LOCUS       NZ_BMUQ01000001        22905 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces mirabilis strain JCM 4551 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMUQ01000001
VERSION     NZ_BMUQ01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces mirabilis
  ORGANISM  Streptomyces mirabilis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 935790)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 117X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650275.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:52:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,311
            Genes (coding)                    :: 9,898
            CDSs (with protein)               :: 9,898
            Genes (RNA)                       :: 81
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 414
            CDSs (without protein)            :: 413
            Pseudo Genes (ambiguous residues) :: 0 of 414
            Pseudo Genes (frameshifted)       :: 172 of 414
            Pseudo Genes (incomplete)         :: 329 of 414
            Pseudo Genes (internal stop)      :: 40 of 414
            Pseudo Genes (multiple problems)  :: 115 of 414
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 238713
            Orig. end                         :: 261618
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMUQ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22905
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22905
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22905
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12905](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12905
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            719..1612
                     /locus_tag="IE289_RS01135"
                     /old_locus_tag="GCM10010317_002450"
     CDS             719..1612
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996483.1"
                     /locus_tag="IE289_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002450"
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_190168083.1"
                     /transl_table=11
                     /translation="MAHDHHDHENAQHAHDHTHMDFAQMIPMLEQEAELFSPLYTEAAG
                     WLRDQRSETGLIVDAGSGPGVISCLLADTFPAARVVAVDEVEPLLERARARADRLGVGD
                     RFSTLRAELGGGLGDLEYPADLLWASRSLHHVGDQRAALAGFARALAPGGTLALMEGGL
                     PMRYFPREIGIGRPGLQSRVDAVHDEWFGRMRDELPGAVRETEDWPVLMTAVGLRHTAT
                     RTFLVDLPAPVSDETRAFVVTSLTHRRDSLAPGLDADDLATLDRLLDPDDKASVYHRPD
                     VFLLTAHTVHVAVKPE"
     gene            complement(1624..3012)
                     /locus_tag="IE289_RS01140"
                     /old_locus_tag="GCM10010317_002460"
     CDS             complement(1624..3012)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092238.1"
                     /locus_tag="IE289_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002460"
                     /product="glycosyltransferase family 39 protein"
                     /protein_id="WP_229888694.1"
                     /transl_table=11
                     /translation="MYAPALLSLALGLWGVRRGGALWRDEAVTYDMARRSLPDLWSTLA
                     DADAVHGLYYLLMHLLFEVTGGLDPLLVLRLPSVLATAAATGTLALLGHRLAGPRAGLL
                     AGSVFALLPQVQRYAQEGRSYAIVCALVVWATYLLVRAVAGRNGRTWVAYAAVLVAAGL
                     LHEFAVLALTAHAVAVPRAARRAWAGAAAVVLATVAPLAVLSTRQSDQVSWIGRPGAGA
                     LAGFAGTAVLALACAAVGRNPTSRVLRGVRLPALALGLLVLPALLLLLVSLVTPLYVDR
                     YVLYGQSGTALLTGTALDRLTRARRTRAAALTCAGAAVLALLPVTLHLRTPQSRVDDVG
                     AIARAVAEAGAPGDGVLYLPARRRAWSLPDPGSLRGLRDLALDRAPAASHTLYGTEVPA
                     PVVRARMITATRIVAVSDPAGQPLDGTPGEIVKRRVLATYFEKCGTRRVQGARVTVYAR
                     PGTC"
     gene            3267..6878
                     /locus_tag="IE289_RS01145"
                     /old_locus_tag="GCM10010317_002470"
     CDS             3267..6878
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.2"
                     /locus_tag="IE289_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002470"
                     /product="NACHT and WD repeat domain-containing protein"
                     /protein_id="WP_190168084.1"
                     /transl_table=11
                     /translation="MGRREKPLDPAQGAVARFALELRGLRDEAGAPTYRAMARRAGYSG
                     PTLSAAAAGEKLPTLPVLLAYVSACGGDTSVWERRWRAALADEADTPAPDDAEGPYPGL
                     ARFEPADRDRFHGRDDLIAELLRLVGRRRVSAVVGASGSGKSSLLRAGLIPALRTSAGT
                     GEAEPAAAVRTRASLPGQHSYPVTEFGTTATEPAPPAVPSPLSATHPPAPAAIRILTPG
                     AHPARTHGALFVPHDAPGDTLLVIDQFEELFALCADPGERALFIERLLTALDPDSRLRV
                     IIGVRADFYGRCAEHGPLAEALRDSTLLVGPMTPQRLREAVVRPAVARRVVVERALTAR
                     IVADVADEPGGLPLMAHALREIWRRRSARTLSLAAYEAIGGVQGAVAHTAEEVYARCTP
                     VEAAAVRALLLRLVNPGDGAEDTRRPVLREELGDADTTARVLEQLVRARLLTVDGDTVD
                     LAHEALISAWPRLRGWVDEDRERLRLHRRLTEAARTWQQLDRDAGALYRGVRLTAAREE
                     FGSGLGELSRLERDFLAASVTAYESGRRAAARAARRLRGLTVSLAVLLCLAVVAGATAW
                     RQSGVSARQRDEAQARRVAAFADTLRPTDPRTAMRLALAAWRTADLPETREAVRTAAAQ
                     SDQAAFTEPAQLGAPDAPHWLGADGRILTTVVRDKAVQWDVRRQRLLREVALPGLSEGI
                     IDVSADARWIAYRGRDGATVRNLTNGESHSVAPGSWTDTGGAFGPSGRTFVVRREGRGA
                     GDERATVEVWDVRRERVLFRHPGGDRDGPLPVLSPNDRYLAWCTHDGERLRVWDVVERR
                     RVATEPPARTQRLLCRSDEPVFTPDNRALAAGTADGVVTWDFHADRGRPLLPMPGEGVN
                     SVEFDPTGAYVLTWGSAGLALWRTDSPAPADGGPRRPLITFPVETPAVTDIRLDPGEGV
                     LRYREGSQAGVVRTLSLHGLISPAWRNKARTDAAFDADGKPAEPAMRPAVRAVAADGTV
                     HTAVSTRDGILVTRQGAHPVSHVVGRRSEGPAAIDPAGRTVVTAEGVLIDVATGGRRQG
                     LQGEDLLPTAVFSPDGRYLAAADTQGRLTLWDAGGQHRIAVLAAADSTVERPTLAFSAD
                     GSLLAASRADGSVRVWETASPRLEGATLPTGDGPVLAIGFTMNARELRIATAHLPLRSA
                     PLTPERAAGEVCARAGGGATRAEWRRYLPDVPYRQTC"
     misc_feature    3324..3326
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3711..3713
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6964..7665
                     /locus_tag="IE289_RS01150"
                     /old_locus_tag="GCM10010317_002480"
