LOCUS       NZ_BMUQ01000014        21886 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces mirabilis strain JCM 4551 sequence14, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUQ01000014
VERSION     NZ_BMUQ01000014.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces mirabilis
  ORGANISM  Streptomyces mirabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 272786)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 117X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650275.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:52:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,311
            Genes (coding)                    :: 9,898
            CDSs (with protein)               :: 9,898
            Genes (RNA)                       :: 81
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 414
            CDSs (without protein)            :: 413
            Pseudo Genes (ambiguous residues) :: 0 of 414
            Pseudo Genes (frameshifted)       :: 172 of 414
            Pseudo Genes (incomplete)         :: 329 of 414
            Pseudo Genes (internal stop)      :: 40 of 414
            Pseudo Genes (multiple problems)  :: 115 of 414
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 78314
            Orig. end                         :: 100200
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUQ01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21886
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /product="melanin"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..21886
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /detection_rules="melC"
                     /kind="neighbouring"
                     /product="terpene-precursor"
                     /product="melanin"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21056
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21056
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11056](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11056)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(242..256)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.12"
                     /tool="antismash"
     misc_feature    874..885
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            complement(962..2461)
                     /locus_tag="IE289_RS30585"
                     /old_locus_tag="GCM10010317_063070"
     CDS             complement(962..2461)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537361.1"
                     /locus_tag="IE289_RS30585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063070"
                     /product="sugar transferase"
                     /protein_id="WP_190172042.1"
                     /sec_met_domain="Bac_transf (E-value: 1.3e-67, bitscore:
                     220.7, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQGGLVGPFPSARGRLANGAISEPAIEWEQRYRRAVITSDTVAT
                     AFVVAGIGNFFGARDAANWHEKWGILAFGTQLLVLGALAVSRSWAPAVLGQGAEEFRRL
                     GRSLFTATVVLALGGIALTSRNIKLWIFVAVPAIALVTMTERYLLRLWLHKQRKEGRCL
                     RPVLAAGSPATVRDLINRTRKFPHLGWRVEAVCTTDGRGLDGDQGGLDGDQLDGVPVIG
                     LLEDVAKHVRHDGYRVVAVTPDPHWSPDRLQRLAWNLEGSDAEMIVAPVLMEVAGPRLH
                     VDAVLGIPLLRVSMPTFTGGRRAIKGVVDRMGAAILLVLFAPLMVLVGLLVLMDSRGGV
                     FYRQRRVGKDGREFTMLKFRTMVAGAHKARAELADRNEGAGLLFKLRRDPRVTRVGAVL
                     RRYSIDELPQLFNVLTGAMSLVGPRPPLPEECAAYDPDIRRRLLVKPGLTGLWQISGRS
                     DLPWEEAVRLDLRYVEDWSLALDTVILWKTLRAVLHGQGAY"
     misc_feature    complement(2977..2992)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(3214..3229)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.42"
                     /tool="antismash"
     gene            3273..>4354
                     /locus_tag="IE289_RS30590"
                     /old_locus_tag="GCM10010317_063080"
                     /pseudo=""
     CDS             3273..>4354
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474440.1"
                     /locus_tag="IE289_RS30590"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GCM10010317_063080"
                     /product="IS110 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIYRGIDWAERTHDVALVDDTGSLLAKRHITDDAAGYTLLLELLA
                     EHDDFGKDPIPVAIETSRGMLAAVLRTGKRQVFAINPMAAARYRDRHSVSRRKPDPGDD
                     LALANIVRTDMHAHRPLPQDSDPARAVAVLARAQQDATWNRRQIANQLRSLLGQYDPAA
                     LEAFAPWANGLCRPEARELFKTAPTPARAARLTRTQLQSALKRAGRRRGTAAEADRLRD
                     VFRSNWKPPAPPPTSSPTRWKWRSLNTRTPRCC"
     misc_feature    complement(4409..4424)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.82"
                     /tool="antismash"
     misc_feature    complement(4465..4479)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 26.03"
                     /tool="antismash"
     misc_feature    4466..4480
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.16"
                     /tool="antismash"
     gene            4583..5746
                     /locus_tag="IE289_RS30595"
                     /old_locus_tag="GCM10010317_063100"
     CDS             4583..5746
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015663064.1"
                     /locus_tag="IE289_RS30595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063100"
                     /product="glycoside hydrolase family 64 protein"
                     /protein_id="WP_229889283.1"
                     /transl_table=11
                     /translation="MAAATVTTALLTFGAPSDANAAVPTTIPLKFTNNSGRSEPVYIYD
                     LGTLLSTGQQGWADANGAFHAWPAGGNPPTPAPDASITGPANGQSMTIRMPKFSGRIYF
                     SYGQKLDFRLTTGGLVQPAVQNPSDPNHNILFNWSEYTLNDSGLWINSTQVDMFSAPYA
                     VGVQLADGSTKNTGHLKTGGYTGFFNALRGQPGGWANLIQTRSDGTVLRALAPGHGIEA
                     GALPGTVMDDYVNRVWQKYSSSTLTVTPFTDQPNTKYFGRVSGDVMNFTNSAGAVVTSF
                     QKPDSDSIFGCYKRLDAPNDLVRGPISRTLCAGFNRSTLLTNPNQPDTSSANFYQDTVT
                     NQYARKIHAQMADGKAYAFAFDDVGNYESLVHDGNPQQAYVTLDPFN"
     gene            complement(5761..6426)
                     /locus_tag="IE289_RS30600"
                     /old_locus_tag="GCM10010317_063110"
