LOCUS       NZ_BMUQ01000009        10216 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces mirabilis strain JCM 4551 sequence09, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUQ01000009
VERSION     NZ_BMUQ01000009.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces mirabilis
  ORGANISM  Streptomyces mirabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 380053)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 117X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650275.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:52:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,311
            Genes (coding)                    :: 9,898
            CDSs (with protein)               :: 9,898
            Genes (RNA)                       :: 81
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 414
            CDSs (without protein)            :: 413
            Pseudo Genes (ambiguous residues) :: 0 of 414
            Pseudo Genes (frameshifted)       :: 172 of 414
            Pseudo Genes (incomplete)         :: 329 of 414
            Pseudo Genes (internal stop)      :: 40 of 414
            Pseudo Genes (multiple problems)  :: 115 of 414
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 239788
            Orig. end                         :: 250004
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUQ01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(561..575)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            complement(1880..4102)
                     /locus_tag="IE289_RS23900"
                     /old_locus_tag="GCM10010317_049230"
     CDS             complement(1880..4102)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="IE289_RS23900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_049230"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_190171096.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.5e-40, bitscore:
                     131.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPDTRSRRRTAPPKRTVPKAKGKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHIPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDTAALAEVKA
                     PAILFWEFNHYVVYDGMGRRFGRRGVHINDPGKGRRFVPMEDFDTSFTGVVLVMEPGPD
                     FHKGGRKPGVLGAMPARLRGTSGTMPAAVLASLLLVAVGAAVPALSRTYIDTYLIGGRT
                     SLLGVLFASMGACVALTVVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTAVGIGVALLNVI
                     AMRVVIRLRATRTAKLRADNARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSALILWIGGLRAVEGHISVGLLVAFQALVTRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFQTDPLYARSGSGESTRRLQGHVELENITFGYSP
                     LDKPLLTGFSLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWEGTIRIDGQRLEDIPR
                     GALAASVSFVDQDVFLFEGTVRDNVALWDPSIPDEAVVAALEDAALYDVVTRRPGGIHS
                     RVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQTVIDNLRKRGCACV
                     VIAHRLSTVRDSDEIVVLQHGTIVERGRHDALVAAGGPYAELVKER"
     gene            complement(4099..4908)
                     /locus_tag="IE289_RS23905"
                     /old_locus_tag="GCM10010317_049240"
     CDS             complement(4099..4908)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="IE289_RS23905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_049240"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_121413969.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLALSVTVVVMAAASVW
                     AVTGTVASTVSAPAVLTHGEGSYILQSPVAGQVTEVVAQEGERLPANAPVLKVRTAQGG
                     TTVVRTVAAGRVTALAATIGAIISTGANVAAVEKVAHADDPLYATVYVPAESAATIPAN
                     AAVDLTVQSVPTQQYGVLRGHVKAVGRSVQTPQQISSFLGDSQLGEQFTKKGRPVAVLV
                     RLDRSAATKSGLKWSSADGPPFALTSMTLATGSIRLADQRPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="IE289_RS23910"
                     /old_locus_tag="GCM10010317_049250"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="IE289_RS23910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_049250"
                     /product="hypothetical protein"
                     /protein_id="WP_067360085.1"
                     /sec_met_domain="strepbact (E-value: 6.4e-38, bitscore:
                     123.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVATAEISDADLDNVSGGLSLNAVGTVSGLVDGVAPVSGL
                     VNTVVGTVEGVTGLNTAPVTGLVAGL"
     misc_feature    5232..5245
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.44"
                     /tool="antismash"
     misc_feature    complement(5769..5782)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.67"
                     /tool="antismash"
     misc_feature    5771..5784
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.47"
                     /tool="antismash"
     gene            5886..7280
                     /locus_tag="IE289_RS23915"
                     /old_locus_tag="GCM10010317_049260"
     CDS             5886..7280
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430713.1"
                     /locus_tag="IE289_RS23915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_049260"
                     /product="S1 family peptidase"
                     /protein_id="WP_190171097.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAIAVGGVAALGAAALLLPHANASQTDAKDAAPKT
                     LKSADASSLASLIASQLGDAFGGAYWDASKQQVIINVVGNNSNVVNTVEKAGAVPRSVN
                     NSLSTLKTAAKTLKSDATIPGTAWSIDPKTNQVQVTADSTVTGAKWAKLTSTVDSLGSG
                     VATVKKSAGTFKTFVSGGDAIFAQTDAGGVRCSLGFNVTASDGAPAFLTAGHCGVAAKQ
                     WSDSQNGQPIATVDQATFPGAGDFSLVKYDDPATQTASEVNEGNGKTVQITQAADATVG
                     QQVLRMGSTTGLHDGSVTGLDATVNFQSETDPNGVDTVTGLIQTDVCAEAGDSGGSLFT
                     ADGSAIGLTSGGSGDCTVGGETFFQPVTAALQATGATLGAGGAAGAGDASAAATDPAAT
                     DPAATDPAATDPAATDPAATDPAATDPAATDPAATDPAAGDQSGTGSDQSSTGMDAGSG
