LOCUS       NZ_BMUQ01000036        22226 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces mirabilis strain JCM 4551 sequence36, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUQ01000036
VERSION     NZ_BMUQ01000036.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces mirabilis
  ORGANISM  Streptomyces mirabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 80157)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 117X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650275.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:52:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,311
            Genes (coding)                    :: 9,898
            CDSs (with protein)               :: 9,898
            Genes (RNA)                       :: 81
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 414
            CDSs (without protein)            :: 413
            Pseudo Genes (ambiguous residues) :: 0 of 414
            Pseudo Genes (frameshifted)       :: 172 of 414
            Pseudo Genes (incomplete)         :: 329 of 414
            Pseudo Genes (internal stop)      :: 40 of 414
            Pseudo Genes (multiple problems)  :: 115 of 414
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 11816
            Orig. end                         :: 34042
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUQ01000036.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22226
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22226
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22226
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12226](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12226)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(352..1386)
                     /locus_tag="IE289_RS47080"
                     /old_locus_tag="GCM10010317_096830"
     CDS             complement(352..1386)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007823357.1"
                     /locus_tag="IE289_RS47080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096830"
                     /product="hypothetical protein"
                     /protein_id="WP_190174317.1"
                     /transl_table=11
                     /translation="MSFTTPPRPFDITALFPQLAPLARTATRLHPRPGSPTVHDSSVGG
                     PLLWPADEPWPHCEEPHNSRVAPVVHSPDDVRLFRHGRAAAAERLRLDPEAPWWTPEER
                     ATWERLAGRPWFDGPIPLLPVAQLYARDVSFPCPPDADLLQVLWCPFDHEMAHPRTALF
                     WRSSATVTDVLDAPPEPPIVQLDCYLPEPCLFSPEQVTEYPNPRELSKELRDQLDDMSR
                     WETIDPARYNTYAYDPGELYLNNLSTAPGWKTGGWTRWDPTDPIDRPCPECGTEEVPLL
                     TIASSEWDGGSETWIPEEERTNPTPVPLGTQAGDFTEIGIAGGYNLQLHVCPVSPDHPH
                     IALV"
     gene            complement(1475..2521)
                     /locus_tag="IE289_RS47085"
                     /old_locus_tag="GCM10010317_096840"
     CDS             complement(1475..2521)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007823357.1"
                     /locus_tag="IE289_RS47085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096840"
                     /product="hypothetical protein"
                     /protein_id="WP_190174318.1"
                     /transl_table=11
                     /translation="MSFTTPPRPFDVTALFPQLAPLARTATRLHPRPGSPSVHDSSVGG
                     PLLWPADEPWPHCEEPHDREAADEMHSSDDIRLLRRIRAAAAERRLRAPQAPAITPEER
                     EIEQRLREGHPWFDGPIPMIPVAQLYTRDVPLPVSPPGADLLQVLWCPCDHSEFAHPRT
                     ALFWRSSASVTDVVDAPPEPPVIQFDWYLPEPCLLAPEQVTDYPSPMELSKELQQQLGD
                     VSRWETAGFAWDSTGAMDPQEFYFRNLCHAPGWKTGGWTRWGLTDPMPRPCPECGTETT
                     PLLTIASSEWNSGSKSWMPDEERTNPTPLLIGTPPANFTLLDIAGAYDLQLHACPVSPD
                     HPHIELVQ"
     gene            complement(2554..2712)
                     /locus_tag="IE289_RS52440"
                     /old_locus_tag="GCM10010317_096850"
     CDS             complement(2554..2712)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE289_RS52440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010317_096850"
                     /product="hypothetical protein"
                     /protein_id="WP_229889581.1"
                     /transl_table=11
                     /translation="MTPVYKDAKSTIPVGVTMNANIERANGTTEELFSNVYVTNTLKNT
                     GLYNLGN"
     gene            complement(2709..3368)
                     /locus_tag="IE289_RS47090"
                     /old_locus_tag="GCM10010317_096860"
     CDS             complement(2709..3368)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025298.5"
                     /locus_tag="IE289_RS47090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096860"
                     /product="DNA/RNA non-specific endonuclease"
                     /protein_id="WP_229889582.1"
                     /transl_table=11
                     /translation="MIPNLGNGEWDTYILNDARVVDPASPCVQAHVTLDEKQFADTQLA
                     NGFKDQRVIDADQFELTFSLPDTGPHASCLNDPPPVNSIPNGDGWFWNTTEAVPLVNQS
                     DPAGGGGERPTQAQACLGRKTGGGKGTSNPVTGWKDAEAFKTANNLTYGLSRCHLIASI
                     LGGRGNDALTRTNLVPCRQSGMNTGTPSMRTFESKAQNMIQGPSPISERTTRSSTR"
     gene            complement(3472..3606)
                     /locus_tag="IE289_RS53010"
     CDS             complement(3472..3606)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE289_RS53010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268256106.1"
                     /transl_table=11
                     /translation="MSDGRRQMAALRKANTPPMMTTVSVSHGPTLPPEVLMALDEEDA"
     gene            3821..>3922
                     /locus_tag="IE289_RS52445"
                     /pseudo=""
     CDS             3821..>3922
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675938.1"
                     /locus_tag="IE289_RS52445"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="3-oxoadipate enol-lactone hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSETPMNTLQYRFDGPEDAPVLILGPSLGTTWHM"
     misc_feature    complement(3928..3939)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.72"
                     /tool="antismash"
     misc_feature    3982..3996
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.43"
                     /tool="antismash"
     misc_feature    complement(4015..4030)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            4605..>4775
                     /locus_tag="IE289_RS52450"
                     /pseudo=""
     CDS             4605..>4775
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143215.1"
                     /locus_tag="IE289_RS52450"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS110 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSSSTSRAPQHPRRRPAGEVVLGVDTHRDAHVAAVLSGTGTVLAT
                     GEFTATAAGYRA"
     gene            <4778..5164
                     /locus_tag="IE289_RS52455"
                     /old_locus_tag="GCM10010317_096890"
                     /pseudo=""
     CDS             <4778..5164
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327179.1"
                     /locus_tag="IE289_RS52455"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096890"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /pseudo=""
                     /transl_table=11
                     /translation="IAVAGHLPPVLMRAGEPPELLDLPTGAALGVGGVAFEVTTFGLAP
                     GDQLVLYTDGLVETRHHAIDERLDLLLQLLHRPDRSSEETCDRLLDTLRDPDDHDDVAV
                     LIARARRWPRPKRAASRAEDVAML"
     gene            complement(<5125..5316)
                     /locus_tag="IE289_RS52460"
                     /pseudo=""
     CDS             complement(<5125..5316)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075152.1"
                     /locus_tag="IE289_RS52460"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="amino acid permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKRRVGVSDAVLIGLGSVIGAGIFAALDPAAGAAGSGLLLALALA
                     AAVAVAYSIATSSARLAAL"
     gene            complement(5742..6332)
                     /locus_tag="IE289_RS47100"
                     /old_locus_tag="GCM10010317_096900"
     CDS             complement(5742..6332)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357914.1"
                     /locus_tag="IE289_RS47100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096900"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190174320.1"
                     /transl_table=11
                     /translation="MPYDSAATRAKILGAAIEEFSTYGFAGARIERIAEAADANKRSIY
                     VYYTNKELLFAAALHKVISELNDAVPLTEDDLPGYAGRMFDYLTQRPAALRMHLWRQME
                     RPELGPDAADVYSEKMARMTADSTAGQLPSTDLLVLITGLTQSWVLAPRDLLTAVDGAD
                     PYRPERLAEHRAVIVEAARRLCAPAPKARATAS"
     misc_feature    6351..6366
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(6357..6370)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.15"
                     /tool="antismash"
     misc_feature    6395..6409
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.15"
                     /tool="antismash"
     gene            6439..7926
                     /locus_tag="IE289_RS47105"
                     /old_locus_tag="GCM10010317_096910"
     CDS             6439..7926
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012398.5"
                     /locus_tag="IE289_RS47105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096910"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_190174321.1"
                     /sec_met_domain="Aldedh (E-value: 1.1e-159, bitscore:
                     524.2, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTSSSPVFERDLFINNTWRPGSSGERVPVVDPATEKEIGSAA
                     AAAFEDIDAAVDAARTAFDSGPWPRLTLQERAEILTRFAEELEKDVDPVTEVLVAETGL
                     TVGQSRGGALTMPGLLRYYASLADTTELTELRTGLSGVSARIEKRPVGVVAAIVPWNAP
                     LALAAFKLPQALLAGCTVIMKPSEDTPLSAGYFADAALRAGLHAGVLNIVNALPAGGDY
                     LVRHPGVDKITFTGSTVVGRRIAAAAADTLKQLTLELGGKSPALVLDDADLDRIVETLV
                     PGVTGNNGESCTNPSRLIVPEHRHDEIVGALAEAFAKLTVGDPRDPSTDVGAMVTRKHY
                     ERVLDYLASAEEEGGTFAVGGGRAPGHDVGYYVAPTIITGVSPDAKVAQEEIFGPVLTV
                     LTYRDEDEAIRIANHTEFGLSGAVYSTDTERALRVAQQIHAGTVNLNNGITVDIGVPFG
                     GVKQSGYGRELGPEGLDAFFNTHVIFLNGEPLRVIKG"
     gene            8018..8959
                     /locus_tag="IE289_RS47110"
                     /old_locus_tag="GCM10010317_096920"
     CDS             8018..8959
                     /NRPS_PKS="Domain: PKS_KR (26-112). E-value: 8.4e-09.
