LOCUS       NZ_BMUT01000017        20900 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces hiroshimensis strain JCM 4586 sequence17, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUT01000017
VERSION     NZ_BMUT01000017.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces hiroshimensis
  ORGANISM  Streptomyces hiroshimensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 160243)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 90X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650335.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:32:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,830
            CDSs (total)                      :: 6,745
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 25 of 125
            Pseudo Genes (incomplete)         :: 107 of 125
            Pseudo Genes (internal stop)      :: 4 of 125
            Pseudo Genes (multiple problems)  :: 11 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 111837
            Orig. end                         :: 132737
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUT01000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20900
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20900
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20900
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[<10000:10900](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<10001..10900)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(232..1137)
                     /gene="ligD"
                     /locus_tag="IE241_RS30005"
                     /old_locus_tag="GCM10010324_61170"
     CDS             complement(232..1137)
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954288.1"
                     /locus_tag="IE241_RS30005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61170"
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_190025000.1"
                     /transl_table=11
                     /translation="MSVSPERQAVEIGGHRLALTHLDRVLFPASGHTKAQVLQYYARIA
                     PVMVAHTADRPASFVRAPEGPGGQSWVAKNPPGGKPGWVRVVPVEHREGVTEQVVIDTT
                     AALVAMANLGAYEVHVPQWTATAGPDGHDRLVLDLDPGPGADLVVCCRVAQRLRQLLED
                     DGLTAHAVVSGSKGLHLYAPVRAASGRDAGGYAKALAARMMGEHPGLVVVSMARVERRG
                     KVLIDWSQNASAKTTAAPYTVRLREGSPGVAAPVTWDEVAACRDPDELAFTPEQVLDRA
                     ETYGDLLASLTGDATRAPLP"
     gene            1179..2213
                     /locus_tag="IE241_RS30010"
                     /old_locus_tag="GCM10010324_61180"
     CDS             1179..2213
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146160.1"
                     /locus_tag="IE241_RS30010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61180"
                     /product="Ku protein"
                     /protein_id="WP_229900033.1"
                     /transl_table=11
                     /translation="MWKGAIGFGLVSVPVRLYAATQEHGLRLHQVHDEDGGRIHLKRVC
                     EACGEQVDYEHIAKGFQDDEGHTAVVTQDELAGLPLPSKKLIDVLAFVDADRIDPLQLT
                     NGYYLAPESAAANKPYVLLRETLKQTERVAVTKIALRTRESLALLRVHGDLLTLHTMYW
                     PDEIRDSAGLAPPSSVTVRPQELKMATSLMDTLSEEFDLDELEDEYEIALSELIDAHLS
                     DRPVPRKETAPAPDNVIDLMAALQASIDNAAGKTGEKAERGAKKAAASGKSARSTAKKS
                     AAPRKRTAAKKTAAASSTSTGKRAAASSSKSATAKSTTAKSTTAKTAKAAKKTAAGKTG
                     RRAS"
     gene            complement(2232..4946)
                     /locus_tag="IE241_RS30015"
                     /old_locus_tag="GCM10010324_61200"
                     /pseudo=""
     CDS             complement(2232..4946)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018520306.1"
                     /locus_tag="IE241_RS30015"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61200"
                     /product="AAA family ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGHQREQNASAALFERELELQAAEQAVQRLCGTATEGRPRLGGL
                     LLYSGEAGLGKTALLGETRRMAIEAGKCTVLFARGSESAQPVPFHVVRQLLQPFLAPMT
                     ESDRKELLGGWYEIAGPALGIAPPIGPQDPQGVRDGIDWLVTQLATRQEPVVMMIDDAH
                     WADAESLTWLSYFAVRLQETPLLAVISYRPEELPENAPGFRALVTGRSSRPVELRALTP
                     EAVNRLVRDSFPDQADAPFCREVWAVTGGNPYETVELVAKAQDRGLKPVEESASLLRDL
                     GATSRGSGLVSRLERLGTAVTRFAWAAAVLGTEIQPSLAANLAGMGPAQAAECADKLRH
                     ARILTGAIDLEFVHPLIATAIYASIPPATRTAMHGQAAWSVTEAGLGAAAASRHLLEVH
                     PDHDSELVEQLRVAAREHLAVGAPDAARRCLERALQEPPPEEERAAVLYELGCSALLTS
                     PPTTVNHLRTALSLPHLSEDLRVDATYRLSQAYAHNNQLREAAAVVKDQAERTPPGPGR
                     MRLQAAHYLWQGIQVEEQDSLGRSRRIAELAERIRGRDNAERSLLALRAFDGMIRGEDA
                     VQVVEFAERALVDGRLAEGMGWTNTDWGFEVPSIIGITLAYTDRLDQAEELFKEAVRAF
                     EISGWSGGHLAFAHDFLGLVFRRRGELDEAEVLLREGLRLGKRLGPGLPIHWDGACLLI
                     DTLLARGRVD"
     misc_feature    complement(5100..5115)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    5101..5114
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.52"
                     /tool="antismash"
     gene            5385..6899
                     /locus_tag="IE241_RS30020"
                     /old_locus_tag="GCM10010324_61220"
     CDS             5385..6899
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467910.1"
                     /locus_tag="IE241_RS30020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61220"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_190025002.1"
                     /transl_table=11
                     /translation="MVGTGSSVQRRPVSALIWLISPLVLAVCTGTAILAVAPDARVPVA
                     WCGSSATVAVALASSEAARRGRIIAALRRRCAEQEAGLRYQLDQHETETRRLAKELLPR
                     AIHLLQRGAPTEVVLRHTLPVHDLEPGYAAAHRSVLKSVIEAVQAEEGLRDSAQRAFVN
                     IARRMQAIVHQQAYDIREMEHKHGNDPDVFGDLLHLDHGNALTGRLADSIAVLGGSRPG
                     RQWKNEIPLYNVLRGAMSRILEYRRVDLHSVADVAVVGAGVEPVIHALAELLDNATRYS
                     PPQTRVHLTAVDIQSGIAVEIEDAGVGLTDEARRRTDRVLSREGALDLDDLGEAPRLGL
                     AVVSRLARTYNFLVSLRPSAYGGVRAVLVIPMDLITASKHPGGDIARAAKLPPIKSKRR
                     PGQKIPPPAPQTAPPMMEHPIPPPLGDSGLPQRRRRRGPAPLPFGRGAAERRDRSPAPP
                     AAPAAPEEAPKQPGMWLAAFNRGINGESLEPDPGRPNSDIPSDKEE"
     gene            6925..7311
                     /locus_tag="IE241_RS30025"
                     /old_locus_tag="GCM10010324_61230"
     CDS             6925..7311
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474920.1"
                     /locus_tag="IE241_RS30025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61230"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_206329087.1"
                     /transl_table=11
                     /translation="MDWMLKDLATSVPQTRHVIVLSSDGLRMAQHGTDPDAADRLAAAC
                     AGLQSLSTAIAGEFPHGDGQMRLVVIEVDGGFFYLMAAGAGAFLAVLADDDVDAELMGM
                     RMRDLVARIGSHLTSPPRVGGSVT"
     gene            7308..7673
                     /locus_tag="IE241_RS30030"
                     /old_locus_tag="GCM10010324_61240"
     CDS             7308..7673
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712910.1"
                     /locus_tag="IE241_RS30030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61240"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_030364421.1"
                     /transl_table=11
                     /translation="MSTEGPGSPTAPGSPDRLYILTGGQARAERKTELDLVTLIVSRSE
                     ADPGLQPEHAAIVRMCAYPLSVAEISAYLELPVSTLTLLLTELVAGRHVEARPPVPAAA
                     LPDVQLLEAVMNGLQKL"
     gene            7654..8292
                     /locus_tag="IE241_RS30035"
                     /old_locus_tag="GCM10010324_61250"
     CDS             7654..8292
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004954305.1"
                     /locus_tag="IE241_RS30035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61250"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_190025003.1"
