LOCUS       NZ_BMUT01000011        21074 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces hiroshimensis strain JCM 4586 sequence11, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUT01000011
VERSION     NZ_BMUT01000011.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces hiroshimensis
  ORGANISM  Streptomyces hiroshimensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 332845)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 90X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650335.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:32:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,830
            CDSs (total)                      :: 6,745
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 25 of 125
            Pseudo Genes (incomplete)         :: 107 of 125
            Pseudo Genes (internal stop)      :: 4 of 125
            Pseudo Genes (multiple problems)  :: 11 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 85232
            Orig. end                         :: 106306
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUT01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="terpene-precursor"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11074)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(431..446)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.61"
                     /tool="antismash"
     misc_feature    432..445
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.35"
                     /tool="antismash"
     misc_feature    478..487
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.63"
                     /tool="antismash"
     gene            complement(661..1392)
                     /locus_tag="IE241_RS24050"
                     /old_locus_tag="GCM10010324_49130"
     CDS             complement(661..1392)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454911.1"
                     /locus_tag="IE241_RS24050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49130"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190023904.1"
                     /transl_table=11
                     /translation="MNVVPQPPHSPEPPHSPQPPQAPPIRVLLVDDDPLVRAGLSFMLG
                     GLPDIRIVGEASDGSEVAALVDRHTPDVVLMDIRMPSVDGLAATEELRRREGAPEVVVL
                     TTFHADEQVLRALRAGAAGFVLKDTPPAEIVAAVRRVASGEPVLSPAVTQQLITRVTEQ
                     ERDTRGDRARALLAGLNDREREVAACVGRGQSNAEIAGALYMSVATVKTHVSRVLTKLG
                     LNNRVQIALLVHDAGGPGAEA"
     gene            complement(1389..2573)
                     /locus_tag="IE241_RS24055"
                     /old_locus_tag="GCM10010324_49140"
     CDS             complement(1389..2573)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020610300.1"
                     /locus_tag="IE241_RS24055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49140"
                     /product="sensor histidine kinase"
                     /protein_id="WP_190023905.1"
                     /transl_table=11
                     /translation="MDVKTEETAEVRPRKSRSVRDWAVDILCIALAAVIGILAAEALRK
                     DPDASRALLFSDQIVGALACVALWMRRRWPVPLAVTLLVVSIVVPTAAGAMLVAVFTVA
                     VHRPFRTVATVGGLALISEPLQAAIRPDPTLRFPAATATGVLLVLTVIGWGMFVRSRRQ
                     LVLSLRERARRAEAEAQLRAERAQRLARERIAREMHDVLAHRLSLLCVHAGALEFRPDA
                     PPAEVARAAGVIRDSAHQALEDLREVIGVLRAPGAEGGGDRPQPTLAALEELVEESRQA
                     GTEVKLDQRVTDAPSVPEATGRTVYRIVQEALTNARKHAGGAAVSVIVEGSPEAGLTLG
                     ISNPPGDGSGAAVPGSGQGLIGLAERAALAGGRLSHGPTPDGGFRVDGWLPWRP"
     gene            2774..3019
                     /locus_tag="IE241_RS24060"
                     /old_locus_tag="GCM10010324_49150"
     CDS             2774..3019
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE241_RS24060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010324_49150"
                     /product="hypothetical protein"
                     /protein_id="WP_190023906.1"
                     /transl_table=11
                     /translation="MKKLLEGVGIILLLQGLGGVVHGLTGWLHYWVVVRYLGFLDGYEM
                     YVSIVLAVLGTALLIASDAVKPEAGAGAGSADRSGG"
     gene            3114..3674
                     /locus_tag="IE241_RS24065"
                     /old_locus_tag="GCM10010324_49160"
     CDS             3114..3674
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017936.5"
                     /locus_tag="IE241_RS24065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49160"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_190023907.1"
                     /transl_table=11
                     /translation="MADRTPGTSELVALLGLQPHVEGGWFRETWKTSREAVPDGYGGPR
                     AFATGIHYLLHPGEVSRWHRVRSDELWLWHRGGPLRMRLGGSGDAPDDAPDGKGAAEAI
                     VGPGVERGERPQFLVPGGVWQSAEPAGDEPVLVTCVVAPGFDYEDFEDSGDPESSGDPE
                     SSGASEGSGGSEASGDSGRPARG"
     gene            3803..4954
                     /locus_tag="IE241_RS24070"
                     /old_locus_tag="GCM10010324_49170"
     CDS             3803..4954
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180036.1"
                     /locus_tag="IE241_RS24070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49170"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190023908.1"
                     /transl_table=11
                     /translation="MGRFKRTLVAAALATTVVAGTAGWAVGNEQAVVTGPPAGAEAWRA
                     DHSLHRELPDPATAAPRTVAAFFAGLTEAQRKDLAARHALVVGNLDGAPVTLRYEANAR
                     AIAAEREKAQAAAADSGLPRSVRAEARERADRCERLLAPGRRILAFDPRGRGQVAEVYG
                     DLATARHTAVIVPGSDIDLRTFDRTNDRYGTPAGMAASLRAEMEHRAPGTPTAVIAWAG
                     YTTPVGLGVDAATGRLAQAGAVRLERLLAGLAAAAASPAAPPPAVFCHSYGSVVCGLAA
                     PSVDRTEAADLVALGSPGMRADSVAGLHTGARVWAAARNSSDWIGNVPNVDLFGLGHGT
                     DPTSPGFGARVVPTRGAHGHTGYFAPGTESLRNFADIALGTYA"
     misc_feature    4977..4990
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.12"
                     /tool="antismash"