                     Score: 27.5. Matches aSDomain:
                     nrpspksdomains_IE289_RS47110_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669772.1"
                     /locus_tag="IE289_RS47110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096920"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_190174322.1"
                     /transl_table=11
                     /translation="MRIATPFTASSTAMDVIAGVDLTGRAMIVTGASSGIGVESARALA
                     AGGAHLTLAVRDLDAGQRTADDIAATTGNDRVSVRRLDLTDLDSIDAFAAGWNGPLHAL
                     IHNAGVMETPQRYTRYGWELQFATNHLGHFALTLALHDALAEAATTTGEARIVAVSSSG
                     HGSSPVRFDDLFFRRRPYDPGHAYGQSKTAQILFAVEATRRWAQHGITTNALMPGGIWT
                     NLQRHWDPDRRARLKAAIPGKTPQQGAATSVLLAASPRLQDISGRYFDDCNEAEPVEEI
                     IDGLHGVRPWALDKDAARRLWDVSLALIDAAQ"
     aSDomain        8096..8353
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE289_RS47110_PKS_KR.1"
                     /evalue="8.40E-09"
                     /label="IE289_RS47110_PKS_KR.1"
                     /locus_tag="IE289_RS47110"
                     /protein_end="112"
                     /protein_start="26"
                     /score="27.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="MIVTGASSGIGVESARALAAGGAHLTLAVRDLDAGQRTADDIAAT
                     TGNDRVSVRRLDLTDLDSIDAFAAGWNGPLHALIHNAGVME"
     CDS_motif       8099..8179
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE289_RS47110_0001"
                     /evalue="2.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE289_RS47110"
                     /protein_end="54"
                     /protein_start="27"
                     /score="14.0"
                     /tool="antismash"
                     /translation="IVTGASSGIGVESARALAAGGAHLTLA"
     gene            complement(<9368..>9484)
                     /locus_tag="IE289_RS52465"
                     /pseudo=""
     CDS             complement(<9368..9484)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007819287.1"
                     /locus_tag="IE289_RS52465"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHADGGLPVADGAASFQEAVADVLIRKAVAACTDAGAGT"
     misc_feature    complement(9515..9524)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     gene            complement(10001..12226)
                     /locus_tag="IE289_RS47115"
                     /old_locus_tag="GCM10010317_096930"
     CDS             complement(10001..12226)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024122.5"
                     /locus_tag="IE289_RS47115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096930"
                     /product="haloacid dehalogenase-like hydrolase"
                     /protein_id="WP_190174323.1"
                     /sec_met_domain="T2TS (E-value: 1.5e-55, bitscore: 181.1,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIAVLDVDGTLIAGTLAGPLPTMLAEAGLVPRDRLARLRRAQVT
                     SDAEDPQAAARMNELFAAMLTDVPCRAVSAVTARLWQRQRNRLFNFTRPLTAALKEAGY
                     VPLLISGGPQEMVAYLACELGVTLFRGTQFEAADGLFTGRVAAPVADGKDRAAQDLVGA
                     GRIDWSGSLAVGNSLGDVSSLSRVGRPVAFEPSPALRALARHHSWPVCDRTSLLTYLRD
                     QAALPVSPPAPARDMRSAHRAALPASVSRVTRLLTERLLAQVGGQGAVTGECSSRVTES
                     ALMLTLLRRQKALSGVQSRLHAYLSRSRAAADAFDAAVIDATLDGIPASDRHRLIEQTF
                     DGAAQHSSDRKKLALEAILAVVGPEPFHVDVPSHAFEHHNEATWTRLRQIAIHHLHVPD
                     PVAPQLTARLLRLTERGQDQGIIEGNVFAHLFALLSLQRTVPGHRVIHDGITALAKAVR
                     NDGGMPFIISEEIFCTATAGLALARAGADRQVLLAMGDYLAAQQAGNGGWAYAQDVVQT
                     DTDTTTHVLSFLHALGPERYRAHIHAARQFLAAYLGEDGGMPTYLPGQPSEPTMTANTI
                     TALQPYHFAHVPLLERATAYLLNAQKPDGTFERSWSLSEANAMLRALNALTLAHRHNPS
                     SHQGRLGPAIDSIHLRLLVTANPDGGWGQTPGEDSDPMSTAYTLTALASTHRTHPTVHS
                     GLHYLLGEQNPDGGYTSPSDQAAPRPLRYTIPVLTDIFVLRALTHYA"
     gene            complement(12495..13253)
                     /locus_tag="IE289_RS47120"
                     /old_locus_tag="GCM10010317_096940"
     CDS             complement(12495..13253)
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608033.1"
                     /locus_tag="IE289_RS47120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096940"
                     /product="urease accessory protein UreD"
                     /protein_id="WP_229889583.1"
                     /transl_table=11
                     /translation="MRATARIRAAHNGRVTTLPQLRSDGPFHLRRLRTDGNAATVGIIG
                     AMSAPLGGDRLTLDITAEDRAELEVTTAAATLALRGPTTDAATYDVRLTAGEHAHLRWL
                     PRPLISAAGSNLRQTYTVELAATSRFVLREEQLLGRADEEPGHLVTRILVHRGGRPLLD
                     QHTAYGAPEPGWNGPAVLNGHRAVGQLLVVDPRLDVRRDPVLLGEGAKDGCAVLAPLAN
                     GPALLATAVAPTTSTLRELLDEAHAHALAR"
     gene            complement(13346..14035)
                     /gene="ureG"
                     /locus_tag="IE289_RS47125"
                     /old_locus_tag="GCM10010317_096950"
     CDS             complement(13346..14035)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0016530 - metallochaperone activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0019627 - urea metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ureG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093168.1"
                     /locus_tag="IE289_RS47125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096950"
                     /product="urease accessory protein UreG"
                     /protein_id="WP_190174325.1"
                     /transl_table=11
                     /translation="MHLDHSLPHQHASSASATRPDGSRRALRVGLGGPVGSGKTATVAA
                     LCRTLRDRWCIAAVTNDIYTREDAEYLLREAVLPPERITAVETGACPHTAIRDDISANL
                     EAVEHLEATLHPLDLVLVESGGDNLTATFSKGLVDVQIFVIDVASGDDIPRKGGPGITT
                     ADLLLVNKTDLAPHVGADLDTMASDAKRQRGDLPVIFTSLTSDDGIGEVADWVTGHLTQ
                     WRAGATV"
     gene            complement(14074..14748)
                     /locus_tag="IE289_RS47130"
                     /old_locus_tag="GCM10010317_096960"