                     /transl_table=11
                     /translation="MDYRSSDPPGLETYAGPRSEDVLPASATAAVKVVIVGGFGVGKTT
                     LVGSVSEIRPLTTEETMTQAGVGVDDIAGIEHKTETTVAMDFGRISINEQLVLYLFGTP
                     GQERFWFLWNGLFEGALGAVVLLDTRRMDVSYDVIGRLEEKGVPFVVGVNRFPQAPRYP
                     MEKLRAAMDLDDSVPMVDCDARDRASCRDTLLTLMRYLYTLTTASTEHQ"
     gene            8289..9737
                     /locus_tag="IE241_RS30040"
                     /old_locus_tag="GCM10010324_61260"
     CDS             8289..9737
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326995.1"
                     /locus_tag="IE241_RS30040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61260"
                     /product="cytochrome P450"
                     /protein_id="WP_190025004.1"
                     /transl_table=11
                     /translation="MTLPSERPRTTSPAGPPPQCPAHATGPGGITRLYGPEAEADPMGL
                     YERLRQKHGQVAPVLLHDDVPAWLVLGYRENLDVARTPSRFSRDSRRWIEAREGRVAPT
                     HPLAPITTWQPICVFADGQQHERWRGAVNDSIARFDKRGIRRHVTQYSNQLVDRFCAAG
                     RADLVHEFAEQLPMMAMTQLLGMPEAYSPQLVNAARDMIKGTETAIASNEFVQETLRKL
                     VARKRVEPGADFTSWLLEHPAGLSDDEVQQHLRLVLIAAFETTANLIANTLKMVLTDHR
                     FQASLAGGHMTLPDAVEQVLWDEPPFITILGRWATQDTELAGQQIKEGDALVLGLAAAN
                     MDTVIRPDPDVPVHGNRSHLAFSGGQHECPGQDVGRAIAGEGIDALLLRLPDLTLAVEE
                     PELTYRSTLMSRHLTELPVRFTARAPLPPEETPTPAPEPPAPAQPARAEQPAIPAPPVR
                     AAAVETPGSRRSWWRSLRRLLWRR"
     gene            complement(<10001..10900)
                     /locus_tag="IE241_RS34460"
                     /pseudo=""
     CDS             complement(<10001..10900)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="IE241_RS34460"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /sec_met_domain="T1TS (E-value: 1.6e-61, bitscore: 202.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRGLSPVHPGQVPRKSGQDRCEPAWGGAVTGVRDRISVQPLENV
                     PFYCPIPPAVHPCVREIDRASVDWMLQRQLDTSAHQRQRLVRCDFGGLTARTMPYGQPG
                     ALTVVAKLHAVLFSLDDALCDESTASAHGLAHATSRIMRVLEAPVPEWPDDSPHAAALR
                     AVRLELAEHATPAQLRRWTEGMRTYLTSLVWEAACRRDRALPSVNDYAAMWMRAIGMAP
                     STALMDIAGGYELDDRDLDRPEVRALTEMTWTLVAWDNDFYSRNKEIQRAGDNLNLIDV
                     LAQERGWEPARAQEEAMAM"
     misc_feature    complement(10886..10888)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11151..12719
                     /gene="lnt"
                     /locus_tag="IE241_RS30045"
                     /old_locus_tag="GCM10010324_61280"
     CDS             11151..12719
                     /EC_number="2.3.1.269"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016410 - N-acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042158 - lipoprotein biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lnt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970540.1"
                     /locus_tag="IE241_RS30045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61280"
                     /product="apolipoprotein N-acyltransferase"
                     /protein_id="WP_190025005.1"
                     /transl_table=11
                     /translation="MTTQPPDGPYARLLTRPWPRAAAAVGAGALPALTFPTPSLWWLAY
                     VALVPWLSLIRTAPGARRAALDGWLGGGGFLLAVHHWLLPSLHVFILVLAALLGLLWAP
                     WGVLVKRLLGGSPGPARAAAALVVIPSGWLMVELARSWEYLGGPWGLFGASQWQVAPAL
                     KLASTGGIWLVSFLLVALNTAVSTVIWASRARITGLVGLVCCAAVVAGVWVWAPSPRAA
                     GTVRIALVQPGVVDGAGNVQRRFDRQEELTRKLAGQRVDLVVWGESSVGDDLVQRPDLR
                     NRLTALSRAVGADLLVNVDARRSDRPGIFKSSVLVGPGGPTGDRYDKMRLVPFGEYVPA
                     RSVLGWATSVGKAAGEDRRRGERPVVMRLPASPSAPAGLRIGPLVCFESAFPDMSRQLA
                     RDGAQVIVAQSSTSTFQHSWAPPQHASLAALRAAESWRPVVHATLTGVSTVAGPRGRAA
                     GTPLGTDRSASAVYEVPLARGTSPYVRYGDWIVLASFAVIVCTCAAEGVRLVRRRVRKP
                     AAERR"
     gene            complement(12691..13596)
                     /locus_tag="IE241_RS30050"
                     /old_locus_tag="GCM10010324_61290"
     CDS             complement(12691..13596)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884557.1"
                     /locus_tag="IE241_RS30050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61290"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_190025006.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 4.6e-18, bitscore:
                     59.2, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGCIGLGDIAQKAYLPVLATRPGLELHLHTRTPATLARVADAH
                     RIPGAQRHTDLDALLAAGLDAAFVHAATAAHPELVTRLLEAGVPVYVDKPLAYELATSE
                     RLVRLARERGVSLMVGFNRRYAPSYTQCLDHPRDLILMQKNRVGLAEDPRTLVLDDFIH
                     VVDTLRFLVPGPVEHVDVRARVRDGLMHHVVLQLSGDGFTAIGSMNRMSGSTEEILEVS
                     GQDTKRQVLNLSEVIDHKGQPSVRRRGDWVPVSRQRGIEQTVLAFLDAVQAGKLLDAED
                     ALLTHELCERIVNDALQQAS"
     gene            13703..14212
                     /locus_tag="IE241_RS30055"
                     /old_locus_tag="GCM10010324_61300"
     CDS             13703..14212
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713165.1"
                     /locus_tag="IE241_RS30055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61300"
                     /product="DinB family protein"
                     /protein_id="WP_190025007.1"
                     /transl_table=11
                     /translation="MIVPERPQPPTVSDERTSLESWLDFHRATLALKCAGLDEAQLREA
                     SAPPSSMSLMGLVRHMADVERSWFRRCLAREEAGPIYYSDEDPDRDLEVTEADGWEEAY
                     ATWQAEIAAAREAARGRSLDDRGFAPHRNKEFDLRWIYMHMIEEYARHNGHADLIRERI
                     DGATGA"
     misc_feature    14232..14248
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.77"
                     /tool="antismash"
     gene            14291..14986
                     /locus_tag="IE241_RS30060"
                     /old_locus_tag="GCM10010324_61310"
     CDS             14291..14986
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE241_RS30060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010324_61310"
                     /product="hypothetical protein"
                     /protein_id="WP_190025008.1"
                     /transl_table=11
                     /translation="MHRLPAVTVMAAVAMAAAGCVSVSQPPASHSPPRPPGHSRTGELL
                     PGPAREDLITTGPDGAPVPTAPGQDPRAATAGGASGPEGAITPSGRSGAGDHHDRADPY
                     GFGDAPELRPSDGEAEPSRSSGFPRISHPPRRAGRPWASPDRPASPDLSPSFPRSEVPS
                     SPSEQRTADSPPASASRREAPPPAQAPPPAQAPAPRARNNNVCALGRQHGRWQQGGDAS
                     RICDSVYGH"
     gene            complement(15015..15713)
                     /locus_tag="IE241_RS30065"
                     /old_locus_tag="GCM10010324_61320"
     CDS             complement(15015..15713)
                     /EC_number="3.2.2.27"
                     /GO_function="GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123495.1"
                     /locus_tag="IE241_RS30065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61320"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_190025009.1"
                     /transl_table=11
                     /translation="MTVTDVLPQSWHGVLAEELDKPYFKELTDFVEEERTKAPVYPPRG
                     EVFAALEATPYDQVKVLILGQDPYHGAGQGHGLCFSVRPGVKTPPSLRNIYKEMREELG
                     YDVPDNGYLQPWAEQGVLLLNAVLTVRGGEPNSHKGKGWEKFTDAVIRAVASRPDPAVF
                     VLWGNYAQKKLPLIDESRHVVVKGAHPSPLSAKKFFGSRPFSQINEAVAAQGHEPIDWR
                     IPDLAAVPAV"
     gene            complement(15814..16608)
                     /locus_tag="IE241_RS30070"
                     /old_locus_tag="GCM10010324_61330"
     CDS             complement(15814..16608)
                     /NRPS_PKS="Domain: PKS_KR (22-184). E-value: 5.3e-09.
