_tag="IE241_RS30595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62410"
                     /product="carboxylesterase/lipase family protein"
                     /protein_id="WP_190025109.1"
                     /transl_table=11
                     /translation="MPAAEQPCVRTTEGVVRGRLRQGHAVFRGIPYARPPVGALRFAAP
                     APPAPWEGTREAAEFGPSVPQSGPARAIPPEGAEGVEGVEDTDDTEGMDWLTLNVCTPD
                     PGAAGLPVLVWIHGGAYIAGASSDPMYEPAALAGAGLVVVSINYRVGAEGFAFLEGAPA
                     NRGFLDQIAALQWVQRNIAAFGGDPGCVTVAGQSAGAGSVAALLTMKAARGLFRRAVAH
                     SVPGNTCTPALAEQVTAALADRLGVAPTAAALSGVGPQRLADELSALGADLSGHHESWG
                     RLARTGVAVCPVVDGEVLTETPWSALAGGRASGTELLVGHTRDEFRLFSVMSGRRGTFT
                     DEDARTALDLFAPAPDGADAYRAAYPRATAEELLETVYSDALFRMSSLQLAQANAAAGG
                     TSFLFELQLPSPAFGGALGACHSLDVPLAFGTLDSPTGRGLLGDRPAPEAVAVSREIQQ
                     AWVRFATTGDAGWAAYVPGRHLTRVLSAESTTSPYPEEASRRIWEGRAPSPFDLK"
     gene            17073..17591
                     /locus_tag="IE241_RS30600"
                     /old_locus_tag="GCM10010324_62420"
     CDS             17073..17591
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012859.5"
                     /locus_tag="IE241_RS30600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62420"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_190025110.1"
                     /transl_table=11
                     /translation="MRKSNRWVGLLGAMGLVIGGLFFTASASAQDPADPVQAQKADKSL
                     VGFLLVSYMNNRCLEVRDGNTGNGAMLDMWDCHGYPAERFYWDNGQIRSDLTGKCLDIV
                     ASNRENGAGVNMFDCHGWPAQQWHWDGNRLVSNLSGRCLDISGANPYVGASVQMWECNN
                     GPAQNWRTS"
     gene            complement(17880..18479)
                     /locus_tag="IE241_RS30605"
                     /old_locus_tag="GCM10010324_62430"
     CDS             complement(17880..18479)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241368.1"
                     /locus_tag="IE241_RS30605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62430"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190025111.1"
                     /transl_table=11
                     /translation="MSPKQQRGEATADLLLTTALRVYAESGRQGFTVNAVTAASGVSLG
                     SLYHHFGSFDGLAAALYTRCMEQLLDELVNAVKRSRTARTGVRALVLAYLRFTEEHRDA
                     ALFLHASAYSGYLVAHAEEIRAAKAAKLDGLAEWIRPRIEAGEIAPMPPALIEVLVMGP
                     VAEAARRWLASTYDDIDLAEAARILPDSIWRSLRPD"
     misc_feature    18527..18540
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.28"
                     /tool="antismash"
     misc_feature    complement(18527..18541)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.41"
                     /tool="antismash"
     misc_feature    18528..18541
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     misc_feature    18535..18546
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.59"
                     /tool="antismash"
     gene            18599..19405
                     /locus_tag="IE241_RS30610"
                     /old_locus_tag="GCM10010324_62440"
     CDS             18599..19405
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="IE241_RS30610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62440"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_190025112.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-15, bitscore:
                     51.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELLAPPTGGRPITALDDGSGPTLMVVHPGGGDATSWDGVTRHL
                     TGDFRVVRIRRRIYVPGADIALPHSMADEAADIVAIAELLKPPVLLVGHSSGAVAALEA
                     ALLAPGAFAGMFLYEPPVPTREPIAGAAGVRARAALDAGDVVEAMRIHMRDIVRMPGAT
                     VDAMFDDRHLREAVCAAAHAQIADDEAIDALGVGTDRFAALTLPTTLVQGDLSPLHLRE
                     RLADLAAVLPDARVVTLTGQGHAAHLTAPGPLAGAIRETARQVLQS"
     gene            complement(19396..21042)
                     /gene="dacB"
                     /locus_tag="IE241_RS30615"
                     /old_locus_tag="GCM10010324_62450"
     CDS             complement(19396..21042)