     CDS             complement(14074..14748)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543361.1"
                     /locus_tag="IE289_RS47130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096960"
                     /product="urease accessory protein UreF"
                     /protein_id="WP_190174326.1"
                     /transl_table=11
                     /translation="MSRAALLLLADGRFPAGGHAHSGGVEAAVAHGAVHDTHSLEAFCR
                     GRLHTTALTMAALAAAAAGGYDPLLLDNAADARTPAPALRAVARRLGRQMMRAARATFP
                     SAELDHLAAARPQGAHQPIVLGLAAHAAGLAPLDAAYAAAYENIGGPATAAVRLLSLDP
                     LDASGLLARLGPETDDVAQAAAGAATRAVTEGLDALPSASSPLLDITGEQHAAWSVRLF
                     AS"
     gene            complement(14864..16855)
                     /gene="ureC"
                     /locus_tag="IE289_RS47135"
                     /old_locus_tag="GCM10010317_096970"
     CDS             complement(14864..16855)
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0019627 - urea metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ureC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607071.1"
                     /locus_tag="IE289_RS47135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096970"
                     /product="urease subunit alpha"
                     /protein_id="WP_190174327.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 9.2e-66, bitscore:
                     214.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSQPEQTGRQRPSNLLKRADYTALYGPTTKDRVRLADTDLTIEI
                     EADWSGGPKSSGNEMIFGGGKVIRESMGMSHIPRDGGGKKDRRPVDTVITGALIVDWWG
                     VIKADVGIRDGRVHAIGKAYNPETMDPISDFEKPAREQAGEQLPVTATNFVVGPSTEVI
                     SGNGRILTAGGVDTHVHFICPEEIHEALASGVTTLIGGGTGPAEGSTATTVTPGAWHIT
                     RVFEALDEYPVNIGLLGKGSTMNKEALNEQVDAGVIGFKIHEDWGATPAVIDLALKVCE
                     DRKVQLALHADSLNESGFLESTKAAFKKRSIHIFHVEGAGGGHAPDMIELVKEPNVLPA
                     STNPTRPFTVNTVKEHVDMMVVCHHLNPDIPADMAFADSRIRPSTMAAEDLLHDMGAIS
                     MMSSDAQAMGRIGEMIMRTWQTAHVMKCRYGPLPEDLQSAKVRTIKDDEKDHSFNEDRL
                     KPNDNYRARRYVAKYTVNPAITHGIDKYVGSVEPEKLADLVLWEPKFFGVKTHMVLKGG
                     QLAYAQVGDANASITTPQPYLPRPVWGSTGLSPGSNSVNFAAPGVADRLNTRFVITQDS
                     SNKVTDAKTQGLGLKKKFVEITDTRGVKKDDMKLNDTWRLSLEVDHNSFEVTIGGATTS
                     DARTELNGATVPRSYVTEVPLAQRYFLF"
     gene            complement(16852..17355)
                     /locus_tag="IE289_RS53320"
     CDS             complement(16852..17355)
                     /EC_number="3.5.1.5"
                     /GO_component="GO:0035550 - urease complex [Evidence IEA]"
                     /GO_process="GO:0043419 - urea catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012902.5"
                     /locus_tag="IE289_RS53320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="urease subunit beta"
                     /protein_id="WP_308435136.1"
                     /transl_table=11
                     /translation="MVTIHDPLPEATEEPEVYPGKVEHPQPARSPECPVACDDTDPSAC
                     CAACEDAASWHEAIAFNRLLQSDKKTIKVRNTSDRPIQVGSHYHFAEVNPGLKVVVNPS
                     GGGVTYDELWTCAEAKGRRLNIAAGTSVRFEPGDECCVELVKIEGDAKSDTRKIQGLRK
                     GIVR"
     gene            complement(<17332..17628)
                     /locus_tag="IE289_RS53325"
                     /pseudo=""
     CDS             complement(<17332..17628)
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_function="GO:0016151 - nickel cation binding [Evidence
                     IEA]"
                     /GO_process="GO:0043419 - urea catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608038.1"
                     /locus_tag="IE289_RS53325"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="urease subunit gamma"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHLTPHEQERLLIHVAADVAGKRRDRGLLLNYPETMALLSVHVFE
                     AARDGKTVSDIMDSGRRVLTRDDVMDGVPEMIKNVQVEATFPDGTKLVTIHDPL"
     misc_feature    complement(17512..17514)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17596..17598)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17876..17888
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            18109..18993
                     /locus_tag="IE289_RS52470"
                     /old_locus_tag="GCM10010317_096990"
     CDS             18109..18993
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.5"
                     /locus_tag="IE289_RS52470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_096990"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_229889584.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6.2e-16, bitscore:
                     50.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVVVVGAGFSGIGAAIRLRQEGWRDLVVLEKASQLGGTWRENTY
                     PGCACDVPFSLYSYSFTPNPRWSRIFAGQREIHDYLRTTADRYGVGEVLRCGVRVLEAR
                     WDQNTGRWLVQTTDGKYRARVLVLATGPWHEPRRLDAPGLDEFPGPVFHTAEWDHSVDL
                     TGRRVAVVGSGASAVQVVPAVQDRAATVHLFQRTAQWLLPKPDLPVSPALNWCLDRIPG
                     IRRTLRAGQYGLQESIGYALRHPRLAGPLQTAARAHLRLTVRDPELRRALTPDHRLGCK
                     RLLTSSTFYPALA"
     gene            19084..19635
                     /locus_tag="IE289_RS52475"
                     /old_locus_tag="GCM10010317_097000"
     CDS             19084..19635
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE289_RS52475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010317_097000"
                     /product="hypothetical protein"
                     /protein_id="WP_229889585.1"
                     /transl_table=11
                     /translation="MITATGFRVGELPLARSVHGTAGRTLHETWAGDGPQAYLGTSVTG
                     FPNLFLLLGPNLLSGSTSAISVLEAQLAYLGAALRHPRREGHASMDVRPAVQAAYNTAV
                     QEALRTTVYNAGGCSSYYFHSSGRNTFCWPWSTGRLTRSLNRFDAAAYTCRAPSTPAPV
                     PAPRVVAEESFPADEEGITT"
     gene            19894..20136
                     /locus_tag="IE289_RS47150"
                     /old_locus_tag="GCM10010317_097010"
     CDS             19894..20136