     CDS             6964..7665
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-167). E-value: 2.9e-09. Score:
                     29.0. Matches aSDomain:
                     nrpspksdomains_IE289_RS01150_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922768.1"
                     /locus_tag="IE289_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002480"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190168085.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 8.1e-06,
                     bitscore: 20.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSPVALITGGGSGIGAAVARRLLDAGHRVTVTGRGAERLRAFA
                     EELGRPQGLLTVVGNAAEYDQVRAAVELTLKEFGRLDTVVANAGFTTHDTVAEGDPAGW
                     SEMVLTNVLGPALLIRASIDALKETRGRIVLVGSVAGHVHGPGNIYGATKWAVTGLAEN
                     ARREVTEFGVGVTLISPGRVETPFWDSYGSLPPGHLLTADQLAESIVWAIGQPSGVDVN
                     TVVVRPIGQPN"
     aSDomain        6979..7464
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE289_RS01150_PKS_KR.1"
                     /evalue="2.90E-09"
                     /label="IE289_RS01150_PKS_KR.1"
                     /locus_tag="IE289_RS01150"
                     /protein_end="167"
                     /protein_start="5"
                     /score="29.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGGSGIGAAVARRLLDAGHRVTVTGRGAERLRAFAEELGR
                     PQGLLTVVGNAAEYDQVRAAVELTLKEFGRLDTVVANAGFTTHDTVAEGDPAGWSEMVL
                     TNVLGPALLIRASIDALKETRGRIVLVGSVAGHVHGPGNIYGATKWAVTGLAENARRE"
     CDS_motif       6985..7053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE289_RS01150_0001"
                     /evalue="9.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE289_RS01150"
                     /protein_end="30"
                     /protein_start="7"
                     /score="15.2"
                     /tool="antismash"
                     /translation="LITGGGSGIGAAVARRLLDAGHR"
     gene            complement(7721..8416)
                     /locus_tag="IE289_RS01155"
                     /old_locus_tag="GCM10010317_002490"
     CDS             complement(7721..8416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073097.1"
                     /locus_tag="IE289_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002490"
                     /product="glycoside hydrolase family 75 protein"
                     /protein_id="WP_067362125.1"
                     /transl_table=11
                     /translation="MRSRTLTLAAVAGAALLATAALPASASGSVTPRSAQEGSVSAADL
                     LAKVTSCSQISNGKYKTDDETSATIPVCGKNGAVFWKADMDIDCDGQVTGKCNGDADPW
                     FQDDTAFHQSDGKPLRAESLPYVVVPSTSSIWKYTSYGIKGGGVVAVIYNNKVEYAVVG
                     DTGPTKIIGEASYATAKALGIDPDPATGGADSGVTYILFKNSQVSPIESHSAAVSLGDS
                     LAKQFLQNN"
     gene            complement(8672..9463)
                     /locus_tag="IE289_RS01160"
                     /old_locus_tag="GCM10010317_002500"
     CDS             complement(8672..9463)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191514.1"
                     /locus_tag="IE289_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002500"
                     /product="aldo/keto reductase"
                     /protein_id="WP_075029887.1"
                     /transl_table=11
                     /translation="MPQLGFGVWQVPDDEAEQAVATALESGYRSIDTAAIYGNEEGTGK
                     AIATSGIPREELFVTTKLWNSDQGYDSTLRAFDTSLEKLGLDYLDLYLIHWPLPSRGKY
                     IDTYKAFEKLYTDGRIKAIGVSNFYPEYLEQLIEATSVIPAVNQIELHPHLQQHAAREY
                     HAQQGIATEAWSPLGSGKGLLEVPAIVAIAQKHNRTPAQIVLRWHIQLGNVVIPKSVTP
                     SRIKENIDVFDFSLDTEDIAAISALNEDRRLGPDPATFDMG"
     misc_feature    9640..9655
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    9715..9730
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            9788..9982
                     /locus_tag="IE289_RS01165"
                     /old_locus_tag="GCM10010317_002510"
     CDS             9788..9982
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE289_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010317_002510"
                     /product="hypothetical protein"
                     /protein_id="WP_190168086.1"
                     /transl_table=11
                     /translation="MNKSALEGHRAEQVIRETSEERVWETPGYLVVETALEVTAYALGD
                     RLGPVTERATAGAHLARTA"
     gene            10001..>10714
                     /gene="pqqC"
                     /locus_tag="IE289_RS01170"
                     /pseudo=""
     CDS             10001..>10714
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669246.1"
                     /locus_tag="IE289_RS01170"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /pseudo=""
                     /sec_met_domain="TIGR02111 (E-value: 7e-83, bitscore:
                     273.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPVRDDGAAAPWGTAEFTERLRAVAEDRYHDRHPFNVRMHRG
                     ELTPAELRRWIINRFHYQRHIPVKDALILAKFDDPALRRVWVRRIQDHDGTAVGQGGIE
                     RWLRLGEAAGLERPALWDTARVLPGVRLAVEGYVNFCRLRPALDAVAASLTELSAPGLM
                     RTRIAAFERYYPWIEAEGLAYFRTRIGQGGRDSEEALALVQGWARSREQQERAVAALTF
                     KCEVLWALLDAVDRAS"
     misc_feature    10838..10856
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.85"
                     /tool="antismash"
     gene            11569..11823
                     /gene="pqqD"
                     /locus_tag="IE289_RS01175"
                     /old_locus_tag="GCM10010317_002530"
     CDS             11569..11823
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645346.1"
                     /locus_tag="IE289_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002530"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_190168087.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.2e-20, bitscore:
                     67.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.3e-12, bitscore: 41.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRPVLARPVMLRHDPVRDTDLLLMPERVVVLRGHAGSVVRLCD
                     GRREVPEIVAALAERFPGAPVADEVPRFLSALHEEGWLR"
     aSDomain        11578..11817
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE289_RS01175_PqqD_RRE.1"
