LOCUS       NZ_BMUT01000002        22790 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces hiroshimensis strain JCM 4586 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUT01000002
VERSION     NZ_BMUT01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces hiroshimensis
  ORGANISM  Streptomyces hiroshimensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 769107)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 90X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650335.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:32:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,830
            CDSs (total)                      :: 6,745
            Genes (coding)                    :: 6,620
            CDSs (with protein)               :: 6,620
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 3, 2 (16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 25 of 125
            Pseudo Genes (incomplete)         :: 107 of 125
            Pseudo Genes (internal stop)      :: 4 of 125
            Pseudo Genes (multiple problems)  :: 11 of 125
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 592552
            Orig. end                         :: 615342
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUT01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22790
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22790
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22790
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12790](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12790
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            310..495
                     /locus_tag="IE241_RS08040"
                     /old_locus_tag="GCM10010324_16480"
     CDS             310..495
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016472734.1"
                     /locus_tag="IE241_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16480"
                     /product="hypothetical protein"
                     /protein_id="WP_179080715.1"
                     /transl_table=11
                     /translation="MKRGEDLIQDLREQGFMRCETTSDGKAVVMRRRDRWTVVPLRWLT
                     DEAVDTIKAQAGVGLV"
     gene            565..1098
                     /locus_tag="IE241_RS08045"
                     /old_locus_tag="GCM10010324_16490"
     CDS             565..1098
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060275.1"
                     /locus_tag="IE241_RS08045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16490"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190020907.1"
                     /transl_table=11
                     /translation="MTGTTPLSVSWTIAPQPVGSAEAAALLREYLTDVADRWHLMHDGR
                     RCTPEEIDGYLAEDPSDSLDPPAGVLLVARRDGDPMGCVGLRWFDRERGTAELKRMYVR
                     PAARGNGLAPALLGAAEGLAREWGAERIVLDTRKDLVEAIRLYTRHGFTPVPRYNTVDE
                     NPYAEVWMGKELQA"
     gene            complement(1139..2035)
                     /locus_tag="IE241_RS08050"
                     /old_locus_tag="GCM10010324_16500"
     CDS             complement(1139..2035)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945144.1"
                     /locus_tag="IE241_RS08050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16500"
                     /product="ECF transporter S component"
                     /protein_id="WP_190020908.1"
                     /transl_table=11
                     /translation="MNDAAPDHKDTVPDRQDTVPDRKGLAPDRQARAIRLGRRSIAALL
                     LVSAVGVAAFGWPLLADSASGLAHSQDAPWLFAALLPLLLAVVVAAIADSGLDAKAVAM
                     LGVLAAAGAALRPLGAGTAGIEPMFFLMVLSGRVLGPGFGFVLGSVSMFASALLTGGVG
                     PWMPFQMLSMGWVAMGAGLLPGPDRLRGPREVLMLAGYGAAASLCYGTVMNLQGWPYIG
                     SLATGVSFVPGDPVQENLARFVAYCLATSLGWDVPRAIVTVTATLTLGPTVLKALRRAT
                     RRAAFDAPATFTEPPRR"
     gene            complement(2032..3735)
                     /locus_tag="IE241_RS08055"
                     /old_locus_tag="GCM10010324_16510"
     CDS             complement(2032..3735)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103395.1"
                     /locus_tag="IE241_RS08055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16510"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190020909.1"
                     /transl_table=11
                     /translation="MIRFDQVSVTYDDTEAPSLHEVDLTVPEGELCLLVGPSGVGKSTL
                     LGTVSGLVPHFTGGTLHGRVTVAGRDTRTHKPRELADVVGTVGQDPLAHFVTDTVEDEL
                     AYGMESLGIPPHTMRRRVEETLDLLGLATLRDRPIATLSGGQQQRVAIGSVLTTHPKVL
                     VLDEPTSALDPGAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADRVILLPGPGQAP
                     VMGEPAEVMAVSPVHPPVVDLGRLAGWSPVPLSVRDARRKAAPLRERLAPLAPQAAAAP
                     ADGEGLAARPRRRTGFLRKARRAAGPGPGPGPAAIAAAAAGLAVRHGRLVALRDVDLSV
                     RAGETVALMGRNGAGKSTLLRTLVGMHKPAAGSVRVGGVAPQSTSPAELLRHVGLVPQE
                     PRDLLYADTVAAECTAADGDAAAEPGTCRALVSRLLPDVAGTTHPRDLSEGQRLALALA
                     VVLTARPPLILLDEPTRGLDYAAKHRLVEILRGLAADGHAIVLATHDVELAAELAHRVV
                     VIADGEIVADGPTAEVVVSSPAFAPQVAKVLAPQPWLTVGQVRDALGAGS"
     gene            complement(<4326..5489)
                     /locus_tag="IE241_RS08060"
                     /old_locus_tag="GCM10010324_16520"
                     /pseudo=""
     CDS             complement(<4326..5489)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892284.1"
                     /locus_tag="IE241_RS08060"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16520"
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNDRKKPLRGGVGADSGTGAETGGGGGGGGGGAPLTSRASALHAG
                     AWWVWALGLAAAASRTTNVLLLGLLIAVAGYVVAARRTDAPWARSYGAFLKLGLVVIGI
                     RLVFAIVLGSPIPGTHTLFTLPEVPLPDWARGVRLGGRVTAEGMLFAFADGMKLATLLV
                     CVGAANALASPARLLKSLPGALYEAGVAVVVAMTFAPNLVADVQRLRAARRLRGRPDRG
                     FAALLQVGLPVLEGALERSVALAASMDARGYGRTARVPRSVRRTTSVLTLGGLMGVCAG
                     TYGLLADQGAGYGMPVLLAGLAAALAGLWLGGRRSVRTRYRPDRWGVRAWLVSGSGVAV
                     AALMIRAGSYAPGALHPQAVPLTVPQLPLWPAAAVLIGLLPAFVAPAP"
     gene            complement(5486..6178)
                     /locus_tag="IE241_RS08065"
                     /old_locus_tag="GCM10010324_16530"