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE289_RS47150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010317_097010"
                     /product="hypothetical protein"
                     /protein_id="WP_190174360.1"
                     /transl_table=11
                     /translation="MTSLLTASATCPQPLTVGEVILGVDTHRDVHVAAVLSWPGAVLGT
                     AVFAATASGYRLLLEWARGLGPVSRAGVEGTGSRR"
     gene            complement(<20141..20227)
                     /locus_tag="IE289_RS53750"
                     /pseudo=""
     CDS             complement(<20141..20227)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543124.1"
                     /locus_tag="IE289_RS53750"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="nicotinamidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSRALIVVDVQKDFREGGSVPVKGDAGRA"
     gene            20201..20755
                     /locus_tag="IE289_RS47155"
                     /old_locus_tag="GCM10010317_097020"
     CDS             20201..20755
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605347.1"
                     /locus_tag="IE289_RS47155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_097020"
                     /product="isochorismatase family protein"
                     /protein_id="WP_373306592.1"
                     /transl_table=11
                     /translation="MNDDQCTAHSTTLPHRTAENPDLVRRAAGSRYAHVVATRDHHVDP
                     GSHFSEHPDFKDSFPVHCVVGSDGSTFHPDFAPVVSQAVDEVFFKGAHSASKSGFEGSA
                     QDGTLLASWLRAREVTDVDVVGIATDHCVKATALDGVRAGFSVRVLLGYTAGVAADSTE
                     AAVTELRRAGIALTGKPVVLT"
     gene            complement(<20995..21977)
                     /locus_tag="IE289_RS47160"
                     /old_locus_tag="GCM10010317_097030"
                     /pseudo=""
     CDS             complement(<20995..21977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012814020.1"
                     /locus_tag="IE289_RS47160"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GCM10010317_097030"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGVPELIPTGSVFAFLAEHRDALFPEAMFTDMYPSSDGRPSVPPG
                     ELDARSCCRPCMVCRASRLSSTCGVI"
ORIGIN
        1 tgtcgtgcgg cgtgggcgac ccgggccggg gatgcagccg ggtcgccgtg cgtgccagcg
       61 gggccagttg agggaagagc gcggtcacgt cgaacggccg cggcggggtg gtgggactca
      121 tgtcggctcc cgatggcacg aactggctgt gatcagttac cgaggttgag caacctggtg
      181 ctcttcggca gtcaggccga gaccgcccag cggacgctcg ccggtgagga accgacggtc
      241 cgggtggacc gtactgccgg ttcgaggagc gacagcgtcc gctgctgccg tgcgtcaagg
      301 cggcgcggat accgaccggc atcggcaggt tcggtcctgc gcgaccggtc actaaaccag
      361 tgcgatgtgg ggatggtccg gggagacagg gcagacgtgg agttgcaggt tgtagccgcc
      421 ggcgatgccg atctcggtga agtcgccggc ctgggtgccc aggggaaccg gagtcgggtt
      481 cgtccgttcc tcctcgggga tccaggtctc gctgccgccg tcccattccg aggaggcgat
      541 ggtgaggagc gggacctcct cggtgccgca ctcggggcag gggcggtcga tggggtcggt
      601 ggggtcccag cgggtccagc cgccggtctt ccaaccgggg gcggtggaga ggttgttcag
      661 gtagagctcg cccgggtcgt acgcgtacgt gttgtaccgc gcaggatcga tcgtctccca
      721 gcggctcatg tcgtccagct ggtcccgaag ttccttgctc agctccctgg ggttggggta
      781 ctcggtgacc tgctccggtg agaacaggca cggctccggg aggtagcagt ccagctggac
      841 gatgggcggc tcgggcggtg cgtcgagaac gtcggtgacg gtggcggagg agcgccagaa
      901 gagggctgtc cgggggtggg ccatctcgtg gtcgaagggg caccagagga cctggaggag
      961 gtccgcgtcg ggcgggcacg ggaaggagac gtcgcgagcg tagagctggg cgacggggag
     1021 gagggggatc gggccgtcga accacgggcg gcccgcgagc cgctcccacg tcgcccgttc
     1081 ctcgggagtc caccagggtg cctcggggtc gaggcgcaac cgctcggccg ctgcggcgcg
     1141 gccgtggcgg aagagccgga cgtcgtccgg ggagtggacc accggcgcca cgcggctgtt
     1201 gtgcggttct tcgcagtgcg gccacggctc gtcggcgggc cacaggagcg gcccgccgac
     1261 ggagctgtcg tgcacggtcg gcgacccggg ccgcgggtgc agccgggtcg ccgtgcgcgc
     1321 cagcggggcc agctgaggga agagcgcggt gatgtcgaac ggccgcggtg gggtggtgaa
     1381 actcatgccg gctcctgttg gcgcgaactg ggtgggatca gttaccgagc tcgaacagcc
     1441 cggtgtcggt tcggtacccg ggcgtcgggc ctgctcactg gaccagttcg atgtgcggat
     1501 ggtccgggga cactgggcag gcgtggagtt gcaggtcgta ggcgccggcg atgtcgagga
     1561 gagtgaagtt cgcgggcggg gtgccgatga ggagcggagt tgggttcgtc cgttcctcat
     1621 cgggcatcca gctcttgcta ccggagttcc attccgaaga cgcgatggtg aggagcgggg
     1681 tcgtctcggt gccgcattcg gggcacgggc ggggcatggg gtcggtgagg ccccagcggg
     1741 tccagccgcc ggtcttccac ccgggcgcgt ggcacaggtt gcggaagtag aactcctgcg
     1801 ggtccatcgc gccggtgctg tcccatgcga atccggctgt ctcccaccgg ctcacgtcgc
     1861 ccaactgctg ctgcagttcc ttgctcagct ccatggggct ggggtagtcg gtgacctgtt
     1921 ccggtgcgag caggcacggt tccgggaggt accagtcgaa ctggatcacg ggcggctcgg
     1981 gcggggcatc gacgacgtcg gtgacggagg cggaggaacg ccagaagagg gcggttcggg
     2041 ggtgtgcaaa ctccgagtgg tcgcaagggc accacaggac ctggagaagg tcggctccgg
     2101 gagggctgac cgggagaggg acgtcgcggg tgtagagctg ggccacggga atcatgggaa
     2161 tcgggccgtc gaaccacggg tggccctcgc ggagccgctg ctcgatctcc cgttcctcgg
     2221 gcgtgatcgc gggtgcctgg ggggcgcgga gccgtcgctc ggccgctgct gcacggatgc
     2281 gacgcaggag ccggatgtcg tccgaagagt gcatctcgtc tgccgcttcc ctgtcgtgcg
     2341 gctcttcgca gtggggccac ggctcgtcgg cgggccacag gagcggcccg ccgacggagc
     2401 tgtcgtgcac ggacggagac ccgggccggg gatgcagccg ggtcgccgtg cgtgccagcg
     2461 gggcgagttg agggaagagc gcggtcacgt cgaacggccg cggcggggtg gtgaaactca
     2521 tgccggctcc cgatggcgcg aactgaactg tgatcagtta ccgaggttgt acaacccggt
     2581 gttcttcagg gtgttggtga catagacgtt ggagaacagc tcctcggtcg tcccgttcgc
     2641 ccgttcgata ttagcgttca tcgtgacgcc caccggaatg gtgcttttcg cgtccttgta
     2701 gacgggcgtc acctggtaga agatcgcgtc gttcgctccg aaattggcga ggggccctgg
     2761 atcatgttct gcgccttgga ctcgaacgtc cgcatgctgg gcgtgcccgt gttcatcccg
     2821 ctctgccggc aggggacgag gttggtccga gtgagcgcat cattgccccg tccgccgagg
     2881 atgctcgcga tgagatgaca ccgggacagg ccgtaggtga ggttgttcgc cgtcttgaac
     2941 gcctccgcgt ccttccagcc ggtgacggga ttgctggttc ccttcccccc gccggtcttc
     3001 cgccccaggc atgcctgcgc ctgggtgggt cgctctccgc ccccgcccgc cgggtcgctc