                     /EC_number="3.4.16.4"
                     /GO_function="GO:0004175 - endopeptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0009002 - serine-type D-Ala-D-Ala
                     carboxypeptidase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="dacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740598.1"
                     /locus_tag="IE241_RS30615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_62450"
                     /product="D-alanyl-D-alanine
                     carboxypeptidase/D-alanyl-D-alanine-endopeptidase"
                     /protein_id="WP_190025113.1"
                     /transl_table=11
                     /translation="MRGFTRGWRARAGVAAAVITAVTAASAGPAVAGRERGPGAAVEAV
                     MRKPAYAHARWGLLEVDEKGRTVRSKNAGEFFIPGSAAKLFSVSATWRTIGGGHRFTTP
                     VLAVGHRHRSALDGHLVLVGQGDLSLGGRTGPGGTMEYTDVDHTYANDVPGATLTPQNP
                     LAGIDELARQVRRSGITEVDGDVVVDSRLFTSSPNLDPAPTPLIVNDNVVDLLTTPTSA
                     GRPARLDWRPHVAPYRVDSQVRTVPAGGTTDLSVTASPDGTRITLTGTIAEGAKPVLRV
                     SPVHDPDAFGRTALIEALGRAGVTVHAPATGPNPSGLLRRARTGTERVAAYVSPPYTEY
                     AKVILKVSHNLGANLGICLMAVHTGSHRCDDGFRPLTAFLRKAGVDPRQLQLLDGRGGN
                     PVDRVTPAAFPRLLRFWERTPEAALFRRALPILGVDGSLAGSCTRAATCPAHGKVFAKP
                     GTVAGFDAVNNRLAVGGDTLAGYFDTGHGRRHTFFIGVNGASAPDIEGLLGILDDLNHI
                     AALLQQQAAMPGHWHGHRARHGGASRARLQD"
ORIGIN
        1 tcgctctgcg gcgacttggt gaagaaggcc catccctgcg ggacgaaggc cgaggagtag
       61 aacttggcgg tcggcgccca ggagggcgtc gtgacgttgt tcggcagggc gaagtagacg
      121 gaggcggcca tgacggccag cagggcggcg aacgttctga tgaaggcacc ccgttgccgg
      181 gccgcgtcgt ccgcggcccg gcagccggag tcctgtgagg agtcgtgctg gagcatggtt
      241 tacagagcgc gagccaccga ggccgccatg gcctgcttgg tgaactgcga ggtgtcgtcc
      301 gcggagcggt aggcgaccac gaagaccacg ccgacctcgg cgaccgccgc gacggtcgtg
      361 gcgacggtgc cggtctggac gacggcctgc tgggtcttga accaccagga gcccagcgcc
      421 acggcgtcgg cgcggttgcc cttgccgttg ctcaccgcct gcacgtcggc ggacagggtg
      481 gtgagggcct tctcgacctt gtaggggttg ccgctctgca cgttctgcgt gaccgcctgg
      541 tggaaggccg ggtcggtctt gcgcagcgcg gaggtcaggc tcgccacgcg ggcggcgtcc
      601 accttctgct gggggatgcc gaacttcttg aggacctcgg ggtgctcggt cgccgcgcgc
      661 ccggagccga gggtgaacag gccgacgatc tcctcgtcgg tgtacctggc cttctgcgcg
      721 gccttgaccg tgctcttctc ggcaggctcc gcggcctggg cggccggcgc gagcgtggcc
      781 attacggcgg cggcggtggc ggcgctgaca acggccgtcg tggtgcgccg gagcgccttg
      841 ctcttcatgt tgatatccac gaatcgatct tgtccggggg gcggttgccc ccacaactgc
      901 catccggcag gctgccgagt ggggggtggt ccggccgcgg gcccgtccgg cgacagcccc
      961 ctgccggggg cctggcggct gcgccgttca tcgctctgcg tacgcggggt tctgagtacg
     1021 cgtactcagg tgccctgcgg agcttttgcg cacgattgcc ccatggatca agtagtcaga
     1081 cggtgggcac cggtcggttt cctcctgggc acggcatggc tggccggggc gctggtcgtg
     1141 ccgcaggtgt ggagcgtcgg cgtggtgtgg gcgtgggcgg cgggctgggg cggcctggtg
     1201 gccgcgctcg ttgccgggag cgcggcgatg gtcgcgttgc tgttcgcggc cggcctgccc
     1261 gcccggggca tggcgcccac gccgcgtacg ctcccccggc aactggggtg ggcgatcacg
     1321 gtgttcctgg taggaagcgc cggggtcgcc ctcgggtacc tcgcccggcg atccggggac
     1381 atcggcctgg gcggcgatgc gacgctcttc ctgtggtgcg gcgtgccgta cgccgcggcc
     1441 gcggcgctgt ccgtccccgg ccgggcggta cgcgccgcag ccggaacggc gatcgcctgc
     1501 accgcagcct tcctggcatg gtcgggggac caggcgcacc ggagcgagga gctggcctcc
     1561 ctgctcaagg actcgccgct cccccgggag cgtctcctgc tgcccgaggc ccctgacggc
     1621 tacgagatcg acgaggacaa cggcagcatc tcgtcccggg ggttcagcct cggctaccgc
     1681 tacgccggac gcggcaaggt gcggcagacg atccagtacg aggtctcgcc cggcgacgtc
     1741 tccccttgcg ccgacgacag gcgccccggc cccgccacct gcaccgacct gggcggaggc
     1801 ttcaccagcg cggcccggac gctgggcgac ggcagcccct ccacggcact ggcgctgcgg
     1861 cgcgacggag tcaccctcac cgtcaccgtc tacgaacggg tggacatctc ggagctgcgc
     1921 cgcatgctgg agcgagtcca cccggccggc gacgacgagt tgctgctcgc cctgcgcttc
     1981 acgccgtaac cgcccaggcc ccacagccgc gtagccgttt ccctcatggg ggtggtttcg