                     Score: 28.2. Matches aSDomain:
                     nrpspksdomains_IE241_RS30070_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837829.1"
                     /locus_tag="IE241_RS30070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61330"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190025010.1"
                     /sec_met_domain="adh_short_C2 (E-value: 6.3e-33, bitscore:
                     107.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAQQEQEQEQRGQAGRQDTGRVALVTGASRGIGYGIAQALVARG
                     DRVVITGRNEDALKQAVESLGAGRAIGIAGKAHDEAHQAAAVQHAMEEFGRIDYLVNNA
                     GTNPVFGPMAELDLGVARKVFETNVISALGFAQQTWRAWQKDHGGAIVNIASVAGISAS
                     PFVGAYGMSKAAMVNLTLQLAHEFAPGVRVNSIAPAVVKTKFAAALYEGREEEVVASYP
                     LGRLGVPEDIGGAAAFLLSDDAGWITGQTLVVDGGIFLNAGF"
     aSDomain        complement(16057..16542)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE241_RS30070_PKS_KR.1"
                     /evalue="5.30E-09"
                     /label="IE241_RS30070_PKS_KR.1"
                     /locus_tag="IE241_RS30070"
                     /protein_end="184"
                     /protein_start="22"
                     /score="28.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGASRGIGYGIAQALVARGDRVVITGRNEDALKQAVESLGA
                     GRAIGIAGKAHDEAHQAAAVQHAMEEFGRIDYLVNNAGTNPVFGPMAELDLGVARKVFE
                     TNVISALGFAQQTWRAWQKDHGGAIVNIASVAGISASPFVGAYGMSKAAMVNLTLQLA"
     CDS_motif       complement(16447..16536)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE241_RS30070_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE241_RS30070"
                     /protein_end="54"
                     /protein_start="24"
                     /score="17.9"
                     /tool="antismash"
                     /translation="LVTGASRGIGYGIAQALVARGDRVVITGRN"
     gene            complement(16623..17384)
                     /gene="fabG"
                     /locus_tag="IE241_RS30075"
                     /old_locus_tag="GCM10010324_61340"
     CDS             complement(16623..17384)
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-170). E-value: 1.5e-21. Score:
                     69.1. Matches aSDomain:
                     nrpspksdomains_IE241_RS30075_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262869.1"
                     /locus_tag="IE241_RS30075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61340"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_190025011.1"
                     /sec_met_domain="adh_short (E-value: 2.6e-39, bitscore:
                     128.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPESEQRVAVVTGAARGIGAATALRLAREGRAVAVLDLDEEACAG
                     TVEQITAAGGRALAVGCDVSDADRVDAAVTRIAAELGAPLILVNNAGVTRDNLLFKMSE
                     SDWDTVMSVHLRGAFLMSRACQKHMVDARFGRIVNLSSSSALGNRGQANYAAAKAGVQG
                     LTKSLAKELGKFGITANSVAPGFIATEMTAATAARLGMTFEDFKAAAATQIPVERVGEP
                     EDIANAVAFFTGEEAGFVSGQVLYVAGGPLN"
     CDS_motif       complement(16788..16898)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE241_RS30075_0002"
                     /evalue="2.10E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE241_RS30075"
                     /protein_end="199"
                     /protein_start="162"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="GLTKSLAKELGKFGITANSVAPGFIATEMTAATAARL"
     aSDomain        complement(16875..17363)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE241_RS30075_PKS_KR.1"
                     /evalue="1.50E-21"
                     /label="IE241_RS30075_PKS_KR.1"
                     /locus_tag="IE241_RS30075"
                     /protein_end="170"
                     /protein_start="7"
                     /score="69.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGIGAATALRLAREGRAVAVLDLDEEACAGTVEQITA
                     AGGRALAVGCDVSDADRVDAAVTRIAAELGAPLILVNNAGVTRDNLLFKMSESDWDTVM
                     SVHLRGAFLMSRACQKHMVDARFGRIVNLSSSSALGNRGQANYAAAKAGVQGLTKSLAK
                     "
     CDS_motif       complement(17289..17357)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE241_RS30075_0001"
                     /evalue="5.70E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE241_RS30075"
                     /protein_end="32"
                     /protein_start="9"
                     /score="12.6"
                     /tool="antismash"
                     /translation="VVTGAARGIGAATALRLAREGRA"
     misc_feature    17404..17413
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(17525..17920)
                     /locus_tag="IE241_RS30080"
                     /old_locus_tag="GCM10010324_61350"
     CDS             complement(17525..17920)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181330.1"
                     /locus_tag="IE241_RS30080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61350"
                     /product="DUF3037 domain-containing protein"
                     /protein_id="WP_058041356.1"
                     /transl_table=11
                     /translation="MTGRHNGREVFEYALLRVVPRVERGEQINAGVVVYCQAKGYVAAR
                     VHLDEARLLALDPTADVAGVRAALCAVEGVCLGGERAGQAAGDDPGRRFRWLIAPRSTV
                     VQPGPVHAGLTADPESEPERLLDLLVR"
     gene            complement(17917..18741)
                     /locus_tag="IE241_RS30085"
                     /old_locus_tag="GCM10010324_61360"
     CDS             complement(17917..18741)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181329.1"
                     /locus_tag="IE241_RS30085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61360"
                     /product="HipA family kinase"
                     /protein_id="WP_190025012.1"
                     /transl_table=11
                     /translation="MLPEVTATRYVTPLREGGSLPGIVEADDLGTYVMKFTGAGQGRKT