     misc_feature    complement(4978..4991)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.02"
                     /tool="antismash"
     misc_feature    complement(4979..4992)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.12"
                     /tool="antismash"
     gene            5017..5658
                     /locus_tag="IE241_RS24075"
                     /old_locus_tag="GCM10010324_49180"
     CDS             5017..5658
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087269.1"
                     /locus_tag="IE241_RS24075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49180"
                     /product="transcriptional regulator"
                     /protein_id="WP_190023909.1"
                     /transl_table=11
                     /translation="MTHVVLDAKGLRALAHPVRVQLVGLLRLYGPSTATRLAERLGLAS
                     GATSYHLRQLAAAGFVEEDASLGNARERWWRAVHEATVIDDDELAEQEPEAMLGYVQGI
                     VAAHTLRAQLAVAAYPALPKPWRDAFNMSDWNLRLTPQEAAELSGELRAVIERYRQHAP
                     GADAPADSEHVALTLHLLPDPAVAEGHAEGRTESGAGAGAGAGADGRERS"
     gene            5655..7034
                     /locus_tag="IE241_RS24080"
                     /old_locus_tag="GCM10010324_49190"
     CDS             5655..7034
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575731.1"
                     /locus_tag="IE241_RS24080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49190"
                     /product="MFS transporter"
                     /protein_id="WP_190023910.1"
                     /transl_table=11
                     /translation="MTPPAPQRGRISGRPPHPRRPDGAPGASSAGRSIRPLAGVLAATA
                     VSLTGTRVSAVALPWFVLVTTGSATQTGLVAFCEMTPYVLVKMFTGPLVDRVGPRVVSW
                     TADTLSAAAAALIPLLHALDLLPFWLLLGLVASIGAVRGPGDLAKEIMVPEAAERSRVP
                     LERATGLSGVTERLASTVGPAAGGALVALLGPMAGLVVNAVCFALGSLVIALALPRGMG
                     LAAPSGDAPPDVGTGEPAGYWRRFGEGFTFLRGEPLLLTIIVTVGITNLLEAGFMTVLV
                     PVWAEDSGGGPAAIGLTSSAAGIASVCGSVVAAALAHRLRRRPVFFAGFLLVGAPKFVV
                     LACDAPLWAVLVVFAVGGFGGGFLNPILGAVSFERVPRALLGRVRALGDSLAWAGIPLG
                     GLLAGLAVTSAGLVPVLLASGAVYFLTTNLAGLRPEWREMDRRRGAGTPREVPEDIAVR
                     S"
     misc_feature    7083..7097
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.48"
                     /tool="antismash"
     gene            7091..8248
                     /locus_tag="IE241_RS24085"
                     /old_locus_tag="GCM10010324_49200"
     CDS             7091..8248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326598.1"
                     /locus_tag="IE241_RS24085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49200"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190023911.1"
                     /transl_table=11
                     /translation="MLWKSRKTSRRSFVAAALLMAFAAPQMPAVAAAAGRVPETPSAGA
                     PAEVPPQVPAPTGKQPVGTRTLHLVDTSRPDPWKPAAGKRQLMVSLWYPARHQGDRNAP
                     FVSKELSKQVIGKEDLAGIRTNSTLGAAPARKPRPLVVLSPGFGMSRLTLTALGEDLAS
                     RGYAVAAVDHTYEAPVEFPGGRIETCEICAKPDMAAVVRNRAKDFSFLLDRLTAPGSPL
                     AVDRDRIAVVGHSVGGASAVEALRGDKRVDAAVNLDGDFPVDPPAGAVNKPVLLFGAQR
                     AGHMENWNKNWQLLTGWKRWLDVPEGGHMTFTDVPWIADRFALRDQLPPDQVAGAYGSL
                     HGTRSTALTRAYVNAFVDRHLRGVPSPLLDRPSAAYPEVTFMKKP"
     cand_cluster    7511..18873
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    7511..18873
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12510:13873](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12511..13873
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     misc_feature    complement(8286..8298)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            8380..9969
                     /locus_tag="IE241_RS24090"
                     /old_locus_tag="GCM10010324_49210"
     CDS             8380..9969
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (106-487). E-value:
                     2.2e-19. Score: 62.0. Matches aSDomain:
                     nrpspksdomains_IE241_RS24090_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953346.1"
                     /locus_tag="IE241_RS24090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49210"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190023912.1"
                     /sec_met_domain="PF00561 (E-value: 1e-26, bitscore: 88.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEFRKSRRTVSAVSAVSAALAAAVAAAVLPAAAAAAQPRTAAGV
                     SVPERYTSQKLAWQPCPELATMECADMTVPRDWHAPDAGKDLTIAVSRVRASDPAHRRG
                     VLMMAAGGPGGKGLLRPAGVARKAPAIGAVHDIVGFDQRGVGKSTPLECQAQEELDAFF
                     AGDFRDRSPEAVRRVVDNSRKLADSCREKHGDLLPYITTEQTVRDMDLFRSLLGERKIS
                     YYGASYATMIGAYYATLFPQRVERAVLDSNIAFDGTWEAFERGQPKSFQRRFEQDFLPW
                     LAKNDATYHYGRTAAEAKATWERRRSALHDRPLSLGEGKGKTLDPNRFDSGTIQAIYNS
                     QEGFPALAKALAALEHWDTAAPAEQQLVGTLFGSYLSTNFFAEFLSVTCADTPWTRDTG
                     TWIRRSAEDTAKYPLMGARELAFATACAAWPASPAPRVEVTGKGLPPVLMLNSLHDPAT
                     YYEGAQRAHRALRGSRLVTDTGGDHGVYLGGSACADGIVDKYLLSGELPARDVTCERAP
                     LPAPAAQQPAAK"
     aSDomain        8698..9840
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE241_RS24090_Abhydrolase_1.1"
                     /evalue="2.20E-19"
                     /label="IE241_RS24090_Abhydrolase_1.1"
                     /locus_tag="IE241_RS24090"
                     /protein_end="487"
                     /protein_start="106"
                     /score="62.0"
                     /tool="antismash"
                     /translation="MMAAGGPGGKGLLRPAGVARKAPAIGAVHDIVGFDQRGVGKSTPL
                     ECQAQEELDAFFAGDFRDRSPEAVRRVVDNSRKLADSCREKHGDLLPYITTEQTVRDMD
                     LFRSLLGERKISYYGASYATMIGAYYATLFPQRVERAVLDSNIAFDGTWEAFERGQPKS
                     FQRRFEQDFLPWLAKNDATYHYGRTAAEAKATWERRRSALHDRPLSLGEGKGKTLDPNR