     2041 gtccggtcac ggagccgctg tccgcgttct tccgattgtc tctcgaacac cgcgtacgca
     2101 gcaccgcata cgcagcagag aggcagaggg gcgccatggc agacgggact gttctgttcg
     2161 cagtacggga gcactccggg ggaggaagca ccacagccga gcaactgcgc aggatccaca
     2221 aggagttgga ggattccggt tacgaggtgc gctgggcctc cacgagcgag gacgcccggg
     2281 cggtgctgcg caccgaggcg ggactggccg ccgccgtcgt cgactgggac cttccgggaa
     2341 gcagcggcga cgacggccgg gaggacgaca aggacgacgg cgagccgggc ggcgccgacg
     2401 tcctgcgcca ggccggccgg cgcttccgga accttcccgt cttcctggtc acggccggcg
     2461 aggacctcga ccaccttccg ctgtgggtgg cggaggccgt ggtcggctac atctggccgc
     2521 tggaggacac cgcgcccttc atcgccgggc gcatcgcacg ggccgcccgc ggctaccagg
     2581 aggacctgct gccgccgttc ttcaaggcga tgcgccggtt cgacgacacg cacgagtact
     2641 cctggcacac cccggcccac gccggcggcg tcgccttcct gaagtccccg gtcggccggg
     2701 ccttctacga ccacttcggg gaacggctgc tgcgcagcga cctgtcgatc tcggtcgggg
     2761 acctcgggtc gctcttcgag cacaccggcc cggtcggcgc ggcggagcgc aacgccgccc
     2821 gtatcttcgg cgcggaccgc acctacttcg tcctgcacgg cgactcgacc tgcgaccgca
     2881 tggtcggtca cttcagcgtc acgcgcgacg agatcgcgct ggtggaccgc aactgccaca
     2941 agtcggtcct gcacgggctg gtcctgtcgg gagcgcggcc cgtctatctg gtgcccaccc
     3001 gcaacggata cgggctggcg ggcccgctgc cgcccgccga gatccaggcg cagtcggtcg
     3061 cctcccgcat cgcccgcaac ccgctgaccc ccggcgccgt ctcccccgac gcccagtacg
     3121 cagtgctcac caactccacc tacgacggcc tgtgttacga ctccctccag gtcgcccggg
     3181 ccctcgcgcc cagcacgccc cggctccact tcgacgaggc ctggttcgcc tacgcccggt
     3241 tccaccccct ctacgccggg cgctacggca tggccgtggg ccccgacacc ttccccgggc
     3301 ccgagcggcc caccgtcttc tccacccagt ccacgcacaa gcttctggca gcgctgtcgc
     3361 agtccgcgat ggtgcacgtc aagcccgcgc cccgcgcgcc ggtggagcac gagcggttca
     3421 acgaagcgtt catgatgcac ggcacgacct cgccgctgta cccgatgatc gcgtccctgg
     3481 acgtggccgc cgcgatgatg gacgggcctc agggccgctg gctgatcgac gaggcgctgg
     3541 ccgaggccgt ccgcttccgg cagacggtcg tccgcatcgg ccggcgcatc gcggccgcag
     3601 gcgaccgtcc cggctggttc ttcggcgtct ggcagcccga gacggtgacc gaccccgcca
     3661 ccggcgagca ggtgccgttc gccgacgccc ccgccgaact gctgcgcacc gacccgtcct
     3721 gctggcagct ggagcccggc gccgactggc acggcttccc cggcctgacc gagggctact
     3781 gcctgctcga ccccgtcaag gtcaccctca cgtgccccgg catcgacgcc tcggggcgga
     3841 tgtccgactg gggcatcccg gcccgcgtcc tcaccgccta cctcgccacc aggaacatcg
     3901 tggtggagaa gaccgacagc tacaccacgc tcatcctgtt ctccatgggg atcaccaagg
     3961 gcaagtgggg caccctcatg gacggcctga tggacttcaa gacgctctac gacgaggacg
     4021 cgccgctgga gcgcgtactg cccgagctgg tcgaggcgca cccgcagcgc tacaccggag
     4081 ggaccctgcg cgggctgtgc caggagatgc acgaccacct gcgcgagacg gacctggtcg
     4141 agctgctcga caccgccttc caggacctgc ccgagcccgt caccccgccc cagcactgct
     4201 accagcgcct catccgcggc ggcaccgagc gggtgcggct ggccgacgcg gcgggccggg
     4261 tggccgccgc catggtgacc gtcaccccgc ccggcatccc cgtcctcatg cccggcgaga
     4321 acaccggcac cccggacggc ccgctgctgc gctacctgaa ggccctggag tccttcgacc
     4381 ggcgcttccc cggcttccac agcgaggcgc acggagtcac cctcgacccg gacagcggcg
     4441 actacctcat cgagtgcgtc cgccgcatcc cggcgcagca ggccggggac gcggcgggcg
     4501 gggaagcggc aagcggggag ggggcagccg gggaggcggc atccgtgcgc gtcagcgacg
     4561 cgtgaacggc ctcacgtcga tcaccgtcat gcccgccgcg tgggccgcgg caatgccctc
     4621 gtcgctgtcc tcgtagacca ggcagcgcga ggcgtgcgcg ccgagcgcct cggccgcggc
     4681 gaggaagatg tccggggcgg gcttgccgcg ttcgacgtcg tcgcgcgtga cgagggcctg
     4741 gaaggcgtcg tggaacggct ggtgcttcag cgtggtctcg atgatgtgac gggccccgcc
     4801 cgaggccacc gccatcggga ggcggtgctt catcgcctcc accacggcca ggacggccgc
     4861 gtgcgggcgt acggtgtgcg cctcctccag gaacagcgcg tcccgtgcgg cgacgacctg
     4921 ctcgacgggc cgggccaggc tcagcccgcg ctcgtcgagc agggtgcgga tcatctcggc
     4981 cgaggacagg ccggtgcgcg cgtcgaacca gtcctgcgcg agctcgatgc cctcctggcg
     5041 cagggcggcg gccatggcgc ggtagttggt gtactggctg tccaccaggg tgccgtccca
     5101 gtcgaagagc aggcaggcgg cgttgcgggg tgctaggtcg ggatgcatgc gggacatcac
     5161 ctctctgttt cgagggggag agtgggaggg gtggcggcag gggcctggga aacggacgcg
     5221 gacaccggtg cggatttcgt ctcctgcatc cacctcccca gccccaccgc cgacgcggcc