                     LVAEVVCGQLGRALGLRVPDLARIQLDPVIGRGEPDQEVQGLLKASGGLNLAMDFLPGA
                     LGFDPLAFEVGAAEAGRVIWFDALINNVDRSWRNPNLLVWHGELWLIDHGATMIWHHNW
                     PGAAAAAGKAYDASDHVLATFGPDLAAAAAELAPRVTEELLTEVAADVPDEWLADEPGF
                     DGPDAVRRAYVEVLLERAKGIGDRITVGERSKDKPSQAPEWVRVRLDGRAGT"
     gene            18837..19361
                     /locus_tag="IE241_RS30090"
                     /old_locus_tag="GCM10010324_61370"
     CDS             18837..19361
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018532537.1"
                     /locus_tag="IE241_RS30090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61370"
                     /product="Rieske (2Fe-2S) protein"
                     /protein_id="WP_190025013.1"
                     /transl_table=11
                     /translation="MNHTSRTASPASAGSTAPTGSTDSTSPAASRAPRGSTRRSVVAAA
                     GAAGLVTVLAACGGGGGDNEDKGQAEDKGQGKDKEGELGKVSDIPEGGGKVFADRKVVV
                     TQPAKGEFKAFSAVCTHQGCLVKEVSGGTINCPCHGSRFAVADGSVKGGPAPRPLPEEQ
                     VSVHDGSLHLG"
     gene            complement(19384..20028)
                     /locus_tag="IE241_RS30095"
                     /old_locus_tag="GCM10010324_61380"
     CDS             complement(19384..20028)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959655.1"
                     /locus_tag="IE241_RS30095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61380"
                     /product="cysteine hydrolase"
                     /protein_id="WP_190025014.1"
                     /transl_table=11
                     /translation="MAPPDPPAERLDPATTVLLTVECQSGVVGPDSALPELAAAARASG
                     ALVNIARLVAGAHDAGVQVVHAIAERRPDGRGASRNARLFRAAERLPVQQLTGTRAVRV
                     ADPIPVGDADLVVRRLHGLSPLAGTGVDALLRNLGCRTLVVTGVSANVAVPNTVFDAVN
                     LGYTAVVPADAIAGVPADYTAAMVSHTLALVATVTTAEAVLRGWRSTPRSG"
     gene            20223..20735
                     /locus_tag="IE241_RS30100"
                     /old_locus_tag="GCM10010324_61390"
     CDS             20223..20735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957177.1"
                     /locus_tag="IE241_RS30100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_61390"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_190025043.1"
                     /transl_table=11
                     /translation="MGTGATQRRGRRIMMTRPELDSFLAGQRTCRVATVGRDGHPHLSA
                     LWFAWDGSAVWLYSIVCSRRWAQLRRDARIAVLVDDGREYGELRGAELSGTAAFVGEAP
                     RTGDPCPELAAPEALFTAKYFGGLPSMPYDGRHAWLRLLPEAVVSWDFRKLPGAPGTPG
                     TAGTPGG"
ORIGIN
        1 cgcgcgcgga cccgccgttc gccggtcccg tcgacgtgcc gggtgcgcag tgggtcgagc
       61 cccggctcgt cgccgaggtc gtcttctccg gctggacggc gtccggccgc ctccggcacc
      121 ctgtctggca ccggctgcgc cccgatctga cgcggctcgg ctgacgcagc ccggcgacac
      181 ggcttcgctg acgccgcccg accggctcgg ctcggccggc gccggggggc gtcacgggag
      241 gggcgcgcgg gtggcgtcgc cggtgagcga ggccagcagg tccccgtacg tctccgcccg
      301 gtccagcacc tgctcggggg tgaacgcgag ctcgtccggg tcccggcagg cggcgacctc
      361 gtcccaggtg accggggcgg ccaccccggg gctgccctcc cgcagccgca cggtataggg
      421 cgcggcggtg gtcttggcgc tcgcgttctg cgaccagtcg atgaggacct tcccccggcg
      481 ttcgacgcgc gccatggaga ccacgacgag gccggggtgc tcgcccatca tgcgggcggc
      541 cagcgccttg gcgtagccgc cggcgtcccg gccggacgcg gcgcggaccg gcgcgtacag
      601 gtgcaggccc ttggagccgg agacgacggc gtgggcggtg agcccgtcgt cctccaggag
      661 ctgacgcagc cgctgggcga cccggcagca gaccacgagg tcggcgcccg ggccggggtc
      721 caggtccagg acgagccggt cgtggccgtc ggggccggcg gtcgccgtcc actgcgggac
      781 gtgcacctcg tacgcgccga ggttggccat cgcgaccagg gcggccgtgg tgtcgatgac
      841 gacctgctcg gtgacgccct cgcggtgctc caccggaacg acccgcaccc acccgggctt
      901 gccgccgggc gggttcttgg cgacccagct ctgcccgccc ggaccctccg gggcgcggac
      961 gaaggaggcg ggccggtcgg ccgtgtgcgc caccatcacc ggggcgatgc gtgcgtagta
     1021 ctgcagcacc tgcgccttgg tgtggcccga tgccgggaag agcacccggt cgaggtgggt
     1081 cagggccagc cggtggcccc cgatctccac cgcctgccgc tccggggaga cggacataag
     1141 gtaggaattc cccgtggagg gataaaacta tgcggaccat gtggaaaggt gcgattggct
     1201 tcgggctggt gtccgtgccc gtccggctgt acgccgccac ccaggaacac ggcctcagac
     1261 tgcaccaggt ccacgacgag gacggcggcc ggatccacct caagcgcgtc tgcgaggcct
     1321 gcggcgaaca ggtcgactac gagcacatcg ccaagggctt ccaggacgac gagggacaca
     1381 ccgccgtcgt cacccaggac gagctggccg ggctgccgct gcccagcaag aagctcatcg
     1441 acgtgctcgc cttcgtcgac gccgaccgga tcgaccccct gcagctcacc aacggctact
     1501 acctggcgcc cgagagcgcg gcggcgaaca agccctacgt cctgctgcgc gagaccctca
     1561 agcagaccga acgggtggcc gtcaccaaga tcgcgctgcg cacccgggag tccctggccc
     1621 tcctgcgggt ccacggcgac ctgctcaccc tgcacaccat gtactggccg gacgagatcc
     1681 gcgacagcgc cggcctcgcc ccgccctcct cggtcaccgt gcggcctcag gagctgaaga
     1741 tggcgacgag cctgatggac accctctccg aggagttcga cctcgacgag ctggaggacg
     1801 agtacgagat cgccctgagc gagctgatcg acgcccacct gtccgaccgg ccggtcccca
     1861 ggaaggagac ggcacccgca ccggacaacg tcatcgatct gatggccgcc ctccaggcgt
     1921 ccatcgacaa tgcggccggg aagacggggg agaaagcgga gagaggcgcc aagaaggcgg
     1981 ccgcatccgg gaaatcggcg cggagcaccg caaagaaatc cgccgcaccg cgaaaacgca
     2041 cggccgccaa gaagacggcg gcagcctcct ccacctccac gggcaagagg gccgccgctt
     2101 cctcctccaa gagcgcaacg gccaagagca ccaccgccaa gagcaccacg gccaagacgg
     2161 ccaaggcggc caagaagacg gcggccggga agaccggccg ccgcgcttcc tgaacccggc
     2221 ccgcccgggg ctcagtgcac ggtgtcgccc gccggctcgg ctccttcgca caccgccgac
     2281 gcaagatcgg cccgtgccgt ctccacgagc ccgtccgccg cgcactgctg ggacacttcc
     2341 agtccctcgc gcagccgctc ggccgcctcg gacagccggt cggccctcag cagcgccgaa
     2401 ccgtgggcga cgagggccgc cgcgaactcg tacttgcacg gggagcggcg caggtgcacg
     2461 acggcctgac cgagcttcac cagggcctcg tccggcccgg cgaccagggc cgcccggcgc