                     LVTSTP"
     gene            complement(7430..9589)
                     /locus_tag="IE289_RS23920"
                     /old_locus_tag="GCM10010317_049270"
     CDS             complement(7430..9589)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="IE289_RS23920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_049270"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_190171098.1"
                     /transl_table=11
                     /translation="MVGVSDWQGSVQAPAGRRTPVGRPLLSLTLASMMEEVHAHSGAVY
                     LLTPGEAVLEMAVMAGMPRSFAAPWERVGLNAPIPVAVAVRERRLVWVGGEEEMARRFP
                     RIAVVLPYPFALAALPVATAGTVYGAVFVTWPGTHPLELSDRERDHLTASCARLALRLE
                     RAAAERRPVNPEPDLLASSAGPAADVLGTVEAARMVARLPYGLCALDLNGRISFANAAT
                     ADMLGVPVSGLLGTQLWASVPWLNDPVYEDRYRAALLSQHVTSFVALRPPGHWLSFRLY
                     PSTTGLSVRISRARSVAEMGRVESRHEDDNTTPRLVTISQVLSLAGALTQAAGVDDVVQ
                     LVADEIAPAVGSKALVVLGSRSGRLHVLGHRGYADAHIVERWHGVPLSAQTPGTQALKT
                     GVPAFFDSRQQLEHLYPDRCATPDGMAAWAYLPLIASGRPVGTCVLGYAEPHTFPADER
                     AVLTSLCGLIAQALERALLYDAKLQLAHGLQAALLPHTLPSLPSIEAAARYLPATQGME
                     IGGDFYDLMPSDGLAAAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQPPEEVMRSTNR
                     LLIDLGAELFASCLYLRLDPAREVAVMSRAGHPPPLLLRPDGRVRVLDLAGGPLLGIDA
                     AATYPTTEVPLVPGSVLALYTDGLIESPGVDIEDALADLGRKLTEGGDLSLNALADRLV
                     EQTGAVTQERLDDVALLLLRVRPHD"
     misc_feature    complement(9878..9893)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 23.96"
                     /tool="antismash"
ORIGIN
        1 cagcggcagg tacaccgagc ccatcaccgt cgtgaggttc ttgatgcggc cgaccttctg
       61 ctggagctca cggctgcgcg cgaactcgcc cgcccaggcg gcgtacgcgt agttctcggc
      121 cgccgcgacc cgcagcttgg gcaggccgcg cagggtctgg aacgcctggt tgttcagctt
      181 gttgctgagc acgaccaggc ggcgctgcca gcgcacctgc cacagaccga gcccgaggaa
      241 cgcggccgcg atgacgacga gcatgccgat cgcggcgagc gccaggggca cgctgtacca
      301 aaggagcagc cccaggttca tcgcgccgac cgtgcccgcc tgcgtgagcg tcgggccgac
      361 gcccgcgagg aggcggcgga tcgcgctgat gcccatggcg gcgctcgcca gctcaccagt
      421 cgagcgggac gtgaagaact tcgtgggcag cctcagcagc cggtcccaca cggcgggttg
      481 gagcgtcgcc tcgatccgcc cctccatccg cagcatcgtg aggttctgga gcagcatgaa
      541 cgcggccgac acgacgctgg tgaccatgat ggccagacag acctgcacga tcaggctgtg
      601 ctgggccttg ggcacgtact cgccaagcac ctggccggtg gcgatcggca ccagcgcgcc
      661 gatcgcgacg gtgacgagac cgctgatcgc gaggttgcgc aggtcgccgc cggtgccctg
      721 gaggcagaag cgcagcagcc gcagcgggct cagcttccgc tcgggcagcg gccggtagaa
      781 catcacggcc cgcgcctcga actccggcgc gttggccttc tcgaccgggg tctcccgccc
      841 cgaagacggc tgtacggcca cgtatccgcc gcgccgccac agcagcgcga ccggggagcc
      901 cgacacggca cggtggccca ccagcgggcc gatgttgtcg cgccaccagc gcccgtcgag
      961 acgtacggca cgggtgcgga cgcgcgaggc gagcgcgatc cgctccaccg ggtcgagccg