     3061 tggttgacga gaggaaccgc ctcggtggtg ttccagaacc agccgtcgcc gttgggaatc
     3121 gagttgaccg gtggggggtc gttcagacag ctggcgtgcg ggccggtgtc cggcaacgag
     3181 aacgtcagct cgaactggtc ggcgtcgatc acccgctgat ccttgaagcc gttggcgagc
     3241 tgcgtgtcgg cgaactgctt ctcgtcgagc gtgacatggg cctgcacgca gggtgaggcg
     3301 gggtccacga cacgggcgtc gttcaggatg taggtgtccc attcgccgtt gccgagattg
     3361 gggatcacct cgacgcactg cgcgccggcg gcaccgcctt ccttcgtggt gccccctgca
     3421 gcgcaacgtg gcgtgcgtga gccgacccaa cgcagagccc gatggtgtgg atcaggcgtc
     3481 ttcctcgtcc agcgccatca gcacctcagg aggaagcgtc ggcccgtgcg atacggacac
     3541 cgtggtcatc atcggcggag tgttggcctt ccgcagggcg gccatctggc ggcgaccgtc
     3601 agacaaatgc cacgcttcac cgcatcgtgt tctcccgtct gcgggtcgac ccgcgcactc
     3661 aggactacta cgagcgccgc atcaaggagg gcaagacccg acgtgaaatc gtccgctgcc
     3721 tcaaacgcta cgctgcccgg gaggtcttcc acctggtcaa acagctgcag ccagcacccc
     3781 gctcataggg gctgtcgtga cagatgaaag ggtcaggcgg gtgagtgaga caccgatgaa
     3841 caccctgcaa taccgctttg acgggccaga agacgcccct gtcctgatcc tcggtccctc
     3901 actgggtacc acatggcaca tgtcctagaa accgtcttca ggcgtccacg tggtctacat
     3961 cgctgctgtt catgcaggtg gggcctttgt ggtccaggcg catcgatggt gttggtgaca
     4021 gcaacgtgac acgtgatggg tcactggggc ccccgccggg caggtgctgg cagggggcct
     4081 cagcattcct gagcggcgag cgtccgctcc tcgatcctgc tgcggcgtct gcgaacgcct
     4141 ccttgagggc ccacaacggg cgccgccgcg tggccaccca ctcgacccga acgccagctc
     4201 gttggtgccc tgtcctacag ccgtcgagag gcgccgcact ggtggtgaag caacctgaac
     4261 caagatgtcg gtctctgtgc cgcggaatga tcggccggtg tcagatccag ggtgctccgg
     4321 gagctggcac tgagcatgct ctgtgtttct ggggggaggg gctgcgacgg gcgggagaat
     4381 gggtgggtgc tgtcccgggt ccgggcctga ctcctgacat ctctgaccaa tgtgtcccgg
     4441 tctcacagtg tcggccgttg gccggggatg gtgcgttgtc ggtgccgggc cggcggagcg
     4501 tgtcccgata ggggcctgcc gttcgttgcg gcgtcctcac gagtaccggc aacgcgacgc
     4561 gccgtcggac cggaagggga acgggcatgt ccagtacatc gaccatgtcc tccagtacgt
     4621 cgcgtgctcc gcagcaccct cgtcgtcgcc ctgcagggga ggtggttttg ggagtggaca
     4681 cgcaccgcga cgctcatgtg gctgcggtgc tctccgggac agggaccgtg ctggccaccg
     4741 gcgagttcac ggccaccgcg gcgggatacc gcgccacatc gctgtcgccg gacacctgcc
     4801 ccccgtgctg atgcgcgcgg gcgagccgcc cgaactgctc gatctgccta ccggcgcagc
     4861 cctcggggtc ggcggtgtcg ccttcgaagt caccaccttc ggcctggccc ccggcgacca
     4921 actggtcctc tacaccgacg gcttggtcga gacccgccac cacgccatcg acgagcgcct
     4981 ggacctcctc ctccaactgc tccacagacc cgaccgatcc tcggaagaaa cctgcgaccg
     5041 gctcctggac acactgcgcg atccggacga ccacgacgac gtcgccgtac tcatcgcccg
     5101 agctcgacgc tggccccggc ctaagagggc ggccagccgt gccgaagacg tcgcaatgct
     5161 gtaggccacg gccacggccg cggccaaggc cagagcgagt agcagcccgg aaccggcggc
     5221 accggcggcc gggtcgagcg cggcgaagat cccagccccg atcacggagc ctaggccgat
     5281 caacactgcg tcagatacgc cgacgcggcg cttcatcgcg cccgccccgc cggggctccc
     5341 actgtgtcgc ccactccttc tcgcacgggt cgttgatctc ggggcacggt agcggagcaa
     5401 ggtgtctggc cggggcggag ggcgtcagcg cttgctgtga cccgagacat gtcagtaggc
     5461 cgaccactga acatgccgat gtcgctcgac acgaccagga gctgaaccca aggcccgaac
     5521 cccgcacgcc caccggtaac agccttgagt tcccgatgag agaccctcgg aaatcctgaa
     5581 cacatggatc tttcgggacc aaggccccgc cattcgcgct gggcgatggc cggcgctgaa
     5641 aaccacggcg gtcccgatgg cgtggacagt gcgcccggcg acggagccga acacggcacg
     5701 gcagggagcc tgtccgtccg ccttccgagt cggccgtgtt cctaggatgc ggtggccctg
     5761 gctttcgggg cgggtgcaca caggcggcgg gcggcttcga cgatgacggc ccggtgctcg
     5821 gccagccgtt ccggccggta ggggtcggcg ccgtcgacag ccgtgaggag atctcgcggc
     5881 gcgagaaccc agctctgcgt gagcccggtg atgaggacga gcaggtctgt cgacggcagc
     5941 tgcccggcgg tcgagtccgc ggtcatgcgg gccatcttct cgctgtacac gtccgccgcg
     6001 tcggggccca gctcaggccg ttccatctgg cgccacagat gcatgcgcag cgcggcaggg
     6061 cgttgagtca agtagtcgaa catgcggccc gcgtatcccg gcagatcgtc ctcggtgagc
     6121 ggcaccgcat cgttcagttc gctgatgacc ttgtgcaggg cggcggcgaa caagagctct
     6181 ttgttggtgt agtacacgta aatggaccgc ttgttggcgt ccgcggcctc ggcgatgcgc
     6241 tcgatgcgag caccggcgaa gccgtaggtg ctgaactcct cgattgccgc cccgaggatc
     6301 tttgcgcggg ttgctgcgga gtcgtagggc atggcaccag cctaaggtaa ccaaccgttt
     6361 attgacaaat ctcggacccc gtgcctagat ggtaaatatc cagttatttt cattactggc
     6421 cgtaacggaa ggtatgccat gagtacgtcc acgtcctctt cgcccgtgtt cgagcgggac
     6481 ctgttcatca acaacacctg gcgccccggc tcctcgggcg agcgcgttcc ggtcgtcgac
     6541 cccgcgaccg agaaggagat cggatcagct gccgcggcgg ccttcgagga catcgacgcg
     6601 gccgtcgacg cggcccgtac cgcgttcgac tccggtccgt ggccgcgact gaccctgcag
     6661 gagcgcgccg agatcctgac gaggttcgcc gaggaactgg agaaggacgt cgatccggtc
     6721 accgaggtgc tggtcgccga gaccggcctg acggtcgggc agagccgcgg cggggccctg
     6781 accatgcccg gcctgctgcg ctactacgcc tccctggcgg acacgacgga gctgaccgaa
     6841 ctgcgcaccg gcctgtcggg ggtcagcgcc cgcatcgaga agcggccggt gggcgtcgtg
     6901 gcggccatcg tcccgtggaa cgccccgctc gcgctcgccg cgttcaagct tccgcaagcc
     6961 ctgctggctg gctgcaccgt catcatgaag ccgtcggagg acactcccct gagcgcgggc
     7021 tacttcgccg acgccgcgct gcgggcaggg ctgcacgccg gtgtactgaa catcgtcaac
     7081 gccctacccg cgggcggcga ctacttggtg cgccacccag gcgtcgacaa gatcaccttc
     7141 accggcagca ccgtggtcgg gcgtcgcatc gccgccgctg ccgccgacac cctcaagcag
     7201 ctcacgctgg aactcggagg gaagtccccg gcactcgtgc tggacgacgc cgatctggac
     7261 cgcatcgtgg agaccctggt gccgggggtc accgggaaca acggggaaag ctgcaccaat
     7321 cccagcaggc tcatcgtgcc cgagcaccgt cacgacgaga tcgtcggtgc cctcgccgag
     7381 gcgttcgcca agctgaccgt cggtgatccc cgcgacccgt ccaccgacgt gggggcaatg
     7441 gtcacccgca agcactacga gcgggtcctg gactacctcg cctccgcgga ggaggaaggc
     7501 ggaaccttcg ccgtcggcgg cggccgggcc cccggccacg acgtcggcta ctacgtcgcc
     7561 cccacgatca tcaccggtgt gtcaccggac gccaaggtcg cacaggagga gatcttcggt
     7621 cccgtcctga ccgtcctgac ctaccgggac gaggacgagg ccatccgcat cgccaaccac
     7681 accgagttcg gcctgtccgg cgccgtctac agcaccgaca ccgagcgcgc cctgcgcgtg
     7741 gcccagcaga tccacgccgg caccgtgaac ctgaacaacg gcatcaccgt cgacatcggc
     7801 gtgccgttcg gcggcgtcaa gcagtccggc tacggccgcg aactcggccc cgagggcctg