     2521 agggcctcgc cgacggcggt gtccgtaccg aagcgggcgg catgacggac ggccttgtcg
     2581 gccagggtgc gggcgcgctc ggggtcctcg tccttgaggg cgacggccag gtcgagcgcc
     2641 cagggagccc agagggtgtt gttccggccg cgctcctcca gcctgcgccc ggcggtctcc
     2701 agctccttga tcgcctcttt tctgcggccc tgggcaagca gcaggcgccc ggccaggcac
     2761 gcggcctccg gcagcacgat cgccggtgtg tagggcggct ggaagccgtt ctcctcggcg
     2821 aaggcctggg cctagtcgac ccggccgcgc gcgagcaggg tgtcgatcag caggcaggcg
     2881 ccgtcccagt ggatcggcag gccggggccg aggcgcttgc ccagccgcag gccctcgcgc
     2941 agcagcacct cggcctcgtc cagctctccg cggcggcgga agaccaggcc gaggaagtcg
     3001 tgcgcgaagg cgaggtggcc gccgctccag ccggagatct cgaaggcccg tacggcctcc
     3061 ttgaagagct cttcggcctg gtcgagccgg tcggtgtagg ccagggtgat gccgatgatg
     3121 ctggggacct cgaagcccca gtcggtgttg gtccagccca tgccctcggc gagccggccg
     3181 tccaccaggg cccgctcggc gaactcgacc acctgcacgg cgtcctcgcc gcggatcatg
     3241 ccgtcgaagg cgcgcagcgc cagcaggctc cgctcggcgt tgtcgcggcc gcggatgcgt
     3301 tcggcgagct cggcgatgcg gcgcgagcgg cccagggagt cctgctcctc cacctggatg
     3361 ccctgccaca gatagtgcgc ggcctgcagg cgcatccgcc cggggcccgg cggggtgcgc
     3421 tcggcctggt ccttgacgac cgcggccgcc tcgcggagct ggttgttgtg cgcgtaggcc
     3481 tgggagaggc ggtaggtggc gtcgacgcgc aggtcctcgc tgaggtgcgg cagggagagc
     3541 gccgtcctga ggtggttgac ggtggtcggc ggcgaggtga gcagcgcgga acagccgagc
     3601 tcgtagagga cggcggcccg ctcctcctcg ggcggcggct cctgcagggc gcgctccaga
     3661 cagcggcggg ccgcatccgg cgcgccgacc gccaggtgct cgcgggcggc cacgcgcagc
     3721 tgctcgacca gctcggagtc gtggtcgggg tggacctcca gcaggtgccg ggaggccgcg
     3781 gcggcgccga gccccgcttc ggtgacggac caggccgcct gcccgtgcat ggcggtgcgg
     3841 gtggcgggcg ggatcgaggc gtagatggcg gtggcgatca gcgggtggac gaattccagg
     3901 tcgatggcgc cggtgaggat acgggcgtgc cgcagcttgt ccgcgcactc ggcggcctgg
     3961 gcaggcccca tgcccgcgag gttcgccgcc agggacggct ggatctcggt gccgaggacg
     4021 gccgccgccc aggcgaagcg ggtgacggcg gtgcccagcc gctccaggcg ggacaccagc
     4081 ccgctgccgc gggaggtggc gccgaggtcg cgcaggaggg aggcggactc ctcgaccggc
     4141 ttgaggccgc ggtcctgtgc cttggcgacc aactcgacgg tctcgtaggg attgccgccg
     4201 gtgacggccc agacctcgcg gcagaacggg gcgtcggcct ggtccgggaa ggagtcgcgc
     4261 accaggcggt tgaccgcttc cggcgtcagg gcgcgcagct ccacggggcg ggagctgcga
     4321 ccggtgacca gagcgcggaa gcccggtgcg ttctccggga gttcctccgg gcggtaggag
     4381 atgacggcga gcagcggcgt ctcctgcagg cgcacggcga agtaggagag ccaggtgagc
     4441 gattcggcgt cggcccagtg ggcgtcgtcg atcatcatca ccaccggctc ctgccgtgtg
     4501 gcgagttggg tgacgagcca gtcgatgccg tcgcgcacgc cctgggggtc ctgcggaccg
     4561 atcggcgggg cgatgcccag cgcggggccg gcgatctcgt accagccgcc gagcagctcc
     4621 ttgcggtcgc tttcggtcat cggcgccagg aacggctgga gcagctggcg gacgacgtgg
     4681 aaggggaccg gctgcgcgga ctcgctgccg cgcgcgaaga ggacggtgca cttgcccgcc
     4741 tcgatggcca tccggcgcgt ctcgccgagc aacgccgttt tccccaggcc cgcttcgccg
     4801 ctgtagagca gcaggccacc cagccggggc cgcccttcgg tcgcagttcc gcacagcctt
     4861 tgcaccgctt gttcagcggc ttgcagctcg agctcccgct cgaacagggc ggcggatgcg
     4921 ttctgttcac gctgatgccc tgacatggcg atgtctcccc ggaagatgtg gtggggcgag
     4981 cctagccccg tccgtgaggc caggggcagg gttcggcaga cggaccactc gggagcgtga
     5041 ccctcccccg cccgcccccg gagcccgttc cgcaccacgg gcagcatgcc caacttgcac
     5101 cgaacacaca ttcatacgat tcgtaaaccc attcggaatt cgaagcgcga ggccattatg
     5161 gagcctttcg aattcctacg tcaggccaat ctgcgaatat gacaacttcg cgcatgagcc
     5221 ccgcgcgacc ggctacgctc catgtcgcgc agcgggttgt ggcgactact tcacggtgcg
     5281 cacaagtgct gcgccggcgc cgttctccgc gggagacacc cggagaatgc cgcgcgccgg
     5341 atcccgttgc agatacgcct ccttacagag ttccgaggat cccgatggtt ggtaccggct
     5401 cgtcagttca acggcggccc gtctccgctc tgatatggct gatctccccc ttggtgctgg
     5461 ccgtgtgcac gggtacggcg attctcgccg tcgctcccga cgcccgcgtg ccggtggcct
     5521 ggtgcgggtc ctcggccacg gtcgcggtgg cgttggcaag ctccgaggcc gcccggcggg
     5581 gacggatcat cgccgccttg cggcggcgct gcgccgagca ggaggccggc ctgcggtacc
     5641 agctcgacca gcacgagacg gagacccgcc ggctggccaa ggagctgctg ccccgggcca
     5701 tccacctgct gcagcgcggc gcccccaccg aggtcgtgct gcgccacacg ctgcccgtcc
     5761 acgacctcga acccggctac gcggccgccc accgctcggt gctgaagtcc gtcatcgagg
     5821 ccgtgcaggc ggaggagggg ctgcgtgact ccgcgcagcg cgccttcgtc aacatcgccc
     5881 gccgcatgca ggccatcgtg caccagcagg cctacgacat ccgggagatg gagcacaagc
     5941 acggcaacga cccggacgtc ttcggcgacc tcctccacct cgaccacggc aacgccctga
     6001 ccggccgcct cgccgacagc atcgccgtcc tcggcggctc ccgccccggc cgccagtgga
     6061 agaacgagat cccgctgtac aacgtgctcc gcggcgccat gtcgcggatc ctggagtacc
     6121 ggcgggtcga cctgcactcg gtggccgacg tcgccgtcgt cggggccggc gtcgagccgg
     6181 tgatccacgc cctggccgag ctgctggaca acgccacccg ctactcgccc ccgcagaccc
     6241 gggtgcacct gacggccgtg gacatccagt ccggcatcgc cgtcgagatc gaggacgccg
     6301 gggtcggcct gaccgacgag gcgcgccgcc gcaccgaccg cgtcctctcc cgcgagggcg
     6361 ccctcgacct cgacgacctc ggcgaggcgc cgcggctcgg cctcgcggtc gtcagccggc
     6421 tcgcccgcac gtacaacttc ctggtgtcgc tgcggccctc cgcctacgga ggcgtccggg
     6481 ccgtgctggt catccccatg gacctgatca ccgccagcaa gcaccccggc ggcgacatcg
     6541 cccgcgccgc caagctcccg cccatcaagt ccaagcgccg cccgggccag aagatccccc
     6601 cgcccgctcc gcagacggct ccgccgatga tggagcaccc catcccgcca ccgctcgggg
     6661 acagcgggct gccgcagcgg cggcggcggc gcggccccgc gccgctcccg ttcggccggg
     6721 gcgcggccga acggcgggac cggtcaccgg ccccgcccgc cgcgccggcc gctccggagg
     6781 aggcccccaa gcagcccggg atgtggctgg ccgccttcaa ccgcggcatc aacggggagt
     6841 ccctggagcc ggatcccggc cggccgaaca gtgatatccc gtcagacaag gaagagtagc
     6901 caagtgacgc agccgcggtt caacatggac tggatgctca aggacctggc aaccagtgtt
     6961 ccgcagaccc gccacgtgat cgtgctgtcc tcggacggcc tgcgcatggc tcagcacggc
     7021 accgacccgg acgccgccga ccgcctggcc gccgcctgtg ccggactgca gagcctctcg