     1021 gtcgctctcc gtgccgctgt gcgcggactc ggcgagggtg atcccggacg cgcgggcgac
     1081 cagcttgcag gccgcgtacg tggcgtccgc gtcggccgcc gtcgggcgct tggacgactt
     1141 gccgatcgac gccagcaggg tccggtcggc ctgggcgcgg acggcctcgc ccgccttgat
     1201 gcccgccgcc gtacggtcct cgtggctggc ctccaactgc tcgatccagc ggtcgagcgt
     1261 ggacagcagc cggtactgct ggtcgaccat gccctgccag acaccggagt ccatcagcag
     1321 gtcggccgcc gcctcggcgc cgtacaggga gccgtactgg acactcccgg gcggcacctg
     1381 catccagaag acgtcgtcat cggtcagcgc ggcggcgttc tccgtggcca tcggcgcctg
     1441 gaagagaatg gacaggctgc ggccgacgcc gagggcgagg gcgtactcca gcgggctcga
     1501 tgtcggcggt acgtactggg ggttgccgta gtcgtcgtag gaccaggtct gggtgtccac
     1561 cggctggtac agctcgcgca gcacgatccg gcgcaccaca cagtcccgca acggccgtcc
     1621 cacgagggtg tgttgcgggc cggcgacggg gccgagcagc agggagcccg cttcgaggcg
     1681 gccgaggtgg tgccagtggc cctgttggac ggcgtcgacc gcgaacaggt ccatggcgcc
     1741 cgccgccacc agccagagga cctgcggtcc ttccagatcg aggcggccga ggccggagca
     1801 gtcgaccggc gttcccatgc cgccgagcgc gccgaggacg aggtctccct cgcgtgcgcc
     1861 ctcgtgaacc gtggtcatct catcgctcct tgaccagctc ggcgtacgga ccgccggccg
     1921 ccaccagggc gtcgtgccgc ccgcgttcca cgatcgtgcc gtgctgcagc acgacgatct
     1981 cgtcgctgtc gcgcacggtg ctgagccggt gcgcgatcac cacacaggca cagccgcgct
     2041 tgcgcaggtt gtcgatgacc gtctgctcgg tctcggcgtc cagcgcgctg gtcacctcgt
     2101 cgagcaccag aatgctgggc cgacgcacca acgcccgtgc gatctccagg cgttggcgct
     2161 ggccaccgga gaagttgcgg ccgtcctgct cgacccggct gtggatgcca ccggggcggc
     2221 gcgtgacgac gtcgtacagc gccgcgtcct ccaacgccgc gaccacggcc tcgtcgggga
     2281 tggacggatc ccacagggcc acgttgtcgc ggaccgtccc ctcgaagagg aacacgtcct
     2341 ggtcgacgaa ggagacggag gcggcgagcg cgccgcgcgg gatgtcctcc agccgctgcc
     2401 cgtcgatgcg gatcgtgccc tcccacgggg cgtacaggcc cgatatgagc ctggagaccg
     2461 tggacttgcc gctgcccgag ccgccgacca gggccacctg ctggcccggt ccgaccgtca
     2521 gtgagaagcc ggtgagcagg ggtttgtcga gcgggctgta gccgaacgtg atgttctcca
     2581 gctcgacatg accctggagc cggcgggtgg actcgccgct gccggagcgg gcgtagagcg
     2641 ggtcggtctg gaagttctcg acgtccttga gccgggccac gtcggcggcg aagtcctgga
     2701 tgcggcccgc gacgccgttg agccgggtga ggggcgcggt gaagcgggtg accagggcct
     2761 ggaaggcgac gagcaggccg acggagatgt gcccctcgac cgcccgcaga ccgccgatcc
     2821 acaggatcag cgcggagttg agcgtcgcga gtgtcggtgc gaccacgccc agccaggcgc
     2881 tcggcacccc gaggcgttgc tgttcctcca gcgtggtcgc gtgctgcccg gcccacttac
     2941 ggaagtagcc gtcctccccg ccggtcgcct tcatcgtctc gatcaactgg agcccggtgt
     3001 aggcggtgtt ggtgaggcgc gcgttgtcgg cgcgcagctt cgccgtacgg gtcgcgcgca
     3061 gccggatcac cacgcgcatc gcgatcacgt tgagcagcgc gacgccgatg cccacggccg
     3121 tgagctgcgg gtcgtaggtg tagaggagca ccgcgtacag gacgaccacg atcgcgtcca
     3181 cgcctgccgc cgcgaggtcg cgggccaggg tctcggccac cgcgtcgttc gactggagcc
     3241 gctgcaccag gtcggccggg ctgcgctggg agaagaaggt gacgggcagc cgcagcagat