     5281 gtgatcaccg cgtagacgag gaaggcgcct tccagcgaca gcccctgcac cagcggcagg
     5341 aacgtcgtgg ccacgacgaa gtccgcggcc cagtgcgccg ccgtggccag actcatgagg
     5401 gcgccccgtg cgcgggcggg gtagatctct gcgatgtaga cccagaacac cgcggcgggg
     5461 ccgacggccc cggccgtgat gaacaggcac agcaggacgg ccgtggccac gcccgggtcc
     5521 ccgaggctct ggacgcccgc gatcgccacg gctgcggcgg ccatcaccgc cagtcccccg
     5581 agcatgaggg gcctgcggcc ccaccggtcg aggaagacga tggtgaagac ggtcgccagg
     5641 acgttgcacg agcccacgag tacggacccg gcgacgcccc cgctggaggt cagaccgctg
     5701 gaggcgagga tcgtgggggc gtagtagatg gccgtgttca gcccggtgag gtggacgagg
     5761 acggcgatgg ccagacccag cgccacccag cgcggccccg cgtgtgccgc ggccgcccgc
     5821 aggctgagcc cccgggtggc ggacggcgtg ctgtcggcgg cgctcgccgg caggcccagg
     5881 cggtgcgctt cgcgggccgc gcgctccgtc cgcccgcggc tgtgcagcca ctccggggac
     5941 tcgggtacga aggggagccc ggccagcagg atcagggcgg gggcggcgcc gagggcgaac
     6001 atcgtgcgcc agttcccgga gggctccagg acgtacgcca cgacgtagga cagcagcagc
     6061 cccaccgtga tcatcagctg attgagcgtc accagcgccc cgcggcgggc cggcggcgcg
     6121 atctccgaga tgtacagggg gacggcgaac gacgtcgccc ccagtgcgag ccccaccagc
     6181 agacgtcccg cgagcagcgc cgccgtgccc tccgcggtcg cggacagcag ggtgcccgcg
     6241 gcgtagaagg cggtggcgcc gcccaggacc ggccggcggc cgaggcggtc ggccagccgg
     6301 ccgctggtgg gagcggtcag cgccgccccc agcagcgccg ccgacaccgc cgcgccctgg
     6361 gaccaggacg acaggccgta ggtgtgggag accagcggga gggctccggc gatgacaccc
     6421 gtgccatagc cgaagaggag ccctccgagc gaggtcagca gcaccgtgaa gacccggagc
     6481 ggggacggct gcacgtcccc ttgcgtcacc ggggcgtgcg tcaccggggc gccgtactct
     6541 cgtcgccgcc gcacgccact gcggtgccgc ccgcggcggc cgatgcgacg agggcctcgc
     6601 ccacgcgcgc cgtccgccgc gagtccgcga gggggacgcg gagggcggag gcgcccgtac
     6661 gtacggcctc cgcgaagtgg gccacctgca gctggtagtg gttggcggcc ggcaccgtct
     6721 cctcccggat gccgtccgcc gtgagcacgg tgatgacacc gtcctccccg ctcatggccc
     6781 aggcgttccg cacggtgatg gtcccgtggg tgccctggag ttcgtaccag gcgcggggcc
     6841 cgtagtcgat gctgtagtcg acgacggcgc tgcggccccg gccgaagtcc atcgtcgcca
     6901 ccgcgctggt gtcgacgccg aggcccggcc gccggctgaa gcgggccgag acgtcggcgg
     6961 gcgcctgccc gaagaagaac aggggcacgt cgatcgcgta gcacccgacg tcccacgtgg
     7021 cgccgccgcc gagcgccggg tcgaggcgga tgttgccgct tccggtctcg atgccgaagg
     7081 cgaacgacgc ccggacgacg cgcagttcac cgatcgcgcc ggaggcgagc agctcggcgg
     7141 cgcgcgcctg ctgcgggtgg aagcggtaca tgaacgcttc catcaccgtg cgggaggagg
     7201 cctccgcggc cgcctcgatg cgcgcgcagc ccttctcgtc catggccatg ggcttctcga
     7261 ccaggacgtg cttgcccgcc tccagggccc ggacggtcca ctcgacatgg tcggtgttgg
     7321 gcagggcgat gtagaccgcg tcgacggcgg ggtcggcgag gagggacgcg tagtcggggt
     7381 gggcggcggc gccgaacggc tcgccggccg tcgccgcctg ctccgtgcgc ccggggcggc
     7441 tggcgacggc ggtgagctcg caacccgggg tcccggcgat ggccggcatg aggtgcgtgg
     7501 cgatgtagga ggtcgcgccg agcacgcccc agcgcagggc ggcgggtgcg ggggtgggag
     7561 tgggtgcggg ggtcatgcca ggtcctcctg tacgaattcc gccgcgcgct cggcgacggc
     7621 ggccaccgcc gcgtggatgt ttccggtgat catgttcggg atgaccgagg cgtccgcgac
     7681 acgcagcccg gcaacgcccc tgacggcgag ccgcgggccg acgaccgcca tgccgtccgc
     7741 ctcctgcccg aaccggcagg tgccgaccgg gtggaactgc gtctgcgcgt tggcccggac
     7801 gaagtcctcc agctcgcggc gcgtggcggc cgggctcagc ggcccgccgg tcgcgaagtc
     7861 cgccagcggg gccgtcgccg cgatgtcgcg ggcgatgcgc acgccctcca ccagcgtgtc
     7921 gaggtcgtgc gggtcggaga ggtagcgggg gtcgatcagc gggtgggccg tagggtcggc
     7981 ggaggccagg gtgaggctgc ctcggctgcg ggggcgggtg acgcccggtc cgacggtgaa
     8041 gccgtggccg agctcggagc cgttgttcag gtccttcatg ggcgcgaagg acaactggac
     8101 gtccggggcc ggggagccgg ggtacagcgt gacgaagcct cctgcctcgc ccaggttgga
     8161 gaagtccgcg acggggtgtc cctcggtggt gtcgtaggcg agggagacct ggacgtggtc
     8221 gtggaggttg gccccgacgc cgggcaggtc cgtgacgacg ggaatgtcca gcgcggtcag
     8281 accggccgcc gggccgatgc cgctgagcag gagcagctgg gggctggcga cggcgccgcc
     8341 gcacaggatc acctcgcctg cgcagcgcac ggtggtgacg cggccctcgc gcaggatccg
     8401 tacgcccgcg gcccgcccgt tctcgacctc gacggcggtg acggtggcgc cggtcagcag