     CDS             complement(5761..6426)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994645.1"
                     /locus_tag="IE289_RS30600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063110"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190172044.1"
                     /transl_table=11
                     /translation="MSTPLPPFPRGQEPSGAPVPLELTVGPAAPQLRADAARNRARLLE
                     AATRLVEEHGVANVTMEAVAAAASVGKGTVFRRFGDRTGLLMALLDHTEQQFQAAFLSG
                     PPPLGPGAAPADRLHAFGCRVLREIHDRLDLYLAAEPDASRRFSSAPYRVRFTHVVMLL
                     REAVPGADSVLLAQTLMGYLEPALIHHLTRQCGMPLERLESGWHDLVKRTTCPVPDRP"
     gene            6555..7118
                     /locus_tag="IE289_RS30605"
                     /old_locus_tag="GCM10010317_063120"
     CDS             6555..7118
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191782.1"
                     /locus_tag="IE289_RS30605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063120"
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="WP_099924572.1"
                     /transl_table=11
                     /translation="MSVRILALVGSLRAGSHNRQLAEAAIKLAPEGAEIELFEGLAEVP
                     FYNEDLDVEGKVPAAAIALREAAGRADAFLLFSPEYNGTITAVLKNAIDWLSRPYGASA
                     FTGKPAAVVGTAFGQFGGVWAQDEARKALGIAGAAVLEDLKLSVPGSVTRFAETHPVDD
                     AEVAAQLTEVVARLHSQVGTASAS"
     gene            7252..7929
                     /locus_tag="IE289_RS30610"
                     /old_locus_tag="GCM10010317_063130"
     CDS             7252..7929
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433207.1"
                     /locus_tag="IE289_RS30610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063130"
                     /product="AIM24 family protein"
                     /protein_id="WP_099924571.1"
                     /transl_table=11
                     /translation="MKGDLFSSDHMVQPAVTPGMTIQNAKSIKYAVNGDMLARQGAMIA
                     YRGNLQFERKGQGVGGMLKRAVTGEGLPLMTVRGQGEAWFAHEAQNCFIIDIEPGDLFT
                     VNGRNVLCFDSTLSYEIKTVKGAGVTGGGIFNSVFSGHGSLGLICEGNPLVIPVSPQQP
                     VYVDTDAVVGWTAQLHTSLHRSQSIGSMIRGGSGEAVQLKLEGDGLVVVRPSEATPQKA
                     QQH"
     gene            complement(8023..9798)
                     /locus_tag="IE289_RS30615"
                     /old_locus_tag="GCM10010317_063140"
     CDS             complement(8023..9798)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982566.1"
                     /locus_tag="IE289_RS30615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063140"
                     /product="M4 family metallopeptidase"
                     /protein_id="WP_190172045.1"
                     /transl_table=11
                     /translation="MRRPHIRRVAIAVAVTTAATLPMGPAFAAPDSPARAATSASSPVE
                     AARAAAFAHASATGVGPGDTLRATDVMTDPDGKQHVRFVRSHQGLPVLGGDLVVHLGKQ
                     SAYLGVTRAADHAVKPATTEAKLTPQQAEQKAAAVAQGDAGSAELVVDARDGAAALAYQ
                     VRVTDSDTTEAGGSRTVVVDAQSGRIRSNTPDSDEFISPHLEKTLREKGETASPVTGVA
                     TQPAGLLGATAAARYPVKATGSGISLFAGKVTLTTTQTARTSFLLKDPTRWNTETRDAK
                     GAELEAFSRGTKFTSTTNKWGTGTTANRTTTAVDAQYGITQTLDFYKKTFGRKGIKNNS
                     TGARAMVHFGRKVGNAFWDSTCGCMLYGDGDGAMFKKPLVVLDVTGHELTHGVVDATAA
                     LEPTRVDARGNQYGEPGALNESLADIFGSNVEFSANNPKNPPNYLMGEKLGLAQKFLRR
                     LDHPSLDKLEGTIDYWSPAAYDTEVHAGSGVSSHAYYLLAEGSGRKTIGGVKYDSPTYD
                     GSRVTGIGRAKATAIFYRALTRYMVSTTDFHDARTATLKAAADMYGATSAEYLAVDAAW
                     AAVNVTTANTPAAGR"
     misc_feature    complement(9942..9957)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     gene            complement(10001..11056)
                     /locus_tag="IE289_RS30620"
                     /old_locus_tag="GCM10010317_063160"
     CDS             complement(10001..11056)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670760.1"
                     /locus_tag="IE289_RS30620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063160"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_190172046.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.8e-65, bitscore:
                     213.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPRTVLTAPPAAPEILARCRELVAPALAEAIDGLHPWVAEMAG
                     YALGRCEVGGAPATHRPGKGVRQALAVLGAEAAGGSAEAGVPGAVAVELLHTFSLLHDD
                     IMDGDALRRGRPAVWKAYGTGPAVLTGDALFALAVETLTAAPATSHAAAAVRRLTRASR
                     DLVRGQADDLLFAHRPWTGPDAVSAGEYEAMAEHKTGALLGCALALGAGLAGAPQETAA
                     ALDRAGRHLGVAFQIADDLLGIWGDPAVTGKPVHGDLRHGKKTLPVLAALAAPGRSPLA
                     ELLASTAVLDDGAVRRAATLVERAGGRTAALGAARRHLTAADTLLAGASLAPRPAADLR
                     TLLSSLAHRTI"
     gene            complement(11053..12111)
                     /locus_tag="IE289_RS30625"
                     /old_locus_tag="GCM10010317_063170"
     CDS             complement(11053..12111)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982568.1"
                     /locus_tag="IE289_RS30625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063170"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_190172168.1"
                     /transl_table=11
                     /translation="MYGKAFAPEYQGALTTLSVNSSLTDVLAAGTEQLRAAERVGARAE
                     AARSGLAVAEAHRRLGQVADADRAWKASYRTAREARDTGAMAWALWSGGTLARQRGAFP
                     LAWRLLRLAAELGKQSGDVVVRGYSLAGMAETGRIQGDYAAVTALHEQLLAEARKRGEA
                     RHTVWALEGIAQIHRNTGAYDTAYALFEEAAEIAARAEDRRGHAWALRGLADIISVRDR
                     DPDRALALLSEAEVSCRAMNLSGALAYNHKMRGNVLYRAGRYERARDLYAQALAEFETM
                     SEPRGRALSRLGLVKSLARLGRDHAETAAELTELARVLEGIGLRHAREMVERARTELGL
                     TPPEGADAEAAR"
     cand_cluster    11503..21886
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    11503..21886
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[16502:16886](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16503..16886
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="2"
     gene            12404..13288
                     /locus_tag="IE289_RS30630"
                     /old_locus_tag="GCM10010317_063180"
     CDS             12404..13288
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061349.1"