     7081 acggcgatcg ccggtgagtt cccgcacggg gacgggcaga tgcgcctggt cgtgatcgag
     7141 gtcgacggcg gattcttcta tctgatggcc gccggggccg gggccttcct ggcggtgctg
     7201 gccgacgacg acgtggacgc cgagctgatg ggcatgcgga tgcgggatct ggtggcccgc
     7261 atcggttcgc atctcaccag tccgccgcgg gtcggcgggt cggtgacatg agcacggagg
     7321 gacccggctc cccgacggcg cccggcagcc ccgaccggct gtacatcctc accggaggcc
     7381 aggcccgcgc ggagcgcaag acggagctcg acctggtgac gctgatcgtc tcccggtccg
     7441 aggccgaccc cgggctgcag cccgagcacg ccgccatcgt caggatgtgt gcctacccgc
     7501 tctccgtcgc cgagatatcg gcctatctgg agctgccggt cagcaccctg accctgctgc
     7561 tcacggagct ggtggcgggc cggcacgtgg aggcccggcc gccggtcccg gcggcagccc
     7621 tgcccgacgt acaacttctg gaggcggtga tgaatggact acagaagctc tgatcccccg
     7681 gggttggaga cctatgcggg gccgcgcagc gaggacgtcc tgccggcctc ggccaccgcg
     7741 gccgtcaagg tggtcatcgt cggcggattc ggggtcggca agacgaccct ggtgggctcg
     7801 gtgagcgaga tccggccgct gaccaccgag gagacgatga cccaggccgg tgtcggcgtg
     7861 gacgacatcg ccggcatcga gcacaagacc gagacgaccg tggccatgga cttcggccgg
     7921 atcagcatca acgagcagct ggtgctgtat ctgttcggca cgcccggcca ggagcgcttc
     7981 tggttcctgt ggaacggcct gttcgagggc gccctcggtg cggtcgtcct cctcgacacc
     8041 cgccgcatgg acgtcagtta cgacgtgatc gggcgccttg aggagaaggg ggtgccgttc
     8101 gtcgtcggcg tcaaccgctt cccccaggcc cccagatatc cgatggagaa actccgggcg
     8161 gccatggacc tcgacgactc ggtgcccatg gtcgactgcg acgcccggga ccgcgcctcc
     8221 tgccgcgaca ccctgctcac cctcatgcgc tacctctaca cgctcaccac cgcctccacg
     8281 gagcaccagt gaccctgcct tccgaacgcc cccgcaccac ctccccggcc gggcctcccc
     8341 cgcagtgccc ggcacacgcg accggccccg gcggcatcac ccggctctac ggccccgagg
     8401 ccgaggccga ccccatgggg ctgtacgagc ggctccgcca gaagcacggc caggtggcgc
     8461 ccgtcctgct gcacgacgac gtcccggcct ggctcgtcct cggctaccgc gagaacctcg
     8521 acgtggcgcg taccccctcg cgcttctcgc gcgactcccg gcggtggatc gaggcgcggg
     8581 agggccgcgt ggcgccgacc cacccgctcg cgccgatcac cacctggcag ccgatctgcg
     8641 tcttcgccga cggccagcag cacgagcgct ggcgcggtgc cgtcaacgac agcatcgccc
     8701 gcttcgacaa gcggggcatc cgccgccacg tcacccagta ctcgaaccag ctcgtcgacc
     8761 gcttctgcgc cgcgggccgg gccgatctgg tgcacgagtt cgcggagcag ctgccgatga
     8821 tggcgatgac gcagctgctg ggcatgccgg aggcgtacag cccccagctc gtcaatgccg
     8881 cccgggacat gatcaagggc accgagacgg cgatcgcgag caacgagttc gtccaggaga
     8941 cgctgcgcaa gctggtggcg cgcaagcgcg tcgagccggg cgccgacttc accagctggc
     9001 tgctggagca ccctgccggg ctgtcggacg acgaggtgca gcagcatctg cggttggtgc
     9061 tgatcgcggc cttcgagacc acggcgaacc tcatcgcgaa caccctgaag atggtgctca
     9121 ccgaccaccg cttccaggcc tcgctggccg gcgggcacat gacgctgccg gatgcggtcg
     9181 agcaggtcct gtgggacgag ccgccgttca tcacgatcct gggccgctgg gcgacgcagg
     9241 acacggagct ggccggtcag cagatcaagg agggggacgc cctggtcctg gggctggccg
     9301 ccgccaatat ggacacggtg atccgccccg atcccgacgt ccccgtccac ggcaaccgct
     9361 cgcacctggc gttcagcggc ggtcagcacg agtgcccggg ccaggacgtc ggccgggcga
     9421 tcgcgggcga gggtatcgac gccctgctgc tgcggctgcc cgacctcacc ctcgcggtgg
     9481 aggagccgga gctgacctac cgctcgaccc tgatgtcccg tcacctgacc gagctgccgg
     9541 tccggttcac ggcgcgggcg ccgctgcctc cggaggagac gccgacaccc gcgccggagc
     9601 cgccggcgcc cgctcagccg gcccgcgccg agcagccggc catcccggcg ccgccggtcc
     9661 gggccgccgc cgtggagacg cccggttcgc ggcggtcgtg gtggaggtcg ctgcggcgcc
     9721 tgctgtggcg gcggtagcag ccggcctcga gctggtccca ccaccaggcg atggagggaa
     9781 tgggcaaggg cgccgggctg tcgtccgacg ggagtggctt ccaccactcc gcgccctccc
     9841 cggccccgta ggggtccagg tagcgggcgc agcccgaggc ccagtccagg tgcccgcgga
     9901 cgaagtgtcc cagcgccacc agatagcagc gcagttccac tccggccatg ggccagatct
     9961 gctcccgtaa gcgcaggaag agcgtcatga cgcggtcgcg catcgccatg gcctcttcct
    10021 gggcgcgggc gggttcccag ccgcgctcct gggcgaggac gtcgatcagg ttgaggttgt
    10081 cacctgcacg ctggatctcc ttgttccgtg agtagaagtc gttgtcccag gcgacgagcg
    10141 tccaggtcat ctcggtgagg gcccggacct cgggccggtc caggtcgcgg tcgtcgagct
    10201 cgtagcctcc tgcgatgtcc atcagggcgg tggagggtgc catgccgatg gcacgcatcc
    10261 acatggcggc gtagtcgttc accgacggca gggcgcggtc gcggcggcag gcggcctccc
    10321 acaccaggct ggtcaggtag gtgcgcatgc cttcggtcca gcggcgtagc tgggccggtg
    10381 tcgcgtgctc ggccagctcc aggcggacgg cccgcagcgc cgcggcgtgg ggcgagtcat
    10441 ccggccactc cggcaccggc gcttccagga cgcgcatgat gcgtgaggtc gcgtgcgcca
    10501 ggccgtgggc gctggcggtc gactcgtcgc acagggcgtc gtccagggag aagagcacgg
    10561 cgtggagctt ggcgacgacg gtgagcgctc cgggctgacc gtagggcatg gtccgggccg
    10621 tgagcccgcc gaagtcgcac cggacgaggc gctgtcgctg gtgggccgag gtgtcgagct
    10681 gccgctggag catccagtcg accgacgcgc ggtcgatctc ccggacgcac gggtgcaccg
    10741 ccggcggtat cgggcagtag aagggcacgt tctccaaggg ctgtactgat atgcgatctc
    10801 gcacgcccgt cacggcgcct ccccaggccg gctcgcagcg atcctgtcca cttttgcgcg
    10861 gtacctgccc agggtggacc ggggataacc cgcggcgcat acccggtcac acctttccag
    10921 cgcgggacgg aaggctcact tcggatcgtt tctgaccgga cccggccaaa agagcttttc
    10981 ccatgagagg cgacggtgga atattgcacc ccgatgtcgg agttttttcc ccatgatcct
    11041 ccgctgttcg aaaacataag ggtttggccg gatctcgctc acgcgtcacg cggacgaatg
    11101 atcgacgatc tacgacggcc ggcgaccgtt cgggcccagg gaggcacgcc atgacgacgc
    11161 aaccgccgga cggcccgtac gcccggctgc tgacccggcc ctggccacgg gcggctgcgg
    11221 cagtgggggc gggagcgctg cccgccctca cgtttcccac gccttcgctg tggtggctgg
    11281 cctacgtggc tctcgtgccc tggctgtccc tgatccgtac ggcgccgggc gcgcggcggg
    11341 cggcgctcga cggctggctc ggcggtggcg gattcctgct cgccgtgcac cactggctgc
    11401 tgccgagcct gcacgtcttc atcctggtgc tggccgcgct gctggggctg ttgtgggcgc
    11461 cgtggggcgt gctggtcaag cggctgctgg gcggttcccc ggggcccgcg cgggccgccg
    11521 cggccctcgt ggtcatccct tccggctggt tgatggtcga acttgcccgt tcatgggagt
    11581 atttgggcgg accgtggggt ctgttcgggg cgagccagtg gcaggtggca ccggccctga
    11641 agctcgcttc aacgggtggg atctggctgg ttagtttcct cctcgtggcc ctcaacaccg