     CDS             complement(5486..6178)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093333.1"
                     /locus_tag="IE241_RS08065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16530"
                     /product="SCO2322 family protein"
                     /protein_id="WP_190021094.1"
                     /transl_table=11
                     /translation="MRGGAVAAPTAVLLALITLLTFLGTAPAHAAGYRYWSFWQGSGGQ
                     WAYATQGPATARPGDGEAVGFRFAVSADSSDAAKPRAAAGFGAVCDRTPAKDGTKRVAV
                     VLDFGTAADAPEGETPPAARSACAQVGEDATAGEALAAVAKPLRYDSSALLCAIAGYPR
                     TGCGEQVGGGKKSSQGAGSAQPSPAGSDAAGGGDSGDGGPSAGLIGGVAAVVVLGAAAF
                     WQARRRRG"
     gene            complement(6208..7485)
                     /locus_tag="IE241_RS08070"
                     /old_locus_tag="GCM10010324_16540"
     CDS             complement(6208..7485)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989881.1"
                     /locus_tag="IE241_RS08070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16540"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_190020910.1"
                     /transl_table=11
                     /translation="MAPSLVVHARRGAAVLATAAALSTAVAPAAFADGSPSPAAPGLYG
                     TADPKFDGVFRQSLAFMAQSAVSVSPAKQAVDWLAGQQCADGGFPGYRADTGKACDPKK
                     DEFTDATAAAVQGLAAAGGRSDAVKKGLDWLKAHQNDDGGWGYQAGSPSDANSTSIALG
                     AFAAAGQDPAKEAAKGGKNPAETLLTFQLGCDAKEEGERGAFAYLKDDKGLRADNLASA
                     AAALATRGKGYLVEPLKKDADRPVKPLECSGDNQAKPKDAAASAEAVDGYLVAAMDKNG
                     GYLLPSMPGAPAKPDQGNTADAALALAAGGHRAAAEKPLKWLQSKESGTAEWAKGQPGR
                     LAKLILATDAAGGNPHDFAGTDLVEQLNATGPAPEKKATGGMDKKDEEKDDDSVTINVW
                     WIVGVGLAFGAGIGFLISGRKKKQQL"
     regulatory      complement(7671..7813)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    7790..7802
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    7796..7813
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.25"
                     /tool="antismash"
     misc_feature    complement(7947..7961)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.36"
                     /tool="antismash"
     gene            8116..9594
                     /locus_tag="IE241_RS08075"
                     /old_locus_tag="GCM10010324_16560"
     CDS             8116..9594
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239052.1"
                     /locus_tag="IE241_RS08075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16560"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_229898960.1"
                     /sec_met_domain="Aldedh (E-value: 1.7e-154, bitscore:
                     510.1, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDPAGRAVIDVVSPHTEEVIGRVPHASREDVDRAVAAARTSFDS
                     GIWADRPPAERIEVVTRIKDGIAARHEELARTVSAQNGSPYSWSVLAQALGAMMVWDCA
                     IAVARELSYEERRAGALGPLLVRREPVGVVAAVVPWNVPQLVAAAKLAPALLTGCSVVL
                     KPSPETPLDSYLLAEIVTEAGLPEGVLSILPAEREVSEYLVGHPGVDKVAFTGSVAAGK
                     RVMEVAARHLTRVTLELGGKSAAIILPDADPEEAVAGIVPSAWMNNGQACVAQTRILAP
                     RAHYAELAERFAAAASALVVGDPLDPATQVGPLVAERQRRRSLEYIALGQREGAKVLAG
                     GGRPADRDTGWYVEPTLFGDVTNDMRIAREEIFGPVICLLPYDTEEEAVRIADDSDYGL
                     SGSVWTRDAERGIEVARRVRTGTYSVNTFALDMFGPFGGYKNSGLGREFGPEGFAEYLE
                     HKTIHLPAGHGEVPGAPEAPEAPGAPGEHAGGEV"
     gene            9600..9857
                     /locus_tag="IE241_RS08080"
                     /old_locus_tag="GCM10010324_16570"
     CDS             9600..9857
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957280.1"
                     /locus_tag="IE241_RS08080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16570"
                     /product="ferredoxin"
                     /protein_id="WP_190020912.1"
                     /transl_table=11
                     /translation="MSGRWRVQVDQGLCVGSGMCVGSAPEAFALDAGRRSRPVAEEIAE
                     EVAEETDASGPVLAAAESCPVEAITISVLDTGEPVFPPDE"
     misc_feature    9899..9916
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            10001..12790
                     /gene="lanKC"
                     /locus_tag="IE241_RS08085"
                     /old_locus_tag="GCM10010324_16580"
     CDS             10001..12790
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983511.1"
                     /locus_tag="IE241_RS08085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16580"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_190020913.1"
                     /sec_met_domain="micKC (E-value: 1.3e-230, bitscore: 763.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.7e-09, bitscore: 32.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-11, bitscore:
                     38.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDARYEVYCLADRHFYETPDRLSVPGAGGEGAREAGLYETARRPA
                     PGGWSTSRHGDWLHVFPAGEDGGPRPGQPLQGWKIHVSATADTADKTAADVWDYCVARD
                     IPFKFVPGPHLLHLRNNKYAERGHSGKFVTIYPSGEEQLHSTLAGLHEILGGRPGPYIL
                     TDLRWHEGPLYVRYGAFARRFCIDGRGTLVPAVEDGDGKLVPDSRNPAFQVPSWVTLPA
                     FLAPHLAARNATTVGDLPYRIEKALHFSNGGGVYAGTDTRDGRKVVLKEGRPHAGLAAD
                     GADAVARLEREKDALERLAGLGVAPEARDWLTIGDHRFLVMDFVEGKPLNSFFAHRHPL
                     LAADPEPTATADYTAWALRIHRAVEEAVEKVHARGVVFNDLHMFNIMVAPDEDSVVLID
                     FEAAAPESEHGRQVVAHPGFFAPPDRRGADVDRYALACLRLALFLPITTLFVIDRAKAA
                     HLADVIAEQFPVPREFLDEAVAEITRGTEPAEAAEPVEAEEAVREAAEPAPSAASGPPG
                     RRTRTLAPGAGHALPLHDLPDPAEDWPGARASMVRALLASATPGRDDRLFPGDIAQFSE
                     GGGLGLAHGAAGVLHALAEAGAERYEEGEQWLLRHTDPVPSGTPLGLYDGLAGVACTLD
                     RLGHTRRALELSGLMLGEQWQRLTSDLRSGLAGVGLALDHLARTTGERQLHDQAVEAAQ
                     LLADRLAADSSGQGEDGSGPRRRAGLMRGASGPALLFLRLYERTGAPALLDLAEQALRT
                     DLARCTRTAGGTLEVDEGWRTMPYLGDGSAGIGMVLDDFLAHHPDPDPYFTDARDGILT
                     AARSRFYAQPGLFQGRAGMILHLARTTAPGATPGHLAAQVRGLSWYAMSYQGELAYPGS
                     QMMRLSMDLATGTAGCLLALAAALDDDGARPAGAAPAQLPFLPPLRGPRSRLHAVVEP"
     gene            12907..13029
                     /locus_tag="IE241_RS08090"