     8461 ggtgaggttc gggcggtcga gcgcggggcg gaggtgggtg tgtgcggtgt tgccgcggcg
     8521 ggcgggcgcc gcgggcgtcg tacgaccggg gccggatgcc gcgtcgtcgg tgcgtgtggt
     8581 gcggtaaagc cccacgcctt cctgcacgcc cgagttgaag tcggggttcg acggcagacc
     8641 gtacttctcc gccgctgcga cgaatgctgc cgcgaagggg tgcggagcgg tgttctccgc
     8701 gacggggatc cgcccgtact ccggcgcgcc cgccgggccc tccagggctt cgaggtacgg
     8761 catgacgtgc tgggcgtccc acatggcgcc gccccagcgg gcccacgcgt cgaagtcgga
     8821 ggccgcgccg cggacgtgca ccatggcgtt gacggcgccc gacccgccga cgacgcggcc
     8881 gcggggccag gcgaggcgcc ggccggacag tgcggcctgc ggaaccgtcc ggtacttcca
     8941 gtccagttcg ctgcccagca ggaacggcca ggacgccggg cgggcgatcc tcgggtcgtc
     9001 gtcggccggg cctgcttcca gcagcaggac ggaccggtcg cgctgctcgc tcagccgggc
     9061 cgcgacgatg cttccggctg cgcctgcgcc gacaacgatg acgtcatagg tgccgtcggc
     9121 accatggaca ccgtcggttt tcatggaacc acttccgttg gggagatcag tcgaggtgat
     9181 cagtcgaggt gatcaagggg atcgggtcag tcggaccgtg gggtggaatg cgcgagcgga
     9241 cgggcggctc agaccgccag aaagccgccg tcgacgccga tggtctggcc gttgacgtag
     9301 gacgacgccg gcgagaacag ccacatcgcc acatcggcga cctgccgcgg ggtgccgatc
     9361 tcgcccgacg ggatcaggcc ccgccaggtg gtcgccccgc ccacggccgc ctcggaggcg
     9421 gcgagcatct cggtctcgat ggggcccggt gccagtgcgt tgacccgtac gccgtcacgg
     9481 gcgtgctcca gcgccgcgac gcgcgtgagg gccacggcgg cgtgcttgga cgccacgtac
     9541 gccccgatgc cggggaacac ggtccgcaga ccgtggaccg aggtgttgtt cacgatgctt
     9601 ccgtggccct gttccgccat cagccgcagt tcctcgcgca ggcacagcca cagtccccgg
     9661 gtgttgacgg agaacgcgcg gtcgaagtcc tcctccgaca cgtcgacgag acggccgtcg
     9721 ccgggcaccc cggcgttgtt gaacgcgtag tccagacgtc cgtaggtcac ggtgatacgg
     9781 gcgaacagct cgcgtacgtc ctcgggttcg gtgacgtcgc agcggaagaa ctgcgccttc
     9841 cctcccccgg cccggatctc ttcggcggcc cggtggccac gctcttcgtt gcgggcggcg
     9901 aggaccacgg tcatgcccgc ttccgcgaac gccgcggcgg cttcccgccc gatgcctgca
     9961 ctggctcctg tgacgaggac gaccgggacc cggtcgtcgc tcatcgctgt gccccggcgg
    10021 cggagacggg agaggcggcg tcgcgggggc cgtccagcag atccgccatg gcgtcgcacg
    10081 cctgcttgat ctccacctcg gtcacgtcgt tgaggaaaca gacctcaccg atgcccgtca
    10141 gcatggggag gttctgccgg ccgtcgcggt ggcggacggt gtcctccagg gcctccagga
    10201 ccaggtccgt gtcgcagaag agggggtggg agggggccag cccgaggcgg cgcgcggcgg
    10261 cgacgatgcg ccggaggtcc tcggcccgga tcagctcgcg gttcgcggcg atcacggcgg
    10321 agaacacaca gtccatggcc acggcttcac cgtggaggag ctcggggatg gcacgcatct
    10381 ccaccagcgg agagaaggag tgcccgtagt cgaccgaccg ctcgaggttc ttctcccaga
    10441 ggttgggctc gagttccccg gccatgcccg cgatcgcgcg cccgatcacc tcgtcggcga
    10501 tctcgccggc cacgccctcc acgccgtcgt caccggcggc cggatcctgg aagcgcgagc
    10561 tgatcagcgc tgcgccgtac gtctccagga gctcgaacag gcggcggtcc ttgatgaggg
    10621 ccatcttgaa gatctcgccc atgccgttcc ggagctcccg ctccgggacc gtggcgagga
    10681 actcgcggtc gatgagcgtg cggggaggcg ggctgtagct gcccaggcgg ttgcggtaac
    10741 cgccgtagtt gataccggtc ttggccgcga cgctcacgtc gacctgggcc aggagggtgg
    10801 tggggacgcg gacgtacggt atgccgcgcc ggtacaggct cgccgccaga ccgacgacgt
    10861 cggccaccac gccgccgccg atgaccaggg gcgggctgct caggcggtgg gtgccgatct
    10921 cgttgagctt gtcggcgacc tgcatcacct gctcgatgtt cttgttctcc tccgcgcccc
    10981 ggatggtcag gtattcgacc gcggcgtcgt ggtgcgcgaa gtagttgcgg atgcgggtgc
    11041 cgtacagggc gtcgatgctg tggtcgagga ccaccaggcg ggttccggcg gcgcgaccgc
    11101 cgcccgggac tgctaagagg gcgtcgttac gggggtccag gagcccccgc gtctcgacga
    11161 tctcatagga gacggcctgt tgactccgta cctgccaggt ctgactgcgg ggagcggaaa
    11221 ccatgcagcg aatctctctt tcggagctcg gctcggtggg atatcggcgg caccggcggc
    11281 accagcggcg gacggccggc ggttgcggtc atagccgcag gcgcacgtgg gcatcggccg
    11341 ctaccgagcg gcgttcaaga tcatttcact acgaagctac taccgtcgct caaggtgaag
    11401 caagggttcc ggagcgcgaa aggttcaaga gatcaattac tcgcggaggg ggcggaggag
    11461 ggggtgggga ggacactgac gcccctcacc tgcgtgaacc tgtcaagtcg gcgaaggcgc
    11521 cgcgcgcccg ctcgggaggc gctcgggagg gttgtgttca ctatgtgaag gatggcgtcc
    11581 cgtgctgtgc gtgccgtacg gtcgcccggt gaacgtcgcg accgccgaag ggctgctcca