                     /locus_tag="IE289_RS30630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063180"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_190172169.1"
                     /sec_met_domain="APH (E-value: 2.8e-31, bitscore: 103.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPGEFPIDASLVRRLLAAQFPRWAELPLKHFPSAGTVNALYRLG
                     DDLAVRLPRIEGGAEDVAKEAHWVPRLAPLLPATLPEILATGTPGEGYPWPWMVQRWLD
                     GEPPRADRLTDPLPLAADLGAFVAALRRVRLPDGPTAYRGVPLSTADAMTRAALDELRG
                     TIDTSAATAAWEAALVAPAWTGPPTWVHSDLMPGNLLTRGGRLDAVLDFGTVGVGDPAC
                     DLIPAWNLLPAEARDTFRRAAGADDATWARGRGWALSMALIQLPYYRVTNPVIAANAEH
                     VIHAVLTEADARP"
     misc_feature    complement(13297..13311)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 21.74"
                     /tool="antismash"
     misc_feature    complement(13297..13312)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.41"
                     /tool="antismash"
     misc_feature    complement(13298..13311)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.35"
                     /tool="antismash"
     gene            13333..13959
                     /locus_tag="IE289_RS30635"
                     /old_locus_tag="GCM10010317_063190"
     CDS             13333..13959
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982569.1"
                     /locus_tag="IE289_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063190"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_097283181.1"
                     /transl_table=11
                     /translation="MSTHLQGSLFDQTDELHLSQLNAMRRTVLGDGAWIDLLPGWLSGA
                     DALFARLVDEVPWRAERRQMYEHVVDVPRLLAYYRAGDALPHPILDEARQALSAHYARE
                     LGEPFTTAGLCYYRDGRDSVAWHGDRIGRGAREDTMVAILSVGAPRDLLLRPRRGGETV
                     RRPLGHGDLIVMGGSCQRTWEHAIPKTARAAGPRISVQFRPDGVN"
     gene            complement(13999..14598)
                     /locus_tag="IE289_RS30640"
                     /old_locus_tag="GCM10010317_063200"
     CDS             complement(13999..14598)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987916.1"
                     /locus_tag="IE289_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063200"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_190172170.1"
                     /transl_table=11
                     /translation="MSTVSTPPPGLSATPIAPPRRDAEATKAAILRAARHLMARHAHAD
                     ITLKAIADRAGVSAPLILKYFGNKDALFGRVMSFETDAAALLAAPLDRLGPHMVRQVLV
                     GQTERGADPVLRIIFAPRQGDQGDIMRANFRTQVSDRLALRLSGPDADLRAELAVGTLL
                     GLGAMYGIARGTRLRATPIEDIVDRYGPTVQALLTP"
     gene            complement(14595..16040)
                     /locus_tag="IE289_RS30645"
                     /old_locus_tag="GCM10010317_063210"
     CDS             complement(14595..16040)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670769.1"
                     /locus_tag="IE289_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063210"
                     /product="MFS transporter"
                     /protein_id="WP_190172047.1"
                     /transl_table=11
                     /translation="MVALRDRLTVPVLALGGSLMAVMQVVVVPLLPDLPRLTGASAGAV
                     SWMVTATLLTGAVLNPVLGRAGDMYGKKKVLLIALGMMTVGSLMCALTSDIRILIAARA
                     LQGAAAAVVPLSISLLRDELPPERTGSAVALMSSTVGIGAALGLPIAAMVVQYASWHVM
                     FWGTTAVGALGTALAWWAVRESPVREPGRFDMTGALGLALGLSCLLLGVSQGGQWGWTS
                     PRILGLFVGSVCVLGLWWAQQLRAARPLVDLKLATSPRVALPHVAALLTGFAFYANSLV
                     TAQLVQAPKATGYGLELSIVATGLVLLPGGVIMLLLSPVSARISAARGARVTLALGTLV
                     IAAGYGIRIINSHSLLVILLGSAVCAMGTAFSYSALPTLILRAVPAGQTASANGVNVLM
                     RTVGQAVSSAAVAAILVHHTSLVGGAPIPTLHGYLLAFAMAGTVALVACVAALVIPADP
                     TLRDTRRASGSSDAPRDEAFEGA"
     misc_feature    complement(16068..16083)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            16503..16886
                     /locus_tag="IE289_RS30650"
                     /old_locus_tag="GCM10010317_063220"
     CDS             16503..16886
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005952.1"
                     /locus_tag="IE289_RS30650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063220"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_190172048.1"
                     /sec_met_domain="melC (E-value: 8.3e-50, bitscore: 162.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELTRRRALGAAAALAAAAGTQTVAVARAADTGHHGGPEAFDEV
                     YRGRRITGRAAAGGGHHHEHGAGYAVFIDGVELHVMQNADGSWISVVSHYDPVPTPRAA
                     ARAAVVELQGARLVPLGMPMPQQ"
     gene            16921..17745
                     /locus_tag="IE289_RS30655"
                     /old_locus_tag="GCM10010317_063230"
     CDS             16921..17745
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982575.1"
                     /locus_tag="IE289_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063230"
                     /product="tyrosinase family protein"
                     /protein_id="WP_075025915.1"
                     /transl_table=11
                     /translation="MTVRKNQANLTADEKRRFTDALLQLKRSGRYDAFVTTHNAFILGD
                     TDNGERTGHRSPSFLPWHRRFLLEFERALQSVDASVALPYWDWSTDRSPRSTLWAPDFL
                     GGTGRSLDGRVMDGPFAASAGNWPISVRVDGRTYLRRSLGSGARELPTRAEVDSVLGMA
                     TYDMAPWNSSSDGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAYIDKL
                     WADWQRRHPASGYLPLSGTPDVVDLDETMKPWNDVKPADLLDHTAFYTFDTV"
     gene            complement(17945..18664)
                     /locus_tag="IE289_RS30660"
                     /old_locus_tag="GCM10010317_063240"
     CDS             complement(17945..18664)
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009308694.1"
                     /locus_tag="IE289_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063240"
                     /product="ribonuclease H"
                     /protein_id="WP_099924562.1"
                     /transl_table=11
                     /translation="MIGDMLERVVAACDGASKGNPGPAGWAWVVADGAETPTRWEAGAL
                     GTATNNVAELTALERLLTAIAPDVPLEIRMDSQYAMKAVTTWLPGWKRKGWKTASGKPV