                     /old_locus_tag="GCM10010324_16590"
     CDS             12907..13029
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983510.1"
                     /locus_tag="IE241_RS08090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16590"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_190020914.1"
                     /transl_table=11
                     /translation="MALLDLQNMESDENTGHGGGGQSTVSLLSCVSTASVLICL"
     CDS_motif       12907..12966
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQNMESDENTGHGGG"
                     /locus_tag="IE241_RS08090_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12967..13029
                     /prepeptide="core"
                     /locus_tag="IE241_RS08090_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="13.90"
                     /molecular_weight="1855.2"
                     /monoisotopic_mass="1854.0"
                     /core_sequence="GQSTVSLLSCVSTASVLICL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQNMESDENTGHGGG"
                     /leader_location="[12906:12966](+)"
                     /alternative_weights="1873.2"
                     /alternative_weights="1891.2"
                     /alternative_weights="1909.3"
                     /alternative_weights="1927.3"
                     /alternative_weights="1945.3"
     misc_feature    12914..12928
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            13182..14885
                     /locus_tag="IE241_RS08095"
                     /old_locus_tag="GCM10010324_16600"
     CDS             13182..14885
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134772.1"
                     /locus_tag="IE241_RS08095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190020915.1"
                     /transl_table=11
                     /translation="MAHTRTATASTGDRLLLGTARHSAARAAALALLAVASTGAALLLP
                     VTLGHTLDLLLARRGADTGRWVGLCALLVAGPAALDALAELLTGTTAAHATARLRHRLL
                     GHVLATGPQATGRFPPGDLVTRLVGNAADTGTAPATLAHAAASVAGPVGGIVALGLIDP
                     RLALAFLAGAPLLAVLLRAFTRASTDCVARYQQLQGDIAGRLVEALGGARTIAAAGTTA
                     REEARILGPLPGLSREGHRMWRVQGRSTAQAGTLVPLLQITVLAVAGLRLSQGLLSVGD
                     LLAASRYAVLATGVGMLVGHLNAAARARAAAARAAEVLAVPAAPYGERLLPPGPGTLEL
                     RGVRAARGGRTVLQDVTVTVPGGSSLAVVGRSGSGKSVLAEVAGRLADPDAGTVLLDGV
                     PLSALRHHDLRRAVGYAFARPALLGGTVGGTIGFGAVTPGREVREAAARAACADDFVRR
                     LPHGYDTPCADAPLSGGEAQRLGLARAFAHAGRLLILDDATSSLDTATERRVTAALHAS
                     SAPTRVLIAHRVTTAASTDRVLWLHEGRVRAVAPHAELWDDPDYRAVFDA"
     gene            complement(15323..15520)
                     /locus_tag="IE241_RS08100"
                     /old_locus_tag="GCM10010324_16610"
     CDS             complement(15323..15520)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE241_RS08100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010324_16610"
                     /product="hypothetical protein"
                     /protein_id="WP_190021112.1"
                     /transl_table=11
                     /translation="MRSARQGRFGSPPRRKERADAPAAGRLGRSVRSAPPDSTVERLAV
                     AAEEGGCGPAAFGSPSGIAG"
     misc_feature    complement(15678..15692)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            16403..>16987
                     /locus_tag="IE241_RS34925"
                     /pseudo=""
     CDS             16403..>16987
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="IE241_RS34925"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPALQNLVHGLGTSGSRLAVVVRRLTAPGLPDGPPGEPAATATAA
                     PQDAPAPALALRRLTFAYGDRADPVVRDLDLTLPRGAHLAVVGPSGVGKSTLAGLVAGL
                     LRPGGGEVTVGGARAGTAAAAARRVLIPQEAYVFSGTVADNLGYLRDDPVPEEELRAAA
                     EALGMAELVRRVGGFAAPLAPAELSAGERQQI"
     gene            complement(17324..17935)
                     /locus_tag="IE241_RS34765"
     CDS             complement(17324..17935)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142169.1"
                     /locus_tag="IE241_RS34765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA-binding response regulator"
                     /protein_id="WP_373300620.1"
                     /transl_table=11
                     /translation="MIRVLLVHDTYLLRAALAALLGREPDLEVSSASWQRAVVMSDSLR
                     PHVCVVDMDSPEAGGPGGLRELSGHGDARDDRAALLALASAGRPGPLRRAYEEKALGYL
                     SKNASPDRLVEGIRHVAKGERYIDETLGFGFLEAAEIPLTRRELSVLSLAAEGASVGEI
                     ASSLHLSNGTVRNYMAAITRKTGARNRVDAIRISQGAGWV"
     gene            complement(18128..18766)
                     /locus_tag="IE241_RS08115"
                     /old_locus_tag="GCM10010324_16630"
     CDS             complement(18128..18766)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093328.1"
                     /locus_tag="IE241_RS08115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16630"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_190020917.1"
                     /transl_table=11
                     /translation="MTTEPKSPTARAVPAGPSLPLTERQEARRRRILQATAELASRGGF
                     DAVQMREVAEAAGVALGTLYRYFPSKIHLLVATMQDQLQRLHGTLRKRPPTDADPAARV
                     AQTLMRAFRAMQREPHLADAMVRALTFADRSVSSEVDTVSRLTTTIILDAMGPAGPPTP
                     EQLSAVRVIEHTWHSALITWLSGRASIAQVRIDIETVCRLIRLTTPQQA"
     misc_feature    complement(18918..18931)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            18989..20368
                     /locus_tag="IE241_RS08120"
                     /old_locus_tag="GCM10010324_16640"
     CDS             18989..20368
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010637585.1"
                     /locus_tag="IE241_RS08120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16640"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_373300607.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 9.7e-30,
                     bitscore: 98.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEATEAALADAAAREARAGQDARNDGLRDGDGDRPLRIALLTY
                     KGNPFCGGQGVYVRHLSRELARLGHSVEVIGSQPYPVLDEGVTLTELPSLDLYRQPDPF
                     RTPGRDEYRDWIDALEVSTMWTGGFPEPLTFSLRARRHLAAQRGRFDVVHDNQTLGYGL
                     LGGPAAIGAPLVTTVHHPITVDRQLDLAAAADWKRRASVRRWYGFTRMQKRVARRLPSV