                     FDSGTIQAIYNSQEGFPALAKALAALEHWDTAAPAEQQLVGTLFGSYLSTNFFAEFLSV
                     TCADTPWTRDTGTWIRRSAEDTAKYPLMGARELAFATACAAWPASPAPRVEVTGKGLPP
                     VLMLNSLHDPATYYEGAQRAHRALRGSRLVTDTGGDHGVYL"
     gene            complement(10001..11074)
                     /locus_tag="IE241_RS24095"
                     /old_locus_tag="GCM10010324_49220"
     CDS             complement(10001..11074)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987904.1"
                     /locus_tag="IE241_RS24095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49220"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_229899725.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.3e-57, bitscore:
                     188.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAQAGPMPPQTVLRTPAPRSLARARELAEPALRAAVAGLHPLPA
                     RMAAFSFGWCEADGTPSASPGGKGVRQAFALLGAEAVGAPPGAAVQAAVAVELVHTFSL
                     VHDDIMDGDERRRHRDAAWKAFGTGPAVLTGDALFALAVQTVAGSGGEHAGRAVAHLAD
                     CLGELVRGQADDLLFENRPWTGQGAVGVPEYEAMAARKTGALLGCALSLGPVLAGAPPL
                     QTGALAEAGRRLGTAFQIVDDLLGIWGDPRTTGKPVHSDLLRRKKTLPVLAAVALDGGA
                     TGRELARLLGPGAPPDAGAARRAAGLVEAAGGREFALEEAHRHAEAAQDCLRGGGLAEG
                     AAAELAALSAYLLERQL"
     gene            complement(11119..12198)
                     /locus_tag="IE241_RS24100"
                     /old_locus_tag="GCM10010324_49230"
     CDS             complement(11119..12198)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946547.1"
                     /locus_tag="IE241_RS24100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49230"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_190023913.1"
                     /transl_table=11
                     /translation="MYGKAFAPEYRGSLEDLSVNASLEEVLAKAVEQRQRAELDGSALE
                     MAHAELAVAEASRRLGRVADAERAWKASYRAARQAADLGAMAWAVWSGGTLARQRGALA
                     LARRWLAIAAGLAERGDDIVARGYSLAGLAETGRIQGDYQAVGELHEKLLAEARRRGEA
                     RHTVWALEGIAQMHRNSGSYDTALAMFEEAAEISGRADDARGHAWALRGIADVLSLRGE
                     TERALALLSEAEETCRRMKLVSALAYNHKMRGNVLFRAGRYAEAEECYRGALEEFREMA
                     EPRGAALARLGLVKSRARLGHDRAGTAAELEDLHRTLGRIGLLHARRMVEEARAELGMP
                     TDPTDPAEPAAATAARPAA"
     misc_feature    complement(12458..12473)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.1"
                     /tool="antismash"
     gene            12511..13873
                     /locus_tag="IE241_RS24105"
                     /pseudo=""
     CDS             12511..13873
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643869.1"
                     /locus_tag="IE241_RS24105"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 1.2e-94, bitscore: 310.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPGALKTLGTGIGWRPEIADAVAAGPVRADWVEVVAENICPGH
                     LPAPLRRLRERGTTVIPHGVSLGLGGADRPDLARLAALAERAEALGSPLVSEHIAFVRS
                     GGPLTGSPRIEAGHLLPVPRTRDALDVLCENVRIAQDMLPVPLALENIAALLPWPGEEL
                     TEGQFLAELVARTGVRLLIDVANLHTNHVNLGHDPASALDELPLEAIAYVHVAGGVRQD
                     GLWHDTHAHPVTGPVLGVLAELSARVTPPGVLLERDDAFPAPEELAAELDAIRATVAGA
                     RHSSRQDRQDRQDRRQAVAHGV"
     gene            13870..14928
                     /locus_tag="IE241_RS24110"
                     /old_locus_tag="GCM10010324_49260"
     CDS             13870..14928
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="IE241_RS24110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49260"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_190023914.1"
                     /transl_table=11
                     /translation="MIAGIVVATLVTLLALVVPSAWLVVARRRALGDPPPAQGEPELLE
                     VAFLLGGRGRAADTVIAAMCDDGRISLNTGGKLRVERAVAHNAMERGLLGRCGPDWGTS
                     LRRLRTSLQFDGAVDGLERSLVRRGMLVSPVVQQKWRRAADVQVAGLVLAGVGVVALLG
                     MPATSVLPVVVLALLIGGIVLRVRCRPAGPKTQPTPRGKAFADRVRTTGPWSTRAPGAH
                     PEGTAGVVAVHGAGGPEPDRPFLRQLRQAALSGTGAGSVRSRSGNAKKPSSRKSKSSYS
                     SSSYSSSSSSSSYSSGGYSCSGASSCSSSSGHSGHSGHSGHSGHSSCSSSSSSCSSSSS
                     GSSCGGGSSCGS"
     gene            15068..16690
                     /locus_tag="IE241_RS24115"
                     /old_locus_tag="GCM10010324_49270"
     CDS             15068..16690
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004956185.1"
                     /locus_tag="IE241_RS24115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49270"
                     /product="phospholipase D-like domain-containing protein"
                     /protein_id="WP_190023915.1"
                     /transl_table=11
                     /translation="MARHRLRRLNRPAAVSAAVSALALAVLPAAPASADSSATPHLDAV
                     EQALRQVSPGLEGRVWERTAGNALDASSGDPADWLLQTPGCWGDATCAERPGTKRLLAK
                     MTENISRATRTVDISTLAPFPDGAFQDAIAEGLKKSVENGNKPKVRVLVGAAPVYHMNV
                     LPTKYRDDLREKLGKAAGSVTLNVASMTTSKTAFSWNHSKLLVVDGQSAITGGINSWKG
                     DYVDTTHPVSDVDLALTGPAAGSAGRYLDELWSWTCRNKSNIASVWFAASDGAACMPTM
                     EKDANPAAAPATGNVPVIAVGGLGVGIQDSDPSSSFRPDLPAASDTKCVVGLHDNTNAD
                     RDYDTANPEESALRALVASARSHVEISQQDLNATCPPLPRYDIRLYDALAAKLAAGVKV
                     RIVVSDPANRGAVGSGGYSQIKSLNEISDTLRNRLAPITGGQQGAKTAMCGNLQLATAR
                     SSDSAKWADGKPYAQHHKLVSVDGSAFYIGSKNLYPSWLQDFGYMVESPEAAQQLDAKL
                     LAPQWKYSQATATFDYARGICQG"
     misc_feature    15092..15094
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16831..18072)
                     /locus_tag="IE241_RS24120"
                     /old_locus_tag="GCM10010324_49280"
     CDS             complement(16831..18072)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010473878.1"
                     /locus_tag="IE241_RS24120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49280"
                     /product="serine hydrolase"
                     /protein_id="WP_190023916.1"
                     /transl_table=11