                     ANQELVARIDELLDGRTVEFRYVPAHQVDGDRLNDFADRAASQAAIAQQPAGSDLGSPE
                     PPPSPDTPAPSGAGRRRTTAAASAKTPRQGTSARTIKAKFPGRCLCGRSYAAGEPIAKN
                     GQGWGHPECRTAEPSNA"
     gene            complement(18645..19700)
                     /locus_tag="IE289_RS30665"
                     /old_locus_tag="GCM10010317_063250"
     CDS             complement(18645..19700)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852987.1"
                     /locus_tag="IE289_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063250"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190172049.1"
                     /transl_table=11
                     /translation="MLRIHFTSDDLQNIRVARQPDPLWELMCSVCRLETGQGPLEFGHW
                     RRSARQRFSGDSNLGRALRPLRALIPATGYIPDFLTPPVTGGGLSAGLDQLLRTPRVQL
                     VRELSRLAESRPVPSWAASLGRPGSDALKVLANSLGIYFRGLLEPHWPHIRTAVGNDVG
                     VRARALLDGGTQALLESLRPVARWSSPVLEVDYPVQRDLYLEGRGLLLVPSYFCWRRPT
                     ALADPGLDPVLVYPVAKTPLAVADGTDGGVERLLGRTRAAVLTEVAGQSARTTSEVAEA
                     VGIALPSASYQIGVLRDGGLVASHRDGKYVLHTATLLGLRLLGTSPRMRESVLLPVRGA
                     AAGPWHDRGHA"
     gene            complement(19877..20674)
                     /locus_tag="IE289_RS30670"
                     /old_locus_tag="GCM10010317_063260"
     CDS             complement(19877..20674)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031563.1"
                     /locus_tag="IE289_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063260"
                     /product="VOC family protein"
                     /protein_id="WP_190172050.1"
                     /transl_table=11
                     /translation="MAVQPEGTPCWADAMFSDVEGAKSFYGEVLGWTFGESSSEYGNYT
                     QAYANGKAVAAVVPPMPGQEGQSAWCLYLASPDAAATAQKIRAEGGEVLMEPMQVGDFG
                     TMVIARDPSGVVFGVWQPGRHEGFEARGVPGAYCWAEVFTREPEKSDTFFSAVFGYRMK
                     QLDDDAVDFRLYDLGEDPVLGRMRMTDDFPPEVPPYFNVYFTVEDCDAAVAKATERGAI
                     LRFGPMSSPFGRFAALSDPQGAAFSVIDVKTTEGAMPKATDVS"
     gene            20820..21836
                     /locus_tag="IE289_RS30675"
                     /old_locus_tag="GCM10010317_063270"
     CDS             20820..21836
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004024 - alcohol dehydrogenase (NAD+)
                     activity, zinc-dependent [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006113 - fermentation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009067430.1"
                     /locus_tag="IE289_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_063270"
                     /product="zinc-binding alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_190172171.1"
                     /sec_met_domain="ADH_N (E-value: 2.2e-31, bitscore: 101.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAWEVARPGPIEGEPLRFVERPIPVPGADELLVHVRACGVCRTD
                     LHVSEGDLPVRRPRVTPGHEVVGVVAAAGEDVLDHAVGDRVGVAWLRRTDGTCGYCARG
                     SENLCPASEYTGWDADGGYAEYTTVPAAFAYRLPGEVDDVALAPLLCAGIIGYRALLRA
                     ALPDAGRLGLYGFGGSAHLCAQLALAQGATVHVLTRDPAARRLALELGAASARGAYDEP
                     PEPLDSAILFAPVGDLVPVALRALDRGGILSVAGIHLSDTPPLRYESDLFYEKELRSVT
                     SNTRRDGRDFLALAARHGVRATTHVYPLSEAQRALRDLKAGRFDGAAVLVNDFPART"
ORIGIN
        1 gttggaggcc agcacatggg agaggatggg caccgagacg tcggcccgct gcgccgcgtg
       61 gaccaggctg cgcaggtcct tgggcaggca ggagccaccg aaggcgaagc cgggccgcag
      121 gtaggcgggg ctgatgttca acttgcggtc ggccaggaac acgtccatca cctggtgcga
      181 gtccaccccg agcgcctggc acaccgcgcc cagctcgttc gcgaagccga tcttgaggcc
      241 gtggaacgcg ttgtccgcgt acttgatcgc ctcggcggtc gggaccggca cccggaacac
      301 ctcgccgggc aggccgtcgt acagcgccgt caccgcgtcg ccgcttgccg ggtcgagctc
      361 gccgatgacg gtcttgggcg ggtcgaagaa gtcctgcacg ctcgtgccct cgcgcaggaa
      421 ctccgggttg accgcgaccc cgaagtccac cccggccgtg cctccgacgt tcttctccag
      481 gatcggcacc agcaggttca ggcaggtgcc cgggagcatg gtgctgcgga acacgacggt
      541 ctgccgcccg cctcgctcgg cgagcgcggc gccgatctgc tcggtgacgc gctccaagta
      601 cgtggtgcac aggctgccgt tgggctccga cggcgtgccc acgcagacca gcgatatctc
      661 gctgcccatg atcgcctcgt ggacgtcgcc ggtggcgcgc agcgctccgg tccgcacgac
      721 ctcggcgatg agctcgccga tacgttcctc caccaccggg gccttgccgt cgttgaccag
      781 gtcgaccttc acctggttca cgtccacccc gatgacctcg tgccccatgc tggccaggca
      841 cgcggccgac acgcagccca cgtagccgag cccgaaaacg ctgactctca tgacccgttc
      901 ctccccccag gcaggccctt gcggcctgcg gtccgcgcgc cggtcggacg atccccgcgc
      961 atcagtaggc cccctgcccg tggagcacgg cacgcagcgt cttccacaag atcactgtgt
     1021 ccagggcgag cgaccagtcc tccacgtacc gcaggtcgag gcggacggcc tcctcccacg
     1081 gcaggtcgct gcgtccgctg atctgccaca ggccggtgag cccgggcttg accagcagcc
     1141 gccgccggat gtccgggtcg tacgcggcgc actcctccgg cagcggaggc cgtggaccga
     1201 cgagcgacat cgctccggtg agcacgttga aaagctgcgg gagttcgtcg atcgagtacc
     1261 ggcgcagcac cgctcccacc cgggtcaccc gtggatcccg gcggagcttg aacagcaggc
     1321 ccgcaccctc gttgcggtcg gccagctccg cacgtgcctt gtgggcgccg gcgaccatgg
     1381 tgcggaactt gagcatggtg aactcgcggc cgtccttgcc gaccctgcgc tggcggtaga
     1441 acaccccgcc ccggctgtcc atcagcacga gcagccccac gaggaccatc agcggtgcga
     1501 acagcaccag caggatcgcc gcacccatcc ggtcgacgac ccccttgatc gcccggcggc
     1561 ctccggtgaa ggtcggcatg ctgacccgca gcagcgggat cccgagcacc gcgtcgacgt
     1621 gcagccgcgg gccggccacc tccatcagca cgggggccac gatcatctcg gcgtcgctgc
     1681 cctcgaggtt ccaggccagc cgctgcaggc ggtccggtga ccagtgcggg tcgggtgtga
     1741 ccgcgacgac ccggtagccg tcgtggcgga cgtgcttggc gacgtcctcc agcaggccga
     1801 tgaccggcac cccgtccaac tggtcaccgt cgagccctcc ttggtcgccg tcgagcccgc
     1861 gaccgtccgt cgtgcacacc gcctccacgc gccagccgag gtgcgggaac ttgcgggtcc
     1921 ggttgatcag gtcgcgcacg gtggccgggc tcccggcggc gagcaccggt ctcaggcatc
     1981 gtccttcctt gcgctgcttg tgcagccaca ggcggagcag ataccgctcg gtcatggtga
     2041 cgagcgcgat cgcggggacc gcgacgaaga tccagagttt gatgttgcgc gaggtcaggg
     2101 cgatcccgcc gagcgccagg acgacggtcg ccgtgaacag cgagcgtccg agccgacgga
     2161 attcctcggc accctggccg agcacggccg gagcccacga ccggctcacc gcaagcgctc
     2221 ccagcaccag cagttgggtg ccgaatgcga gaattcccca cttctcgtgc cagttggccg