                     LTVSGSSRQEIVDHLGVRAERVHVVPIGADTDLFSPDPSVPEVPGRIVTTSSADVPLKG
                     LVHLIEALAVVRRRHPAAHLVVVGKRAEDGPVATAIRRCGLENAVEFVKGITDAELVDL
                     VRSAQVACVPSLYEGFSLPAAEAMATGTPLAATTGGAIPEVAGPDGETCLAVPPGDPGA
                     LASALGRLLDDPGLRRRLGAAGRERVLSRFTWREAAIGTARHYREAIALAGGARSAGRP
                     A"
     gene            20928..21665
                     /locus_tag="IE241_RS08125"
                     /old_locus_tag="GCM10010324_16650"
     CDS             20928..21665
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718380.1"
                     /locus_tag="IE241_RS08125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16650"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_190020918.1"
                     /transl_table=11
                     /translation="MLTVDFSRFPLAAGDRVLDLGCGAGRHAFECYRRGARVVALDRNG
                     EEIREVAKWFAAMKEAGEAPPGATATAMEGDALALPFPDDSFDVVIISEVMEHIPDDKG
                     VLAEMVRVLKPGGRIAVTVPRYGPEKICWALSDAYHEVEGGHIRIYRGDELLDRMREAG
                     LVPYGTHHAHGLHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPLATRVAEQALN
                     PLIGKSFVAYATKPHLPATGTDA"
     misc_feature    20932..20946
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     gene            21662..22744
                     /locus_tag="IE241_RS08130"
                     /old_locus_tag="GCM10010324_16660"
     CDS             21662..22744
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953108.1"
                     /locus_tag="IE241_RS08130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010324_16660"
                     /product="prenyltransferase"
                     /protein_id="WP_190020919.1"
                     /transl_table=11
                     /translation="MTLFSRGSGRTERLVLPGVLTAEQVTGTVAGIAAVQREDGAIPWF
                     RGHHLDPWDHTEAAMALDAAGEHDRAEAAYRWLARHQNSDGSWYAAYADGAADEPTDRS
                     RESNFVAYVAVGVWHHYLATGDDAFLDSMWPTVYAAVEFVLALQQAGGQIGWKREEDGT
                     PVTDALLTGSSSIHQALRCALAIAEHREEPQPDWELATGLLAHAIRRHPERFLDKSRYS
                     MDWYYPVLGGAVTGVAAKERIEEGWDRFVVPGLGVRCVLPNPWVTGGESCELALALWVM
                     GESDRAVQILQWIQHLRAADGMYWTGYVYDDDAVWPEERTTWTAGSLLLAAAALGGDEA
                     TTAVFGGERLPAGLEPDCCA"
ORIGIN
        1 ggtgatcggg caccggggtt cgcgtgtgca ggtgcgtacg cccggtggcg ggctcgaatg
       61 ggaggtgtcc acgtccgcgc tgcggctggc catgggccag gagcgggagg cgttccgggc
      121 gctggccaac agtgacggca cgcactggtc gggttgcggc agatgctccg agctggatgg
      181 ggcctggcgt gcggcatccg cagccgggga gcgcacgaac gaggccgtcg atgccctgag
      241 caggtttcgt aaccactggc ggctggacca cgccgtatca gcggctgacg acaaggaccg
      301 ggacgggtga tgaagcgggg cgaggatctg atccaggacc tgcgagagca gggcttcatg
      361 cggtgcgaga ccacctcgga cggtaaagcc gtggtcatgc gcaggcgcga ccggtggacc
      421 gtggttcccc tgcgatggct cactgatgaa gccgtggaca ccatcaaggc ccaagcaggc
      481 gtcggcctcg tctgagcgcg gggtggggcc ggggcctcca taattcgggc gcgcgcccgg
      541 aattccccgt gcgaccatgc cgccatgacc ggcaccaccc cgctctccgt gtcctggacc
      601 atcgccccgc agcccgtcgg ctccgccgag gccgctgcgt tgctgcgcga gtacctgacg
      661 gacgtcgccg accggtggca cctgatgcac gacggccgcc gctgtacgcc cgaagagatc
      721 gacggttacc tcgccgagga cccgagcgac tctctcgacc cgcccgcggg cgtgctgctc
      781 gtcgcccggc gggacgggga cccgatgggg tgtgtggggc tgcggtggtt cgaccgggag
      841 cgggggaccg ccgagttgaa gcggatgtac gtgcggcccg ccgcgcgggg gaacgggctt
      901 gcgcccgcgc tgctgggcgc ggccgagggt cttgcccggg agtggggcgc ggagcggatc
      961 gtcctggata cgcggaagga ccttgtggag gccatcaggc tgtacacgag gcacggattc
     1021 acccccgtac cccggtacaa caccgttgac gagaacccgt acgccgaggt gtggatgggc
     1081 aaggagctgc aggcctgagt cgctgcaggc ctgaccggct cagcggcggg gcggctcgtc
     1141 agcggcgggg cggctcggtg aatgtcgccg gggcgtcgaa cgccgccctc cgcgtcgccc
     1201 gccgcagcgc cttcaggacc gtcgggccga gcgtgagggt cgcggtgacg gtcacgatcg
     1261 cgcgcggcac gtcccagccc agggacgtcg ccagacagta cgcgacgaag cgggcgaggt
     1321 tctcctggac ggggtcgccg gggacgaagg agactcccgt ggcgagcgag ccgatgtagg
     1381 gccagccctg gaggttcatc accgtgccgt agcagaggga cgccgccgcg ccgtagcccg
     1441 cgagcatcag cacctcgcgg gggccgcgca ggcggtcggg gccgggcagc agacccgcgc
     1501 ccatggccac ccaccccatc gacagcatct ggaacggcat ccagggcccg acgccgcccg
     1561 tcagcagcgc cgacgcgaac atcgacaccg agccgagcac gaagccgaag ccggggccga
     1621 ggacgcggcc cgacagcacc atcaggaaga acatcggctc gatgccggcc gtccccgcgc
     1681 ccagcgggcg cagggccgcg cccgccgccg ccaggacgcc gagcatcgcg acggccttcg
     1741 cgtccaggcc cgagtcggcg atggccgcca ccacgacggc cagcagcagc ggcagcagcg
     1801 ccgcgaacag ccacggggcg tcctgggagt gcgcgagccc cgacgcggag tcggcgagca
     1861 ggggccagcc gaacgccgcc accccgaccg cggagacgag gagcagggcg gcgatcgagc
     1921 gtctgccgag gcggatcgcc cgcgcctggc ggtcgggggc gaggcccttg cggtcgggga
     1981 cggtgtcctg acggtcgggg acggtgtcct tgtggtcggg tgcggcgtcg ttcatgaccc
     2041 cgcccccagc gcgtcccgca cctgtcccac cgtcagccac ggctgtggcg cgagcacctt
     2101 ggcgacctgt ggtgcgaagg ccggcgagga gaccaccacc tcggccgtcg ggccgtccgc
     2161 gacgatctcg ccgtcggcga tgacgacgac ccggtgggcc agctccgcgg ccagttccac
     2221 gtcgtgcgtc gccaggacga tcgcgtgccc gtcggcggcg aggccgcgca ggatctccac
     2281 caggcggtgc ttggccgcgt agtcgaggcc gcgggtcggc tcgtcgagga ggatcagcgg
     2341 cgggcgcgcc gtcagcacga ccgcgagggc gagcgcgaga cgctggccct ccgacaggtc
     2401 gcgcgggtgc gtcgtaccgg cgacgtccgg gaggagccgg gagacgagcg cgcggcaggt
     2461 gcccggttcc gcggccgcgt cgccgtcggc cgccgtgcac tcggccgcga ccgtgtccgc
     2521 gtacagcagg tcgcgcggct cttgtggtac gaggcccacg tggcgcagca gttccgccgg
     2581 ggacgtgctc tgcggggcga cgccgcccac gcgtacggag cccgcggcgg gcttgtgcat
     2641 gccgacgagc gtacgcagca gcgtggactt gcccgccccg ttgcggccca tcagggcgac
     2701 cgtctccccg gcccgtacgg acaggtccac gtcgcgcagc gccaccagcc ggccgtgccg
     2761 gacggcgagc ccggcggcgg ccgctgcgat cgcggcgggg ccgggaccgg ggccgggacc
     2821 cgccgcgcgg cgggccttgc gcaggaagcc ggtacggcgg cgggggcggg ccgcgaggcc
     2881 ttccccgtcc gccggggcgg ccgcggcctg cggcgccagc ggggccagcc gctcccgcag
     2941 cggtgccgcc ttgcggcgcg cgtcccgtac ggacaggggg accggcgacc agccggccag
     3001 gcggccgagg tcgaccaccg gcgggtggac gggcgatacg gccatgacct cggccggctc
     3061 tcccatgacg ggggcctgcc cggggcccgg cagcaggatg acgcggtccg cgtactgcac