                     /evalue="1.00E-21"
                     /identifier="RREFam006.1"
                     /label="IE289_RS01175"
                     /locus_tag="IE289_RS01175"
                     /protein_end="83"
                     /protein_start="3"
                     /score="67.4"
                     /tool="antismash"
                     /translation="RPVLARPVMLRHDPVRDTDLLLMPERVVVLRGHAGSVVRLCDGRR
                     EVPEIVAALAERFPGAPVADEVPRFLSALHEEGWL"
     gene            11820..12905
                     /gene="pqqE"
                     /locus_tag="IE289_RS01180"
                     /old_locus_tag="GCM10010317_002540"
     CDS             11820..12905
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="IE289_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002540"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_190168088.1"
                     /sec_met_domain="PF04055 (E-value: 1.6e-24, bitscore: 82.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.9e-07, bitscore: 25.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.8e-06, bitscore: 23.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.3e-10, bitscore:
                     34.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTVDPPWALLAELTHGCPLRCAYCSNPVELISRSRELTAEQWT
                     DVFRQAADLGVVQTHLSGGEPLLRRDLARIVAAADTAGLYTQLVTSGVGLHERRLAELL
                     AAGLRSVQLSVQHADPQAAERIAGARAFTAKERAARLLRATGLPLGLNVVLHRANIDAV
                     DDLITLALAWGADRIELAHTQYYGWAARNRTALLPTRDQVEQARVTVRRRREQLTGSLE
                     LVWVAPDLLDATAKPCMGGWGAVSLTVAPDGTALPCPSAATLPALDAPNVRAHRLDWIW
                     RESKAFNVYRGEAWMPDPCRGCALRTTDFGGCRCQAYALTGDASRTDPACRHAPDHHLV
                     RALVDEAPLRNSAYAYREGGT"
     gene            12902..14101
                     /locus_tag="IE289_RS01185"
                     /old_locus_tag="GCM10010317_002550"
     CDS             12902..14101
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645348.1"
                     /locus_tag="IE289_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002550"
                     /product="glycoside hydrolase family 105 protein"
                     /protein_id="WP_190168089.1"
                     /transl_table=11
                     /translation="MTRRLRAALMAGVLTTAGLTTVAATAPPTPLPRAPVGRPAAAQDW
                     SVALIDSTMARYTPSTIGGWSYPVGLYLYGQYLTYQRTHDARYLTYIKSYVDRFVSSDG
                     SIGQSFNSLDSMQAGRLLTILHHETGQDRYRKAALKIRNRLNTYPRTSDGGFWHADTSS
                     RAHQLWSDGVYMVNPFLVEYGKEFGDATYANDEAAKQLYVYGNHLQVANGLLKHAYDES
                     KTASWADPATGLAPEHWCRAVGWYAMAIVNVLDAIPVNHPRRPQLVGIFRKLAAGLEKY
                     QDPATGRWFQVIDKGARSDNWTETSCSSMFTYALSRGAQQDYLDPHYGTVAQRGYQGVL
                     ARISVGSDGRTNLTDISIGTNVGDYAYYIARDRATNDFHGLGAFLIMNEQLTAHPLRTR
                     "
     misc_feature    12992..12994
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14109..14903
                     /locus_tag="IE289_RS01190"
                     /old_locus_tag="GCM10010317_002560"
     CDS             14109..14903
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482488.1"
                     /locus_tag="IE289_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002560"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_190168090.1"
                     /transl_table=11
                     /translation="MGTTRRTLLGAAFGGAAGAAVGIPATATAAHAASWQLKWSPSASG
                     DKLGAFETIEDDRADSHPAGQPHIFATGDNWRFNMHTVDRDTSTDRQRQEVTGLRNGSG
                     SDYLKWTVGQTWRVTYSMYIPSSLKATTTFTHIMQMKQPGTGTSPIVVQSLRRVNGVQT
                     IELKLAIDDILVGRTDLEPLQNKWIDVDFQIKVGNGSAGTIRWILKSGSTTVIDASKSG
                     VDTFLADRVRPKWGIYRSLGDTSGSLQDCYLLLTNLRGYQLV"
     gene            14915..20416
                     /locus_tag="IE289_RS01195"
                     /old_locus_tag="GCM10010317_002570"
     CDS             14915..20416
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141318.1"
                     /locus_tag="IE289_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002570"
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_229888695.1"
                     /transl_table=11
                     /translation="MKPPMRKRSWAASVFFAFAVVLGLTHPEALAAPRTATAPTSTTAS
                     TSTTAPHAAVFDVHDYGAKGDGSTNDTPAINKAITAANAAGGGTVRFPAGQYKSKSTIH
                     MKSEVTLQVDKGATIQGSSADTYDPPETNPNDAYQDYGHSHFHNAMIYGDRLTHIGFVG
                     EGVIDGLGNLITGNPKSGEADKILSLTRCDGLRLGDGLTLRRGGHFAALINGCTNVTSD
                     HLTIDTASDRDGWNVISTTNVTVTNANIKANDDALVFKSDYALGAKLPNGHVRVSDSYL
                     SAVCCNALMFGSETCGDFSDYQFAKIRIEGSNKSGLGMVSMDGAKISDVHYRDITMTGV
                     HSPIMQKIGTRKRCGNSPGVGSISNVTYDNITATGVSPSFSPTLWGESGHRINGVTFTN
                     VNITVPGGNGTMSTAVPSNDPGDYNPKAIGTRPAYGWYVHNADNVTFTDSSVRYAADDG
                     RPAVIANAANGIRFTRFTAQRGSNSPHDMGFQNVTGYCLTDSHSTSGGALRVSTSGSSE
                     NCGTAAKSTAMATTAVQRSHTGVKPLDLENPRQAFLRGSVGGLFLHWGERTAPAHTSCT
                     AWENDVTNGGWTPDYWVNEAQKLHTQYLVLATFHSRLGYARPWPSKIPGSCSTKRDFLG
                     ELITAAKAKGLKVILYMTDDPQWHNEGGHEWLDSAAYSAYKGTDVDLTTRDGFGRFSYD
                     NFFEVMDRYPDLGGFWIDNDNAYWESHDLYAQIQQKRPNYTLSNNNEDTPIMDMISNEQ
                     KTGMTPSYDYPQAVYTAGPRLTEADFKLPSSGAWWYDGSNPSVDKMLTLGRLITNAGSS
                     VKALMAETAQVNGKFPTNQEAFNNFANSYLGPIWQSLHGTEGGGYMYGGLKPGFWSDGA
                     HGVTTVSKTDPDLHYIHVLTPPSTSTLRIRDNGYRIASVTDLRTGAAVSWSQSGGVLTL
                     TGLANWDPYDTVFKVTTAGRQGIASGVTMSASASASASASGHGAAAAGDGDYLTYWDSN
                     KTLPVNLTFDLGSAKKVQYIGLNQREDSVAYARSDTEQSARIKDYKVFLSNDGSTWGSA
                     VKTGQLASRRGIQGIDLTAANARYVRLEVDTTWAASTDTARYKRLRIDEAWIGTSYATP
                     AATINTYSDNGQALRPAMGWSSWSFVRRWPTEAKIKAQADALVASGLKDHGFVYINLDD
                     FWQKCDANGFVVDSYGRWTVDTAKFPSGIKALADYIHSKGLKFGFYVTPGIAKNAVTRN
                     TPIEGTSYHAADIADTSKTEKNYNCKNMYYIDYGKPGAQEFVNSWAKQFASWGVDYLKI
                     DGVGSADIPDVQAWDKALRATGRPITFALSNNLPIAGASTWKSLANSWRTQGDVECYCG
                     SGDNGSGYPLTDWSHVSARFTSAANWQQYAGPGGWNDLDSLEIGNGDRAGLTADQRRSH
                     FTLWAMAGAPLLLGTDLTNLDSVDKPMLTNDRLIGVDQDGVAAKRIVNSGVKQVWSKKE