    11641 cctcatcgcc gccgagccca cgctgctcgc gagcgcgccc gccgacccgg acgagtcgga
    11701 cctccacctc cgtgcgcgcg acggcgggca cctgtgtctc ggctgcggtc agcccgcccg
    11761 gtgcgccgtc gtcgtcaacg cggacgtaca cgggccgcgt tggctggacc tgtgctcccc
    11821 ctgctggcag accgtgcgca cggccaacgt cctgtgcggc gaggcggaag gcggcgaggg
    11881 gcctgggaat gccggcgggc ctgagaacgc cggggggccc gagaatggag acggtcaggc
    11941 caggtcgtag acggtgaccg gcactccgcg gccggtgagc ctgcgcgtga cgagcggctc
    12001 caccatttcc caccgcccgc cggccaggcc gcagccgatc cggggcatgt gcaccgacgc
    12061 cccgagggcg agggccttgt caccgaggga ggccagggcg gcatcgatcg cttcgtaacg
    12121 caccgggacg ccgatgccgg ccgcgcgctc cgcggcggta cgtatgccgt gctgccccac
    12181 catgttggcc acccacagcc ccggctcgac ctcgacgtac tgcacggccc cgaggccgaa
    12241 gtcgttgcgc tgccggtccc tgtaccaccg gcggaaggcg gcctcggggg cgcgccaccg
    12301 ccgggagagg gccaggacga agcccctccc ccacccaccg gagtcgttgc agacgtgggc
    12361 gatgacgcgc gggccggagc cccggggggc cgtcgcgtcc ccgcgctcgt aaatgatctc
    12421 tgaaggcatg ccgcgcacct tatggccagg gactgacact ccgtccgcgg cggcgcatcg
    12481 tgccaagcgc caccggcgcc gacatcgaca ccgccaccag ccccgcgaaa accgccggcg
    12541 gccggcgcgg cgggcctgga aggatcctcc gcatgaccta cggaatcgag tcccaccccg
    12601 cctggtgagc acccaggagg agcgcagcgc gctcacccct cggacctccc tgtacgccta
    12661 cgccctgcgg ctgcacgacg cagagcccga cggctccctc cccaggggtg gctatcgcct
    12721 gccggacccg gatccggccc cggctaccac gcccccgacg gccacggccc cgccccaacg
    12781 gcccggcagc atcgaccggg ccgaagccca ggcggccgcg acggacgccg tcatcccgct
    12841 gctgaccgaa cccgacacgg tccgcgccgc cgacgaagtg caccgccgcc tccacgcact
    12901 gggcgtaggc gtcagccatg tccggcacgc cttcaccgaa ctgcccttgg aggacgaagc
    12961 ggcggcccgc gccctcggcc gccgcctggt gcgtacgggc acgagtgcac cggccgtgag
    13021 cgtcggcctc ggccttctta cccgcctcgg cgagcccgag gacgtcccct acctcaaggt
    13081 cctcggcctc ttccggacct tcacccgccc ggccatcacg gccctcacct ccatcgactg
    13141 cccggctgcg gccctggtgt ggctgagccg gtataccgag ggccgggagc tgcgccgcct
    13201 ggtcgacgcc ctgctcgccc acgacgacca ggccgcccgc gcagggctgc tgtccgtctc
    13261 cctcgacccc cgtgccgtgg ggtccgaaac cgcccgcaga atcgcggagg ccgtcatgct
    13321 cgacgacatc atcagcgacg atcccgtcga cacccgcacc ctggcccagg cgggacgcct
    13381 gctgtccagg atggcggggg cgggcacgta ccagcccgag atcctcgcct acgaccgggc
    13441 cgtcgccgcg tacgaggcct tcgtgaccgg cgcctaccga ctgcctcccg gcctcgacca
    13501 ctacgcgatc ctgctctccg tagccctcga cctgcacagc gggccgagcg ttctcctcga
    13561 ctggcggccc ggacggcgcg aagcgctcct ggacaccctg gagtccgtac tgtcggcacc
    13621 tgcgtgggcc gccgtaccca ccgaccccgg cctcaccgac cctgacctca ccgaccccgc
    13681 cgaccgccgc cgggtccgct ggatacgccg cgcggcaccg cagcccttca cccgcccgga
    13741 ggccccgggc cggctccgcg tcgaggtcgt cgtacgcgac ccggcggacc gggaacccgt
    13801 cgagacgcgg ctgctgatcg acggccgtcc cctggtcccc gaggccttcg gccggggccc
    13861 cgcccacgcc ccggagtacc tgctccacac cggccgcctg cgggccacgg ccgaacctca
    13921 ggaagtgcag ctcgccgagg cgtactgcac cgagggctgc tgcggcgcgc tctacgtcac
    13981 catccggcgc gacggggacc acgtggtgtg gagcgactgg cgccgcccgg gcaccctgcc
    14041 gtccgggcag cccgcgcccg ggctccccga gtaccgcttc gacgcgcccg cctgcgacgc
    14101 cgagatcgcg cgcgccgaga acgaccactc ctgggcctgg ccggcccgga acgccgcacg
    14161 gctgatcacc gcgggactgc gggagcggcc cggcatcctc gcccggtggg acgcccgcat
    14221 ggactgggtc ggcaccggct tccacgaccc ggacaccgtc gcggtgtcgt tcaccttcag
    14281 gccggggatc gctgccggac gccaggacaa ggacggacat tcgctgcagt tcatctggga
    14341 cttcccggac gacggcacgc caccggagga gcaggccgcc gccgcgctgc accgtctctc
    14401 gacgcaggac ccgaagggct acgcggaagt caggggcggc agccgcgagt cggccgaggc
    14461 gctgggctat ccctggccct gaccgcgtga cgccgaggcc gaggccggct gcccccgctc
    14521 tacgggatca ctgctgcccc tctccggtga acagcctgtc caggtactgg tcgacagcgg
    14581 tgagcacgtc ccgcgtgtcg atcacgtcca gctcgatgag cggcgtgaaa ccggtgaggg
    14641 cgaggagcag gttggtctcg gtcgccgggt cgcggtcggg cgggatgtgc ccgtcggcga
    14701 tcgcctggcg gatcagctgc tcgacgaggg cgcgcccttg gagcagtccg tcgcgcgccc
    14761 gcgcgtggac gtcctcgtcg tgcagtgcct ccaggacgta ggcggcgctc atccggctgg