     2281 cgtcccgggc cccgaagaag ttgccgatcc ccgccaccac gaaggcggtg gccacggtat
     2341 cgctggtgat cacggcacgg cggtaccgct gctcccattc gatcgctggc tcgctgattg
     2401 cgccgttcgc cagacgcccg cgcgccgacg gaaacgggcc gactagtccc ccttgccgca
     2461 cagaaccccc caaggtcccc agtggttcga cgtgttcgcc tcacactgtt tcgcccccct
     2521 gcgggaggcc cccgcctccc gccgtgctgt tcccccctcg ggaggccccc gccccccgcg
     2581 catgacatcc cggctttcag agttacgtgg acaacccacc ctggcggcag cagactcgca
     2641 cgtcctgcct ggctcctgag gtgcgcggga acccgtcgaa acctcggatg ctccccgcac
     2701 ccaaagcccc tctcgagctc caagaattga tcacccccac gtctggcgcg agagacgcgg
     2761 ctgctggccg tctgtatcgc cggacccata gatcatcatt tgtcgcctgg tgtcccacca
     2821 tgcgaagcac ggtcaatcta gaccatcggg gcccgtctga agagaggggt gtgtggaatt
     2881 tgtgcgcaag atttgaagcc ggatgcatgg atcggtgacc gcttgcgggt gccttggcga
     2941 cgaaagacgc cctgacctgc ctcgtcacga ccgttcttgt acttgtgcaa acagatccac
     3001 agtcatgtca tgtggctcaa atgctctgcg ggtgggcgcg cagccggcct cgtcttgcca
     3061 acaggactca tcggctccca agggggcgcc cggcgacgac agttaccact gccagtgctt
     3121 gaccggaaaa cctctcccca gacaggggcg cccggcacca ccggcgatgg acctccacgc
     3181 gcagcgatcg ttcgttggtg ttggtggcgc gagccgacca cacggtgacc tcctgatacg
     3241 tcgcacactt ccgtacttcg gaaggactcg cggtgatcta ccgcggtatc gactgggcgg
     3301 aacgcacgca cgatgtcgcc ctggtcgacg acaccggctc gctactggcc aaacgccaca
     3361 tcaccgacga cgcagccggc tacacgctgc tgctggaact cctcgccgag cacgatgact
     3421 tcgggaaaga cccgattccg gtggcaatcg agacctcccg cggcatgctg gcggcggtac
     3481 tgcggaccgg caaacggcag gtcttcgcga tcaacccgat ggccgcggca cgttaccgcg
     3541 accggcactc cgtctcgcgc aggaagcccg accccggtga tgaccttgcg ctggcgaaca
     3601 tcgtgcgcac ggacatgcac gcccaccggc ccctgccgca ggacagtgac ccggcccgag
     3661 ccgtcgccgt cctggcccgc gcccagcagg acgccacctg gaaccgccgg cagatcgcca
     3721 accagctgcg ctccctgctg ggccagtacg acccggccgc actggaagcc ttcgcgccct
     3781 gggccaacgg cctatgccga cccgaagccc gcgagctgtt caagaccgcc ccgacacccg
     3841 cccgggctgc gcggctgacc cgcacccagc tccagtccgc tctcaagcgg gccggccgcc
     3901 ggcgcggcac cgccgccgag gccgatcgcc tccgcgacgt cttccgctcc aactggaagc
     3961 cacctgcacc gccgccgacc agctcaccga cgcggtggaa gtggcgctcc ctcaacaccc
     4021 ggacgccgag gtgctgctga gcttccccgg gctcggcatc cagctcgccg cccggaccct
     4081 cgccgagatc ggggacgacc acacccgcgt cgccgacgcc cgcggcctga aggcatacgc
     4141 cggctcctcg cccatcacca gggcctccgg ccagaagtcg tccatcacga gacggtgggt
     4201 gaagaacgac cggctcaacc acgccggcta cctctgggct ttcgcggccc tgcggccttc
     4261 acccggggcc aacccccact accggcgccg acgggaggtc ggagactggc acgcagctgc
     4321 ccggaggaac cccttcaacc gcgtgatcgg ccagcgggga gtacgaggga cgctggggag
     4381 cccttgagga gacacaccac cagtcctggt tggaccagac caatcctgtc ggaatcgttg
     4441 acatgtacgg cacccgccgc aattctgaga gcgctctcaa cgagaaccgg acggctccac
     4501 tccgccggaa tcgacctcgt tggaatcccc ccacccaagg agagagcgag tgtccagaag
     4561 gctcaaatgg catgccctgg cggtggcggc ggccaccgtc accacggcac ttctcacgtt
     4621 cggcgccccc tccgacgcga acgcggccgt ccccacgacg atcccactca agttcacgaa
     4681 caactccggc cgcagcgaac ccgtgtacat ctacgacctc ggaacactcc tctcgacggg
     4741 ccagcagggc tgggccgacg cgaacggcgc gttccacgcc tggcccgccg gcggcaatcc
     4801 gccgacgccc gcgcccgacg cctcgatcac gggaccggcc aacggccagt cgatgacgat
     4861 ccggatgccc aagttctccg gccggatcta cttctcctac ggccagaaac tcgacttccg
     4921 cctgaccacc ggcggcctgg tgcagccggc cgtgcagaac ccgagcgacc ccaaccacaa
     4981 catcctcttc aactggtccg agtacacgct caacgactcc gggctgtgga tcaacagcac
     5041 ccaggtcgac atgttctcgg ccccgtacgc cgtcggggtc caactcgccg acgggagcac
     5101 caagaacacc ggccacctca aaacgggcgg ctacaccggg ttcttcaacg ccctgcgcgg
     5161 tcagcccggc ggctgggcca atctgatcca gacccggtcc gacggcaccg tcctgcgggc
     5221 gctggctccc ggccacggca tcgaggcggg cgcgctgccg ggcaccgtca tggacgacta
     5281 cgtcaaccgc gtgtggcaga agtacagttc gtcgacgctg acggtgacgc cgttcaccga
     5341 tcagccgaac acgaagtact tcgggcgggt ctccggtgac gtcatgaact tcaccaacag
     5401 cgccggagcg gtcgtcacca gcttccagaa gcccgactcg gacagcatct tcggttgcta
     5461 caagcggctg gacgccccca acgacctggt acgcggcccc atttcacgga ccttgtgcgc
     5521 gggcttcaac cgctcaaccc ttctcaccaa ccccaaccag ccggacacga gctcggcgaa
     5581 cttctaccag gacacggtga ccaaccagta cgcccgcaag atccatgcgc agatggccga
     5641 cggcaaggcc tacgcgttcg ccttcgacga cgtcggcaac tacgagtccc tcgtccacga
     5701 cggcaacccc cagcaggcgt acgtcacgct ggacccgttc aactgacgga caccgagagg
     5761 ctagggcctg tccggcaccg ggcaggtggt ccgcttcacg aggtcgtgcc agccggactc
     5821 caggcgttcg aggggcatcc cgcactgtcg cgtcaggtgg tggatcaggg cgggttccag
     5881 gtagcccatg agggtctggg cgagaagaac gctgtccgcg ccgggcacgg cctcgcgcag
     5941 gagcatgacg acgtgggtga agcggacccg gtacggggcg gagctgaagc ggcgggaggc
     6001 gtccggctcg gcggcgaggt acaggtcgag ccggtcgtgg atctcgcgca ggacccggca
     6061 gccgaaggcg tgcaggcggt ccgccggtgc cgcgccgggg ccgagaggtg gcgggccgct
     6121 gaggaaggcg gcctggaact gctgctcggt gtggtcgagc agggccatca gcaggccggt
     6181 gcggtcaccg aagcggcgga agacggttcc cttgcccacc gaggccgcgg cggcgacggc
     6241 ctccatggtc acattggcga ccccgtgctc ctccaccagg cgggtggcgg cctccagcag
     6301 ccgggcgcgg ttgcgcgcag cgtcggcgcg gagctgcggc gcggcgggcc cgacggtcag
     6361 ctccagcggg accggggccc ccgagggttc ctgccccctc gggaagggcg gaagtggggt
     6421 ggacatgaac acagcgtaac ggcagaaggg gacaactgga ccctggtccg cttaggtgct
     6481 acaacattaa acagaccagc aagcggacct cggtccgctt tattgccgca atgtttcgtc
     6541 cccgggagtt ccccatgtcc gtacgcatcc tcgcgctcgt cggcagcctt cgcgccggct
     6601 cccacaaccg ccagctcgcg gaggcggcca tcaagctcgc ccccgagggc gcggagatcg
     6661 agctgttcga ggggctcgcc gaggtcccct tctacaacga ggacctcgac gtcgagggca
     6721 aggtgccggc cgccgccatc gccctgcgcg aggccgcggg ccgcgccgac gcctttctgc
     6781 tcttctcgcc ggagtacaac ggcacgatca cggccgtcct gaagaacgcc atcgactggc
     6841 tgtcgcgtcc gtacggcgcc agcgccttca ccggcaagcc cgccgccgtg gtcggcaccg
     6901 cgttcggtca gttcggtggc gtctgggcgc aggacgaggc ccgcaaggcc ctggggatcg
     6961 cgggtgccgc cgtcctggag gacctcaagc tctccgttcc cggctccgtg acccgcttcg
     7021 ccgagaccca cccggtcgac gacgccgagg tcgccgccca gctcaccgag gtcgtcgccc
     7081 gcctgcacag ccaggtcggc accgccagcg cctcctgacg actcccccag ggccggtccg
     7141 gtgtcaccgg accggccctt ggcgcgttcc cggcagccgc caaccgcctc caacggcccc