                     SDDQYVVALFNTGTSGNSTVGVNWSQVGFTGSGDVTDLWSGSHKGTIADSYSATLRPGE
                     TRLIRVKPVSTVLKTAAASPGMAVAPYEYLGWGSPQNPTSVMSATGVKWFTLAFVLSDG
                     SCNPKWDGSRPLTGGNDQSKINAIRAAGGDVVVSIGGWSGAKLGEKCSSASALAGAYQK
                     VINAYGLKVIDIDIENTEWSNATVRQRVIDALKIVKAGNSGLKTIITFGTTTSGPDSTG
                     VDMIKRGAASGLANDIWCIMPFDFGGGTTNMGTLTTQAMEGLKTRVKSAYGYSDATAYA
                     HIGLSSMNGKTDDSGELVRVADFKTMLAYAQQHHIGRLTYWSVNRDRACGSGSDGDSCS
                     GVSQQPYDYLKVFAQYTG"
     gene            20429..22456
                     /locus_tag="IE289_RS01200"
                     /old_locus_tag="GCM10010317_002580"
     CDS             20429..22456
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020141320.1"
                     /locus_tag="IE289_RS01200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010317_002580"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_190168091.1"
                     /transl_table=11
                     /translation="MKLNRALPWCLSLALAVPLVALTGTAAQAATDYQAEDATISQGAV
                     AANHTGYTGTGFVDYTNITGSYVEFTVSAATAGTSSLALRYANGTSVDRPMDLSVNGTV
                     VASGVSFPATTDWNTWATKSVNVQLDAGSNKIRATATTANGGPNLDRVSVGTAADTQAP
                     SRPGQPSCSAIGEDGLTLSWGASTDNVGVAAYDLYEHGNKLGEAAGDATSKVLTGLSPN
                     TTYNLTVIARDAAGNASQASPVVDCTTRPSSDTTPPGKPGTLTSSNVTATSADLSWGAS
                     TDDKAVVGYDVRSDTTVYKSVTGTSTTLTGLACNSPYTLNVVARDAAGNVSPQSNTVSF
                     TTKACATDGGVPSSIGTVSSGWTIPWGTYWMPDGQTALVTERDDFRVWKVTKDGTRTQV
                     GTVPNAVTTNGEGGLLGVAVDPKWATNHYVYFMHTASEGNRVVRMTYDGSSLTNYTILL
                     QGIKKNRYHNGGRLAFGPDGYLYVSTGEAQTPELAQDKTSLNGKILRMTTDGKAAPGNP
                     FGNYVYSYGHRNPQGLAFDRNGRLWEAEFGNSSKDELNLIKPGANYGWPTCEGSCSVSG
                     MTNPKATWNVSEASPSGIAIVRNVVYMASLRGERLWRIPITGDTENVGTPTAYYVGTYG
                     RLRTVTKVPGADQLWLSTTNCDNNGGAADGSDKIFKVSIS"
     misc_feature    22609..22623
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
ORIGIN
        1 ggtggcgtgg gcgagcgggc ggtgcgcgga ggcctcggcc accttcggac cgagttcgag
       61 gaacgaggcc cccgcctcgc cgtacggctc caggaccggc ggcacgtcga ggtgcgagcc
      121 caccctgata cgggtcgggg cgtcggcctc ggtcacctcg ctgaacagga agagcatcag
      181 cagggcccga ccccgcgagt ggaggttgga gtggtagagc gcctcaccgt cggggaggta
      241 actgccttcg atgtgccagc ccgcgtcgtc cggctcctcc gtgtgcggga accgcagcgg
      301 gaagctgccc agcgcgtagc gcggctccca gcgtctctcg ccgaccagca gatcgaaggc
      361 ctggtgcaga gcgggggagt tggccgcggc ggcgaacggg ccctgcgcca tgctgctcac
      421 ccagtgcacg gggtccttcc aggtgccggg gtcgtccggg tcgtaccccg tctccttcca
      481 cagcagccgg gcgcagctct cggcgacgcg cggcgggaag gcgccctcga tcttcacgaa
      541 cccgtcctcg aggaaccgtt ccaccatctc gtcgtccatg gggccatgct cggggacggg
      601 ccgcttcggg cgcatcaggt tttccgaccg ccgtttttgc tgttcgcgca acatcgttgg
      661 ctgtttccgg gagccgagga gcacgctgtg tacgcacccg gacgagaggc ggaccaccat
      721 ggcacacgac caccacgacc acgagaacgc ccagcacgct catgaccaca cccacatgga
      781 cttcgcccag atgatcccca tgctggagca ggaggcggag ctgttcagcc cgctctacac
      841 cgaggcggcg ggctggctgc gggaccagcg gtccgagacc gggctgatcg tggacgcggg
      901 cagtggcccc ggtgtcatct cctgtctcct cgcggacacc ttccccgcgg cgcgggtcgt
      961 ggccgtggac gaggtggaac ccctgctgga gcgggcccgc gcccgcgccg accggctcgg
     1021 cgtcggcgac cgcttcagca ccttgcgggc cgaactcggc ggcggactgg gtgacttgga
     1081 gtacccggcg gacctgctgt gggcgagcag gtccctgcat cacgtgggcg accagcgcgc
     1141 cgcgctcgcc ggtttcgcgc gcgctctcgc acccggcggc accctcgccc tcatggaggg
     1201 cggcctgccc atgcgttact tcccgcgcga gatcggcatc ggccgtcccg gccttcagtc
     1261 ccgtgtcgac gcggtccacg acgaatggtt cggccggatg cgggacgagc tgcccggagc
     1321 ggtgcgagag acggaggact ggcccgtcct gatgaccgcc gtcggcctgc gccacacggc
     1381 gacccgcacc ttcctcgtcg accttcccgc cccggtctcg gacgagacgc gcgccttcgt
     1441 cgtcacctcg ctcacccacc gccgcgactc cctcgccccc ggcctcgacg cggacgacct
     1501 cgccaccctc gaccgtctcc tcgacccgga cgacaaggcg agcgtgtacc accggccgga
     1561 cgtcttcctg ctgacggcgc acaccgtgca cgtcgcggtg aagccggagt agttcccgtc
     1621 cggtcagcat gtgccggggc gcgcgtacac ggtgacccgg gcaccctgga cccggcgtgt
     1681 gccgcacttc tcgaagtacg tggccaggac ccgccgtttg acgatctccc ccggggtccc
     1741 gtcgagcggc tgccccgcgg gatcgctcac ggcgacgata cgggtcgccg tgatcatgcg
     1801 ggcgcggacg accggcgccg gaacctcggt gccgtacagg gtgtgcgagg cggccggtgc
     1861 gcggtcgagg gccagatcac gcagcccgcg cagggatccg gggtcgggca gggaccacgc
     1921 ccggcgccgc gccggcaggt agaggacccc gtcacccggc gcaccggcct cggcgacggc
     1981 ccgggcgatc gcgcccacgt cgtcgacccg gctctgcggt gtacgcaggt gcagggtgac
     2041 ggggagcagc gcgagaacgg cggcgcccgc gcaggtcagc gccgccgcgc gggtccgccg
     2101 ggcccgggtg agccggtcca gcgccgtgcc ggtcaacagg gcggtgccgc tctggccgta
     2161 gaggacatag cggtccacat acagaggtgt gaccagcgag accagcagga gcagcagggc
     2221 gggcaggacg aggagcccga gcgcgagggc gggcagccgg acgccccgga gtacgcgcga
     2281 agtggggttc cggcctaccg ccgcgcaggc cagggcgagg acggccgttc ccgcgaaccc
     2341 cgcgagcgct ccggcgcccg gtctgccgat ccacgacacc tgatccgact gccgcgtact
     2401 cagcacggcg agcggcgcca ccgttgcgag gaccaccgcc gccgccccgg cccaggcccg
     2461 gcgggcggcg cgtggcacgg cgaccgcgtg cgcggtgagc gccagtacgg cgaactcgtg
     2521 cagcagcccg gcggccacca gcaccgcggc gtaggcgacc caggtgcggc cgttccggcc
     2581 cgccaccgcc cgcaccagca gatacgtcgc ccacacgacc agcgcgcaca cgatcgcgta
     2641 cgaccggccc tcctgcgcgt accgctggac ctgcggcagc agtgcgaaga cggatcccgc
     2701 gaggagaccc gcgcggggtc cggccagccg gtgtccgagg agggccagcg ttcccgtcgc
     2761 cgcggccgtg gcgaggaccg acgggagccg gagcaccagg agcgggtcga gcccgccggt
     2821 gacctcgaac aacaggtgca tgagcaggta gtacagaccg tgtacggcgt cggcgtcggc
     2881 gagtgtcgac cacaggtcgg gcagggaccg ccgcgccatg tcgtaggtca ccgcctcgtc
     2941 ccgccacagg gcgccgccgc gccgaacacc ccacagtccg agggcgagcg agagcagggc
     3001 gggggcgtac accgtcagtg gggtgtgcgg ggcgggcgac gacaacagtg cgggggcgag
     3061 cggcggtctg gaagtgtgtg tggtggcgat ggctgactcc ggcgcgtggt cgatgcctcg
     3121 cggtcccctt cgaggggccc cgaggacgtg caccgtcgag tccagccgcc ggacgattga
     3181 tgggcagccc cgtcgcgggg cacctatcaa tgcaggtggg gagcggtgcc gacggatcgg
     3241 tccgccgcgg acggggggag tcaccggtgg gacgccgaga gaagccgttg gatccggcgc