    14821 tcgcgcgggc gtcggcgtgc agcgggaggg tttccgtgag catcagccgg agcacgtcgc
    14881 gggggtgcgg ccggtcgccg agctcctgga ggccccggcc gacgcgcagc gaggtctgct
    14941 cggccgcgaa gtccatggcg aaggagagca tcgctcctcg cgaggcgaag tagtgctgca
    15001 gcgcaccgtg agagatgccc gcctcctggg cgacctcacg catggtcaga tgcgcgacgc
    15061 cgcgctgctc caccacgcgc cacagcgctc tggcgatcgt ctcgcggcgt tcgcggtggt
    15121 ccacctgctt cggcatggct ccggcttcct cgtgacgctc tttctctttt tcttacagtt
    15181 gacataatac atctggctga taacgctggg ggtctccgga cggaagaaag gaaacgacat
    15241 gcctgcagct gaacagccgt gcgtgcgtac cacggagggg gtcgtccgag gccgcctgcg
    15301 gcaagggcac gcggtgttcc gcggcatccc ctacgcccgg ccgccggtgg gggctctccg
    15361 gttcgccgcg cccgccccgc ccgcgccctg ggaagggacc agggaggcag cggagttcgg
    15421 cccctcggta ccgcagtccg gcccggcccg cgcgattccg ccggagggcg cggagggagt
    15481 ggagggtgtg gaggatacgg atgatacgga gggcatggac tggctgacgc tcaacgtctg
    15541 taccccggat ccgggcgcgg cggggctgcc ggtgctggtg tggatccacg gaggcgccta
    15601 catcgccggt gcttcgagtg acccgatgta cgagccggcg gcgctggccg gagcaggcct
    15661 ggtcgtggtg agcatcaact accgggtggg cgccgagggt ttcgccttcc tggaaggcgc
    15721 cccggccaac cgcgggttcc tcgaccagat cgcggccttg cagtgggtgc agcggaacat
    15781 cgccgccttc ggcggggacc ccggctgcgt caccgtcgcc ggccagtccg ccggggcggg
    15841 atcggtcgcc gccttgctga cgatgaaggc ggcgcgcgga ctgttccggc gggccgtcgc
    15901 ccactcggtg ccgggcaaca cctgcacccc cgccctggcc gagcaggtca ccgccgcgct
    15961 cgcggaccgg ctcggggtgg cgcccaccgc cgcggccctg tccggcgtcg gtccgcagcg
    16021 cctggccgac gagctctcgg ccctcggcgc cgatctctcc ggacaccacg agagctgggg
    16081 gcggctcgcc cggaccggtg tcgccgtatg ccccgtcgtc gacggcgagg tcctcaccga
    16141 gactccctgg tccgccctgg ccggcgggcg cgcgagcgga accgaactcc tcgtcggcca
    16201 tacccgcgat gaattccggc tgttcagcgt catgagcgga cggcggggca ccttcaccga
    16261 cgaggacgcc cgtacggccc tggacctgtt cgccccggca ccggacggcg cggacgccta
    16321 ccgggccgcc tacccgcggg ccaccgcgga ggaactgctg gaaacggtgt actccgacgc
    16381 cctcttccgg atgtcctctc tgcagctggc ccaggcgaac gccgcagccg gcggcacctc
    16441 gttcctgttc gagctgcaac tgccctcccc cgccttcgga ggggccctgg gcgcctgcca
    16501 cagcctcgac gtccccctgg cgttcggcac gctggacagc cccaccggca gagggctcct
    16561 cggcgaccgg ccggcccccg aggccgtcgc ggtgtcgcgc gagatccagc aggcgtgggt
    16621 ccggttcgcc accaccggcg acgccggatg ggccgcctac gtacccggcc ggcacctcac
    16681 tcgcgttctg agcgccgaat cgacgacctc gccctacccg gaagaggcct cccgccgcat
    16741 ctgggagggg cgcgcgccgt cccccttcga cctcaagtag cccgccggga gccgcctacg
    16801 gcgcggcgca gctgcatcgg ccgtggcctc gaccgtcctg gcggaggtgg ccgtaggcgg
    16861 cggtcggccg ccgcctacgg cagctctcgc atgacgcggg ctttgacggc ctcatccacc
    16921 tgacggacct caccggtccg ccggcccgcc catgtcgcat acatgcatgg ccggacatgt
    16981 cctagccgcc ccacccccgc tccggcatcc tcgggcaggc aacacatcgg catgcggtgt
    17041 ccatgaccac ttcctccagc gaggagtaag ccatgcgaaa gtccaaccga tgggtggggc
    17101 tcctgggagc catggggctc gtgatcggcg gcctcttctt cacggcatca gcctcggcac
    17161 aggacccggc cgatccggtc caggcccaga aagccgacaa gtccctggtc ggcttccttc
    17221 tcgtgtcgta catgaacaac agatgccttg aagtgcgcga cggcaacacc ggcaacggag
    17281 ccatgctgga catgtgggac tgccacggtt atcccgccga gcggttctac tgggacaatg
    17341 gccagatacg cagcgacctg acgggcaagt gcctggacat cgtcgcgtca aaccgcgaga
    17401 acggcgccgg tgtgaacatg ttcgactgcc atggctggcc ggctcagcag tggcactggg
    17461 acggaaatcg cctggtgagc aacctgagtg ggcgatgcct cgacatctcc ggcgccaacc
    17521 cgtacgtcgg cgcgtccgtc cagatgtggg agtgcaataa cggccccgcc cagaactggc
    17581 gcacgtcctg agccgggcgg gacagcgccc ttcaagtcgc tgacgggttc cacccgttcg
    17641 cccgcctcac gcttgggaga gtctccgctg cggtggtgcg ggcacgtgcg gcccggtgcc
    17701 ggagccggcc ccccgaggcc acgacctgga gaaggcgggc tcgcagtgcg cggacgtgac
    17761 cgtcccgctc ggtcccggcg agcgaccgga cgtgcgtcaa gacgaccggt tgaaccgacg
    17821 gatccgatga aaccgacggg accgacggaa ccgatgcagc cgacgaacag cgcccggtct
    17881 cagtccgggc gcaaggagcg ccagatgctg tcgggcagga tgcgcgcggc ctcggccagg
    17941 tcgatgtcgt cgtaggtgct ggccagccag cggcgcgcgg cctccgcgac cgggcccatg
    18001 accaggacct cgatcagagc cgggggcatg ggggcgatct cgccggcctc gatgcgcggc