                     /translation="MNVRTRTVHRALAGALAAAAMAAAALTAPAAAEAADAPSAAGGGH
                     GRHSATRSAMEAQVAAGIPGVLGQARDDHGTWRASAGVGDRTTQRPRLPQDRFRIASIS
                     KVFTSVVLLQLEAEGRIGLDDSVERWLPGVVRGNGHDGREITVRQLLNHTSGIYNYSED
                     PGFQKLIGPDFLEHRFDTYTPDALVKVATAHAPYFRPGGGWHYSNTNYVLAGMITEKVT
                     GHSYATEINRRIIRPLGLTATTLPGTAPELPNPHGRAYSTLLAEPAPDPKIYDVTELNP
                     SWGGAAGEIISTTGDLNRFYGALIGGKLLPKAQQRELLTGVSASDQMPGVRYGLGVYTA
                     PLSCGVTVWMHTGGIHGSASIAASTLDGRHTAAFNFNGDWTGDLGALIEAEYCGKAPSG
                     PSATLKPQKTMTLR"
     misc_feature    complement(18198..18213)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     misc_feature    18490..18502
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            18581..19384
                     /locus_tag="IE241_RS24125"
                     /old_locus_tag="GCM10010324_49290"
     CDS             18581..19384
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004956382.1"
                     /locus_tag="IE241_RS24125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49290"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_190023917.1"
                     /transl_table=11
                     /translation="MPYVRHWLRNSVLLFAVAIALGLVAVHTDLIQPHDLKLDRTVQTT
                     FRTEWLNVVMEGVSALASPIAGLLILVVWSGWLLFVRRRPVTAVSTFLVVAIGWNSTQI
                     AKAIVARPRPPREFMLDPEIGSNSFPSGHTAFTVAAFIAAYFLFRESRHRRTVAVVGVF
                     AVLLVAFSRWYVGAHYPTDTLGSVLIASSAIIFVTGVWHAWLLPRLYRIPLLERFGLDE
                     ELAELEAAERHGGHHGHTRPVPHSRRRGGGGGTPAGGRHRRHAGR"
     misc_feature    complement(19499..19513)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.9"
                     /tool="antismash"
     gene            19571..20758
                     /locus_tag="IE241_RS24130"
                     /old_locus_tag="GCM10010324_49300"
     CDS             19571..20758
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069051.1"
                     /locus_tag="IE241_RS24130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_49300"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_190023918.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.4e-24, bitscore:
                     79.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.9e-21, bitscore:
                     68.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.2e-31, bitscore:
                     102.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLEYTPEQRRFRAELRDYFAGLVAGRAHARHDDPAEQKRFYRAT
                     IRRLGADGRLGTGWPVEYGGSGRTPMEQFIFFDEAAQAGVPLPLMALNTVGPTLMQFGT
                     AEQKAYFLPRILSGELDFAIGYSEPDAGTDLASLRTRAVREGDTYVVNGQKIWTTNGDT
                     ADWIWLAVRTTPVTDGTPPHKGITLLLVPTSAPGYSCTTINTLASHSTTAGYYEDVRVP
                     VRNRVGEENKGWRLITTQLNHERVTLAAHGTTAISALRDVRRWAAATKLADGRRVIDLG
                     WVRARLARTHLRLEAMKLLNWQMVDALQRSALTPQDASAVKVYGSEARRDAYAWLMEVL
                     AAAGPLKDGSAGAALHGELERGYRSAVIFTFGGGNNEIQREIISWIGLGMPRVRR"
ORIGIN
        1 cgcggacgaa ctcgccccgc ttctcgggca gccgcttgta gccgcgggcg cccgacagct
       61 cgttgcggcc gtcggactcg ccgccggtga ggcagaccgt cacggagggg ccgccgccga
      121 ggatcgactg ctccagctcg ggattcatga agtagagcga gtcgtcgggg tgggcgatga
      181 cgtgtacgaa cgactcggac gtcgtggcct tcgcggggcg taccggggtg ctgtcctgcg
      241 tggccttctt cttcgcctcc ggggagagcc actgccaggc accgaccgca ccggctccga
      301 cgacgatgcc gccgcccgcg acctggagta cacgtcggcg cggtatgtgc ccaggcacag
      361 gtcttccccc actctcccgc gcgtgatgcg cgggtagaaa agcaaagggg cgattagaac
      421 taatcgccca tggatcatga gttcgatcct atgaccggca acctgctgtt tccccgctgt
      481 tttgtaacag ccgtacgtcg gccgcatgta gtttcgtagg cggttgcgca acaccgcccc
      541 acggtcgcga cagggtgacc gacggtcgcg cggcggtagc ggagcggctt gtggaaagcg
      601 cttgtccggt cttcttcgcg ggctgtgccg ggggtgtgcc ggagccggct ccggcggggc
      661 tcaggcctcc gcgccggggc cgcccgcgtc atggacgagc agggcgatct gcacccggtt
      721 gttgaggccg agcttggtga ggacgcgcga gacgtgcgtc ttgaccgtcg ccacgctcat
      781 atagagcgca ccggcgatct ctgcgttcga ctgcccgcgc cccacgcagg ccgcgacctc
      841 ccgctcccgg tcgttgagcc cggccagcag ggcccgcgcg cggtcgccgc gggtgtcccg
      901 ttcctgctcc gtgacccggg tgatcagctg ctgtgtgacg gcgggggaga ggaccggctc
      961 gccggacgcg acccggcgca cggcggcgac gatctccgcc ggcggggtgt ccttgaggac
     1021 gaagcccgcc gccccggcgc gcagggcccg cagcacctgc tcgtcggcgt ggaacgtcgt
     1081 caggacgacg acctccgggg cgccttcgcg gcggcgcagc tcctcggtcg ctgccaggcc
     1141 gtccaccgag ggcatgcgga tgtccatcag caccacgtcg ggcgtgtgcc ggtcgaccag
     1201 ggcggccacc tccgagccgt cggaggcttc cccgacgatg cggatgtcgg gcaggccgcc
     1261 cagcatgaac gacagcccgg cccgcaccag cggatcgtcg tccacgagca ggacccggat
     1321 cggcggggcc tgcgggggct gcggcgagtg cggaggctcg gggctgtgcg gcggctgcgg
     1381 gacgacgttc atggccgcca cggtagccag ccgtcgacgc ggaagccgcc gtcgggcgta
     1441 gggccgtggg aaagacggcc gccggcgagg gcggcgcgct cggccagccc gatgagaccc
     1501 tgcccggacc cgggcacggc tgcgccgctc ccgtcacccg gcggattgct gatcccgagc
     1561 gtcagccccg cctccgggga accctcgact atgacgctca ccgccgcccc tccggcgtgc
     1621 ttacgggcat tggtgagcgc ctcctgcacg atccggtaca ccgtgcggcc cgtggcctcc
     1681 ggaaccgagg gggcgtccgt cacccgctgg tcgagcttca cctctgtgcc cgcctgacgg
     1741 gactcctcca ccagctcctc cagcgccgcc agggtgggct gcgggcggtc gcccccgccc
     1801 tccgcgccgg gggcgcgcag caccccgatc acctcgcgca gatcctccag ggcctggtgc
     1861 gcactgtcac ggatcacccc ggcggcccgg gccacctccg cgggcggtgc gtccgggcgg
     1921 aactccagcg cccccgcgtg cacgcacagc agcgacagcc ggtgcgcgag gacgtcgtgc
     1981 atctcccggg cgatgcgctc ccgggccagg cgctgggccc gctccgcccg cagctgcgcc
     2041 tccgcctccg cgcgccgggc gcgctcgcgc agcgacagga ccagctggcg ccgggaccgg
     2101 acgaacatgc cccagccgat gacggtgagg accagcagca cgcccgtggc ggtcgctgcg
     2161 gggaacctca gggtggggtc ggggcggatc gccgcctgca gcggctcgct gatcagggcg
     2221 agcccgccca cggtggccac ggtccggaac ggccggtgca ccgccaccgt gaacaccgcg