     3301 agggcgcggt ggcgcggttc gccttagagc tgcgggggct ccgcgacgag gcgggcgccc
     3361 cgacctaccg cgcgatggcc cgccgggcgg gctactcggg gcccaccctg tccgccgcgg
     3421 cggcgggcga gaaactgccc acactgccgg tgctcctggc gtacgtcagc gcgtgcggag
     3481 gggacacctc cgtgtgggag cggcgctggc gtgcggcgct cgcggacgag gcggacacgc
     3541 ccgcaccgga cgacgccgag ggcccgtacc cgggactcgc ccgcttcgag cccgccgacc
     3601 gggaccgctt ccacggccgc gacgacctga tcgccgaact gctgcgactc gtcggccgca
     3661 ggcgggtgtc ggccgtggtc ggcgcctcgg gcagcggcaa gtcgtccctc ttacgggcgg
     3721 ggctgatacc ggcgctgcgc acatcggccg gtacggggga agcggagccg gccgccgcgg
     3781 tgcggacgcg cgcgtcgctc cctgggcaac acagttaccc cgtgaccgaa ttcgggacca
     3841 cggcgaccga gcccgctccg cccgccgtcc cctccccgct gtccgccact cacccgccgg
     3901 cccccgccgc catccgcatc ctcacccccg gcgcccaccc ggcccgcacc cacggcgcgc
     3961 tgttcgtccc gcacgacgcg cccggcgaca ccctgctcgt catcgaccag ttcgaggagc
     4021 tcttcgcgct ctgcgccgac cccggtgaac gggccctgtt catcgagcgg ttgctcacgg
     4081 cgctggaccc ggacagccga ctgcgcgtga tcatcggggt ccgcgccgac ttctacggac
     4141 ggtgcgccga acacggtccg ctcgccgagg cgctgcggga ctccaccctg ctcgtcgggc
     4201 cgatgacccc gcagcggctg cgcgaggcgg tcgtccggcc ggccgtcgcg cgacgggtcg
     4261 tcgtcgaacg cgccctcacc gcacgcatcg tggcggacgt ggccgacgag ccgggcggtc
     4321 tgcccctgat ggcccacgcg ctgcgcgaga tctggcggcg ccgcagcgcc cgtaccctct
     4381 ccctggccgc gtacgaggcg atcggcggcg tccagggcgc cgtcgcgcac accgcggaag
     4441 aggtgtacgc gcgctgcacc cccgtcgagg cggccgcggt acgggcgctg ctgctgcggc
     4501 tggtgaaccc cggtgacggg gccgaggaca cccggcggcc cgtccttcgc gaggaactgg
     4561 gggatgccga caccacggcg cgagtgctcg aacagctggt gagggcacgc ctgttgacgg
     4621 tcgacggcga caccgtcgac ctcgcgcacg aggccctgat cagtgcctgg ccccggctgc
     4681 gcggctgggt ggacgaggac cgcgaacggc tgcggctgca tcgcaggctc accgaggcgg
     4741 cgcgcacctg gcagcagctg gaccgggacg ccggagccct ctaccggggg gtgcgactga
     4801 cggcggcgcg agaggaattc ggctccgggc tgggcgagtt gagccgactg gagcgggact
     4861 tcctggccgc gagcgtgacg gcgtacgagt cgggtcgtcg tgccgccgcc cgcgcggccc
     4921 gccgtctgcg gggtctgacc gtgtccctcg ccgtgctgct ctgtctcgcc gtcgtcgcgg
     4981 gtgcgaccgc ctggcggcag agcggggtca gcgcacggca gcgggacgag gcgcaggccc
     5041 ggcgggtcgc cgccttcgcg gacacgctcc ggccgaccga tccgcgcacg gcgatgcgcc
     5101 tcgcgctcgc ggcctggcgc accgcggacc tgcccgagac ccgcgaggcg gtccggacgg
     5161 ccgccgccca gagcgaccag gccgccttca ccgagcccgc acagctcggc gcccccgacg
     5221 cgccgcactg gctcggcgcg gacggccgga tcctgacaac ggtcgtacgg gacaaggccg
     5281 ttcagtggga cgtacgccgt cagcggctcc tgcgcgaggt cgcgctgccc ggtctttcgg
     5341 aggggatcat cgacgtcagc gccgacgccc gctggatcgc gtaccgcggc cgcgacggcg
     5401 cgacggtcag gaacctgacg aacggggaga gccacagcgt cgcgccggga tcctggaccg
     5461 acaccggcgg ggcgttcggg ccgagcggac gcaccttcgt cgtacggcgc gaggggcggg
     5521 gggccggaga cgagcgggcc acggtcgaag tgtgggacgt acgacgggag cgggtcctct
     5581 tccgacatcc aggaggcgac cgggacggac cgctgccggt tctgagcccg aacgaccgct
     5641 atctcgcctg gtgcacccac gacggggaac gactgcgcgt ctgggacgtc gtcgagcggc
     5701 gccgggtcgc gaccgagccg cccgcgcgga cgcagcggct cctgtgccgc tcggacgagc
     5761 cggtcttcac ccccgacaac cgcgcgctgg ccgcgggaac cgctgacggc gtcgtcacct
     5821 gggacttcca cgccgaccgg ggacgtcccc tgctgccgat gcccggcgag ggcgtcaact
     5881 cggtggagtt cgaccctacc ggcgcctatg tcctcacctg gggttcggcc ggcctcgccc
     5941 tgtggcgtac ggacagcccg gccccggcgg acggcgggcc gcgccgaccg ctcatcacgt
     6001 tccccgtcga gaccccggcc gtcaccgaca tccggctcga cccgggcgag ggcgtgttgc
     6061 gctaccgcga aggttcccag gcgggagtcg tacgcaccct ctcgctgcac gggctcatca
     6121 gcccggcgtg gcggaacaag gcgcggaccg acgccgcgtt cgacgccgac gggaagccgg
     6181 ccgaacccgc catgcggccg gcggtgcgtg ccgtcgccgc ggacggcacg gtgcacaccg
     6241 ccgtcagcac ccgcgacggg atcctcgtca cccgtcaggg cgcgcacccc gtctcccacg
     6301 tcgtcggaag acggagcgaa ggccccgccg cgatcgaccc ggccgggcgt acggtcgtga
     6361 ccgccgaggg agtcctgatc gacgtcgcga cgggcggtcg cagacaggga ctccagggcg
     6421 aggatctcct gccgaccgcg gtcttcagcc cggacggacg ctacttggcc gccgccgaca
     6481 cccaagggcg cctcactctg tgggacgcgg gtgggcagca ccggatcgcc gttctggcag
     6541 ccgccgactc caccgtcgag cggcccaccc tggccttctc ggccgacggc tcgctgctgg
     6601 ccgcgagccg ggccgacggc tcggtccgcg tgtgggagac ggcgtccccg cgactggagg
     6661 gggcgaccct gccgaccgga gacggaccgg tcctcgcgat cggattcacc atgaatgcaa
     6721 gggagttgcg catcgcgaca gctcatctgc ccctgcgctc ggcgccgttg acgccggagc
     6781 gtgcggcggg cgaggtgtgc gcccgggcgg ggggcggggc gacccgggcc gagtggcgca
     6841 gatatctgcc cgacgtgcct taccggcaga cgtgttgagg gaggccggtg gccccggcct
     6901 tgacttcgag ggcgcttcaa gtgatgtact cccgctcgtt gtcgtacaca tacgggggta
     6961 tccatgaccg actcacctgt cgcactcatc accggtggcg gaagcggtat cggcgccgcg
     7021 gtcgcgcggc gactgctcga tgccggccac cgggtcacgg tcaccggccg cggtgcggag
     7081 cggctgcgtg ccttcgccga ggaactcggg cgtccgcagg gcctgttgac ggtcgtcggg
     7141 aacgctgcgg agtacgacca ggtgcgcgcc gcggtcgagc tgacgctcaa ggagttcggg
     7201 cgcctcgaca ccgtcgtggc caacgcgggc ttcaccacgc acgacaccgt cgccgagggt
     7261 gacccggcgg gctggtccga gatggtgctg accaatgtac tgggtcccgc gctgctgatc
     7321 agggcctcca tcgacgccct gaaggagacg cgcggccgga tcgtgctggt cgggagcgtg
     7381 gcgggccacg tccacggccc cggcaacatc tacggggcca ccaagtgggc cgtgaccggg
     7441 ctcgccgaga acgcccgccg cgaggtgacc gagttcggtg tcggcgtgac cctgatctcg
     7501 ccgggccggg tggagacccc gttctgggac agctacggga gtctgccacc cggtcatctg
     7561 ctgacggcgg accagctcgc cgagtcgatc gtctgggcga tcggacagcc ttcgggcgtc
     7621 gatgtgaaca ccgtggtggt acgtccgatc ggccagccca actgacgtcg gacccgcggg
     7681 cgcctcggtt gttgcggcaa cctcggtcgt tgcggaagcc tcagttgttt tgcaggaact
     7741 gcttcgccaa cgagtccccg agcgacaccg ccgcactgtg actctcgatc ggcgacacct
     7801 gggagttctt gaacaggatg taggtcacgc cggagtcggc cccgcccgtg gcagggtcgg
     7861 ggtcgatgcc gagggccttc gccgtggcgt acgacgcctc accgatgatc ttcgtgggcc
     7921 cggtgtcgcc gaccaccgcg tactcgacct tgttgttgta gatcacggcg acgactccgc
     7981 cgcccttgat gccgtagctc gtgtacttcc agatgctgct ggtgctgggc acgacgacat
     8041 acggcagtga ctcggcgcgc agcggcttcc cgtcggactg gtggaacgcc gtgtcgtcct
     8101 ggaaccaggg gtcggcgtcg ccgttgcact tgccggtgac ctgaccgtcg cagtcgatgt
     8161 ccatgtcggc cttccagaac accgcgccgt tcttgccgca cacggggatg gtggccgagg