     7861 gacgccttct tcaacacgca cgtcatcttc ctcaacggag aacccctgcg cgtgatcaag
     7921 ggctagcagc agcacggtcc ggtccggtcc gccacggcgg accggaccgg accgttcacc
     7981 tcccaccgcg cagacgtcac ccacttggac aacagtcatg cgaatcgcca ctccgttcac
     8041 cgcctcaagc accgccatgg acgtcatcgc cggcgtcgac ctcaccggca gagcaatgat
     8101 cgtcaccggc gcctcctcag gcatcggcgt cgaaagcgct cgcgccctcg cggccggcgg
     8161 agctcacctc actctcgccg ttcgcgacct ggacgccgga cagcgcactg ccgacgacat
     8221 cgcagccacc accggcaacg accgcgtcag cgtccgcaga ctcgacctca ccgacctgga
     8281 ctccatcgac gcattcgctg ccggatggaa cggcccgctg cacgccctca tccacaacgc
     8341 cggcgtcatg gagacaccgc agaggtacac ccgctacggc tgggaactcc agttcgccac
     8401 caaccatctg gggcacttcg ctctgaccct ggccctccat gacgccctcg ccgaagcggc
     8461 gacgaccacc ggcgaggcac gcatcgtcgc cgtcagctcc agcggccacg gcagctcacc
     8521 cgtccgcttc gacgacctgt tcttccgccg ccgcccctat gaccccgggc acgcctacgg
     8581 acagtccaag accgcccaga tcctcttcgc cgtggaagcc acccgccgct gggcccagca
     8641 cggcatcacc accaacgccc tgatgcccgg cggtatctgg accaacctgc aacggcactg
     8701 ggatccggac cggcgcgcgc ggctcaaggc cgccatcccc ggcaagacac cccagcaggg
     8761 agccgccacc agcgtgctcc tggccgcctc cccccggctc caagacatca gcggccgcta
     8821 cttcgacgac tgcaacgaag ccgaacccgt cgaagaaatc atcgacggac tgcacggggt
     8881 acgcccatgg gccctcgaca aagacgccgc caggcgcctg tgggacgtct cactcgccct
     8941 catcgacgca gcccaatgat gacccgccac gcccacgagc cacccgaaac aggcttcccg
     9001 tccgcctcat ggcggcaggc caccgtctcc gccaccccgg ttgacgccaa cgccagggcc
     9061 gatgaagacc agatcatgcc cagccgcagc gccggagtgg acagacccgg gccgaacggg
     9121 cggacaaaga cgtagtagct cctgcgggaa caggctgacc ttgcgcggct gcccctgtac
     9181 caagaccatc gtcgttctgt cacccagtca acccgacctg cctgtcagga aggttggggc
     9241 cgtcggactg tacgaagcgg cgcagctcct ggcagacggg ttcaagaccg ggatcacccg
     9301 tgcgctacca ggagcttcat cgtgctggtc cacccgtccg cgattgatct ctcccgttcg
     9361 acccttcggt tcctgccccg gcgtcggtgc aggccgcgac cgctttgcgg atgaggacgt
     9421 ccgcgaccgc ctcctggaac gaggcggcgc cgtcggcaac cggcaggccg ccgtccgcgt
     9481 gccgacccac gctccccgag tggagccgtg aagatcacaa aatgtaccaa ctgtggtgca
     9541 gacttcgccc ctcacgtcgg gaagcctggt gtccggcgtg aggaggcagc cgatgcgttg
     9601 gatcgctgtg ggtgttggag gggtggctgc cctgggcgtt gcacggatgc tggtacggca
     9661 ggttcgagag ttgctggtgg acgtctgcga tgtcgtccgc gtgtggcgtg aggtgcggat
     9721 ggtcgtccgc ggctgccgac gtgctggtgc tgctcggtgc ccgagaccag ggcacacgca
     9781 gtgcggggat gctgtcgacg aagttcgtca ccgggctgct tccagctacg gccgcgctca
     9841 ggcggagtgt cggctgccct gctgtcctcg gccgggcagc cggtcggtca gtggcgttcc
     9901 gccgaggggg tctccacccg tgtgaaggag ttccggtggt tccccgaagc acctggtgcg
     9961 gcagccgtgt cttgcccttc gagcccggtc gggtgctggt tcacgcgtag tgggtgaggg
    10021 cgcggagaac gaagatgtcg gtgaggacgg ggatggtgta gcgcaggggg cggggggcgg
    10081 cttggtcgga gggtgatgtg tatccgccgt cggggttctg ttcgcccaga aggtagtgca
    10141 ggccgctgtg gacggtgggg tgggtgcggt gggtggaggc gagcgcggtg agggtgtagg
    10201 cggtgctcat cgggtcgctg tcctcccctg gggtctggcc ccagccgccg tcagggttgg
    10261 cggtgacgag caggcgcagg tggatggagt cgatggccgg gcccaggcgt ccttgatggc
    10321 ttgaggggtt gtggcggtgg gcgagcgtga gggcgttcag ggcgcggagc atggcgttgg
    10381 cttcgctcag gctccagctg cgttcgaaag ttccgtccgg tttctgggcg ttgaggaggt
    10441 aggcggttgc ccgttccagc agggggacgt gggcgaagtg atagggctgc agggcggtga
    10501 tggtattggc ggtcatggtc ggctcggagg gctgaccggg cagataggtg ggcatcccgc
    10561 cgtcctcgcc caggtacgcc gccaggaact gccgggcggc gtggatgtgt gcccggtacc
    10621 gctcggggcc gagggcgtgc aggaaggaca ggacgtgggt ggtggtgtcc gtgtcggtct
    10681 gtacgacgtc ctgggcgtag gcccagccgc cattgccggc ctgctgcgcg gcgaggtagt
    10741 cgcccatcgc gagcagcact tgccggtcgg cgccggcgcg ggccagagcg aggcccgcgg
    10801 tggcggtgca gaagatctcc tcgctgatga tgaacggcat gccgccgtcg ttgcgtacgg
    10861 ctttggccag cgcggtgatg ccgtcgtgga tgacccggtg tcctggcact gtccgctgca
    10921 gcgacagcag ggcgaacagg tgggcgaaca cgttgccctc gatgatcccc tggtcctggc
    10981 cgcgttcggt cagccgcagc agtcgtgcgg tcagttgcgg ggcgaccggg tcgggtacgt
    11041 gcaggtggtg gatggcgatt tgccgcaggc gggtccaggt ggcttcgttg tggtgctcga
    11101 acgcgtgcga ggggacgtcg acgtggaagg gctcggggcc cacgacggcg aggatcgctt
    11161 ccagggcgag cttcttgcgg tcggaggagt gctgggcggc accgtcgaag gtctgctcga
    11221 tgagccggtg ccggtcgctt gcgggaatgc cgtccagggt ggcatcgatg actgctgcat
    11281 cgaaggcgtc tgcagccgca cggctgcgcg acaggtaggc gtgcagcctg ctctgcaccc
    11341 cggacagagc cttctgacgg cgcagcaggg tcagcatcag ggccgactcg gtgacccggc
    11401 tgctgcactc gcccgtgacg gctccctgtc cgccgacctg ggcgagcagc cgctcggtca
    11461 gcagccgagt caccctgctc accgatgccg ggagcgccgc gcggtgggcc gaccgcatgt
    11521 cgcgggccgg ggctggtggg gagacgggca gggcggcctg gtcgcgcaga tacgtgagca
    11581 ggctggtgcg gtcacacacg ggccatgagt ggtggcgggc cagcgcccta agagcgggcg
    11641 acggctcgaa cgccacgggc cggccgaccc ggctcagcga cgagacgtca cccagggagt
    11701 tgcccaccgc cagcgaaccc gaccagtcga ttcgcccggc gcccaccagg tcctgcgcgg
    11761 ccctgtcctt cccgtcggcg accggtgcgg cgacccggcc ggtgaacagc ccgtcagccg
    11821 cctcgaactg cgtcccccgg aacagggtta cgcccagctc gcaggcaagg tacgccacca
    11881 tctcctgcgg gccacccgag atcagcaggg gcacatagcc ggcttccttc agcgccgcgg
    11941 tcagcggcct ggtgaagttg aacagccggt tgcgttgccg ctgccacagc cgggccgtca
    12001 ccgcggacac cgcccggcat ggcacatcgg tcagcatcgc ggcgaacaac tcgttcatcc
    12061 gcgccgccgc ctgcgggtcc tccgcatccg aggtcacctg cgcccggcgc agccgcgcca
    12121 gccggtcccg gggaacgagc ccagcctcgg caagcatcgt cggcagcgga ccggccagcg
    12181 tgcccgcaat cagcgtcccg tccacatcca acaccgcgat acgcatcctc cgagcctcgc
    12241 gcgcacgcca ccgcatccac gccggttccc cgccctgtca cccgatcgaa gacaccagcg
    12301 ccacgtcgac ctcccctgcc tgcaacgcgc cgcagcgggg cctcgactta ttcggcgggc
    12361 tcgatccaac ccagcagcat tcacgcgtcc gccgccgtga ccgacgatcc ggtgcagccg
    12421 ctcatctcaa acctcagtgg cgactggtcc gacgctgcgg gcccgtcgca cgccgagtcg
    12481 gcggcccatc cgcgctagcg ggcgagggcg tgtgcgtgtg cctcgtcgag cagttcccgc
    12541 agcgttgagg tggtgggtgc gacggctgtg gcgagcagtg ccgggccgtt ggccagcggt
    12601 gcgaggacgg cgcacccgtc cttggcgcct tcgccgagca gcacggggtc tcgtcggacg