    11701 ccgtttccac ggtcatttgg gcttctcgcg cgcgtatcac cggactagtc ggtctggtct
    11761 gctgcgcagc ggtcgtcgcc ggggtgtggg tgtgggcgcc ttcgccgcgc gctgcgggca
    11821 ccgtccggat cgcgctcgtg cagccgggcg tcgtcgacgg ggcgggcaac gtccaacggc
    11881 ggttcgaccg ccaggaggag ctcaccagga agctggccgg gcagcgggtg gacctcgtcg
    11941 tatggggcga gagcagcgtg ggcgacgatc tcgtgcagcg ccccgacctg cggaaccggc
    12001 ttacggcgct ctcccgcgcg gtgggcgcgg acctcctcgt caacgtcgac gcgcgccgct
    12061 cggaccggcc cggcatcttc aagagttccg tgctcgtcgg ccccggcggc ccgaccggcg
    12121 accgctacga caagatgcgg ctcgtgccgt tcggggagta cgtgccggcg cggtcggttc
    12181 tcggctgggc gacgtcggtg ggcaaggcgg ccggcgagga ccgcaggcgc ggcgaacgcc
    12241 ccgtggtgat gcggctgccc gcttccccct ccgccccggc gggcctgcgg atcggtccgc
    12301 tggtgtgctt cgagtcggcc tttcccgaca tgagccggca gctggcgcgc gacggcgccc
    12361 aggtgatcgt ggcgcagtcc tccacctcga cgttccagca cagctgggcc ccgccgcagc
    12421 acgcctcgct cgccgcgctg cgggccgccg agagctggcg gccggtggtg cacgcgacgc
    12481 tgacgggggt gagcacggtc gccggtccgc ggggccgggc ggccggaacc ccgctcggca
    12541 ccgaccgcag cgcctccgcc gtgtacgagg tgccgctggc ccgcggcacg agcccctacg
    12601 tccggtacgg ggactggatc gtcctggcgt cctttgcagt gatcgtctgc acgtgcgccg
    12661 ccgagggcgt ccgtctggtg cgacgtcgtg tcaggaagcc tgctgcagag cgtcgttgac
    12721 gatgcgctcg cacagctcgt gggtgagcag cgcgtcctcg gcgtcgagca gcttgcccgc
    12781 ctgcaccgcg tcgaggaagg cgaggacggt ctgctcgatg ccgcgctgcc gggagacggg
    12841 cacccagtcg ccgcgcctgc ggacgctggg ctgtcccttg tggtcgatca cctcggagag
    12901 gttgaggacc tgccgcttgg tgtcctgccc ggagacctcc aggatctcct cggtggagcc
    12961 gctcatccgg ttcatggagc cgatggccgt gaagccgtcg ccggagagct ggagcacgac
    13021 gtggtgcatg aggccgtcgc ggacgcgggc gcgcacgtcc acgtgctcga cgggcccggg
    13081 gacgaggaag cgcagggtgt cgacgacgtg aatgaagtcg tcgagcacga gggtgcgcgg
    13141 gtcctcggcc agcccgacgc ggttcttctg catcaggatc aggtcgcgcg ggtggtccag
    13201 gcactgggtg taggacggcg cgtagcggcg gttgaagccg accatcaggc tgacgccccg
    13261 ctcccgggcg aggcgcacga gccgctcgct ggtggcgagc tcgtaggcga ggggcttgtc
    13321 gacgtagacc ggaacgccgg cttcgaggag gcgggtgacg agctcggggt gggccgcggt
    13381 cgcggcgtgg acgaaggcgg cgtcgaggcc cgccgcgagc agcgcgtcga ggtcggtgtg
    13441 gcgctgggcc ccggggatgc ggtgggcgtc ggcgacgcgc gcgagcgtgg cgggggtgcg
    13501 ggtgtggagg tggagttcga ggccgggccg ggtggcgagc accggaaggt aggccttctg
    13561 tgcgatgtct ccgagcccga tgcagccgac cttcacagtg cctccctggt acgtgccttc
    13621 gtttgggaag catacgggcg tacggaaggg cgccggcgaa aacctctggc gcgggcggca
    13681 cggggacgcc aggatgaccg ccatgatcgt tcctgagcgt ccccagcccc ccaccgtctc
    13741 cgacgagcgc accagcctgg agagctggct cgacttccac cgcgccacgc tggccctcaa
    13801 gtgcgcgggc ctggacgagg cgcagctgcg cgaggcctcc gcgccgccgt cctcgatgag
    13861 cctcatgggt ctcgtccggc acatggccga cgtcgagcgc agctggttcc gccggtgtct
    13921 ggcccgcgag gaggccgggc cgatctacta ctccgacgag gatccggacc gggacctgga
    13981 ggtcacggag gcggacggct gggaggaggc ctacgccacc tggcaggcgg agatcgccgc
    14041 ggcccgggag gcggcgcgcg ggcgctcgct ggacgaccgc ggcttcgccc cgcaccgcaa
    14101 caaggaattc gacctgcggt ggatctacat gcacatgatc gaggagtacg cgcgccacaa
    14161 cggccacgcc gacctcatcc gtgagcggat cgacggggcg accggcgcct gagccatgcc
    14221 ggacgcatga tcgcacatca cccgtgcggg taattcccaa tgcggacgac cgcacagcag
    14281 agttgagcga gtgcatcgac tgcctgcagt gacggtcatg gcggcggtgg cgatggcggc
    14341 cgccgggtgt gtgtccgtct cccagccgcc cgcctcccac tccccgcccc gcccgccggg
    14401 ccactcccgg acgggcgagc tcctgcccgg tcccgcccgc gaggatctga tcaccacggg
    14461 tcccgacgga gcgcccgtgc ccacggctcc cgggcaggac ccgagagccg ccacggccgg
    14521 gggcgcatcg ggcccggagg gcgcgatcac cccctccggc cgctccggcg ccggggacca
    14581 ccacgaccgg gcggatccct acggcttcgg cgacgccccg gagctgcggc cgtccgacgg
    14641 cgaagcggag ccgtcgcgct cctccggctt cccgcggatc tcgcacccgc cccggagggc
    14701 gggccgcccg tgggcctcgc cggaccggcc cgcatccccg gacctcagcc cgtccttccc
    14761 gcggagcgag gtgccctcct cgccgtcgga gcagcgcacc gccgactccc cgcccgcatc
    14821 cgcttcccgc cgggaagcgc cgccgcccgc gcaggcgccg ccaccggcgc aggcgcccgc
    14881 accccgtgcc cgtaacaaca atgtctgcgc gctgggccgg cagcacgggc gctggcagca
    14941 gggcggcgac gcgtcacgga tctgcgactc ggtgtacggg cactgacgca ccgccgcggg
    15001 gcggccgggc gcggtcagac ggccggcacg gccgccaggt cggggatgcg ccagtcgatg
    15061 ggctcgtggc cctgggccgc gaccgcctcg ttgatctggc tgaagggtcg gctgccgaag
    15121 aacttcttcg ccgacagcgg cgacgggtgg gcgcccttga ccacgacgtg ccggctctcg
    15181 tcgatcaggg gcagcttctt ctgggcgtag ttgccccaga gcacgaagac ggccgggtcg
    15241 ggccgggacg ccacggcgcg gatgaccgcg tcggtgaact tctcccagcc cttgcccttg
    15301 tgggaattgg gctccccgcc acggaccgtc agcacggcgt tgagcagcag gacgccctgc
    15361 tcggcccacg gctggagata gccgttgtcc gggacgtcat agccgagctc ctcgcgcatc
    15421 tccttgtaga tgttgcgcag ggagggcggg gtcttcacgc cggggcggac ggagaagcac
    15481 aggccgtggc cctggcccgc gccgtggtag gggtcctggc cgaggatgag gaccttgacc
    15541 tggtcgtacg gggtggcttc cagggctgcg aagacctccc cgcgcggcgg gtacaccggc
    15601 gccttcgtgc gctcctcctc cacgaagtcg gtgagctcct tgaagtaggg cttgtccagc
    15661 tcctcggcga ggacaccgtg ccaggactgg ggcagcacgt cggtgacggt cacgtcaaca
    15721 acctccgggg ttcgttccgt tctcgtggaa gaacttaccg gcgaccactg acaacggccg
    15781 ccgcccgccc ccgcacccgg tgccgccccg gcctcagaac cccgcgttca ggaagatccc
    15841 gccgtccacg acgagggtct gcccggtgat ccaccccgcg tcgtccgaga gcaggaacgc
    15901 ggccgctccc ccgatgtcct cggggacgcc gaggcggccg agcgggtacg aggccacgac
    15961 ctcctcctcg cgcccctcgt agagggcggc ggcgaacttc gtcttgacga cggccggcgc
    16021 gatggagttg acccgcaccc ccggggcgaa ctcgtgcgcg agctgcagcg tgaggttgac
    16081 catcgcggcc ttgctcatgc cgtacgcccc gacgaacggg gaggcggaga tcccggcgac
    16141 ggaggcgata ttgacgatcg caccgccgtg gtccttctgc cacgcccgcc acgtctgctg
    16201 cgcgaagccg agggcggaga tcacattggt ctcgaagacc ttgcgggcga cgccgaggtc
    16261 gagctccgcc atggggccga acacggggtt cgtcccggcg ttgttgacca ggtagtcgat