     2281 acgagcatgg cccctgcggc ggtcggcacc acgatgctca cgaccagcag cgtcaccgcg
     2341 agcggcaccg gccaccggcg gcgcatccac agcgcgacgc aggccagggc gcccacgatc
     2401 tggtcggaga agaggagcgc gcgcgaggcg tccggatcct tgcgcagggc ctcggcggcc
     2461 agtatcccga tcacggccgc gagggcgatg cagaggatgt cgaccgccca gtcgcgcaca
     2521 ctgcgcgact tacgcggccg cacctccgcc gtctcctcgg tcttcacgtc catgaacagc
     2581 caatttaccg acgcggcgag cggaccggag gcgccggacg gaggcccgat accaaagttg
     2641 cacgaggcgg gaccttggat gattcgggcg ggaccttggg tgatccgagg ggccgcgggc
     2701 ggctacttcg gttcgcgccg cgcagccttc cgggcgatga ccggggcagt gcggcggcag
     2761 gagcatggcg ggtatgaaga agctgctcga aggcgtcggc atcatcctgc tcctgcaggg
     2821 gctgggcggc gtcgtccacg gactcaccgg ctggctccac tactgggtgg tcgtgcgcta
     2881 cctgggattc ctcgacggtt acgagatgta cgtgagcatc gtcctcgccg tcctgggcac
     2941 ggccctgctc atagcctcgg acgcggtcaa gcccgaggcc ggggccgggg ccggttccgc
     3001 cgaccggtcc ggcggctgag gggggcgacg gtgaggggcg gagaaggtga ggggcgggac
     3061 gaggaaggcg attccggggg cgtccgggcg tggggccgcg cgagaatgcc ctcatggctg
     3121 acaggactcc cggcacttcg gaactggtcg cactcctcgg cctccaacca cacgtcgaag
     3181 gagggtggtt ccgcgagacg tggaagacct cgcgcgaggc ggtccccgac ggctacggcg
     3241 ggccgcgggc gttcgccaca ggcatccact acctcctcca ccccggcgag gtatcccgct
     3301 ggcaccgcgt gcgctccgac gaactgtggc tgtggcaccg cggcggcccg ctgcggatgc
     3361 ggctcggcgg ctccggtgac gcacccgacg acgcacccga cgggaagggg gccgccgaag
     3421 cgatcgtcgg gcccggcgtc gagcggggcg agcgaccgca gttcctggtg cccggcggcg
     3481 tgtggcagtc ggccgagccc gcgggggacg agccggtcct ggtgacgtgc gtggtcgcgc
     3541 cgggcttcga ctacgaggac ttcgaggatt ccggggaccc tgagagctcc ggagaccctg
     3601 agagctccgg agcctccgag ggctctggag gctctgaagc ctccggcgac tccgggcgcc
     3661 ctgcgcgggg gtgacggcgc gcgccctcgc cgacccccta ctgaggtatc actccacggt
     3721 tggctccgtg gggtgacgca gctccgggca ccctcttcct agctttccct ccgtcacgcc
     3781 acgggacgag ggagagacat tcatgggccg cttcaagcgc acgctggtcg ccgcagctct
     3841 ggccaccacg gtggtggccg gcacggcggg ctgggccgtc ggcaacgagc aggccgtggt
     3901 caccggcccg cccgccggcg ccgaggcgtg gcgagcggac cactcgctcc accgcgagct
     3961 gccggacccc gcgacggcgg ccccgcgtac ggtcgccgcg ttcttcgccg ggctcaccga
     4021 ggcgcagcgc aaggacctgg cggcccgtca cgctctggtc gtcggcaacc tcgacggcgc
     4081 acccgtgacc ctgcggtacg aggccaacgc ccgcgcgata gccgccgagc gggagaaggc
     4141 gcaggccgcg gccgcggact ccggcctgcc ccgctccgtg cgggcagagg cacgggagcg
     4201 ggccgaccgc tgcgagcggc tgctcgcgcc gggccgccgg atcctggcct tcgacccgcg
     4261 cggccgcggc caggtcgccg aggtgtacgg cgatctggcg acggcccggc acaccgccgt
     4321 catcgtgccc ggctcggaca tcgacctccg caccttcgac cggacgaacg accgctacgg
     4381 cacccccgcc gggatggccg cctccctgcg ggccgagatg gagcacaggg cgcccggcac
     4441 ccccaccgcg gtcatcgcct gggccggcta caccacgccc gtgggcctcg gcgtggacgc
     4501 cgccaccggc cggctcgcgc aggccggggc cgtgcgcctg gaacgcctgc tcgccgggct
     4561 cgcggcggcc gccgcctctc ccgccgcgcc gccgcccgcc gtcttctgcc acagctacgg
     4621 ctcggtggtc tgcggcctgg ccgcgccctc cgtcgaccgc accgaggccg ccgatctcgt
     4681 ggcgctcggc agccccggca tgcgggccga ctccgtggcc gggctgcaca ccggcgcccg
     4741 cgtctgggcc gccgcgcgca actcctcgga ctggataggc aacgtgccca acgtcgacct
     4801 cttcggcctc ggccacggca ccgaccccac ctccccgggg ttcggcgccc gcgtcgtccc
     4861 cacccgcggc gcccacggcc acaccggcta cttcgccccc ggcacggaat ccctgcgcaa
     4921 cttcgcggac atcgccctcg gcacctacgc ctagacccgg cctcagactg ccaaggtttc
     4981 tttgcaaaga aaccttggca gtctagagtg cggggaatga cccatgtcgt tctcgacgcc
     5041 aagggcctgc gtgccctggc ccaccccgta cgcgtgcaac tcgtggggct gctgcggctg
     5101 tacggcccct cgacggccac ccggctcgcc gagcgcctcg gcctggcctc cggggcgacc
     5161 agttaccacc tccggcagct cgccgccgcg ggcttcgtcg aggaggacgc ttcgctgggc
     5221 aacgcccgcg aacgctggtg gcgtgccgtc cacgaggcca ccgtgatcga cgacgacgag
     5281 ctcgccgagc aggagccgga ggccatgctc ggctatgtcc agggcatcgt ggccgcccac
     5341 accctccgcg cccagctggc cgtcgccgcg tacccggccc tgccgaagcc ctggcgggac
     5401 gccttcaaca tgagcgactg gaatctgcgg ctcaccccgc aggaagccgc ggagctgtcc
     5461 ggggagctcc gtgcggtcat cgaacgctac cggcagcacg cgcccggcgc ggacgccccc
     5521 gcggacagcg agcacgtcgc gctcaccctg cacctcctgc ccgaccctgc cgtcgcggag
     5581 ggccatgcgg agggccgtac ggagagcggc gcgggagccg gtgcgggagc cggtgccgac
     5641 gggcgggaaa ggtcatgacc ccgccggcgc cgcagcgcgg ccggatatcc ggccgcccgc
     5701 cgcacccccg tcgcccggac ggagctccag gcgcttcctc cgcaggccgc agcatccgtc
     5761 cgctcgccgg agtcctcgcg gcgacggccg tctccctgac gggcacccgc gtctcggcgg
     5821 tcgccctgcc gtggttcgtg ctcgtcacca caggcagcgc cacgcagacc ggactcgtcg
     5881 ccttctgcga gatgactccg tacgtcctgg tcaagatgtt caccggcccc ctggtggacc
     5941 gcgtcggacc gcgcgtcgtc tcctggacgg ccgacaccct cagtgccgcc gctgccgcgc
     6001 tgatccccct gctccacgcc ctggacctgc tgccgttctg gctgctgctc ggcctcgtcg
     6061 cgtcgatcgg cgccgtgcgc gggcccggcg acctggccaa ggagatcatg gtgccggagg
     6121 cggcggagcg cagccgggtc cccctggagc gggccaccgg cctctccggc gtcaccgagc
     6181 gcctcgcctc cacggtcggc ccggcggccg gcggcgcgct ggtggcgctg ctcggcccca
     6241 tggccggcct ggtcgtcaac gccgtctgct tcgccctggg gtcgctcgtg atcgcgctcg
     6301 cgctcccgcg cggcatgggc ctcgcggcgc cgtccggcga cgcgcccccg gacgtcggga
     6361 cgggcgaacc ggcaggctac tggcgccgct tcggcgaagg cttcaccttc ctgcgcggcg
     6421 agcccctgct gctcacgatc atcgtcacgg tcggcatcac caacctcctc gaggcgggct
     6481 tcatgaccgt cctcgtcccc gtgtgggccg aggactccgg cggcggaccc gcggccatcg
     6541 gcctcaccag cagcgcggcg gggatcgcat ccgtctgcgg cagcgtcgtg gccgccgcgc
     6601 tcgcccaccg gctgcgccgc cgccccgtgt tcttcgcggg cttcctgctc gtgggggcgc
     6661 cgaaattcgt cgtgctcgcc tgcgatgcgc cgctgtgggc ggtgctcgtg gtgttcgcgg
     6721 tcggcggttt cggcggcggg ttcctcaacc ccatcctcgg cgccgtgtcc ttcgagcggg
     6781 tgccgcgcgc cctgctgggc cgggtgcggg cgctgggcga ctccctggcc tgggcgggca
     6841 ttcccctcgg cggtctgctt gccggactcg ccgtcacgtc cgccggcctg gtgcccgtcc
     6901 tcctggcgag cggggcggtg tacttcctca ccaccaacct ggccggactg cgcccggagt