    18061 cggatccact cggcgaggcc gtccagcttg gcggccttgg cggcacggat ctcctcggcg
    18121 tgcgccacca ggtagccgga gtaggccgag gcgtggagga acagcgcggc gtcccggtgc
    18181 tcctcggtga agcgcaggta ggccagcacg agcgcgcgga cgccggtgcg tgcggtgcgg
    18241 gagcgcttca cggcgttgac gagttcgtcg agcaactgct ccatgcaccg ggtgtagagc
    18301 gcggcggcca ggccgtcgaa gctgccgaag tggtggtaga gactgcccag gctgacaccg
    18361 ctggcggccg tgacggcatt gaccgtgaac ccctgccggc ccgactccgc gtacacgcgc
    18421 agcgcggtgg tcaggagcag gtcggcggtc gcttcgccgc gttgttgctt gggggacatc
    18481 cggcgatcgt atccaccctc cggcccaaca agggtcaact agaaggaact tctagaaaaa
    18541 gtatccataa agtaccttcc tcctcaggtc agcaggccgg cacggcatcc ttgtgggcat
    18601 gacggaactt cttgcaccac ctaccggcgg ccggcccatc accgctcttg acgacggctc
    18661 cgggccgacc ctgatggtgg tccacccggg cggcggagac gcgacgagct gggacggcgt
    18721 cacccgccac ctgaccggcg acttccgcgt cgtcaggatc cggcggcgga tatacgtccc
    18781 cggcgcggac atcgcactgc cccactcgat ggcggacgag gcggcggaca tcgtggcgat
    18841 cgcggaactc ctgaagcctc ccgtgcttct cgtggggcat tcctcaggag cggtcgccgc
    18901 gctggaagcc gcgttgctcg cacccggcgc cttcgccggg atgttcctct acgaaccgcc
    18961 ggtgcccacc cgggagccga tcgccggggc ggcgggagta cgtgcccgcg ccgcgctcga
    19021 cgcgggcgac gtcgtcgagg cgatgcggat ccacatgcgc gacatcgtcc ggatgcccgg
    19081 ggccacggtc gacgcgatgt tcgacgaccg gcatctgcga gaggcggtct gcgccgcggc
    19141 gcacgcgcag atcgccgacg acgaggcgat cgacgcactc ggcgtcggca ccgaccgctt
    19201 cgcggccctc accctgccca cgaccctggt ccagggagac ctcagccccc tccatctgcg
    19261 cgagcgcctg gccgacctgg cggcggtcct gccggacgcg cgggtcgtga cgctcaccgg
    19321 acagggacac gccgcccacc tcaccgctcc gggccccttg gccggtgcga tacgggagac
    19381 ggcgcgtcag gttcttcagt cctgaagccg ggcgcggctc gcgccgccgt gccgagccct
    19441 gtgcccatgc cagtgcccgg gcatggccgc ctgttgctgc aggagggccg cgatgtggtt
    19501 gaggtcgtcg aggatgccca ggaggccctc gatgtcgggt gcggaggcgc cgttgacgcc
    19561 gatgaagaaa gtgtggcgcc ggccgtggcc ggtgtcgaag tagccggcca gggtgtcccc
    19621 gcccacggcc agccggttgt tgacggcgtc gaagcccgcg accgtgccgg gtttggcgaa
    19681 gaccttgccg tgggccgggc aggtggccgc gcgggtgcag gagccggcga gcgagccgtc
    19741 cacgcccagg atcggcaggg ccctgcggaa cagggccgcc tcgggagtgc gctcccagaa
    19801 ccgcagcagg cgggggaacg ccgccggggt gacgcggtcc acggggttgc cgccgcggcc
    19861 gtccagcagc tgcagctgac gcgggtcgac cccggccttg cggaggaagg cggtcagcgg
    19921 ccggaagccg tcgtcgcagc ggtggctgcc ggtgtgcacg gccatcaggc agatgcccag
    19981 gttggccccg aggttgtggc tgaccttgag gatgaccttg gcgtactcgg tgtagggcgg
    20041 ggacacgtac gccgcgacgc gctccgtgcc ggtccgggcg cgccgcagga ggccggacgg
    20101 gttggggccg gtcgcgggcg cgtggacggt gacgcctgcg cggccgagtg cctcgatgag
    20161 ggcggtccgc ccgaaggcgt cggggtcgtg aaccggggag accctcagta cgggcttcgc
    20221 gccctcggcg atcgttccgg tgagggtgat gcgggtgccg tcgggcgagg cggtgacgga
    20281 gaggtcggtg gtgccgcccg ccggaacggt ccgcacctgc gagtcgaccc ggtacggcgc
    20341 gacgtggggg cgccagtcga gccgggccgg gcggccggcg gacgtcgggg tggtcagcag
    20401 gtcgaccacg ttgtcgttga cgatgagcgg ggtcggggcc gggtccaggt tgggggacga
    20461 ggtgaagagc cgggagtcga cgacgacgtc cccgtcgacc tcggtgatgc cggagcgccg
    20521 cacctggcgg gccagttcgt cgatccccgc cagcgggttc tgcggggtga gcgtcgcgcc
    20581 ggggacgtcg ttggcgtagg tgtggtcgac gtcggtgtac tccatggtgc cgcccgggcc
    20641 cgtccggccg cccaggctga ggtccccctg gccgacgagc acgaggtggc cgtccagcgc
    20701 cgaccggtgc cgatgcccca cggccagcac gggtgtggtg aaccggtggc cgccgccgat
    20761 ggtccgccag gtggccgaga cgctgaacag cttggccgcg gagcctggga tgaagaactc
    20821 accggcgttc ttcgaccgga cggtgcgccc cttctcgtcg acctccagca ggccccaccg
    20881 ggcgtgcgcg tacgcgggtt tccgcatcac cgcctcgacg gcggcacccg gcccgcgctc
    20941 ccggcccgcc accgctggtc ccgcggacgc cgccgtcacc gcggtgatca cggcggccgc
    21001 gacccccgcc cgtgcccgcc atccccgcgt gaagcctctc atcgcgccac cgccacctgt
    21061 tcccggtccg ggtccggcac ggaccggtgt ccgcgccgat tgcggcagcc gtaccgcgcg
    21121 gggcgccccg ccgaacctcc cggccgccac cttcacccgc gcgccggtcc gtcacacacg
    21181 catcgccgcc ccgagcgcgg ccgacgcccg gtgggccacc tcgg
//