    16321 gcggccgaac tcctccatcg cgtgctgcac ggcggcggcc tggtgggcct cgtcgtgggc
    16381 cttgcccgcg atgccgatcg cccggcccgc gccgagcgac tccacggcct gcttgagggc
    16441 gtcctcgttg cggccggtga tcacgacgcg gtcgccgcgg gcgacgagcg cctgcgcgat
    16501 gccgtagccg atgccgcggc tcgcgccggt gacgagggcg accctgccgg tgtcctgccg
    16561 cccggcctgc ccccgctgct cctgctcctg ctcctgctgt gcagtcatct ccgtgcttcc
    16621 tgtcagttga gcggtccgcc ggccacgtac agcacctgtc ccgagacgaa gcccgcctcc
    16681 tcgccggtga agaaggcgac ggcgttggcg atgtcctcgg gctcgcccac gcgctccacc
    16741 gggatctgcg tcgccgcggc ggccttgaag tcctcgaagg tcatgccgag gcgggccgcg
    16801 gtggcggccg tcatctcggt ggcgatgaag ccgggggcga cggagttggc ggtgatgccg
    16861 aacttcccga gctccttggc gagcgacttg gtcaggccct gcacgccggc cttggcggcg
    16921 gcgtagttgg cctggccgcg gttgccgagg gcggagctgc tggagaggtt gactatgcgg
    16981 ccgaagcgcg cgtccaccat gtgcttctgg caggcgcgcg acatcaggaa cgcgccccgc
    17041 aggtgcacgc tcatgacggt gtcccagtcg ctctcgctca tcttgaacag caggttgtca
    17101 cgggtcacgc ccgcgttgtt gacgaggatg agcggcgcgc ccagctcggc ggcgatccgg
    17161 gtgacggcgg cgtccacccg gtcggcgtcg gagacgtcgc agccgacggc gagggcccgg
    17221 ccgcccgccg cggtgatctg ctcgacggtg cccgcgcagg cctcctcgtc gaggtcgagg
    17281 acggcgaccg cgcggccctc ccgggccagg cgcagggcgg tcgcggcgcc gatgccgcgg
    17341 gccgcgcccg tgacgacggc cacgcgctgc tcggactcag gcatacgggg atctcctcac
    17401 ctcgaaggcg gcccgcccgc ccggcgcccg gccggacggg tgagcaaccg cttagtagct
    17461 tcggcggatc agacgctaga agccccgcca cccgctgtca acgccttccc gcacgccttg
    17521 cacctcacct caccagcagg tccagcagcc gctccggctc gctctccgga tccgccgtca
    17581 ggccggcgtg cacggggccg ggctgtacga ccgtactgcg gggagcgatc agccagcgga
    17641 agcggcgccc cgggtcgtcc ccggcggcct gcccggcgcg ctccccgccg aggcagacgc
    17701 cctcgacggc gcagagcgcg gcgcgcacgc ccgccacgtc cgccgtcggg tcgagggcca
    17761 gcagccgcgc ctcgtccagg tggacgcggg cggcgacgta gcccttggcc tggcagtaga
    17821 cgacgacccc ggcgttgatc tgctcaccgc gctcgacgcg cgggacgacc cgcagcagcg
    17881 cgtactcgaa tacttcgcgt ccgttgtggc gcccggtcac gtcccggccc ttccgtcgag
    17941 cctgacacgc acccactccg gcgcctgcga gggcttgtcc ttgctgcgtt cgccgaccgt
    18001 gatccggtcg ccgatgccct tcgcccgctc cagcagcacc tcgacgtagg cccggcgcac
    18061 cgcgtcgggg ccgtcgaagc ccggctcgtc cgcgagccac tcgtcgggca cgtcggcggc
    18121 gacctcggtc agcagttcct cggtgacgcg cggcgcgagc tcggccgcgg ccgcggcgag
    18181 gtccgggccg aaggtggcga ggacgtggtc ggaggcgtcg taggccttgc ccgcggccgc
    18241 ggccgcaccc ggccagttgt ggtgccagat catggtggcg ccgtggtcga tgagccacag
    18301 ctcgccgtgc cacacgagca ggttcgggtt gcgccaggag cggtcgacgt tgttgatgag
    18361 cgcgtcgaac cagatcacac ggccggcctc ggccgcgccg acctcgaagg cgagcgggtc
    18421 gaagccgagc gcgccgggca ggaagtccat ggcgaggttg agcccgccgc tggccttgag
    18481 cagcccttgc acctcctggt ccggctcgcc gcggccgatg accgggtcga gctggatgcg
    18541 tgccaggtcc gggacgcgca ggccgagggc gcggccgagc tgtccgcaga cgacctcggc
    18601 gaccagcgtc ttgcggccct gacccgcacc ggtgaatttc atgacgtacg taccgagatc
    18661 gtcggcctcg acgatgccgg ggagcgagcc gccctcacgc aacggtgtca cgtatcgggt
    18721 ggctgtgact tcggggagca ttgccccagg ctactggggg gcttcggcag ccctttgaac
    18781 gcgggcggca ccggctccgt acgactgcct gaacctgcac gttcagagga gcgaacatga
    18841 accacacgtc acggaccgct tcccccgctt ccgccggatc cacggcaccc accggctcca
    18901 cggactccac cagtcccgcc gcctcccggg ccccgcgcgg ctcgacccgc cgcagcgtcg
    18961 tcgcggcggc gggggccgcc ggtctcgtca ccgtgctcgc cgcgtgcggc ggagggggcg
    19021 gcgacaacga ggacaagggc caggccgagg acaagggcca gggcaaggac aaggaagggg
    19081 agctcgggaa ggtctcggac atccccgagg gcggcggcaa ggtcttcgcg gaccggaaag
    19141 tggtggtgac ccagccggcc aagggcgagt tcaaggcctt ctcggcggtc tgcacccacc
    19201 aggggtgcct ggtcaaggag gtctccgggg gcaccatcaa ctgtccctgc cacgggagca
    19261 ggttcgccgt cgcggacggc agcgtgaagg gcggcccggc gccgcggccg ctccccgagg
    19321 agcaggtctc ggtccacgac ggctcgctgc acctggggtg agcccgggcg ccgcagccct
    19381 gcgtcagccg ctccggggcg tgctccgcca gccgcgcagg acggcctcgg ccgtggtgac
    19441 ggtggcgacg agcgccaggg tgtggctgac catggcggcg gtgtagtccg cgggcacgcc
    19501 ggcgatggcg tcggcgggga cgacggccgt gtagccgagg ttgacggcgt cgaagacggt
    19561 gttggggacg gccacgttgg ccgagacgcc ggtgacgacg agggtgcggc agccgaggtt
    19621 gcgcaggagg gcgtccacgc ccgtgcccgc cagcggcgag agcccgtgca gccgccggac
    19681 gacgaggtcc gcgtcgccga ccgggatcgg gtcggcgacg cggaccgcgc gggtaccggt
    19741 cagctgctgt acgggcagcc gctcggccgc acggaacagg cgggcgttgc ggctggcgcc
    19801 gcggccgtcg gggcggcgct cggcgatggc gtgcacgacc tggacgcccg cgtcgtgcgc
    19861 gcccgcgacc aggcgggcga tgttcacgag ggcgccggag gcgcgggcgg cggccgcgag
    19921 ctcgggcagg gcgctgtcgg ggccgacgac gccgctctgg cactcgacgg tgagcagcac
    19981 ggtcgtcgcg gggtcgagcc gctcggcggg cggatccggc ggcgccatgc tggtcgctcc
    20041 ctcctggggc cggtgtccgg cgggtgaggg ccgggccgcg tgagggtaac gggcattgcg
    20101 ccggaggggg aaggggctca cactttctga cgctcggtca gatatcgggg cgcggggagg
    20161 aagcggggac gggcatgggc atcggcacgg gcttcgaggg caccggcggc ggcgggcgcg
    20221 gcatgggcac gggcgccacc cagcggcggg gccgccggat catgatgacg cggccggagc
    20281 tggactcctt cctcgccggg cagcgcacct gccgggtggc cacggtgggg cgggacgggc
    20341 atccgcacct cagcgcgctg tggttcgcct gggacggatc cgcggtgtgg ctgtactcga
    20401 tcgtctgcag ccgccggtgg gcgcagctgc ggcgcgacgc gcggatcgcg gtgctggtgg
    20461 acgacgggcg ggagtacggg gagctgcgcg gggcggagct gtcgggcacg gccgccttcg
    20521 tcggcgaggc cccgcgcacg ggtgatccct gcccggagct cgccgcgccg gaggcgctgt
    20581 tcaccgccaa gtacttcggg ggcctgccgt ccatgccgta cgacggccgc cacgcctggc
    20641 tccggctgct gccggaggcg gtcgtgtcct gggacttccg caagctgccg ggcgcgccgg
    20701 gcactccagg cactgcaggc actccgggcg gctaggcgga acccgccatc gcctcccccg
    20761 ccgccctcag cgcctcgacc gccgcgcgga tggacggccg ccggtccgcg tccgcgcgcc
    20821 agatcgcgta gacgtgacgg cgtacggtgt gccgcacggg caccacgcgc accccctccg
    20881 ggacggggcc gcgcccgagc
//