     6961 ggcgcgagat ggaccgccgg cgcggtgccg gcacccctcg cgaagtgccg gaggacattg
     7021 ccgtacgaag ttgatcatct ccgacccgag ggtgacggca ggagtatcac ggccgtataa
     7081 cgtgatgatc atgttgtgga aatcgcgtaa gacgtcgcgg aggtccttcg tggccgccgc
     7141 gctcctgatg gccttcgccg cgccccagat gccggccgtg gccgcggcgg cgggacgggt
     7201 ccccgagacg ccgtcggccg gcgccccggc cgaggtcccg ccccaggtcc cggcccccac
     7261 gggcaagcaa ccggtcggga cgaggaccct gcacctcgtc gacacctcgc gccccgaccc
     7321 ctggaagccc gccgccggca aacggcagct catggtctcg ctctggtacc cggcgcggca
     7381 ccaaggcgac cggaacgccc ccttcgtgtc gaaggagctg tccaagcagg tcatcggcaa
     7441 ggaggatctc gccggtatcc gcaccaactc caccctgggc gccgccccgg cccgcaagcc
     7501 ccggccgctg gtcgtcctct cgccgggctt cggcatgagc cggctgacgc tcaccgcgct
     7561 cggcgaggac ctcgcgtcgc gcggatacgc ggtggccgcg gtcgaccaca cctacgaggc
     7621 ccccgtggaa ttccccggcg ggcgcatcga gacctgcgag atctgcgcga agccggacat
     7681 ggccgcagtc gtacggaacc gggcgaagga cttctccttc ctcctcgacc ggctgaccgc
     7741 tcccggcagc ccgctcgcag tcgaccgcga ccggatcgcc gtggtcggac actccgtcgg
     7801 aggcgcgagc gcggtcgagg ccctgcgcgg cgacaagcgc gtggacgccg ccgtcaacct
     7861 cgacggcgac ttccccgtcg acccgcccgc cggcgcggtc aacaagcccg tgctgctctt
     7921 cggcgcgcag cgggccgggc acatggagaa ctggaacaag aactggcaac tgctgacggg
     7981 ctggaagcgc tggctcgacg tgcccgaagg cggccatatg acgttcacgg acgtcccctg
     8041 gatcgcggac cggttcgcac tgcgcgacca gctcccgccg gaccaggtcg ccggcgccta
     8101 cggcagcctg cacggcaccc gctcgaccgc gctcacccgt gcgtacgtga acgcgttcgt
     8161 cgaccggcac ctgcgcggcg tcccgagccc gctcctggac cggccgtccg cggcctaccc
     8221 cgaggtcacc ttcatgaaga agccctgacg gttcatgaag aagccctgac ggccccctgg
     8281 gggtggtgcc agtgccaccc ccggaacgga taccagcggg gtcgatcacg tccgctccgc
     8341 ccgcgaacat cgaaccgtca ccacgcacca ggaggttcga tgttcgagtt caggaaatca
     8401 cggcggaccg tctccgcggt ctccgccgtg tcggccgcac ttgccgcggc cgtcgcggcc
     8461 gcagtgctcc cggcggcagc ggcggccgcg cagccgcgaa cggccgcggg agtgagcgtg
     8521 cccgagcggt acacctcgca gaagctggcc tggcagccct gtcccgaact ggccaccatg
     8581 gagtgcgcgg acatgaccgt cccgcgcgac tggcacgccc cggacgccgg caaggacctc
     8641 acgatcgccg tctcccgcgt acgggcgagc gaccccgccc accggcgcgg ggtgctgatg
     8701 atggccgcgg gcggccccgg cggcaagggg ctgctgcggc ccgcgggcgt cgcccggaag
     8761 gcgcccgcca tcggtgccgt ccacgacatc gtcggcttcg accagcgcgg cgtcggcaag
     8821 agcacgccgc tggagtgcca ggcccaggaa gagctcgacg ccttcttcgc gggcgacttc
     8881 cgcgaccgct cgcccgaggc cgtccggcgc gtcgtggaca actcccgcaa gctcgccgat
     8941 tcctgccgcg agaagcacgg ggacctcctc ccgtacatca ccaccgagca gaccgtgcgc
     9001 gacatggacc tcttccgctc cctgctcggc gagcggaaga tctcctacta cggggcctcc
     9061 tacgcgacga tgatcggcgc gtactacgcc accctcttcc cgcagcgcgt cgaacgcgcc
     9121 gtcctggaca gcaacatagc cttcgacggc acctgggagg ccttcgagag gggccagccc
     9181 aagagcttcc agcgccgctt cgagcaggac ttcctgccct ggctcgcgaa gaacgacgcc
     9241 acctaccact acggccgcac cgccgccgag gcgaaggcca cgtgggagcg gcgccgcagc
     9301 gcgctgcacg accgcccgct cagcctgggc gagggcaagg gcaagacgct cgaccccaac
     9361 cgcttcgaca gcggcaccat ccaggcgatc tacaactccc aggagggctt cccggctctc
     9421 gcgaaggcgc tcgccgcgct ggagcactgg gacacggcgg cccccgccga gcagcagctc
     9481 gtcggcacgc tcttcggctc ctacctcagc accaacttct tcgccgagtt cctctccgtg
     9541 acctgcgccg acaccccgtg gacccgcgac accggcacgt ggatccggcg cagcgccgag
     9601 gacaccgcca agtaccccct gatgggcgcc cgggaactcg ccttcgccac cgcgtgcgcg
     9661 gcgtggcccg cctccccggc accgcgcgtc gaggtcaccg gcaagggcct gccgcccgtc
     9721 ctgatgctca actccctgca cgacccggcc acgtactacg agggcgcaca gcgcgcccac
     9781 cgggccctgc gcggctcgcg cctggtcacg gacaccggcg gcgaccacgg cgtctacctg
     9841 ggcggcagcg cctgcgccga cggcatcgtg gacaagtacc tcctctccgg agaactgccc
     9901 gcacgtgacg tcacctgcga gcgcgcgccg ctgccggcac cggcggcgca gcagcccgca
     9961 gcgaagtagc cccagggagg gggagagggc ggcagacggg ttacagctgc cgctccagca
    10021 gatacgcgga gagcgcggcg agttcggctg cggcgccctc cgcgagtccg ccgccgcgca
    10081 ggcagtcctg cgcggcctcc gcatggcggt gggcctcctc cagggcgaac tcccggccgc
    10141 cggccgcctc gaccaggccg gccgcgcggc gtgcggcccc ggcgtccggt ggcgcgcccg
    10201 ggcccagcag ccgggccagc tcgcggccgg tcgccccgcc gtccagggcg acggccgcca
    10261 gcaccggcag ggtcttcttc cgccgcagca ggtcgctgtg gacgggcttg cccgtcgtcc
    10321 gcgggtcgcc ccagatcccc agcaggtcgt ccacgatctg gaaggccgtg ccgagccgcc
    10381 gcccggcctc ggccagggca cccgtctgca ggggcggggc gcccgcgagc accggtccca
    10441 gggacagggc gcagccgagc agggcaccgg tcttgcgggc cgccatcgcc tcgtactccg
    10501 gtacgccgac cgccccctgc cccgtccacg ggcggttctc gaacagcagg tcgtcggcct
    10561 gcccgcgcac cagctcgccc aggcagtcgg ccagatgcgc caccgcacgg cccgcgtgct
    10621 cgcccccgga ccccgccacc gtctgcacgg cgagcgcgaa cagggcgtcg cccgtcagga
    10681 cggccggtcc cgtgccgaac gccttccacg ccgcgtcccg gtgccgccgc cgctcgtcgc
    10741 cgtccatgat gtcgtcgtgc accagcgaga acgtgtgcac cagctccacc gccaccgccg
    10801 cctgcaccgc ggccccggga ggagcaccca ccgcctccgc gccgagcagg gcgaacgcct
    10861 ggcggacgcc cttgccgccg ggggaggcgc tcggcgtgcc gtcggcctcg caccagccga
    10921 aggagaaggc cgccatgcgc gccggcagcg ggtgcagccc cgccacggcg gctctgagcg
    10981 cgggctcggc cagctcccgc gcgcgggcga gcgaccgggg cgcgggtgtc cggagtacgg
    11041 tctgcggggg catggggccg gcctgagcgg gcatgtgctt ctctttcctg tcgtgggctg
    11101 ccgcggaagg acgtgctgtc aggcggccgg gcgggccgcc gtggccgccg ccggctccgc
    11161 cgggtccgtc gggtccgtcg gcatccccag ttcggcgcgc gcctcctcga ccatccgccg
    11221 ggcgtggagc aggccgatcc ggccgagcgt acggtgcagg tcctccagtt cggcggcggt
    11281 cccggcgcgg tcgtgcccca gccgggcccg gctcttgacc agccccagcc gggccagggc
    11341 cgcaccccgc ggctccgcca tctcccggaa ctcctccagc gcgccgcggt agcactcctc
    11401 ggcctccgcg taacggcctg cgcggaacag cacgttgccg cgcatcttgt ggttgtaggc
    11461 cagggcgctg acgagcttca tccgccggca cgtctcctcc gcctccgaca gcagcgcgag
    11521 cgcccgctcg gtctcgcccc gaagggacag cacgtcggcg atcccgcgca gcgcccacgc
    11581 gtggccgcgg gcgtcgtcgg cccggcccga tatctccgca gcctcctcga acatggccag
    11641 cgcggtgtcg taggagccgg agttgcggtg catctgcgcg atgccctcca gcgcccacac