     3121 gacccgctcc agccggtgct ccgccatcag cacggtggtg cccaggtcgt ggaccaggcg
     3181 ctgcaggacg gcgagcacct cctcggccgc gcccgggtcg agggcggacg tcggctcgtc
     3241 gaggaccagc accttcgggt gggtggtcag caccgagccg atcgcgacgc gctgctgctg
     3301 gccgccggag agcgtggcga tggggcggtc gcggagggtc gcgaggccca gcaggtccag
     3361 ggtctcctcg acgcggcgcc gcatggtgtg cggggggatg ccgagggact ccatgccgta
     3421 ggcgagctcg tcctcgacgg tgtcggtgac gaagtgcgcg agcgggtcct ggcccacggt
     3481 gccgacgacg tcggccagtt cgcgcggctt gtgggtacgg gtgtcgcggc cggcgacggt
     3541 gacgcggccg tgcagggtgc cgccggtgaa gtgcgggacg aggccgctga cggtgccgag
     3601 gagggtggac ttgccgacgc cggaggggcc gacgaggagg cagagctcgc cctcggggac
     3661 ggtgaggtcc acttcgtgga gcgagggtgc ctcggtgtcg tcgtaggtga ccgacacctg
     3721 atcgaagcgg atcacttggg ctcctcgggg tggggcatgc gggtcgtttc ggcaccgccg
     3781 ggctccccgg cgggggctga gcgccgtcgc ggcggagagg gatgccccgg tcccaccctt
     3841 tcaccgtttc ccggggctgt gccccggacc tcggggggtg gggtggtgga ggctgtgccc
     3901 cggacctcgg ggggtggggt ggtggaggct gcgccccggg ccccgggggg tggggtggtg
     3961 gaggctgtgc cccgggcccc ggggggtggg gtggtggagg ctgtgccccg ggccccgggc
     4021 cgtgggctgg aggccccgtc cccggccccg ggcccgggcc gtggggcggc ggctgcgccc
     4081 cgggcccccg gcggggtggc ggacgcttcg ccccggctcc cgggaagtcg ggggcccgcc
     4141 cccggatccg ggaaggggcg ggaccgggga agatctcccg ccgcagcggt gctccgcccc
     4201 caccggcctg ttcggcggtg cccggcagcc tccggctcgg ctgccccccg ctcggcaggg
     4261 cccgtcccgg cgcctcgctg cgcgcgcccc ggcccggcgg tcgcatcccg cgagcccccg
     4321 ccggaaggcg ccggcgccac gaacgccggc agcaggccga tcaggaccgc cgccgccggc
     4381 cacagcggca gctgcggcac cgtcaggggg accgcctgcg ggtgcagtgc gccgggcgcg
     4441 taggagcccg cccggatcat cagggccgcg accgccacgc ccgagcccga caccagccac
     4501 gctcgtacgc cccaccggtc cggccggtag cgcgtgcgga ccgagcggcg gccgcccagc
     4561 cacaggcccg ccagcgcggc ggcgaggccg gccagcagga cgggcatccc gtagcccgcg
     4621 ccctggtcgg cgagcagccc gtacgtgccg gcgcagacgc ccatcaggcc gcccagcgtc
     4681 agcacgctcg tggtgcggcg gacggagcgc ggcacccggg ccgtacggcc gtagccccgt
     4741 gcgtccatcg acgccgccag cgccacggat cgctccagcg cgccctccag caccggcagc
     4801 cccacctgga gcagggcggc gaagccgcgg tcagggcgcc cgcgcaggcg gcgggcggcg
     4861 cgcagccgct ggacgtcggc gacgaggttc ggcgcgaacg tcatggcgac gacgaccgcg
     4921 acgcccgcct cgtacagcgc ccccggcagg gacttcagca gccgcgccgg gctggcgagc
     4981 gcgttggccg cgcccacgca caccagcagc gtggccagct tcatgccgtc ggcgaacgcg
     5041 aagagcattc cctcggccgt cacccggccg ccgagccgca ccccccgcgc ccagtccggg
     5101 agcggcacct ccggcagggt gaagagcgtg tgcgtgcccg ggatcgggga gcccagcacg
     5161 atcgcgaaga ccagccggat gccgatgacg acgaggccga gcttgaggaa agccccgtac
     5221 gagcgtgccc acggcgcgtc cgtgcgccgc gcggccacga cgtagccggc gacggcgatc
     5281 agcaggccga gcagcaggac gttggtggtg cgggaggcgg ccgcggccag accgagcgcc
     5341 cacacccacc aggcgcccgc gtgcagcgcg gaggcgcgcg aggtcagcgg cgcgcctcct
     5401 ccgccgccgc ccccgccgcc cccggtctcg gctccggtgc cgctgtcggc accgaccccg
     5461 ccccgcagcg gcttcttcct gtcgttcatc cgcggcgtcg gcgggcctgc cagaaggccg
     5521 cggcaccgag gacgaccacg gcggcgacgc cgccgatcag gccggccgac gggccgccgt
     5581 cgccggagtc cccgcccccg gcggcgtcgc tcccggccgg gctcggctgt gcgctccccg
     5641 cgccctggga actcttcttc ccgccgccga cctgctcgcc gcagcccgtc cgcgggtagc
     5701 cggcgatggc gcacagcagt gcggaggagt cgtagcgcag cggcttggcg acggcggcca
     5761 gggcctcgcc cgccgtcgcg tcctcgccca cctgggcgca ggcggagcgg gccgcgggcg
     5821 gcgtctcgcc ctcgggggcg tccgcggccg tgccgaagtc gaggacgacg gcgacgcgct
     5881 tcgtgccgtc cttggcgggc gtacggtcgc agaccgcccc gaagccggcg gcggcacgcg
     5941 gcttcgcggc gtcggaggag tccgcgctga cggcgaaccg gaacccgacg gcctccccgt
     6001 cgccgggccg cgccgtggcc ggcccctgcg tggcgtacgc ccactgcccg ccggagccct
     6061 gccagaacga ccagtaccgg tacccggcgg cgtgcgccgg ggcagtgccg aggaaggtga
     6121 ggagggtgat gagggcgagg agtacggcgg tgggcgcggc gacggcgccg ccgcgcatcc
     6181 cggcagctcg catcccggca gctcgcgtca cagctgctgc ttcttcttgc ggccgctgat
     6241 caggaagccg atgccggcac cgaaggccag gccgacgccg acgatccacc acacgttgat
     6301 cgtgacggag tcgtcgtcct tctcctcgtc cttcttgtcc atgccgccgg tggccttctt
     6361 ctccggggcc gggccggtgg cgttcagctg ctccaccagg tcggtgcccg cgaagtcgtg
     6421 cgggttgccg cccgccgcgt cggtggccag gatcagcttg gcgagccggc cgggctggcc
     6481 cttggcccac tcggcggtgc cgctctcctt ggactgcagc cacttcaggg gcttctcggc
     6541 ggcggcgcgg tggcctcccg cggcgagggc gagggcggcg tcggccgtgt tgccctggtc
     6601 gggcttggcg ggggcgccgg gcatggacgg cagcaggtag ccgccgttct tgtccatggc
     6661 ggccacgagg tagccgtcca cggcctcggc ggacgcggcg gcgtccttgg gcttcgcctg
     6721 gttgtcgccg gagcactcca gcggcttgac cggccggtcg gcgtccttct tcaggggctc
     6781 gacgaggtag cccttgccgc gcgtggcgag cgcggcggcg gcgctggcga ggttgtcggc
     6841 gcgcagcccc ttgtcgtcct tgaggtacgc gaacgcgccg cgctcgccct cctccttggc
     6901 gtcgcagccg agctggaagg tcagcagcgt ctcggcgggg ttcttgccgc ccttggcggc
     6961 ctccttggcc gggtcctggc cggccgccgc gaacgcgccg agggcgatgg aggtggagtt
     7021 ggcgtcgctg gggctgcccg cctggtagcc ccagccgccg tcgtcgttct ggtgggcctt
     7081 gagccagtcg aggcccttct tgacggcgtc cgagcggccg ccggcggcgg cgaggccctg
     7141 cacggccgcg gcggtggcgt ccgtgaactc gtccttcttg gggtcgcacg ccttgccggt
     7201 gtcggcgcgg tagccgggga agccgccgtc cgcgcactgc tggccggcga gccagtcgac
     7261 ggcctgcttg gccgggctga cgctcaccgc gctctgcgcc atgaaggcca gggactgccg
     7321 gaagacgccg tcgaacttgg ggtccgccgt gccgtagagc cccggggcgg ccggggacgg
     7381 ggagccgtcg gcgaaggcgg cgggggccac ggccgtgctc agggcggcgg cggtggccag
     7441 gaccgcggcg ccgcggcgcg cgtggacgac gagggagggg gccatggggt cgtgcctctc
     7501 gggtgggtgt cactgcggtg gccggcatgc cggggtacgc ggtcgcgcag ccgcgcacgg
     7561 ccgccgcccc gcgagctccg tcggctccgc gcggtggcac cgggctcggc tccgcatacc
     7621 tcgacggtgc cggtggaccg ggcggcaccg ccatgcggta cgaccggctc cggaagcctg
     7681 ccgcctggcc cgggtggtcc ggctcgtacg gcggcgccgg gcggcgggcc gtagtcacgg
     7741 ttgcgggtca gcgccggatt tgcaccggct tcccccgttc cgaggcggga tgaagttgtc
     7801 acggacactt taaccggccg ggtcggggcc gggtcggggt ccggtcgtgc ggctcggtcg
     7861 tgcggctcgg ttgtgtggcc cggtcgtgcg gcccggtcgt gcggcgagcc cgccgacccc
     7921 gttgccccgg cgccggagga gctgctaact gtctgataca gcgtcagatc cgacgctcgc
     7981 ggctcgctcc gcagacgcgc gggaggcatc gacatgaacc gggatgcgaa tcggcatacg