     7201 cggttgtcag cgatcttggc ggaatcggac cctccgggcc aagatgcccg catgaagggt
     7261 gatctctttt ccagtgacca catggtgcag cccgccgtca cgccgggcat gaccatccag
     7321 aacgccaagt cgatcaagta cgccgtcaat ggcgacatgc tcgcgcgcca gggggcgatg
     7381 atcgcctacc gggggaatct gcagttcgag cgcaagggcc agggcgtggg cggcatgctc
     7441 aagcgggcgg tcaccggtga gggactgccg ctgatgacgg tgcgcgggca gggcgaggcc
     7501 tggttcgcgc acgaggcgca gaactgtttc atcatcgaca tcgagccggg cgacctgttc
     7561 accgtgaacg ggcgcaacgt cctgtgcttc gactccacgc tgtcgtacga gataaagacc
     7621 gtgaagggcg cgggcgtcac cggcggcggc atcttcaaca gcgtcttcag cggtcacggc
     7681 agtctggggc tgatctgcga gggcaacccg ctggtgatac ccgtctcgcc gcagcagccg
     7741 gtgtacgtcg acacggacgc ggtcgtcggc tggaccgcgc agctccacac ctcgctgcac
     7801 cgctcgcagt cgatcggttc gatgatccgc ggcggctcgg gcgaggccgt gcagctgaag
     7861 ctggaggggg acggactggt cgtcgtacgg ccgagtgagg cgactccgca gaaggcacag
     7921 cagcactgac gccgggggga gatggcgaaa ggggccccgc ccggtggcgg ggccccttct
     7981 tctggtgccg tcctgctcgt gccgtcctgc tcttaccgtc cgtcagcggc cggcggccgg
     8041 ggtgttggcg gtggtcacat tgacggcggc ccacgccgcg tccaccgcca ggtactcggc
     8101 gctggtcgcc ccgtacatgt cggcagcggc cttgagggtc gcggtccgcg cgtcgtggaa
     8161 gtcggtcgtg gagaccatgt agcgggtcag cgcgcggtag aagatcgcgg tcgccttggc
     8221 gcgtccgatg ccggtcaccc gcgagccgtc gtacgtcggc gagtcgtact tcacaccgcc
     8281 gatcgtcttg cggccactgc cctcggcgag caggtagtac gcgtgcgagg agacgcctga
     8341 gccggcgtgc acctcggtgt cgtacgccgc gggcgaccag tagtcgatgg tgccctccag
     8401 cttgtccagg gaggggtggt cgaggcggcg caggaacttc tgggcgaggc ccagcttctc
     8461 gcccatgagg tagttgggcg ggttcttcgg gttgttggcg gagaactcga cgttggaccc
     8521 gaagatgtcg gcgagcgact cgttgagcgc gcccggctcg ccgtactggt tgccccgcgc
     8581 gtccacccgg gtgggttcga gggcggcggt ggcgtcgacg acgccgtggg tcagctcgtg
     8641 gccggtgacg tccaggacga ccagcggctt cttgaacatg gcgccgtcac cgtcgccgta
     8701 gagcatgcag ccgcacgtcg agtcccagaa ggcgttgccg accttgcggc cgaagtggac
     8761 catcgcgcgg gcgccggtgc tgttgttctt gatgcccttg cggccgaagg tcttcttgta
     8821 gaagtccagc gtctgggtga tgccgtactg ggcgtcgacc gcggtggtgg tccggttggc
     8881 ggtggtgccg gtgccccact tgttggtggt gctggtgaac ttcgtgccgc gcgagaaggc
     8941 ctccagttcc gcgcccttgg cgtcccgggt ctcggtgttc caccgggtgg ggtccttgag
     9001 gaggaagctg gtgcgggcgg tctgcgtggt ggtcagcgtc accttgccgg cgaagaggga
     9061 gatgccgctg ccggtggcct tgaccgggta gcgggcggcc gccgtcgcgc cgaggaggcc
     9121 ggccggctgg gtggccacgc ccgtcaccgg gctcgccgtc tcgcccttct cgcgcagcgt
     9181 cttctccaga tgcggcgaga tgaactcgtc gctgtcgggg gtgttgctgc ggatccggcc
     9241 gctctgcgcg tccacgacga ccgtgcggga gccaccggcc tcggtggtgt cgctgtcggt
     9301 cacgcgcacc tggtaggcga gggcggcggc gccgtcgcgg gcgtcgacga cgagttcggc
     9361 gctgcccgcg tcgccctggg cgaccgcggc ggccttctgt tcggcctgct ggggcgtcag
     9421 cttcgcctcg gtcgtggccg gcttgacggc gtggtcggcg gcccgggtca cgcccaggta
     9481 ggcggactgc ttgccgaggt ggacgacgag gtcgccgccg agcaccggga gcccctggtg
     9541 gctgcggacg aagcggacgt gctgcttgcc gtccgggtcc gtcatgacgt ccgtggcccg
     9601 cagggtgtca cccgggccga caccggtggc cgaggcgtgg gcgaacgcgg cggcccgggc
     9661 ggcctccacc ggcgaggagg ccgaagtcgc ggcgcgggcg ggcgagtcgg gcgccgcgaa
     9721 ggcggggccc atcggaagcg tggccgccgt cgtcaccgcg acggcgatcg ccacgcggcg
     9781 tatgtggggt ctacgcactg agttccttcg aacaggggcg gccggcgtcg ccaaccgccc
     9841 tgaggcacgg cgccgttgaa cgccgtggag gctgtcgggc cctcccgaca gatgcgacga
     9901 gaggggcggt ggttgcccga tgaggtccac caacccgcac atgtgatcga ggtcgcagcg
     9961 cctccggccc acatcgaggg gagccggagg cgcgcaggtg tcagatcgtg cggtgggcga
    10021 gggaggagag gagcgtccgc aggtccgcgg cgggacgtgg ggccagggag gctcccgcca
    10081 gcagggtgtc cgccgcggtg agatgccgac gcgccgcgcc caaggccgcc gtgcgacccc
    10141 ccgcccgctc gaccagggtc gccgcccggc gtacggcgcc gtcgtcgagg acggcggtgg
    10201 aggcgaggag ttcggcgagc ggggagcggc ccggcgcggc cagggcggcg agaacgggga
    10261 gggtcttctt cccgtgccgc agatcaccgt gcaccggctt cccggtgacg gccggatcgc
    10321 cccagatgcc gagcaggtcg tcggcgatct ggaaggccac gccgagatgc cgtccggcgc
    10381 ggtccagggc ggcggccgtc tcctgcggcg ctcccgccag tccggcaccg agggccagcg
    10441 cgcagccgag cagggcaccg gtcttgtgct ccgccatcgc ctcgtactcc cccgcgctca
    10501 ccgcgtcggg gccggtccac gggcggtggg cgaacagcag gtcgtcggcc tgaccgcgga
    10561 ccaggtcgcg cgaggccctc gtcaaccgcc gcacggcggc cgcggcgtgg gaggtcgcgg
    10621 gcgccgcggt gagggtctcg acggccaggg cgaagagcgc gtcgcccgtg aggacggcgg
    10681 ggccggtgcc gtacgccttc cacacggcgg gacggccgcg gcgcagcgcg tcgccgtcca
    10741 tgatgtcgtc gtgcaggagg gagaaggtgt gcagcagttc caccgccacc gcgcccggca
    10801 cgcccgcctc ggcggaacct ccggccgcct cggccccgag cacggcgagt gcctgtcgta
    10861 cgcccttgcc cgggcggtgg gtcgcggggg cgccgccgac ctcgcagcgg ccgagcgcgt
    10921 agccggccat ctccgccacc caggggtgca gcccgtcgat cgcctccgcg agggccgggg
    10981 cgaccagttc gcggcagcgc gccaggatct ccggggcggc gggcggcgcc gtcaggaccg
    11041 tacggggaga ggtcatcggg cggcctccgc gtccgcgccc tccggcgggg tgaggccgag
    11101 ttccgtccgc gcccgttcga ccatctcccg ggcgtgtcgc agcccgatgc cctccaacac
    11161 gcgggccagt tcggtgagtt cggcggcggt ctcggcgtgg tcgcggccga gcctcgccag
    11221 ggacttgacc agcccgagcc gggacagcgc ccggccgcgc ggctcgctca tcgtctcgaa
    11281 ctccgccagt gcctgcgcgt agaggtcccg ggcccgctca taacgcccgg cccggtagag
    11341 gacgttgccg cgcatcttgt ggttgtaggc gagcgccccg gacaggttca tcgcccggca
    11401 ggacacctcc gcctcgctca gcagtgccag cgcgcggtcc gggtcccggt cgcgtacgga
    11461 gatgatgtcc gcgaggccgc gcaaggccca ggcgtggccg cgccggtcct cggcgcgcgc
    11521 ggcgatctcg gccgcttcct cgaacagggc gtacgcggtg tcgtaggcgc cggtgttgcg
    11581 gtgtatctgt gcgatgccct ccagggccca cacggtgtgg cgggcctcgc cgcgcttgcg
    11641 ggcctcggcc agcagttgtt cgtgcagggc ggtcacggcg gcgtagtcgc cctggatgcg
    11701 gccggtctcc gccatgcccg ccagggagta gccgcgtacg acgacgtccc cggactgctt
    11761 gccgagttct gcggccagtc gcagcagccg ccaggccagc gggaacgccc cgcgctggcg
    11821 ggccagggtg ccgccgctcc acagcgccca cgccatcgcg ccggtgtccc gggcctcgcg
    11881 ggcggtgcgg tagctcgcct tccacgcccg gtcggcgtcg gccacctgcc cgagcctgcg
    11941 gtgcgcctcg gcgaccgcca ggcccgaacg ggccgcctcg gcacgggcgc ccacgcgctc
    12001 ggcggcgcgc agctgctcgg tgcccgccgc caggacatcg gtcagcgagg agttcacgga
    12061 cagggtggtc aaagcaccct ggtactcggg ggcgaaggcc ttgccgtaca tggatccctt