     3301 ggcgcaggaa gcgggcgctg gagagggtgg aggagatgat ccggccgtgc agcaggttcg
     3361 cctgctggag ccaggtcagc acgacggtca gcgccacaca ggcgcccatc gacgcgaaca
     3421 gcacgcccag cagcgaggtc cggccgccga tgagatacgt gtcgatgtac gtccggctca
     3481 gcgcggggac cgccgcgccg accgcgacca gcagcaggct cgccagcacg gccgcgggca
     3541 tcgtgcccga ggtgccgcgc agccgggccg gcatggcacc caggacgccc ggcttgcggc
     3601 cgcccttgtg gaagtcgggc cccggctcca tgaccagcac cacacccgtg aagctggtgt
     3661 cgaagtcctc catcggcacg aaacggcggc ccttgccggg gtcgttgatg tgcacgccgc
     3721 gccgtccgaa gcggcggccc atgccgtcgt agacgacgta gtggttgaac tcccagaaca
     3781 ggatcgcggg cgccttcacc tcggcgagcg cggccgtgtc catctgcatg cccttggccg
     3841 tgaggccgta actgcgcgcc gccttgagca ggttgctggc gcgcgagccg tcccgggaga
     3901 caccgcaggc gatgcgcagc tcttcgaggg ggatgtggcg gccgtagtgg ccgagcacca
     3961 tggcgaggga ggcggcgccg cactccacgg cctccatctg gaggacggtg ggggtgcgga
     4021 ccgtcttccc cttcgccttg gggaccgtgc gcttgggcgg ggcggtgcgg cgtctgctcc
     4081 gggtgtctgg tgcggtggtc acggcaggag ccaatcgacg gggcgctgat cggccaggcg
     4141 gatcgaaccc gtggccaggg tcatggaggt gagcgcgaac ggcggcccgt cggccgagga
     4201 ccacttcagg ccgctcttcg tcgcggcgga gcggtcgagg cggaccagga cggccaccgg
     4261 cctgcccttc ttggtgaact gttcgccgag ctggctgtca ccgaggaagg aggagatctg
     4321 ctggggggtc tgcacgctcc ggccgaccgc cttcacatgg ccgcgcagta ccccgtactg
     4381 ctgggtcggc accgactgta cggtgaggtc gaccgcggcg ttcgcgggga tggtggcggc
     4441 gctctcggcg gggacgtaca ccgtcgcgta gagcggatcg tcggcgtggg cgaccttctc
     4501 cacggcggcg acgttcgcgc cggtcgagat gatcgcgccg atggtggcgg cgagcgcggt
     4561 gacgcgtccc gcggcgaccg tgcggacgac ggtcgtaccg ccctgggccg tacggacctt
     4621 gagcacgggc gcgttcgcgg gcagccgttc gccctcctgg gcgacgacct cggtgacctg
     4681 ccccgcgacg gggctctgca ggatgtaact gccctcgccg tgggtgagga cggcgggcgc
     4741 gctcacggtg gacgccaccg tgcccgtcac ggcccagacg gacgccgccg ccatgacgac
     4801 caccgtcacg gacagggcga gccagccctg ggggcgggcg aagcgcaccg gaaggtcgag
     4861 ctcttcgggc gactggagct tggcgagggc ctgttggcgg aactgcacgg gacttccctc
     4921 acctgttcga gaggtttacg gcatccgaga agtcccggaa ccggggagtg gttccgggac
     4981 tcaacggcac tgaaacgcga tcagagaccg gcgaccaggc ccgtgaccgg ggcggtgttg
     5041 agaccggtga caccctcgac ggtgccgacg accgtgttga ccaggccgga gaccggggca
     5101 acaccgtcga ccaggccgga gacggtgcca acggcgttca gcgacagacc gccggagacg
     5161 ttgtcgaggt cggcgtccga gatctcggcg gtggcaacct ggggggtgga gttcatgagg
     5221 gaacttccct tcgtatggat attcataagg gggagagcgg cccccctctg gggacagatg
     5281 acggccgcca ccgcgggggt gcggcacccg attccgggcg ctgtgcggcg cccgttcccg
     5341 gatgcctggc tgcgacctcc gcggtgcaac ggatcaaagc acgctcgcgg cgcgcgcatc
     5401 caatcaaccg gggctctcac ctgcgaagtt gagcgtggcc agggcccaac cgtgcaggtg
     5461 tgcgcacgtc tcggcagtca gttcttcaca tgctgtgcgg cattgttccg tcctcgcgct
     5521 tgtcgccccg tgctcgaaag ggacagtccc accgcaatgg cgcggagggg ggcgcgcgag
     5581 tgtgcagatc cgctgtccac cgtgacgcgc ctgcgtattc gatgtgcaga ttccctgaag