     8041 aaccaggaca agaatgggct gaaccggaac aagaacggac tgatcgagca cgggcagctc
     8101 ttcatcggcg gcaccatgac cgacccggcc ggccgcgccg tcatcgacgt cgtgtcgccg
     8161 cacaccgagg aggtcatcgg ccgcgtcccg cacgcctcgc gcgaggacgt cgaccgcgcc
     8221 gtggccgcgg cccgcacctc cttcgactcc ggcatctggg ccgaccggcc accggccgag
     8281 cgcatcgagg tcgtcacgcg gatcaaggac ggcatcgccg cccggcacga ggagctggcc
     8341 cgcaccgtct ccgcccagaa cggctccccg tactcctgga gcgtgctcgc gcaggccctc
     8401 ggcgcgatga tggtgtggga ctgcgccatc gccgtcgccc gcgagctgtc ctacgaggag
     8461 cggcgggcgg gcgccctcgg gccgctgctg gtgcggcgcg agcccgtcgg cgtcgtcgcg
     8521 gccgtcgtgc cgtggaacgt cccgcagctg gtggccgcgg cgaagctcgc gcccgcgctg
     8581 ctgaccggct gctcggtggt gctcaagccc tcgcccgaga cgcccctgga ctcctacctg
     8641 ctggcggaga tcgtcaccga ggcgggcctg ccggagggcg tgctgtcgat cctgcccgcg
     8701 gagcgggagg tcagcgagta cctcgtcggc cacccgggcg tcgacaaggt ggccttcacc
     8761 ggctcggtcg cggcgggcaa gcgcgtcatg gaggtcgccg cacgccacct cacccgcgtc
     8821 accctggagc tcggcgggaa gtccgcggcg atcatcctgc ccgacgccga cccggaggag
     8881 gccgtcgccg gcatcgtccc cagcgcctgg atgaacaacg ggcaggcgtg cgtcgcccag
     8941 acgcgcatcc tcgcgccccg cgcccactac gccgagctgg ccgagcgctt cgccgcggcc
     9001 gcctccgccc tcgtcgtcgg cgaccccctc gaccccgcca cccaggtcgg cccgctcgtc
     9061 gccgaacggc agcggcggcg ctccctggag tacatcgcgc tcgggcagcg cgagggcgcc
     9121 aaggtgctcg ccggaggcgg gcggccggcg gaccgcgaca ccggctggta cgtggagccc
     9181 accctcttcg gcgacgtcac caacgacatg cggatcgccc gcgaggagat cttcggcccc
     9241 gtgatctgcc tgctgcccta cgacacggag gaggaggccg tgcgcatcgc cgacgactcc
     9301 gactacgggc tctccggcag cgtctggacc cgcgacgccg aacgcggcat cgaggtcgcc
     9361 cgccgggtgc gcaccggcac gtactcggtg aacaccttcg ccctcgacat gttcggcccc
     9421 ttcggcggct acaagaactc cggcctgggg cgggagttcg ggcccgaggg cttcgccgaa
     9481 tacctggagc acaagacgat ccacctgccg gcggggcacg gggaggtgcc cggggcgccc
     9541 gaggcgcctg aggcacccgg ggcgcccggg gagcacgccg ggggagaggt gtgactgcgg
     9601 tgagcgggcg ctggcgcgtg caggtcgacc aggggctgtg cgtgggctcg gggatgtgcg
     9661 tggggagcgc gccggaggcc ttcgcgctcg acgccggccg gcgctcgcgc ccggtcgcgg
     9721 aggagatcgc ggaggaggtc gccgaggaga cggacgcatc cggtccggtg ctcgcggccg
     9781 ccgagagctg cccggtggag gcgatcacga tcagcgtcct ggacacggga gagcccgtct
     9841 tccctccgga cgagtgaagc gggcgcgtgt gcagcaacgc ccttcgtacg catgcgcgtt
     9901 gttactcatg cgttccgcac gcttccttga tgacacatgt gactggccgg gcccctcacg
     9961 gcgtggaaat ctctaggcaa caaagccgag gggggcgacg atggacgcgc ggtacgaggt
    10021 ctactgcctg gccgacaggc atttctacga gaccccggac cgcctgtccg tcccgggggc
    10081 gggcggcgag ggagcccggg aggcgggcct gtacgagacc gcccgccgcc ctgcccccgg
    10141 cggctggagc acctcccgcc acggcgactg gctccatgtc ttccccgccg gggaggacgg
    10201 cggcccgcgc cccgggcagc ccctccaggg ctggaagatc cacgtctccg ccaccgccga
    10261 caccgcggac aagaccgccg ccgacgtctg ggactactgc gtcgcccggg acatcccgtt
    10321 caagttcgtc cccggcccgc acctgctgca cctgcgcaac aacaaatacg cggagcgcgg
    10381 ccacagcggg aagttcgtca ccatctatcc gtccggtgag gagcagctgc actccaccct
    10441 ggccgggctg cacgagatcc tcggcggccg ccccggcccg tacatcctca ccgacctgcg
    10501 ctggcacgaa ggcccgctct acgtgcgcta cggcgccttc gcccgccgct tctgcatcga
    10561 cggccgcggc accctcgtgc ccgccgtcga ggacggcgac ggcaagctcg tccccgactc
    10621 ccgcaacccg gccttccagg tcccctcgtg ggtgacgctg cccgccttcc tcgccccgca
    10681 cctcgccgcg cgcaacgcca ccaccgtcgg cgacctgccc taccgcatcg agaaggccct
    10741 gcacttctcg aacggcggcg gcgtctacgc cggtaccgac acgcgcgacg gccgcaaggt
    10801 cgtcctcaag gaaggccgcc cgcacgccgg gctcgccgcc gacggggccg acgccgtggc
    10861 ccggctggag cgcgagaagg acgccctgga gcggctcgcc ggcctcggtg tcgcccccga
    10921 ggcgcgggac tggctgacca tcggcgacca ccgcttcctc gtcatggact tcgtcgaggg
    10981 aaagcccctc aactccttct tcgcccaccg ccacccgctg ctcgccgcgg acccggagcc
    11041 caccgccacc gccgactaca ccgcgtgggc gctgcgcatc caccgcgccg tagaggaggc
    11101 cgtcgagaag gtccacgcgc ggggcgtcgt cttcaacgac ctccacatgt tcaacatcat
    11161 ggtcgcgccc gacgaagact ccgtcgtcct catcgacttc gaggccgccg cccccgaatc
    11221 cgagcacggc cggcaggtcg tggcccatcc cggtttcttc gccccgccgg accgccgcgg
    11281 cgcggacgtc gaccgctacg ccctggcctg tctgcggctc gcgctcttcc tgccgatcac
    11341 cacgctgttc gtgatcgacc gggccaaggc ggcgcacctg gccgacgtga tcgccgaaca
    11401 gttcccggtg ccgcgggagt tcctcgacga ggcggtggcg gagatcacgc gcgggacgga
    11461 gcccgcggag gccgctgagc ccgtggaggc cgaggaggcc gtccgggagg cggccgagcc
    11521 cgctccttcc gcggcctccg gaccgcccgg gcgccgcacc cgcaccctcg ctcccggcgc
    11581 cggacacgcc ctgcccctgc acgaccttcc cgaccccgcc gaggactggc ccggcgcccg
    11641 cgcgtccatg gtccgcgccc tcctcgcctc cgccacgcca gggcgggacg accgcctctt
    11701 ccccggggac atcgcccagt tctccgaggg cggcggcctc ggcctcgccc acggcgccgc
    11761 cggggtcctg cacgccctcg ccgaagccgg cgccgagcgc tacgaagagg gcgagcagtg
    11821 gctgctgcgc cacaccgacc ccgtgccgtc cggcaccccg ctcggcctct acgacggcct
    11881 cgccggcgtc gcctgcaccc tcgaccggct gggccacacc cggcgcgccc tggagctgtc
    11941 cgggctcatg ctcggcgagc agtggcagcg cctcacctcc gacctgcgca gcggcctggc
    12001 gggcgtcggc ctcgccctcg accacctcgc ccgcaccacc ggcgaacgcc agctgcacga
    12061 ccaggccgtc gaagccgccc agctcctcgc cgaccggctc gccgccgact cctccggcca
    12121 gggggaggac ggcagcggcc cccgccggcg cgccggcctc atgcgcggcg cgagcgggcc
    12181 cgccctgctc ttcctgcggc tgtacgagcg caccggcgcc cccgccctcc tcgacctcgc
    12241 cgagcaggcc ctgcgcacgg acctcgcccg ctgcacccgc acggcgggcg gcaccctcga
    12301 agtcgacgag ggctggcgca ccatgcccta cctcggtgac ggcagcgccg ggatcggcat
    12361 ggtcctggac gacttcctcg cccaccaccc ggaccccgac ccgtacttca ccgatgcccg
    12421 cgacggcatc ctcaccgccg cccggtcgcg cttctacgcc cagcccgggc tgttccaggg
    12481 ccgggccggg atgatcctgc acctcgcccg caccaccgcg cccggcgcga cccccgggca
    12541 cctggccgcc caggtccgcg ggctgtcctg gtacgccatg tcctaccagg gcgaactcgc
    12601 ctaccccgga agccagatga tgcggctgtc catggacctc gccaccggaa cggccggctg
    12661 cctgctcgcc ctcgccgccg ccctcgacga cgacggcgcc cggcccgcag gggccgcgcc
    12721 cgcgcagctg ccgttccttc cgcccctgcg ggggccccgg agccggctcc atgccgttgt
    12781 ggagccgtag caagaaaagc aacaccagca agaaaagcaa caccggcaac accggcaaga
    12841 acagtaagac gcacacaaag aaaccgaacc ccgtccccac gggaacccca cgaaaggaac
    12901 acgaccatgg cgcttctcga cctgcagaac atggagtccg acgagaacac cggtcacggt