    12121 tcgatcggcc gactttcgcg gatcggcggc acccgacgac tcgactctgc gcctcacgta
    12181 tacacacctt gtatacacgg agcgtatagt gtgctggatt tccactcggg aatccctgcc
    12241 ttatcgcggt tgtcgcgccg cccatccgtt gtcgatcaag acggcgacgg cgtgcgccag
    12301 gttgcctgtc gcgaaaaaga agcgcgaacc tccctcgccc caggcatagt tgggccccgt
    12361 gtcagacaga gaaccagaag cgcaaacgat ccccgagggc ccgatgcgcc ccggcgagtt
    12421 cccgatcgac gcctcgctcg tgcgacggct actggccgcg cagttcccac ggtgggccga
    12481 gctgcccctg aagcacttcc cgtcggcggg taccgtcaac gccctgtacc gtctcggcga
    12541 cgacctggcg gtacgcctcc cccggatcga agggggcgcc gaggacgtgg ccaaggaagc
    12601 gcactgggtg ccgcggctcg ccccgctgct cccggccacc ctccccgaga tcctcgccac
    12661 cggcacaccc ggcgagggct acccgtggcc ctggatggtg cagcgctggc tcgacggcga
    12721 acccccgcgc gccgaccgtc tcaccgatcc gctgcccctg gccgccgacc tcggcgcctt
    12781 cgtggccgcg ctgcgccggg tccggctgcc cgacgggccg accgcctacc ggggcgtgcc
    12841 cctgtccacc gccgatgcca tgacccgcgc cgcgctcgac gagctgcgcg gcacgatcga
    12901 cacctccgcc gccaccgccg cctgggaggc ggcgctcgtc gcgcccgcgt ggaccggtcc
    12961 gcccacatgg gtccactccg acctgatgcc cggcaatctg ctcacccgcg ggggccggct
    13021 cgacgccgtg ctggacttcg gcaccgtcgg cgtcggcgac ccggcctgcg acctcatccc
    13081 ggcctggaac ctgctccccg ccgaggcgcg ggacaccttc cggcgggcgg cgggcgccga
    13141 cgacgccacc tgggcgcggg ggcgcggctg ggccctgtcc atggcgctca tccagctccc
    13201 gtactaccgc gtcaccaatc cggtgatcgc cgccaacgcc gagcacgtca tccacgcggt
    13261 cctcacggag gccgacgcca ggccctgaga catcaatgga acgtatattc gaatacggag
    13321 tacgctggag gcatgtccac gcacctccag ggctcgctgt tcgaccagac cgacgagctc
    13381 cacctcagtc agctgaacgc gatgcgccgg acggtcctgg gcgacggggc ctggatcgac
    13441 ctgttgcccg gatggctcag cggcgccgac gccctgttcg cacggctcgt cgacgaggtg
    13501 ccgtggcggg cggaacggcg gcagatgtac gagcacgtgg tggacgtacc gaggctgctc
    13561 gcgtactacc gggcgggcga cgcgctgccg cacccgatcc tcgacgaggc gcgacaggca
    13621 ctgtccgcgc actacgcccg tgagctgggc gaaccgttca ccaccgcagg cctgtgctac
    13681 taccgggacg gccgcgacag cgtggcctgg cacggggacc ggatcgggcg gggcgcacgg
    13741 gaggacacca tggtcgcgat cctctccgtg ggcgctccgc gcgacctgtt gctgcgcccg
    13801 cgccgcggcg gggagaccgt acggcgcccg ctcggacacg gcgacctgat cgtgatgggc
    13861 ggctcctgcc agcgcacctg ggagcacgcc attcccaaga cggcgcgggc ggcggggccg
    13921 cggatcagcg tccagttccg tccggacggc gtgaactgag acgggggcgg ctgttccggt
    13981 ccggcagcgt ccttcgcctc acggcgtcag gagtgcctgg accgtggggc cgtaccggtc
    14041 gacgatgtcc tcgatcgggg tcgcgcgcag ccgggtgccg cgtgcgatgc cgtacatcgc
    14101 gccgagcccg agcagtgtgc cgacggcgag ttcggcgcgc aggtccgcgt cggggccgct
    14161 cagccgcagg gcgaggcggt cgctgacctg ggtgcggaag ttggcgcgca tgatgtcgcc
    14221 ctggtcgccc tggcgcgggg cgaagatgat ccgcaggacg gggtcggctc cgcgctcggt
    14281 ctggcccacg agcacctggc ggaccatgtg ggggcctagt cggtccaggg gtgcggccag
    14341 gagggcggcg gcatccgtct cgaaggacat cacgcgcccg aagagcgcgt ccttgttgcc
    14401 gaagtacttg aggatcagcg gagcgctcac ccccgcgcgg tcggcgatcg ccttgagcgt
    14461 gatgtccgcg tgggcgtgcc gggccatcag atggcgggcc gcgcggagga tggccgcctt
    14521 cgtggcctcg gcgtcgcggc gcggtggggc gatcggggtc gcgctgaggc cggggggcgg
    14581 agtggacacg gtgctcaggc tccttcgaat gcctcgtccc gaggtgcgtc cgaactgccg
    14641 gaggcccgtc gggtgtcacg gagggtgggg tcggcgggta tgacgagggc ggcgacacag
    14701 gccaccagtg cgaccgtacc cgccatggcg aaggccagca gataaccgtg cagcgtgggg
    14761 atcggggcac cgccgacgag gctggtgtgg tggaccagga tggcggcgac ggcggcactg
    14821 ctcacggcct ggccgacggt acgcatcagc acgttgacgc cgttcgcgga cgcggtctgc
    14881 cccgcgggca ccgcgcgcag gatgagggtg ggcagcgccg agtaggagaa cgccgttccc
    14941 atcgcgcaga ccgcggagcc cagcaggatc accagcaggc tgtggctgtt gatgatgcgt
    15001 atgccgtagc cggcggcgat gaccagggtg ccgagggcca gcgtcacccg ggcaccgcgg
    15061 gccgccgaga tacgcgccga gaccggcgag agcagcagca tgatcacccc gccgggcagc
    15121 aggaccaggc ccgtcgccac gatggacagc tcgaggccgt agccggtcgc cttgggtgcc
    15181 tgcaccagct gcgccgtcac cagggagttg gcgtagaagg cgaagccggt cagaagcgcg
    15241 gcgacatggg gcagggcgac gcgggggctg gtcgccagtt tcaggtcgac cagggggcgt
    15301 gcggcgcgta gttgctgcgc ccaccacagg cctaggacgc agacgctccc gacgaacagg
    15361 ccgaggatcc tggggctggt ccagccccac tggccgccct gtgacacccc cagcagcaga
    15421 caggagagcc ccagggccag gcccagcgcg ccggtcatgt cgaagcggcc cggctcgcgg
    15481 acgggggact cgcgcaccgc ccaccaggcc agcgccgtcc cgagggcgcc gaccgcggtc
    15541 gtcccccaga acatgacgtg ccagctcgcg tactgaacca ccatcgcggc gatcggcagg
    15601 ccgagggcgg cgccgatccc gacggtggag ctcatcagcg ccaccgcgga acccgtgcgc
    15661 tcgggcggca gttcgtcccg caggaggctg atcgacaacg gtacgacggc ggccgcggcc
    15721 ccttgcaggg ctcgggccgc gatgagtatg cggatgtcgg acgtgagggc gcacatgagc
    15781 gagccgaccg tcatcatccc gagggcgatc agcagcacct tcttcttgcc gtacatgtcg
    15841 ccggcgcggc ccagcacggg attgagcacc gctccggtca gcagcgtcgc cgtcaccatc
    15901 caggacacag cgcccgctga cgcacccgtc agccgcggca ggtcgggcag cagcggcacc
    15961 accaccacct gcatgacggc catgaggctc ccgccgagcg cgaggaccgg gaccgtcagt
    16021 cggtcacgca gtgccaccat gaactctcca gaagtcggcg cgaagaagag ggtgaatagc
    16081 aattcaccat agctggtgaa ttgctattca cccaatgggc gccctacttc agttgtccgg
    16141 gcgcgcggtc gatccggtag tacagctgcg gcgggatgct agggatcggc ctcaattgat
    16201 cacgtagagc agcaggcagg tgcgaccccc gcggttcgcg ccagcttgcg ggcgtgagcc
    16261 gcgccacccg ccaccggccg acccgggaag atcatcggcg gaacgtccgc cggccggagg
    16321 aattccgcct tccggtcgat cgcggacacc cgcacagcaa gatcatcttc gttcaacctt
    16381 gcacgacatt tacttaattg tcctgatcgc gtccaaccga catccggcga tttctcccgc
    16441 tctccgacga accgataggc atatcgggtc atcgaccgag cttgatcgca ggaggtctcc
    16501 gcatgccgga actcacccgt cgccgtgccc tcggggccgc ggccgccctc gccgccgcgg
    16561 ccggcaccca gaccgtcgcc gtggccaggg ccgcggacac cggacaccac ggcgggcccg
    16621 aggccttcga cgaggtctac cggggtcgtc gcatcacggg ccgcgccgcc gccggcggcg
    16681 gtcaccatca cgaacacggc gccgggtacg ccgtgttcat cgacggggtc gagctgcacg
    16741 tgatgcagaa cgccgacggc agctggataa gcgtcgtcag ccactacgac ccggtgccca
    16801 ccccgcgcgc cgccgcccgc gccgcggtcg tggaactcca gggggcacgg ctcgtccccc
    16861 tcggcatgcc catgccccag cagtgaccca gccccgtcag cacaccgtgg agtcccgcac
    16921 atgaccgtac gcaagaacca ggcgaacctg accgccgacg agaagcggcg tttcaccgac