     8221 tctcgtcgtc ggtcttgtac ttgccgttcg aaatctgcga acaggacgtc accttggcga
     8281 gcaggtcggc cgcgctgacc gaaccctcct gggcggaacg gggggtgacg gagcccgacg
     8341 cgctggccgg gagtgccgcg gtggcgagaa gcgcggcacc ggcgacggcc gcgagggtca
     8401 gtgttcgaga gcgcactgtg ggggaccctt ctgttaggaa agtttcctta ccaggttgcc
     8461 gtacaaggtg gccctcttgc atgaccgcgt caagccctcg ggtggagttg gtccggtcca
     8521 ggggctgaaa ccggcgtggg ggcgtgtcga cgcgtgtcga cgcgtgtggg ggaagtcgat
     8581 gcgtgtgggg gaagacgccg ccggcccgga cacgcggtgc gcgtccgggc cggcgacggg
     8641 gtcggggcag gtcagcccac gggggccggg ctcagcccat gtcgaacgtc gccgggtcgg
     8701 gacccaggcg acggtcctcg ttcagcgcgc tgatcgccgc gatgtcctcg gtgtcgagcg
     8761 agaagtcgaa gacgtcgatg ttctccttga tccgggacgg ggtcacggac ttggggatca
     8821 cgacgttgcc cagctggatg tgccagcgca gcacgatctg ggccggagtg cggttgtgct
     8881 tctgggcgat ggcgacgatc gccgggacct ccagcaggcc cttgcccgag ccgagcgggg
     8941 accaggcctc ggtggcgatg ccctgctgcg cgtggtactc gcgggccgcg tgctgctgga
     9001 ggtgcgggtg cagctcgatc tggttgacgg ccgggatgac ggacgtcgcc tcgatcagct
     9061 gctccaggta ctccgggtag aagttggaga caccgatggc cttgatccgg ccgtccgtgt
     9121 agagcttctc gaaggccttg tacgtgtcga tgtacttgcc ccgggacggc agcggccagt
     9181 ggatcagata caggtcgagg tagtccaggc cgagcttctc cagggaggtg tcgaacgcgc
     9241 ggagcgtcga gtcgtacccc tggtcgctgt tccagagctt ggtggtgacg aagagttcct
     9301 cacgggggat gccagaggtg gcgatggcct tgcccgtgcc ctcctcgttg ccgtagatcg
     9361 ccgcggtgtc gatgctgcgg tatccggact ccagcgccgt ggcgacggcc tgctccgcct
     9421 cgtcgtccgg gacctgccag acaccgaagc ccagctgcgg catctcgacg ccgttgttca
     9481 ggatgatcgg ggggaccttg ctcacgagct ctcgatcctt aagtcgtcgg gtggtactcc
     9541 catggtcaac gatcaccggg cgttatgcat tcctgaccgg cggattcgct gtggattcct
     9601 ggtgagggtc ggagattggc cggaaatgga tccgacctta tcggtccgga ccattgaccg
     9661 agttccgtca tccgaccact ctgtagggcg tcaccgaacg ggttcatgaa cccggtgcac
     9721 gcatgtgaac accagcacct gtctgggctc tacaccccac acccatcagg aaagcaggta
     9781 cgcgcacatg aacaagagcg ccctcgaagg ccaccgcgcg gagcaggtca ttcgggaaac
     9841 atcggaggaa agggtctggg agacccccgg ttatctggtc gtcgagaccg ccctggaggt
     9901 caccgcgtac gccctcggcg atcgactggg cccggtcacc gaacgggcaa ccgccggggc
     9961 acacctggca cgtacggcct agccccacgg ttgtcgaacc atgaccgcga caccggtgcg
    10021 cgacgacggt gccgcggccc cttggggaac cgccgagttc accgagcggc tgcgcgccgt
    10081 cgccgaggac cgctaccacg accgtcatcc cttcaacgtc cgtatgcaca gaggtgagtt
    10141 gaccccggcc gagctgcgcc gctggatcat caaccgcttc cactaccaac gccacatccc
    10201 cgtcaaggac gccctgatcc tggccaagtt cgacgatccc gcactgcggc gggtgtgggt
    10261 ccgcaggatc caggaccacg acggcacggc cgtcgggcag ggcggcatcg aacgctggct
    10321 gcggctgggc gaggccgccg gcctcgaacg gccggcgctg tgggacaccg cccgggtgct
    10381 gcccggtgtc cggctcgcgg tcgagggcta cgtcaatttc tgccgcctgc gccccgcgct
    10441 cgacgcggtc gccgcctccc tcacggagct gtccgcaccg gggctgatgc gcacgcggat
    10501 cgccgcgttc gagcggtact acccctggat cgaggcagag gggctcgcgt atttccgcac
    10561 ccgcatcggg cagggcggcc gtgacagcga ggaggcgctc gccctggtcc agggctgggc
    10621 ccgcagccgt gagcagcagg aacgggccgt ggcggcgctg acgttcaagt gcgaggtgct
    10681 gtgggcgctc ctggacgcgg tggaccgagc gagcgactcc gttccgacgg gcgcgtcgga
    10741 ccgggtgtcg gggggtaccc gtcggggcga cccagccgcc gcaccaccgg gcaccctgcc
    10801 gcgcacaccg ggtcgcggcc atcggggtgg gtcggggagc ggttcggatc accttccggg
    10861 cgcctccggc ggggtggcgg gggatgcgtt gcccgtcgtg gctgagggtg tgccggggga
    10921 tgcctcgggt ctcgcgtccg ggcgtgtgcc gggagatgcc tcgggcctcg tgtctgggtg
    10981 cccgccgggg gatgtcctgc ccttcgtgcc cgagggcgcg ccgggagatg cttcgctctt
    11041 cgtgtccggg ggtgtgccgg gggatgtctc gggcctcggg cctgggcgcg tgtcggggga
    11101 tgccttgttc ttggtgtctg agggtgtgcc cggagatgct tcaccccttg tgtctgagca
    11161 tgtgccgggg gatgtctcgg gcctcgggcc tgagcgcgta tcgggggatg ccttgtcctt
    11221 ggtgtctgag ggtgcgcccg gagatgcctc gcccctcatg tctgattcgg cgtcagggga
    11281 tgtctcacac ctcgtgtctg agttggcgtc aggggatgtc tcgcccggag gcgcctcgcc
    11341 ggggttgtcg gattcggtgg cgacttcgcg tgcgcgcggg cccgcgcagg tgtgtccccg
    11401 cgccgcgcgg gacgtggccg gcggcgacgt ggcttccggg gcttcgggcg cggcggcgca
    11461 ggcacggacc tcgggtgcgt cgatgccgac gaagatcccg ggccgccgcc gcggtgcacc
    11521 cgtgcggacg gacaccccgg tggtgcccgg ccccgcaggg ggcccgtcat gacctggcgt
    11581 cccgttctcg cccgccctgt gatgctccgt catgatcccg tccgtgacac cgacttgctg
    11641 ctcatgcccg aacgcgtcgt cgtcctgcgc ggccacgccg ggagtgtcgt ccggctctgt
    11701 gacggcaggc gcgaggtgcc cgagatcgtc gccgcgctcg ccgaacggtt ccccggcgcg
    11761 ccggtcgccg acgaagtacc ccgattcctc tcggcgttgc acgaggaggg ctggctgcga
    11821 tgacctcgac cgtcgatccc ccctgggccc tgctggccga actcacccac ggctgcccgc
    11881 tgcgctgcgc gtattgctcc aaccccgtcg aactgatcag tcggtcaaga gagctgaccg
    11941 ccgaacaatg gaccgacgtc tttcgtcaag ccgctgacct gggcgtagtc cagacccacc
    12001 tgtccggcgg cgaacccctc ctcagacgcg atctcgcccg gatcgtcgcc gccgccgaca
    12061 ccgcgggcct ctacacccag ctcgtcacca gcggtgtggg cctgcacgag cgaaggctcg
    12121 cggagctgct ggccgcggga ctgcgcagcg tccagctctc cgtacagcac gccgatcccc
    12181 aggccgccga acgcatcgcg ggagctcgcg cgttcactgc caaggagcgc gccgcacggc
    12241 tgctgcgggc gacagggctg ccgctcggtc tgaacgtcgt gctgcaccgg gccaacatcg
    12301 acgccgtcga cgacctgatc acactcgccc tcgcctgggg cgccgaccgg atcgagctcg
    12361 cccacacgca gtactacggc tgggccgccc gcaaccgcac cgccctgctg ccgacccggg
    12421 accaggtcga acaggctcgc gtcaccgtgc gccgccgacg cgaacaactc accggttccc
    12481 tggagttggt ctgggtcgcc cccgaccttc tcgacgccac cgcgaaaccc tgtatgggcg
    12541 gctggggcgc cgtttccctg accgtcgccc cggacggcac cgcgctcccg tgcccctccg
    12601 ccgcgacact cccggcactc gacgcgccga acgtgcgcgc acaccggctc gactggatct
    12661 ggcgcgagtc gaaggccttc aacgtctacc ggggcgaggc ctggatgccg gacccctgcc
    12721 gtggctgcgc cctgcgtacg accgacttcg gcggctgccg ctgccaggcg tacgcgctca
    12781 ccggcgacgc ctcccgcacc gacccggcct gccgccacgc acccgatcac cacctcgtcc
    12841 gcgcgctcgt cgacgaggcc ccgctcagga actccgccta cgcctaccga gagggaggaa
    12901 catgacacga cgactgcggg cagcgctgat ggcgggcgtg ctcaccaccg ccggcctgac
    12961 cacggtggcc gccaccgcac ccccgacacc tttaccccga gcgcccgtgg gaaggcccgc
    13021 cgccgcccag gactggtccg tcgccctgat cgactcgacc atggcccgct acaccccgag