    11701 ggtgtgccgg gcctcgccgc ggcgccgcgc ctccgccagc agcttctcgt gcagttcgcc
    11761 gacggcctgg tagtcgccct ggatgcggcc ggtctcggcg aggcccgcca gggagtagcc
    11821 gcgggccacg atgtcgtcgc cccgttcggc gagtccggcg gcgatggcga gccaccgccg
    11881 ggccagggcc agggctccgc gctgccgggc gagggtgccg ccgctccaca cggcccacgc
    11941 catcgccccc aggtccgccg cctgccgcgc ggcccggtag ctcgccttcc acgcgcgctc
    12001 ggcgtccgcc acccggccga ggcgccggct cgcctccgcg acggccagct cggcgtgcgc
    12061 catttcgagg gcggagccgt ccagttcggc ccgctgccgc tgctcgacgg ccttggccag
    12121 cacttcctcg agcgaggcgt tcacagagag gtcttccagg gagccccggt actcgggggc
    12181 gaatgccttg ccgtacatgg ttcagcctca cttcaggatc gctcaggagg gcagggggcg
    12241 ccctgctgat gatcaaaaag ctatggcctt ggaccaccgg gagtaatccg accaggaggc
    12301 ggcgtcccgt acatctgagg tccggtgcgc agggcacggg tcatacgaga gatgtacgag
    12361 cttctcaggg tgccgtacca ccggcagggg gctgcgattt cccctgctga gtttccccgg
    12421 cgaaggattt gtacagtgac ccgcggggaa aacccgctgg tacaggcgtt cggctccacg
    12481 ggggagcacg ggaaagacgg gggcggggcc atgagtgagc cgggtgcgct caaaacgctg
    12541 gggacgggga tcggctggcg gccggagatc gccgacgccg tggcggcggg cccggtccgc
    12601 gccgactggg tggaggtcgt cgcggagaac atctgcccgg gccacctccc cgccccgctc
    12661 cggcggctgc gcgagcgcgg cacgacggtg ataccccacg gggtctccct cggcctgggc
    12721 ggcgccgacc ggccggatct cgcccggctc gccgcgctgg ccgagcgtgc cgaagccctc
    12781 ggctcgccgc tcgtctccga gcacatcgcc ttcgtccggt ccggaggtcc gctgaccggc
    12841 tccccgcgga tcgaggccgg gcacctgctg ccggtgcccc gcacccgcga cgccctggac
    12901 gtcctgtgcg agaacgtccg catcgcacag gacatgctgc ccgtcccgct cgcgctggag
    12961 aacatcgcgg ccctcctgcc ctggcccggc gaggagctga ccgagggaca gttcctcgcc
    13021 gagctggtcg ccaggacggg cgtacggctc ctgatcgacg tcgccaacct ccacacgaac
    13081 cacgtcaacc tgggccacga ccccgcgtcc gccctggacg aactgccgct cgaagccatc
    13141 gcctacgtcc acgtggccgg aggcgtccgg caggacgggc tgtggcacga cacccacgcc
    13201 cacccggtga ccggccccgt cctcggcgtc ctcgccgagc tgtccgcccg cgtgacgccc
    13261 ccgggcgtcc tcctggagcg cgacgacgcc ttccccgcgc ccgaagagct cgcggcggaa
    13321 ctggacgcga tcagagcgac ggtggccggc gcccggcact cttcccggca ggaccggcag
    13381 gaccggcagg accgacggca ggcggtggca cacggtgtct gacgccgccc ggcggcgcct
    13441 cgcgcacgcc cagcacgccc tgctctgcgc gctcgtcgcg gacgcacccc cgccgcacgg
    13501 cttcgacccg cagcggctgc gtgcacagca gcaggcgctg ctcggcaagc gcgcggacgt
    13561 cgtcgccaag atcgcgccgg agctgcccga gatcctcggg gcggacttcc ggcccctgtt
    13621 cctcgcccat gcccgaggcc gtccgatgaa cgacggctac cgccaggacg ccctcgactt
    13681 cgccgaggcg ctcctgcagg ccgacggcat gctcaccgac cccgggcggc gggagcgcct
    13741 cgcggcgtgg acggccggcc ggcgcgcacg ggccgccggt cccaccccgt tccccgctcc
    13801 tttttctgct cgcctggcgt cggcctggca caccctgcgc tcgcgcgtga cccgaaaggc
    13861 aagcgtccta tgatcgccgg catcgtcgtc gccaccctgg tgaccctcct tgccctcgtc
    13921 gtcccctcgg cctggctggt cgtcgcccgc cgccgcgccc tcggcgaccc gccgcccgcc
    13981 cagggcgagc cggagctgct ggaggtcgcg ttcctgctgg gcggccgcgg cagggcggcg
    14041 gacaccgtca tcgccgccat gtgcgacgac ggacggatat ccctgaacac cggcggcaag
    14101 ctcagggtcg agcgggccgt tgcgcacaac gccatggagc gcggcctgct gggccgctgc
    14161 ggccccgact ggggcacctc gctgcgccgg ctccgcacct cgctgcagtt cgacggggcc
    14221 gtcgacggtc tcgaacgctc cctcgtccgg cgcgggatgc tggtgtcgcc cgtggtgcag
    14281 cagaagtggc ggcgcgccgc ggacgtgcag gtggccggtc tcgtcctcgc cggcgtcggc
    14341 gtcgtggccc tgctcggcat gcccgcgacc tccgtgctgc ccgtcgtcgt cctcgccctg
    14401 ctcatcggcg gcatcgtgct ccgcgtccgg tgccggccgg ccgggccgaa gacgcagccc
    14461 acgccgcgcg gcaaggcctt cgccgaccgg gtgcggacaa ccggtccctg gagcacccgg
    14521 gcccccggtg cgcaccccga aggcaccgcg ggtgtcgtcg ccgtgcacgg tgccggcggg
    14581 cccgagccgg accggccgtt cctgcgtcag ctgaggcagg cggcactgtc gggcaccggt
    14641 gcgggcagcg tgcgctcccg ctccgggaac gcgaagaagc cgtcttcccg gaagtcgaag
    14701 tcctcttact cctcctcgtc ctattcctcc tcgtcatcgt cgtcttccta cagcagcggc
    14761 gggtacagct gctccggtgc gtcgagctgt tcgagctcct ccggccactc ggggcattcg
    14821 ggtcactcag gccactccgg tcattcgagc tgctccagct ccagctccag ctgctcctcc
    14881 tccagttcgg gttccagctg cggcggcggc agcagctgcg gctcctgaac ggttcattcc
    14941 gggcagctgg tagcttcacc tcggtgatca tccgcagtgc cggtcccggc gctgcggatc
    15001 gccgtgcgca ctttcgccgc acggcgcgtt cccggtcacc ctccgcaccc ccggacaagg
    15061 aagcacattg gctcgccacc ggctccgccg cttaaaccgt cccgccgcag tctcggcggc
    15121 ggtctccgcc ctcgccctcg ccgtcctccc cgcggccccg gcgtccgccg actcctccgc
    15181 caccccgcac ctcgacgccg tcgagcaggc cctccgccag gtctcgcccg gcctcgaagg
    15241 gcgcgtatgg gagcgcaccg ccggcaacgc gctggacgcc tcctccggcg accccgccga
    15301 ctggctcctg cagacccccg gctgctgggg cgacgccacc tgcgccgagc gccccggcac
    15361 gaagcggctg ctcgccaaga tgaccgagaa catctccagg gccacgcgca ccgtcgacat
    15421 atccaccctg gcgcccttcc ccgacggggc gttccaggac gcgatagccg agggtctgaa
    15481 gaagtcggtg gagaacggca acaagccgaa ggtccgcgtc ctggtcgggg ccgcgccggt
    15541 ctaccacatg aacgtgctgc ccacgaagta ccgtgacgat ctgcgcgaga agctcggcaa
    15601 ggccgccggc agcgtcaccc tgaacgtcgc ctcgatgacg acctcgaaga ccgccttctc
    15661 ctggaaccac tccaagctcc tggtggtgga cgggcagtcg gcgatcaccg gcggcatcaa
    15721 cagctggaag ggcgactacg tcgacaccac ccacccggtg tccgacgtcg acctcgccct
    15781 gaccggtccc gcggccgggt ccgccggccg gtacctggac gagctgtggt cctggacctg
    15841 ccggaacaag agcaacatcg cgagcgtctg gttcgccgcg tccgacggcg ccgcctgcat
    15901 gccgacgatg gagaaggacg cgaaccccgc cgccgccccg gccaccggga acgtccccgt
    15961 gatcgccgtc ggcggcctgg gcgtcggcat ccaggactcc gacccctcct cgtccttccg
    16021 gccggacctg ccggcggcct ccgacaccaa gtgcgtcgtc ggcctgcacg acaacaccaa
    16081 cgccgaccgt gactacgaca cggccaaccc cgaggagagc gccctgcgcg ccctcgtggc
    16141 cagtgcccgc agccacgtgg agatctccca gcaggacctc aatgccacct gtccgccgct
    16201 cccgcgctac gacatccggc tctacgacgc gctcgcggcc aagctggccg ccggcgtgaa
    16261 ggtccgcatc gtcgtcagcg accccgccaa ccgcggcgcg gtcggcagcg gcggctactc
    16321 gcagatcaag tcgctgaacg agatcagcga caccctgcgc aaccgcctcg cgccgatcac