    12961 ggcggtggcc agagcacggt cagcctgctc tcctgtgtca gcaccgccag cgtgctgatc
    13021 tgtctctgat ccggcacccg gatccgtctc cggtccggca ccggaccgga cgctgagcag
    13081 gcaccgggcg ggcccctcct gcgacgaggg gcccgcccgg gtccgcattc gcctgcggac
    13141 actttcccta cggatggtac ggacgcgagg gccaccgatc catggcacac acccgcaccg
    13201 ccacggcctc caccggagac cggctgctgc tcggcaccgc ccggcacagc gccgcccggg
    13261 ccgccgcgct cgccctcctc gcggtcgcgt ccaccggggc ggccctgctg ctgcccgtca
    13321 ccctcggcca caccctcgac ctgctcctcg cccgccgcgg cgccgacacc ggccgctggg
    13381 tcggcctgtg cgcgctcctc gtcgccggcc ccgccgccct cgacgcgctc gccgaactcc
    13441 tcaccggcac cacggccgcc cacgccaccg cccggctgcg ccaccggctc ctcggccacg
    13501 tcctcgccac gggcccgcag gccaccggcc gcttcccgcc cggcgacctc gtcacccgcc
    13561 tcgtcggcaa cgccgccgac accggcaccg ctcccgccac gctcgcccac gccgccgcgt
    13621 ccgtggcggg ccccgtcggc gggatcgtcg ccctcggcct catcgacccc cggctcgcgc
    13681 tcgccttcct cgccggcgcg ccactgctcg ccgtcctcct gcgcgccttc acccgcgcct
    13741 ccacggactg cgtcgcccgc taccagcagc tccaggggga catcgccggg cgcctggtcg
    13801 aagcgctcgg cggggcgcgc accatcgccg ccgccgggac cacagcccgg gaagaggccc
    13861 gcatcctcgg accgctgccg gggctctccc gcgaggggca ccgcatgtgg cgcgtccagg
    13921 gccgctccac ggcccaggcc ggcacgctcg tgccgctgct ccagatcacc gtcctcgccg
    13981 tcgccggcct ccggctctcc cagggcctcc tcagcgtcgg ggacctcctc gccgcatccc
    14041 gctacgccgt gctcgccacc ggcgtcggca tgctcgtcgg ccacctcaac gccgcggccc
    14101 gcgcccgcgc cgcggccgcc cgcgccgcgg aagtcctcgc cgtgcccgca gccccgtacg
    14161 gcgagcggct gctgccgccc gggcccggca ccctggaact gcggggcgtg cgggcggcgc
    14221 gcggcggccg gacggtcctg caggacgtca ccgtgacggt gcccgggggg agttcactgg
    14281 cggtcgtcgg acgatccggc agcggcaagt cggtcctcgc ggaagtggca ggccgcctcg
    14341 ccgaccccga cgccggcacc gtcctcctcg acggcgtccc cctctccgcc ctccgccacc
    14401 acgacctgcg ccgcgccgtc ggctacgcct tcgcccggcc cgcgctgctg ggcggcacgg
    14461 tcggaggcac gatcggcttc ggggcggtca cgccggggcg cgaggtgcgg gaggccgcgg
    14521 cgcgggcggc gtgcgcggac gacttcgtac ggcgcctccc gcacggctac gacacgccct
    14581 gcgcggacgc ccccctctcg ggcggcgagg cccagcgcct gggcctcgcc cgcgccttcg
    14641 cccacgcggg ccgcctcctc atcctggacg acgccacgtc cagcctggac actgcgacgg
    14701 aacgccgcgt cacggcagcc ctccacgcgt cgtccgcccc cacgcgcgta ctgatagccc
    14761 accgcgtgac gacggccgcg agcacggacc gcgtcctgtg gctccacgag ggaagagtgc
    14821 gggcggtggc cccgcacgcc gaactgtggg acgacccgga ctaccgggcg gtcttcgatg
    14881 cgtgaggcga cgtcatgacc gcgggcccgg ccgacgtggg caagccgctc cgcggcggag
    14941 cccgcgggcg caggacggcc tgtccggcta cggggccgcg ggcttgccct tcccgccgcg
    15001 acggcgagcc gccccgtggc ggcttccggc ggtgccgggc cggtctcggc tgtcaccggg
    15061 ggagttgtcc ggcggtgtcg acccggtggc tggagccggc cgggtgtcag ccactcctct
    15121 tccgccgcga cggcgagtcg tcccgcggcg gttcccggcg gtgccgggcc ggtctcggct
    15181 gtcaccgggg gagttgtccg gcggtgtcga cccggtggct ggagccggcc gggtgtcagc
    15241 cactcctctt cctccgcgac ggcgagtcgt cccgcggcgc gtcccggcgg tgccgagtcg
    15301 gcccttctcg tggcggcggg tgtcatccgg cgatgccgga cgggctgccg aaagcagctg
    15361 ggccgcagcc gccctcctcc gccgcgacgg cgagtcgctc cacggtggag tccggcggtg
    15421 ccgaccggac ggaccggccg agccggccgg ctgcgggggc gtcggcccgc tccttccgcc
    15481 gcggcggcga gccgaaccgt ccctgccggg cggaccgcac gcttccgcgc tcaccctgga
    15541 ggtccccgtg acacccgttg agcccgggct cgcccggcga ggggtccgtt atctcgcccg
    15601 gcggcgacgc gtcgtcgcgg cgctgctcgc ctggtccgtc gtggaggccg ggcacacctt
    15661 cgccctgggg tacgcgctgg ccgaggcgct cgacgaaggg tttctcgccg ggcgcccccg
    15721 taccggcctc gcctggctcg gcctggccgc cgtcgccgtg gtcgccgggg cgtacgggac
    15781 ggggcgtacg tacggcggcg tcgccggact cgtggagccc ttccgggacg ggctcgtgcg
    15841 gacggtcgtc tcccgcgccc tgcaccgcgg cggcggcagc gacaccgcgg ccgtgtcccg
    15901 gctgacgcac caggtggaga tcgcccgtga cgccttcgcc ggcctggtca tggtctcgcg
    15961 gtcgttcgtc ttcaccgcgg ccggcgccct gacgggcctg ttcctgctcg cacccccgct
    16021 gctggcggtc gtcgcaccgc ccctcgtcct ggggctcggc ctgttcctgg cgacgctgcg
    16081 cccgctcgcc cgccgccagg aggcgtacct cgccgcggac gagaccctcg ccgccgggct
    16141 cggcgacgtc ttcgccggcc tgcgcgacgt cacggcggcc ggcgccgagc cccgcgtccg
    16201 cgcggagacc ggcgccctca ccgatgccac gctgcacgcc tcccgctcgc tcgcgcgctg
    16261 gtccgtcgta cgggtcgtgg cgctcgccct ggccgggcag ctgccggtgg tgctcctgct
    16321 ggcgggggcg ccgtggctgc tggaccacgg cgtcaccgcg ggcggcctcg tgggcgcgct
    16381 cgcctatctg acgcagtccc tcatgcccgc gctgcagaac ctcgtccacg gcctcggtac
    16441 gagcggctcc cgcctcgccg tggtggtgcg caggctcacg gcgccgggtc tgcccgacgg
    16501 cccgccgggc gaaccggcag ccacagcaac agccgcacca caggacgccc cagcccccgc
    16561 gctcgccctg cgccgcctca ccttcgccta cggcgaccgc gccgaccccg tcgtacgcga
    16621 tctggacctg accctgcccc ggggcgcgca cctggccgtc gtcggcccca gcggcgtcgg
    16681 gaagtcgacg ctggccgggc tggtcgcagg cctcctgcgc ccgggcggcg gcgaggtcac
    16741 cgtgggcggc gcccgggccg gcacggcggc cgccgccgca cggcgggtgc tgattccgca
    16801 ggaggcgtac gtgttctcgg ggaccgtcgc cgacaacctc ggctatctcc gggacgaccc
    16861 cgtcccggag gaggagctgc gggccgctgc ggaggcgctc ggcatggcgg aactcgtccg
    16921 ccgtgtgggc ggcttcgccg cccccctcgc cccggcggag ctttcggcgg gggagcggca
    16981 gcagatcgcc ctggcacggg cctatctgtc gcccgccccc ctcgccgtgc tggacgaggc
    17041 gaccagccac ctcgaccccg tcgcggaggc ccgcgcagaa cgggccttcg cgagccgccc
    17101 cggcggcacc ctcgtcgtca tcgcgcaccg ggccgcctcc gcccgccgtg cgacccgcat
    17161 cctggtgatg gacggcgcgg acacggtctg cggggagcac cacgagctgc tggcgcggtc
    17221 cccgctctac cgcgacctca tgggcgccgc cgacccggcc caccgaggcc ccgagccccg
    17281 gaacccggca caccgggacg gctcttcatg ccgagacagc ccctcatacc caccccgccc
    17341 cctgcgagat acggatcgcg tcgacccggt tccgcgcccc ggtcttccgg gtgatcgcgg
    17401 ccatgtagtt gcgcaccgtc ccgttggaca ggtgcaggct gctggcgatc tccccgacgg
    17461 acgccccctc cgccgcgagt gacagcacgc tcagctcccg tctcgtcagc gggatctcag
    17521 cggcctccag gaagccgaag ccgagcgtct cgtcgatgta ccgctcgcct ttcgccacat
    17581 gccttatccc ctcgaccaac cggtcgggag aagcgttttt gctcaagtac cccagagcct
    17641 tctcctcgta cgcccggcgc agcggccccg gccgccccgc gctggccagg gcgagcaggg
    17701 ccgccctgtc gtcgcgcgcg tcaccgtgcc cggacagctc ccgcaggccg cccggcccgc
    17761 ccgcctccgg gctgtccatg tccaccacgc acacgtgcgg ccgcagcgag tccgacatga
    17821 ccaccgcgcg ttgccacgat gccgaggaga cctccaggtc cggctctctg ccgaggagag