    13081 cacgatcggc ggctggtcgt acccggtcgg gctgtacctc tacggccagt acctcacgta
    13141 ccagcgcacg cacgacgccc gctatctcac ctacatcaag agctatgtcg accgcttcgt
    13201 gtcgagcgac ggttcgatcg gccagagctt caacagtctc gacagcatgc aggcgggccg
    13261 gctgctgacg atccttcacc acgagacggg ccaggaccgc taccgcaagg cggccctgaa
    13321 gatccggaac cgtctgaaca cctacccgcg cacctccgac ggaggcttct ggcacgccga
    13381 caccagcagt cgggcccacc aactctggtc ggacggcgtc tacatggtga acccgttcct
    13441 cgtcgagtac ggcaaggagt tcggggacgc gacctacgcg aacgacgagg ccgccaagca
    13501 gctctacgtc tacggcaacc acctccaggt ggcgaacggc ctgttgaagc acgcctacga
    13561 cgagtcgaag acggcgagct gggccgaccc ggcgaccggc ctcgccccgg agcactggtg
    13621 ccgggcggtc ggctggtacg cgatggcgat cgtcaacgtg ctcgacgcga tcccggtcaa
    13681 ccaccccaga cggccccaac tcgtgggcat cttcaggaag ctggccgccg gcctggagaa
    13741 gtaccaggac ccggccaccg gccgctggtt ccaggtgatc gacaagggcg cccgcagcga
    13801 caactggacc gagacgtcct gctccagcat gttcacctac gccctctcgc gcggcgccca
    13861 gcaggactac ctcgatccgc actacgggac cgtcgcgcaa cgcggttacc agggcgtcct
    13921 cgccaggatc tcggtcggct ccgacggccg caccaacctc accgacatct ccatcggcac
    13981 caatgtcggc gactacgcgt actacatcgc ccgcgaccgg gccacgaacg acttccacgg
    14041 ccttggcgcc tttctgatca tgaacgaaca gctcacagcc cacccactca ggacgaggtg
    14101 agtcagccat gggcaccacc agaaggaccc tgctcggcgc ggcgttcggc ggcgccgccg
    14161 gagccgcggt cggcatcccg gcgacggcca ccgccgccca cgccgcctcc tggcagctga
    14221 agtggtcgcc gtcggcgagc ggcgacaagc tcggcgcctt cgagacgatc gaggacgacc
    14281 gcgccgactc gcaccccgcg gggcagccgc acatcttcgc caccggcgac aactggcgct
    14341 tcaacatgca cacggtcgac cgcgacacct cgacggaccg ccagcgccaa gaagtcacgg
    14401 gcctgcgtaa cggcagcggc agtgactacc tcaagtggac cgtgggccag acctggcggg
    14461 tcacgtactc gatgtacatc ccgagctcgc tgaaggcgac caccaccttc acccacatca
    14521 tgcagatgaa gcagcccggc accggcacct cgcccatcgt cgtgcagtca ctgcggcggg
    14581 tgaacggggt gcagaccatt gagctgaagc tcgcgatcga cgacatcctc gtcggccgca
    14641 ccgacctgga gccgctgcag aacaagtgga tcgacgtcga cttccagatc aaggtcggca
    14701 acggctccgc gggcaccatc cgctggatcc tcaagagcgg ctccaccacc gtcatcgacg
    14761 cgtccaagtc cggcgtcgac accttcctcg ccgaccgggt gcgccccaag tggggcatct
    14821 accggtccct cggcgacacc tccgggtccc tgcaggactg ctacctgctg ctgaccaacc
    14881 tgcgcggcta ccaactggta tgaggagccg ttccatgaaa ccccccatga gaaaacggag
    14941 ttgggcggcg agcgtcttct tcgccttcgc cgtcgtactc ggcctgaccc accccgaggc
    15001 cctcgcggcc ccccgaaccg ccaccgcacc cacgtctacc accgcgtcta cgtccaccac
    15061 cgcaccccac gccgccgtct tcgacgtcca cgactacgga gccaagggcg acggctccac
    15121 caacgacacc cccgctatca acaaggccat caccgccgcc aacgcggcgg gcggcggcac
    15181 cgtccgcttc cccgccggcc agtacaagtc caagagcacc atccacatga agagcgaggt
    15241 cactcttcaa gtcgacaagg gcgcgacgat ccagggctcc agcgcggaca cctacgaccc
    15301 acccgagacc aaccccaacg acgcctacca ggactacggg cacagccact tccacaacgc
    15361 gatgatctac ggcgaccggc tgacacacat cggcttcgtc ggtgagggtg tcatcgacgg
    15421 cctcggcaac ctcatcaccg gcaaccccaa gtccggcgag gccgacaaga tcctctcgct
    15481 gacccgctgc gacggcctgc gcctcggcga cggcctcacc ctgcggcgcg gcggccactt
    15541 cgcggccctc atcaacggct gtacgaacgt cacctcggac catctgacca tcgacaccgc
    15601 gagcgaccgc gacggctgga acgtcatcag cacgaccaac gtcacggtca cgaatgccaa
    15661 catcaaggcc aacgacgacg ccctcgtctt caagagcgac tacgcgctcg gcgccaagct
    15721 ccccaacggc catgtgcggg tgagcgattc atatctgtcg gcggtgtgct gcaacgccct
    15781 gatgttcggg tccgagacct gcggagactt ctccgactac cagttcgcca agatccgcat
    15841 cgagggctcc aacaagtcag ggctcggcat ggtctccatg gacggcgcga agatctccga
    15901 cgtccactac cgcgacatca ccatgaccgg cgtccactcg ccgatcatgc agaagatcgg
    15961 tacccgaaag cgctgcggca acagtcccgg cgtcggctcg atcagcaacg tcacgtacga
    16021 caacatcacg gcgaccgggg tgagtccgtc cttcagcccg acgctgtggg gcgagagcgg
    16081 ccaccggatc aacggggtca ccttcaccaa cgtcaacatc accgtccccg gcggcaacgg
    16141 caccatgtcc accgccgtgc cgagcaacga cccgggcgac tacaacccga aggccatcgg
    16201 cacgcggccc gcctacggct ggtacgtcca caacgccgac aacgtcacct tcaccgacag
    16261 ctcggtgagg tacgcggccg acgacggacg cccggccgtc atcgcgaacg ccgcgaacgg
    16321 gatcaggttc acccggttca cggcccagcg ggggagcaac tcaccccacg acatgggctt
    16381 ccagaacgtc accggctact gcctgacgga cagtcacagc acctcgggcg gcgcgctgag
    16441 ggtttccacc agcggctcca gtgagaactg cggtacggcg gccaagagca cggcgatggc
    16501 gaccacagcc gtgcagcggt cgcacacagg tgtgaaaccg ctcgacctcg aaaacccccg
    16561 ccaggccttc ctgcgcggct ccgtcggcgg actcttcctg cactggggcg aacgcaccgc
    16621 ccccgcccac accagctgca ccgcctggga gaacgacgtc accaacggcg gctggactcc
    16681 ggactactgg gtgaacgagg cccagaaact gcacacccag tacctcgtcc tcgccacctt
    16741 ccacagccgc ctcggctacg cccgcccctg gccctcgaag atccccggca gctgctccac
    16801 caagcgggac ttcctcggcg aactcatcac cgccgccaag gccaagggcc tcaaggtcat
    16861 cctctacatg accgacgacc cccagtggca caacgagggc ggccacgagt ggctcgactc
    16921 ggccgcgtac tccgcctaca agggcaccga tgtcgacctc accacccgtg acggcttcgg
    16981 ccgcttcagc tacgacaact tcttcgaggt catggaccgc tatccggacc tcggcggctt
    17041 ctggatcgac aacgacaacg cgtactggga gagccacgac ctctacgcgc agatccagca
    17101 gaagcgcccg aactacacgc tcagcaacaa caacgaagac acgccgatca tggacatgat
    17161 cagcaatgag cagaagacgg gaatgacccc gtcctacgac tacccccagg ccgtctacac
    17221 ggccgggccc cgcctcaccg aagccgactt caagctgccg tcgagcgggg cgtggtggta
    17281 cgacggctcc aacccctccg tcgacaagat gctcaccctc ggccggctga tcaccaacgc
    17341 gggctcctcc gtgaaggccc tgatggccga gaccgcgcag gtcaacggca agttcccgac
    17401 gaaccaggag gccttcaaca acttcgccaa ctcctatctc ggccccatct ggcagtccct
    17461 gcacggcacc gagggcggcg gctacatgta cggcggcctc aagcccggct tctggagcga
    17521 cggggcccac ggcgtcacca cggtcagcaa gaccgacccc gacctccact acatccacgt
    17581 actgaccccg cccagcacca gcaccctgcg catccgcgac aacggctacc gcatcgcctc
    17641 cgtcaccgac ctccgtacgg gagcggctgt ttcgtggtcc cagtcgggcg gcgtgctcac
    17701 cctgaccggc ctggcgaact gggacccgta cgacaccgtc ttcaaggtca ccacggccgg
    17761 ccgccagggc atcgcgtccg gcgtcacgat gtccgcgagc gcctcggcga gcgcctcggc
    17821 gagcggtcac ggcgcggcgg ccgcgggcga cggcgactac ctcacctact gggacagcaa
    17881 caagacgctg cccgtcaacc tcaccttcga cctcggcagc gcgaagaagg tccagtacat
    17941 cggcctcaac cagcgcgagg actccgtcgc ctacgcgcgc tccgacaccg agcagtccgc