    16981 gcgctcctcc agctgaagcg cagtggccgg tacgacgcct tcgtcaccac gcacaacgcg
    17041 ttcatcctcg gcgacacgga caacggggaa cggacgggcc accgttcgcc ctccttcctg
    17101 ccctggcacc gcagattcct gctggagttc gagcgggcac tgcagtccgt ggacgcctcc
    17161 gtcgccctcc cgtactggga ctggagcacc gaccgttcgc cccgttccac cctgtgggcc
    17221 cccgacttcc tcggcggcac cgggcgcagc ctggacgggc gggtgatgga cggccccttc
    17281 gcggcctccg cgggcaactg gccgatcagc gtgcgcgtcg acggccgtac gtatctgcgg
    17341 cgttcgctcg gcagcggtgc ccgtgagctg ccgacccgcg cggaggtgga ctccgtgctc
    17401 ggcatggcga cgtacgacat ggcgccctgg aacagttcct cggacggttt ccgcaatcac
    17461 ctcgaagggt ggcgcggcgt caacctccac aaccgggtgc acgtctgggt cggcggccag
    17521 atggccaccg gtgtctcccc caacgacccc gtcttctggc tgcaccacgc ctacatagac
    17581 aagctctggg ccgactggca gcgccgccac cccgcctccg gctatctgcc gctctccggc
    17641 acccccgacg tcgtggacct cgacgagacc atgaagccgt ggaacgacgt gaaaccggcg
    17701 gacctgctgg atcacaccgc gttctacacc ttcgacaccg tctgaccgcg cgttcacagg
    17761 tccggccccg ctcgcccctc ctcctcggga ggggcggcct gggccccacg cccccggccg
    17821 gtgccgaaga tcccacatcc tccccgacgc cccgtcttgg caccagtgtc cgccacgcgc
    17881 ttcgggggct gtccgcccag cgttcggcgg acagcccccg aagcagaccg aggcagggaa
    17941 agtactaggc gttgctgggc tcggccgtac ggcactcggg gtgcccccag ccctggccgt
    18001 tcttggcgat gggctcaccc gccgcgtacg agcggccgca gaggcagcgg cccgggaact
    18061 tggccttgat cgtacgggcc gacgtgccct gccggggcgt cttggcggag gcggcggccg
    18121 tggtgcggcg gcgaccggcg ccggacgggg ccggggtgtc gggggacggc gggggctccg
    18181 gggagccgag gtcgctgcct gcgggctgct gggcgatggc ggcctggctc gcggcgcggt
    18241 cggcgaagtc gttcagccgg tcgccgtcga cctggtgggc ggggacgtaa cggaactcca
    18301 cggtgcggcc gtcgaggagt tcgtcgatgc gcgcgaccag ttcctggttg gcgaccggct
    18361 tcccggaggc cgtcttccag cccttgcgct tccagccggg cagccaggtc gtgacggcct
    18421 tcatcgcgta ctgggagtcc atccggatct ccagcgggac gtccggcgcg atcgccgtca
    18481 acaggcgctc cagcgcggtg agttcggcga cgttgttcgt cgccgtgccc agcgctcccg
    18541 cctcccagcg ggtcggcgtc tccgcgccgt cggccacgac ccacgcccat ccggccggtc
    18601 ccgggtttcc cttcgaagcc ccgtcacagg cggccaccac acgttcaagc atgtccccga
    18661 tcatgccacg gtccggcggc ggctccccgc acgggcagca gtacgctctc ccgcatccgg
    18721 gggctggtgc cgagcagccg cagacccagc agcgtcgccg tgtgcaggac gtacttgccg
    18781 tcacggtggc tggcgaccag tcccccgtcg cgcagcacgc cgatctggta gctggcgctg
    18841 ggcagcgcga tccccacggc ctcggccacc tcggaggtgg tgcgggcact ctgtccggcg
    18901 acctcggtca gtacggcggc cctggtgcgg ccgagcaggc gctcgacccc gccgtccgtc
    18961 ccgtccgcga cggcgagcgg agtcttcgcc accgggtaca cgagcacggg atccagaccg
    19021 gggtccgcca gcgcggtcgg tctgcgccag cagaagtagg agggcaccag gagaagtccg
    19081 cggccctcca gatacaggtc gcgctggacg ggatagtcca cctcgagcac cggggaactc
    19141 cagcgcgcga ccgggcgcag gctctccagc agtgcctggg tgccgccgtc gaggagggct
    19201 cgggcgcgca ccccgacatc gtttcccacc gccgtacgga tgtgcggcca gtgcggttcc
    19261 aggagaccgc ggaagtagat ccccagggag ttcgccagca ccttgagcgc gtcgctgccc
    19321 ggtctgccca gcgaggcggc ccagctcggg accgggcgcg actcggccag ccgcgacagt
    19381 tcgcggacca gttgcacacg cggtgtgcgc agcagttggt cgagtccggc ggaaagaccg
    19441 ccgccggtga ccggtggggt gaggaagtcc ggaatatagc cggtggcggg gatcagggcg
    19501 cgcagtgggc gcagcgcgcg gcccaggttc gagtcgccgg agaatcgttg ccgagccgag
    19561 cgacgccaat gtccgaattc cagcggcccc tggccggttt ccagacggca gacactgcac
    19621 atcagttccc acaggggatc aggctgccgg gccactcgaa tgttctgcag gtcgtccgaa
    19681 gtgaagtgaa tgcggagcat gaggtctctt tcgctcgcaa tccttgtggg gggttcggcc
    19741 gttcgaacgt gccgcaacca caagggggga cgagtaccgc atgcgcatgg ttgcccggga
    19801 ggcaaaaggc ccggtccgcc ccggaggaat tccgccattc tccggggggc cggtccgtgg
    19861 gggatccgtg gtccgttcag gacacgtcgg tcgccttggg catcgcgccc tcggtggtct
    19921 tgacgtcgat cacggagaac gccgcgccct gtgggtcgct cagcgcggcg aagcggccga
    19981 acgggctgct catcggcccg aagcggagaa tcgcgccccg ttcggtggcc ttcgcgaccg
    20041 cggcgtcgca gtcctcgacg gtgaagtaca cgttgaagta cggcgggacc tcgggcggga
    20101 agtcgtccgt catccgcatc cggccgagga ccggatcctc gccgaggtcg tacagcctga
    20161 agtcgacggc gtcgtcgtcc agctgcttca tgcggtaccc gaagacggcc gagaagaagg
    20221 tgtccgactt ctcgggctcg cgggtgaaga cctcggccca gcagtacgcg ccgggcacgc
    20281 cccgggcctc gaagccctcg tgccggccgg gctgccagac gccgaagacg accccgctcg
    20341 ggtcccgggc gatcaccatc gtgccgaagt cgccgacctg catcggctcc atcagcacct
    20401 cgccgccctc ggcccggatc ttctgggcgg tggcggcggc gtcgggtgac gcgaggtaca
    20461 ggcaccaggc ggactggccc tcctggccgg gcatcggcgg gacgacggcg gccaccgcct
    20521 tgccgttcgc gtaggcctgg gtgtagttgc cgtactccga ggacgactcg ccgaacgtcc
    20581 agccgagcac ctcaccgtag aaactcttcg ctccctcgac atcgctgaac atcgcgtccg
    20641 cccagcaggg cgttccctcg ggctgtacgg ccatggcgtt ccactcttcc cggttcgtta
    20701 cggttcattc cggtttcacg ctagccagcc tccgtccggg ccgcgcgccg agcgggacgc
    20761 cctggacgac actggagaga gggctcgagt ggtcgtcgac gggacgggga cacgggatga
    20821 tgcacgcgtg ggaagtggcc aggcccgggc ccatcgaggg ggaaccgctg cgtttcgtcg
    20881 agcggccgat cccggtgccg ggggccgacg agcttctcgt ccatgtgcgc gcgtgcgggg
    20941 tgtgccgcac cgacctgcac gtcagcgagg gagacctgcc ggtgcgccgg ccccgggtga
    21001 cgcccggcca cgaggtcgtc ggcgtggtcg cggcggcggg cgaggacgtg ctcgaccacg
    21061 cggtcggcga ccgggtgggc gtcgcctggc tgcgccgtac ggacggcacg tgcgggtact
    21121 gcgcgcgcgg gtccgagaac ctctgcccgg cctccgagta cacgggctgg gacgccgacg
    21181 gcggctacgc ggagtacacg accgttccgg cggccttcgc ctaccggctg cccggcgagg
    21241 tggacgacgt cgcgctggca ccgctgctgt gcgcgggcat catcggctac cgcgcgctgc
    21301 tgcgggccgc gctgccggac gccggacggc tcggccttta cgggttcggc ggcagcgccc
    21361 atctgtgcgc gcagctggcc ctcgcacagg gcgccaccgt gcacgtactg acgcgtgacc
    21421 cggccgcgcg gcggctcgcg ctggaactcg gggccgcgtc cgcccggggc gcgtacgacg
    21481 agccgcccga gccgctggac agcgcgatcc tgttcgctcc ggtcggcgac ctggtgccgg
    21541 tcgcgttgcg ggccctcgac cggggcggga tcctgtcggt cgccgggatc catctgagcg
    21601 acaccccgcc gctgcgctac gagagcgacc tgttctacga gaaggagctg cgcagcgtca
    21661 cctccaacac ccgccgggac gggcgggact tcctggcgct ggcggcccgc cacggcgtac
    21721 gtgccacgac gcacgtctac ccgctgtccg aggcacagcg ggccctgcgg gacctcaagg
    21781 ccggccgttt cgacggggcg gccgtgctgg tgaacgactt cccggcgcgc acctgagcat
    21841 gcgcgcccgc gacgcgcgtg cgtggatgga accagacgtg cgtgcg
//