     5641 ccgggattcc gttcctgccg gaagacggac cgtcaccaat cggtggcgga acgtgtcgga
     5701 tcagccgctc actcggtgta atggcccgat tgcctggtat ttcgtgtgtt tggccgagcc
     5761 aactcagctc ttttctaaac acagttgaac agcccgcgcg gctcacgcgt atcaacaggc
     5821 atccaggcgc cccctagtca gccgccggac ggtggcctcg accccgtccc caggaggtca
     5881 aagagttgag tcacaaaagg attcccaagc gcaaggccgc cattgctgtc ggaggcgtcg
     5941 cggcgctcgg agcggcggcc ctgctgctgc cccacgccaa cgcctcgcag accgacgcga
     6001 aggacgccgc tcccaagacg ctgaagtccg cggacgcctc gagcctggcc tcgctcatcg
     6061 cctcccagct cggtgacgcc ttcggcggtg cgtactggga cgcctcgaag cagcaggtca
     6121 tcatcaatgt cgtcggcaac aacagcaatg tcgtcaacac cgtcgagaag gccggcgctg
     6181 ttccccgcag cgtcaacaac agcctgtcca cgctcaagac ggctgccaag acactgaagt
     6241 ccgacgcgac catccccggc accgcctggt cgatcgaccc caagacgaac caggtccagg
     6301 tcaccgccga cagcaccgtc acgggtgcga agtgggccaa gctgacgtcg accgtcgact
     6361 cgctcggttc cggtgtggcc acggtcaaga agtccgccgg tacgttcaag acgttcgtgt
     6421 cgggcggtga cgcgatcttc gcccagacgg acgccggcgg cgtccgctgt tccctcggct
     6481 tcaacgtcac agcgagcgac ggcgcccccg ccttcctgac cgccgggcac tgcggtgtcg
     6541 cggccaagca gtggtcggac tcgcagaacg ggcagccgat cgcgaccgtc gaccaggcca
     6601 ccttccccgg tgcaggcgac ttctccctcg tgaagtacga cgaccccgcc acccagacgg
     6661 cgagcgaggt gaacgaaggc aacgggaaga ccgtccagat cacccaggcg gcggatgcca
     6721 cggtcggtca gcaggtcctc cggatgggca gcaccaccgg tctgcacgac ggctcggtca
     6781 ccggtctcga cgccacggtc aacttccaga gtgagaccga ccccaatggc gtcgacaccg
     6841 tcaccggtct catacagacc gacgtctgtg ccgaggcggg cgacagcggc ggctccctgt
     6901 tcaccgcgga cggcagtgcg atcggcctga cttccggcgg cagcggtgac tgcaccgtcg
     6961 gcggcgagac cttcttccag cccgtgaccg ccgccctcca ggcgaccggc gcgacgctcg
     7021 gcgcgggtgg cgccgcgggt gccggcgacg cgagcgccgc ggcgaccgac ccggcggcaa
     7081 ccgaccccgc ggccacggac ccggcggcga ccgaccccgc ggccaccgat ccggcagcca
     7141 cggacccggc ggcgaccgac cccgcggcca cggacccggc ggccaccgac ccggccgcgg
     7201 gcgaccagtc cgggaccggc agcgaccagt ccagcaccgg tatggacgcc ggctccggcc
     7261 tggtgaccag cactccgtga caccggtgac cacgagccac tgacccggtc gtgccaccac
     7321 ggcccggtcg gcagtggaag ggtccggccc tccggcggga gggccggacc ccaccgcgtt
     7381 tcccccgccg ctcacgagag ggccggacgc cgaggggttc cggtaccgct cagtcgtgcg
     7441 gacgcacccg caacagaagc agcgccacgt cgtcgagccg ctcctgcgtc accgccccgg
     7501 tctgctcgac gagacggtcg gccagcgcgt tcagcgacag gtcaccgccc tcggtgagtt
     7561 tccgaccgag gtcggccagg gcgtcctcga tgtccacgcc gggcgactcg atcagaccgt
     7621 cggtgtacag ggcgaggacc gaaccgggga cgagcggcac ctcggtcgtc ggatacgtgg
     7681 cggccgcgtc gatccccagc agtggcccac cggccaggtc gagcacccgg acccgcccgt
     7741 ccggtcgcag cagcagcggg ggcggatgac ccgcgcgaga catgacggcc acctcgcgcg
     7801 ccgggtcgag acgcagatag agacagctcg cgaacagctc ggcccccagg tcgatcagca
     7861 gccggttggt gctgcgcatg acctcctccg gcggctgacc gacggtcgtg taggcccgta