    16381 cggcggtcag cagggcgcga agacggccat gtgcggcaac ctgcagctgg ccactgcccg
    16441 cagctcggac agcgccaagt gggccgacgg caagccgtac gcccagcacc acaagctggt
    16501 ctccgtggac ggctcggcct tctacatcgg ctcgaagaac ctctacccgt cctggctgca
    16561 ggacttcggg tacatggtgg agagcccgga ggccgcacag cagctcgacg cgaagctgct
    16621 ggccccgcag tggaagtact cgcaggccac ggcgaccttc gactacgccc gcgggatctg
    16681 ccagggctga gcccccggcg ctcccgtacg gacctgtgtt cccgtgcgga tctgcgttcc
    16741 cgtgcggatc tgcgttcccg tgcggacctg cggcccgcgg ctgtcaccgg ccgcgggccg
    16801 caggccgtat tgccgcccgg cgcaggtgcg tcagcgcagc gtcatcgtct tctgcggctt
    16861 gagggtggcg gacggccccg agggggcctt gccgcagtac tccgcctcga tcagcgcgcc
    16921 gaggtcgccc gtccagtcgc cgttgaagtt gaacgcggcg gtgtgccggc cgtcgagggt
    16981 cgaggcggcg atcgaggcgg agccgtggat gccgccggtg tgcatccaga cggtcacgcc
    17041 gcacgacagc ggggccgtgt agaccccgag gccgtagcgg acgccgggca tctggtcgct
    17101 tgcggacacc ccggtgagca gctcccgctg ctgggccttc ggcagcagct tcccgccgat
    17161 gagggcgccg tagaagcggt tgaggtcgcc ggtggtcgag atgatctcgc cggcggcccc
    17221 gccccacgac gggttgagct cggtgacgtc gtagatcttc gggtcgggag cgggctcggc
    17281 caggagcgtg ctgtacgccc ggccgtgcgg gttcggcagc tccggcgccg tgcccgggag
    17341 ggtggtggcg gtgagcccca ggggccggat gatgcgccgg ttgatctcgg tggcgtacga
    17401 gtgccccgtc accttctcgg tgatcatgcc ggcgaggacg tagttggtgt tggagtagtg
    17461 ccagcccccg cccggccgga agtacggagc gtgcgccgtc gcgaccttca ccagcgcgtc
    17521 cggcgtgtag gtgtcgaagc ggtgctcgag gaagtccggg ccgatcagct tctggaagcc
    17581 cgggtcctcg gagtagttgt agatcccgct ggtgtggttg agcagctgcc ggacggtgat
    17641 ctcacggccg tcgtggccgt tgccccggac gacgcccggc agccagcgct cgacggagtc
    17701 gtccaggccg atccggccct ccgcctccag ctggagcagg acgacggagg tgaagacctt
    17761 gctgatgctg gcgatgcgga agcggtcctg ggggaggcgg ggccgctggg tggtgcggtc
    17821 gccgacgccg gccgaagccc gccaggtgcc gtggtcgtcc cgggcctgcc ccaggacgcc
    17881 gggtatgccc gccgccacct gggcctccat ggcgctgcgg gtggcggagt gccggccgtg
    17941 gccgccgccg gcggcggacg gggcgtcggc ggcctcggcc gcggcggggg cggtgagggc
    18001 cgccgcggcc atcgcggcgg cggccagtgc ccccgccagg gctctgtgga cggtgcgggt
    18061 gcgtacgttc atggcaggta gcccctctgt tccggcgtgt gtgctgacac cggacaggac
    18121 accgtcaagt cgtacggggt tgaagggcac ttgtgggtgg ggagcggtat ccggccagcg
    18181 ggaacggcgt ccgcgggcgt gaggcacggc acatgttctc ccgtccgggg aaccgttgcc
    18241 cgtgctgcgg cgtcaaggcg atgtaggggt gccggccgcc ccgtcccggg cggctccgtc
    18301 cacgatcggc tgaatcgccg cccgtaccac cgcctccgcg cccggccgga aggtcaccgt
    18361 cggatacaac tccctcacac agggtgctcc ggcggtggtg ggaggcccgc ggaggcggcc
    18421 cgcggcgggc gtccgggcgg gcgtcccgga agggtgcgca tgcggcgcgt gtagctttgc
    18481 cgtacagccg tgccgtcgtc acccctgcgg caggcattcg tcgcctttgc gtgtactgcc
    18541 gtgccggtac cgccctaccc atacaaagga cgccccaccc atgccgtacg tgcgccactg
    18601 gttgcgcaac tcggtcctgc tgttcgccgt cgcgatcgcg ctgggcctgg tagccgtgca
    18661 caccgatctc atccagccgc acgacctgaa gctggaccgc acggtccaga ccactttccg
    18721 caccgagtgg ctgaacgtgg tcatggaggg ggtcagcgcc ctcgcgtccc cgatcgccgg
    18781 cctgctgatc ctggtggtct ggagcggctg gctgctgttc gtgcggcgcc ggccggtgac
    18841 ggcggtctcc accttcctcg tcgtcgcgat cggctggaac agcacccaga tcgcgaaggc
    18901 catcgtcgcc cggccccggc cgccgcggga gttcatgctg gaccccgaga tcggctcgaa
    18961 cagcttcccc agcggtcaca ccgccttcac cgtcgccgcc ttcatcgccg cgtacttcct
    19021 cttccgggag tcccgccacc ggcggaccgt ggccgtcgtc ggtgtcttcg ccgtgctgct
    19081 cgtcgccttc tcccgctggt acgtcggcgc ccactacccg accgacaccc tcggctcggt
    19141 cctgatcgcc tcgtccgcga tcatcttcgt caccggcgtc tggcacgcct ggctgctgcc
    19201 gcggctctac cgcatcccgc tgctggagcg cttcggtctg gacgaggagc tcgccgagct
    19261 ggaggccgcg gagcggcacg gcggccacca cggtcacacc cgccccgtgc cgcacagccg
    19321 ccgccgcggc ggcggagggg gcacgccggc cgggggccgt caccgccggc acgccggccg
    19381 ctgacggccg cggcgccgcc gccgtattcg ccgcacgccg tatccgccgt atccgccgta
    19441 tccgacaggg acctcgcagg gctgacgccc gcgaggtccc tgctttcgtc cgccttccga
    19501 atttctggaa caggttctac ggtgtgcgcc gtcagcgcgc gcggcatacg gcgagcaccc
    19561 tggaggggcc gtggacctcg aatacacccc ggaacagcgg cgcttccgcg ccgagctgcg
    19621 ggactacttc gccgggctgg tcgcaggccg cgcccacgcc cgccacgacg acccggccga
    19681 gcagaagcgc ttctaccgcg ccacgatccg ccgcctcggc gcggacggcc gcctcgggac
    19741 cggctggccc gtggagtacg ggggcagcgg ccggaccccg atggagcagt tcatcttctt
    19801 cgacgaggcc gcgcaggcgg gcgtaccgct gccgctgatg gccctcaaca ccgtcggccc
    19861 caccctcatg cagttcggca cggccgagca gaaggcgtac ttcctgcccc ggatcctctc
    19921 cggcgagctc gacttcgcca tcggctacag cgagcccgac gccggcaccg acctcgcctc
    19981 cctcaggacg cgggccgtgc gcgagggcga cacctacgtc gtcaacggcc agaagatctg
    20041 gaccaccaac ggcgacaccg ccgactggat ctggctggcc gtccgcacca cccccgtcac
    20101 ggacggcaca ccgccgcaca agggcatcac cctcctcctc gtcccgacca gcgcccccgg
    20161 ctactcctgc accaccatca acaccctcgc ctcccacagc accaccgccg gctactacga
    20221 ggacgtccgc gttcccgtcc gcaaccgcgt cggcgaggag aacaagggct ggcggctgat
    20281 caccacacag ctcaaccacg agcgcgtcac cctcgccgcc cacggcacga cggccatcag
    20341 cgccctgcgc gacgtccggc gctgggccgc cgccaccaag ctcgccgacg gccgccgcgt
    20401 catcgacctc ggctgggtcc gcgcccggct cgcccgcacc catctgcgcc tggaggcgat
    20461 gaagctgctc aactggcaga tggtcgacgc cctgcagcgc tccgccctca ccccccagga
    20521 cgcctccgcc gtcaaggtct acggctccga ggcccgccgc gacgcctacg cctggctcat
    20581 ggaggtcctc gccgcggcgg gccccctcaa ggacggctcc gccggcgccg ccctccacgg
    20641 cgaactggag cgcggctacc gcagcgccgt catcttcacc ttcggcggcg gcaacaacga
    20701 gatccagcgg gagatcatct cctggatcgg cctggggatg ccgcgcgtgc gccgctaacc
    20761 tgacgacgac aggaggtgcc ccatgccgca cgccgacccc gggctcttcg ggcccgcatc
    20821 ggtcacctgg cagctgcacg gcgaccccat gatgtggatc gccggggtgc gcgccctgtg
    20881 gctgcaggcg ctgcacccgc gcgcggtccg cggcgtcacg cagaactccg acttccgcaa
    20941 ggacgcctgg ggccgcctgc gccgcaccgc ggacttcgtg ggcaccacca cgtacggcac
    21001 caccgaggcc gccgagcgcg cgggtgcggc cgtgcgcggc atccaccgca ggctgtccgc
    21061 caccgatccg gaca
//