    17881 ccgccagtgc cgcccgcagc agataggtgt catgcaccag aagcacccgg atcacggtcc
    17941 ccgccttccc gctcccccgc gcagcgagtg ctgcgccgga cacgacgctc attcataccg
    18001 gcgtgtgcca ccgctccggg cgcgtatacc ggacatggag ggggcgcaag ggcgcatgaa
    18061 ttccgccacg tgcgccccaa gttcactcga aagcgccccc catgaatcgg gtgccggggg
    18121 tagcgcgtca ggcctgctgt ggggtagtga gccgaatgag ccggcagacg gtctcgatgt
    18181 cgatccgcac ctgtgcgatc gaagcgcgcc ccgagagcca ggtgatgagc gccgagtgcc
    18241 aggtgtgctc gatgacgcgg acggcggaga gctgctcggg ggtgggcggc ccggccggtc
    18301 ccatggcgtc gaggatgatc gtcgtggtga gccgggagac ggtgtcgacc tcggagctca
    18361 ccgagcggtc ggcgaaggtg agggcgcgca ccatcgcatc ggccaggtgc ggctcgcgct
    18421 gcatggcgcg gaaggcccgc atcagggtct gggccacgcg cgcggccggg tcggcgtccg
    18481 tcggcgggcg cttgcgcagc gtcccgtgca gccgctgcag ctggtcctgc atggtggcga
    18541 ccagcaggtg gatcttggag gggaagtagc ggtagagcgt gccgagcgcg acgcccgccg
    18601 cctcggcgac ctcccgcatc tgcacggcgt cgaagccgcc gcggctcgcg agctccgcgg
    18661 tggcctgcag gatccggcgg cggcgggcct cctgacgctc ggtcagggga aggctgggcc
    18721 cggcgggcac ggcccgcgcg gtcggcgact tgggttccgt cgtcatatgt cccattccgt
    18781 ggcaatccat ccaggggtgt ctgtccggcc cggacggcac agcatggcag gggccgggcc
    18841 gtggcgcgaa tcacccgatc cggtcctgga gaccgccctt ccggccggta gattcgaggc
    18901 ttctggacga cccagtctga aacttgttct agattagcgc gaccggttac gctccggccg
    18961 gaacagcagc cagaaggagg ccgggggagt gaccgctgag gccactgagg cagctctcgc
    19021 agatgcggcg gcgcgcgagg cgcgcgcggg gcaggacgca cggaacgacg gcctccggga
    19081 cggggacggc gaccgccccc tgcggatcgc gctgctcacc tacaagggca acccgttctg
    19141 cggcggccag ggcgtctacg tccgccacct ctcccgtgaa ctcgcccgcc tcgggcacag
    19201 cgtggaggtc atcggctccc agccgtaccc cgtcctcgac gagggcgtga ccctcaccga
    19261 gctcccgagc ctcgacctct accgccagcc ggaccccttc cgtacgcccg gccgcgacga
    19321 gtaccgcgac tggatcgacg cgctggaggt ctccaccatg tggacgggcg gcttccccga
    19381 gccgctcacc ttcagcctgc gcgcgcggcg tcatctcgcc gcgcagcgcg gccggttcga
    19441 cgtcgtccac gacaaccaga ccctgggcta cgggctcctc ggcggccccg ccgcgatcgg
    19501 cgctccgctg gtgaccaccg tccaccaccc catcaccgtc gaccggcagc tcgacctcgc
    19561 cgccgcggcg gactggaagc ggcgggcctc cgtgcggcgc tggtacggct tcacccggat
    19621 gcagaagcgg gtcgcccggc ggctgccgtc cgtgctcacc gtctccggct cctcgcgcca
    19681 ggagatcgtc gaccacctcg gcgtccgggc cgagcgagtg cacgtcgtgc ccatcggcgc
    19741 cgacacggac ctgttctcgc cggacccgtc cgtgcccgag gtgccgggcc ggatcgtcac
    19801 cacctccagc gcggacgtgc ccctcaaggg cctggtgcac ctgatcgagg ccctggccgt
    19861 ggtccgccgc cggcaccccg cagcgcacct cgtcgtcgtc ggcaagcgcg ccgaggacgg
    19921 gccggtcgcc accgcgatcc ggcgctgcgg gctggagaac gccgtcgagt tcgtcaaggg
    19981 catcaccgac gccgaactcg tcgacctcgt gcggtcggcg caggtcgcct gcgtgccgtc
    20041 gctgtacgag ggcttctcgc tgccggccgc cgaggccatg gccacgggca cgccgctggc
    20101 ggccaccacc ggcggcgcca taccggaggt cgcgggcccc gacggggaga cctgcctcgc
    20161 cgtcccgccg ggcgaccccg gggcgctcgc ctccgccctg ggccggctcc tcgacgaccc
    20221 cggactccgc cgccgcctcg gcgccgcggg ccgcgaacgc gtcctgtccc gcttcacctg
    20281 gcgcgaggcc gcgatcggta cggcgcggca ctaccgcgag gcgatcgccc tcgcgggcgg
    20341 cgcccgaagc gccggacggc ccgcctgatg ccgggcgcgg caccgcacgc cacgcggcgg
    20401 gcggcttggc accgccggtc gggcacgact gcgctgccga cgacaagcgc ttgccgtagc
    20461 ggcgctcagc tgcagcgtcg cgttccggcg gcgccggacc aggcctgttc ggcaccgccg
    20521 gagaccgccg cggggcttgc tcgccgttgc ggcggagggt tcttcgggcg cggcggcagt
    20581 gccgcaggct atgtcctgcc gccggcagaa accccccgcc gcagcggtgc tcagccgcat
    20641 cggcgcagcc cggcggtgcc gggccgggcc tgttcggcac cgccggacac ggctgcgggg
    20701 cttgctcgcc gttgcgccgg agggttctcc gggcgcggcc gcagcgccgc aggccacgcc
    20761 ctgccaccgg cggaaatctc ccgccgcagc ggtgctcagc cgcatcggcg cagcccggcg
    20821 gtgcccgacc ggggccaccc ggtggcgtcc cgctccggtg acccgggccg gaggccctcc
    20881 gtttccgcaa tcaaccaccc cgtcccgccg gccgaaggca aatacccgtg ctgaccgtcg
    20941 atttctcccg cttcccgctc gccgcaggcg accgcgtcct cgacctgggc tgcggcgcgg
    21001 ggcggcacgc cttcgagtgc taccggcgcg gagcgcgcgt cgtcgcgctg gaccgcaacg
    21061 gcgaggagat acgcgaagtc gccaagtggt tcgcggccat gaaggaggcc ggtgaggcgc
    21121 cacccggggc caccgccacc gccatggagg gtgacgccct cgcgctgccc ttccccgacg
    21181 acagcttcga cgtcgtcatc atctccgagg tcatggagca catcccggac gacaagggcg
    21241 tgctcgccga gatggtgcgc gtcctcaagc cgggcggccg gatcgccgtc accgtcccgc
    21301 gctacggccc ggagaagatc tgctgggcgc tctcggacgc ctaccacgag gtcgagggcg
    21361 gccacatccg catctaccgc ggcgacgagc tcctggaccg catgcgcgag gccggcctcg
    21421 tcccgtacgg cacccaccac gcccacggcc tgcacagccc ctactggtgg ctcaagtgcg
    21481 ccttcggcgt cgacaacgac aaggcgctgc ccgtccgcgc ctaccacaag ctgctggtct
    21541 gggacatcat gaagaagccc ctggccacca gggtcgccga gcaggccctc aacccgctca
    21601 tcggcaagag cttcgtggcg tacgcgacca agccgcacct gcccgccacc gggacggacg
    21661 cgtgactctc ttcagccgcg gctccggccg caccgagcgc ctcgtgctgc ccggcgtcct
    21721 gaccgccgaa caggtcacgg gcaccgtcgc cggcatcgcc gccgtccagc gcgaggacgg
    21781 cgccatcccc tggttccgcg gccaccacct cgacccgtgg gaccacaccg aggccgccat
    21841 ggccctcgac gccgcgggcg agcacgaccg cgccgaggcc gcctaccgct ggctcgcccg
    21901 ccaccagaac tccgacggct cctggtacgc cgcctacgcc gacggtgccg ccgacgagcc
    21961 caccgaccgc tcccgcgagt cgaacttcgt cgcctacgtg gccgtgggcg tctggcacca
    22021 ctacctcgcc accggcgacg acgccttcct cgacagcatg tggccgaccg tctacgcggc
    22081 cgtggagttc gtcctggcgc tccagcaggc cggcgggcag atcggctgga agcgcgagga
    22141 ggacggcacc cccgtcacgg acgcgctgct gaccggctcc tcgtccatcc accaggccct
    22201 gcgctgcgcc ctggccatcg ccgagcaccg cgaggagccg cagccggact gggagctggc
    22261 cacgggcctg ctcgcgcacg cgatacgccg gcacccggag cggttcctcg acaagagccg
    22321 ctactcgatg gactggtact accccgtcct cggcggcgcg gtcaccggcg tcgccgccaa
    22381 ggagcgcata gaggagggct gggaccgctt cgtcgtcccg ggcctgggcg tgcgctgcgt
    22441 gctgcccaac ccgtgggtga cgggcggcga gagctgtgag ctcgccctcg cgctgtgggt
    22501 gatgggggag tcggaccgcg ccgtgcagat cctgcagtgg atccagcacc tgcgggccgc
    22561 ggacggcatg tactggacgg gctacgtcta cgacgacgac gccgtctggc ccgaggagcg
    22621 caccacgtgg acggcgggtt cgctgctgct cgcggcggcc gcgctcgggg gcgacgaggc
    22681 gacgaccgcg gtgttcggcg gggaacggct ccctgcgggg ctggagccgg actgctgcgc
    22741 gtagcgcctc tgaacgggtc cctccgcgtg gcgggcggct ggccggaacg
//