    12661 tcgaggcgcg ggtccacgac caggagctgg ccgacggcgc ggtgcccgtt caggacggcc
    12721 gggccgttcc agccgggttc tggggccccg tacgccgtgt gctggtcgag tagcgggcgc
    12781 ccgccgcggt ggaccaggat ccgggtgacg aggtggccgg gttcctcgtc ggcccggccc
    12841 aggagttgct cttctcgcag tacaaaccgt gaggtggcgg cgagttcgac ggtgtaggtc
    12901 tggcgcaggt tgctgccggc ggcgctgatc aggggccgtg gtagccagcg cagatgcgcg
    12961 tgttctccgg cggtgaggcg cacgtcgtag gtggccgcgt cggtggtggg gccacgcagg
    13021 gcgagtgtgg cggcggccgt ggtgacctcc agctctgccc ggtcctcggc ggtgatgtcg
    13081 agggtgagcc ggtcgccacc gagcggggcg ctcatcgcgc cgatgatccc caccgtggcg
    13141 gcgttaccgt cggtgcgcag gcgtcgaagg tgaaaggggc cgtcgctgcg cagttgcggg
    13201 agggtggtga cgcgtccgtt gtgcgcggcg cggatccggg ccgtggctcg cacgccgtcg
    13261 gggtgtccgg cgggctcctg agcgccggct ggaggtttgc cgaggctgga cgtggctcgg
    13321 gctgcggcga gttgggacga ggggctcata cggtggcccc ggcgcgccac tgggtgaggt
    13381 ggccggtgac ccagtcggcg acttcgccga tgccgtcgtc ggaggtgaga ctggtgaaga
    13441 tgacgggaag atcgccgcgc tgtcgtttcg cgtcgctggc catggtgtcc aggtcggcgc
    13501 cgacgtgcgg ggcgaggtcg gtcttgttga cgaggaggag gtcggcggtg gtgatgccgg
    13561 ggccgccctt gcgggggatg tcgtcgccgc tggctacgtc gatgacgaag atctgcacgt
    13621 cgacgaggcc cttggagaag gtggcggtca ggttgtcgcc accggactcg acgagcacga
    13681 ggtcgagggg gtggagggtt gcttccaggt gttcgacggc ttccaggttt gcggagatgt
    13741 cgtcgcggat cgcggtgtgc gggcaggcgc cggtctcgac ggcggtgatg cgctcgggcg
    13801 gcaggacggc ttcgcgcagc aggtactcgg cgtcctcgcg ggtgtagatg tcgttggtga
    13861 cagcggcgat gcaccagcgg tcgcgcaggg tgcggcagag cgcggcgacg gtcgcggtct
    13921 tgccggagcc gacggggccg cccagtccga cgcgcagagc gcggcggctg ccgtcgggcc
    13981 gggtcgccga agcgctggag gcgtgctggt gaggcagaga gtggtcgagg tgcatggcaa
    14041 ctccgtttgg cggccttggt gttcaggtgt tggtcaggag gcgaagagcc ggacggacca
    14101 ggcggcgtgc tgctccccgg tgatgtccag caggggggag gaggccgacg gaagggcgtc
    14161 gaggccctcg gtcacggcgc gggtcgcggc gccggccgcg gcttgtgcga cgtcgtcggt
    14221 ttcggggccg aggcgggcca gcagccccga ggcgtcgagc gggtcgaggc tcagcaggcg
    14281 caccgctgcg gtggccgggc cgccgatgtt ctcgtacgcg gcggcatagg cggcgtccag
    14341 tggggcgagc ccggcggcgt gggcggcgag gcccaggacg atgggctggt gggcgccctg
    14401 gggacgggcg gcggccaggt ggtcgagttc ggcggacggg aaggtggcgc gggctgcgcg
    14461 catcatctgc cggccgagtc tgcgggcgac ggcacgtagt gcgggggcgg gggtgcgtgc
    14521 gtcggcggcg ttgtcgagaa gcagcgggtc gtatccgccg gcggctgcgg cggccagggc
    14581 ggccatcgtc aaggcggtgg tgtgcaggcg cccgcggcag aacgcctcca ggctgtgggt
    14641 gtcgtgtacg gctccgtggg cgacggcggc ctcgacgccg ccggagtggg cgtgcccacc
    14701 ggcggggaag cggccgtcgg ccaggaggag cagggctgcg cggctcatgg gcgagcggct
    14761 gcctttcaca gggtcggatg gtgatgcggt ggaccaggcg ggcgcatcag cccgccccgg
    14821 ggcccggccg tggccgcggg ccggcggccg ggcaggtgtc tgatcagaag aggaagtacc
    14881 gctgtgccag ggggacttcg gtgacgtagg agcgcggtac ggtcgcaccg ttgagttcgg
    14941 tgcgggcgtc gctcgtcgtc gcgccgccga tggtgacctc gaagctgttg tggtcgactt
    15001 cgaggctgag acgccacgtg tcgttgagtt tcatgtcgtc tttcttgacg ccccgggtgt
    15061 ccgtgatctc gacgaacttc tttttgagtc cgagcccctg cgtcttcgcg tctgtgacct
    15121 tgttgctgct gtcctgggtg atgacgaaac gggtgttcag cctgtcggcc acgccggggg
    15181 cggcgaagtt caccgagttg ctccctgggg agaggccggt ggaaccccac accggccgcg
    15241 gcaggtaggg ctgcggcgtt gtgatggagg cgttggcgtc gccgacctgg gcgtaggcga
    15301 gctggccgcc cttgaggacc atgtgcgtct tgacgccgaa gaacttcggc tcccacagca
    15361 ccaggtctgc cagcttctcc ggctccacgg aaccgacgta tttgtcgatg ccgtgagtga
    15421 tcgccgggtt gaccgtgtac ttggcgacgt accggcgcgc ccggtagttg tcgttcggct
    15481 tcagcctgtc ctcattgaag gagtggtcct tttcgtcatc cttgatcgtg cggactttcg
    15541 cgctctgcag gtcttcgggc agcgggccat agcggcactt catgacgtgc gcggtctgcc
    15601 aggtccgcat gatcatctcg ccgatgcggc ccatcgcctg ggcgtccgag gacatcatcg
    15661 agatcgcgcc catgtcatgc aggaggtcct ccgccgccat ggtggacggg cggatacggg
    15721 aatccgcgaa ggccatgtcc gccggaatgt ccgggttgag gtggtggcac acgaccatca
    15781 tgtcgacgtg ctccttgacg gtgttcaccg tgaagggccg ggtgggattg gtcgaggcgg
    15841 gcaggacgtt cggctccttg accaactcga tcatgtccgg ggcgtggccc cctccggcac
    15901 cctcgacatg gaagatgtgg atcgaacgct tcttgaaggc agccttggtg ctctccagga
    15961 aaccggactc gttgagcgag tcggcgtgca gggcgagctg gacctttcgg tcctcgcaga
    16021 ccttcaacgc caagtcgatc accgcagggg tggcgcccca gtcttcgtga atcttgaagc
    16081 cgatgacacc ggcgtccacc tgctcgttca gagcctcttt gttcatcgtg ctgcccttgc
    16141 cgagcagacc gatattgacc gggtactcgt ccagggcctc gaagactcgg gtgatgtgcc
    16201 acgcgcccgg ggtcacggtg gtggccgtgc tgccctcggc cgggccggtg ccgccgccga
    16261 tgagagtggt cacgcccgag gccagggcct cgtggatctc ctcggggcag atgaagtgaa
    16321 cgtgggtgtc cacaccgccc gcggtgagga tccggccgtt gccggagatg acctcggtgc
    16381 tcggcccgac cacgaagttc gtcgccgtca ccggtagctg ctcgcccgcc tgttcacggg
    16441 cgggcttctc gaagtccgag atcgggtcca tcgtctcggg gttgtacgcc ttgccgatgg
    16501 cgtgaactct gccgtccctg atgccgacgt cggccttgat cacaccccac cagtcgacga
    16561 tcagcgcccc cgtgatgacc gtgtccacag gacggcgatc cttcttgccg cccccgtccc
    16621 tcgggatgtg ggacatgccc atcgactcgc ggatcacctt cccgccaccg aagatcatct
    16681 cattgccgct ggacttcggt ccgccgctcc agtcggcttc gatctcgatc gtgagatcgg
    16741 tgtcggcgag gcggacacgg tccttggtgg tgggcccgta cagagcggtg tagtccgccc
    16801 gcttcagcaa gttgctcggc cgctgccggc ccgtctgctc cggctggctg ctcatcggac
    16861 gatccccttg cgcagtccct ggatcttgcg ggtgtcgctc ttggcgtcgc cttcgatctt
    16921 caccagctca acgcagcact cgtctcctgg ttcgaaccgc acggacgtgc ccgcggcgat
    16981 gttgagccgt cgtcccttcg cctcagcgca cgtccatagc tcgtcatagg tcacgccccc
    17041 gccggagggg ttcacgacca ccttgaggcc ggggttgacc tcggcgaagt ggtagtgcga
    17101 gccgacctgg atgggacggt cggacgtgtt cctgaccttg atcgtcttct tgtcgctctg
    17161 caggagcctg ttgaacgcga ttgcctcgtg ccaggacgcg gcgtcctcgc acgcagcgca
    17221 acaggcggac gggtcggtgt cgtcgcaggc gaccgggcac tccgggctgc gcgccggctg
    17281 ggggtgctcg accttgcccg ggtagacctc gggttcctcc gtggcttccg ggagggggtc
    17341 gtggatcgtg accagcttgg tgccgtccgg gaaggtcgcc tccacctgga cgttcttgat
    17401 catctccggg acgccgtcca tcacgtcgtc acgtgtgagc acccgtcggc ccgagtccat