    18001 acgtatcaag gactacaagg tgttcctcag caacgacggg tccacctggg gcagcgcggt
    18061 caagaccggt cagctcgcca gtcggcgggg catccagggg atcgacctga cggccgccaa
    18121 cgcccgatac gtacgcctcg aagtcgacac cacctgggcc gcgtccaccg acaccgcccg
    18181 ctacaagcgg ctgcggatcg acgaggcctg gatcggcacg tcgtacgcca ccccggcggc
    18241 caccatcaac acgtactcgg acaacggcca ggccctccgc cccgccatgg gctggagcag
    18301 ctggagcttc gtgcgccgct ggccgaccga ggcgaagatc aaggcccagg ccgacgcgct
    18361 cgtcgcgagc gggctcaagg accacggctt cgtgtacatc aacctcgacg acttctggca
    18421 gaagtgcgac gcgaacggat tcgtcgtcga ctcctacgga cgctggaccg tcgacaccgc
    18481 caaattcccc tccgggatca aggcgctggc cgactacatc cactccaagg ggctgaagtt
    18541 cggcttctac gtgacgccgg gcatcgccaa gaacgccgtc accaggaaca cgccgatcga
    18601 ggggacctcg taccacgcgg ccgacatcgc ggacacctcg aagaccgaga agaactacaa
    18661 ctgcaagaac atgtactaca tcgactacgg gaagccgggc gcccaggagt tcgtgaactc
    18721 atgggccaag cagttcgcct cctggggagt cgactacctg aagatcgacg gggtgggcag
    18781 cgccgacatc cccgacgtcc aggcctggga caaggcgctg cgcgccaccg gacggcccat
    18841 caccttcgcc ctctccaaca acctgccgat cgcgggcgcc tccacctgga agtcactggc
    18901 gaacagctgg cgcacccagg gcgatgtcga gtgctactgc ggctcgggcg acaacggcag
    18961 cggctatccg ctgaccgact ggtcgcacgt ctccgcccgc ttcacctcgg cggccaactg
    19021 gcagcagtac gcgggcccgg ggggctggaa cgacctggac tcgctggaga tcggcaacgg
    19081 cgaccgggcg ggcctcaccg ccgaccagcg ccgctcgcac ttcaccctgt gggcgatggc
    19141 gggcgcgccc ctgctcctcg gcacggacct gacgaacctc gactccgtcg acaaaccgat
    19201 gctcacgaac gaccggctca tcggtgtcga tcaggacggc gtcgccgcga aacggatcgt
    19261 gaacagcggc gtcaagcagg tctggagcaa gaaggagagc gacgaccagt acgtcgtcgc
    19321 gctcttcaac accggcacgt caggcaactc cacggtcggt gtgaactggt cgcaggtcgg
    19381 cttcaccgga tccggtgacg tcacggacct gtggtcgggc tcccacaagg gcacgatcgc
    19441 cgactcgtac agcgcgaccc tgcgcccggg cgagacgcgc ctgatccgcg tgaagccggt
    19501 gagcaccgtc ctgaagaccg ccgcggcctc acccggcatg gcggtggcgc cctacgagta
    19561 cctcggctgg ggcagcccgc agaacccgac ctcggtcatg tcggccaccg gggtgaagtg
    19621 gttcacgctc gcgttcgtcc tctccgacgg ctcctgcaac ccgaagtggg acggctcgcg
    19681 cccgctgacc ggcggcaacg accagtcgaa gatcaacgcg atccgcgcgg ccggcggtga
    19741 cgtcgtcgtc tccatcggcg gctggagcgg cgccaagctc ggcgagaagt gctccagcgc
    19801 ctcggcgctc gcgggcgcct accagaaggt catcaacgcc tacggcctca aggtcatcga
    19861 catcgacatc gagaacaccg agtggagcaa cgccaccgtc cggcaacggg tgatcgacgc
    19921 gctgaagatc gtgaaggccg gcaactccgg gctcaagacg atcatcacct tcggcacgac
    19981 gaccagcggt ccggactcca ccggcgtcga catgatcaag cgcggcgccg cctcgggcct
    20041 cgcgaacgac atctggtgca tcatgccgtt cgacttcggc ggcggcacca cgaacatggg
    20101 cacgctcacc acccaggcca tggagggact caagacccgg gtcaagtcgg cttatggata
    20161 cagcgacgcg acggcgtacg cgcacatcgg cctgtcgtcc atgaacggca agaccgacga
    20221 ctccggcgaa ctggtccgtg tcgccgactt caagaccatg ctcgcctacg cccagcagca
    20281 ccacatcggg cgcctcacct actggtccgt gaaccgcgac cgggcctgcg gctccggctc
    20341 cgacggtgac tcctgcagcg gcgtgtcgca gcagccgtac gactacctca aggtcttcgc
    20401 ccagtacacg ggctgagggg acgaacccat gaaactcaac agagcgctgc cctggtgcct
    20461 ctcgctcgcc ctggccgtgc cgctcgtcgc actgaccggc acggcggcgc aggcggccac
    20521 cgactaccag gccgaggacg ccacgatctc gcagggcgcc gtcgccgcca accacaccgg
    20581 ttacacggga accggcttcg tcgactacac caacatcacc ggctcgtacg tggagttcac
    20641 ggtgagcgcg gccacggccg gcacctcctc gctggccctg cgctacgcca acggcacgag
    20701 cgtcgaccgc ccgatggacc tctccgtcaa cggcacggtc gtcgcctccg gggtctcctt
    20761 cccggccacc accgactgga acacctgggc gacgaagagt gtgaacgtcc agctcgacgc
    20821 gggttccaac aagatccgcg cgaccgccac cacggcgaac ggcggcccca acctcgaccg
    20881 cgtcagcgtc ggtaccgccg ccgacaccca ggcaccctcg cggccgggcc agccgagctg
    20941 ttcggccatc ggcgaggacg gcctcaccct ctcctggggc gcctccacgg acaacgtcgg
    21001 cgtggccgcg tacgacctct acgagcacgg caacaagctc ggcgaggcag ccggtgacgc
    21061 gacctccaag gtgctcaccg gcctgagtcc gaacaccacc tacaacctca ccgtcatcgc
    21121 ccgcgacgcc gccggcaacg cctcccaggc cagcccagtc gtcgactgca cgacacggcc
    21181 cagctccgac accaccccgc ccggcaaacc cggcaccctc acctcctcga acgtcacggc
    21241 caccagcgcc gacctgagct ggggcgcctc gaccgacgac aaggcggtcg tcggctacga
    21301 cgtgcgcagc gacacgacgg tctacaagag cgtcaccggt acgtcgacca cgctcaccgg
    21361 gctcgcctgc aacagcccgt acacgctgaa cgtggtggcg cgcgacgcgg ccggcaacgt
    21421 gtcgccgcag agcaacacgg tcagcttcac gaccaaggcc tgtgccaccg acggcggggt
    21481 cccctcgtcc atcgggaccg tctccagcgg ctggacgatc ccctggggca cgtactggat
    21541 gcccgacgga cagacggcgc tggtcaccga gcgggacgac ttccgggtct ggaaggtcac
    21601 caaggacggc acgaggaccc aggtcggaac cgtgccgaac gccgtgacca cgaacggcga
    21661 gggcggactg ctcggcgtgg ccgtcgaccc gaagtgggcc accaaccact acgtgtactt
    21721 catgcacacg gcctccgagg gcaaccgcgt cgtccgcatg acctacgacg gcagctccct
    21781 caccaactac acgatcctcc tccagggcat caagaagaac cgttaccaca acggcggacg
    21841 cctcgccttc ggccccgacg gctatctgta cgtctccacc ggcgaggccc agacacccga
    21901 actggcccag gacaagacgt cgttgaacgg caagatcctg cggatgacga cggacggcaa
    21961 ggccgccccc ggcaacccgt tcggcaacta cgtctacagc tacgggcacc gcaacccgca
    22021 gggcctcgcc ttcgaccgca acggccgcct gtgggaagcg gagttcggca acagctccaa
    22081 ggacgaactc aacctcatca aaccgggcgc caactacggc tggccgacct gcgagggcag
    22141 ttgcagcgtc tccgggatga ccaacccgaa ggcgacctgg aacgtctccg aggcgtcacc
    22201 cagcggcatc gcgatcgtcc gcaacgtcgt ctacatggcg tccctgcgcg gcgaacggct
    22261 gtggcgcatc cccatcaccg gcgacacgga gaacgtcggc acgccgacgg cgtactacgt
    22321 cggcacctac ggccgcctgc gcacggtcac caaggtgccc ggcgccgacc agctctggct
    22381 ctccaccacc aactgcgaca acaacggagg agcggcggac ggctcggaca agatcttcaa
    22441 ggtgagcatc agctagccgg accgaggcgt tgcggcgggc tcatgcccgg tacaacgcct
    22501 ccacctccgt cgcgtacgcg ttctcgatcg ccttccgctt caacttcagc gacggcgtca
    22561 gcaacccgtg ctcctcggtg aactggttcg ccagtatccg gaacgtacgg atcgactcgg
    22621 cctgcgagac cagggtgttc gcggcgacca ccgcccgccg cacctcggtc tccaggtccg
    22681 ggtcgcgcac caggtcggac ggggacagcc gcgtcttgcc ccgcatctgg agccagtgtt
    22741 cgacggcctc ggagtcgagg gtgacgagcg ccgcaatgta cggccggtcg ttgccgacca
    22801 cgatgcactg ggcgaccagc gggtggtcac gcacgcgctc ctccaggacg cccggcgaga
    22861 cgctcttgcc gccggaggtc accaggatct ccttcttgcg cccgg
//