     7921 cggccgtgcg gatctgcccc atcaggcccg ccgccgtcac gttgtgcccc tgcacgtcgc
     7981 cgatgaccgc ggcggccaga ccgtccgagg gcatcaggtc gtagaagtcc ccgccgatct
     8041 ccatcccctg ggtggccggg agatagcgcg cggccgcctc gatcgagggc agcgaaggca
     8101 acgtgtgcgg caacagcgcg gcctgcagac catgcgccag ctgcagcttg gcgtcgtaga
     8161 gcagggcccg ctccagggcc tgcgcgatca gaccgcagag gctggtcagc acggcacgct
     8221 cgtccgccgg gaaggtgtgc ggttccgcgt acccgaggac gcaggtgccc accggacgtc
     8281 cggacgcgat cagcggcaga tacgcccacg ccgccatgcc gtcgggtgtc gcgcaccggt
     8341 ccgggtagag gtgctccagc tgctgacggg agtcgaagaa cgccggcacc ccggtcttca
     8401 gggcctgggt gcccggggtc tgcgcgctca gcggcacccc gtgccagcgc tccacgatgt
     8461 gcgcgtccgc gtacccccgg tggccgagca cgtgcagccg gccggatcgc gagccgagga
     8521 cgaccagggc cttgctgccg acggccggcg cgatctcgtc cgccaccagc tgcaccacat
     8581 cgtcgacgcc cgccgcctgg gtgagcgcgc cggccaggct cagcacctgg gagatggtca
     8641 ccaggcgcgg ggtggtgttg tcatcctcgt gccgcgattc gacgcgcccc atctcggcca
     8701 cagaccgggc ccgggagatg cgcacgctca gtccggtcgt actcggatag agccggaacg
     8761 acagccagtg gccgggcggc cgcagcgcca cgaacgacgt cacgtgctgg ctgaggagcg
     8821 cggcccggta acgatcctcg tagacggggt cgttgagcca gggcaccgac gcccacagct
     8881 gggtgcccag cagcccgctg accgggacgc cgagcatgtc ggccgtcgcg gcgttggcga
     8941 agctgatccg gccgttcaga tccagcgcgc acagcccgta cggcaaccgc gccaccatgc
     9001 gcgccgcctc caccgtgccg agtacgtcgg cggccggtcc cgcggacgac gccagcagat
     9061 ccggctcggg gttgaccgga cgccgctccg ccgccgcccg ctccagacgc agcgcgagcc
     9121 gggcgcagga cgcggtgaga tggtcgcgtt cccggtcgga gagctccagc ggatgcgtgc
     9181 cgggccaggt gacgaagacg gcgccgtaca cggtgcccgc ggtcgccacc gggagggcgg
     9241 ccagcgcgaa ggggtacggc aggaccacgg cgatccgcgg gaagcggcgg gccatctcct
     9301 cctcgccacc gacccagacc aaccgccgct cgcgcaccgc cacggcgacc gggatcggcg
     9361 cgttgagccc cacccgctcc cacggcgccg cgaacgacct gggcatgccc gccatgaccg
     9421 ccatctccag cacggcctca cccggcgtca gcaggtacac cgccccggag tgggcgtgga
     9481 cctcctccat catcgaggcc agcgtcagcg acagcagcgg ccgcccgacc ggcgtccgcc
     9541 gacccgccgg cgcctgtacg gacccctgcc agtcggacac gccgaccacc tcctcgcagg
     9601 gccgcgcgac gggactcagg gatcaaggct ccctcgtgac ggcctttccc gcacggcgaa
     9661 cgccacgcgc ggcacagggt gccgcttgcg ggctctgccg caggcccgac ggccccggaa
     9721 cggtcgcagg ggctgcgcga gcgtcccgga agcgctgtaa ttgcggacgt ggtcagtgag
     9781 ggcgctgcgg aacgcggaaa gaggacgctg cgtgccgaac ttgccctcaa gacgcccacc
     9841 ccggacctgg acccgcgcga gcgacagcgc cgcgtgctcg aacaggcact cgtcttcgcg
     9901 ggcgcgagcg tcgtcgcggt gtactcgccc accgggagcg gcgacgagct gtacctgtcc
     9961 gagtcggcag gcgtccccag gacgctctac ggcctgcgcg acagctatgc cctcaccggc
    10021 ggctccccgg cggtggacgc gtaccgttcg ggccgaccgc tgtggctcgg cccggcggag
    10081 atcgcccgct gcgccgacgc ccgcaggctg ccgtcccagg acttctggct ggccgtcctg
    10141 cccctgccgg acggcggctg cctcgtggcg gccggcgagc gcccgggcgg cttcgacgag
    10201 gaggaccggg agtgcc
//