    17461 gatgtcgctg accgtcttgc cgtcgcgcgc cgcctcgaag acgtgaacgg ataacagggc
    17521 catcgtctcg gggtagttca gaagcagccc ccggtcgcgg cgctttcctg ccacgtcggc
    17581 cgccacgtgg atcagtaagc gctcctgctc atgcggagtc aaatgcacga tgactcgtct
    17641 ctgttggtcg gacggtgcgt gcggccgggc atgcccaggt cacggacacc gttagccccg
    17701 aaggcgacgg ccgctctccg atcatcagcg gggaagaacg gcgagacggc cgaacggcgg
    17761 ctgatctaca ccatctgatg aatccgcgga gtacgccgtt ttcaccccgc cggacaggag
    17821 aagcccggtc tcgaaattgc ggacgaattc tgtgcgttgg gtagcttcct gggcctcgca
    17881 ttttgaatgc gtcctgggcc ggagcgtttc ctcgccgcac gcactccggg tcgctcacca
    17941 ctccgctcgt gcgccggttt cacgccctga cggtgtgctt ccggtttccc ccaccctggg
    18001 cctgccgccg ggtcccgggg agggcctcgc gggtctcgac accatggggg gactgtgtcg
    18061 tttctgcctg agcctgcatg tgatgcccgg ccgcgagggg gcggggatgt gcaggtggtg
    18121 gtggtcggcg ccgggttctc cggcatcggt gctgccatcc ggctgcgcca ggagggctgg
    18181 cgtgaccttg tggtgctgga gaaggcgtcg cagctcgggg gaacctggcg ggagaacacc
    18241 tacccggggt gcgcctgtga cgtcccgttc tcgctgtact cctactcctt cacccccaac
    18301 ccgcggtgga gcaggatctt cgccgggcag cgggagatcc atgactacct gcgcacgacc
    18361 gcggaccgtt acggagtcgg tgaggtgctg cggtgcggcg tccgtgtcct ggaggcccgg
    18421 tgggaccaga acacggggcg ctggcttgtg cagaccaccg acggcaagta ccgcgccagg
    18481 gttctggtcc tggccaccgg accgtggcat gaaccacggc ggctcgatgc gccgggcctg
    18541 gacgagttcc ccgggccggt gttccacacc gctgaatggg accactccgt ggacctcacc
    18601 ggccgacggg tggccgtcgt cggcagtggc gcctccgctg tccaggtcgt cccggccgtc
    18661 caggaccggg cggcgaccgt acacctcttc cagcgcaccg cacagtggct gctgcccaag
    18721 cccgacctgc cggtttcccc ggccctcaac tggtgtttgg accgcattcc aggcatacgg
    18781 cgcaccctgc gggccggcca gtacggcctg caagagagca tcggctacgc tctgcgccac
    18841 ccacggctgg caggtcctct ccagactgcg gcccgggctc atctgcgtct cacggtccgt
    18901 gacccggagc tgcgccgggc gctgacgccc gaccaccgcc tgggctgcaa gcgtctgctg
    18961 acgtcgagca cgttctaccc ggccctggcc tagccccgtg tccacctcca tcccaccgct
    19021 ctgtcctccg tacgcggccg gcacctcatc ggtgccgacg gcaccgagat cgaggccgac
    19081 gtggtgatca ccgccaccgg cttccgagtc ggtgagctgc cgctggcccg cagtgtgcac
    19141 ggcacggcag gccggacgtt gcacgagacc tgggccgggg acggccctca ggcatacctc
    19201 ggcaccagcg tcactgggtt ccccaatctc tttctcctcc tgggccccaa cctcctttcc
    19261 ggctcaacct ccgccatcag cgttctcgaa gcccagctcg cctacctggg tgcggctttg
    19321 aggcacccgc gccgcgaagg ccacgcctcc atggacgtca gaccggctgt ccaggccgcc
    19381 tacaacactg cggtgcagga agcactgcgg accaccgtgt acaacgcggg tggctgctcc
    19441 agctactact tccactccag cgggcggaac accttctgct ggccctggtc caccggccgg
    19501 ctcacccgct ccctgaaccg cttcgatgcc gctgcctaca cctgccgcgc accatcgaca
    19561 cctgctcccg tgcctgcacc ccgggtggtg gcggaagaaa gcttcccggc ggatgaggaa
    19621 ggaatcacca catgacgcgc caacgtgcca ggcgacagcc gttgaacggc tcggctgtcc
    19681 ctggacctgg ctgatgatcg ggcggcctct cggctgtgac gcacgaccgc agctcagccg
    19741 cctgtgcgtg tccggacggc tctcctgatc ggtgggggcc aagtgcgggt ccggttggca
    19801 ggcggggtgg cagaagcgct tgccagcctc agagccctgc ccgcccggtt tggtgctggc
    19861 cctcgatgtc gttcagtcgg gaggggaatg cccatgacca gtttgctcac cgcttcagca
    19921 acgtgcccgc agccgttgac cgtgggggag gtgatcctcg gtgtggacac tcatcgggat
    19981 gttcatgtcg ccgctgtgct ctcctggccg ggtgcggtgc tcggcaccgc ggtctttgcc
    20041 gccaccgcgt cgggctaccg tctgcttctt gagtgggcgc gcgggctcgg gccggtgtcg
    20101 cgggccgggg tggaggggac cggcagccgg cgatagcacc ggcccggccg gcgtcgccct
    20161 tgaccggaac gcttccgccc tcgcggaaat ccttctgcac atcaacgacg atcaatgcac
    20221 ggctcacagc acgacccttc ctcacaggac agcggagaac cccgatctgg tcaggcgtgc
    20281 cgccggcagt cggtacgcgc acgtcgtggc gacccgcgac caccacgtcg accccggcag
    20341 ccacttctcg gagcatccgg acttcaagga ctcctttccc gtccactgcg tggtcggcag
    20401 cgacgggagt accttccacc ccgatttcgc gcccgtggtc tcccaggccg tcgacgaggt
    20461 cttcttcaaa ggagcgcact ccgcgtccaa aagcggcttc gagggctcgg cgcaggacgg
    20521 cacgctgctg gcgtcgtggc tgcgggcgcg cgaggtcacc gatgtcgacg tggtcggaat
    20581 cgccaccgac cactgcgtga aggccaccgc gctggacgga gttcgggcgg gcttttccgt
    20641 acgtgtcctg ctcggctata ccgccggtgt cgcggccgac agcaccgagg ccgccgtcac
    20701 cgaactgcgc cgcgcgggca tcgcactgac cggcaagccg gtcgtcctga cctgacttgg
    20761 cctcaaagga tgccccgggt ccgcgcaggc gcgagcgggc tgcccagggc tcacgggtag
    20821 ctgatccggc ctgtgacgct tgctggccac agcgggtgat gccggcgcgt ggccagtgat
    20881 gcgtgagccc ggtccggtcg caagtcggac ctggccacgg cggcgctcgg caccggccgg
    20941 ccgtcttgag ctgtactgag atttgtggag tccccggact gccccgagtt gggtggagtc
    21001 ggcgaggatg tccagggcgc cggtttcctc ctgcagcagg tccgcggcga ctgcggcttc
    21061 gtgatgttct gctcctgcgg ccggccgcag ggtgatggcg gtgatcaggc cggtctccgg
    21121 ctcgacggcg aggtgggctt tgaacccgtc ctggcggtgt gagcgcgcct tgtgcacgtg
    21181 ccgggcttgg ggggcgacgg tggagaccat ccggtcgggt gcggtgtgtc gggcgaggcg
    21241 ccagcggccg tcggtgccgt cggaatcgtc ggccggctcc acgtcctgcc cggcgaccag
    21301 ggccaggatc cccgcggcct cggccgcctt gggccccagg tcctgctgag gcagatgccc
    21361 cagcagcaac aaagcgtccg tgaccaacgc ggcgaccaga gtgttgcggg cctgttcgtc
    21421 gttccaggag atcttcggct tgcccgggtc ggcgtagtcg tgggcccggc agtgttcagc
    21481 ggccacccgt tcagcgccgg gaacctcgcg gatcacccgg cggatcgcgg cgaccagctg
    21541 agtgacagtg tcctgggtgg ctaccgcatc gtccagcacg gctgagtcca gcgcccgccg
    21601 gtgcctgccc ttgagcgcgc cggtggcctc caccacctca cgcacggcgt cgaagagccg
    21661 aaccggacgg cgagagcgag ccagccgacg ccggaagtag gccagcaacg agggatcaaa
    21721 cgggcggtcg tgcgggccca gcccgcacgc ggccttccac ctcagatcac accgcaggtg
    21781 ctggacagcc tcgaagcccg acagaccatg cagggtctgc agcacgatcg tgcatccagt
    21841 tcgcccggag gcaccgacgg gcggccgtcc gaggacggat acatgtccgt gaacatcgcc
    21901 tccgggaaca gcgcgtcccg gtgctcggcc aggaacgcga acacgctccc ggtgggaatc
    21961 aactccggca cacccacaca tcaggcccga ccggacgact gcgcggccgt cccatcatgc
    22021 ctacaactct gaccccacac cgcatgatcc agggccagaa cagcccaaca ccttcactgg
    22081 tcctcctgcg tgacggaaac gctggggcgt cgccgtcgcc ttcgggcttg ttggagtcgt
    22141 cccccgggga ggcgcagaga atcgggtaga tcggccggcc gtcacggcgg tgcacaaccg
    22201 gtgcgagcgg gttgggggaa gcgagg
//
